Dietary inflammatory index and risk of gynecological cancers: a systematic review and meta-analysis of observational studies.
Authors: Liu ZY, Gao XP, Zhu S, Liu YH, Wang LJ, Jing CX, Zeng FF Abstract OBJECTIVE: There has been growing body of literatures showing that chronic inflammation might play an important role in cancer development. This meta-analysis aimed to assess the association between the dietary inflammation index (DII) score and gynecological cancers. METHODS: A systematic search of PubMed, EMBASE and Web of Science up until October 20, 2018 was carried out to retrieve all related cohort and case-control studies. The summary risk assessments were pooled using random-effects models. The dose-response relationship was esti...
Source: Journal of Gynecologic Oncology - March 21, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

A multi-institutional analysis of sequential versus 'sandwich' adjuvant chemotherapy and radiotherapy for stage IIIC endometrial carcinoma.
CONCLUSION: Postoperative adjuvant ChT and RT for stage IIIC EC patients, either given sequentially or sandwiched, offers excellent clinical efficacy and acceptably low toxicity. Our data support the superiority of the sandwich regimen compared to the sequential strategy in stage IIIC EC patients for OS. PMID: 30887753 [PubMed - in process] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - March 21, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

PCR-reverse dot blot human papillomavirus genotyping as a primary screening test for cervical cancer in a hospital-based cohort.
Authors: Kang Y, Sun P, Mao X, Dong B, Ruan G, Chen L Abstract OBJECTIVE: To evaluate the polymerase chain reaction (PCR)-reverse-dot-blot (RDB) human papillomavirus (HPV) genotyping test as a feasible assay for the cervical cancer primary screening. METHODS: In a hospital-based cohort, a total of 21,568 women were voluntarily enrolled from March 2009 to November 2016 for evaluating the 3 current cervical cancer screening strategies: co-test, cytology primary and high-risk HPV (HR-HPV) primary by using PCR-RDB HPV genotyping and liquid-based cytology (thinprep cytologic test [TCT]). Women with HR-HPV infection ...
Source: Journal of Gynecologic Oncology - March 21, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Prospective study of the efficacy and utility of TP53 mutations in circulating tumor DNA as a non-invasive biomarker of treatment response monitoring in patients with high-grade serous ovarian carcinoma.
Authors: Kim YM, Lee SW, Lee YJ, Lee HY, Lee JE, Choi EK Abstract OBJECTIVE: Somatic TP53 mutation (TP53mut) is a characteristic finding in high-grade serous ovarian cancer (HGSOC). The aim of this study was to assess the clinical efficacy and utility of TP53mut circulating tumor DNA (ctDNA) monitoring as a biomarker for managing HGSOC. METHODS: TP53muts were evaluated in patients who received primary treatment for suspected ovarian cancer at Asan Medical Center. In patients diagnosed with HGSOC and with TP53mut, ctDNA, cancer antigen 125 (CA 125), and computed tomography were followed up according to the treat...
Source: Journal of Gynecologic Oncology - March 21, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Perioperative morbidity of radical trachelectomy with lymphadenectomy in early-stage cervical cancer: a French prospective multicentric cohort.
CONCLUSION: RT has few severe postoperative complications and appears as a safe alternative to spare fertility of young patients. To guarantee best surgical outcomes, patients should be referred to expert center. PMID: 30887756 [PubMed - in process] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - March 21, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Sentinel lymph node mapping in endometrial and cervical cancer: a survey of practices and attitudes in gynecologic oncologists.
CONCLUSION: The SLNM is utilized frequently among gynecologic oncologists for EC and CC staging. Common reasons for non-uptake include uncertainty of current data, lack of training and technology. Concerns exist regarding impact of SLNM in fellowship training of LND. PMID: 30887757 [PubMed - in process] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - March 21, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Incidence and costs of cervical intraepithelial neoplasia in the Korean population.
Authors: Chang HK, Seo SS, Myong JP, Yu YL, Byun SW Abstract OBJECTIVE: The purpose of this study was to assess the incidence rate of cervical intraepithelial neoplasia (CIN) and cervical cancer, and their costs according to age. METHODS: We collected data on annual incidence and medical costs of CIN and cervical cancer from 2010 until the end of 2014 from the Health Insurance Review and Assessment (HIRA) service. The CIN was classified into CIN3 (high-grade) requiring conization and CIN1/2 (low-grade) requiring observation. RESULTS: Incidence rates of CIN3 and cervical cancer are reducing over time, wherea...
Source: Journal of Gynecologic Oncology - March 21, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Preoperative chemoradiation followed by hysterectomy for cervical cancer: patterns of care and survival in a large, hospital database.
CONCLUSION: We found from this hospital database that completion hysterectomy is used infrequently and did not result in a significant survival difference when accounting for other factors. PMID: 30887759 [PubMed - in process] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - March 21, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

A randomized trial comparing limited-excision conisation to Large Loop Excision of the Transformation Zone (LLETZ) in cervical dysplasia patients.
Authors: Kolben TM, Etzel LT, Bergauer F, Hagemann I, Hillemanns P, Repper M, Kaufmann AM, Sotlar K, Kolben T, Helms HJ, Gallwas J, Mahner S, Dannecker C Abstract OBJECTIVE: To show noninferiority of a limited-excision (resection of the dysplastic lesion only) vs. classical Large Loop Excision of the Transformation Zone (LLETZ). METHODS: In this prospective, randomized, multicenter trial, women with human papillomavirus (HPV) positive cervical intraepithelial neoplasia grade 3 were randomized into two groups (1:1). Primary outcome was the rate of negative HPV tests after 6 months, secondary outcomes included co...
Source: Journal of Gynecologic Oncology - March 21, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Survival outcomes of adjuvant radiotherapy and chemotherapy in women with stage I serous papillary and clear cell carcinoma of the endometrium: a Korean multicenter study.
CONCLUSION: Our findings showed similar survival outcomes for adjuvant radiotherapy and chemotherapy in stage I UPSC and CCC of the endometrium. Further large study with analysis stratified by MI or LVSI is required. PMID: 30887761 [PubMed - in process] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - March 21, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Reproductive counseling and pregnancy outcomes after radical trachelectomy for early stage cervical cancer.
CONCLUSION: A significant proportion of women with early stage cervical cancer do not receive adequate reproductive counseling before RT, and many women undergoing RT experience complications that can negatively impact their fertility. We recommend a preoperative consultation with a reproductive endocrinologist for all patients considering RT. PMID: 30887762 [PubMed - in process] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - March 21, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Immunotherapy in endometrial cancer: new scenarios on the horizon.
Authors: Di Tucci C, Capone C, Galati G, Iacobelli V, Schiavi MC, Di Donato V, Muzii L, Panici PB Abstract This extensive review summarizes clinical evidence on immunotherapy and targeted therapy currently available for endometrial cancer (EC) and reports the results of the clinical trials and ongoing studies. The research was carried out collecting preclinical and clinical findings using keywords such as immune environment, tumor infiltrating lymphocytes, programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) expression, immune checkpoint inhibitors, anti-PD-1/PD-L1 antibodies and others' on PubMed. Finally, ...
Source: Journal of Gynecologic Oncology - March 21, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Combined estrogen-progestin pill is a safe and effective option for endometrial hyperplasia without atypia: a three-year single center experience.
CONCLUSION: For the first time we demonstrate that OCP is an effective therapy for non-atypical EH and is associated with higher remission rate compared with oral progestin. Reproductive outcomes are reassuring and comparable between the two groups. PMID: 30887764 [PubMed - in process] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - March 21, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Risk of cervical dysplasia among human papillomavirus-infected women in Korea: a multicenter prospective study.
Authors: Park Y, Kim TJ, Hwang CS, Cho CH, Jeong DH, Seong SJ, Lee JK, Hur S, Kee MK, Seong J, Ki M Abstract OBJECTIVE: Human papillomavirus (HPV) infection is the most important risk factor for cervical cancer, which progresses from precursor lesions with no symptom if left untreated. We compared the risk of cervical dysplasia among HPV-positive Korean women based on HPV types and infection patterns. METHODS: We observed participants of a 5-year multicenter prospective cohort study, comprising HPV-positive women with either atypical squamous cells of undetermined significance or low-grade squamous intraepithel...
Source: Journal of Gynecologic Oncology - March 21, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Does the adoption of sentinel node mapping allow to design a new trial testing the value of retroperitoneal staging in endometrial cancer?
Authors: Bogani G, Raspagliesi F PMID: 30887766 [PubMed - in process] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - March 21, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Adjuvant hysterectomy in patients with locally advanced cervical cancer treated with concurrent chemoradiotherapy.
Authors: Shim SH PMID: 30887767 [PubMed - in process] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - March 21, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Feasibility and outcome of total laparoscopic radical hysterectomy with no-look no-touch technique for FIGO IB1 cervical cancer.
The objective of the study was to examine survival related to minimally-invasive RH with a "no-look no-touch" technique for clinical stage IB1 cervical cancer. METHODS: This retrospective study compared patients who underwent total laparoscopic radical hysterectomy (TLRH) with no-look no-touch technique (n=80) to those who underwent an abdominal radical hysterectomy (ARH; n=83) for stage IB1 (≤4 cm) cervical cancer. TLRH with no-look no-touch technique incorporates 4 specific measures to prevent tumor spillage: 1) creation of a vaginal cuff, 2) avoidance of a uterine manipulator, 3) minimal handling of the...
Source: Journal of Gynecologic Oncology - March 21, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Improving pregnancy outcomes in fertility preserved cervical cancer patients: big challenge after radical trachelectomy.
Authors: Li J PMID: 30887769 [PubMed - in process] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - March 21, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Major clinical research advances in gynecologic cancer in 2018.
Authors: Kim M, Suh DH, Lee KH, Eom KY, Toftdahl NG, Mirza MR, Kim JW Abstract Nineteen topics were selected as major clinical research advances in gynecologic oncology in 2018. For cervical cancer, the importance of human papillomavirus (HPV) testing alone as primary cervical cancer screening method and negative survival impact of minimally invasive surgery in early-stage cervical cancer were addressed. For ovarian cancer, cost-effectiveness of genetic testing to prevent cancer, use of analgesics and oral pill to reduce cancer risk, efficacy of secondary cytoreductive surgery and hyperthermic intraperitoneal chemo...
Source: Journal of Gynecologic Oncology - February 27, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Additional benefit of minimally invasive surgery to improve functional outcomes after radical hysterectomy.
Authors: Park JY PMID: 30806046 [PubMed - in process] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - February 27, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Psychiatric comorbidities among endometrial cancer survivors in South Korea: a nationwide population-based, longitudinal study.
CONCLUSION: Mental disorders showed different prevalence patterns among endometrial cancer survivors depending on patient age and the nature of the disease. Intensive and personalized management of distress is necessary for endometrial cancer survivors. PMID: 30740948 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - February 12, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

The management of hydatidiform mole with lung nodule: a retrospective analysis in 53 patients.
CONCLUSIONS: Our results suggest that lung nodule alone is not an adequate indication of chemotherapy in molar pregnancy. hCG surveillance is safe for patients with lung nodule, especially with single nodule, as long as their hCG levels do not meet International Federation of Gynecology and Obstetrics diagnostic criteria for GTN. PMID: 30740949 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - February 12, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Cost effectiveness analysis of HPV primary screening and dual stain cytology triage compared with cervical cytology.
CONCLUSIONS: Our model results suggest that screening by use of HPV genotyping test as a primary screening test combined with dual stain cytology as the triage of HPV positive women in Thai population 30-65 years old is expected to be more cost-effective than conventional Pap cytology. PMID: 30740950 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - February 12, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Role of adjuvant chemotherapy in the management of non-granulosa cell ovarian sex cord-stromal tumors.
CONCLUSIONS: Adjuvant CT was associated with improved survival for patients with advanced stage non-GC SCSTs. No clear benefit was found for those with early stage disease. PMID: 30740951 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - February 12, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Treatment modalities for recurrent high-grade vaginal intraepithelial neoplasia.
CONCLUSIONS: Patients with recurrent high-grade vaginal intra-epithelial neoplasia are at high risk of developing new recurrences. Our data underline that the choice of primary treatment might have an impact of further outcomes. PMID: 30740952 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - February 12, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

How to evaluate the adequacy of staging for nodal-negative epithelial ovarian cancer? Use of nodal staging score.
CONCLUSION: NSS, as an auxiliary tool, not only could assist the International Federation of Gynecology and Obstetrics staging more precisely, but also would provide a statistical basis for postoperative evaluation for further clinical decision-making. PMID: 30740953 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - February 12, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Trends in incidence of uterine cancer in Songkhla, Southern Thailand.
CONCLUSION: The incidence of uterine cancer is increasing. The policy, which promotes protective factors and control risk factors, would decrease incidence of endometrial cancer, and other estrogen dependent cancers additional to chronic diseases from the cardiovascular system. PMID: 30740954 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - February 12, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Laparoscopic surgery for low, intermediate and high-risk endometrial cancer.
CONCLUSION: The results of our study support the well-known positive aspects of LS as well as safe and effective use in cases of intermediate and high-risk EC. PMID: 30740955 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - February 12, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Bowel resection rate but not bowel related morbidity is decreased after interval debulking surgery compared to primary surgery in patents with stage IIIC-IV ovarian cancer.
Authors: Tozzi R, Casarin J, Baysal A, Valenti G, Kilic Y, Majd HS, Morotti M Abstract OBJECTIVE: To assess the morbidity associate with rectosigmoid resection (RSR) in patients with stage IIIC-IV ovarian cancer (OC) undergone primary debulking surgery (PDS) vs. interval debulking surgery (IDS) after neoadjuvant chemotherapy (NACT). METHODS: From the Oxford Advanced OC database, we retrieved all patients who underwent surgery between January 2009 and July 2016 and included all patients who underwent RSR. We compared the rates of overall related and not-related morbidity and bowel diversion in patients undergone...
Source: Journal of Gynecologic Oncology - February 12, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Olaparib induced senescence under P16 or P53 dependent manner in ovarian cancer.
This study intends to explore the role of olaparib in the regulation of senescence in ovarian cancer cells. METHODS: The effects of olaparib on the senescence of ovarian cancer cells were detected by using the senescence-associated β-galactosidase (SA-β-Gal) and senescence-associated heterochromatin aggregation (SAHF). Quantitative real-time polymerase chain reaction was used to analyze the senescence-associated secretory phenotype (SASP). Cell cycle and apoptosis were detected by flow cytometry. The effect of olaparib on tumor growth was analyzed in a nude mouse xenograft transplantation model. RESULTS: ...
Source: Journal of Gynecologic Oncology - February 12, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Minimally invasive surgery improves short-term outcomes of nerve-sparing radical hysterectomy in patients with cervical cancer: a propensity-matched analysis with open abdominal surgery.
Authors: Bogani G, Rossetti D, Ditto A, Martinelli F, Chiappa V, Leone C, Leone Roberti Maggiore U, Lorusso D, Raspagliesi F Abstract OBJECTIVES: Nerve-sparing radical hysterectomy has been implemented in order to reduce pelvic floor dysfunctions in women undergoing radical surgery for cervical cancer. Here, we aimed to investigate if the adoption of laparoscopic surgery impacts on patients' outcomes. METHODS: Data of consecutive patients affected by cervical cancer who had laparoscopic nerve-sparing radical hysterectomy were matched 1:1 with an historical cohort of patients undergoing open procedure. A propens...
Source: Journal of Gynecologic Oncology - February 12, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Clinical guideline for 9-valent HPV vaccine: Korean Society of Gynecologic Oncology Guideline.
Authors: Min KJ, Kwon SH, Kim K, Kim S, Kim HJ, Seong SJ, Song YJ, Lee KH, Lee SW, Lee JW, Chang SJ, Ju W, Kim YT, Lee JK Abstract In 2016, 9-valent human papillomavirus (HPV) vaccine has been newly introduced in Korea, thus the need to develop recommendations for the vaccine has raised. Until we decide to develop a guideline, no further studies on the bi-valent or quadri-valent HPV vaccine have been announced. We searched and reviewed the literatures focused on the efficacy of 9-valent HPV vaccine, the ideal age of 3-dose schedule vaccination, the efficacy of 9-valent HPV vaccine in middle-aged women, the efficacy...
Source: Journal of Gynecologic Oncology - February 12, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Trends of uterine cancer incidence: a projection from the past to the future.
Authors: Tangjitgamol S PMID: 30740960 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - February 12, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Asian Society of Gynecologic Oncology International Workshop 2018.
Authors: Kong TW, Ryu HS, Kim SC, Enomoto T, Li J, Kim KH, Shim SH, Wang PH, Therasakvichya S, Kobayashi Y, Lee M, Shi T, Lee SW, Mikami M, Nagase S, Lim MC, Wang J, Wilailak S, Kim SW, Hong SH, Tan DS, Mandai M, Chang SJ, Huang RYJ, Ushijima K, Lee JY, Chen X, Ochiai K, Lee TS, Yang B, Kalam F, Lv Q, Ahmad MF, Yaznil MR, Modi KB, Manopunya M, Jeong DH, Lertkhachonsuk AA, Chung HH, Watari H, Jeon S Abstract The Asian Society of Gynecologic Oncology International Workshop 2018 on gynecologic oncology was held in the Ajou University Hospital, Suwon, Korea on the 24th to 25th August 2018. The workshop was an opportuni...
Source: Journal of Gynecologic Oncology - February 12, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Multidisciplinary perspectives on newly revised 2018 FIGO staging of cancer of the cervix uteri.
Authors: Berek JS, Matsuo K, Grubbs BH, Gaffney DK, Lee SI, Kilcoyne A, Cheon GJ, Yoo CW, Li L, Shao Y, Chen T, Kim M, Mikami M PMID: 30740962 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - February 12, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Rethinking the next step after unexpected results associated with minimally invasive radical hysterectomy for early cervical cancer.
Authors: Pyeon SY, Hur YJ, Lee JM PMID: 30740963 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - February 12, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Six months response rate of combined oral medroxyprogesterone/levonorgestrel-intrauterine system for early-stage endometrial cancer in young women: a Korean Gynecologic-Oncology Group Study.
CONCLUSION: Combined oral MPA/LNG-IUS treatment for EC showed 37.1% of CR rate at 6 months. Considering the short treatment periods, CR rate may be much higher if the treatment continued to 9 or 12 months. So, this treatment is still a viable treatment option for young women of early-stage EC. Endometrial aspiration biopsy with the LNG-IUS in place is less accurate than D&C for follow-up evaluation of patients undergoing this treatment. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT01594879. PMID: 30740964 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - February 12, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

The 4th European Society for Medical Oncology Asia Congress: bridging ultimate cancer care with real-world practice for the Asian practitioner in gynecological cancers.
Authors: Ngoi NY, Tan DS PMID: 30740965 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - February 12, 2019 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Incidence of cervical, endometrial, and ovarian cancer in Korea during 1999-2015.
CONCLUSION: Overall, ASRs and APCs for the three major gynecological cancers are decreasing, with a recent reduction in the width of the change. However, there has been a progressive increase in the incidence of endometrial and ovarian cancers. PMID: 30574686 [PubMed - in process] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - December 24, 2018 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Significance of elevated SCC-Ag level on tumor recurrence and patient survival in patients with squamous-cell carcinoma of uterine cervix following definitive chemoradiotherapy: a multi-institutional analysis.
Authors: Choi KH, Lee SW, Yu M, Jeong S, Lee JW, Lee JH Abstract OBJECTIVE: There is no definitive guideline for the significance and cut-off value of squamous-cell carcinoma antigen (SCC-Ag) in cervical cancer. Thus, we analyzed the significance and optimal cut-off value of SCC-Ag for predicting tumor recurrence and patient survival in squamous-cell carcinoma of uterine cervix. METHODS: From January 2010 to October 2016, we enrolled 304 cervical cancer patients with squamous-cell carcinoma staging International Federation of Gynecology and Obstetrics (FIGO) Ib-IVa and treated with definitive chemoradiotherapy ...
Source: Journal of Gynecologic Oncology - November 29, 2018 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Factors influencing decision-making around opportunistic salpingectomy: a nationwide survey.
CONCLUSION: In this study we evaluated the current practice regarding the opportunistic salpingectomy in the Netherlands and identified influencing factors on different levels to raise awareness and attribute to development of a targeted implementation strategy, on both national and international level. PMID: 30479086 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - November 29, 2018 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Incorporation of paclitaxel-based hyperthermic intraperitoneal chemotherapy in patients with advanced-stage ovarian cancer treated with neoadjuvant chemotherapy followed by interval debulking surgery: a protocol-based pilot study.
CONCLUSIONS: According to our study protocol, IDS followed by paclitaxel-based HIPEC as a first-line treatment appears to be feasible and safe for the treatment of advanced-stage ovarian cancer. Further evaluations of this procedure are required to assess its survival benefits. PMID: 30479087 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - November 29, 2018 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

The detrimental effect of adopting interval debulking surgery in advanced stage low-grade serous ovarian cancer.
CONCLUSION: LGSC is at high risk of early recurrence. However, owing to the indolent nature of the disease, the majority of patients are long-term survivors. Further prospective studies and innovative treatment modalities are warranted to improve patients care. PMID: 30479088 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - November 29, 2018 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Association of pretreatment thrombocytosis with prognosis in ovarian cancer: a systematic review and meta-analysis.
CONCLUSION: Pre-treatment thrombocytosis might be taken as an independent prognostic indicator for patients with OC. PMID: 30479089 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - November 29, 2018 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

The age-adjusted Charlson comorbidity index as a predictor of survival in surgically treated vulvar cancer patients.
Authors: Di Donato V, Page Z, Bracchi C, Tomao F, Musella A, Perniola G, Panici PB Abstract OBJECTIVE: To evaluate the impact of age-adjusted Charlson comorbidity index (ACCI) in predicting disease-free survival (DFS), overall survival (OS), and cancer-specific survival (CSS) among surgically treated patients with vulvar carcinoma. The secondary aim is to evaluate its impact as a predictor of the pattern of recurrence. METHODS: We retrospectively evaluated data of patients that underwent surgical treatment for vulvar cancer from 1998 to 2016. ACCI at the time of primary surgery was evaluated and patients were c...
Source: Journal of Gynecologic Oncology - November 29, 2018 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Prognostic factors of synchronous endometrial and ovarian endometrioid carcinoma.
CONCLUSION: SEO-EC patients with tumors localized to the uterine body and adnexa lesions had a low risk for recurrence and may not require adjuvant therapy. SEO-EC may have prognostic factors different from those of endometrial and ovarian cancer. PMID: 30479091 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - November 29, 2018 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

A novel prediction score for predicting the baseline risk of recurrence of stage I-II endometrial carcinoma.
Authors: Takahashi K, Yunokawa M, Sasada S, Takehara Y, Miyasaka N, Kato T, Tamura K Abstract OBJECTIVE: To develop and validate a 3-year recurrence prediction score (RPS) system for predicting the baseline risk of recurrence of stage I-II endometrial carcinoma. METHODS: We reviewed 427 patients with International Federation of Gynecology and Obstetrics staging I-II endometrial carcinoma underwent surgery without any adjuvant therapy from 2005 to 2013. The patients were divided into 2 groups: the test cohort (n=251) comprising those who underwent surgery in odd-numbered years, and the validation cohort (n=176) ...
Source: Journal of Gynecologic Oncology - November 29, 2018 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Efficacy and dosimetry analysis of image-guided radioactive 125I seed implantation as salvage treatment for pelvic recurrent cervical cancer after external beam radiotherapy.
CONCLUSION: IGRIS implantation could be a safe and effective salvage treatment for PRCC after EBRT, which could markedly release the pain. Recurrence site, tumor volume and dose were the main factors affected efficacy. Compared with central recurrence, it was more suitable for patients with pelvic wall recurrent cervical cancer after EBRT. PMID: 30479093 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - November 29, 2018 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Current state and outlook for drug repositioning anticipated in the field of ovarian cancer.
Authors: Kobayashi Y, Banno K, Kunitomi H, Tominaga E, Aoki D Abstract Ovarian cancer is the seventh most common cancer and the eighth most common cause of cancer mortality in women. Although standard chemotherapy is the established treatment for ovarian cancer, the prognosis remains poor, and it is highly anticipated that new drugs will be developed. New drugs, such as humanized anti-vascular endothelial growth factor monoclonal antibodies and poly ADP-ribose polymerase inhibitors, are expected to improve clinical outcomes of ovarian cancer. However, long-term, costly research is required to develop such new drugs...
Source: Journal of Gynecologic Oncology - November 29, 2018 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Optimal cutoff age for predicting prognosis associated with serous epithelial ovarian cancer: what is the best age cutoff?
CONCLUSION: An age of 66 years is the best cutoff to define elderly age in serous EOC patients considering the geriatric assessment, and this information can be used in the administration of individualized therapies in elderly EOC patients. PMID: 30479095 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - November 29, 2018 Category: OBGYN Tags: J Gynecol Oncol Source Type: research