Human skin T cells express conserved T cell receptors that cross-react with staphylococcal superantigens and CD1a

Human Langerhans cells highly express CD1a antigen presenting molecules. To understand the functions of CD1a in human skin, we used CD1a tetramers to capture T cells and determine their effector functions and T cell receptor patterns. Skin T cells from all donors showed CD1a tetramer staining, which in three cases exceeded 10% of skin T cells. CD1a tetramer+ T cells produced diverse cytokines, including interleukins 2, 4, 5, 9, 17, 22 and IFN γ. Conserved T cell receptors (TCRs) often recognize nonpolymorphic antigen presenting molecules, but no TCR motifs are known for CD1a.

Source: Journal of Investigative Dermatology - November 9, 2023 Category: Dermatology Authors: Elizabeth Bryan, Jessica E. Teague, Sezin Eligul, Wellington C. Arkins, D. Branch Moody, Rachael A. Clark, Ildiko Van Rhijn Tags: Original Article Source Type: research