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IL-26 Potentiates Type 2 Skin Inflammation in the Presence of IL-1 β
This study aimed to investigate the downstream effects of IL-26 on skin in the context of type 2 skin inflammation. We found that IL-26 alone exhibited limited inflammatory activity in the skin. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - January 16, 2024 Category: Dermatology Authors: Katharina Bier, Zuzana Senajova, Fanny Henrion, Yichen Wang, Sandro Bruno, Celine Rauld, Lisa C. H örmann, Carmen Barske, Corinne Delucis-Bronn, Sebastian Bergling, Marc Altorfer, Jasmin Hägele, Judith Knehr, Tobias Junt, Ben Roediger, Till A. Röhn, Fr Tags: Original Article Source Type: research

A Narrative Review: Opportunities and Challenges in Artificial Intelligence Skin Image Analyses Using Total Body Photography
Artificial intelligence (AI) algorithms for skin lesion classification have reported accuracy at par with and even outperformance of expert dermatologists in experimental settings. However, the majority of algorithms do not represent real-world clinical approach where skin phenotype and clinical background information are considered. We review the current state of AI for skin lesion classification and present opportunities and challenges when applied to total body photography (TBP). AI in TBP analysis presents opportunities for intrapatient assessment of skin phenotype and holistic risk assessment by incorporating patient-...
Source: Journal of Investigative Dermatology - January 16, 2024 Category: Dermatology Authors: Clare A. Primiero, Gisele Gargantini Rezze, Liam J. Caffery, Cristina Carrera, Sebastian Podlipnik, Natalia Espinosa, Susana Puig, Monika Janda, H. Peter Soyer, Josep Malvehy Tags: Review Source Type: research

AP-2 α/AP-2β transcription factors are key regulators of epidermal homeostasis
AP-2 transcription factors regulate ectodermal development but their roles for epidermal homeostasis in the adult skin are unknown. We find that AP-2 α is the predominant AP-2 family member in adult epidermis, followed by AP-2β. Through inactivation of AP-2α, AP-2β, or both in keratinocytes we assessed the effects of a gradient of epidermal AP-2 activity on skin function. We find that (1) loss of AP-2β in keratinocytes is compensated for by AP-2α, (2) loss of AP-2α impairs terminal keratinocyte differentiation and hair morphogenesis, and (3) the combined loss of AP-2α/AP-2β results in more severe skin and hair abn...
Source: Journal of Investigative Dermatology - January 16, 2024 Category: Dermatology Authors: Hui Zhang, Jackelyn R. Raymundo, Kathleen E. Daly, Wenjuan Zhu, Bill Senapati, Hanyu Zhong, Arjun R. Ahilan, Alexander G. Marneros Tags: Original Article Source Type: research

Gamma-secretase inhibitors down-regulate the pro-fibrotic Notch signaling pathway in recessive dystrophic epidermolysis bullosa
Recessive dystrophic epidermolysis bullosa (RDEB) is a rare skin fragility disorder caused by mutations in COL7A1. RDEB is hallmarked by trauma-induced unremitting blistering, chronic wounds with inflammation and progressive fibrosis, leading to severe disease complications. There is currently no cure for RDEB-associated fibrosis. Our previous studies and increasing evidence highlighted the pro-fibrotic role of Notch pathway in different skin disorders, including RDEB. Here, we further investigated the role of Notch signaling in RDEB pathogenesis and explored the effects of its inhibition by γ-secretase inhibitors DAPT an...
Source: Journal of Investigative Dermatology - January 16, 2024 Category: Dermatology Authors: Angelo Giuseppe Condorelli, Rebecca Nobili, Anita Muglia, Giorgia Scarpelli, Elisa Marzuolo, Cristiano De Stefanis, Rossella Rota, Andrea Diociaiuti, Rita Alaggio, Daniele Castiglia, Teresa Odorisio, May El Hachem, Giovanna Zambruno Tags: Original Article Source Type: research

Tnf signaling deficiency promotes UVB-induced melanocyte stem cell activation and migration
In recent decades, the incidence rate of melanoma has risen rapidly in the United States ( “Melanoma Skin Cancer Statistics” 2023), with ultraviolet B (UVB) exposure representing a significant risk factor (Armstrong and Kricker 2001). Understanding the cellular and molecular mechanisms of UVB-induced melanocyte stem cell (McSC) activation could uncover novel methods to prevent melanom a initiation. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - January 16, 2024 Category: Dermatology Authors: Luye An, Dahihm Kim, William Zhuang, Andrew C. White Tags: Letters to the Editor Source Type: research

Plantar skin exhibits altered physiology, constitutive activation of wound-associated phenotypes, and inherently delayed healing
Wound research has typically been performed without regard for where the wounds are located on the body, despite well-known heterogeneities in physical and biological properties between different skin areas. Skin covering the palms and soles is highly specialized, and plantar ulcers are one of the most challenging and costly wound types to manage. Using primarily the porcine model, we show that plantar skin is molecularly and functionally more distinct from non-plantar skin than previously recognized, with unique gene and protein expression profiles, broad alterations in cellular functions, constitutive activation of many ...
Source: Journal of Investigative Dermatology - January 16, 2024 Category: Dermatology Authors: Christiane Fuchs, Katherine J. Stalnaker, Clifton L. Dalgard, Gauthaman Sukumar, Daniel Hupalo, Jonathan M. Dreyfuss, Hui Pan, Ying Wang, Linh Pham, Xunwei Wu, Ivan Jozic, R. Rox Anderson, Sunghun Cho, Jon H. Meyerle, Joshua Tam Tags: Original Article Source Type: research

Interleukin-26 potentiates type 2 skin inflammation in presence of interleukin-1 β
This study aimed to investigate the downstream effects of IL-26 on skin in the context of type 2 skin inflammation. We found that IL-26 alone exhibited limited inflammatory activity in skin. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - January 16, 2024 Category: Dermatology Authors: Katharina Bier, Zuzana Senajova, Fanny Henrion, Yichen Wang, Sandro Bruno, Celine Rauld, Lisa C. H örmann, Carmen Barske, Corinne Delucis-Bronn, Sebastian Bergling, Marc Altorfer, Jasmin Hägele, Judith Knehr, Tobias Junt, Ben Roediger, Till A. Röhn, Fr Tags: Original Article Source Type: research

Computational Flow Cytometry Accurately Identifies Sezary Cells Based on Simplified Aberrancy and Clonality Features
Flow cytometric identification of circulating neoplastic cells (Sezary cells) in patients with mycosis fungoides (MF) and Sezary syndrome (SS) is essential for diagnosis, staging and prognosis. While recent advances have improved the performance of this laboratory assay, the complex immunophenotype of Sezary cells and overlap with reactive T cells demand a high level of analytic expertise. We utilized machine learning to simplify this analysis using only 2 pre-defined Sezary cell-gating plots. We studied 114 samples from 59 patients with SS/MF, and 66 samples from unique patients with inflammatory dermatoses. (Source: Jour...
Source: Journal of Investigative Dermatology - January 16, 2024 Category: Dermatology Authors: Jansen N. Seheult, Matthew J. Weybright, Dragan Jevremovic, Min Shi, Horatiu Olteanu, Pedro Horna Tags: Original Article Source Type: research

Clinical Snippets
Monogenic etiologies are increasingly found to contribute to the population disease burden, and understanding the affected pathways can affect treatment decisions, improving healthcare efficiency. Inborn errors of immunity (IEIs) are monogenic etiologies that cause immune dysregulation and are associated with infection, autoimmunity, allergy, pathological inflammation, and cancer. Colvin et  al utilized bioinformatic analyses to identify 316 IEI genes that are associated with cutaneous manifestations. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - January 12, 2024 Category: Dermatology Tags: Clinical Snippets Source Type: research

Editorial Board
(Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - January 12, 2024 Category: Dermatology Source Type: research

Subscription Information
(Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - January 12, 2024 Category: Dermatology Source Type: research

Table of Contents
(Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - January 12, 2024 Category: Dermatology Source Type: research

Editors ’ Picks
Soft microfluidic analysis systems that adhere to the skin have been developed to capture, store, and evaluate biomarkers in eccrine sweat, which comprises the largest total volume of sweat loss. In a recent perspective, Yang et  al (2023) described the development and benefits of these systems. Activation of eccrine sweat glands through increased temperature, exercise, or pharmacological agents induces sweat production, and wearable microfluidic patches collect and analyze sweat samples in real time in a simple, cost-effe ctive, and noninvasive manner. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - January 12, 2024 Category: Dermatology Tags: Editors' Picks Source Type: research

Romidepsin and Afatinib Abrogate Jak –Signal Transducer and Activator of Transcription Signaling and Elicit Synergistic Antitumor Effects in Cutaneous T-Cell Lymphoma
In this study, we demonstrate that the combination of romidepsin, a selective class I histone deacetylase inhibitor, with afatinib, an EGFR family inhibitor, induces strongly synergistic antitumor effects in cutaneous T-cell lymphoma models in  vitro and in vivo through abrogation of Jak–signal transducer and activator of transcription signaling. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - January 12, 2024 Category: Dermatology Authors: Bobby B. Shih, Cindy Ma, Jose R. Cortes, Clara Reglero, Hannah Miller, S. Aidan Quinn, Robert Albero, Anouchka P. Laurent, Adam Mackey, Adolfo A. Ferrando, Larisa Geskin, Teresa Palomero Tags: Original Article Source Type: research

Romidepsin and afatinib abrogate JAK-STAT signaling and elicit synergistic antitumor effects in cutaneous T-cell lymphoma
Cutaneous T-cell lymphomas (CTCL) are mature lymphoid neoplasias resulting from the malignant transformation of skin-resident T cells. A distinctive clinical feature of CTCL is their sensitivity to treatment with histone deacetylase (HDAC) inhibitors. However, responses to HDAC inhibitor therapy are universally transient and non-curative, highlighting the need for effective and durable drug combinations. Here we demonstrate that the combination of romidepsin, a selective class I HDAC inhibitor, with afatinib, an epidermal growth factor receptor (EGFR) family inhibitor, induces strongly synergistic antitumor effects in CTCL...
Source: Journal of Investigative Dermatology - January 12, 2024 Category: Dermatology Authors: Bobby B. Shih, Cindy Ma, Jose R. Cortes, Clara Reglero, Hannah Miller, S. Aidan Quinn, Robert Albero, Anouchka P. Laurent, Adam Mackey, Adolfo A. Ferrando, Larisa Geskin, Teresa Palomero Tags: Original Article Source Type: research