Accelerated Closure of Diabetic Wounds by Efficient Recruitment of Fibroblasts upon Inhibiting a 14-3-3/ROCK Regulatory Axis

Chronic non-healing wounds negatively impact on quality of life and are a significant financial drain on health systems. The risk of infection that exacerbates co-morbidities in patients necessitates regular application of wound care. Understanding mechanisms underlying impaired wound healing are therefore a key priority to inform effective new generation treatments. Here, we demonstrate that 14-3-3-mediated suppression of signaling through ROCK is a critical mechanism that inhibits the healing of diabetic wounds.

Source: Journal of Investigative Dermatology - April 4, 2024 Category: Dermatology Authors: M. Zahied Johan, Natasha T. Pyne, Natasha Kolesnikoff, Valentina Poltavets, Zahra Esmaeili, Joanna M. Woodcock, Angel F. Lopez, Allison J. Cowin, Stuart M. Pitson, Michael S. Samuel Tags: Original Article Source Type: research