Risk factors for early death among ovarian cancer patients: a nationwide cohort study.
CONCLUSIONS: Despite several admissions to hospital, the ovarian cancer diagnosis is delayed for a subgroup of patients, who end up dying early, probably due to physical deterioration in the ineffective waiting time. Up to 90% of high-risk patients might be identified significantly earlier to improve the prognosis. The admittance of the patients having risk symptoms should include fast track investigation for ovarian cancer. PMID: 32026656 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - February 8, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

The 16-year experience in treating low-risk gestational trophoblastic neoplasia patients with failed primary methotrexate chemotherapy.
CONCLUSION: Based on the good therapeutic effect and tolerable toxicity, we recommend Act-D salvage therapy for all patients with low-risk GTN who fail primary MTX chemotherapy. The higher serum hCG levels before Act-D salvage therapy may be associated with resistance to this treatment. PMID: 32026657 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - February 8, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Comparing efficacy of high-dose rate brachytherapy versus helical tomotherapy in the treatment of cervical cancer.
CONCLUSIONS: HT boost treatment showed comparable disease outcomes with those observed with conventional BT in patients with advanced cervical cancer. HT could be a complementary boost protocol as a single modality or hybrid with BT in selected patients. Further studies with longer follow-up periods are warranted to confirm long-term outcomes. PMID: 32026658 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - February 8, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

A retrospective study for investigating the relationship between old and new staging systems with prognosis in ovarian cancer using gynecologic cancer registry of Japan Society of Obstetrics and Gynecology (JSOG): disparity between serous carcinoma and clear cell carcinoma.
Authors: Yamagami W, Nagase S, Takahashi F, Ino K, Hachisuga T, Mikami M, Enomoto T, Katabuchi H, Aoki D Abstract OBJECTIVE: International Federation of Gynecology and Obstetrics (FIGO) staging for ovarian, fallopian tube, and peritoneal cancers was revised in 2014. The aim of this study is to clarify whether the revised FIGO2014 staging reflects the prognosis of patients with ovarian cancer by histological type in Japan. METHODS: We extracted 9,747 patients who were diagnosed with ovarian cancer since 2004 until 2008 and who could be classified into appropriate stages from the Gynecologic Cancer Registry of Ja...
Source: Journal of Gynecologic Oncology - February 8, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

SURF4 maintains stem-like properties via BIRC3 in ovarian cancer cells.
CONCLUSION: Our findings suggest that SURF4 possesses the ability to maintain stemness of OCSCs via BIRC3, and may serve as a potential target in stem cell-targeted therapy for ovarian cancer. PMID: 32026660 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - February 8, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

The impact of systematic retroperitoneal lymphadenectomy on long-term oncologic outcome of women with advanced ovarian clear-cell carcinoma.
Authors: Kajiyama H, Suzuki S, Yoshikawa N, Tamauchi S, Shibata K, Kikkawa F Abstract OBJECTIVE: The impact of systematic retroperitoneal lymphadenectomy (SRL) remains controversial in patients with advanced ovarian clear-cell carcinoma (CCC) who are optimally debulked. METHODS: Between 1986 and 2017, a total of 3,227 women with epithelial ovarian carcinoma were analyzed in a multi-institutional study. Among them, 166 optimally debulked women with stage IIB-IV CCC were collected (residual tumor of
Source: Journal of Gynecologic Oncology - February 8, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

LAMC1 is a prognostic factor and a potential therapeutic target in endometrial cancer.
CONCLUSION: LAMC1 overexpression is a potent biomarker for identifying endometrial cancer patients needing aggressive adjuvant therapy. We elucidated 8 candidate genes that may mediate progression of LAMC1 overexpressing cancer. Further investigation of the underlying mechanism should lead to the discovery of new therapeutic targets. PMID: 31912669 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - January 10, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Efficacy and safety of neoadjuvant chemotherapy versus primary debulking surgery in patients with ovarian cancer: a meta-analysis.
Authors: Lv X, Cui S, Zhang X, Ren C Abstract OBJECTIVE: Neoadjuvant chemotherapy (NACT) for the treatment of epithelial ovarian cancer (EOC) has remained controversial. This meta-analysis was performed to systematically assess the efficacy and safety of NACT versus primary debulking surgery (PDS) in patients with EOC. METHODS: PubMed, Embase, ClinicalTrials.gov, and Cochrane Library were queried to assess the therapeutic value of NACT versus PDS in EOC. Electronic databases were queried by using the keywords "ovarian cancer/neoplasms", "primary debulking surgery", and "neoadjuvant chem...
Source: Journal of Gynecologic Oncology - January 10, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Pathologic discrepancies between colposcopy-directed biopsy and loop electrosurgical excision procedure of the uterine cervix in women with cytologic high-grade squamous intraepithelial lesions.
Authors: Kim SI, Kim SJ, Suh DH, Kim K, No JH, Kim YB Abstract OBJECTIVE: To investigate pathologic discrepancies between colposcopy-directed biopsy (CDB) of the cervix and loop electrosurgical excision procedure (LEEP) in women with cytologic high-grade squamous intraepithelial lesions (HSILs). METHODS: We retrospectively identified 297 patients who underwent both CDB and LEEP for HSILs in cervical cytology between 2015 and 2018, and compared their pathologic results. Considering the LEEP to be the gold standard, we evaluated the diagnostic performance of CDB for identifying cervical intraepithelial neoplasia ...
Source: Journal of Gynecologic Oncology - January 10, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Tozzi classification of diaphragmatic surgery in patients with stage IIIC-IV ovarian cancer based on surgical findings and complexity.
CONCLUSION: Diaphragmatic surgery can be classified in 3 types. The adoption of this classification can facilitate standardization of the surgery, comparison of data and define the expertise required. Finally, this classification can be a benchmark to establish the training required to treat diaphragmatic disease. PMID: 31912672 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - January 10, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Real world effectiveness and safety of pegylated liposomal doxorubicin in platinum-sensitive recurrent ovarian, fallopian, or primary peritoneal cancer: a Korean multicenter retrospective cohort study.
CONCLUSIONS: The safety and effectiveness of chemotherapy with CD in a real-world setting were consistent with the results from a randomized controlled study. The different toxicity profiles between the 2 chemotherapy (CD and CP) regimens should be considered in the clinical practice. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT03562533. PMID: 31912673 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - January 10, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Completion hysterectomy after chemoradiotherapy for locally advanced adeno-type cervical carcinoma: updated survival outcomes and experience in post radiation surgery.
CONCLUSION: Completion hysterectomy after CCRT was associated with better survival outcome compared with the current standard of care. PMID: 31912674 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - January 10, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Significance of PD-L1 expression in carbon-ion radiotherapy for uterine cervical adeno/adenosquamous carcinoma.
CONCLUSION: CIRT can induce PD-L1 expression in UCAA and we propose that PD-L1 expression after starting CIRT may become as a predictive prognostic marker in CIRT for UCAA. PMID: 31912675 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - January 10, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Human papillomavirus (HPV) DNA detection in uterine cervix cancer after radiation indicating recurrence: a systematic review and meta-analysis.
CONCLUSION: The screening for HPV DNA testing during follow-up facilitates early detection of recurrence after radiotherapy. PMID: 31912676 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - January 10, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Survival and recurrence in stage II endometrial cancers in relation to uterine risk stratification after introduction of lymph node resection and omission of postoperative radiotherapy: a Danish Gynecological Cancer Group Study.
Authors: Ørtoft G, Høgdall C, Hansen ES, Dueholm M Abstract OBJECTIVE: To evaluate survival and recurrence in stage II endometrial cancer in relation to uterine risk stratification. Outcome for stage II was compared before and after the introduction of lymph node (LN) resection and omission of all postoperative radiotherapy. METHODS: The cohort consisted of 4,380 endometrial carcinoma patients radically operated (no visual tumor, all distant metastasis removed) (2005-2012) including 461 stage II. Adjusted Cox regression was used to compare survival and actuarial recurrence rates. RESULTS: Uter...
Source: Journal of Gynecologic Oncology - January 10, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Comparison between weekly versus 3-weekly paclitaxel in combination with carboplatin as neoadjuvant chemotherapy in advanced ovarian cancer.
Authors: Kim YN, Lee YJ, Lee JY, Nam EJ, Kim SW, Kim S, Kim YT Abstract OBJECTIVE: To compare the efficacy and toxicity of dose-dense weekly paclitaxel and 3-weekly carboplatin (ddPC) as neoadjuvant chemotherapy (NAC) with the standard 3-weekly regimen. METHODS: A retrospective study of patients diagnosed with stage IIIc and IV ovarian cancer who received at least one cycle of NAC followed by interval debulking surgery between August 2015 and January 2018 was conducted. Patient characteristics, clinical and pathological response to NAC, surgical and survival outcome, and adverse event were compared. RESULTS...
Source: Journal of Gynecologic Oncology - January 10, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

BRCA1/2 mutation status in patients with metachronous breast and ovarian malignancies: clues towards the implementation of genetic counseling.
CONCLUSIONS: Our results provide pilot evidence that BRCA1/2 mutations are common in Taiwanese patients with metachronous breast and ovarian malignancies, supporting the clinical utility of genetic counseling. PMID: 31912679 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - January 10, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Primary sarcoma of the cervix: an analysis of patient and tumor characteristics, treatment patterns, and outcomes.
Authors: Albert A, Lee A, Allbright R, Vijayakumar S Abstract OBJECTIVE: Primary sarcoma of the cervix is rare and is associated with worse outcomes as compared to other histologies. The purpose of this study was to identify national treatment patterns and outcomes based on histological subtype using the National Cancer Database (NCDB). METHODS: The NCDB was queried for patients with cervical cancer from 2004-2015. Clinico-demographic treatment details were obtained and compared between patients with squamous cell carcinoma (SCC), adenocarcinoma, and sarcoma of the cervix. Multivariable Cox regression and the K...
Source: Journal of Gynecologic Oncology - January 10, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Prognostic significance of lymphovascular space invasion in patients with endometrioid endometrial cancer: a retrospective study from a single center.
This study aims to analyze factors associated with lymphovascular space invasion (LVSI) and evaluate the prognostic significance of LVSI in Chinese endometrioid endometrial cancer (EEC) patients. METHODS: Five-hundred eighty-four EEC patients undergoing surgery in our center from 2006 to 2016 were selected for analysis. Univariate analysis and multivariate logistic regression were used to examine relevant factors of LVSI. To evaluate the prognostic role of LVSI, survival analyses were conducted. In survival analyses, both multivariate Cox regression and propensity score matching were used to control the confounders. ...
Source: Journal of Gynecologic Oncology - January 10, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Quantitative analysis of proteins related to chemoresistance to paclitaxel and carboplatin in human SiHa cervical cancer cells via iTRAQ.
CONCLUSION: This study is the first to use iTRAQ to identify paclitaxel- and carboplatin- resistance proteins in cervical cells. We identified several proteins previously unassociated with paclitaxel and carboplatin resistance in cervical cancer, thereby expanding our understanding of paclitaxel and carboplatin resistance mechanisms. Moreover, these findings indicate that the APOA1 protein could serve as a potential marker for monitoring and predicting paclitaxel and carboplatin resistance levels. PMID: 31912682 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - January 10, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Sensitizing endometrial cancer to ionizing radiation by multi-tyrosine kinase inhibition.
CONCLUSIONS: Our results provide the rationale of using sunitinib as neoadjuvant treatment prior radiotherapy which could be a starting point for the implementation of sunitinib and radiotherapy in the clinic for the treatment of recalcitrant endometrial cancers. PMID: 31912683 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - January 10, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Microscopic diseases remain in initial disseminated sites after neoadjuvant chemotherapy for stage III/IV ovarian, tubal, and primary peritoneal cancer.
CONCLUSION: Even if a disseminated site>1 cm in diameter before NACT is invisible during IDS, microscopic disease remains present within it. The appropriate surgical margins for IDS with a favorable prognosis could be secured by resecting a lesion of>1 cm before NACT even if it is invisible during IDS. PMID: 31912684 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - January 10, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Chemoradiotherapy is not superior to radiotherapy alone after radical surgery for cervical cancer patients with intermediate-risk factor.
CONCLUSION: The present study showed that giving RT together with chemotherapy is not more effective than RT alone for stage IB-IIA cervical cancer patients with intermediate-risk factor(s). TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT01101451. PMID: 31912685 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - January 10, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Survival benefit of radiation in high-risk, early-stage endometrioid carcinoma.
Authors: Xiang M, Kidd EA Abstract OBJECTIVE: To better delineate optimal management of high-risk, early-stage endometrial cancer, as national guidelines permit substantial practice variations. METHODS: Patients with International Federation of Gynecology and Obstetrics (FIGO) stage IB grade 3 and stage II endometrioid carcinoma who underwent at least total hysterectomy were identified in SEER-Medicare. Adjuvant treatments were brachytherapy (BT), external beam radiation therapy (EBRT), and chemotherapy. Death from endometrial cancer (cancer-specific mortality [CSM]) and local recurrence were analyzed using Gra...
Source: Journal of Gynecologic Oncology - January 10, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Safety evaluation of abdominal trachelectomy in patients with cervical tumors ≥2 cm: a single-institution, retrospective analysis.
Safety evaluation of abdominal trachelectomy in patients with cervical tumors ≥2 cm: a single-institution, retrospective analysis. J Gynecol Oncol. 2019 Dec 18;: Authors: Okugawa K, Yahata H, Sonoda K, Ohgami T, Yasunaga M, Kaneki E, Kato K Abstract OBJECTIVE: For oncologic safety, vaginal radical trachelectomy is generally performed only in patients with cervical cancers smaller than 2 cm. However, because inclusion criteria for abdominal trachelectomy are controversial, we evaluated the safety of abdominal trachelectomy for cervical cancers ≥2 cm. METHODS: We began performing abdominal trac...
Source: Journal of Gynecologic Oncology - January 10, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Characteristics and survival of ovarian cancer patients treated with neoadjuvant chemotherapy but not undergoing interval debulking surgery.
Authors: Liu YL, Filippova OT, Zhou Q, Iasonos A, Chi DS, Zivanovic O, Sonoda Y, Gardner GJ, Broach VA, O'Cearbhaill RE, Konner JA, Aghajanian C, Long Roche K, Tew WP Abstract OBJECTIVE: Neoadjuvant chemotherapy (NACT) followed by interval debulking surgery (IDS) confers similar outcomes as primary debulking surgery and chemotherapy. Little is known about patients who receive NACT but do not undergo debulking surgery. Our aim was to characterize these patients. METHODS: We prospectively identified patients with newly diagnosed stage III/IV ovarian cancer treated with NACT from 7/1/15-12/1/17. Fisher exact and W...
Source: Journal of Gynecologic Oncology - December 14, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

The basic principles of oncologic surgery during minimally invasive radical hysterectomy.
Authors: Köhler C, Schneider A, Marnitz S, Plaikner A PMID: 31833260 [PubMed - in process] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - December 14, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

The 6th Biennial Meeting of the Asian Society of Gynecologic Oncology, October 10th to 12th, 2019.
Authors: Charoenkwan K, Wilailak S PMID: 31833261 [PubMed - in process] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - December 14, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

The role of direct oral anticoagulants in venous thromboembolic disease in gynecologic cancer.
Authors: Park JY PMID: 31833262 [PubMed - in process] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - December 14, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

The prognostic value of lymph node ratio in stage IIIC cervical cancer patients triaged to primary treatment by radical hysterectomy with systematic pelvic and para-aortic lymphadenectomy.
Authors: Aslan K, Meydanli MM, Oz M, Tohma YA, Haberal A, Ayhan A Abstract OBJECTIVE: The aim of this study was to determine the prognostic value of lymph node ratio (LNR) in women with 2018 International Federation of Gynecology and Obstetrics stage IIIC cervical cancer. METHODS: In this retrospective dual-institutional study, a total of 185 node-positive cervical cancer patients who had undergone radical hysterectomy with systematic pelvic and para-aortic lymphadenectomy were included. All of the patients received adjuvant chemoradiation after surgery. LNR was defined as the ratio of positive lymph nodes (LNs...
Source: Journal of Gynecologic Oncology - December 4, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Clinical response and safety of apatinib monotherapy in recurrent, metastatic cervical cancer after failure of chemotherapy: a retrospective study.
CONCLUSIONS: Apatinib can improve the disease control rate of recurrent and metastatic cervical cancer when chemotherapy has failed, and the treatment is well tolerated. This represents that apatinib may be a new treatment option for metastatic cervical cancer patients. PMID: 31788992 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - December 4, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Well-trained gynecologic oncologists can perform bowel resection and upper abdominal surgery safely.
CONCLUSION: Bowel resection and upper abdominal surgery can be performed safely by gynecologic oncologists. PMID: 31788993 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - December 4, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Status of HPV vaccination among HPV-infected women aged 20-60 years with abnormal cervical cytology in South Korea: a multicenter, retrospective study.
CONCLUSION: This study highlighted the status of HPV vaccination and the prevalence of HPV-16/18 genotypes among HPV-infected women with abnormal cervical cytology according to HPV vaccination. It provides preliminary information regarding the status of HPV vaccination among Korean adult women. PMID: 31788994 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - December 4, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Maintenance of pegylated liposomal doxorubicin/carboplatin in patients with advanced ovarian cancer: randomized study of an Asian Gynecologic Oncology Group.
Authors: Lai CH, Vallikad E, Lin H, Yang LY, Jung SM, Liu HE, Ou YC, Chou HH, Lin CT, Huang HJ, Huang KG, Qiu J, Hung YC, Wu TI, Chang WY, Tan KT, Lin CY, Chao A, Chang CJ Abstract OBJECTIVES: An Asian Gynecologic Oncology Group phase III randomized trial was conducted to determine whether maintenance chemotherapy could improve progression-free survival (PFS) in stages III/IV ovarian cancer. METHODS: Between 2007 and 2014, 45 newly-diagnosed ovarian cancer patients were enrolled after complete remission and randomized (1:1) to arm A (4-weekly carboplatin area under the curve 4 and pegylated liposomal doxorubici...
Source: Journal of Gynecologic Oncology - December 4, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

ToleRability of BevacizUmab in elderly Ovarian cancer patients (TURBO study): a case-control study of a real-life experience.
Authors: Amadio G, Marchetti C, Villani ER, Fusco D, Stollagli F, Bottoni C, Distefano M, Colloca G, Scambia G, Fagotti A Abstract OBJECTIVE: Bevacizumab maintenance following platinum-based chemotherapy is an effective treatment for epithelial ovarian cancer (EOC), both in primary and recurrent disease. Our aim was to identify criteria to select elderly patients who can safely benefit from bevacizumab addition. METHODS: This is a case-control study on patients with primary or recurrent EOC who received platinum-based chemotherapy plus bevacizumab, between January 2015 and December 2016. Patient characteristics...
Source: Journal of Gynecologic Oncology - December 4, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Selection criteria and colpotomic approach for safe minimally invasive radical hysterectomy in early-stage cervical cancer.
Authors: Kong TW, Son JH, Paek J, Chang SJ, Ryu HS Abstract OBJECTIVE: To evaluate oncologic outcomes of minimally invasive radical hysterectomy (RH) in early cervical cancer before and after the application of parametrial invasion (PMI) criterion on magnetic resonance imaging (MRI) and vaginal colpotomy (VC). METHODS: A total of 216 International Federation of Gynecology and Obstetrics stage IB-IIA cervical cancer patients who underwent minimally invasive RH was identified between April 2006 and October 2018. Patients were classified into the pre-PMI intracorporeal or VC (IVC) (n=117) and post-PMI VC groups (n...
Source: Journal of Gynecologic Oncology - December 4, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Surgery of primary sites for stage IVB cervical cancer patients receiving chemoradiotherapy: a population-based study.
Authors: Li H, Pang Y, Cheng X Abstract OBJECTIVE: The purpose of this study was to analyze the impact of surgery of primary sites on stage IVB cervical cancer patients from a population-based database, the Surveillance, Epidemiology and End Results (SEER). METHODS: Propensity score matching was performed to minimize heterogeneity in patient between with-surgery group and without-surgery group. Clinicopathological characteristics were compared using the χ² or Fisher's exact test. Survival analysis included the Kaplan-Meier method, log-rank test, and Cox proportional hazards model. RESULTS: Between ...
Source: Journal of Gynecologic Oncology - December 4, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

An optimized BRCA1/2 next-generation sequencing for different clinical sample types.
CONCLUSIONS: On the comparison of the analytical performance according to different sample types, the buffy coat was not affected by sequencing artifacts and VAF shifted variants. Therefore, the blood test should be given priority in detecting germline BRCA1/2 mutation, and tumor materials could be suitable to detect somatic mutations in OC patients without identifying germline BRCA1/2 mutation. PMID: 31788999 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - December 4, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Comparison of rivaroxaban and dalteparin for the long-term treatment of venous thromboembolism in patients with gynecologic cancers.
CONCLUSION: In this study, although there were no significant differences in effectiveness or safety between the rivaroxaban and dalteparin groups, rivaroxaban use was associated with a higher rate of clinically relevant bleeding than dalteparin. Therefore, caution should be taken when prescribing rivaroxaban for gynecologic cancer-associated VTE and bleeding events should be carefully monitored. PMID: 31789000 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - December 4, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Japan Society of Gynecologic Oncology 2018 guidelines for treatment of uterine body neoplasms.
Authors: Yamagami W, Mikami M, Nagase S, Tabata T, Kobayashi Y, Kaneuchi M, Kobayashi H, Yamada H, Hasegawa K, Fujiwara H, Katabuchi H, Aoki D Abstract The Fourth Edition of the Guidelines for Treatment of Uterine Body Neoplasm was published in 2018. These guidelines include 9 chapters: 1. Overview of the guidelines, 2. Initial treatment for endometrial cancer, 3. Postoperative adjuvant therapy for endometrial cancer, 4. Post-treatment surveillance for endometrial cancer, 5. Treatment for advanced or recurrent endometrial cancer, 6. Fertility-sparing therapy, 7. Treatment of uterine carcinosarcoma and uterine sarco...
Source: Journal of Gynecologic Oncology - December 4, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

How to predict treatment failure in frail patients with advanced epithelial ovarian cancer: strategies to personalize surgical effort.
Authors: Fotopoulou C PMID: 31789002 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - December 4, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

High-risk human papillomavirus testing as a primary screening for cervical cancer: position statement by the Korean Society of Obstetrics and Gynecology and the Korean Society of Gynecologic Oncology.
Authors: Kong TW, Kim M, Kim YH, Kim YB, Kim J, Kim JW, Park MH, Park JH, Rhee JH, Lim MC, Hong JS Abstract Based on emerging data and current knowledge regarding high-risk human papillomavirus (hrHPV) testing as a primary screening for cervical cancer, the Korean Society of Obstetrics and Gynecology and the Korean Society of Gynecologic Oncology support the following scientific facts: • Compared to cytology, hrHPV screening has higher sensitivity and detects more cases of high-grade cervical intraepithelial neoplasia. • Qualified hrHPV testing can be considered as an alternative primary screening for cer...
Source: Journal of Gynecologic Oncology - December 4, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

A significant measure of HPV vaccine effectiveness in a high-risk population in Korea prior to a National Immunization Program.
Authors: Garland S PMID: 31789004 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - December 4, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

The power of the Risk of Ovarian Malignancy Algorithm considering menopausal status: a comparison with CA 125 and HE4.
CONCLUSION: The discrimination power of tumor markers for ovarian cancer was different according to menopausal status. In predicting ovarian malignancy, ROMA was neither superior to HE4 in premenopausal women nor superior to CA 125 in postmenopausal women. PMID: 31576682 [PubMed - in process] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - October 4, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Prognostic value of neutrophil-to-lymphocyte ratio in early-stage ovarian clear-cell carcinoma.
CONCLUSION: Results suggest that NLR can be a significant independent prognostic factor for early-stage OCCC. PMID: 31576683 [PubMed - in process] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - October 4, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

A phase 1/2a, dose-escalation, safety and preliminary efficacy study of oral therapeutic vaccine in subjects with cervical intraepithelial neoplasia 3.
Authors: Park YC, Ouh YT, Sung MH, Park HG, Kim TJ, Cho CH, Park JS, Lee JK Abstract OBJECTIVE: Persistent infection of HPV increases the chance of carcinoma in situ of cervix through stages of cervical intraepithelial neoplasia (CIN) 1, 2, and 3, and finally progresses into cervical cancer. We aimed to explore the safety and efficacy of BLS-M07 which is orally administered agent expressing human papillomavirus (HPV) 16 E7 antigen on the surface of Lactobacillus casei in patients with CIN 3. METHODS: Patients with CIN 3 were recruited in our clinical trial. Reid Colposcopic Index (RCI) grading and serum HPV16 E...
Source: Journal of Gynecologic Oncology - October 4, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Prognostic value of metabolic tumor volume and total lesion glycolysis from ¹⁸F-FDG PET/CT in lymph node metastases and risk stratification of endometrial carcinoma.
Prognostic value of metabolic tumor volume and total lesion glycolysis from ¹⁸F-FDG PET/CT in lymph node metastases and risk stratification of endometrial carcinoma. J Gynecol Oncol. 2019 Nov;30(6):e89 Authors: Liu DD, Li J, Li X, Xie L, Qin L, Peng F, Cheng MH Abstract OBJECTIVE: To investigate the prognostic value of metabolic tumor volume (MTV) and total lesion glycolysis (TLG), measured by preoperative ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT), in risk stratification of patients with endometrial carcinoma (EC). METHODS: The pat...
Source: Journal of Gynecologic Oncology - October 4, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Long-term outcomes of progestin plus metformin as a fertility-sparing treatment for atypical endometrial hyperplasia and endometrial cancer patients.
Authors: Mitsuhashi A, Habu Y, Kobayashi T, Kawarai Y, Ishikawa H, Usui H, Shozu M Abstract OBJECTIVE: The present study investigated long-term outcomes of medroxyprogesterone acetate (MPA) plus metformin therapy in terms of control of atypical endometrial hyperplasia (AEH) and endometrial cancer (EC), and post-treatment conception. METHODS: We retrospectively analyzed 63 patients (42 with EC; 21 with AEH) who underwent fertility-sparing management using MPA plus metformin. MPA (400 mg/day) and metformin (750-2,250 mg/day) were administered to achieve complete response (CR). Metformin was administered until con...
Source: Journal of Gynecologic Oncology - October 4, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Evaluation of non-completion of intraperitoneal chemotherapy in patients with advanced epithelial ovarian cancer.
Authors: Chambers LM, Son J, Radeva M, DeBernardo R Abstract OBJECTIVE: To identify factors associated with non-completion of intraperitoneal with intravenous chemotherapy [IP/IV] in women with epithelial ovarian cancer (EOC). METHODS: This was an Institutional Review Board approved, retrospective cohort study in women with stage III EOC following optimal cytoreductive surgery (CRS) (
Source: Journal of Gynecologic Oncology - October 4, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Investigating the role of immunotherapy in advanced/recurrent female genital tract melanoma: a preliminary experience.
CONCLUSION: Results from our series confirm the poor prognosis of women with metastatic melanoma of the lower genital tract, thus supporting the need of exploring new treatment modalities. Further studies are warranted to improve knowledge on the role of immunotherapy in metastatic melanoma of the lower genital tract. PMID: 31576688 [PubMed - in process] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - October 4, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research