The Efficiency and Toxicity Of Anlotinib in Combination With Docetaxel Followed by Epirubicin and Cyclophosphamide Regimen as Neoadjuvant Treatment in IIB to IIIA Triple Negative Breast Cancer: A Single-Arm, Multicenter, Open-Label, Phase II Study
CONCLUSION: The combination of anlotinib and EC-T chemotherapy demonstrated tolerable side effects in the neoadjuvant treatment of early TNBC. pCR was higher than what has been reported in previous clinical studies of chemotherapy alone. This study provides additional rationale for using anlotinib plus docetaxel-epirubicin-based chemotherapy regimen in patients with early-stage TNBCs.PMID:38670862 | DOI:10.1016/j.clbc.2024.01.018 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - April 26, 2024 Category: Cancer & Oncology Authors: Xi Chen Xinyu Wei Peizhuo Yao Yanbin Liu Haitao Guan Huafeng Kang Di Liu Yan Diao Xiaobin Ma Weili Min Changyou Shan Yang Zhao Fang Zhao Yuanyuan Chen Dong Xiao Qing She Youhuai Liu Yinbin Zhang Shuqun Zhang Source Type: research
Hangeshashinto Inhibits < em > Porphyromonas gingivalis < /em > Pathogen-Associated Molecular Patterns-Mediated IL-6 and IL-8 Production through Toll-Like Receptors in CAL27 Cells
This study suggests that the anti-inflammatory effects of hangeshashinto may be attributed to the inhibition of TLR signal transduction pathways including NF-κB activation, thereby suppressing NF-κB-dependent gene expression.PMID:38665937 | PMC:PMC11045287 | DOI:10.1155/2024/9866670 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - April 26, 2024 Category: Complementary Medicine Authors: Hourei Oh Yoshimasa Makita Kazuya Masuno Yasuhiro Imamura Source Type: research
Calcitriol Treatment Decreases Cell Migration, Viability and β-Catenin Signaling in Oral Dysplasia
Curr Issues Mol Biol. 2024 Apr 2;46(4):3050-3062. doi: 10.3390/cimb46040191.ABSTRACTNearly 90% of oral cancers are characterized as oral squamous cell carcinoma (OSCC), representing the sixth most common type of cancer. OSCC usually evolves from oral potentially malignant disorders that, in some cases, are histologically consistent with a oral dysplasia. The levels of 1α,25 dihydroxyvitamin D3 (1,25-(OH)2D3; calcitriol), the active form of vitamin D3, have been shown to be decreased in patients with oral dysplasia and OSCC. Moreover, treatment with 1,25-(OH)2D3 has been proven beneficial in OSCC by inhibiting the Wnt/β-c...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Daniel Pe ña-Oyarzún Constanza Guzm án Catalina Kretschmar Vicente A Torres Andrea Maturana-Ramirez Juan Aitken Montserrat Reyes Source Type: research
Frankincense ( < em > Boswellia serrata < /em > ) Extract Effects on Growth and Biofilm Formation of < em > Porphyromonas gingivalis < /em > , and Its Intracellular Infection in Human Gingival Epithelial Cells
Curr Issues Mol Biol. 2024 Mar 30;46(4):2991-3004. doi: 10.3390/cimb46040187.ABSTRACTFrankincense is produced by Boswellia trees, which can be found throughout the Middle East and parts of Africa and Asia. Boswellia serrata extract has been shown to have anti-cancer, anti-inflammatory, and antimicrobial effects. Periodontitis is an oral chronic inflammatory disease that affects nearly half of the US population. We investigated the antimicrobial effects of B. serrata extract on two oral pathogens associated with periodontitis. Using the minimum inhibitory concentration and crystal violet staining methods, we demonstrated th...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: David Vang Aline Cristina Abreu Moreira-Souza Nicholas Zusman German Moncada Harmony Matshik Dakafay Homer Asadi David M Ojcius Cassio Luiz Coutinho Almeida-da-Silva Source Type: research
Efficacy and safety of combined anlotinib-oral etoposide treatment for patients with platinum-resistant ovarian cancer
CONCLUSION: Anlotinib combined with etoposide emerged effective for the treatment of PROC.PMID:38670563 | DOI:10.3802/jgo.2024.35.e100 (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - April 26, 2024 Category: OBGYN Authors: Shuai Huang Guihua Sheng Qiubo Lv Ye Li Qingwei Meng Xuexiao Gao Zhiyuan Shang Source Type: research
Interdisciplinary Collaboration in Head and Neck Cancer Care: Optimizing Oral Health Management for Patients Undergoing Radiation Therapy
In conclusion, these proactive measures help minimize dental and oral complications before, during, and after treatment.PMID:38668058 | PMC:PMC11049200 | DOI:10.3390/curroncol31040155 (Source: Current Oncology)
Source: Current Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Tugce Kutuk Ece Atak Alessandro Villa Noah S Kalman Adeel Kaiser Source Type: research
Hangeshashinto Inhibits < em > Porphyromonas gingivalis < /em > Pathogen-Associated Molecular Patterns-Mediated IL-6 and IL-8 Production through Toll-Like Receptors in CAL27 Cells
This study suggests that the anti-inflammatory effects of hangeshashinto may be attributed to the inhibition of TLR signal transduction pathways including NF-κB activation, thereby suppressing NF-κB-dependent gene expression.PMID:38665937 | PMC:PMC11045287 | DOI:10.1155/2024/9866670 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - April 26, 2024 Category: Complementary Medicine Authors: Hourei Oh Yoshimasa Makita Kazuya Masuno Yasuhiro Imamura Source Type: research
Calcitriol Treatment Decreases Cell Migration, Viability and β-Catenin Signaling in Oral Dysplasia
Curr Issues Mol Biol. 2024 Apr 2;46(4):3050-3062. doi: 10.3390/cimb46040191.ABSTRACTNearly 90% of oral cancers are characterized as oral squamous cell carcinoma (OSCC), representing the sixth most common type of cancer. OSCC usually evolves from oral potentially malignant disorders that, in some cases, are histologically consistent with a oral dysplasia. The levels of 1α,25 dihydroxyvitamin D3 (1,25-(OH)2D3; calcitriol), the active form of vitamin D3, have been shown to be decreased in patients with oral dysplasia and OSCC. Moreover, treatment with 1,25-(OH)2D3 has been proven beneficial in OSCC by inhibiting the Wnt/β-c...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Daniel Pe ña-Oyarzún Constanza Guzm án Catalina Kretschmar Vicente A Torres Andrea Maturana-Ramirez Juan Aitken Montserrat Reyes Source Type: research
Frankincense ( < em > Boswellia serrata < /em > ) Extract Effects on Growth and Biofilm Formation of < em > Porphyromonas gingivalis < /em > , and Its Intracellular Infection in Human Gingival Epithelial Cells
Curr Issues Mol Biol. 2024 Mar 30;46(4):2991-3004. doi: 10.3390/cimb46040187.ABSTRACTFrankincense is produced by Boswellia trees, which can be found throughout the Middle East and parts of Africa and Asia. Boswellia serrata extract has been shown to have anti-cancer, anti-inflammatory, and antimicrobial effects. Periodontitis is an oral chronic inflammatory disease that affects nearly half of the US population. We investigated the antimicrobial effects of B. serrata extract on two oral pathogens associated with periodontitis. Using the minimum inhibitory concentration and crystal violet staining methods, we demonstrated th...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: David Vang Aline Cristina Abreu Moreira-Souza Nicholas Zusman German Moncada Harmony Matshik Dakafay Homer Asadi David M Ojcius Cassio Luiz Coutinho Almeida-da-Silva Source Type: research
Efficacy and safety of combined anlotinib-oral etoposide treatment for patients with platinum-resistant ovarian cancer
CONCLUSION: Anlotinib combined with etoposide emerged effective for the treatment of PROC.PMID:38670563 | DOI:10.3802/jgo.2024.35.e100 (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - April 26, 2024 Category: OBGYN Authors: Shuai Huang Guihua Sheng Qiubo Lv Ye Li Qingwei Meng Xuexiao Gao Zhiyuan Shang Source Type: research
Interdisciplinary Collaboration in Head and Neck Cancer Care: Optimizing Oral Health Management for Patients Undergoing Radiation Therapy
In conclusion, these proactive measures help minimize dental and oral complications before, during, and after treatment.PMID:38668058 | PMC:PMC11049200 | DOI:10.3390/curroncol31040155 (Source: Current Oncology)
Source: Current Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Tugce Kutuk Ece Atak Alessandro Villa Noah S Kalman Adeel Kaiser Source Type: research
Intratumoral therapies in head and neck squamous cell carcinoma: A systematic review and future perspectives
Head and neck squamous cell carcinoma (HNSCC) constitute a diverse category of cancer sites, encompassing oral cavity, pharynx, larynx, nasal cavity, and paranasal sinuses [1].These malignancies represent a significant global health challenge, affecting countries at various levels of development. According to data from The Global Cancer Observatory (GLOBOCAN) in 2020, HNSCC ranked as the seventh most common cancer worldwide [2]. Projections for 2030 predict an alarming global rise, primarily driven by tumors associated with the human papillomavirus (HPV)[1]. (Source: Cancer Treatment Reviews)
Source: Cancer Treatment Reviews - April 26, 2024 Category: Cancer & Oncology Authors: Pablo Jim énez-Labaig, Antonio Rullan, Irene Braña, Alberto Hernando-Calvo, Victor Moreno, Bernard Doger, George Bitar, Derfel Ap Dafydd, Alan Melcher, Kevin J. Harrington Tags: Anti-tumour Treatment Source Type: research
Retraction Note: Silencing POLE2 promotes apoptosis and inhibits proliferation of oral squamous cell carcinomas by inhibiting PI3K/AKT signaling pathway
(Source: Medical Oncology)
Source: Medical Oncology - April 26, 2024 Category: Cancer & Oncology Source Type: research
AKR1B10 accelerates glycolysis through binding HK2 to promote the malignant progression of oral squamous cell carcinoma
ConclusionTo sum up, AKR1B10 could bind to HK2 to accelerate glycolysis, thereby facilitating the proliferation, migration, invasion and EMT of OSCC cells. (Source: Hormones and Cancer)
Source: Hormones and Cancer - April 26, 2024 Category: Cancer & Oncology Source Type: research
Mapping the landscape of oral cancer research trends: a systematic scientometric review of global efforts
ConclusionThis scientometric analysis is a valuable resource for researchers, funding agencies, industry, and institutions, offering guidance and insights.Clinical trial numberNot Applicable. (Source: Oral and Maxillofacial Surgery)
Source: Oral and Maxillofacial Surgery - April 26, 2024 Category: ENT & OMF Source Type: research
