Neutrophil-driven M2-like macrophages are critical for skin fibrosis in a systemic sclerosis model

In this study, we elucidated that CD206hiMHCIIlo M2-like macrophages constitute the predominant pathogenic immune cell population in the fibrotic skin of a bleomycin (BLM)-induced SSc mouse model. These cells emerged as pivotal contributors to the profibrotic response by orchestrating the production of TGF- β1 through a MerTK signaling-dependent manner.

Source: Journal of Investigative Dermatology - April 3, 2024 Category: Dermatology Authors: Pixia Gong, Yayun Ding, Wen Li, Jie Yang, Xiao Su, Ruifeng Tian, Yipeng Zhou, Tingting Wang, Junjie Jiang, Rui Liu, Jiankai Fang, Chao Feng, Changshun Shao, Yufang Shi, Peishan Li Tags: Original Article Source Type: research