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Chinese Herbal Medicine as an Adjunctive Therapy Ameliorated the Incidence of Chronic Hepatitis in Patients with Breast Cancer: A Nationwide Population-Based Cohort Study.
In conclusion, our study provided information that western medicine therapy combined with CHM as an adjuvant modality may have a significant impact on liver protection in patients with breast cancer. PMID: 29234362 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - December 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Shenfu Injection Adjunct with Platinum-Based Chemotherapy for the Treatment of Advanced Non-Small-Cell Lung Cancer: A Meta-Analysis and Systematic Review.
Authors: Cao A, He H, Jing M, Yu B, Zhou X Abstract Platinum-based chemotherapy is one of the standard treatments for non-small-cell lung cancer (NSCLC), while its high toxicity and limited clinical effects raise big concerns. Shenfu injection (SFI) has been commonly used as an adjutant chemotherapy drug for NSCLC in China. We ascertained the beneficial and adverse effects of SFI in combination with platinum-based chemotherapy for advanced NSCLC by using meta-analysis methods. The randomized controlled trials (RCTs) involving advanced NSCLC treatment with SFI plus platinum-based chemotherapy versus chemotherapy alo...
Source: Evidence-based Complementary and Alternative Medicine - December 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

EGHB010, a Standardized Extract of Paeoniae Radix and Glycyrrhizae Radix, Inhibits VEGF-Induced Tube Formation In Vitro and Retinal Vascular Leakage and Choroidal Neovascularization In Vivo.
In this study, we aimed to evaluate the effect of EGHB010 on retinal vascular leakage and laser-induced CNV in a rat model. Vascular endothelial growth factor- (VEGF-) induced tube formation was assayed in human retinal microvascular endothelial cells. Intravitreal VEGF-induced blood-retinal barrier breakdown was assayed in Sprague-Dawley rats. Experimental CNV was induced by laser photocoagulation in Brown Norway rats. EGHB010 (50 and 100 mg/kg/day) was administered orally for 10 days after laser photocoagulation. Choroidal flat mounts were prepared to measure the lesion size of CNV. Incubation of retinal vascular ...
Source: Evidence-based Complementary and Alternative Medicine - December 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Ethnopharmacological Uses, Phytochemistry, and Pharmacological Properties of Croton macrostachyus Hochst. Ex Delile: A Comprehensive Review.
Authors: Maroyi A Abstract Croton macrostachyus is widely used as herbal medicine by the indigenous people of tropical Africa. The potential of C. macrostachyus as herbal medicine, the phytochemistry, and pharmacological properties of its parts used as herbal medicines are reviewed. The extensive literature survey revealed that C. macrostachyus is traditionally used to treat or manage at least 81 human and animal diseases and ailments. The species is used as herbal medicine for diseases and ailments such as abdominal pains, cancer, gastrointestinal disorders, malaria, pneumonia, sexually transmitted infections, ski...
Source: Evidence-based Complementary and Alternative Medicine - December 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Antioxidant and Anti-Inflammatory Effects of Herbal Formula SC-E3 in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages.
In this study, we sought to determine the effects of SC-E3 on free radical generation and inflammatory response in lipopolysaccharide- (LPS-) treated RAW 264.7 macrophages and the molecular mechanism involved. The ethanol extract of SC-E3 showed good free radical scavenging activity and inhibited LPS-induced reactive oxygen species generation. SC-E3 significantly inhibited the production of the LPS-induced inflammatory mediators, nitric oxide and prostaglandin E2, by suppressing the expressions of inducible nitric oxide synthase and cyclooxygenase-2, respectively. SC-E3 also prevented the secretion of the proinflammatory c...
Source: Evidence-based Complementary and Alternative Medicine - December 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

The Use of Herbal Remedies among Mothers of Young Children Living in the Central Appalachian Region.
Conclusion: Herbal remedies are commonly used among women living in the Central Appalachian Region, a region with lower education and income level. Therefore, public health interventions about the types, safety, and efficacy of herbal remedies may improve health within this population. PMID: 29234367 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - December 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Mechanisms of P-Glycoprotein Modulation by Semen Strychni Combined with Radix Paeoniae Alba.
Authors: Liu LL, Guan YM, Lu XP, Liang XL, Chen LH Abstract Semen Strychni has been extensively used as a Chinese herb, but its therapeutic window is narrowed by the strong toxicity of the compound, which limits its effectiveness. Radix Paeoniae Alba has been reported to reduce the toxic effects and increase the therapeutic effects of Semen Strychni, but the underlying mechanism remains unknown. This research aimed to explore the mechanism through which P-glycoprotein (P-gp) is modulated by Semen Strychni combined with Radix Paeoniae Alba in vitro. An MTT assay was used to study cytotoxicity in an MDCK-MDR1 cell mo...
Source: Evidence-based Complementary and Alternative Medicine - December 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Bufei Yishen Granules Combined with Acupoint Sticking Therapy Suppress Inflammation in Chronic Obstructive Pulmonary Disease Rats: Via JNK/p38 Signaling Pathway.
In conclusion, the favorable effect of Bufei Yishen granules combined with Shu-Fei Tie may be due to decreased inflammation through regulation of the JNK/p38 signaling pathways. PMID: 29234369 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - December 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Electroacupuncture Improves Gastric Emptying in Critically Ill Neurosurgical Patients: A Pilot Study.
Authors: Kao ML, Chen YL, Lee SC, Huang SY, Lin PY Abstract Objective: To compare the efficacy of combined electroacupuncture and metoclopramide treatment with that of metoclopramide only in improving gastric emptying in critically ill neurosurgical patients. Methods: In this prospective case-control pilot study, a total of 16 adult critically ill mechanically ventilated patients who were treated in the surgical intensive care unit were enrolled. Electrical stimulation was applied to 4 pairs of points (maximum intensity
Source: Evidence-based Complementary and Alternative Medicine - December 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Correlation between Traditional Chinese Medicine Constitution and Dyslipidemia: A Systematic Review and Meta-Analysis.
Conclusion: This study provides evidence for the prevention and treatment of dyslipidemia in TCM. However, most of the studies included are of moderate quality; more high quality, multicenter, large-sample studies are expected to provide higher level evidence. PMID: 29234371 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - December 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Hawthorn Leaf Flavonoids Protect against Diabetes-Induced Cardiomyopathy in Rats via PKC- α Signaling Pathway.
Conclusions: HLF has a protective effect against diabetic cardiomyopathy in rats. The mechanism may be involved in reducing oxidative stress and inflammation via inactivation of the PKC-α signaling pathway. PMID: 29234372 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - December 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Corrigendum to "Effect of Taichi Softball on Function-Related Outcomes in Older Adults: A Randomized Control Trial".
Corrigendum to "Effect of Taichi Softball on Function-Related Outcomes in Older Adults: A Randomized Control Trial". Evid Based Complement Alternat Med. 2017;2017:2186987 Authors: Luo L, Zou L, Fang Q, Wang H, Liu Y, Tian Z, Han Y Abstract [This corrects the article DOI: 10.1155/2017/4585424.]. PMID: 29234373 [PubMed - in process] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - December 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

The Role of MAPK and Dopaminergic Synapse Signaling Pathways in Antidepressant Effect of Electroacupuncture Pretreatment in Chronic Restraint Stress Rats.
Authors: Yang X, Guo Z, Lu J, Zhao B, Fei Y, Li J, Jiang H, Sun L, Wang Y, Sun Y, Bao T Abstract Acupuncture has demonstrated the function in ameliorating depressive-like behaviors via modulating PKA/CREB signaling pathway. To further confirm the antidepressant mechanism of EA on the mitogen-activated protein kinase (MAPK) and dopaminergic synapse signaling pathways, 4 target proteins were detected based on our previous iTRAQ analysis. Rats were randomly divided into control group, model group, and electroacupuncture (EA) group. Except for the control group, all rats were subjected to 28 days of chronic restraint s...
Source: Evidence-based Complementary and Alternative Medicine - December 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Kidney-Replenishing Herb Induces SOCS-3 Expression via ERK/MAPK Pathway and Improves Growth of the First-Trimester Human Trophoblast Cells.
Authors: Xing CY, Zhang DX, Gui SQ, Tao MF Abstract Kidney-replenishing herb is a traditional medicine formula in China which has been widely used for clinical treatment of recurrent miscarriage. Our previous study showed that Kidney-replenishing herb could promote proliferation and inhibit apoptosis of the human first-trimester trophoblasts. In the present study, we further explored the potential mechanism and signal pathway of Kidney-replenishing herb on human trophoblast cells. Our research showed that Kidney-replenishing herb stimulated proliferation and reduced apoptosis of human trophoblast cells in vitro, an...
Source: Evidence-based Complementary and Alternative Medicine - December 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Roles of Nitric Oxide and Prostaglandins in the Sustained Antihypertensive Effects of Acanthospermum hispidum DC. on Ovariectomized Rats with Renovascular Hypertension.
Authors: Palozi RAC, Schaedler MI, Tirloni CAS, Silva AO, Lívero FADR, Souza RIC, Dos Santos AC, Prando TBL, de Souza LM, Gasparotto Junior A Abstract Although Acanthospermum hispidum is used in Brazilian folk medicine as an antihypertensive, no study evaluated its effects on a renovascular hypertension and ovariectomy model. So, this study investigated the mechanisms involved in the antihypertensive effects of an ethanol-soluble fraction obtained from A. hispidum (ESAH) using two-kidney-one-clip hypertension in ovariectomized rats (2K1C plus OVT). ESAH was orally administered at doses of 30, 100, and 300&th...
Source: Evidence-based Complementary and Alternative Medicine - December 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

The Ethanol Extract of Licorice (Glycyrrhiza uralensis) Protects against Triptolide-Induced Oxidative Stress through Activation of Nrf2.
Authors: Cao LJ, Hou ZY, Li HD, Zhang BK, Fang PF, Xiang DX, Li ZH, Gong H, Deng Y, Ma YX, Tang HB, Yan M Abstract To investigate the potential role of nuclear factor erythroid 2-related factor 2 (Nrf2) in licorice ethanol extract (LEE) against triptolide- (TP-) induced hepatotoxicity, HepG2 cells were exposed to LEE (30, 60, and 90 mg·L-1) for 12 h and then treated with TP (50 nM) for 24 h. Besides, an acute liver injury model was established in ICR mice by a single dose of TP (1.0 mg·kg-1, i.p.). Relevant oxidant and antioxidant mediators were analyzed. TP led to a...
Source: Evidence-based Complementary and Alternative Medicine - December 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Antibiofilm and Anti-Inflammatory Activities of Houttuynia cordata Decoction for Oral Care.
Authors: Sekita Y, Murakami K, Yumoto H, Hirao K, Amoh T, Fujiwara N, Hirota K, Fujii H, Matsuo T, Miyake Y, Kashiwada Y Abstract Dental biofilms that form in the oral cavity play a critical role in the pathogenesis of several infectious oral diseases, including dental caries, periodontal disease, and oral candidiasis. Houttuynia cordata (HC, Saururaceae) is a widely used traditional medicine, for both internal and external application. A decoction of dried HC leaves (dHC) has long been consumed as a health-promoting herbal tea in Japan. We have recently reported that a water solution of HC poultice ethanol extract...
Source: Evidence-based Complementary and Alternative Medicine - December 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

The Instrument for Measuring the Implementation Situation of Traditional Chinese Medicine Guideline: Evaluation and Application.
Authors: Li H, Wang Y, Chen Y, Wang X, Lu C, Deng J Abstract Clinical practice guidelines play an important role in reducing the variations in clinical practices and improving the quality of care. To assess the real effect, measuring its implementation situation is needed. The implementation situation can be reflected by testing the consistency between the actual clinical practice and the guideline. We constructed an instrument to measure the implementation situation of Traditional Chinese Medicine (TCM) guideline through consistency testing. The main objectives of our study were to validate the instrument and eval...
Source: Evidence-based Complementary and Alternative Medicine - December 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Compression of the Fourth Ventricle Using a Craniosacral Osteopathic Technique: A Systematic Review of the Clinical Evidence.
Authors: Żurowska A, Malak R, Kołcz-Trzęsicka A, Samborski W, Paprocka-Borowicz M Abstract Compression of the fourth ventricle (CV4) is a well-known osteopathic procedure, utilized by osteopaths, osteopathic physicians, craniosacral therapists, physical therapists, and manual therapists as part of their healthcare practice based on some evidence suggesting impact on nervous system functions. The main objective of the study was to identify randomized controlled trials (RCTs) assessing the clinical benefits of CV4 and to show the evidence supporting clinical prescriptions, guides, and advice in treating. A compute...
Source: Evidence-based Complementary and Alternative Medicine - December 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Antihyperglycemic, Antidiabetic, and Antioxidant Effects of Garcinia pedunculata in Rats.
Authors: Ali MY, Paul S, Tanvir EM, Hossen MS, Rumpa NN, Saha M, Bhoumik NC, Aminul Islam M, Hossain MS, Alam N, Gan SH, Khalil MI Abstract The antihyperglycemic, antidiabetic, and antioxidant potentials of the methanolic extract of Garcinia pedunculata (GP) fruit in rats were investigated. The acute antihyperglycemic effect of different doses of GP was studied in normal male Wistar rats. Diabetes was induced by streptozotocin (STZ) injection in another cohort of male Wistar rats and they showed significantly higher blood glucose and glycated hemoglobin (HbA1c) levels, altered lipid profiles, and lower insulin leve...
Source: Evidence-based Complementary and Alternative Medicine - December 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Biotechnological and Therapeutic Application of Useful Plants in Endocrinal Disorder.
Authors: Kim NH, Chandra V, Shukla S, Kumar P PMID: 29234382 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - December 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Goreisan Inhibits Upregulation of Aquaporin 4 and Formation of Cerebral Edema in the Rat Model of Juvenile Hypoxic-Ischemic Encephalopathy.
Authors: Yano Y, Yano H, Takahashi H, Yoshimoto K, Tsuda S, Fujiyama K, Izumo-Shimizu Y, Motoie R, Ito M, Tanaka J, Ishii E, Fukuda M Abstract Secondary cerebral edema regulation is of prognostic significance in hypoxic-ischemic encephalopathy (HIE), and aquaporin 4 (AQP4) plays an important role in the pathogenesis of cerebral edema. The traditional Japanese herbal medicine Goreisan relieves brain edema in adults; however, its effect and pharmacological mechanism in children are unknown. We investigated the effects of Goreisan on HIE-associated brain edema and AQP4 expression in a juvenile rat model, established b...
Source: Evidence-based Complementary and Alternative Medicine - December 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Screening of Natural Bioactive Metabolites and Investigation of Antioxidant, Antimicrobial, Antihyperglycemic, Neuropharmacological, and Cytotoxicity Potentials of Litsea polyantha Juss. Ethanolic Root Extract.
This study was designed to identify some bioactive phytochemicals from ethanolic extract of roots of Litsea polyantha and to evaluate some of its pharmacological activities. Phytochemical tests indicated the presence of reducing sugar, combined reducing sugar, tannins, flavonoids, alkaloids, terpenoids, and phenol. In the antioxidant assay using 2-diphenyl-1-picryl-hydrazyl (DPPH) free radical scavenging method, the IC50 value was found to be 82.31 μg/mL. Total content of phenolic compounds, flavonoid, and tannin was found to be 152.69 mg GAE/gm, 85.60 mg QE/gm, and 77.22 mg GAE/gm of dry ext...
Source: Evidence-based Complementary and Alternative Medicine - December 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

The Immediate Analgesic Effect of Acupuncture for Pain: A Systematic Review and Meta-Analysis.
Authors: Xiang A, Cheng K, Shen X, Xu P, Liu S Abstract Although acupuncture is gaining popularity for the treatment of nonspecific pain, the immediate analgesic effect of acupuncture has never been reviewed. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) on disease-related pain to critically evaluate the immediate effect of acupuncture for pain relief. The PubMed and Cochrane Central Register of Controlled Trials databases as well as three Chinese databases including the China National Knowledge Infrastructure (CNKI), Wanfang, and VIP platforms were searched through Novem...
Source: Evidence-based Complementary and Alternative Medicine - December 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Neuroprotective Effect of Modified Xijiao Dihuang Decoction against Oxygen-Glucose Deprivation and Reoxygenation-Induced Injury in PC12 Cells: Involvement of TLR4-MyD88/NF- κB Signaling Pathway.
Neuroprotective Effect of Modified Xijiao Dihuang Decoction against Oxygen-Glucose Deprivation and Reoxygenation-Induced Injury in PC12 Cells: Involvement of TLR4-MyD88/NF-κB Signaling Pathway. Evid Based Complement Alternat Med. 2017;2017:3848595 Authors: Zhang X, Fei X, Tao W, Li J, Shen H, Wang X, Liu H, Xu Y Abstract Modified Xijiao Dihuang (XJDH) decoction has been shown to exert powerful neuroprotective properties in clinical ischemic stroke treatment. It consists of 4 Chinese herbs: Buffalo Horn, Paeonia suffruticosa Andrews, Rehmannia glutinosa (Gaertn.) DC, and Paeonia lactiflora Pall. I...
Source: Evidence-based Complementary and Alternative Medicine - December 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Antioxidant Activity of a Geopropolis from Northeast Brazil: Chemical Characterization and Likely Botanical Origin.
Authors: Ferreira JM, Fernandes-Silva CC, Salatino A, Message D, Negri G Abstract Geopropolis is a product containing wax, plant resin, and soil particles. It is elaborated by stingless bees of tribe Meliponini. Methanol extracts of sample of geopropolis produced by Scaptotrigona postica ("mandaguari") in the state of Rio Grande do Norte (RN, northeast Brazil) were analyzed for the determination of standard parameters (total phenols, total flavonoids, and radical scavenging activity) and chemical characterization by HPLC-DAD-MS/MS analysis. The sample analyzed has high contents of total phenols and flavon...
Source: Evidence-based Complementary and Alternative Medicine - December 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

The Effects of Aqueous Extract from Nardostachys chinensis Batalin on Blood Pressure and Cardiac Hypertrophy in Two-Kidney One-Clip Hypertensive Rats.
Conclusion: Our data demonstrate that NCBAE has an antihypertensive property and protective effect on 2K1C-induced cardiac hypertrophy especially at the dose of 630 mg·kg-1·d-1. PMID: 29234388 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - December 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Rapid Screening of Chemical Constituents in Rhizoma Anemarrhenae by UPLC-Q-TOF/MS Combined with Data Postprocessing Techniques.
In this study, UPLC-Q-TOF/MS was used in combination with data postprocessing techniques, including characteristic fragments filter and neutral loss filter, to rapidly classify and identify the five types of substances in Rhizoma Anemarrhenae. On the basis of numerous literature reviews and according to the corresponding characteristic fragments produced by different types of compounds in combination with neutral loss filtering, we summarized the fragmentation patterns of the main five types of compounds and successfully screened and identified 32 chemical constituents in Rhizoma Anemarrhenae. The components included 18 st...
Source: Evidence-based Complementary and Alternative Medicine - December 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Astragaloside IV Ameliorates Airway Inflammation in an Established Murine Model of Asthma by Inhibiting the mTORC1 Signaling Pathway.
Authors: Jin H, Wang L, Li B, Cai C, Ye J, Xia J, Ma S Abstract Astragaloside IV (AS-IV), a main active constituent of Astragalus membranaceus, has been confirmed to have antiasthmatic effects. However, it remained unclear whether the beneficial effects of AS-IV on asthma were attributed to the mTOR inhibition; this issue was the focus of the present work. BALB/c mice were sensitized and challenged with ovalbumin followed with 3 weeks of rest/recovery and then reexposure to ovalbumin. AS-IV was administrated during the time of rest and reexposure. The characteristic features of allergic asthma, including airway hyp...
Source: Evidence-based Complementary and Alternative Medicine - December 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Antidiarrheal Activity of Dissotis multiflora (Sm) Triana (Melastomataceae) Leaf Extract in Wistar Rats and Subacute Toxicity Evaluation.
Authors: Afagnigni AD, Nyegue MA, Ndoye Foe CF, Njankouo Ndam Y, Njayou FN, Fonkoua MC, Etoa FX Abstract The present work was undertaken to evaluate antidiarrheal activity of ethanolic leaf extract of Dissotis multiflora (Sm) Triana (D. multiflora) on Shigella flexneri-induced diarrhea in Wistar rats and its subacute toxicity. Diarrhea was induced by oral administration of 1.2 × 109 cells/mL S. flexneri to rats. Antidiarrheal activity was investigated in rats with the doses of 111.42 mg/kg, 222.84 mg/kg, and 445.68 mg/kg. The level of biochemical parameters was assessed and organs histolo...
Source: Evidence-based Complementary and Alternative Medicine - December 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

1H NMR-Based Metabonomic Study of Functional Dyspepsia in Stressed Rats Treated with Chinese Medicine Weikangning.
This study may provide new insights into the relationship between FD and psychological stress and assist in research into the metabolic mechanisms involved in Chinese medicine. PMID: 29234392 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - December 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Reduced MLH3 Expression in the Syndrome of Gan-Shen Yin Deficiency in Patients with Different Diseases.
This study aimed to assess the characteristic genes of gan-shen Yin deficiency constitution in different diseases. Fifty primary liver cancer (PLC) patients, 94 hypertension (HBP) patients, and 100 diabetes mellitus (DM) patients were enrolled and classified into gan-shen Yin deficiency group and non-gan-shen Yin deficiency group according to the body constitution questionnaire to assess the clinical manifestation of patients. The mRNA expressions of 17 genes in PLC patients with gan-shen Yin deficiency were different from those without gan-shen Yin deficiency. However, considering all patients with PLC, HBP, and DM, only ...
Source: Evidence-based Complementary and Alternative Medicine - December 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Predictors of Traditional Medical Practices in Illness Behavior in Northwestern Ethiopia: An Integrated Model of Behavioral Prediction Based Logistic Regression Analysis.
This study aimed at investigating traditional medical beliefs and practices in illness behavior as well as predictors of the practices in Gondar city, northwestern Ethiopia, by using the integrated model of behavioral prediction. A cross-sectional quantitative survey was conducted to collect data through interviewer administered structured questionnaires from 496 individuals selected by probability proportional to size sampling technique. Unadjusted bivariate and adjusted multivariate logistic regression analyses were performed, and the results indicated that sociocultural predictors of normative response and attitude as w...
Source: Evidence-based Complementary and Alternative Medicine - December 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

The Effect of Dongeui Qigong for Prehypertension and Mild Essential Hypertension.
This study aimed to assess the effect of qigong on prehypertension and mild hypertension. Participants with prehypertension or mild hypertension were randomized to the Dongeui qigong group or a nontreated control group. In the qigong group, Dongeui qigong was administered 5 times/week for 12 weeks. The control group did not receive any intervention for blood pressure control. Fifty-two participants were included in this study. Even though diastolic blood pressure was significantly reduced in the qigong group after 8 weeks (p = 0.04) compared to baseline, the difference in change in blood pressure between the qigong and con...
Source: Evidence-based Complementary and Alternative Medicine - December 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Analgesic Effect of Moxibustion with Different Temperature on Inflammatory and Neuropathic Pain Mice: A Comparative Study.
Authors: Zhou W, Lei R, Zuo C, Yue Y, Luo Q, Zhang C, Lv P, Tang Y, Yin H, Yu S Abstract The aim of this study was to determine whether variation of temperature during moxibustion would generate division of analgesic effect. The moxibustion with different temperatures (37°C, 42°C, 47°C, and 52°C) was applied to ST36 acupoint for 30 minutes in chronic inflammatory or neuropathic pain mice. The analgesic effect was evaluated by thermal hyperalgesia test in chronic inflammatory pain and by mechanical allodynia in neuropathic pain, respectively. The results indicated that interventions of moxibus...
Source: Evidence-based Complementary and Alternative Medicine - December 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Artemisia iwayomogi plus Curcuma longa Synergistically Ameliorates Nonalcoholic Steatohepatitis in HepG2 Cells.
In conclusion, we found synergic effects of A. iwayomogi and C. longa on NASH, supporting the clinical potential for fatty liver disorders. In addition, modulation of ER stress-relative molecules would be involved in its underlying mechanism. PMID: 29234397 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - December 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Review on Research about Traditional Chinese Medicine in Cancer Stem Cell.
Authors: Wang Y, Feng L, Piao B, Zhang P Abstract Cancer stem cells (CSCs) are small subpopulations of neoplastic cells within a tumor, which have self-renewal and differentiation abilities and could generate new tumors with few cells. Researches have showed that CSCs are considered the most likely reason for cancer recurrence and metastasis. Accumulating evidences have showed that traditional Chinese medicine (TCM) has significant effect on CSCs. It could inhibit the proliferation, self-renew, and multidifferentiation of CSCs. We aimed to summarize the theories of CSCs in TCM, the inhibitory effect, and the pathwa...
Source: Evidence-based Complementary and Alternative Medicine - December 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Antimicrobial Activities and Time-Kill Kinetics of Extracts of Selected Ghanaian Mushrooms.
This study investigated the antimicrobial properties of methanol extracts of Trametes gibbosa, Trametes elegans, Schizophyllum commune, and Volvariella volvacea. Agar well diffusion, broth microdilution, and time-kill kinetic assays were used to determine the antimicrobial activity of the extracts against selected test organisms. Preliminary mycochemical screening revealed the presence of tannins, flavonoids, triterpenoids, anthraquinones, and alkaloids in the extracts. Methanol extracts of T. gibbosa, T. elegans, S. commune, and V. volvacea showed mean zone of growth inhibition of 10.00 ± 0.0 to 21.50 ± 0.84...
Source: Evidence-based Complementary and Alternative Medicine - December 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Effect of Acupotomy on FAK-PI3K Signaling Pathways in KOA Rabbit Articular Cartilages.
Authors: Ma SN, Xie ZG, Guo Y, Yu JN, Lu J, Zhang W, Wang LJ, Xu J, Zhao RL, Zhou S, Guo CQ Abstract Objective: By observing the needle-knife of KOA rabbit morphology, knee joint cartilage p-FAK, p-PI3K, Aggrecan gene, and protein expression, to study the effect of needle-knife to promote cartilage cell synthesis metabolism mechanism. Method: 49 male New Zealand rabbits, randomly divided into normal group (Z), model group (M), model-inhibitors (MP), needle-knife group (D), needle-knife inhibitors group (DP), electroacupuncture group (E), and electroacupuncture inhibitors (EP). RT-PCR and Western Blot were used ...
Source: Evidence-based Complementary and Alternative Medicine - December 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

trans-Cinnamaldehyde Inhibits Microglial Activation and Improves Neuronal Survival against Neuroinflammation in BV2 Microglial Cells with Lipopolysaccharide Stimulation.
Conclusions: Our results suggest that TCA, a natural product, has the potential of being used as a therapeutic agent against neuroinflammation for ameliorating neurodegenerative disorders. PMID: 29234401 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - December 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Extract of Fructus Cannabis Ameliorates Learning and Memory Impairment Induced by D-Galactose in an Aging Rats Model.
Authors: Chen NY, Liu CW, Lin W, Ding Y, Bian ZY, Huang L, Huang H, Yu KH, Chen SB, Sun Y, Wei L, Peng JH, Pan SL Abstract Hempseed (Cannabis sativa L.) has been used as a health food and folk medicine in China for centuries. In the present study, we sought to define the underlying mechanism by which the extract of Fructus Cannabis (EFC) protects against memory impairment induced by D-galactose in rats. To accelerate aging and induce memory impairment in rats, D-galactose (400 mg/kg) was injected intraperitoneally once daily for 14 weeks. EFC (200 and 400 mg/kg) was simultaneously administered intraga...
Source: Evidence-based Complementary and Alternative Medicine - December 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Response Surface Optimisation for the Production of Antioxidant Hydrolysates from Stone Fish Protein Using Bromelain.
This study was targeted to optimise the conditions for the hydrolysis of stone fish protein to produce antioxidant hydrolysates using central composite design (CCD) by response surface methodology (RSM). The stone fish protein was hydrolysed under the optimum predicted conditions defined by pH (6.5), temperature (54°C), E/S ratio (1.5%), and hydrolysis time (360 min). The hydrolysates were then evaluated for 2,2-diphenyl-1-picrylhydrazyl radical (DPPH•) scavenging activity and ferrous ion- (Fe2+-) chelating activity. Results validation showed no significant difference between the experimental values of DPPH...
Source: Evidence-based Complementary and Alternative Medicine - December 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Modernization Trends of Infertility Treatment of Traditional Korean Medicine.
Authors: Park JK, Kim DI Abstract Despite the development of assisted reproductive technology (ART), it is difficult to increase the implantation rate. In Korea, Traditional Korean Medicine, including herbal medicine, is an important component of infertility treatment. Korean medical doctors who are treating infertility often use herbal medicine to promote implantation. In this article, as one of the research works on modernization of Traditional Korean Medicine, we investigated the experimental studies to clarify the effects of herbal medicines that are traditionally used to promote pregnancy. We searched for expe...
Source: Evidence-based Complementary and Alternative Medicine - December 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Qingchang Wenzhong Decoction Attenuates DSS-Induced Colitis in Rats by Reducing Inflammation and Improving Intestinal Barrier Function via Upregulating the MSP/RON Signalling Pathway.
In conclusion, the MSP/RON signalling pathway plays an important role in the pathogenesis of UC by involving the inflammatory response and improving intestinal barrier function. QCWZD appears to attenuate DSS-induced UC in rats by upregulating the MSP/RON signalling pathway. PMID: 29234405 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - December 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Amelioration of Scopolamine-Induced Learning and Memory Impairment by α-Pinene in C57BL/6 Mice.
In this study, we have investigated the neuroprotective effect of α-pinene (APN) against learning and memory impairment induced by scopolamine (SCO, 1 mg/kg, i.p.), a muscarinic receptor antagonist in C57BL/6 mice. Administration of APN (10 mg/kg, i.p.) significantly improved SCO-induced cognitive dysfunction as assessed by Y-maze and passive avoidance tests. In Morris water-maze test, APN effectively shortened the mean escape latency to find the hidden platform during training days. To further elucidate the molecular mechanisms underlying the neuroprotective effect of APN, the expression of proteins in...
Source: Evidence-based Complementary and Alternative Medicine - December 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Jinhong Tablet Reduces Damage of Intestinal Mucosal Barrier in Rats with Acute Biliary Infection via Bcl-2/Bax mRNA and Protein Regulation.
Conclusion: Jinhong Tablet had a positive intervention on acute biliary infection through improving inflammation and intestinal mucosal barrier, inhibiting excessive apoptosis of intestinal epithelial cells via bax and bcl-2 gene, and protein regulation. PMID: 29234407 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - December 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Does the Fragrance of Essential Oils Alleviate the Fatigue Induced by Exercise? A Biochemical Indicator Test in Rats.
Conclusion: The results suggested that the inhalation of an essential oil mixture could powerfully relieve exercise-induced fatigue. PMID: 29234408 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - December 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Antcin-H Isolated from Antrodia cinnamomea Inhibits Renal Cancer Cell Invasion Partly through Inactivation of FAK-ERK-C/EBP- β/c-Fos-MMP-7 Pathways.
This study showed that antcin-H inhibited the growth of human renal carcinoma 786-0 cells; the IC50 value (for 48 h) was 170 μM. Besides, the migration and invasion of 786-0 cells were suppressed by antcin-H under noncytotoxic concentrations (
Source: Evidence-based Complementary and Alternative Medicine - December 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Scorpion Venom Active Polypeptide May Be a New External Drug of Diabetic Ulcer.
Conclusions: Scorpion venom active polypeptide shortens wound healing with a stronger anti-inflammation and antibacterial effect and may be a new and effective topical drug for the treatment of diabetic ulcers. PMID: 29234410 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - December 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Kinematics Analysis of Cervical Rotation-Traction Manipulation Measured by a Motion Capture System.
Authors: Liguo Z, Minshan F, Xunlu Y, Shangquan W, Jie Y Abstract Objectives: To analyze the kinematics of cervical rotation-traction manipulation (CRTM). Methods: An experimental study measuring the kinematics of CRTM was conducted. A total of 18 healthy volunteers participated in the study. A single manipulator operated the CRTM for all subjects. Motion capture technology was adopted to track the trajectory during the CRTM operation. Results: The manipulated side did not influence the cervical spine motion. The motion ranges obtained during CRTM were well below the active range of motion reported in the l...
Source: Evidence-based Complementary and Alternative Medicine - December 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research