Association of menopause, aging and treatment procedures with positive margins after therapeutic cervical conization for CIN 3: a retrospective study of 8,856 patients by the Japan Society of Obstetrics and Gynecology
This study aimed to determine the predictive factors for positive surgical margins in cervical intraepithelial neoplasia grade 3 (CIN 3) patients after therapeutic cervical conization and those for positive margins in patients who did not experience recurrence and did not undergo additional treatment.METHODS: In 2009 and 2013, 14,832 patients underwent cervical conization at 205 institutions in Japan. Of these, 8856 patients who underwent therapeutic conization fulfilled the inclusion criteria. Their histologic findings and clinical outcomes were evaluated based on standard statistical procedures and clinical and demograph...
Source: Journal of Gynecologic Oncology - June 16, 2021 Category: OBGYN Authors: Masae Ikeda Mikio Mikami Miwa Yasaka Takayuki Enomoto Yoichi Kobayashi Satoru Nagase Masatoshi Yokoyama Hidetaka Katabuchi Source Type: research

Transumbilical laparoendoscopic single-site surgery (TU-LESS) extraperitoneal approach for lymphadenectomy: an innovative method
CONCLUSION: TU-LESS extraperitoneal approach is an innovative method for lymphadenectomy.PMID:34132068 | DOI:10.3802/jgo.2021.32.e69 (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - June 16, 2021 Category: OBGYN Authors: Sijing Chen Yawen Wang Fan Yang Kana Wang Ying Zheng Source Type: research

Fertility-preserving treatment outcome in endometrial cancer or atypical hyperplasia patients with polycystic ovary syndrome
CONCLUSION: PCOS was associated with lower 16-week CR rate, longer treatment duration and shorter recurrence interval in patients with AEH or EEC receiving fertility-preserving treatment.PMID:34132069 | DOI:10.3802/jgo.2021.32.e70 (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - June 16, 2021 Category: OBGYN Authors: Lulu Wang Xuezhen Luo Qian Wang Qiaoying Lv Pengfei Wu Wei Liu Xiaojun Chen Source Type: research

Significance of serum CA125 level in surgically resected cervical adenocarcinoma with adverse features
This study aimed to identify the prognostic value of preoperative carbohydrate antigen 125 (CA125) levels in cervical adenocarcinoma patients with adverse pathologic features.METHODS: A total of 105 patients who underwent radical hysterectomy followed by adjuvant radiotherapy (RT) or concurrent chemoradiation therapy were included. Locoregional recurrence-free survival (LRFS), distant metastasis-free survival (DMFS), and overall survival (OS) were evaluated using the Cox proportional hazard regression model.RESULTS: Using a cutoff value of 50 U/mL, 83 and 22 patients had low- and high-CA125, respectively. Patients with hig...
Source: Journal of Gynecologic Oncology - June 16, 2021 Category: OBGYN Authors: Nalee Kim Won Park Won Kyung Cho Duk Soo Bae Byoung Gie Kim Jeong Won Lee Chel Hun Choi Tae Joong Kim Yoo Young Lee Source Type: research

Efficacy and safety of intravenous administration of high-dose selenium for preventing chemotherapy-induced peripheral neuropathy in platinum-sensitive recurrent ovarian, fallopian or primary peritoneal cancer: study protocol for a phase III, double-blind, randomized study
J Gynecol Oncol. 2021 Jun 1. doi: 10.3802/jgo.2021.32.e73. Online ahead of print.ABSTRACTBACKGROUND: The second-line chemotherapy using paclitaxel, carboplatin, and bevacizumab for treating platinum-sensitive recurrent ovarian, fallopian or primary peritoneal cancer frequently cause chemotherapy-induced peripheral neuropathy (CIPN), which is significantly associated with deterioration of quality of life. Despite the potential of some agents to prevent and treat CIPN, and there is still a lack of evidence of the effect. Although selenium has been suggested as an antioxidant candidate to prevent CIPN, there are insufficient ...
Source: Journal of Gynecologic Oncology - June 16, 2021 Category: OBGYN Authors: Soo Jin Park Ga Won Yim Haerin Paik Nara Lee Seungmee Lee Maria Lee Hee Seung Kim Source Type: research

Downregulation of LINC01508 contributes to cisplatin resistance in ovarian cancer via the regulation of the Hippo-YAP pathway
J Gynecol Oncol. 2021 Jun 10. doi: 10.3802/jgo.2021.32.e77. Online ahead of print.ABSTRACTBACKGROUND: Some long non-coding RNAs (lncRNAs) have been found to contribute to cisplatin resistance. Here, we identified a novel lncRNA that was downregulated in cisplatin-resistant to ovarian cancer (OC) cells and aimed to examine the contribution of LINC01508 to cisplatin resistance in OC cells.METHODS: Differences in the lncRNA expression profile between OV2008 and C13K cells were assessed by lncRNA expression microarray. The expression of LINC01508 in ovarian epithelial cells, four OC cells, and OC, benign ovary tumor and normal...
Source: Journal of Gynecologic Oncology - June 16, 2021 Category: OBGYN Authors: Lan Xiao Xiao Yan Shi Ze Lian Li Min Li Min Min Zhang Shi Jie Yan Zhao Lian Wei Source Type: research

Association of menopause, aging and treatment procedures with positive margins after therapeutic cervical conization for CIN 3: a retrospective study of 8,856 patients by the Japan Society of Obstetrics and Gynecology
This study aimed to determine the predictive factors for positive surgical margins in cervical intraepithelial neoplasia grade 3 (CIN 3) patients after therapeutic cervical conization and those for positive margins in patients who did not experience recurrence and did not undergo additional treatment.METHODS: In 2009 and 2013, 14,832 patients underwent cervical conization at 205 institutions in Japan. Of these, 8856 patients who underwent therapeutic conization fulfilled the inclusion criteria. Their histologic findings and clinical outcomes were evaluated based on standard statistical procedures and clinical and demograph...
Source: Journal of Gynecologic Oncology - June 16, 2021 Category: OBGYN Authors: Masae Ikeda Mikio Mikami Miwa Yasaka Takayuki Enomoto Yoichi Kobayashi Satoru Nagase Masatoshi Yokoyama Hidetaka Katabuchi Source Type: research

Transumbilical laparoendoscopic single-site surgery (TU-LESS) extraperitoneal approach for lymphadenectomy: an innovative method
CONCLUSION: TU-LESS extraperitoneal approach is an innovative method for lymphadenectomy.PMID:34132068 | DOI:10.3802/jgo.2021.32.e69 (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - June 16, 2021 Category: OBGYN Authors: Sijing Chen Yawen Wang Fan Yang Kana Wang Ying Zheng Source Type: research

Fertility-preserving treatment outcome in endometrial cancer or atypical hyperplasia patients with polycystic ovary syndrome
CONCLUSION: PCOS was associated with lower 16-week CR rate, longer treatment duration and shorter recurrence interval in patients with AEH or EEC receiving fertility-preserving treatment.PMID:34132069 | DOI:10.3802/jgo.2021.32.e70 (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - June 16, 2021 Category: OBGYN Authors: Lulu Wang Xuezhen Luo Qian Wang Qiaoying Lv Pengfei Wu Wei Liu Xiaojun Chen Source Type: research

Significance of serum CA125 level in surgically resected cervical adenocarcinoma with adverse features
This study aimed to identify the prognostic value of preoperative carbohydrate antigen 125 (CA125) levels in cervical adenocarcinoma patients with adverse pathologic features.METHODS: A total of 105 patients who underwent radical hysterectomy followed by adjuvant radiotherapy (RT) or concurrent chemoradiation therapy were included. Locoregional recurrence-free survival (LRFS), distant metastasis-free survival (DMFS), and overall survival (OS) were evaluated using the Cox proportional hazard regression model.RESULTS: Using a cutoff value of 50 U/mL, 83 and 22 patients had low- and high-CA125, respectively. Patients with hig...
Source: Journal of Gynecologic Oncology - June 16, 2021 Category: OBGYN Authors: Nalee Kim Won Park Won Kyung Cho Duk Soo Bae Byoung Gie Kim Jeong Won Lee Chel Hun Choi Tae Joong Kim Yoo Young Lee Source Type: research

Efficacy and safety of intravenous administration of high-dose selenium for preventing chemotherapy-induced peripheral neuropathy in platinum-sensitive recurrent ovarian, fallopian or primary peritoneal cancer: study protocol for a phase III, double-blind, randomized study
J Gynecol Oncol. 2021 Jun 1. doi: 10.3802/jgo.2021.32.e73. Online ahead of print.ABSTRACTBACKGROUND: The second-line chemotherapy using paclitaxel, carboplatin, and bevacizumab for treating platinum-sensitive recurrent ovarian, fallopian or primary peritoneal cancer frequently cause chemotherapy-induced peripheral neuropathy (CIPN), which is significantly associated with deterioration of quality of life. Despite the potential of some agents to prevent and treat CIPN, and there is still a lack of evidence of the effect. Although selenium has been suggested as an antioxidant candidate to prevent CIPN, there are insufficient ...
Source: Journal of Gynecologic Oncology - June 16, 2021 Category: OBGYN Authors: Soo Jin Park Ga Won Yim Haerin Paik Nara Lee Seungmee Lee Maria Lee Hee Seung Kim Source Type: research

Downregulation of LINC01508 contributes to cisplatin resistance in ovarian cancer via the regulation of the Hippo-YAP pathway
J Gynecol Oncol. 2021 Jun 10. doi: 10.3802/jgo.2021.32.e77. Online ahead of print.ABSTRACTBACKGROUND: Some long non-coding RNAs (lncRNAs) have been found to contribute to cisplatin resistance. Here, we identified a novel lncRNA that was downregulated in cisplatin-resistant to ovarian cancer (OC) cells and aimed to examine the contribution of LINC01508 to cisplatin resistance in OC cells.METHODS: Differences in the lncRNA expression profile between OV2008 and C13K cells were assessed by lncRNA expression microarray. The expression of LINC01508 in ovarian epithelial cells, four OC cells, and OC, benign ovary tumor and normal...
Source: Journal of Gynecologic Oncology - June 16, 2021 Category: OBGYN Authors: Lan Xiao Xiao Yan Shi Ze Lian Li Min Li Min Min Zhang Shi Jie Yan Zhao Lian Wei Source Type: research

Association of menopause, aging and treatment procedures with positive margins after therapeutic cervical conization for CIN 3: a retrospective study of 8,856 patients by the Japan Society of Obstetrics and Gynecology
This study aimed to determine the predictive factors for positive surgical margins in cervical intraepithelial neoplasia grade 3 (CIN 3) patients after therapeutic cervical conization and those for positive margins in patients who did not experience recurrence and did not undergo additional treatment.METHODS: In 2009 and 2013, 14,832 patients underwent cervical conization at 205 institutions in Japan. Of these, 8856 patients who underwent therapeutic conization fulfilled the inclusion criteria. Their histologic findings and clinical outcomes were evaluated based on standard statistical procedures and clinical and demograph...
Source: Journal of Gynecologic Oncology - June 16, 2021 Category: OBGYN Authors: Masae Ikeda Mikio Mikami Miwa Yasaka Takayuki Enomoto Yoichi Kobayashi Satoru Nagase Masatoshi Yokoyama Hidetaka Katabuchi Source Type: research

Transumbilical laparoendoscopic single-site surgery (TU-LESS) extraperitoneal approach for lymphadenectomy: an innovative method
CONCLUSION: TU-LESS extraperitoneal approach is an innovative method for lymphadenectomy.PMID:34132068 | DOI:10.3802/jgo.2021.32.e69 (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - June 16, 2021 Category: OBGYN Authors: Sijing Chen Yawen Wang Fan Yang Kana Wang Ying Zheng Source Type: research

Fertility-preserving treatment outcome in endometrial cancer or atypical hyperplasia patients with polycystic ovary syndrome
CONCLUSION: PCOS was associated with lower 16-week CR rate, longer treatment duration and shorter recurrence interval in patients with AEH or EEC receiving fertility-preserving treatment.PMID:34132069 | DOI:10.3802/jgo.2021.32.e70 (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - June 16, 2021 Category: OBGYN Authors: Lulu Wang Xuezhen Luo Qian Wang Qiaoying Lv Pengfei Wu Wei Liu Xiaojun Chen Source Type: research

Significance of serum CA125 level in surgically resected cervical adenocarcinoma with adverse features
This study aimed to identify the prognostic value of preoperative carbohydrate antigen 125 (CA125) levels in cervical adenocarcinoma patients with adverse pathologic features.METHODS: A total of 105 patients who underwent radical hysterectomy followed by adjuvant radiotherapy (RT) or concurrent chemoradiation therapy were included. Locoregional recurrence-free survival (LRFS), distant metastasis-free survival (DMFS), and overall survival (OS) were evaluated using the Cox proportional hazard regression model.RESULTS: Using a cutoff value of 50 U/mL, 83 and 22 patients had low- and high-CA125, respectively. Patients with hig...
Source: Journal of Gynecologic Oncology - June 16, 2021 Category: OBGYN Authors: Nalee Kim Won Park Won Kyung Cho Duk Soo Bae Byoung Gie Kim Jeong Won Lee Chel Hun Choi Tae Joong Kim Yoo Young Lee Source Type: research

Efficacy and safety of intravenous administration of high-dose selenium for preventing chemotherapy-induced peripheral neuropathy in platinum-sensitive recurrent ovarian, fallopian or primary peritoneal cancer: study protocol for a phase III, double-blind, randomized study
J Gynecol Oncol. 2021 Jun 1. doi: 10.3802/jgo.2021.32.e73. Online ahead of print.ABSTRACTBACKGROUND: The second-line chemotherapy using paclitaxel, carboplatin, and bevacizumab for treating platinum-sensitive recurrent ovarian, fallopian or primary peritoneal cancer frequently cause chemotherapy-induced peripheral neuropathy (CIPN), which is significantly associated with deterioration of quality of life. Despite the potential of some agents to prevent and treat CIPN, and there is still a lack of evidence of the effect. Although selenium has been suggested as an antioxidant candidate to prevent CIPN, there are insufficient ...
Source: Journal of Gynecologic Oncology - June 16, 2021 Category: OBGYN Authors: Soo Jin Park Ga Won Yim Haerin Paik Nara Lee Seungmee Lee Maria Lee Hee Seung Kim Source Type: research

Downregulation of LINC01508 contributes to cisplatin resistance in ovarian cancer via the regulation of the Hippo-YAP pathway
J Gynecol Oncol. 2021 Jun 10. doi: 10.3802/jgo.2021.32.e77. Online ahead of print.ABSTRACTBACKGROUND: Some long non-coding RNAs (lncRNAs) have been found to contribute to cisplatin resistance. Here, we identified a novel lncRNA that was downregulated in cisplatin-resistant to ovarian cancer (OC) cells and aimed to examine the contribution of LINC01508 to cisplatin resistance in OC cells.METHODS: Differences in the lncRNA expression profile between OV2008 and C13K cells were assessed by lncRNA expression microarray. The expression of LINC01508 in ovarian epithelial cells, four OC cells, and OC, benign ovary tumor and normal...
Source: Journal of Gynecologic Oncology - June 16, 2021 Category: OBGYN Authors: Lan Xiao Xiao Yan Shi Ze Lian Li Min Li Min Min Zhang Shi Jie Yan Zhao Lian Wei Source Type: research

Association of menopause, aging and treatment procedures with positive margins after therapeutic cervical conization for CIN 3: a retrospective study of 8,856 patients by the Japan Society of Obstetrics and Gynecology
This study aimed to determine the predictive factors for positive surgical margins in cervical intraepithelial neoplasia grade 3 (CIN 3) patients after therapeutic cervical conization and those for positive margins in patients who did not experience recurrence and did not undergo additional treatment.METHODS: In 2009 and 2013, 14,832 patients underwent cervical conization at 205 institutions in Japan. Of these, 8856 patients who underwent therapeutic conization fulfilled the inclusion criteria. Their histologic findings and clinical outcomes were evaluated based on standard statistical procedures and clinical and demograph...
Source: Journal of Gynecologic Oncology - June 16, 2021 Category: OBGYN Authors: Masae Ikeda Mikio Mikami Miwa Yasaka Takayuki Enomoto Yoichi Kobayashi Satoru Nagase Masatoshi Yokoyama Hidetaka Katabuchi Source Type: research

Transumbilical laparoendoscopic single-site surgery (TU-LESS) extraperitoneal approach for lymphadenectomy: an innovative method
CONCLUSION: TU-LESS extraperitoneal approach is an innovative method for lymphadenectomy.PMID:34132068 | DOI:10.3802/jgo.2021.32.e69 (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - June 16, 2021 Category: OBGYN Authors: Sijing Chen Yawen Wang Fan Yang Kana Wang Ying Zheng Source Type: research

Fertility-preserving treatment outcome in endometrial cancer or atypical hyperplasia patients with polycystic ovary syndrome
CONCLUSION: PCOS was associated with lower 16-week CR rate, longer treatment duration and shorter recurrence interval in patients with AEH or EEC receiving fertility-preserving treatment.PMID:34132069 | DOI:10.3802/jgo.2021.32.e70 (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - June 16, 2021 Category: OBGYN Authors: Lulu Wang Xuezhen Luo Qian Wang Qiaoying Lv Pengfei Wu Wei Liu Xiaojun Chen Source Type: research

Significance of serum CA125 level in surgically resected cervical adenocarcinoma with adverse features
This study aimed to identify the prognostic value of preoperative carbohydrate antigen 125 (CA125) levels in cervical adenocarcinoma patients with adverse pathologic features.METHODS: A total of 105 patients who underwent radical hysterectomy followed by adjuvant radiotherapy (RT) or concurrent chemoradiation therapy were included. Locoregional recurrence-free survival (LRFS), distant metastasis-free survival (DMFS), and overall survival (OS) were evaluated using the Cox proportional hazard regression model.RESULTS: Using a cutoff value of 50 U/mL, 83 and 22 patients had low- and high-CA125, respectively. Patients with hig...
Source: Journal of Gynecologic Oncology - June 16, 2021 Category: OBGYN Authors: Nalee Kim Won Park Won Kyung Cho Duk Soo Bae Byoung Gie Kim Jeong Won Lee Chel Hun Choi Tae Joong Kim Yoo Young Lee Source Type: research

Efficacy and safety of intravenous administration of high-dose selenium for preventing chemotherapy-induced peripheral neuropathy in platinum-sensitive recurrent ovarian, fallopian or primary peritoneal cancer: study protocol for a phase III, double-blind, randomized study
J Gynecol Oncol. 2021 Jun 1. doi: 10.3802/jgo.2021.32.e73. Online ahead of print.ABSTRACTBACKGROUND: The second-line chemotherapy using paclitaxel, carboplatin, and bevacizumab for treating platinum-sensitive recurrent ovarian, fallopian or primary peritoneal cancer frequently cause chemotherapy-induced peripheral neuropathy (CIPN), which is significantly associated with deterioration of quality of life. Despite the potential of some agents to prevent and treat CIPN, and there is still a lack of evidence of the effect. Although selenium has been suggested as an antioxidant candidate to prevent CIPN, there are insufficient ...
Source: Journal of Gynecologic Oncology - June 16, 2021 Category: OBGYN Authors: Soo Jin Park Ga Won Yim Haerin Paik Nara Lee Seungmee Lee Maria Lee Hee Seung Kim Source Type: research

Downregulation of LINC01508 contributes to cisplatin resistance in ovarian cancer via the regulation of the Hippo-YAP pathway
J Gynecol Oncol. 2021 Jun 10. doi: 10.3802/jgo.2021.32.e77. Online ahead of print.ABSTRACTBACKGROUND: Some long non-coding RNAs (lncRNAs) have been found to contribute to cisplatin resistance. Here, we identified a novel lncRNA that was downregulated in cisplatin-resistant to ovarian cancer (OC) cells and aimed to examine the contribution of LINC01508 to cisplatin resistance in OC cells.METHODS: Differences in the lncRNA expression profile between OV2008 and C13K cells were assessed by lncRNA expression microarray. The expression of LINC01508 in ovarian epithelial cells, four OC cells, and OC, benign ovary tumor and normal...
Source: Journal of Gynecologic Oncology - June 16, 2021 Category: OBGYN Authors: Lan Xiao Xiao Yan Shi Ze Lian Li Min Li Min Min Zhang Shi Jie Yan Zhao Lian Wei Source Type: research

Association of menopause, aging and treatment procedures with positive margins after therapeutic cervical conization for CIN 3: a retrospective study of 8,856 patients by the Japan Society of Obstetrics and Gynecology
This study aimed to determine the predictive factors for positive surgical margins in cervical intraepithelial neoplasia grade 3 (CIN 3) patients after therapeutic cervical conization and those for positive margins in patients who did not experience recurrence and did not undergo additional treatment.METHODS: In 2009 and 2013, 14,832 patients underwent cervical conization at 205 institutions in Japan. Of these, 8856 patients who underwent therapeutic conization fulfilled the inclusion criteria. Their histologic findings and clinical outcomes were evaluated based on standard statistical procedures and clinical and demograph...
Source: Journal of Gynecologic Oncology - June 16, 2021 Category: OBGYN Authors: Masae Ikeda Mikio Mikami Miwa Yasaka Takayuki Enomoto Yoichi Kobayashi Satoru Nagase Masatoshi Yokoyama Hidetaka Katabuchi Source Type: research

Transumbilical laparoendoscopic single-site surgery (TU-LESS) extraperitoneal approach for lymphadenectomy: an innovative method
CONCLUSION: TU-LESS extraperitoneal approach is an innovative method for lymphadenectomy.PMID:34132068 | DOI:10.3802/jgo.2021.32.e69 (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - June 16, 2021 Category: OBGYN Authors: Sijing Chen Yawen Wang Fan Yang Kana Wang Ying Zheng Source Type: research

Fertility-preserving treatment outcome in endometrial cancer or atypical hyperplasia patients with polycystic ovary syndrome
CONCLUSION: PCOS was associated with lower 16-week CR rate, longer treatment duration and shorter recurrence interval in patients with AEH or EEC receiving fertility-preserving treatment.PMID:34132069 | DOI:10.3802/jgo.2021.32.e70 (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - June 16, 2021 Category: OBGYN Authors: Lulu Wang Xuezhen Luo Qian Wang Qiaoying Lv Pengfei Wu Wei Liu Xiaojun Chen Source Type: research

Significance of serum CA125 level in surgically resected cervical adenocarcinoma with adverse features
This study aimed to identify the prognostic value of preoperative carbohydrate antigen 125 (CA125) levels in cervical adenocarcinoma patients with adverse pathologic features.METHODS: A total of 105 patients who underwent radical hysterectomy followed by adjuvant radiotherapy (RT) or concurrent chemoradiation therapy were included. Locoregional recurrence-free survival (LRFS), distant metastasis-free survival (DMFS), and overall survival (OS) were evaluated using the Cox proportional hazard regression model.RESULTS: Using a cutoff value of 50 U/mL, 83 and 22 patients had low- and high-CA125, respectively. Patients with hig...
Source: Journal of Gynecologic Oncology - June 16, 2021 Category: OBGYN Authors: Nalee Kim Won Park Won Kyung Cho Duk Soo Bae Byoung Gie Kim Jeong Won Lee Chel Hun Choi Tae Joong Kim Yoo Young Lee Source Type: research

Efficacy and safety of intravenous administration of high-dose selenium for preventing chemotherapy-induced peripheral neuropathy in platinum-sensitive recurrent ovarian, fallopian or primary peritoneal cancer: study protocol for a phase III, double-blind, randomized study
J Gynecol Oncol. 2021 Jun 1. doi: 10.3802/jgo.2021.32.e73. Online ahead of print.ABSTRACTBACKGROUND: The second-line chemotherapy using paclitaxel, carboplatin, and bevacizumab for treating platinum-sensitive recurrent ovarian, fallopian or primary peritoneal cancer frequently cause chemotherapy-induced peripheral neuropathy (CIPN), which is significantly associated with deterioration of quality of life. Despite the potential of some agents to prevent and treat CIPN, and there is still a lack of evidence of the effect. Although selenium has been suggested as an antioxidant candidate to prevent CIPN, there are insufficient ...
Source: Journal of Gynecologic Oncology - June 16, 2021 Category: OBGYN Authors: Soo Jin Park Ga Won Yim Haerin Paik Nara Lee Seungmee Lee Maria Lee Hee Seung Kim Source Type: research

Downregulation of LINC01508 contributes to cisplatin resistance in ovarian cancer via the regulation of the Hippo-YAP pathway
J Gynecol Oncol. 2021 Jun 10. doi: 10.3802/jgo.2021.32.e77. Online ahead of print.ABSTRACTBACKGROUND: Some long non-coding RNAs (lncRNAs) have been found to contribute to cisplatin resistance. Here, we identified a novel lncRNA that was downregulated in cisplatin-resistant to ovarian cancer (OC) cells and aimed to examine the contribution of LINC01508 to cisplatin resistance in OC cells.METHODS: Differences in the lncRNA expression profile between OV2008 and C13K cells were assessed by lncRNA expression microarray. The expression of LINC01508 in ovarian epithelial cells, four OC cells, and OC, benign ovary tumor and normal...
Source: Journal of Gynecologic Oncology - June 16, 2021 Category: OBGYN Authors: Lan Xiao Xiao Yan Shi Ze Lian Li Min Li Min Min Zhang Shi Jie Yan Zhao Lian Wei Source Type: research

Association of menopause, aging and treatment procedures with positive margins after therapeutic cervical conization for CIN 3: a retrospective study of 8,856 patients by the Japan Society of Obstetrics and Gynecology
This study aimed to determine the predictive factors for positive surgical margins in cervical intraepithelial neoplasia grade 3 (CIN 3) patients after therapeutic cervical conization and those for positive margins in patients who did not experience recurrence and did not undergo additional treatment.METHODS: In 2009 and 2013, 14,832 patients underwent cervical conization at 205 institutions in Japan. Of these, 8856 patients who underwent therapeutic conization fulfilled the inclusion criteria. Their histologic findings and clinical outcomes were evaluated based on standard statistical procedures and clinical and demograph...
Source: Journal of Gynecologic Oncology - June 16, 2021 Category: OBGYN Authors: Masae Ikeda Mikio Mikami Miwa Yasaka Takayuki Enomoto Yoichi Kobayashi Satoru Nagase Masatoshi Yokoyama Hidetaka Katabuchi Source Type: research

Transumbilical laparoendoscopic single-site surgery (TU-LESS) extraperitoneal approach for lymphadenectomy: an innovative method
CONCLUSION: TU-LESS extraperitoneal approach is an innovative method for lymphadenectomy.PMID:34132068 | DOI:10.3802/jgo.2021.32.e69 (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - June 16, 2021 Category: OBGYN Authors: Sijing Chen Yawen Wang Fan Yang Kana Wang Ying Zheng Source Type: research

Fertility-preserving treatment outcome in endometrial cancer or atypical hyperplasia patients with polycystic ovary syndrome
CONCLUSION: PCOS was associated with lower 16-week CR rate, longer treatment duration and shorter recurrence interval in patients with AEH or EEC receiving fertility-preserving treatment.PMID:34132069 | DOI:10.3802/jgo.2021.32.e70 (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - June 16, 2021 Category: OBGYN Authors: Lulu Wang Xuezhen Luo Qian Wang Qiaoying Lv Pengfei Wu Wei Liu Xiaojun Chen Source Type: research

Significance of serum CA125 level in surgically resected cervical adenocarcinoma with adverse features
This study aimed to identify the prognostic value of preoperative carbohydrate antigen 125 (CA125) levels in cervical adenocarcinoma patients with adverse pathologic features.METHODS: A total of 105 patients who underwent radical hysterectomy followed by adjuvant radiotherapy (RT) or concurrent chemoradiation therapy were included. Locoregional recurrence-free survival (LRFS), distant metastasis-free survival (DMFS), and overall survival (OS) were evaluated using the Cox proportional hazard regression model.RESULTS: Using a cutoff value of 50 U/mL, 83 and 22 patients had low- and high-CA125, respectively. Patients with hig...
Source: Journal of Gynecologic Oncology - June 16, 2021 Category: OBGYN Authors: Nalee Kim Won Park Won Kyung Cho Duk Soo Bae Byoung Gie Kim Jeong Won Lee Chel Hun Choi Tae Joong Kim Yoo Young Lee Source Type: research

Efficacy and safety of intravenous administration of high-dose selenium for preventing chemotherapy-induced peripheral neuropathy in platinum-sensitive recurrent ovarian, fallopian or primary peritoneal cancer: study protocol for a phase III, double-blind, randomized study
J Gynecol Oncol. 2021 Jun 1. doi: 10.3802/jgo.2021.32.e73. Online ahead of print.ABSTRACTBACKGROUND: The second-line chemotherapy using paclitaxel, carboplatin, and bevacizumab for treating platinum-sensitive recurrent ovarian, fallopian or primary peritoneal cancer frequently cause chemotherapy-induced peripheral neuropathy (CIPN), which is significantly associated with deterioration of quality of life. Despite the potential of some agents to prevent and treat CIPN, and there is still a lack of evidence of the effect. Although selenium has been suggested as an antioxidant candidate to prevent CIPN, there are insufficient ...
Source: Journal of Gynecologic Oncology - June 16, 2021 Category: OBGYN Authors: Soo Jin Park Ga Won Yim Haerin Paik Nara Lee Seungmee Lee Maria Lee Hee Seung Kim Source Type: research

Downregulation of LINC01508 contributes to cisplatin resistance in ovarian cancer via the regulation of the Hippo-YAP pathway
J Gynecol Oncol. 2021 Jun 10. doi: 10.3802/jgo.2021.32.e77. Online ahead of print.ABSTRACTBACKGROUND: Some long non-coding RNAs (lncRNAs) have been found to contribute to cisplatin resistance. Here, we identified a novel lncRNA that was downregulated in cisplatin-resistant to ovarian cancer (OC) cells and aimed to examine the contribution of LINC01508 to cisplatin resistance in OC cells.METHODS: Differences in the lncRNA expression profile between OV2008 and C13K cells were assessed by lncRNA expression microarray. The expression of LINC01508 in ovarian epithelial cells, four OC cells, and OC, benign ovary tumor and normal...
Source: Journal of Gynecologic Oncology - June 16, 2021 Category: OBGYN Authors: Lan Xiao Xiao Yan Shi Ze Lian Li Min Li Min Min Zhang Shi Jie Yan Zhao Lian Wei Source Type: research

Association of menopause, aging and treatment procedures with positive margins after therapeutic cervical conization for CIN 3: a retrospective study of 8,856 patients by the Japan Society of Obstetrics and Gynecology
This study aimed to determine the predictive factors for positive surgical margins in cervical intraepithelial neoplasia grade 3 (CIN 3) patients after therapeutic cervical conization and those for positive margins in patients who did not experience recurrence and did not undergo additional treatment.METHODS: In 2009 and 2013, 14,832 patients underwent cervical conization at 205 institutions in Japan. Of these, 8856 patients who underwent therapeutic conization fulfilled the inclusion criteria. Their histologic findings and clinical outcomes were evaluated based on standard statistical procedures and clinical and demograph...
Source: Journal of Gynecologic Oncology - June 16, 2021 Category: OBGYN Authors: Masae Ikeda Mikio Mikami Miwa Yasaka Takayuki Enomoto Yoichi Kobayashi Satoru Nagase Masatoshi Yokoyama Hidetaka Katabuchi Source Type: research

Transumbilical laparoendoscopic single-site surgery (TU-LESS) extraperitoneal approach for lymphadenectomy: an innovative method
CONCLUSION: TU-LESS extraperitoneal approach is an innovative method for lymphadenectomy.PMID:34132068 | DOI:10.3802/jgo.2021.32.e69 (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - June 16, 2021 Category: OBGYN Authors: Sijing Chen Yawen Wang Fan Yang Kana Wang Ying Zheng Source Type: research

Fertility-preserving treatment outcome in endometrial cancer or atypical hyperplasia patients with polycystic ovary syndrome
CONCLUSION: PCOS was associated with lower 16-week CR rate, longer treatment duration and shorter recurrence interval in patients with AEH or EEC receiving fertility-preserving treatment.PMID:34132069 | DOI:10.3802/jgo.2021.32.e70 (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - June 16, 2021 Category: OBGYN Authors: Lulu Wang Xuezhen Luo Qian Wang Qiaoying Lv Pengfei Wu Wei Liu Xiaojun Chen Source Type: research

Significance of serum CA125 level in surgically resected cervical adenocarcinoma with adverse features
This study aimed to identify the prognostic value of preoperative carbohydrate antigen 125 (CA125) levels in cervical adenocarcinoma patients with adverse pathologic features.METHODS: A total of 105 patients who underwent radical hysterectomy followed by adjuvant radiotherapy (RT) or concurrent chemoradiation therapy were included. Locoregional recurrence-free survival (LRFS), distant metastasis-free survival (DMFS), and overall survival (OS) were evaluated using the Cox proportional hazard regression model.RESULTS: Using a cutoff value of 50 U/mL, 83 and 22 patients had low- and high-CA125, respectively. Patients with hig...
Source: Journal of Gynecologic Oncology - June 16, 2021 Category: OBGYN Authors: Nalee Kim Won Park Won Kyung Cho Duk Soo Bae Byoung Gie Kim Jeong Won Lee Chel Hun Choi Tae Joong Kim Yoo Young Lee Source Type: research

Efficacy and safety of intravenous administration of high-dose selenium for preventing chemotherapy-induced peripheral neuropathy in platinum-sensitive recurrent ovarian, fallopian or primary peritoneal cancer: study protocol for a phase III, double-blind, randomized study
J Gynecol Oncol. 2021 Jun 1. doi: 10.3802/jgo.2021.32.e73. Online ahead of print.ABSTRACTBACKGROUND: The second-line chemotherapy using paclitaxel, carboplatin, and bevacizumab for treating platinum-sensitive recurrent ovarian, fallopian or primary peritoneal cancer frequently cause chemotherapy-induced peripheral neuropathy (CIPN), which is significantly associated with deterioration of quality of life. Despite the potential of some agents to prevent and treat CIPN, and there is still a lack of evidence of the effect. Although selenium has been suggested as an antioxidant candidate to prevent CIPN, there are insufficient ...
Source: Journal of Gynecologic Oncology - June 16, 2021 Category: OBGYN Authors: Soo Jin Park Ga Won Yim Haerin Paik Nara Lee Seungmee Lee Maria Lee Hee Seung Kim Source Type: research

Downregulation of LINC01508 contributes to cisplatin resistance in ovarian cancer via the regulation of the Hippo-YAP pathway
J Gynecol Oncol. 2021 Jun 10. doi: 10.3802/jgo.2021.32.e77. Online ahead of print.ABSTRACTBACKGROUND: Some long non-coding RNAs (lncRNAs) have been found to contribute to cisplatin resistance. Here, we identified a novel lncRNA that was downregulated in cisplatin-resistant to ovarian cancer (OC) cells and aimed to examine the contribution of LINC01508 to cisplatin resistance in OC cells.METHODS: Differences in the lncRNA expression profile between OV2008 and C13K cells were assessed by lncRNA expression microarray. The expression of LINC01508 in ovarian epithelial cells, four OC cells, and OC, benign ovary tumor and normal...
Source: Journal of Gynecologic Oncology - June 16, 2021 Category: OBGYN Authors: Lan Xiao Xiao Yan Shi Ze Lian Li Min Li Min Min Zhang Shi Jie Yan Zhao Lian Wei Source Type: research

Association of menopause, aging and treatment procedures with positive margins after therapeutic cervical conization for CIN 3: a retrospective study of 8,856 patients by the Japan Society of Obstetrics and Gynecology
This study aimed to determine the predictive factors for positive surgical margins in cervical intraepithelial neoplasia grade 3 (CIN 3) patients after therapeutic cervical conization and those for positive margins in patients who did not experience recurrence and did not undergo additional treatment.METHODS: In 2009 and 2013, 14,832 patients underwent cervical conization at 205 institutions in Japan. Of these, 8856 patients who underwent therapeutic conization fulfilled the inclusion criteria. Their histologic findings and clinical outcomes were evaluated based on standard statistical procedures and clinical and demograph...
Source: Journal of Gynecologic Oncology - June 16, 2021 Category: OBGYN Authors: Masae Ikeda Mikio Mikami Miwa Yasaka Takayuki Enomoto Yoichi Kobayashi Satoru Nagase Masatoshi Yokoyama Hidetaka Katabuchi Source Type: research

Transumbilical laparoendoscopic single-site surgery (TU-LESS) extraperitoneal approach for lymphadenectomy: an innovative method
CONCLUSION: TU-LESS extraperitoneal approach is an innovative method for lymphadenectomy.PMID:34132068 | DOI:10.3802/jgo.2021.32.e69 (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - June 16, 2021 Category: OBGYN Authors: Sijing Chen Yawen Wang Fan Yang Kana Wang Ying Zheng Source Type: research

Fertility-preserving treatment outcome in endometrial cancer or atypical hyperplasia patients with polycystic ovary syndrome
CONCLUSION: PCOS was associated with lower 16-week CR rate, longer treatment duration and shorter recurrence interval in patients with AEH or EEC receiving fertility-preserving treatment.PMID:34132069 | DOI:10.3802/jgo.2021.32.e70 (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - June 16, 2021 Category: OBGYN Authors: Lulu Wang Xuezhen Luo Qian Wang Qiaoying Lv Pengfei Wu Wei Liu Xiaojun Chen Source Type: research

Significance of serum CA125 level in surgically resected cervical adenocarcinoma with adverse features
This study aimed to identify the prognostic value of preoperative carbohydrate antigen 125 (CA125) levels in cervical adenocarcinoma patients with adverse pathologic features.METHODS: A total of 105 patients who underwent radical hysterectomy followed by adjuvant radiotherapy (RT) or concurrent chemoradiation therapy were included. Locoregional recurrence-free survival (LRFS), distant metastasis-free survival (DMFS), and overall survival (OS) were evaluated using the Cox proportional hazard regression model.RESULTS: Using a cutoff value of 50 U/mL, 83 and 22 patients had low- and high-CA125, respectively. Patients with hig...
Source: Journal of Gynecologic Oncology - June 16, 2021 Category: OBGYN Authors: Nalee Kim Won Park Won Kyung Cho Duk Soo Bae Byoung Gie Kim Jeong Won Lee Chel Hun Choi Tae Joong Kim Yoo Young Lee Source Type: research

Efficacy and safety of intravenous administration of high-dose selenium for preventing chemotherapy-induced peripheral neuropathy in platinum-sensitive recurrent ovarian, fallopian or primary peritoneal cancer: study protocol for a phase III, double-blind, randomized study
J Gynecol Oncol. 2021 Jun 1. doi: 10.3802/jgo.2021.32.e73. Online ahead of print.ABSTRACTBACKGROUND: The second-line chemotherapy using paclitaxel, carboplatin, and bevacizumab for treating platinum-sensitive recurrent ovarian, fallopian or primary peritoneal cancer frequently cause chemotherapy-induced peripheral neuropathy (CIPN), which is significantly associated with deterioration of quality of life. Despite the potential of some agents to prevent and treat CIPN, and there is still a lack of evidence of the effect. Although selenium has been suggested as an antioxidant candidate to prevent CIPN, there are insufficient ...
Source: Journal of Gynecologic Oncology - June 16, 2021 Category: OBGYN Authors: Soo Jin Park Ga Won Yim Haerin Paik Nara Lee Seungmee Lee Maria Lee Hee Seung Kim Source Type: research

Downregulation of LINC01508 contributes to cisplatin resistance in ovarian cancer via the regulation of the Hippo-YAP pathway
J Gynecol Oncol. 2021 Jun 10. doi: 10.3802/jgo.2021.32.e77. Online ahead of print.ABSTRACTBACKGROUND: Some long non-coding RNAs (lncRNAs) have been found to contribute to cisplatin resistance. Here, we identified a novel lncRNA that was downregulated in cisplatin-resistant to ovarian cancer (OC) cells and aimed to examine the contribution of LINC01508 to cisplatin resistance in OC cells.METHODS: Differences in the lncRNA expression profile between OV2008 and C13K cells were assessed by lncRNA expression microarray. The expression of LINC01508 in ovarian epithelial cells, four OC cells, and OC, benign ovary tumor and normal...
Source: Journal of Gynecologic Oncology - June 16, 2021 Category: OBGYN Authors: Lan Xiao Xiao Yan Shi Ze Lian Li Min Li Min Min Zhang Shi Jie Yan Zhao Lian Wei Source Type: research

Association of menopause, aging and treatment procedures with positive margins after therapeutic cervical conization for CIN 3: a retrospective study of 8,856 patients by the Japan Society of Obstetrics and Gynecology
This study aimed to determine the predictive factors for positive surgical margins in cervical intraepithelial neoplasia grade 3 (CIN 3) patients after therapeutic cervical conization and those for positive margins in patients who did not experience recurrence and did not undergo additional treatment.METHODS: In 2009 and 2013, 14,832 patients underwent cervical conization at 205 institutions in Japan. Of these, 8856 patients who underwent therapeutic conization fulfilled the inclusion criteria. Their histologic findings and clinical outcomes were evaluated based on standard statistical procedures and clinical and demograph...
Source: Journal of Gynecologic Oncology - June 16, 2021 Category: OBGYN Authors: Masae Ikeda Mikio Mikami Miwa Yasaka Takayuki Enomoto Yoichi Kobayashi Satoru Nagase Masatoshi Yokoyama Hidetaka Katabuchi Source Type: research

Transumbilical laparoendoscopic single-site surgery (TU-LESS) extraperitoneal approach for lymphadenectomy: an innovative method
CONCLUSION: TU-LESS extraperitoneal approach is an innovative method for lymphadenectomy.PMID:34132068 | DOI:10.3802/jgo.2021.32.e69 (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - June 16, 2021 Category: OBGYN Authors: Sijing Chen Yawen Wang Fan Yang Kana Wang Ying Zheng Source Type: research