Incidence and predictors of peritoneal metastases of gynecological origin: a population-based study in the Netherlands.
CONCLUSION: PM are frequently seen in patients with ovarian cancer. In endometrial and cervical cancer PM are rare. Histological subtype was the strongest predictive factor for PM in all 3 cancers. Better understanding of predictive factors for PM and thus the biological behavior is of paramount importance. PMID: 32808491 [PubMed - in process] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - August 20, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Age-specific predictors of cervical dysplasia recurrence after primary conization: analysis of 3,212 women.
CONCLUSION: HPV persistence is the main factor predicting r-CIN2+. Infection from HPV16/18 has a detrimental effect in young women, thus highlighting the need of implementing vaccination against HPV in this population. Further prospective studies are warranted for tailoring clinical decision-making for post-conization follow-up on the basis of risk factors. PMID: 32808492 [PubMed - in process] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - August 20, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Incidence and clinical course of septic shock in neutropenic patients during chemotherapy for gynecological cancers.
CONCLUSION: The overall incidence of NSS in gynecological cancer patients receiving chemotherapy was 3.0%, which is higher than previously estimated. Peak heart rate during NSS events may be an indicator for predicting survival. PMID: 32808493 [PubMed - in process] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - August 20, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Should indications for laterally extended endopelvic resection (LEER) exclude patients with sciatica?
CONCLUSION: Laparoscopic LEER for a laterally recurrent previously irradiated cervical cancer with concomitant sciatica was technically feasible, however, further study involving a greater number of patients and longer follow-up period is warranted to determine the stringent indications. PMID: 32808494 [PubMed - in process] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - August 20, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Survival implication of lymphadenectomy in patients surgically treated for apparent early-stage uterine serous carcinoma.
Authors: Casarin J, Bogani G, Piovano E, Falcone F, Ferrari F, Odicino F, Puppo A, Bonfiglio F, Donadello N, Pinelli C, Laganà AS, Ditto A, Malzoni M, Greggi S, Raspagliesi F, Ghezzi F Abstract OBJECTIVE: Uterine serous carcinoma (USC) is a rare highly aggressive disease. In the present study, we aimed to investigate the survival implication of the systematic lymphadenectomy in patients who underwent surgery for apparent early-stage USC. METHODS: Consecutive patients with apparent early-stage USC surgically treated at six Italian referral cancer centers were analyzed. A comparison was made between patien...
Source: Journal of Gynecologic Oncology - August 20, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Vulvar melanoma: an analysis of prognostic factors and treatment patterns.
CONCLUSIONS: Vulvar melanoma has a poor prognosis for those with regional and distant metastatic disease. Extent of disease, tumor size, and patient age are important prognostic factors. Other favorable factors included insurance and surgical management. The use of immunotherapy has increased over time and may improve survival in those with distant disease. These data support further investigation into the role of immunotherapy for vulvar melanoma to optimize outcomes. PMID: 32808496 [PubMed - in process] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - August 20, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Lymphadenectomy for primary ovarian cancer: a systematic review and meta-analysis.
CONCLUSIONS: Meta-analysis of RCTs and observational studies suggest that lymphadenectomy was associated with improved OS in advanced- and early-stage EOC. However, results from RCTs demonstrate that lymphadenectomy was not associated with improved OS in advanced- and early-stage EOC. PMID: 32808497 [PubMed - in process] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - August 20, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Feasibility of laparoscopic diaphragmatic peritonectomy during Visceral-Peritoneal Debulking (VPD) in patients with stage IIIC-IV ovarian cancer.
CONCLUSION: Diaphragmatic peritonectomy can be safely accomplished by laparoscopy in almost half of the patients with OC whose disease is limited to the diaphragmatic peritoneum. PMID: 32808498 [PubMed - in process] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - August 20, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Potential strategies for prevention of tumor spillage in minimally invasive radical hysterectomy.
CONCLUSION: As there is a biological rationale in these measures that would prevent tumor spillage and seeding, there is a need of prospectively exploring them within appropriate studies in order to determine their own oncological outcome. PMID: 32808499 [PubMed - in process] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - August 20, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Fertility-sparing treatment for intramucous, moderately differentiated, endometrioid endometrial cancer: a Gynecologic Cancer Inter-Group (GCIG) study.
CONCLUSIONS: Fertility-sparing treatment seems to be feasible even in G2 EC, although caution should be kept considering the potential pathological undergrading or non-endometrioid histology misdiagnosis. The low rate of attempt to conceive and of compliance to definitive surgery underline the need for a 'global' counselling extended to the follow-up period. PMID: 32808500 [PubMed - in process] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - August 20, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Circulating exosomal circFoxp1 confers cisplatin resistance in epithelial ovarian cancer cells.
CONCLUSIONS: circFoxp1 is an oncogene in EOC cells and can confer DDP resistance to EOC cells. Circulating exosomal circFoxp1 can be used as a biomarker and potential therapeutic target for EOC. PMID: 32808501 [PubMed - in process] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - August 20, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Comprehensive pelvic and paraaortic lymphadenectomy in patients with apparently early stage uterine serous carcinoma - an anachronism?
Authors: Emons G PMID: 32808502 [PubMed - in process] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - August 20, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Pushing the envelope: expanding fertility sparing treatment of endometrial cancer.
Authors: Stewart KI, Yates MS, Westin SN PMID: 32808503 [PubMed - in process] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - August 20, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Study of upfront surgery versus neoadjuvant chemotherapy followed by interval debulking surgery for patients with stage IIIC and IV ovarian cancer, SGOG SUNNY (SOC-2) trial concept.
Authors: Jiang R, Zhu J, Kim JW, Liu J, Kato K, Kim HS, Zhang Y, Zhang P, Zhu T, Aoki D, Yu A, Chen X, Wang X, Zhu D, Zhang W, Jia H, Shi T, Gao W, Yin S, Feng Y, Xiang L, Okamoto A, Zang R Abstract BACKGROUND: Two randomized phase III trials (EORTC55971 and CHORUS) showed similar progression-free and overall survival in primary or interval debulking surgery in ovarian cancer, however both studies had limitations with lower rate of complete resection and lack of surgical qualifications for participating centers. There is no consensus on whether neoadjuvant chemotherapy followed by interval debulking surgery (NACT-I...
Source: Journal of Gynecologic Oncology - August 20, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Erratum: Author Correction. Management of ovarian cancer patients in affected areas during COVID-19 pandemic: Japan and Korea.
Authors: Kobayashi Y, Suh DH, Tsuji K, Kim JY, Shin S, Aoki D, Kim JW Abstract This corrects the article on p. e65 in vol. 31, PMID: 32342678. PMID: 32808505 [PubMed] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - August 20, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Letter to editor in response to: Comparison of diagnostic accuracy between endometrial curettage and aspiration biopsy in patients treated with progestin for endometrial hyperplasia: a Korean Gynecologic Oncology Group study.
Authors: PMID: 32808506 [PubMed - in process] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - August 20, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Response to comment on: Comparison of diagnostic accuracy between endometrial curettage and aspiration biopsy in patients treated with progestin for endometrial hyperplasia: a Korean Gynecologic Oncology Group study.
Authors: PMID: 32808507 [PubMed - in process] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - August 20, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

FIGO staging in ovarian carcinoma and histological subtypes.
Authors: Kehoe S PMID: 32519520 [PubMed - in process] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - June 12, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Recommendations on management of gynecological malignancies during the COVID-19 pandemic: perspectives from Chinese gynecological oncologists.
Authors: Wang Y, Zhang S, Wei L, Lin Z, Wang X, Wang J, Hua K, Cui M, Wang J, Wang S, Di W, Wang Y, An R, Xi M, Guo R, Zhou Q, Xie X, Xue F Abstract The outbreak of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 has rapidly spread globally. Cancer patients are at a higher risk of being infected with the coronavirus and are more likely to develop severe complications, as compared to the general population. The increasing spread of COVID-19 presents challenges for the clinical care of patients with gynecological malignancies. Concerted efforts should be put into mana...
Source: Journal of Gynecologic Oncology - May 29, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Gynecologic oncology at the time of COVID-19 outbreak.
Authors: Bogani G, Brusadelli C, Guerrisi R, Lopez S, Signorelli M, Ditto A, Raspagliesi F Abstract The World Health Organization (WHO) classified the novel coronavirus (i.e., coronavirus disease 2019 [COVID-19]) as a global public health emergency. COVID-19 threatens to curtail patient access to evidence-based treatment. Medicine is changing, basically due to the limited available resources. In the field of gynecologic oncology, we have to re-design our treatments' paradigm. During COVID-19 pandemic outbreak, the highest priority is to achieve the maximum benefit from less demanding procedures. Extensive procedure...
Source: Journal of Gynecologic Oncology - May 29, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Recommendations for gynecologic cancer care during the COVID-19 pandemic.
Authors: PMID: 32406213 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - May 16, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Epithelial ovarian cancer: a review of preoperative imaging features indicating suboptimal surgery.
Authors: Jeong SY, Kim TJ, Park BK Abstract Epithelial ovarian cancer has been traditionally treated with cytoreductive surgery and chemotherapy. Optimal surgery is the key to improving the prognosis, and, thus, preoperative imaging should be carefully assessed to determine if the involvement of gastrointestinal, vascular, or thoracic surgeons is necessary to achieve this. Consequently, gynecologists should be able to recognize which imaging features suggest optimal or suboptimal resection. The aim of this review was to present the preoperative imaging features indicating suboptimal resection of epithelial ovarian ...
Source: Journal of Gynecologic Oncology - April 30, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Management of ovarian cancer patients in affected areas during COVID-19 pandemic: Japan and Korea.
Authors: Kobayashi Y, Suh DH, Aoki D, Kim JW PMID: 32342678 [PubMed - in process] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - April 29, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Major clinical research advances in gynecologic cancer in 2019.
Authors: Kim M, Suh DH, Lee KH, Eom KY, Lee JY, Lee YY, Hansen HF, Mirza MR, Kim JW Abstract In 2019, 12 topics were selected as the major research advances in gynecologic oncology. Herein, we first opted to introduce the significant clinical activity of pembrolizumab in women with advanced cervical cancer based on the results of the phase 2 KEYNOTE-158 trial. Thereafter, we reviewed 5 topics, including systemic lymphadenectomy in the advanced stage with no gross residual tumor, secondary cytoreductive surgery in recurrent ovarian cancer according to the results of Gynecologic Oncology Group-213 trial, dose-dense w...
Source: Journal of Gynecologic Oncology - April 23, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

A phase II, randomized study of cytoreductive surgery combined with niraparib maintenance in platinum-sensitive, secondary recurrent ovarian cancer: SGOG SOC-3 study.
Authors: Shi T, Yin S, Zhu J, Zhang P, Liu J, Zhu Y, Wu S, Chen X, Wang X, Teng Y, Zhu T, Yu A, Zhang Y, Feng Y, Huang H, Bao W, Li Y, Jiang W, Zhang P, Li J, Ai Z, Zhang W, Jia H, Zhang Y, Jiang R, Zhang J, Gao W, Luan Y, Zang R Abstract BACKGROUND: In China, secondary cytoreductive surgery (SCR) has been widely used in ovarian cancer (OC) over the past two decades. Although Gynecologic Oncology Group-0213 trial did not show its overall survival benefit in first relapsed patients, the questions on patient selection and effect of subsequent targeting therapy are still open. The preliminary data from our pre-SOC1 ph...
Source: Journal of Gynecologic Oncology - April 23, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Characterizing the efficacy and trends of adjuvant therapy versus observation in women with early stage (uterine confined) leiomyosarcoma: a National Cancer Database study.
CONCLUSION: Although women with uterine confined leiomyosarcoma experience high recurrence rates and poor survival outcomes, adjuvant treatment does not appear to confer a survival benefit. PMID: 32266798 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - April 9, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Nerve-sparing radical hysterectomy in the precision surgery for cervical cancer.
Authors: Sakuragi N, Murakami G, Konno Y, Kaneuchi M, Watari H Abstract Precision cancer surgery is a system that integrates the accurate evaluation of tumor extension and aggressiveness, precise surgical maneuvers, prognosis evaluation, and prevention of the deterioration of quality of life (QoL). In this regard, nerve-sparing radical hysterectomy has a pivotal role in the personalized treatment of cervical cancer. Various types of radical hysterectomy can be combined with the nerve-sparing procedure. The extent of parametrium and vagina/paracolpium excision and the nerve-sparing procedure are tailored to the tumo...
Source: Journal of Gynecologic Oncology - April 9, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Comparison of diagnostic accuracy between endometrial curettage and aspiration biopsy in patients treated with progestin for endometrial hyperplasia: a Korean Gynecologic Oncology Group study.
CONCLUSION: As a follow-up evaluation of patients treated with progestin for EH, aspiration biopsy is less accurate than D&C and might not be a reliable method. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT02412072. PMID: 32266800 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - April 9, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Economic burden and treatment patterns of gynecologic cancers in the United States: evidence from the Medical Expenditure Panel Survey 2007-2014.
This study estimated nationally representative medical expenditures of gynecologic cancers, described treatment patterns and assessed key risk factors associated with the economic burden in the United States. METHODS: A retrospective repeated measures design was used to estimate the effect of gynecologic cancers on medical expenditures and utilization among women. Data were extracted from the Medical Expenditure Panel Survey (weighted sample of 609,787 US adults) from 2007 to 2014. Using the behavioral model of health services utilization, characteristics of cancer patients were examined and compared among uterine, cer...
Source: Journal of Gynecologic Oncology - April 9, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Stage III uterine serous carcinoma: modern trends in multimodality treatment.
CONCLUSION: Modern era treatment was associated with improved RFS and OS in patients with stage III USC. Regional nodal recurrences were significantly reduced in patients who received EBRT. PMID: 32266802 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - April 9, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Management of patients with intermediate-risk early stage cervical cancer.
Authors: Cibula D PMID: 32266803 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - April 9, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

National screening programs for cervical cancer in Asian countries.
Authors: Saitoh Aoki E, Yin R, Li K, Bhatla N, Singhal S, Ocviyanti D, Saika K, Suh M, Kim M, Termrungruanglert W Abstract Cervical cancer is still one of the most common female cancers in Asia and the leading cause of cancer-related deaths in low- and middle-income countries. Nowadays, national screening programs for cervical cancer are widely provided in Asian countries. We reviewed the National Cancer Screening Program (NCSP) in China, India, Indonesia, Japan, Korea, and Thailand. The NCSP were established at varying times, from 1962 in Japan to 2014 in Indonesia. The primary screening method is based on cytolog...
Source: Journal of Gynecologic Oncology - April 9, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Incidence trends for epithelial peritoneal, ovarian, and fallopian tube cancer during 1999-2016: a retrospective study based on the Korean National Cancer Incidence Database.
CONCLUSION: The overall incidence of PPC, OC, and FTC cancer has steadily increased. The relative increase of PPC and FTC has been significant. In this study, OC incidence had a relatively young peak age, in contrast to FTC and PPC, which had an older peak age. PMID: 32266805 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - April 9, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Robot assisted surgery during the COVID-19 pandemic, especially for gynecological cancer: a statement of the Society of European Robotic Gynaecological Surgery (SERGS).
Authors: Kimmig R, Verheijen RHM, Rudnicki M, SERGS Council Abstract All surgery performed in an epicenter of the coronavirus disease 2019 (COVID-19) pandemic, irrespective of the known or suspected severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) status of the patient, should be regarded as high risk and protection of the surgical team at the bedside should be at the highest level. Robot assisted surgery (RAS) may help to reduce hospital stay for patients that urgently need complex-oncological-surgery, thus making room for COVID-19 patients. In comparison to open or conventional laparoscopic surgery, R...
Source: Journal of Gynecologic Oncology - April 5, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Comments on: a phase 1/2a, dose-escalation, safety and preliminary efficacy study of oral therapeutic vaccine in subjects with cervical intraepithelial neoplasia 3.
Authors: Zhang N, Wang H, Yang J PMID: 32100488 [PubMed - in process] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - February 28, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

In reply: the evaluation of IgG titers' stability from blood samples is necessary.
Authors: Ouh YT, Lee JK PMID: 32100489 [PubMed - in process] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - February 28, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Stage II endometrial cancer requires stratification according to uterine risk factor and sentinel lymph node sampling.
Authors: Ouh YT, Min KJ PMID: 32100490 [PubMed - in process] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - February 28, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Risk factors for early death among ovarian cancer patients: a nationwide cohort study.
CONCLUSIONS: Despite several admissions to hospital, the ovarian cancer diagnosis is delayed for a subgroup of patients, who end up dying early, probably due to physical deterioration in the ineffective waiting time. Up to 90% of high-risk patients might be identified significantly earlier to improve the prognosis. The admittance of the patients having risk symptoms should include fast track investigation for ovarian cancer. PMID: 32026656 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - February 8, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

The 16-year experience in treating low-risk gestational trophoblastic neoplasia patients with failed primary methotrexate chemotherapy.
CONCLUSION: Based on the good therapeutic effect and tolerable toxicity, we recommend Act-D salvage therapy for all patients with low-risk GTN who fail primary MTX chemotherapy. The higher serum hCG levels before Act-D salvage therapy may be associated with resistance to this treatment. PMID: 32026657 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - February 8, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Comparing efficacy of high-dose rate brachytherapy versus helical tomotherapy in the treatment of cervical cancer.
CONCLUSIONS: HT boost treatment showed comparable disease outcomes with those observed with conventional BT in patients with advanced cervical cancer. HT could be a complementary boost protocol as a single modality or hybrid with BT in selected patients. Further studies with longer follow-up periods are warranted to confirm long-term outcomes. PMID: 32026658 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - February 8, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

A retrospective study for investigating the relationship between old and new staging systems with prognosis in ovarian cancer using gynecologic cancer registry of Japan Society of Obstetrics and Gynecology (JSOG): disparity between serous carcinoma and clear cell carcinoma.
Authors: Yamagami W, Nagase S, Takahashi F, Ino K, Hachisuga T, Mikami M, Enomoto T, Katabuchi H, Aoki D Abstract OBJECTIVE: International Federation of Gynecology and Obstetrics (FIGO) staging for ovarian, fallopian tube, and peritoneal cancers was revised in 2014. The aim of this study is to clarify whether the revised FIGO2014 staging reflects the prognosis of patients with ovarian cancer by histological type in Japan. METHODS: We extracted 9,747 patients who were diagnosed with ovarian cancer since 2004 until 2008 and who could be classified into appropriate stages from the Gynecologic Cancer Registry of Ja...
Source: Journal of Gynecologic Oncology - February 8, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

SURF4 maintains stem-like properties via BIRC3 in ovarian cancer cells.
CONCLUSION: Our findings suggest that SURF4 possesses the ability to maintain stemness of OCSCs via BIRC3, and may serve as a potential target in stem cell-targeted therapy for ovarian cancer. PMID: 32026660 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - February 8, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

The impact of systematic retroperitoneal lymphadenectomy on long-term oncologic outcome of women with advanced ovarian clear-cell carcinoma.
Authors: Kajiyama H, Suzuki S, Yoshikawa N, Tamauchi S, Shibata K, Kikkawa F Abstract OBJECTIVE: The impact of systematic retroperitoneal lymphadenectomy (SRL) remains controversial in patients with advanced ovarian clear-cell carcinoma (CCC) who are optimally debulked. METHODS: Between 1986 and 2017, a total of 3,227 women with epithelial ovarian carcinoma were analyzed in a multi-institutional study. Among them, 166 optimally debulked women with stage IIB-IV CCC were collected (residual tumor of
Source: Journal of Gynecologic Oncology - February 8, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

LAMC1 is a prognostic factor and a potential therapeutic target in endometrial cancer.
CONCLUSION: LAMC1 overexpression is a potent biomarker for identifying endometrial cancer patients needing aggressive adjuvant therapy. We elucidated 8 candidate genes that may mediate progression of LAMC1 overexpressing cancer. Further investigation of the underlying mechanism should lead to the discovery of new therapeutic targets. PMID: 31912669 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - January 10, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Efficacy and safety of neoadjuvant chemotherapy versus primary debulking surgery in patients with ovarian cancer: a meta-analysis.
Authors: Lv X, Cui S, Zhang X, Ren C Abstract OBJECTIVE: Neoadjuvant chemotherapy (NACT) for the treatment of epithelial ovarian cancer (EOC) has remained controversial. This meta-analysis was performed to systematically assess the efficacy and safety of NACT versus primary debulking surgery (PDS) in patients with EOC. METHODS: PubMed, Embase, ClinicalTrials.gov, and Cochrane Library were queried to assess the therapeutic value of NACT versus PDS in EOC. Electronic databases were queried by using the keywords "ovarian cancer/neoplasms", "primary debulking surgery", and "neoadjuvant chem...
Source: Journal of Gynecologic Oncology - January 10, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Pathologic discrepancies between colposcopy-directed biopsy and loop electrosurgical excision procedure of the uterine cervix in women with cytologic high-grade squamous intraepithelial lesions.
Authors: Kim SI, Kim SJ, Suh DH, Kim K, No JH, Kim YB Abstract OBJECTIVE: To investigate pathologic discrepancies between colposcopy-directed biopsy (CDB) of the cervix and loop electrosurgical excision procedure (LEEP) in women with cytologic high-grade squamous intraepithelial lesions (HSILs). METHODS: We retrospectively identified 297 patients who underwent both CDB and LEEP for HSILs in cervical cytology between 2015 and 2018, and compared their pathologic results. Considering the LEEP to be the gold standard, we evaluated the diagnostic performance of CDB for identifying cervical intraepithelial neoplasia ...
Source: Journal of Gynecologic Oncology - January 10, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Tozzi classification of diaphragmatic surgery in patients with stage IIIC-IV ovarian cancer based on surgical findings and complexity.
CONCLUSION: Diaphragmatic surgery can be classified in 3 types. The adoption of this classification can facilitate standardization of the surgery, comparison of data and define the expertise required. Finally, this classification can be a benchmark to establish the training required to treat diaphragmatic disease. PMID: 31912672 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - January 10, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Real world effectiveness and safety of pegylated liposomal doxorubicin in platinum-sensitive recurrent ovarian, fallopian, or primary peritoneal cancer: a Korean multicenter retrospective cohort study.
CONCLUSIONS: The safety and effectiveness of chemotherapy with CD in a real-world setting were consistent with the results from a randomized controlled study. The different toxicity profiles between the 2 chemotherapy (CD and CP) regimens should be considered in the clinical practice. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT03562533. PMID: 31912673 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - January 10, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Completion hysterectomy after chemoradiotherapy for locally advanced adeno-type cervical carcinoma: updated survival outcomes and experience in post radiation surgery.
CONCLUSION: Completion hysterectomy after CCRT was associated with better survival outcome compared with the current standard of care. PMID: 31912674 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - January 10, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Significance of PD-L1 expression in carbon-ion radiotherapy for uterine cervical adeno/adenosquamous carcinoma.
CONCLUSION: CIRT can induce PD-L1 expression in UCAA and we propose that PD-L1 expression after starting CIRT may become as a predictive prognostic marker in CIRT for UCAA. PMID: 31912675 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - January 10, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research