Biovalorisation of crude glycerol and xylose into xylitol by oleaginous yeast Yarrowia lipolytica
Xylitol is a commercially important chemical with multiple applications in the food and pharmaceutical industries. According to the US Department of Energy, xylitol is one of the top twelve platform chemicals ... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - June 3, 2020 Category: Microbiology Authors: Ashish A. Prabhu, Dominic J. Thomas, Rodrigo Ledesma-Amaro, Gary A. Leeke, Angel Medina, Carol Verheecke-Vaessen, Frederic Coulon, Deepti Agrawal and Vinod Kumar Tags: Research Source Type: research

Exploiting bacterial outer membrane vesicles as a cross-protective vaccine candidate against avian pathogenic Escherichia coli (APEC)
The well-known fact that avian pathogenic Escherichia coli (APEC) is harder to prevent due to its numerous serogroups has promoted the development of biological immunostimulatory materials as new vaccine candidat... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - June 3, 2020 Category: Microbiology Authors: Rujiu Hu, Jing Li, Yuezhen Zhao, Hua Lin, Liu Liang, Mimi Wang, Haojing Liu, Yuna Min, Yupeng Gao and Mingming Yang Tags: Research Source Type: research

Obtaining a series of native gradient promoter-5 ′-UTR sequences in Corynebacterium glutamicum ATCC 13032
Corynebacterium glutamicum is an important industrial microorganism used for the production of many valuable compounds, especially amino acids and their derivatives. For fine-tuning of metabolic pathways, synthet... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - June 3, 2020 Category: Microbiology Authors: Ning Li, Weizhu Zeng, Sha Xu and Jingwen Zhou Tags: Research Source Type: research

Coiled-coil inspired functional inclusion bodies
Recombinant protein expression in bacteria often leads to the formation of intracellular insoluble protein deposits, a major bottleneck for the production of soluble and active products. However, in recent yea... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - June 1, 2020 Category: Microbiology Authors: Marcos Gil-Garcia, Susanna Navarro and Salvador Ventura Tags: Research Source Type: research

Optimization of hydrogenobyrinic acid biosynthesis in Escherichia coli using multi-level metabolic engineering strategies
Hydrogenobyrinic acid is a key intermediate of the de-novo aerobic biosynthesis pathway of vitamin B12. The introduction of a heterologous de novo vitamin B12 biosynthesis pathway in Escherichia coli offers an al... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - June 1, 2020 Category: Microbiology Authors: Pingtao Jiang, Huan Fang, Jing Zhao, Huina Dong, Zhaoxia Jin and Dawei Zhang Tags: Research Source Type: research

Development of a whole-cell biocatalyst for diisobutyl phthalate degradation by functional display of a carboxylesterase on the surface of Escherichia coli
Phthalic acid esters (PAEs) are widely used as plasticizers or additives during the industrial manufacturing of plastic products. PAEs have been detected in both aquatic and terrestrial environments due to the... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - May 29, 2020 Category: Microbiology Authors: Junmei Ding, Yang Zhou, Chaofan Wang, Zheng Peng, Yuelin Mu, Xianghua Tang and Zunxi Huang Tags: Research Source Type: research

High-yield production of l-serine through a novel identified exporter combined with synthetic pathway in Corynebacterium glutamicum
l-Serine has wide and increasing applications in industries with fast-growing market demand. Although strategies for achieving and improving l-serine production in Corynebacterium glutamicum (C. glutamicum) have ... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - May 29, 2020 Category: Microbiology Authors: Xiaomei Zhang, Yujie Gao, Ziwei Chen, Guoqiang Xu, Xiaojuan Zhang, Hui Li, Jinsong Shi, Mattheos A. G. Koffas and Zhenghong Xu Tags: Research Source Type: research

Escherichia coli metabolism under short-term repetitive substrate dynamics: adaptation and trade-offs
Microbial metabolism is highly dependent on the environmental conditions. Especially, the substrate concentration, as well as oxygen availability, determine the metabolic rates. In large-scale bioreactors, mic... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - May 29, 2020 Category: Microbiology Authors: Eleni Vasilakou, Mark C. M. van Loosdrecht and S. Aljoscha Wahl Tags: Research Source Type: research

Enhanced production of recombinant proteins in Corynebacterium glutamicum by constructing a bicistronic gene expression system
Corynebacterium glutamicum is a traditional food-grade industrial microorganism, in which an efficient endotoxin-free recombinant protein expression factory is under developing in recent years. However, the intri... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - May 26, 2020 Category: Microbiology Authors: Manman Sun, Xiong Gao, Zihao Zhao, An Li, Yali Wang, Yankun Yang, Xiuxia Liu and Zhonghu Bai Tags: Research Source Type: research

Efficient production of myo-inositol in Escherichia coli through metabolic engineering
The biosynthesis of high value-added compounds using metabolically engineered strains has received wide attention in recent years. Myo-inositol (inositol), an important compound in the pharmaceutics, cosmetics... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - May 24, 2020 Category: Microbiology Authors: Ran You, Lei Wang, Congrong Shi, Hao Chen, Shasha Zhang, Meirong Hu and Yong Tao Tags: Research Source Type: research

Biosynthesis of aromatic polyketides in microorganisms using type II polyketide synthases
Aromatic polyketides have attractive biological activities and pharmacological properties. Different from other polyketides, aromatic polyketides are characterized by their polycyclic aromatic structure. The b... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - May 24, 2020 Category: Microbiology Authors: Jia Wang, Ruihua Zhang, Xin Chen, Xinxiao Sun, Yajun Yan, Xiaolin Shen and Qipeng Yuan Tags: Review Source Type: research

Heterologous reconstitution of the biosynthesis pathway for 4-demethyl-premithramycinone, the aglycon of antitumor polyketide mithramycin
Mithramycin is an anti-tumor compound of the aureolic acid family produced by Streptomyces argillaceus. Its biosynthesis gene cluster has been cloned and characterized, and several new analogs with improved pharm... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - May 24, 2020 Category: Microbiology Authors: Daniel Zabala, Lijiang Song, Yousef Dashti, Gregory L. Challis, Jos é A. Salas and Carmen Méndez Tags: Research Source Type: research

The signal peptide of Cry1Ia can improve the expression of eGFP or mCherry in Escherichia coli and Bacillus thuringiensis and enhance the host ’s fluorescent intensity
The signal peptides (SPs) of secretory proteins are frequently used or modified to guide recombinant proteins outside the cytoplasm of prokaryotic cells. In the periplasmic space and extracellular environment,... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - May 24, 2020 Category: Microbiology Authors: Jianhua Gao, Hongmei Qian, Xiaoqin Guo, Yi Mi, Junpei Guo, Juanli Zhao, Chao Xu, Ting Zheng, Ming Duan, Zhongwei Tang, Chaoyang Lin, Zhicheng Shen, Yiwei Jiang and Xingchun Wang Tags: Research Source Type: research

Homology-dependent recombination of large synthetic pathways into E. coli genome via λ-Red and CRISPR/Cas9 dependent selection methodology
Metabolic engineering frequently needs genomic integration of many heterologous genes for biosynthetic pathway assembly. Despite great progresses in genome editing for the model microorganism Escherichia coli, th... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - May 24, 2020 Category: Microbiology Authors: Buli Su, Dandan Song and Honghui Zhu Tags: Research Source Type: research

Identification of new arylamine N-acetyltransferases and enhancing 2-acetamidophenol production in Pseudomonas chlororaphis HT66
2-Acetamidophenol (AAP) is an aromatic compound with the potential for antifungal, anti-inflammatory, antitumor, anti-platelet, and anti-arthritic activities. Due to the biosynthesis of AAP is not yet fully un... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - May 19, 2020 Category: Microbiology Authors: Shuqi Guo, Yunxiao Wang, Wei Wang, Hongbo Hu and Xuehong Zhang Tags: Research Source Type: research

The functional capacity of plantaricin-producing Lactobacillus plantarum SF9C and S-layer-carrying Lactobacillus brevis SF9B to withstand gastrointestinal transit
We evaluated the functional capacity of plantaricin-producing Lactobacillus plantarum SF9C and S-layer-carrying Lactobacillus brevis SF9B to withstand gastrointestinal transit and to compete among the gut microbi... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - May 19, 2020 Category: Microbiology Authors: Katarina Butorac, Martina Bani ć, Jasna Novak, Andreja Leboš Pavunc, Ksenija Uroić, Ksenija Durgo, Nada Oršolić, Marina Kukolj, Slobodanka Radović, Simone Scalabrin, Jurica Žučko, Antonio Starčević, Jagoda Šušković and Blaženka Kos Tags: Research Source Type: research

Key factors affecting ammonium production by an Azotobacter vinelandii strain deregulated for biological nitrogen fixation
The obligate aerobe Azotobacter vinelandii is a model organism for the study of biological nitrogen fixation (BNF). This bacterium regulates the process of BNF through the two component NifL and NifA system, wher... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - May 19, 2020 Category: Microbiology Authors: Mary H. Plunkett, Carolann M. Knutson and Brett M. Barney Tags: Research Source Type: research

Valorization of Gelidium amansii for dual production of D-galactonic acid and 5-hydroxymethyl-2-furancarboxylic acid by chemo-biological approach
Marine macroalgae Gelidium amansii is a promising feedstock for production of sustainable biochemicals to replace petroleum and edible biomass. Different from terrestrial lignocellulosic biomass, G. amansii is co... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - May 14, 2020 Category: Microbiology Authors: Peng Liu, Jiaxiao Xie, Huanghong Tan, Feng Zhou, Lihua Zou and Jia Ouyang Tags: Research Source Type: research

High-level production of poly- γ-glutamic acid from untreated molasses by Bacillus siamensis IR10
Poly- γ-glutamic acid (γ-PGA) is a promising biopolymer and has been applied in many fields. Bacillus siamensis SB1001 was a newly isolated poly-γ-glutamic acid producer with sucrose as its optimal carbon source. ... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - May 12, 2020 Category: Microbiology Authors: Dexin Wang, Hyangmi Kim, Sungbeom Lee, Dae-Hyuk Kim and Min-Ho Joe Tags: Research Source Type: research

Engineering central pathways for industrial-level (3R)-acetoin biosynthesis in Corynebacterium glutamicum
Acetoin, especially the optically pure (3S)- or (3R)-enantiomer, is a high-value-added bio-based platform chemical and important potential pharmaceutical intermediate. Over the past decades, intense efforts have ... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - May 12, 2020 Category: Microbiology Authors: Lingxue Lu, Yufeng Mao, Mengyun Kou, Zhenzhen Cui, Biao Jin, Zhishuai Chang, Zhiwen Wang, Hongwu Ma and Tao Chen Tags: Research Source Type: research

In vitro and in vivo recombination of heterologous modules for improving biosynthesis of astaxanthin in yeast
Astaxanthin is a kind of tetraterpene and has strong antioxygenic property. The biosynthesis of astaxanthin in engineered microbial chassis has greater potential than its chemical synthesis and extraction from... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - May 12, 2020 Category: Microbiology Authors: Dan-Dan Qi, Jin Jin, Duo Liu, Bin Jia and Ying-Jin Yuan Tags: Research Source Type: research

Secretion of a low and high molecular weight β-glycosidase by Yarrowia lipolytica
The secretory production of recombinant proteins in yeast simplifies isolation and purification but also faces possible complications due to the complexity of the secretory pathway. Therefore, correct folding,... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - May 11, 2020 Category: Microbiology Authors: Paul Swietalski, Frank Hetzel, Ines Seitl and Lutz Fischer Tags: Research Source Type: research

Comprehensive dissection of dispensable genomic regions in Streptomyces based on comparative analysis approach
Large-scale genome reduction has been performed to significantly improve the performance of microbial chassis. Identification of the essential or dispensable genes is pivotal for genome reduction to avoid synt... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - May 6, 2020 Category: Microbiology Authors: Qing-Ting Bu, Yue-Ping Li, Huang Xie, Jue Wang, Zi-Yue Li, Xin-Ai Chen, Xu-Ming Mao and Yong-Quan Li Tags: Research Source Type: research

Novel enterocin E20c purified from Enterococcus hirae 20c synergised with ß-lactams and ciprofloxacin against Salmonella enterica
An increasing rate of antibiotic resistance among Gram-negative bacterial pathogens has created an urgent need to discover novel therapeutic agents to combat infectious diseases. Use of bacteriocins as therape... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - May 4, 2020 Category: Microbiology Authors: Preeti Sharma, Muzamil Rashid and Sukhraj Kaur Tags: Research Source Type: research

Functional expression of polyethylene terephthalate-degrading enzyme (PETase) in green microalgae
For decades, plastic has been a valuable global product due to its convenience and low price. For example, polyethylene terephthalate (PET) was one of the most popular materials for disposable bottles due to i... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - April 28, 2020 Category: Microbiology Authors: Ji Won Kim, Su-Bin Park, Quynh-Giao Tran, Dae-Hyun Cho, Dong-Yun Choi, Yong Jae Lee and Hee-Sik Kim Tags: Research Source Type: research

Co-production of gallic acid and a novel cell-associated tannase by a pigment-producing yeast, Sporidiobolus ruineniae A45.2
Gallic acid has received a significant amount of interest for its biological properties. Thus, there have been recent attempts to apply this substance in various industries and in particular the feed industry.... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - April 25, 2020 Category: Microbiology Authors: Apinun Kanpiengjai, Chartchai Khanongnuch, Saisamorn Lumyong, Dietmar Haltrich, Thu-Ha Nguyen and Suwapat Kittibunchakul Tags: Research Source Type: research

Engineering of sugar transporters for improvement of xylose utilization during high-temperature alcoholic fermentation in Ogataea polymorpha yeast
Xylose transport is one of the bottlenecks in the conversion of lignocellulosic biomass to ethanol. Xylose consumption by the wild-type strains of xylose-utilizing yeasts occurs once glucose is depleted result... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - April 25, 2020 Category: Microbiology Authors: Roksolana Vasylyshyn, Olena Kurylenko, Justyna Ruchala, Nadiya Shevchuk, Neringa Kuliesiene, Galina Khroustalyova, Alexander Rapoport, Rimantas Daugelavicius, Kostyantyn Dmytruk and Andriy Sibirny Tags: Research Source Type: research

CRISPR/Cas9-deaminase enables robust base editing in Rhodobacter sphaeroides 2.4.1
CRISPR/Cas9 systems have been repurposed as canonical genome editing tools in a variety of species, but no application for the model strain Rhodobacter sphaeroides 2.4.1 was unveiled. (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - April 25, 2020 Category: Microbiology Authors: Yufeng Luo, Mei Ge, Bolun Wang, Changhong Sun, Junyi Wang, Yuyang Dong and Jianzhong Jeff Xi Tags: Research Source Type: research

Engineered butyrate-producing bacteria prevents high fat diet-induced obesity in mice
Obesity is a major problem worldwide and severely affects public safety. As a metabolite of gut microbiota, endogenous butyric acid participates in energy and material metabolism. Considering the serious side ... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - April 25, 2020 Category: Microbiology Authors: Liang Bai, Mengxue Gao, Xiaoming Cheng, Guangbo Kang, Xiaocang Cao and He Huang Tags: Research Source Type: research

Synthesis of the character impact compound raspberry ketone and additional flavoring phenylbutanoids of biotechnological interest with Corynebacterium glutamicum
The phenylbutanoid 4-(4-hydroxyphenyl)butan-2-one, commonly known as raspberry ketone, is responsible for the typical scent and flavor of ripe raspberries. Chemical production of nature-identical raspberry ket... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - April 21, 2020 Category: Microbiology Authors: Lars Milke, Mario Mutz and Jan Marienhagen Tags: Research Source Type: research

Repeated fed-batch strategy and metabolomic analysis to achieve high docosahexaenoic acid productivity in Crypthecodinium cohnii
Docosahexaenoic acid (DHA) is essential for human diet. However, high production cost of DHA using C. cohnii makes it currently less competitive commercially, which is mainly caused by low DHA productivity. In re... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - April 16, 2020 Category: Microbiology Authors: Liangsen Liu, Fangzhong Wang, Guangsheng Pei, Jinyu Cui, Jinjin Diao, Mingming Lv, Lei Chen and Weiwen Zhang Tags: Research Source Type: research

Ethylene glycol and glycolic acid production from xylonic acid by Enterobacter cloacae
Biological routes for ethylene glycol production have been developed in recent years by constructing the synthesis pathways in different microorganisms. However, no microorganisms have been reported yet to pro... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - April 15, 2020 Category: Microbiology Authors: Zhongxi Zhang, Yang Yang, Yike Wang, Jinjie Gu, Xiyang Lu, Xianyan Liao, Jiping Shi, Chul Ho Kim, Gary Lye, Frank Baganz and Jian Hao Tags: Research Source Type: research

Gut microbial dysbiosis in individuals with Sj ögren’s syndrome
In this study, the gut microbiome was evaluated in individuals with dry eye and bacterial compositions were correlated to dry eye (D... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - April 15, 2020 Category: Microbiology Authors: Roberto Mendez, Arjun Watane, Monika Farhangi, Kara M. Cavuoto, Tom Leith, Shrish Budree, Anat Galor and Santanu Banerjee Tags: Research Source Type: research

Improving production of Streptomyces griseus trypsin for enzymatic processing of insulin precursor
Trypsin has many applications in food and pharmaceutical manufacturing. Although commercial trypsin is usually extracted from porcine pancreas, this source carries the risks of infectivity and immunogenicity. ... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - April 13, 2020 Category: Microbiology Authors: Yunfeng Zhang, Qixing Liang, Chuanzhi Zhang, Juan Zhang, Guocheng Du and Zhen Kang Tags: Research Source Type: research

Increased production of periplasmic proteins in Escherichia coli by directed evolution of the translation initiation region
Recombinant proteins are often engineered with an N-terminal signal peptide, which facilitates their secretion to the oxidising environment of the periplasm (gram-negative bacteria) or the culture supernatant ... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - April 7, 2020 Category: Microbiology Authors: Kiavash Mirzadeh, Patrick J. Shilling, Rageia Elfageih, Alister J. Cumming, Huanhuan L. Cui, Maja Rennig, Morten H. H. N ørholm and Daniel O. Daley Tags: Research Source Type: research

Current developments on polyhydroxyalkanoates synthesis by using halophiles as a promising cell factory
Plastic pollution is a severe threat to our environment which necessitates implementation of bioplastics to realize sustainable development for a green world. Polyhydroxyalkanoates (PHA) represent one of the p... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - April 7, 2020 Category: Microbiology Authors: Ruchira Mitra, Tong Xu, Hua Xiang and Jing Han Tags: Review Source Type: research

Efficient production of (S)-1-phenyl-1,2-ethanediol using xylan as co-substrate by a coupled multi-enzyme Escherichia coli system
(S)-1-phenyl-1,2-ethanediol is an important chiral intermediate in the synthesis of liquid crystals and chiral biphosphines. (S)-carbonyl reductase II from Candida parapsilosis catalyzes the conversion of 2-hydro... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - April 7, 2020 Category: Microbiology Authors: Junchao Rao, Rongzhen Zhang, Guanyu Xu, Lihong Li and Yan Xu Tags: Research Source Type: research

Recombinant protein production associated growth inhibition results mainly from transcription and not from translation
Recombinant protein production can be stressful to the host organism. The extent of stress is determined by the specific properties of the recombinant transcript and protein, by the rates of transcription and ... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - April 6, 2020 Category: Microbiology Authors: Zhaopeng Li and Ursula Rinas Tags: Research Source Type: research

A novel fungal beta-propeller phytase from nematophagous Arthrobotrys oligospora: characterization and potential application in phosphorus and mineral release for feed processing
Phytases are widely utilized in feed industry to increase the utilization of phosphorus, minerals, and amino acids for improvement of animal and human nutrition. At present, all known β-propeller phytases (BPP... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - April 6, 2020 Category: Microbiology Authors: Xianjuan Hou, Zhen Shen, Na Li, Xiaowei Kong, Kangliang Sheng, Jingmin Wang and Yongzhong Wang Tags: Research Source Type: research

Improving cytosolic aspartate biosynthesis increases glucoamylase production in Aspergillus niger under oxygen limitation
Glucoamylase is one of the most industrially applied enzymes, produced by Aspergillus species, like Aspergillus niger. Compared to the traditional ways of process optimization, the metabolic engineering strategie... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - April 3, 2020 Category: Microbiology Authors: Weiqiang Cao, Guan Wang, Hongzhong Lu, Liming Ouyang, Ju Chu, Yufei Sui and Yingping Zhuang Tags: Research Source Type: research

Impact of lignans in oilseed mix on gut microbiome composition and enterolignan production in younger healthy and premenopausal women: an in vitro pilot study
Dietary lignans belong to the group of phytoestrogens together with coumestans, stilbenes and isoflavones, and themselves do not exhibit oestrogen-like properties. Nonetheless, the gut microbiota converts them... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - April 3, 2020 Category: Microbiology Authors: Giulia Corona, Anna Kreimes, Monica Barone, Silvia Turroni, Patrizia Brigidi, Enver Keleszade and Adele Costabile Tags: Research Source Type: research

Enhancing the bioconversion of phytosterols to steroidal intermediates by the deficiency of kasB in the cell wall synthesis of Mycobacterium neoaurum
The bioconversion of phytosterols into high value-added steroidal intermediates, including the 9 α-hydroxy-4-androstene-3,17-dione (9-OHAD) and 22-hydroxy-23,24-bisnorchol-4-ene-3-one (4-HBC), is the cornerstone i... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - March 30, 2020 Category: Microbiology Authors: Liang-Bin Xiong, Hao-Hao Liu, Ming Zhao, Yong-Jun Liu, Lu Song, Zhi-Yong Xie, Yi-Xin Xu, Feng-Qing Wang and Dong-Zhi Wei Tags: Research Source Type: research

Genetic engineering of non-native hosts for 1-butanol production and its challenges: a review
Owing to the increase in energy consumption, fossil fuel resources are gradually depleting which has led to the growing environmental concerns; therefore, scientists are being urged to produce sustainable and ... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - March 27, 2020 Category: Microbiology Authors: Said Nawab, Ning Wang, Xiaoyan Ma and Yi-Xin Huo Tags: Review Source Type: research

Expression of Concern to: Drug metabolite synthesis by immobilized human FMO3 and whole cell catalysts
Expression of Concern. (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - March 25, 2020 Category: Microbiology Authors: Chongliang Gao and Tingjie Zheng Tags: Publisher Correction Source Type: research

Disruption or reduced expression of the orotidine-5 ′-decarboxylase gene pyrG increases citric acid production: a new discovery during recyclable genome editing in Aspergillus niger
Aspergillus niger is a filamentous fungus used for the majority of global citric acid production. Recent developments in genome editing now enable biotechnologists to engineer and optimize A. niger. Currently, ho... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - March 24, 2020 Category: Microbiology Authors: Lihui Zhang, Xiaomei Zheng, Timothy C. Cairns, Zhidan Zhang, Depei Wang, Ping Zheng and Jibin Sun Tags: Research Source Type: research

Characterization of a novel family VIII esterase EstM2 from soil metagenome capable of hydrolyzing estrogenic phthalates
Microbes are rich sources of enzymes and esterases are one of the most important classes of enzymes because of their potential for application in the field of food, agriculture, pharmaceuticals and bioremediat... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - March 24, 2020 Category: Microbiology Authors: Jayita Sarkar, Arindam Dutta, Piyali Pal Chowdhury, Joydeep Chakraborty and Tapan K. Dutta Tags: Research Source Type: research

Type 2 diabetes induced microbiome dysbiosis is associated with therapy resistance in pancreatic adenocarcinoma
Resistance to therapy is one of the major factors that contribute to dismal survival statistics in pancreatic cancer. While there are many tumor intrinsic and tumor microenvironment driven factors that contrib... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - March 24, 2020 Category: Microbiology Authors: Kousik Kesh, Roberto Mendez, Leila Abdelrahman, Santanu Banerjee and Sulagna Banerjee Tags: Research Source Type: research

Synthesis of acridone derivatives via heterologous expression of a plant type III polyketide synthase in Escherichia coli
Acridone alkaloids are heterocyclic compounds that exhibit a broad-range of pharmaceutical and chemotherapeutic activities, including anticancer, antiviral, anti-inflammatory, antimalarial, and antimicrobial e... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - March 20, 2020 Category: Microbiology Authors: Gyu-Sik Choi, Hye Jeong Choo, Bong-Gyu Kim and Joong-Hoon Ahn Tags: Research Source Type: research

Production of drug metabolites by human FMO3 in Escherichia coli
In the course of drug discovery and development process, sufficient reference standards of drug metabolites are required, especially for preclinical/clinical or new therapeutic drugs. Whole-cell synthesis of d... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - March 20, 2020 Category: Microbiology Authors: Gianluca Catucci, Gianfranco Gilardi and Sheila J. Sadeghi Tags: Research Source Type: research

Identification and engineering of 32 membered antifungal macrolactone notonesomycins
Notonesomycin A is a 32-membered bioactive glycosylated macrolactone known to be produced by Streptomyces aminophilus subsp. notonesogenes 647-AV1 and S. aminophilus DSM 40186. In a high throughput antifungal scr... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - March 19, 2020 Category: Microbiology Authors: Falicia Goh, Mingzi M. Zhang, Tian Ru Lim, Kia Ngee Low, Choy Eng Nge, Elena Heng, Wan Lin Yeo, Fernanda L. Sirota, Sharon Crasta, Zann Tan, Veronica Ng, Chung Yan Leong, Huibin Zhang, Alexander Lezhava, Swaine L. Chen, Shawn S. Hoon & hellip; Tags: Research Source Type: research