Huangkui Lianchang Decoction Ameliorates DSS-Induced Ulcerative Colitis in Mice by Inhibiting the NF-kappaB Signaling Pathway.
Conclusion: HLD can alleviate the inflammation caused by ulcerative colitis. In particular, high doses of HLD can significantly alleviate intestinal inflammation and have comparable efficacy to Mesalazine. We propose that the anti-inflammatory activity of HLD on DSS-induced colitis in mice may involve the inhibition of the NF-κB pathway. PMID: 31093294 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - May 18, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Identification of Chinese Herbal Compounds with Potential as JAK3 Inhibitors.
In conclusion, our work discovered 3 potential natural inhibitors of JAK3 kinase and could provide new possibilities and stimulate new insights for the treatment of JAK3-targeted diseases. PMID: 31093295 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - May 18, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

The Use of Medicinal Plants in the Riverside Community of the Mazag ão River in the Brazilian Amazon, Amapá, Brazil: Ethnobotanical and Ethnopharmacological Studies.
This study aimed to perform an ethnopharmacological survey of medicinal plants used by the riparian community of the floodplains of the Mazagão River, in the State of Amapá. In this study, we chose semistructured interviews with socioeconomic, ethnopharmacological, and ethnobotanical aims. The collection of medicinal plants occurred during guided tours. The Use Value (UV), Informant Consensus Factor (ICF), Correction Factor (CF), and Fidelity level (FL) were calculated. There were 130 species of medicinal plants, distributed in 116 genera and 57 families; Fabaceae (16), Lamiaceae (14), Euphorbiaceae (7), and ...
Source: Evidence-based Complementary and Alternative Medicine - May 18, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Traditional Chinese Medicine Yimucao Injection Combined with Western Medicine for Preventing Postpartum Hemorrhage after Cesarean Section: A Systematic Review and Meta-Analysis.
Authors: Chen S, Xie B, Tian H, Ding S, Lu C Abstract Objective: Yimucao injection combined with several contraction uterus drugs is in use for preventing postpartum hemorrhage after cesarean section. The present study is a meta-analysis comparing the efficacy and safety of these drugs. Methods: PubMed, Cochrane Library, Embase, the China National Knowledge Infrastructure (CNKI), the Chinese Biomedical Database (CBM), VIP, and Wanfang database were searched until June 2018. We selected RCTs of Yimucao injection combined with western medicine for preventing postpartum hemorrhage and study quality was assessed us...
Source: Evidence-based Complementary and Alternative Medicine - May 18, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

An External CAM Therapy (Tian Jiu) versus Placebo in Treatment of Allergic Rhinitis: A Pilot Single-Blinded, Three-Arm, Randomized Controlled Study.
Authors: Dai L, Zhong LLD, Kun W, Lam WC, Yang Z, Huang T, Mu H, Bian ZX Abstract Allergic rhinitis (AR) is one of the common allergic diseases in clinical practice and significantly impairs the quality of life (QoL) of patients. The conventional treatments are not satisfactory because of various reasons. Tian Jiu (TJ) therapy is a characteristic external intervention of complementary and alternative medicine (CAM) and has been widely utilized in the management of AR. However, the evidences resulted from current studies were generally poor due to high risk of bias. Therefore, we conducted this rigorous designed, si...
Source: Evidence-based Complementary and Alternative Medicine - May 18, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Effect of Short-Course Oral Ciprofloxacin on Isoflavone Pharmacokinetics following Soy Milk Ingestion in Healthy Postmenopausal Women.
The objective of this one-group pre-post treatment study was to determine the effect of short-course oral ciprofloxacin on isoflavone pharmacokinetics in healthy postmenopausal women. Eleven postmenopausal subjects were assigned to consume a single oral dose of 375 mL UHT soy milk (SOY phase). Blood samples were collected immediately before soy milk ingestion and at specific times for 32 hours after soy milk ingestion. Following a washout period of at least seven days, subjects were assigned to take 250 mg oral ciprofloxacin after breakfast and dinner for three days, followed by a single oral dose of 375 mL UHT soy ...
Source: Evidence-based Complementary and Alternative Medicine - May 18, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Cytostatic and Antiproliferative Activities of F5 Fraction of Crinum amabile Leaf Chloroform Extract Showed Its Potential as Cancer Chemotherapeutic Agent.
In conclusion, F5 fraction from C. amabile leaf CE was able to exhibit cytostatic effect through antiproliferation activity rather than induction of cell apoptosis and therefore has the potential to be further investigated as an anticancer agent. PMID: 31097973 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - May 18, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Thirteen-Week Oral Toxicity Study of HVC1 in Rats.
Authors: Lee K, Choi HY Abstract Studies on the safety of herbal medicine are essential for the development of new drugs. The aim of this study was to evaluate the no-observed-adverse-effect-level (NOAEL) of HVC1 (Gamisamhwangsasim-tang, a 30% ethanol extract of a mixture of Pruni Cortex, Scutellariae Radix, Coptidis Rhizoma, and Rhei Rhizoma) and identify its target organs after oral administration to Sprague-Dawley (SD) rats repeatedly for 13 weeks. Three test groups were treated with HVC1 at a dose of either 500 (low-dose), 1,000 (middle-dose), or 2,000 (high-dose) mg/kg/day. Another group received high-dose HVC...
Source: Evidence-based Complementary and Alternative Medicine - May 18, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

The Antimicrobial and Wound Healing Potential of Opuntia ficus indica L. inermis Extracted Oil from Tunisia.
Conclusion: OFI extracted oil has in vitro antimicrobial/fungal properties and in vivo wound healing activity. It seems to be efficient in the treatment of cutaneous infections and the promoting of the scarring process. PMID: 31097975 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - May 18, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Modulation of Diacylglycerol-Induced Melanogenesis in Human Melanoma and Primary Melanocytes: Role of Stress Chaperone Mortalin.
Authors: Wadhwa R, Li L, Singh R, Wang J, Gao R, Nigam N, Forestier S, Ando N, Kaul SC Abstract Skin color/pigmentation is regulated through melanogenesis process in specialized melanin-producing cells, melanocytes, involving multiple signaling pathways. It is highly influenced by intrinsic and extrinsic factors such as oxidative, ultraviolet radiations and other environmental stress conditions. Besides determining the color, it governs response and tolerance of skin to a variety of environmental stresses and pathological conditions including photodamage, hyperpigmentation, and skin cancer. Depigmenting reagents ha...
Source: Evidence-based Complementary and Alternative Medicine - May 18, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Protective Effect of the Total Triterpenes of Euscaphis konishii Hayata Pericarp on Bacillus Calmette-Gu érin Plus Lipopolysaccharide-Induced Liver Injury.
Conclusion: The pericarp of E. konishii may be further considered as a potent natural food for liver disease treatment. PMID: 31080480 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - May 14, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Potential of Regular Consumption of Cameroonian Neem (Azadirachta indica L.) Oil for Prevention of the 7,12-Dimethylbenz(a)anthracene-Induced Breast Cancer in High-Fat/Sucrose-Fed Wistar Rats.
Authors: Zingue S, Kamga Silihe K, Fouba Bourfane I, Boukar A, Tueche AB, Njuh AN, Njamen D Abstract Neem (Azadirachta indica) is a tree from the Meliaceae family native to India, where it is considered as one of the most important plants worldwide. The anticancer effects of neem oil on breast cancer cells have been recently reported; however, its in vivo effects have not been studied. This prompted us to investigate the protective effects of neem oil on 7,12-dimethylbenz(a)anthracene (DMBA)-induced breast cancer in high-fat/sucrose-fed Wistar rats. Juvenile female Wistar rats were treated either with neem oil at a...
Source: Evidence-based Complementary and Alternative Medicine - May 14, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Hirsutella sinensis Treatment Shows Protective Effects on Renal Injury and Metabolic Modulation in db/db Mice.
In this study, db/db mice were used as the DN model, and the renal protective effect was evaluated after oral administration of HS for 6 and 12 weeks. Plasma, urine, and kidney samples were collected, and biochemical indicator measurements, pathological analysis, and metabolomics studies were performed. Biochemical assays showed that HS reduced the levels of fasting blood glucose (FBG), urinary albumin/creatinine ratio (ACR), and N-acetyl-beta-D-glucosaminidase (NAG) and increased the creatinine clearance (Ccr). HS alleviated glomerular and tubular glycogen accumulation and fibrosis and normalized the disordered ultrastruc...
Source: Evidence-based Complementary and Alternative Medicine - May 14, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

A Mathematical Model to Study the Mechanical Information Induced by Lifting-Thrusting Needle.
This study proposes a preliminary comprehension of the mechanical response around the needle during the acupuncture process. PMID: 31080483 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - May 14, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Two-Week Repeated Oral Dose Toxicity Study of Mantidis Ootheca Water Extract in C57BL/6 Mice.
Conclusion. Based on these findings, we concluded that treatment of mice with the water extract of MO did not result in significant toxicity and, therefore, it could be considered safe for further pharmacological studies. PMID: 31080484 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - May 14, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Phytochemical and Safety Evaluation of Hydroethanolic Leaf Extract of Tecoma stans (L.) Juss. ex Kunth.
This study focused on the phytoconstituents screening, antioxidant activity, and heavy metal analysis as well as the acute and subchronic toxicity of the hydroethanolic leaf extract (TSE) using standard methods. The presence of flavonoids, alkaloids, cardiac glycosides, saponins, coumarins, and terpenoids in the raw leaf of the plant was observed while the hydroethanolic extract contained coumarins, saponins, cardiac glycosides, and flavonoids. The DPPH percentage scavenging activity of the crude extract was 64.32% while the fractions, ethyl acetate (55.26%), methanol (60.72%), and hydro (36.97%.), gave varying activities....
Source: Evidence-based Complementary and Alternative Medicine - May 14, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Safety and Efficacy of Tianfoshen Oral Liquid in Non-Small Cell Lung Cancer Patients as an Adjuvant Therapy.
Authors: Zhao L, Wang J, Li H, Che J, Ma N, Cao B Abstract Ethnopharmacological Relevance: As an important Chinese herb injection, Tianfoshen (TFS) oral liquid is widely used in Chinese non-small cell lung cancer (NSCLC) patients. Aim of the Study: To evaluate the efficacy and safety of Tianfoshen (TFS) oral liquid plus chemotherapy in Chinese NSCLC patients with Qi and Yin deficiency syndrome, an observational study was conducted in Beijing Friendship Hospital between August 2012 and July 2016. Patients, enrolled in this study, were diagnosed with NSCLC and were treated with Cisplatin in combination with Pacli...
Source: Evidence-based Complementary and Alternative Medicine - May 11, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Ethnopharmacological Inspections of Organic Extract of Oroxylum indicum in Rat Models: A Promising Natural Gift.
This study remarked that O. indicum has anti-inflammatory, antiulcer, antidiabetic, and antidyslipidemic potentials but has no ameliorative effect on liver enzyme. PMID: 31073315 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - May 11, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Corrigendum to "Systematic Understanding of the Mechanism of Baicalin against Ischemic Stroke through a Network Pharmacology Approach".
Corrigendum to "Systematic Understanding of the Mechanism of Baicalin against Ischemic Stroke through a Network Pharmacology Approach". Evid Based Complement Alternat Med. 2019;2019:4520704 Authors: Xu T, Ma C, Fan S, Deng N, Lian Y, Tan L, Du W, Zhang S, Liu S, Ren B, Li Z, Wang Q, Wang X, Cheng F Abstract [This corrects the article DOI: 10.1155/2018/2582843.]. PMID: 31073316 [PubMed - in process] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - May 11, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Corrigendum to "Effectiveness and Safety of Acupotomy for Lumbar Disc Herniation: A Randomized, Assessor-Blinded, Controlled Pilot Study".
Corrigendum to "Effectiveness and Safety of Acupotomy for Lumbar Disc Herniation: A Randomized, Assessor-Blinded, Controlled Pilot Study". Evid Based Complement Alternat Med. 2019;2019:4538692 Authors: Kim SY, Kim E, Kwon O, Han CH, Kim YI Abstract [This corrects the article DOI: 10.1155/2018/5871657.]. PMID: 31073317 [PubMed - in process] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - May 11, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Effectiveness and Safety of Oral Cordyceps sinensis on Stable COPD of GOLD Stages 2-3: Systematic Review and Meta-Analysis.
Authors: Yu X, Mao Y, Shergis JL, Coyle ME, Wu L, Chen Y, Zhang AL, Lin L, Xue CC, Xu Y Abstract Cordyceps sinensis (CS) is a complementary medicine used for Chronic Obstructive Pulmonary Disease (COPD) of Global Initiative for Chronic Obstructive Lung Disease (GOLD) stages 2-3. Many randomized controlled trials have been conducted to evaluate the effect of CS alone or in combination with other herbs on stable COPD. To provide a synthesis of the evidence, we searched nine major electronic databases for randomized controlled trials on CS published before 21st December 2016. Fifteen interventional studies, including ...
Source: Evidence-based Complementary and Alternative Medicine - May 11, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Cecropia pachystachya Leaves Present Potential to Be Used as New Ingredient for Antiaging Dermocosmetics.
This study aims to report, for the first time, the antiaging potential of the hydroethanolic (HE) and the ethanolic (EE) extracts obtained from the leaves of C. pachystachya using different in vitro assays. Both HE and EE presented relevant antioxidant capacity in different models, including phosphomolybdenum, 1,1-diphenyl-2-picryl-hydrazyl (DPPH), carotene/linoleic acid bleaching, and thiobarbituric acid reactive substances (TBARS) assays. Their ability to prevent the production of advanced glycation end products (AGEs) was also evaluated, and both extracts showed important activity, especially HE. The extracts also stimu...
Source: Evidence-based Complementary and Alternative Medicine - May 11, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Effects of Phytoestrogen Supplement on Quality of Life of Postmenopausal Women: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
This study evaluated the effects of phytoestrogen supplement on quality of life for postmenopausal women. Methods: We conducted a systematic review and meta-analysis of randomized controlled trials on the effects of phytoestrogen supplements on the quality of life of postmenopausal women. We searched PubMed, MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials on March 31, 2018, for relevant randomized controlled trials. Two authors independently selected studies, assessed risk of bias, and extracted data. Disagreement was resolved through discussion with a third author. Results: We involved 10 a...
Source: Evidence-based Complementary and Alternative Medicine - May 8, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Panax ginseng Inhibits Metabolism of Diester Alkaloids by Downregulating CYP3A4 Enzyme Activity via the Pregnane X Receptor.
Authors: Yang L, Wang Y, Xu H, Huang G, Zhang Z, Ma Z, Gao Y Abstract To investigate the effects of P. ginseng C.A. Mey (P. ginseng) on the metabolism of diester alkaloids and explore the potential mechanism. P. ginseng was administered orally to rats for 7 days, after which liver microsome samples were prepared and then incubated with diester alkaloids. Ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry was used to determinate the concentration of diester alkaloids to calculate the clearance rate. The cocktail method was used to evaluate the effects of oral administration of P...
Source: Evidence-based Complementary and Alternative Medicine - May 8, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Ethnobotanical Study of Medicinal Plants Used in Central Macedonia, Greece.
Authors: Tsioutsiou EE, Giordani P, Hanlidou E, Biagi M, De Feo V, Cornara L Abstract This work provides the ethnobotanical data concerning the traditional use of medicinal plants in Macedonia region (Northern Greece), which has, up to now, been poorly investigated. The aim of the present study was to collect, analyze, and evaluate information on the use of medicinal plants among different population groups living in Central Macedonia. The study was carried out in the area of two small cities, Edessa and Naoussa, and nearby villages. The ethnobotanical data were gathered through extensive and semistructured intervi...
Source: Evidence-based Complementary and Alternative Medicine - May 8, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

WS-5 Extract of Curcuma longa, Chaenomeles sinensis, and Zingiber officinale Contains Anti-AChE Compounds and Improves β-Amyloid-Induced Memory Impairment in Mice.
The objective of this study was to assess the therapeutic effect of WS-5 ethanol extract in vitro and in vivo against Aβ-induced AD in mice and to identify the extract's active constituents. In the present study, WS-5 exerted a significant inhibitory effect on acetylcholinesterase (AChE). Analysis by transmission electron microscopy (TEM) revealed that WS-5 prevented Aβ oligomerization via inhibition of Aβ 1-42 aggregation. Evaluation of antioxidant activities using 1, 1-diphenyl-2-picrylhydrazyl (DPPH) demonstrated that WS-5 possessed a high antioxidant activity, which was confirmed by measuring the total a...
Source: Evidence-based Complementary and Alternative Medicine - May 8, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

The Effects of Cordyceps sinensis (Berk.) Sacc. and Gymnema inodorum (Lour.) Decne. Extracts on Adipogenesis and Lipase Activity In Vitro.
This study aimed to investigate the effects of Cordyceps sinensis extract (CSE) and Gymnema inodorum extract (GIE), used alone and combined, on antiadipogenesis in 3T3-L1 cells. Oil Red O staining was used to examine the effects of these extracts on inhibition of intracellular lipid accumulation in 3T3-L1 adipocytes and on lipid droplet morphology. Fourier transform-infrared (FTIR) microspectroscopy was used to examine biomolecular changes in 3T3-L1 adipocytes. The pancreatic lipase assay was used to evaluate the inhibitory effects of CSE and GIE on pancreatic lipase activity. Taken together, the results indicated that CSE...
Source: Evidence-based Complementary and Alternative Medicine - May 8, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

A Review of Oenanthe javanica (Blume) DC. as Traditional Medicinal Plant and Its Therapeutic Potential.
Authors: Lu CL, Li XF Abstract Oenanthe javanica, popularly known as water dropwort, has long been used in various ethnomedical systems in Asia, especially in China, Korean, and Japan, for treating various chronic and acute hepatitis, jaundice, alcohol hangovers, abdominal pain, and inflammatory conditions. The present review aims to provide a general report of the available literature on traditional uses, phytochemical, pharmacological, nutritional, and toxicological data related to the O. javanica as a potential source of new compounds with biological activities. Considering phytochemical studies, coumarins, flav...
Source: Evidence-based Complementary and Alternative Medicine - May 8, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Albizia julibrissin Ameliorates Memory Loss Induced by Insomnia in Drosophila.
Authors: Chang JS, Liu HP, Cheng J, Chen CJ, Hwang SL, Tseng CC, Hsu LF, Lin WY Abstract In clinical practice in Taiwan, Albizia julibrissin is the most prescribed Chinese herbal medicine for insomnia. Short-term insomnia and hypnotic use both attenuate cognitive functions, especially learning memory. In previous studies, A. julibrissin exhibits sedative activity, antidepressant-like effects, and protection of learning and memory against amnesia. However, whether A. julibrissin ameliorates memory loss caused by short-term sleep deprivation is not clear. We utilized the sleep-deprived Drosophila model and olfactory ...
Source: Evidence-based Complementary and Alternative Medicine - May 8, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Antineuroinflammatory and Neuroprotective Effects of Gyejibokryeong-Hwan in Lipopolysaccharide-Stimulated BV2 Microglia.
Authors: Park BK, Kim YH, Kim YR, Choi JJ, Yang C, Jang IS, Lee MY Abstract Microglia, the central nervous system's innate immune cells, mediate neuroinflammation and are implicated in a variety of neuropathologies. The present study investigated the antineuroinflammatory and neuroprotective effects of Gyejibokryeong-hwan (GBH), a traditional Korean medicine, in lipopolysaccharide- (LPS-) stimulated murine BV2 microglia. BV2 cells were pretreated with GBH, fluoxetine (FXT), or amitriptyline (AMT) for 1 h and then stimulated with LPS (100 ng/mL). The expression levels of nitric oxide (NO), cytokines, and chemokines ...
Source: Evidence-based Complementary and Alternative Medicine - May 8, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Phellodendri Cortex: A Phytochemical, Pharmacological, and Pharmacokinetic Review.
Conclusions: The compounds of the crude bark of PC and its subspecies have showcased a wide range of pharmacological effects. Pharmacological efficacies of PC are supported by its diverse class of alkaloid, limonoid, phenolic acid, quinic acid, lignan, and flavonoid. Obacunone and obaculactone could be the bioactive compounds for atopic dermatitis management. PC and its subspecies are generally safe to use but extra care is required for certain conditions and group of people. PMID: 31057654 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - May 8, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Efficiency of Sophora flavescens-Fructus Ligustri Lucidi Drug Pairs in the Treatment of Liver Fibrosis Based on the Response Surface Method.
Authors: Chu S, Zhang H, Ding L Abstract The pairing of Sophora flavescens and Fructus Ligustri lucidi is taken from Shi Jinmo Medicine. The idea behind this pairing was inspired by the similarity in pharmacological effects of the two herbal drugs, both of which are known to be effective in the treatment and protection against liver fibrosis. To quantitatively study the extent of the interaction between these drugs and the effect of pairing on the treatment of liver fibrosis, an animal model of liver fibrosis mice was established by intraperitoneal injection of low-dose carbon tetrachloride. The drugs were then adm...
Source: Evidence-based Complementary and Alternative Medicine - May 8, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Nanobubbles Water Curcumin Extract Reduces Injury Risks on Drop Jumps in Women: A Pilot Study.
Conclusion: We demonstrate that 4-week-NCE supplementation can also be used in explosiveness exercise for better physiological adaptation. Thus, NCE has potential for use with nutrient supplements toward a variety of benefits for athletics. PMID: 31057656 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - May 8, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Melittin Inhibits Hypoxia-Induced Vasculogenic Mimicry Formation and Epithelial-Mesenchymal Transition through Suppression of HIF-1 α/Akt Pathway in Liver Cancer.
In conclusion, this study indicates melittin may inhibit hypoxia-induced VM formation and EMT in liver cancer through inhibiting HIF-1α/Akt pathway. PMID: 31057657 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - May 8, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Danshen Formulae for Cancer: A Systematic Review and Meta-Analysis of High-Quality Randomized Controlled Trials.
Conclusion: The current research results showed that Danshen formulae combined with chemotherapy for cancer treatment was better than conventional drug treatment plan alone. PMID: 31061667 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - May 8, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Benefits of Hesperidin for Cutaneous Functions.
Authors: Man MQ, Yang B, Elias PM Abstract Hesperidin is a bioflavonoid, with high concentration in citrus fruits. In addition to its well-known benefits for cardiovascular function, type II diabetes, and anti-inflammation, recent studies have demonstrated multiple benefits of hesperidin for cutaneous functions, including wound healing, UV protection, anti-inflammation, antimicrobial, antiskin cancer, and skin lightening. In addition, hesperidin enhances epidermal permeability barrier homeostasis in both normal young and aged skin. The mechanisms by which hesperidin benefits cutaneous functions are attributable to ...
Source: Evidence-based Complementary and Alternative Medicine - May 8, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

The Effect of Moxibustion Stimulation on Local and Distal Skin Temperature in Healthy Subjects.
Authors: Li Y, Sun C, Kuang J, Ji C, Wu J Abstract The aim of this study is to investigate the response of local and distal skin temperature to moxibustion stimulation (MS) and explore the effects of MS on sympathetic nerve activity. The distal skin temperatures of fingertips, as an indicator for sympathetic reflex response, were recorded using infrared camera during resting period (10 min), MS period (10 min), and natural cooling period (15 min), respectively. The MS without ash cleaning (AC) was applied to acupoints Quze (PC3) (Group I) and Lao Gong (PC8) (Group II), respectively. In Group III, the MS with the op...
Source: Evidence-based Complementary and Alternative Medicine - May 8, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Yiqi Yangyin Huoxue Method in Treating Diabetic Retinopathy: A Systematic Review and Meta-Analysis.
Authors: Ou C, Yang YJ, Peng QH Abstract Objective: To evaluate the efficacy of Yiqi Yangyin Huoxue method in the treatment of diabetic retinopathy (DR) with meta-analysis. Method: A randomized controlled trial of Yiqi Yangyin Huoxue method in the treatment of diabetic retinopathy in PubMed, Medline, Cochrane Library, Weipu Journal, China Knowledge Network, and Wanfang database was conducted. Two reviewers independently extracted data and methodological quality assessment. Data analysis was performed using Rev Man 5.3 software for statistical analysis. Results: A total of 10 randomized controlled trials, in...
Source: Evidence-based Complementary and Alternative Medicine - May 8, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Evaluation of In Vitro Antioxidant and Antidiabetic Activities of Aristolochia longa Extracts.
Authors: El Omari N, Sayah K, Fettach S, El Blidi O, Bouyahya A, Faouzi MEA, Kamal R, Barkiyou M Abstract Oxidative stress plays a major role in diabetic physiopathology; hence, the interest of using natural antioxidants as therapeutic tools exists. The aim of this study was the evaluation of in vitro antioxidant activity and inhibitory potential of organic extracts from Aristolochia longa roots against key enzymes linked to hyperglycemia. Antioxidant activity was performed using 2,2'-diphenyl-1-picrylhydrazyl (DPPH) and 2,2-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radicals and ferric reducing/antiox...
Source: Evidence-based Complementary and Alternative Medicine - May 8, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Gut Microbiota-Mediated NLRP12 Expression Drives the Attenuation of Dextran Sulphate Sodium-Induced Ulcerative Colitis by Qingchang Wenzhong Decoction.
In conclusion, our study supports the potential of QCWZD administration as a beneficial therapeutic strategy for UC. PMID: 31061672 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - May 8, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

BRM270 Inhibits the Proliferation of CD44 Positive Pancreatic Ductal Adenocarcinoma Cells via Downregulation of Sonic Hedgehog Signaling.
In this study, we investigated the effect of BRM270 on the isolated CD44 positive pancreatic ductal adenocarcinoma cells (CD44+ PDAC). Results showed that CD44 positive cells undergo apoptosis induced by BRM270. Moreover, BRM270 also inhibits stemness and metastasis traits in CD44+ PDAC via Sonic hedgehog signaling pathway and SALL4 expression. In vivo study indicated that tumor growth derived from CD44+ PDAC was suppressed as daily uptake by BRM270 5 mg/kg. These data suggest the alternative approach in antipancreatic tumorigenesis via herbal plants extract and selectively targeting CD44+ PDAC cells in tumor. PMID: 31...
Source: Evidence-based Complementary and Alternative Medicine - May 4, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Compound Phyllanthus urinaria L Inhibits HBV-Related HCC through HBx-SHH Pathway Axis Inactivation.
Authors: Li Y, Jiang M, Li M, Chen Y, Wei C, Peng L, Liu X, Liu Z, Tong G, Zhou D, He J Abstract Compound Phyllanthus urinaria L (CP) is a traditional formula widely used in clinical practice for hepatocellular carcinoma (HCC), especially HBV-related HCC. HBx, HBV X gene encoded X protein, has positive correlation with the abnormal SHH pathway in HBV-related HCC. So, we predicted that CP has the capability of anti-HBV-related HCC maybe via inactivating the HBx-Hedgehog pathway axis. HepG2-HBx cells, HBx overexpression, were treated with CP (70μg/ml and 35 μg/ml, respectively) for 48 hours and the mice ...
Source: Evidence-based Complementary and Alternative Medicine - April 27, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Tian Wang Bu Xin Dan for Insomnia: A Systematic Review of Efficacy and Safety.
This study evaluated the efficacy and safety of TWBXD for insomnia. Methods: We searched seven main databases including PubMed, EMBASE, Cochrane Central Register of Controlled Trials, Chinese Biomedicine Database (CBM), China National Knowledge Infrastructure (CNKI), Chinese Scientific Journals Database (VIP), and Wan-fang. We identified randomized-controlled trials (RCTs) for insomnia treatment involving TWBXD, TWBXD combined with conventional Western medicine, and conventional Western medicine from their inception to May 2018. The quality of literature was evaluated by Cochrane assessing tool to reduce the risk of bi...
Source: Evidence-based Complementary and Alternative Medicine - April 27, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Effective Treatment of Bovine Mastitis with Intramammary Infusion of Angelica dahurica and Rheum officinale Extracts.
In this study, we used Angelica dahurica and Rheum officinale extracts (designated as Yi-Xiong-Tang, YXT) for mastitis treatment. California mastitis test (CMT) was performed and 67 mastitis udder quarters were identified among 179 lactating dairy cows. These 67 mastitis udder quarters were subjected to treatments by intramammary infusion of YXT twice a day for three consecutive days. The mastitis indicators including clots, lactate dehydrogenase (LDH), TNF-α, IL-6, IL-8, and total viable count of bacteria (TVC) in milk were examined before and after the YXT treatment to evaluate its effectiveness. Levels of mastitis...
Source: Evidence-based Complementary and Alternative Medicine - April 27, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Effects of Huanglian-Renshen-Decoction, a Fixed Mixture of Traditional Chinese Medicine, on the Improvement of Glucose Metabolism by Maintenance of Pancreatic β Cell Identity in db/db Mice.
Effects of Huanglian-Renshen-Decoction, a Fixed Mixture of Traditional Chinese Medicine, on the Improvement of Glucose Metabolism by Maintenance of Pancreatic β Cell Identity in db/db Mice. Evid Based Complement Alternat Med. 2019;2019:1232913 Authors: Yuan F, Wang D, Ma L, Qin X, Gong J, Hu M, Su H, Dong H, Lu F Abstract Huanglian-Renshen-Decoction (HRD) is widely used to treat type 2 diabetes mellitus (T2DM) in China. However, the underlying mechanism is unclear. We aimed to investigate the mechanism by which HRD regulates the glucose level. Forty 7-8-week-old db/db (BSK) mice were randomly assi...
Source: Evidence-based Complementary and Alternative Medicine - April 25, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Mongolian Medicine RuXian-I Treatment of Estrogen-Induced Mammary Gland Hyperplasia in Rats Related to TCTP Regulating Apoptosis.
Authors: Zhang JF, Liu J, Gong GH, Zhang B, Wei CX Abstract Mongolian medicine RuXian-I is composed of 30 Mongolian herbs, which is a traditional Mongolian recipe for clinical treatment of breast "Qi Su Bu Ri Le Du Sen" disease (hyperplasia of mammary glands, HMG). Based on the previous study, this dissertation further explores the therapeutic mechanism of RuXian-I on estrogen-induced HMG in rats. RuXian-I had no effect on the body weight and food intake of HMG rats and had no toxic effects on the five organs (heart, lung, spleen, and kidney). RuXian-I reduced the diameter and height of nipple, organ inde...
Source: Evidence-based Complementary and Alternative Medicine - April 25, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Network Pharmacology-Based Study on the Mechanism of Bushen-Jianpi Decoction in Liver Cancer Treatment.
Authors: Wu R, Li XY, Wang WH, Cai FF, Chen XL, Yang MD, Pan QS, Chen QL, Zhou RY, Su SB Abstract To investigate the mechanism of a Bushen-Jianpi decoction (BSJPD) in liver cancer (LC) treatment, we analyzed clinical therapy data, conducted network pharmacology analysis, and performed pharmacological experimental verification in vitro and in vivo. The univariate analysis of clinical therapy showed that the BSJPD was protective factor (p
Source: Evidence-based Complementary and Alternative Medicine - April 25, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Preventive Effect of the Herbal Preparation, HemoHIM, on Cisplatin-Induced Immune Suppression.
In this study, to examine the effect on the restoration of immune cells and balance in the immune system, we utilized a cisplatin-induced immunosuppression mouse model. Mice were injected intraperitoneally with cisplatin, an immunosuppressive anticancer, and then received oral doses of 100, 250, and 500 mg/kg of HemoHIM for 14 days. The HemoHIM prevented the cisplatin-induced loss of body and organ weight. In terms of innate immunity, natural killer (NK) cell activity and phagocytosis increased in the HemoHIM group compared to the cisplatin control group. The HemoHIM group also showed a significantly higher expression of T...
Source: Evidence-based Complementary and Alternative Medicine - April 25, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Acupuncture to Promote Recovery of Disorder of Consciousness after Traumatic Brain Injury: A Systematic Review and Meta-Analysis.
Authors: Tan L, Zeng L, Wang N, Deng M, Chen Y, Ma T, Zhang L, Xu Z Abstract Traumatic brain injury (TBI) has become an economic and social burden for patients and their families. While acupuncture is an effective tool for promoting recovery of disorder of consciousness (DOC) following TBI, there have been no comprehensive meta-analyses and/or systematic reviews addressing this topic. The present systematic review and meta-analysis aimed to assess the therapeutic efficacy of acupuncture for DOC after TBI. All randomized controlled trials (RCTs) incorporating acupuncture, or acupuncture combined with other intervent...
Source: Evidence-based Complementary and Alternative Medicine - April 25, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Comparisons of the Effectiveness and Safety of Tuina, Acupuncture, Traction, and Chinese Herbs for Lumbar Disc Herniation: A Systematic Review and Network Meta-Analysis.
Conclusions: In the treatment of lumbar disc herniation, Tuina and acupuncture were superior to traction or Chinese herbs, and the effectiveness of traction was the worst. However, considering the limitations of this review, more high-quality trials, especially those comparing Chinese herbs with the other three interventions, should be carried out in the future to further confirm the current findings. PMID: 31015852 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - April 25, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research