Ovarian Cancer Risk Scores Based on Immune-Related Pseudogenes to Predict Overall Survival and Guide Immunotherapy and Chemotherapy
CONCLUSION: It was the first study to identify a novel signature developed by DEirPseus pairs and verify the role in predicting OS, immune infiltrates, immunotherapy, and chemosensitivity. The irPseus are vital factors predicting the prognosis of OC and could act as a novel potential treatment target.PMID:34659427 | PMC:PMC8519701 | DOI:10.1155/2021/1586312 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - October 18, 2021 Category: Complementary Medicine Authors: Jie Zhao Rixiang Zhao Xiaocen Wei Xiaojing Jiang Fan Su Source Type: research

Traditional Chinese Medicine < em > Yang-Gan-Wan < /em > Alleviated Experimental Hepatic Damage by Inhibiting Oxidation, Inflammation, and Apoptosis in Cell and Mouse Models
Evid Based Complement Alternat Med. 2021 Oct 5;2021:2556352. doi: 10.1155/2021/2556352. eCollection 2021.ABSTRACTA hepatoprotective medicine, Yang-Gan-Wan (YGW), was used to treat hepatic damage in cell and mouse models. We performed a 1,1-diphenyl-2- picrylhydrazyl (DPPH) assay and found that YGW exhibited a significantly high free radical scavenging ability. Furthermore, the results of the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay revealed that YGW treatment could alleviate lipopolysaccharide (LPS)-induced damage in Kupffer cells (liver macrophages). Enzyme-linked immunosorbent assay result...
Source: Evidence-based Complementary and Alternative Medicine - October 18, 2021 Category: Complementary Medicine Authors: Chia-Wen Yeh Wan-Jhen Wu Chen-Wen Lu Sheue-Er Wang Wu-Chang Chuang Ming-Chung Lee Chung-Hsin Wu Source Type: research

Evaluation of Antimalarial Potential of Extracts from < em > Alstonia boonei < /em > and < em > Carica papaya < /em > in < em > Plasmodium berghei < /em > -Infected Mice
Evid Based Complement Alternat Med. 2021 Oct 6;2021:2599191. doi: 10.1155/2021/2599191. eCollection 2021.ABSTRACTExtracts of Alstonia boonei and Carica papaya are used in herbal medicine for the treatment of malaria. This work investigated the phytochemical, antioxidant, and antimalarial effects of hydromethanolic extracts of Alstonia boonei and Carica papaya. A four-day chemosuppressive test was conducted to assess the ability of the extracts to prevent establishment of infection. Three doses of the extracts were administered-100, 200, and 400 mg/kg bw-prior to Plasmodium berghei challenge. Change in body weight, parasite...
Source: Evidence-based Complementary and Alternative Medicine - October 18, 2021 Category: Complementary Medicine Authors: Francis O Atanu Favour M Idih Charles O Nwonuma Helal F Hetta Salman Alamery Gaber El-Saber Batiha Source Type: research

LncRNA-URHC Functions as ceRNA to Regulate DNAJB9 Expression by Competitively Binding to miR-5007-3p in Hepatocellular Carcinoma
CONCLUSION: Together, our study elucidated the role of URHC as a miRNA sponge in HCC and shed new light on lncRNA-directed diagnostics and therapeutics in HCC.PMID:34659430 | PMC:PMC8516585 | DOI:10.1155/2021/3031482 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - October 18, 2021 Category: Complementary Medicine Authors: Kunwei Niu Shibin Qu Xuan Zhang Jimin Dai Jianlin Wang Ye Nie Hong Zhang Kaishan Tao Wenjie Song Source Type: research

Antifungal Activity and Acute and Repeated-Dose Toxicity Study of Geranyl Cinnamate Ester in Mice
In conclusion, according to the Organization for Economic Cooperation and Development (OECD) acute toxicity parameters, the geranyl cinnamate ester can be classified into safety category number 5. The results of this study suggested that the geranyl cinnamate ester may be a source of natural antifungals.PMID:34659431 | PMC:PMC8514914 | DOI:10.1155/2021/3493625 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - October 18, 2021 Category: Complementary Medicine Authors: Micheli Zanetti Mikaela Scatolin Amanda Rebonatto Oltramari Maria Luiza Lima da Costa Lopes Rubieli Carla Frezza Zeferino Gustavo Lopes Colpani Liz Girardi M üller D ébora de Oliveira Marcio Ant ônio Fiori Source Type: research

Effect of Acupoint Embedding on Serum Leptin and Hypothalamus Leptin Receptor Expression in Rats with Simple Obesity
CONCLUSION: Acupoint embedding therapy can reduce the level of leptin in blood, increase the number of leptin receptors in hypothalamus, enhance the biological effect of leptin, alleviate the leptin resistance in obese body, change the shape of fat, and regulate the level of blood lipid, so as to achieve the goal of weight loss.PMID:34659432 | PMC:PMC8514909 | DOI:10.1155/2021/3500409 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - October 18, 2021 Category: Complementary Medicine Authors: Qiming Yang Liwei Xing Qinzuo Dong Hongxi Chen Chunlin Xia Xianwu Yue Yuanfeng Wang Li Li Yingjing Luo Mingxing Lai Dong Zhao Zhiyan Zhang Rong Zhao Source Type: research

Antiviral Effect of Hyunggaeyungyo-Tang on A549 Cells Infected with Human Coronavirus
CONCLUSION: Through the reduction of the amount of coronavirus RNA, our research indicates that HGYGT has antiviral effects. The reduction of IKK and iNOS mRNA levels indicate that HGYGT reduces coronavirus RNA expression and may inhibit the replication of coronavirus by acting on NF-kB/Rel pathways to protect oxidative injury. In addition, decreases in mRNA expression levels of proinflammatory cytokines indicate that the HGYGT may relieve the symptoms of coronavirus infections.PMID:34659433 | PMC:PMC8514924 | DOI:10.1155/2021/4494389 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - October 18, 2021 Category: Complementary Medicine Authors: Seo-Young Won In-Chan Seol Ho-Ryong Yoo Yoon-Sik Kim Source Type: research

The Effects of Qigong for Hypertension: A Meta-Analysis of Randomized Controlled Trials
Evid Based Complement Alternat Med. 2021 Oct 8;2021:5622631. doi: 10.1155/2021/5622631. eCollection 2021.ABSTRACTBACKGROUND: Hypertension has been a global public health problem. Qigong as a complementary and alternative therapy is often used to reduce blood pressure. The aim of this meta-analysis was to investigate the effects of Qigong on blood pressure in hypertensive patients.METHODS: Six electronic resource databases were searched from inception to January 2019, and randomized controlled trials of Qigong on hypertension were retrieved. Meta-analysis was conducted according to the guidelines of the Cochrane Collaborati...
Source: Evidence-based Complementary and Alternative Medicine - October 18, 2021 Category: Complementary Medicine Authors: Xiaosheng Dong Zhenguo Shi Meng Ding Xiangren Yi Source Type: research

Electroacupuncture at Bilateral ST36 Acupoints: Inducing the Hypoglycemic Effect through Enhancing Insulin Signal Proteins in a Streptozotocin-Induced Rat Model during Isoflurane Anesthesia
In this study, twenty-six healthy male Wistar rats, weighing 250-350 g and aged 8-10 weeks were tested. Rats in the experimental electroacupuncture (EA) group (n = 13) received 15 Hz electrical stimulation at bilateral ST 36 acupoints for 30 and 60 minutes. Rats in the control group (n = 13) were handled but not subjected to the stimulation treatment. In both IDDM and normal Wistar rats, we observed a negative change in plasma glucose levels when rats were given the EA treatment, but a positive change in plasma glucose without EA treatment relative to baseline. Within the IDDM group, a negative change in FFA levels was obs...
Source: Evidence-based Complementary and Alternative Medicine - October 18, 2021 Category: Complementary Medicine Authors: Kee-Ming Man Yu-Chen Lee Ying-I Chen Yung Hsiang Chen Shih Liang Chang Chieh-Chen Huang Source Type: research

Based on UPLC-Q-TOF-MS/MS, Systematic Network Pharmacology, and Molecular Docking to Explore the Potential Mechanism of Fructus Aurantii for Major Depression Disorder
Evid Based Complement Alternat Med. 2021 Oct 8;2021:6486287. doi: 10.1155/2021/6486287. eCollection 2021.ABSTRACTBACKGROUND: Major Depression Disorder (MDD) is a common mental disease that has become one of the world's major medical diseases. Currently, the Fructus Aurantii (FA) has been widely used to treat depression. However, the active substance ingredients and potential mechanisms of the shell antidepression have not yet been clarified.METHOD: First, we used ultraperformance liquid chromatography-quadrupole/time-of-flight tandem mass (UPLC-QTOF-MS/MS) technology to identify the chemical composition of the FA. Then, it...
Source: Evidence-based Complementary and Alternative Medicine - October 18, 2021 Category: Complementary Medicine Authors: Yating Xie Ying Liu Peng Zheng Tao Zhang Xianwen Ye Minmin Liu Min Huang Quan Wan Jinlian Zhang Source Type: research

A Two-Year Longitudinal Study of the Effectiveness of the CRT < sup > ® < /sup > Bacteria Test in Evaluating Caries Risk in Three-Year-Old Children
Evid Based Complement Alternat Med. 2021 Oct 5;2021:7488855. doi: 10.1155/2021/7488855. eCollection 2021.ABSTRACTOBJECTIVE: To study the correlation between the level of infection with Streptococcus mutans (SM) and lactobacilli (LB) in saliva with existing status and the development of primary dental caries in 3-year-old children and to evaluate the results of CRT® bacteria as a Caries Risk Test.METHODS: A total of 140 3-year-old children were selected for the study. Oral examination was conducted and the levels of infection with SM and LB in saliva were measured using a CRT® bacteria test. Oral reexamination was c...
Source: Evidence-based Complementary and Alternative Medicine - October 18, 2021 Category: Complementary Medicine Authors: Yun Liu Yusheng Meng Min Wu Qian Zhang Source Type: research

Tibetan Medicines for the Treatment of Diabetic Nephropathy
Evid Based Complement Alternat Med. 2021 Oct 6;2021:7845848. doi: 10.1155/2021/7845848. eCollection 2021.ABSTRACTAs an important part of the traditional Chinese medicine system, Tibetan medicine has its unique treatment methods for diabetes mellitus and its complications. Diabetic nephropathy (DN) is one of the most serious diabetic microvascular diseases. Tibetan medicine believes that the occurrence of DN is closely related to renal function changes, and it can be effectively prevented and treated by improving renal lesions. In this paper, we consult ancient books of Tibetan medicine and summarize the medicines that trea...
Source: Evidence-based Complementary and Alternative Medicine - October 18, 2021 Category: Complementary Medicine Authors: Lili Pu Chunhong Yang Liqiong Yu Shiling Li Yaqin Liu Xinan Liu Xianrong Lai Source Type: research

Ginsenoside Re Improves Inflammation and Fibrosis in Hepatic Tissue by Upregulating PPAR < em > γ < /em > Expression and Inhibiting Oxidative Stress in db/db Mice
Evid Based Complement Alternat Med. 2021 Oct 8;2021:9003603. doi: 10.1155/2021/9003603. eCollection 2021.ABSTRACTGinsenoside Re (Re) is the main component of "Zhenyuan Capsule" (ZYC), which was wildly used in clinic in China for adjunctive treatment of coronary heart disease (CHD) and type II diabetes (T2DM). Nonalcoholic fatty liver disease (NAFLD) is one of the most important complications of T2DM, as well as an important risk factor of CHD. The aim of the present study was to investigate the effects of Re on NAFLD in db/db mice, one of the most recognized gene deficient animal models on T2DM. Sixteen db/db mic...
Source: Evidence-based Complementary and Alternative Medicine - October 18, 2021 Category: Complementary Medicine Authors: Yichuan Jiang Dayun Sui Min Li Huali Xu Xiaofeng Yu Jinsha Liu Qian Yu Source Type: research

Genome-Wide Regulation of Acupuncture and Moxibustion on Ulcerative Colitis Rats
Evid Based Complement Alternat Med. 2021 Oct 8;2021:9945121. doi: 10.1155/2021/9945121. eCollection 2021.ABSTRACTAcupuncture and moxibustion have definite clinical effects on treating ulcerative colitis (UC), but their mechanism is still unclear. To investigate the molecular mechanisms, we applied herb-partitioned moxibustion or electroacupuncture at the Tianshu (ST25) points on UC rats and used RNA sequencing to identify molecular consequences. Male Sprague Dawley (SD) rats were divided into 6 groups randomly: the normal control (NC) group, the control + herb-partitioned moxibustion (NCHM) group, the control + electroacup...
Source: Evidence-based Complementary and Alternative Medicine - October 18, 2021 Category: Complementary Medicine Authors: Zhaoqin Wang Yan Huang Di Wang Rumeng Wang Kunshan Li Qin Qi Zhe Ma Muen Gu Handan Zheng Yuan Lu Luyi Wu Source Type: research

Efficacy of Qingfei Paidu Decoction on Patients with COVID-19 Pneumonia in Wuhan, China: A Propensity Score Matching Study
Evid Based Complement Alternat Med. 2021 Oct 5;2021:4303380. doi: 10.1155/2021/4303380. eCollection 2021.ABSTRACTBACKGROUND: In view of the global efforts to develop effective treatments for the current worldwide coronavirus 2019 (COVID-19) pandemic, Qingfei Paidu decoction (QPD), a novel traditional Chinese medicine (TCM) prescription, was formulated as an optimized combination of constituents of classic prescriptions used to treat numerous febrile and respiratory-related diseases. This prescription has been used to treat patients with COVID-19 pneumonia in Wuhan, China. Hypothesis/Purpose. We hypothesized that QPD would ...
Source: Evidence-based Complementary and Alternative Medicine - October 15, 2021 Category: Complementary Medicine Authors: Zhen Liu Shan Du Fei Shao Haibin Li Shuang Xu Xuedi Ma Zhouming Xu Hao Cui Changxiao Yu Yang Wu Feng Wang Liyan Li Rui Chen Hui Qiu Ziren Tang Peng Sun Source Type: research

Clinical Study on the Efficacy of Laparoscopic Hepatectomy and Its Influence on the Expression of Serum VEGF, FGF, and Immune Function
Evid Based Complement Alternat Med. 2021 Oct 5;2021:4432022. doi: 10.1155/2021/4432022. eCollection 2021.ABSTRACTLiver cancer is one of the most common malignant tumors. Partial hepatectomy is the most basic and effective treatment for hepatocellular carcinoma because of its high operative effect and perioperative safety. Open surgery is the most traditional hepatectomy. Although it can completely remove tumor lesions and prolong patient survival, it has disadvantages such as large trauma and long postoperative recovery time. Meanwhile, long-term bed rest can increase the risk of complications such as venous thrombosis and...
Source: Evidence-based Complementary and Alternative Medicine - October 15, 2021 Category: Complementary Medicine Authors: Zhengyong Tang Yi Tang Tianqi Liu Rongjun Liu Shaowei Xie Dongyi Xie Jianrong Yang Yuntian Tang Source Type: research

Network Pharmacology-Based Study of the Underlying Mechanisms of Huangqi Sijunzi Decoction for Alzheimer's Disease
CONCLUSION: HQSJZD was found to have the potential to treat AD by targeting multiple AD-related targets. Formononetin and hederagenin in HQSJZD may regulate multiple signalling pathways through AChE, which might play a therapeutic role in AD.PMID:34650613 | PMC:PMC8510793 | DOI:10.1155/2021/6480381 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - October 15, 2021 Category: Complementary Medicine Authors: Wei Zhang Mingti Lv Yating Shi Yonghui Mu Zhaoyang Yao Zhijun Yang Source Type: research

Exploratory Study on Expression of Fatty Tissue in Gestational Diabetes Mouse
Evid Based Complement Alternat Med. 2021 Oct 5;2021:6813147. doi: 10.1155/2021/6813147. eCollection 2021.ABSTRACTOBJECTIVE: To investigate the changes of UCP1 protein in brown fat by establishing a model of gestational diabetes mellitus through intervention of high fat and carbohydrate diet. To explore the changes of UCP1 protein in brown fat in gestational diabetic mice, and analyze the characteristics of abnormal glucose metabolism in gestational diabetic mice and its relationship with changes in adipocyte morphology and insulin resistance.METHODS: Eighty C57BL/6J pregnant mice were randomly divided into a normal control...
Source: Evidence-based Complementary and Alternative Medicine - October 15, 2021 Category: Complementary Medicine Authors: Xiaoling Zhou Xin Li Tingting Wei Ying Xu Yunyuan Mao Chen Lei Source Type: research

Evaluation of the Antidiarrheal and Antioxidant Effects of Some Chewing Sticks Commonly Used for Oral Hygiene in Ghana
Evid Based Complement Alternat Med. 2021 Oct 5;2021:7270250. doi: 10.1155/2021/7270250. eCollection 2021.ABSTRACTMicrobial etiology of diarrhea is a significant cause of death, especially in children in developing countries. The presence of microbes that are resistant to current treatment options for diarrhea suggests the need to find newer antimicrobial agents for treatment. Therefore, this study focused on investigating the antimicrobial effect of some Ghanaian chewing sticks commonly used for oral hygiene, Azadirachta indica, Garcinia afzelii, and Garcinia kola, against selected diarrhea-causing organisms. From the stem...
Source: Evidence-based Complementary and Alternative Medicine - October 15, 2021 Category: Complementary Medicine Authors: Edward Ken Essuman Adjoa Agyemang Boakye Clement Okraku Tettey Gaston Hunkpe Nii Korley Kortei Henrietta Kwansa-Bentum Sayanika Davi Waikhom Enoch Aninagyei Source Type: research

Studies on the Incompatibility between Bulbus fritillariae and Radix aconiti praeparata Based on the P-gp
This study aimed to investigate the incompatibility mechanism between Bulbus fritillariae and Radix aconiti praeparata based on their interaction with P-glycoprotein (P-gp). The interaction between Bulbus fritillariae and Radix aconiti praeparata during in vitro decocting as well as in vivo absorption was investigated by determining the dry extract yield and by rat single-pass intestinal perfusion (SPIP) model. Inhibition of different species of Bulbus fritillariae on P-gp function was examined using the SPIP model. The mRNA and protein expression of P-gp was determined by PCR and western blotting. The active ingredients o...
Source: Evidence-based Complementary and Alternative Medicine - October 15, 2021 Category: Complementary Medicine Authors: Weijun Liu Ling Wei Yoshikatsu Kanai Xin He Source Type: research

Efficacy of Qingfei Paidu Decoction on Patients with COVID-19 Pneumonia in Wuhan, China: A Propensity Score Matching Study
Evid Based Complement Alternat Med. 2021 Oct 5;2021:4303380. doi: 10.1155/2021/4303380. eCollection 2021.ABSTRACTBACKGROUND: In view of the global efforts to develop effective treatments for the current worldwide coronavirus 2019 (COVID-19) pandemic, Qingfei Paidu decoction (QPD), a novel traditional Chinese medicine (TCM) prescription, was formulated as an optimized combination of constituents of classic prescriptions used to treat numerous febrile and respiratory-related diseases. This prescription has been used to treat patients with COVID-19 pneumonia in Wuhan, China. Hypothesis/Purpose. We hypothesized that QPD would ...
Source: Evidence-based Complementary and Alternative Medicine - October 15, 2021 Category: Complementary Medicine Authors: Zhen Liu Shan Du Fei Shao Haibin Li Shuang Xu Xuedi Ma Zhouming Xu Hao Cui Changxiao Yu Yang Wu Feng Wang Liyan Li Rui Chen Hui Qiu Ziren Tang Peng Sun Source Type: research

Clinical Study on the Efficacy of Laparoscopic Hepatectomy and Its Influence on the Expression of Serum VEGF, FGF, and Immune Function
Evid Based Complement Alternat Med. 2021 Oct 5;2021:4432022. doi: 10.1155/2021/4432022. eCollection 2021.ABSTRACTLiver cancer is one of the most common malignant tumors. Partial hepatectomy is the most basic and effective treatment for hepatocellular carcinoma because of its high operative effect and perioperative safety. Open surgery is the most traditional hepatectomy. Although it can completely remove tumor lesions and prolong patient survival, it has disadvantages such as large trauma and long postoperative recovery time. Meanwhile, long-term bed rest can increase the risk of complications such as venous thrombosis and...
Source: Evidence-based Complementary and Alternative Medicine - October 15, 2021 Category: Complementary Medicine Authors: Zhengyong Tang Yi Tang Tianqi Liu Rongjun Liu Shaowei Xie Dongyi Xie Jianrong Yang Yuntian Tang Source Type: research

Network Pharmacology-Based Study of the Underlying Mechanisms of Huangqi Sijunzi Decoction for Alzheimer's Disease
CONCLUSION: HQSJZD was found to have the potential to treat AD by targeting multiple AD-related targets. Formononetin and hederagenin in HQSJZD may regulate multiple signalling pathways through AChE, which might play a therapeutic role in AD.PMID:34650613 | PMC:PMC8510793 | DOI:10.1155/2021/6480381 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - October 15, 2021 Category: Complementary Medicine Authors: Wei Zhang Mingti Lv Yating Shi Yonghui Mu Zhaoyang Yao Zhijun Yang Source Type: research

Exploratory Study on Expression of Fatty Tissue in Gestational Diabetes Mouse
Evid Based Complement Alternat Med. 2021 Oct 5;2021:6813147. doi: 10.1155/2021/6813147. eCollection 2021.ABSTRACTOBJECTIVE: To investigate the changes of UCP1 protein in brown fat by establishing a model of gestational diabetes mellitus through intervention of high fat and carbohydrate diet. To explore the changes of UCP1 protein in brown fat in gestational diabetic mice, and analyze the characteristics of abnormal glucose metabolism in gestational diabetic mice and its relationship with changes in adipocyte morphology and insulin resistance.METHODS: Eighty C57BL/6J pregnant mice were randomly divided into a normal control...
Source: Evidence-based Complementary and Alternative Medicine - October 15, 2021 Category: Complementary Medicine Authors: Xiaoling Zhou Xin Li Tingting Wei Ying Xu Yunyuan Mao Chen Lei Source Type: research

Evaluation of the Antidiarrheal and Antioxidant Effects of Some Chewing Sticks Commonly Used for Oral Hygiene in Ghana
Evid Based Complement Alternat Med. 2021 Oct 5;2021:7270250. doi: 10.1155/2021/7270250. eCollection 2021.ABSTRACTMicrobial etiology of diarrhea is a significant cause of death, especially in children in developing countries. The presence of microbes that are resistant to current treatment options for diarrhea suggests the need to find newer antimicrobial agents for treatment. Therefore, this study focused on investigating the antimicrobial effect of some Ghanaian chewing sticks commonly used for oral hygiene, Azadirachta indica, Garcinia afzelii, and Garcinia kola, against selected diarrhea-causing organisms. From the stem...
Source: Evidence-based Complementary and Alternative Medicine - October 15, 2021 Category: Complementary Medicine Authors: Edward Ken Essuman Adjoa Agyemang Boakye Clement Okraku Tettey Gaston Hunkpe Nii Korley Kortei Henrietta Kwansa-Bentum Sayanika Davi Waikhom Enoch Aninagyei Source Type: research

Studies on the Incompatibility between Bulbus fritillariae and Radix aconiti praeparata Based on the P-gp
This study aimed to investigate the incompatibility mechanism between Bulbus fritillariae and Radix aconiti praeparata based on their interaction with P-glycoprotein (P-gp). The interaction between Bulbus fritillariae and Radix aconiti praeparata during in vitro decocting as well as in vivo absorption was investigated by determining the dry extract yield and by rat single-pass intestinal perfusion (SPIP) model. Inhibition of different species of Bulbus fritillariae on P-gp function was examined using the SPIP model. The mRNA and protein expression of P-gp was determined by PCR and western blotting. The active ingredients o...
Source: Evidence-based Complementary and Alternative Medicine - October 15, 2021 Category: Complementary Medicine Authors: Weijun Liu Ling Wei Yoshikatsu Kanai Xin He Source Type: research

Efficacy of Qingfei Paidu Decoction on Patients with COVID-19 Pneumonia in Wuhan, China: A Propensity Score Matching Study
Evid Based Complement Alternat Med. 2021 Oct 5;2021:4303380. doi: 10.1155/2021/4303380. eCollection 2021.ABSTRACTBACKGROUND: In view of the global efforts to develop effective treatments for the current worldwide coronavirus 2019 (COVID-19) pandemic, Qingfei Paidu decoction (QPD), a novel traditional Chinese medicine (TCM) prescription, was formulated as an optimized combination of constituents of classic prescriptions used to treat numerous febrile and respiratory-related diseases. This prescription has been used to treat patients with COVID-19 pneumonia in Wuhan, China. Hypothesis/Purpose. We hypothesized that QPD would ...
Source: Evidence-based Complementary and Alternative Medicine - October 15, 2021 Category: Complementary Medicine Authors: Zhen Liu Shan Du Fei Shao Haibin Li Shuang Xu Xuedi Ma Zhouming Xu Hao Cui Changxiao Yu Yang Wu Feng Wang Liyan Li Rui Chen Hui Qiu Ziren Tang Peng Sun Source Type: research

Clinical Study on the Efficacy of Laparoscopic Hepatectomy and Its Influence on the Expression of Serum VEGF, FGF, and Immune Function
Evid Based Complement Alternat Med. 2021 Oct 5;2021:4432022. doi: 10.1155/2021/4432022. eCollection 2021.ABSTRACTLiver cancer is one of the most common malignant tumors. Partial hepatectomy is the most basic and effective treatment for hepatocellular carcinoma because of its high operative effect and perioperative safety. Open surgery is the most traditional hepatectomy. Although it can completely remove tumor lesions and prolong patient survival, it has disadvantages such as large trauma and long postoperative recovery time. Meanwhile, long-term bed rest can increase the risk of complications such as venous thrombosis and...
Source: Evidence-based Complementary and Alternative Medicine - October 15, 2021 Category: Complementary Medicine Authors: Zhengyong Tang Yi Tang Tianqi Liu Rongjun Liu Shaowei Xie Dongyi Xie Jianrong Yang Yuntian Tang Source Type: research

Network Pharmacology-Based Study of the Underlying Mechanisms of Huangqi Sijunzi Decoction for Alzheimer's Disease
CONCLUSION: HQSJZD was found to have the potential to treat AD by targeting multiple AD-related targets. Formononetin and hederagenin in HQSJZD may regulate multiple signalling pathways through AChE, which might play a therapeutic role in AD.PMID:34650613 | PMC:PMC8510793 | DOI:10.1155/2021/6480381 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - October 15, 2021 Category: Complementary Medicine Authors: Wei Zhang Mingti Lv Yating Shi Yonghui Mu Zhaoyang Yao Zhijun Yang Source Type: research

Exploratory Study on Expression of Fatty Tissue in Gestational Diabetes Mouse
Evid Based Complement Alternat Med. 2021 Oct 5;2021:6813147. doi: 10.1155/2021/6813147. eCollection 2021.ABSTRACTOBJECTIVE: To investigate the changes of UCP1 protein in brown fat by establishing a model of gestational diabetes mellitus through intervention of high fat and carbohydrate diet. To explore the changes of UCP1 protein in brown fat in gestational diabetic mice, and analyze the characteristics of abnormal glucose metabolism in gestational diabetic mice and its relationship with changes in adipocyte morphology and insulin resistance.METHODS: Eighty C57BL/6J pregnant mice were randomly divided into a normal control...
Source: Evidence-based Complementary and Alternative Medicine - October 15, 2021 Category: Complementary Medicine Authors: Xiaoling Zhou Xin Li Tingting Wei Ying Xu Yunyuan Mao Chen Lei Source Type: research

Evaluation of the Antidiarrheal and Antioxidant Effects of Some Chewing Sticks Commonly Used for Oral Hygiene in Ghana
Evid Based Complement Alternat Med. 2021 Oct 5;2021:7270250. doi: 10.1155/2021/7270250. eCollection 2021.ABSTRACTMicrobial etiology of diarrhea is a significant cause of death, especially in children in developing countries. The presence of microbes that are resistant to current treatment options for diarrhea suggests the need to find newer antimicrobial agents for treatment. Therefore, this study focused on investigating the antimicrobial effect of some Ghanaian chewing sticks commonly used for oral hygiene, Azadirachta indica, Garcinia afzelii, and Garcinia kola, against selected diarrhea-causing organisms. From the stem...
Source: Evidence-based Complementary and Alternative Medicine - October 15, 2021 Category: Complementary Medicine Authors: Edward Ken Essuman Adjoa Agyemang Boakye Clement Okraku Tettey Gaston Hunkpe Nii Korley Kortei Henrietta Kwansa-Bentum Sayanika Davi Waikhom Enoch Aninagyei Source Type: research

Studies on the Incompatibility between Bulbus fritillariae and Radix aconiti praeparata Based on the P-gp
This study aimed to investigate the incompatibility mechanism between Bulbus fritillariae and Radix aconiti praeparata based on their interaction with P-glycoprotein (P-gp). The interaction between Bulbus fritillariae and Radix aconiti praeparata during in vitro decocting as well as in vivo absorption was investigated by determining the dry extract yield and by rat single-pass intestinal perfusion (SPIP) model. Inhibition of different species of Bulbus fritillariae on P-gp function was examined using the SPIP model. The mRNA and protein expression of P-gp was determined by PCR and western blotting. The active ingredients o...
Source: Evidence-based Complementary and Alternative Medicine - October 15, 2021 Category: Complementary Medicine Authors: Weijun Liu Ling Wei Yoshikatsu Kanai Xin He Source Type: research

Related Psychosocial Factors and Delivery Mode of Depression and Anxiety in Primipara in Late Pregnancy
In this study, 480 cases of normal primiparas who had regular prenatal examination and delivered in hospital were selected as the research object. The Hospital Anxiety and Depression Scale (HAD) was used to record the depressive anxiety state of all study subjects in the third trimester, and we analyzed the effects of age, education background of pregnant women and their spouses, the nature of jobs, family income, prenatal and pregnancy health status, medical insurance status, attend pregnant women's school, and accompanying status of family member on their depressive anxiety state. The influence of depression and anxiety ...
Source: Evidence-based Complementary and Alternative Medicine - October 14, 2021 Category: Complementary Medicine Authors: Xingying Chen Fangfang Hong Dandan Wang Bingyan Bai Yue Xia Chenjie Wang Source Type: research

Chinese Herbal Formula Huoxiang Zhengqi for Dampness Pattern in Atopic Dermatitis and Diarrhea-Predominant Irritable Bowel Syndrome: Rationale and Design of a Master Protocol
This study will provide high-quality efficacy evidence of HXZQ for AD and IBS-D patients and give an example of postmarketing evaluation for CM products under the pattern dominating different disease research model. The study is registered with ChiCTR1900026700 and ChiCTR1900026837.PMID:34646325 | PMC:PMC8505062 | DOI:10.1155/2021/5125568 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - October 14, 2021 Category: Complementary Medicine Authors: Qian Huang Xiaohui Guo Meiling Xuan Wenwei Ouyang Zehuai Wen Source Type: research

Manual Acupuncture at ST37 Modulates TRPV1 in Rats with Acute Visceral Hyperalgesia via Phosphatidylinositol 3-Kinase/Akt Pathway
In this study, the effect and mechanism of MA at Shangjuxu (ST37) and Quchi (LI11) were examined using an acetic acid-induced rat model with visceral hyperalgesia. We demonstrated that MA at ST37 significantly decreased abdominal withdrawal reflex (AWR) scores, proinflammatory cytokine expression (TNF-α, IL-1β, and IL-6), and TRPV1 protein and mRNA expression in rats with acute visceral hyperalgesia compared with the untreated controls, while MA at LI11 showed no effect. The effects of MA at ST37 were reversed after treatment with the PI3K agonist IGF-1 30 min before MA. In rats with visceral hyperalgesia, the u...
Source: Evidence-based Complementary and Alternative Medicine - October 14, 2021 Category: Complementary Medicine Authors: Caiyi Chen Zhi Yu Dong Lin Xuan Wang Xuejun Zhang Feng Ji Lingling He Bin Xu Source Type: research

Influence of Different Antiepileptic Drugs on Blood Ammonia and Homocysteine Levels in Children with Epilepsy
In this study, we performed a study on 106 children with epilepsy who were treated with sodium valproate (the VPA group, n = 37), oxcarbazepine (the OXC group, n = 34), or levetiracetam (the LEV group, n = 35). In addition, the clinical data of epileptic children who were newly diagnosed in the same period without antiepileptic drug (AED) treatment (the untreated group, n = 35) and normal children who received physical examination in our hospital (the healthy group, n = 35) were selected as controls. We analyzed the efficacy and safety of different AEDs, used blood ammonia and homocysteine levels as the observation indicat...
Source: Evidence-based Complementary and Alternative Medicine - October 14, 2021 Category: Complementary Medicine Authors: Meng Sun Ran Zhou Xin Wang Yaying Cheng Source Type: research

Clinical Study on Characteristics and Risk Factors of Coronary Artery Lesions in Young Patients with Acute Myocardial Infarction
In this study, we retrospectively studied the clinical data of 150 AMI patients treated in our hospital from January 2020 to May 2021. The patients were divided into the young group and elderly group according to the difference in age. The number of coronary artery lesions, the degree of coronary artery stenosis, the distribution dominance typing, the position of the lesions, and the presence of collateral circulation were observed and compared between the two groups. Multivariate logistic regression analysis was used to investigate the risk factors affecting coronary artery lesions in young patients with AMI. The results ...
Source: Evidence-based Complementary and Alternative Medicine - October 14, 2021 Category: Complementary Medicine Authors: Hua Liu Jiangang Zhang Zengcai Ma Zesheng Xu Source Type: research

Exploring the Molecular Mechanism of Astragali Radix-Curcumae Rhizoma against Gastric Intraepithelial Neoplasia by Network Pharmacology and Molecular Docking
CONCLUSION: This study revealed the active components and molecular mechanism by which ARCR treatment is effective against GIN through regulating multipathway, such as neuroactive ligand-receptor interaction, nitrogen metabolism, and calcium signaling pathway.PMID:34646329 | PMC:PMC8505068 | DOI:10.1155/2021/8578615 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - October 14, 2021 Category: Complementary Medicine Authors: Yuejin Ji Yajun Liu Jingyi Hu Cheng Cheng Jing Xing Lei Zhu Hong Shen Source Type: research

Qing-Kai-Ling Injection Acts Better Than Shen-Fu Injection in Enhancing the Antitumor Effect of Gefitinib in Resistant Non-Small Cell Lung Cancer Models
Evid Based Complement Alternat Med. 2021 Oct 4;2021:9911935. doi: 10.1155/2021/9911935. eCollection 2021.ABSTRACTPatients with EGFR gene mutation often obtain de novo resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) or develop secondary resistance to EGFR-TKIs after taking EGFR-TKI therapy. Traditional Chinese medicine (TCM) with different treatment principles, in combination with EGFR-TKIs, plays an important role in the treatment of cancers including resistant non-small cell lung cancer (NSCLC). However, inappropriate use of TCM herbs may induce resistance to gefitinib. Therefore, it ...
Source: Evidence-based Complementary and Alternative Medicine - October 14, 2021 Category: Complementary Medicine Authors: Ya-Ya Yu Yan-Juan Zhu Ying Zou Zhen-Zhen Xiao Shuai Shi Yi-Hong Liu Xue-Song Chang Ya-Dong Chen Hai-Bo Zhang Source Type: research

Exploring the Mechanism of Resveratrol in Reducing the Soft Tissue Damage of Osteoarthritis Based on Network Pharmacology and Experimental Pharmacology
Evid Based Complement Alternat Med. 2021 Oct 4;2021:9931957. doi: 10.1155/2021/9931957. eCollection 2021.ABSTRACTAIM: To explore the mechanism of resveratrol in reducing the soft tissue damage of osteoarthritis (OA) based on network pharmacology.METHODS: Pharmmapper was used to predict the target of resveratrol, OMIM and Genecards were used to collect OA-related disease genes, and David ver 6.8 was used for enrichment analysis. Then, animal experiments were carried out for verification. The rat OA model was established and the rats were randomly divided into 4 groups: model group, resveratrol low-dose group, resveratrol hi...
Source: Evidence-based Complementary and Alternative Medicine - October 14, 2021 Category: Complementary Medicine Authors: Zhiyong Long Wang Xiang Jun Li Tiejun Yang Ganpeng Yu Source Type: research

Related Psychosocial Factors and Delivery Mode of Depression and Anxiety in Primipara in Late Pregnancy
In this study, 480 cases of normal primiparas who had regular prenatal examination and delivered in hospital were selected as the research object. The Hospital Anxiety and Depression Scale (HAD) was used to record the depressive anxiety state of all study subjects in the third trimester, and we analyzed the effects of age, education background of pregnant women and their spouses, the nature of jobs, family income, prenatal and pregnancy health status, medical insurance status, attend pregnant women's school, and accompanying status of family member on their depressive anxiety state. The influence of depression and anxiety ...
Source: Evidence-based Complementary and Alternative Medicine - October 14, 2021 Category: Complementary Medicine Authors: Xingying Chen Fangfang Hong Dandan Wang Bingyan Bai Yue Xia Chenjie Wang Source Type: research

Chinese Herbal Formula Huoxiang Zhengqi for Dampness Pattern in Atopic Dermatitis and Diarrhea-Predominant Irritable Bowel Syndrome: Rationale and Design of a Master Protocol
This study will provide high-quality efficacy evidence of HXZQ for AD and IBS-D patients and give an example of postmarketing evaluation for CM products under the pattern dominating different disease research model. The study is registered with ChiCTR1900026700 and ChiCTR1900026837.PMID:34646325 | PMC:PMC8505062 | DOI:10.1155/2021/5125568 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - October 14, 2021 Category: Complementary Medicine Authors: Qian Huang Xiaohui Guo Meiling Xuan Wenwei Ouyang Zehuai Wen Source Type: research

Manual Acupuncture at ST37 Modulates TRPV1 in Rats with Acute Visceral Hyperalgesia via Phosphatidylinositol 3-Kinase/Akt Pathway
In this study, the effect and mechanism of MA at Shangjuxu (ST37) and Quchi (LI11) were examined using an acetic acid-induced rat model with visceral hyperalgesia. We demonstrated that MA at ST37 significantly decreased abdominal withdrawal reflex (AWR) scores, proinflammatory cytokine expression (TNF-α, IL-1β, and IL-6), and TRPV1 protein and mRNA expression in rats with acute visceral hyperalgesia compared with the untreated controls, while MA at LI11 showed no effect. The effects of MA at ST37 were reversed after treatment with the PI3K agonist IGF-1 30 min before MA. In rats with visceral hyperalgesia, the u...
Source: Evidence-based Complementary and Alternative Medicine - October 14, 2021 Category: Complementary Medicine Authors: Caiyi Chen Zhi Yu Dong Lin Xuan Wang Xuejun Zhang Feng Ji Lingling He Bin Xu Source Type: research

Influence of Different Antiepileptic Drugs on Blood Ammonia and Homocysteine Levels in Children with Epilepsy
In this study, we performed a study on 106 children with epilepsy who were treated with sodium valproate (the VPA group, n = 37), oxcarbazepine (the OXC group, n = 34), or levetiracetam (the LEV group, n = 35). In addition, the clinical data of epileptic children who were newly diagnosed in the same period without antiepileptic drug (AED) treatment (the untreated group, n = 35) and normal children who received physical examination in our hospital (the healthy group, n = 35) were selected as controls. We analyzed the efficacy and safety of different AEDs, used blood ammonia and homocysteine levels as the observation indicat...
Source: Evidence-based Complementary and Alternative Medicine - October 14, 2021 Category: Complementary Medicine Authors: Meng Sun Ran Zhou Xin Wang Yaying Cheng Source Type: research

Clinical Study on Characteristics and Risk Factors of Coronary Artery Lesions in Young Patients with Acute Myocardial Infarction
In this study, we retrospectively studied the clinical data of 150 AMI patients treated in our hospital from January 2020 to May 2021. The patients were divided into the young group and elderly group according to the difference in age. The number of coronary artery lesions, the degree of coronary artery stenosis, the distribution dominance typing, the position of the lesions, and the presence of collateral circulation were observed and compared between the two groups. Multivariate logistic regression analysis was used to investigate the risk factors affecting coronary artery lesions in young patients with AMI. The results ...
Source: Evidence-based Complementary and Alternative Medicine - October 14, 2021 Category: Complementary Medicine Authors: Hua Liu Jiangang Zhang Zengcai Ma Zesheng Xu Source Type: research

Exploring the Molecular Mechanism of Astragali Radix-Curcumae Rhizoma against Gastric Intraepithelial Neoplasia by Network Pharmacology and Molecular Docking
CONCLUSION: This study revealed the active components and molecular mechanism by which ARCR treatment is effective against GIN through regulating multipathway, such as neuroactive ligand-receptor interaction, nitrogen metabolism, and calcium signaling pathway.PMID:34646329 | PMC:PMC8505068 | DOI:10.1155/2021/8578615 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - October 14, 2021 Category: Complementary Medicine Authors: Yuejin Ji Yajun Liu Jingyi Hu Cheng Cheng Jing Xing Lei Zhu Hong Shen Source Type: research

Qing-Kai-Ling Injection Acts Better Than Shen-Fu Injection in Enhancing the Antitumor Effect of Gefitinib in Resistant Non-Small Cell Lung Cancer Models
Evid Based Complement Alternat Med. 2021 Oct 4;2021:9911935. doi: 10.1155/2021/9911935. eCollection 2021.ABSTRACTPatients with EGFR gene mutation often obtain de novo resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) or develop secondary resistance to EGFR-TKIs after taking EGFR-TKI therapy. Traditional Chinese medicine (TCM) with different treatment principles, in combination with EGFR-TKIs, plays an important role in the treatment of cancers including resistant non-small cell lung cancer (NSCLC). However, inappropriate use of TCM herbs may induce resistance to gefitinib. Therefore, it ...
Source: Evidence-based Complementary and Alternative Medicine - October 14, 2021 Category: Complementary Medicine Authors: Ya-Ya Yu Yan-Juan Zhu Ying Zou Zhen-Zhen Xiao Shuai Shi Yi-Hong Liu Xue-Song Chang Ya-Dong Chen Hai-Bo Zhang Source Type: research

Exploring the Mechanism of Resveratrol in Reducing the Soft Tissue Damage of Osteoarthritis Based on Network Pharmacology and Experimental Pharmacology
Evid Based Complement Alternat Med. 2021 Oct 4;2021:9931957. doi: 10.1155/2021/9931957. eCollection 2021.ABSTRACTAIM: To explore the mechanism of resveratrol in reducing the soft tissue damage of osteoarthritis (OA) based on network pharmacology.METHODS: Pharmmapper was used to predict the target of resveratrol, OMIM and Genecards were used to collect OA-related disease genes, and David ver 6.8 was used for enrichment analysis. Then, animal experiments were carried out for verification. The rat OA model was established and the rats were randomly divided into 4 groups: model group, resveratrol low-dose group, resveratrol hi...
Source: Evidence-based Complementary and Alternative Medicine - October 14, 2021 Category: Complementary Medicine Authors: Zhiyong Long Wang Xiang Jun Li Tiejun Yang Ganpeng Yu Source Type: research

Effects of Transcutaneous Electrical Acupoint Stimulation on Stress Response during Intubation and Extubation in Patients Undergoing Video-Assisted Thoracoscopic Surgery: A Prospective, Randomized Controlled Trial
Evid Based Complement Alternat Med. 2021 Sep 30;2021:1098915. doi: 10.1155/2021/1098915. eCollection 2021.ABSTRACTOBJECTIVE: The study aimed to evaluate the effect of transcutaneous electrical acupoint stimulation (TEAS) on the stress response during intubation and extubation in patients undergoing video-assisted thoracoscopic surgery (VATS).METHODS: 122 patients undergoing VATS lobectomy were randomly divided into two groups: the TEAS group (n = 62) and the control group (n = 60). Patients in the TEAS group underwent electroacupuncture stimulation of bilateral Neiguan (PC6), Hegu (L14), Lieque (LU7), and Chize (LU5) acupo...
Source: Evidence-based Complementary and Alternative Medicine - October 11, 2021 Category: Complementary Medicine Authors: Zhiyan Yu Yuying Zhang Huan Zhang Xue Zhao Hua Wei Shuangliang He Jianming Liu Tiejun Liu Source Type: research

Application Effect of Case Management Mode Combined with ERAS in Elderly Patients with Hip Fracture
Evid Based Complement Alternat Med. 2021 Sep 30;2021:1175020. doi: 10.1155/2021/1175020. eCollection 2021.ABSTRACTOBJECTIVE: To explore the effect of the case management mode combined with enhanced recovery after surgery (ERAS) in elderly patients with hip fracture.METHODS: A total of 102 elderly hip fracture patients admitted to our hospital from June 2018 to December 2019 were selected. The patients with hip fracture were divided into the control group (n = 51) and the observation group (n = 51) by the random number table method. The control group adopts the conventional nursing mode, and the observation group adopts the...
Source: Evidence-based Complementary and Alternative Medicine - October 11, 2021 Category: Complementary Medicine Authors: Na Peng Jing Li Source Type: research