Research Trends from 2010 to 2020 for Pain Treatment with Acupuncture: A Bibliometric Analysis
CONCLUSION: This study provides a new and in-depth understanding of current acupuncture used for the treatment of pain. We anticipate that this study will stimulate international cooperation among research teams to advance the field.PMID:33859495 | PMC:PMC8043846 | DOI:10.2147/JPR.S300911 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - April 16, 2021 Category: Complementary Medicine Authors: Zhen Gao Jing Zhang Gao-Feng Liu Lai-Xi Ji Source Type: research

< em > Crataegus pinnatifida < /em > Bunge Inhibits RANKL-Induced Osteoclast Differentiation in RAW 264.7 Cells and Prevents Bone Loss in an Ovariectomized Rat Model
In conclusion, CPB prevented osteoclast differentiation in vitro and prevented bone loss in vivo. Therefore, CPB could be a potential alternative medicine for bone diseases, such as osteoporosis.PMID:33859705 | PMC:PMC8024084 | DOI:10.1155/2021/5521562 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - April 16, 2021 Category: Complementary Medicine Authors: Minsun Kim MinBeom Kim Jae-Hyun Kim SooYeon Hong Dong Hee Kim Sangwoo Kim Eun-Young Kim Hyuk-Sang Jung Youngjoo Sohn Source Type: research

Probiotics Can Further Reduce Waist Circumference in Adults with Morbid Obesity after Bariatric Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Evid Based Complement Alternat Med. 2021 Apr 1;2021:5542626. doi: 10.1155/2021/5542626. eCollection 2021.ABSTRACTWhether probiotics could be used as an adjunct to bariatric surgery is controversial. This meta-analysis aimed to evaluate the effects of probiotics on body weight, body mass index (BMI), percentage of the excess weight loss (%EWL), waist circumference (WC), and C-reactive protein (CRP) in adults with obesity after bariatric surgery (BS). PUBMED, EMBASE, and the Cochrane Central Registry of Controlled Trials were searched from the earliest record to March 2020. All randomized controlled trials (RCTs) on the effe...
Source: Evidence-based Complementary and Alternative Medicine - April 16, 2021 Category: Complementary Medicine Authors: Yu Zhang Tong Yan Chenxin Xu Huawu Yang Tongtong Zhang Yanjun Liu Source Type: research

Perioperative Electroacupuncture Can Accelerate the Recovery of Gastrointestinal Function in Cancer Patients Undergoing Pancreatectomy or Gastrectomy: A Randomized Controlled Trial
Evid Based Complement Alternat Med. 2021 Mar 31;2021:5594263. doi: 10.1155/2021/5594263. eCollection 2021.ABSTRACTThe effect of perioperative acupuncture on accelerating gastrointestinal function recovery has been reported in colorectal surgery and distal gastrectomy (Billroth-II). However, the evidence in pancreatectomy and other gastrectomy is still limited. A prospective, randomized controlled trial was conducted between May 2018 and August 2019. Consecutive patients undergoing pancreatectomy or gastrectomy in our hospital were randomly assigned to the electroacupuncture (EA) group and the control group. The patients in...
Source: Evidence-based Complementary and Alternative Medicine - April 16, 2021 Category: Complementary Medicine Authors: Guotong Qiu Tao Huang Yang Lu Lipeng Zhang Yajie Zhao Yong Yuan Hu Ren Jun An Jincao Zhou Rongjun Li Yongxing Du Tuoran Wang Peng Wang Fang He Yunqing Ding Jianwei Zhang Bin Han Zhongmin Lan Shulan Qi Zongze Li Jianyong Gao Zongting Gu Yuemin Sun Xiaofeng Source Type: research

Resting-State fMRI in Studies of Acupuncture
Evid Based Complement Alternat Med. 2021 Mar 23;2021:6616060. doi: 10.1155/2021/6616060. eCollection 2021.ABSTRACTResearch exploring the mechanism of acupuncture has been a hot topic in medicine. Resting-state functional magnetic resonance imaging (rs-fMRI) research is a noninvasive and extensive method, which is aimed at the research of the mechanism of acupuncture. Researchers use fMRI technologies to inspect the acupuncture process. The authors reviewed the application of rs-fMRI in acupuncture research in recent 10 years from the aspects of studying acupoints, subjects, acupuncture methods, and intensities. The results...
Source: Evidence-based Complementary and Alternative Medicine - April 16, 2021 Category: Complementary Medicine Authors: Xiaoling Li Lina Cai Xiaoxu Jiang Xiaohui Liu Jingxian Wang Tiansong Yang Feng Wang Source Type: research

Traditional Chinese Medicine Shenmayizhi Decoction Ameliorates Memory and Cognitive Impairment Induced by Multiple Cerebral Infarctions
This study aimed to illustrate the mechanism by which Shenmayizhi decoction (SMYZD) improves the learning memory of rats with vascular cognitive impairment (VCI). Fifty male and female Wistar rats of specific pathogen-free grade (SPF grade) were used to establish the model by the administration of a microsphere embolization. This was accomplished by injecting sterile, standardized, mass-produced microspheres of uniform particle size (100-200 µm in diameter) in a sodium alginate microsphere vascular embolic agent suspension to induce VCI. The VCI model was successfully established in 40 rats, including both male and f...
Source: Evidence-based Complementary and Alternative Medicine - April 16, 2021 Category: Complementary Medicine Authors: Chengcheng Sun Jiangang Liu Nannan Li Meixia Liu Zenggang Luo Hao Li Source Type: research

Thymoquinone Ameliorates Lung Inflammation and Pathological Changes Observed in Lipopolysaccharide-Induced Lung Injury
Evid Based Complement Alternat Med. 2021 Mar 30;2021:6681729. doi: 10.1155/2021/6681729. eCollection 2021.ABSTRACTAnti-inflammatory, antioxidant, and immunomodulatory effects of thymoquinone (TQ) have been shown. The effects of TQ on lipopolysaccharide- (LPS-) induced inflammation and pathological changes in rats' lung were investigated in this study. Four groups of rats included (1) control (saline treated); (2) LPS (treated with 1 mg/kg/day i.p. for two weeks); and (3 and 4) 5 or 10 mg/kg TQ i.p. 30 min prior to LPS administration. Total and differential WBC counts in the blood and bronchoalveolar fluid (BALF), TGF-&beta...
Source: Evidence-based Complementary and Alternative Medicine - April 16, 2021 Category: Complementary Medicine Authors: Mostafa Boskabady Mohammad Reza Khazdair Rahimeh Bargi Saeideh Saadat Arghavan Memarzia Nema Mohammadian Roshan Mahmoud Hosseini Vahid Reza Askari Mohammad Hossein Boskabady Source Type: research

Gyogamdan, a Traditional Medicine Prescription, Ameliorated Dermal Inflammation and Hyperactive Behavior in an Atopic Dermatitis Mouse Model Exposed to Psychological Stress
This study investigated the effects of an ethanolic extract of Gyogamdan (GGDE) on stress-associated AD models and the underlying mechanisms. 2,4-Dinitrochlorobenzene- (DNCB-) treated BALB/c mice were exposed to social isolation (SI) stress. The effects of orally administered GGDE (100 or 500 mg/kg) were evaluated by ELISA, western blotting, and an open field test (OFT). SI stress exaggerated the skin inflammation and induced locomotor hyperactivity in the AD mouse model. GGDE reduced the levels of IgE, TNF-α, IL-13, eotaxin, and VEGF and mast cell/eosinophil infiltration and prevented the decreases in the levels of ...
Source: Evidence-based Complementary and Alternative Medicine - April 16, 2021 Category: Complementary Medicine Authors: Ly Thi Huong Nguyen Uy Thai Nguyen Min-Jin Choi Tae-Woo Oh In-Jun Yang Heung-Mook Shin Source Type: research

The Feasibility and Positive Effects of Wuqinxi Exercise on the Cognitive and Motor Functions of Patients with Parkinson's Disease: A Pilot Study
CONCLUSION: The results show that the use of Wuqinxi for rehabilitation therapy for cognition is feasible, widely accepted, and effective in patients with Parkinson's disease. This study provides preliminary evidence for further large-scale and controlled studies.PMID:33859712 | PMC:PMC8024081 | DOI:10.1155/2021/8833736 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - April 16, 2021 Category: Complementary Medicine Authors: Mengyue Shen Yan-Ling Pi Zhenlan Li Tao Song Kuncheng Jie Tian Wang Wei Guo Jie Zhuang Zhen Wang Source Type: research

Polysaccharides of Sporoderm-Broken Spore of < em > Ganoderma lucidum < /em > Modulate Adaptive Immune Function via Gut Microbiota Regulation
Evid Based Complement Alternat Med. 2021 Mar 23;2021:8842062. doi: 10.1155/2021/8842062. eCollection 2021.ABSTRACTGanoderma lucidum (Leyss.Fr.) Karst is one of the well-known medicinal macrofungi all over the world, and mounting researches have focused on the polysaccharides derived from the spores of G. lucidum. In the present study, BALB/c mice (n = 8-10) were administered with crude polysaccharides of G. lucidum spores (CPGS) and the refined polysaccharides of G. lucidum spores (RPGS) for 30 days to investigate their effect on the adaptive immune system. Results showed that CPGS and RPGS displayed diverse effects on the...
Source: Evidence-based Complementary and Alternative Medicine - April 16, 2021 Category: Complementary Medicine Authors: Lu Su Dan Li Jiyan Su Enqi Zhang Shaodan Chen Chaoqun Zheng Ting Luo Muxia Li Xiaohong Chen Guoxin Huang Yizhen Xie Shanshan Li Source Type: research

Guidance for Acupuncture Robot with Potentially Utilizing Medical Robotic Technologies
Evid Based Complement Alternat Med. 2021 Mar 31;2021:8883598. doi: 10.1155/2021/8883598. eCollection 2021.ABSTRACTAcupuncture is gaining increasing attention and recognition all over the world. However, a lot of physical labor is paid by acupuncturists. It is natural to resort to a robot which can improve the accuracy as well as the efficacy of therapy. Several teams have separately developed real acupuncture robots or related technologies and even went to the stage of clinical trial and then achieved success commercially. A completed clinical practical acupuncture robot is not far from reach with the combination of existi...
Source: Evidence-based Complementary and Alternative Medicine - April 16, 2021 Category: Complementary Medicine Authors: Tiancheng Xu Youbing Xia Source Type: research

Stimulation of < em > Codonopsis pilosula < /em > Polysaccharide on < em > Bifidobacterium < /em > of Human Gut Bacteria In Vitro
CONCLUSION: CPP has the potential to stimulate the growth of Bifidobacterium of the human gut bacteria and to be benefit to human health.PMID:33859715 | PMC:PMC8024065 | DOI:10.1155/2021/9524913 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - April 16, 2021 Category: Complementary Medicine Authors: Jiankuan Li Lina Dong Yue Liu Jianping Gao Source Type: research

In Vivo Visualization of the Pericardium Meridian with Fluorescent Dyes
Evid Based Complement Alternat Med. 2021 Mar 29;2021:5581227. doi: 10.1155/2021/5581227. eCollection 2021.ABSTRACTThe anatomical basis of acupuncture meridians continues to be enigmatic. Although much attention has been placed on potential correlations with inter/intramuscular fascia or lower electrical impedance, animal studies performed in the past 40 years have shown that tracer dyes-specifically Tc-99m pertechnetate-injected at strategic skin points generate linear migrations closely aligning with acupuncture meridians. To evaluate whether this phenomenon is also observable in humans, we injected two fluorescent dyes-f...
Source: Evidence-based Complementary and Alternative Medicine - April 15, 2021 Category: Complementary Medicine Authors: Tongju Li Bruce Qing Tang Wei-Bo Zhang Minyi Zhao Qingchuan Hu Andrew Ahn Source Type: research

Systematic Evaluation of Clinical Efficacy and Platelet Function of Sofren Injection in the Treatment of Angina Pectoris
Evid Based Complement Alternat Med. 2021 Mar 26;2021:5591137. doi: 10.1155/2021/5591137. eCollection 2021.ABSTRACTTo systematically evaluate the efficacy and safety of sofren injection combined with conventional Western medicine in the treatment of angina pectoris. Randomized controlled trials (RCTs) on the treatment of angina pectoris with sofren injection combined with Western medicine were collected by searching PubMed, the Cochrane Library, Embase, Web of Science, CNKI, Wanfang Database, Weipu Database, and China Biomedical Literature Service System (CBM) by computer with the retrieval time from establishment of databa...
Source: Evidence-based Complementary and Alternative Medicine - April 15, 2021 Category: Complementary Medicine Authors: Genhao Fan Menglin Liu Zuoying Xing Zhaoqi Chen Mingjun Zhu Yongxia Wang Source Type: research

Finger Citron Extract Ameliorates Glycolipid Metabolism and Inflammation by Regulating GLP-1 Secretion via TGR5 Receptors in Obese Rats
Evid Based Complement Alternat Med. 2021 Mar 27;2021:6623379. doi: 10.1155/2021/6623379. eCollection 2021.ABSTRACTFinger citron (FC) is one of many traditional Chinese herbs that have been used to treat obesity. The aim of this study was to elucidate the pharmacological effects and mechanisms of FC on obese rats. Rats were fed with a high-fat diet as a model of obesity and treated with FC at three different dosages for 6 weeks. Pathology in liver tissue was observed. Glucose levels, lipids levels, and inflammatory indicators in serum were evaluated by enzyme-linked immunosorbent assay. Furthermore, the expression of G prot...
Source: Evidence-based Complementary and Alternative Medicine - April 15, 2021 Category: Complementary Medicine Authors: Yujiao Yang Aofei Tian Zhen Wu Yao Wei Xuguang Hu Jiao Guo Source Type: research

Use of Complementary Alternative Medicine and the Associated Factors among Patients with Depression
This study aimed to evaluate the use of CAM and its associated factors in depression. This cross-sectional study was conducted on 300 depressed patients referred to the Yasuj Neurology and Psychiatric Clinic, southern Iran, between 2019 and 2020. A valid semistructured international questionnaire was used; amongst the participants, 230 (77%) were female. The mean age of the patients was 41.47 ± 12.2 years and the mean duration of the disease was 4.49 ± 4.88 years. The prevalence of CAM use was 37.6% among the patients. The results showed a significant difference between the CAM users and nonusers regarding th...
Source: Evidence-based Complementary and Alternative Medicine - April 15, 2021 Category: Complementary Medicine Authors: Hamide Ashraf Alireza Salehi Malihe Sousani Mohammad Hossein Sharifi Source Type: research

Ethnobotanical Study of Medicinal Plants Used to Treat Human and Livestock Ailments in Hulet Eju Enese Woreda, East Gojjam Zone of Amhara Region, Ethiopia
This study revealed that the study area was rich in medicinal plants. Agricultural expansion, charcoal making, and firewood collection were considered major threats to medicinal plants. Therefore, awareness creation to the youth and training to the healers play a pivotal role to prevent the loss of indigenous knowledge.PMID:33854558 | PMC:PMC8021471 | DOI:10.1155/2021/6668541 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - April 15, 2021 Category: Complementary Medicine Authors: Birhanu Adibaru Abebe Samuel Chane Teferi Source Type: research

The Efficacy of < em > Plantago major < /em > Seed on Liver Enzymes in Nonalcoholic Fatty Liver Disease: A Randomized Double-Blind Clinical Trial
CONCLUSION: P. major supplementation with a daily dose of 2 g for 12 weeks improved serum levels of ALT, AST, and TG in patients with NAFLD. Further studies with a larger sample size are recommended.PMID:33854559 | PMC:PMC8019388 | DOI:10.1155/2021/6693887 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - April 15, 2021 Category: Complementary Medicine Authors: Seyedeh Ferdows Jazayeri Roshanak Ghods Fataneh Hashem Dabaghian Asie Shojaii Seyed Ali Al-Hadi Moravej Ebrahim Khadem Seyed Saeed Seyedian Source Type: research

Fuzheng Yiliu Formula Regulates Tumor Invasion and Metastasis through Inhibition of WAVE3 Expression
Evid Based Complement Alternat Med. 2021 Mar 27;2021:8898668. doi: 10.1155/2021/8898668. eCollection 2021.ABSTRACTOBJECTIVE: To explore the mechanism of action of Fuzheng Yiliu formula (FZYLF) in regulation of the invasion and metastasis of MDA-MB-231/Adr human breast cancer cells through WAVE3.METHODS: The MDA-MB-231/Adr cells with high invasive ability were screened by Transwell, and the plasmid with high WAVE3 expression was made for transfection. Plasmid transfection efficiency and protein expression level were verified by polymerase chain reaction (PCR) and western blotting (WB). The effect of FZYLF on cell proliferat...
Source: Evidence-based Complementary and Alternative Medicine - April 15, 2021 Category: Complementary Medicine Authors: Wen-Li Chen Huan-Huan Bai Li-Wei Liu Hong-Yu Chen Qi Shi Li-Sheng Chang Xiao-Jun Gou Jun Qian Source Type: research

Efficacy and Safety of Ningmitai Capsules in Patients with Chronic Epididymitis: A Prospective, Parallel Randomized Controlled Clinical Trial
Evid Based Complement Alternat Med. 2021 Mar 27;2021:9752592. doi: 10.1155/2021/9752592. eCollection 2021.ABSTRACTOBJECTIVES: To evaluate the efficacy and safety of Ningmitai (NMT) capsules in patients with chronic epididymitis.METHODS: This prospective randomized controlled trial included 112 patients diagnosed with chronic epididymitis. The patients were randomized (1 : 1 : 1) to receive levofloxacin (LVX), NMT, or NMT combined with LVX for 4 weeks. The patients were followed up at 2 and 4 weeks after initiation of treatment and were evaluated in terms of Chronic Epididymitis Symptom Index (CESI) scores, epididymal nodul...
Source: Evidence-based Complementary and Alternative Medicine - April 15, 2021 Category: Complementary Medicine Authors: Zhang Jing Guan Liying Wang Zhenqing Zhang Hui Liu Shuai Sun Dingqi Fu Qiang Zhang Keqin Source Type: research

Resveratrol Alleviates Vascular Endothelial Damage Caused by Lower-Extremity Ischemia Reperfusion (I/R) through Regulating Keap1/Nrf2 Signaling-Mediated Oxidative Stress
Evid Based Complement Alternat Med. 2021 Mar 24;2021:5556603. doi: 10.1155/2021/5556603. eCollection 2021.ABSTRACTThe present study aims to investigate the protective effects of Resveratrol (RSV) against vascular endothelial damage caused by lower-extremity I/R and the underlying preliminary mechanism. The in vitro hypoxia reoxygenation (HR) model was established on HUVECs. Lower-extremity I/R model was established on rats followed by being treated with RSV and the pathological state of artery was evaluated by HE and EVG staining, while the apoptotic state of artery was detected by TUNEL assay. The cell viability was detec...
Source: Evidence-based Complementary and Alternative Medicine - April 9, 2021 Category: Complementary Medicine Authors: Xiaojun Song Zhili Liu Rong Zeng Jiang Shao Yuehong Zheng Wei Ye Source Type: research

Curcumin Ameliorates Palmitic Acid-Induced Saos-2 Cell Apoptosis Via Inhibiting Oxidative Stress and Autophagy
CONCLUSION: The present study demonstrated that oxidative stress is an inducer of autophagy and that curcumin can attenuate excess autophagy and cell apoptosis by inhibiting oxidative stress in PA-induced Saos-2 cells.PMID:33833814 | PMC:PMC8018866 | DOI:10.1155/2021/5563660 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - April 9, 2021 Category: Complementary Medicine Authors: Baicheng Ma Gaopeng Guan Qizhuang Lv Lei Yang Source Type: research

Therapeutic of Candesartan and Music Therapy in Diabetic Retinopathy with Depression in Rats
In conclusion, candesartan and music therapy have an additive effect in DM with both visual impairment and depression, which might serve a potential alternative treatment for this complex disease.PMID:33833815 | PMC:PMC8018856 | DOI:10.1155/2021/5570356 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - April 9, 2021 Category: Complementary Medicine Authors: Chengping Luo Huimin Fan Shaojun Li Yuling Zou Source Type: research

Phytochemical Analysis Using UPLC-MS < sup > n < /sup > Combined with Network Pharmacology Approaches to Explore the Biomarkers for the Quality Control of the Anticancer Tannin Fraction of < em > Phyllanthus emblica < /em > L. Habitat in Nepal
This study was to find the active ingredients of the tannin fraction using UPLC-MSn and network pharmacology. First of all, the UPLC-MSn method was employed to obtain high-resolution mass spectra of different components, and 110 compounds were obtained. Then a network pharmacology method was used to find biomarkers for quality control. Network pharmacology results showed that gallic acid, punicalagin A, punicalagin B, methyl gallate, geraniin, corilagin, chebulinic acid, chebulagic acid, and ellagic acid should be the biomarkers of the tannin fraction. Furthermore, 9 components were detected in the serum, which also proved...
Source: Evidence-based Complementary and Alternative Medicine - April 9, 2021 Category: Complementary Medicine Authors: Lingfang Wu Qiunan Zhang Wenyi Liang Yongben Ma Liying Niu Lanzhen Zhang Source Type: research

Clinical and Antimicrobial Evaluation of < em > Copaifera langsdorffii < /em > Desf. Dental Varnish in Children: A Clinical Study
The objective of this study was to evaluate the clinical and microbiological efficacies of (C. langsdorffii) dental varnish in children at high risk of dental caries..METHODS: This is a longitudinal, randomized, controlled clinical trial. Ninety high-risk caries-free children (ICDAS II = 0) were recruited and randomly divided into three groups: C. langsdorffii, chlorhexidine, or fluoride. The varnishes were applied on the second deciduous molars for three times: baseline (D0), after 90 days (D90), and after 180 days (D180). Saliva was collected on D0, D90, D180, and D360 to evaluate S. mutans reduction. Statistics were car...
Source: Evidence-based Complementary and Alternative Medicine - April 9, 2021 Category: Complementary Medicine Authors: L ídia Audrey Rocha Valadas Patr ícia Leal Dantas Lobo Said Gon çalves da Cruz Fonseca Francisco Vagnaldo Fechine Edilson Martins Rodrigues Neto Marta Maria de Fran ça Fonteles Lorena Ribeiro de Aguiar Tr évia Hilda Lara Prado Vasconcelos Sandra Mara Source Type: research

An Apriori Algorithm-Based Association Rule Analysis to Identify Acupoint Combinations for Treating Diabetic Gastroparesis
Evid Based Complement Alternat Med. 2021 Mar 25;2021:6649331. doi: 10.1155/2021/6649331. eCollection 2021.ABSTRACTWe explored the potential association rules within acupoints in treating diabetic gastroparesis (DGP) using Apriori algorithm complemented with another partition-based algorithm, a frequent pattern growth algorithm. Apriori algorithm is a data mining-based analysis that is widely applied in various fields, such as business and medicine, to mine frequent patterns in datasets. To search for effective acupoint combinations in the treatment of DGP, we implemented Apriori algorithm to investigate the association rul...
Source: Evidence-based Complementary and Alternative Medicine - April 9, 2021 Category: Complementary Medicine Authors: Ping-Hsun Lu Jui-Lin Keng Fu-Ming Tsai Po-Hsuan Lu Chan-Yen Kuo Source Type: research

The Exploration of Novel Pharmacophore Characteristics and Multidirectional Elucidation of Structure-Activity Relationship and Mechanism of Sesquiterpene Pyridine Alkaloids from Tripterygium Based on Computational Approaches
In this study, 55 sesquiterpene pyridine alkaloids from Tripterygium were subjected to identification of pharmacophore characteristics and potential targets analysis. Our results revealed that the greatest structural difference of these compounds was in the pyridine ring and the pharmacophore model-5 (Pm-05) was the best model that consisted of three features including hydrogen bond acceptor (HBA), hydrogen bond donor (HBD), and hydrophobic (HY), especially hydrophobic group located in the pyridine ring. It was proposed that 2-(carboxyalkyl) nicotinic acid part possessing a pyridine ring system was not only a pharmacologic...
Source: Evidence-based Complementary and Alternative Medicine - April 9, 2021 Category: Complementary Medicine Authors: Chengyan Long Yang Yang Yong Yang Sixing Huang Xiaomei Zhang Wei Du Dajian Yang Yanlei Guo Li Zhang Source Type: research

Teratogenic Effect of High Dose of < em > Syzygium guineense < /em > (Myrtaceae) Leaves on Wistar Albino Rat Embryos and Fetuses
This study was planned to investigate the teratogenic potential of S. guineense leaves on rat embryos and fetuses. Five groups of Wistar albino rats, each consisting of ten pregnant rats, were used as experimental animals. Groups I-III rats were treated with 250, 500, and 1000 mg/kg of hydroethanolic extract of S. guineense leaves, and groups IV and V were control and ad libitum control, respectively. Rats were treated during day 6-12 of gestation. Embryos and fetuses were retrieved at day 12 and day 20 of gestation, respectively. The embryos were assessed for developmental delays and growth retardation. The fetuses were e...
Source: Evidence-based Complementary and Alternative Medicine - April 9, 2021 Category: Complementary Medicine Authors: Melese Abebe Kaleab Asres Yonas Bekuretsion Samuel Woldkidan Eyob Debebe Girma Seyoum Source Type: research

ARHGEF10L Promotes Cervical Tumorigenesis via RhoA-Mediated Signaling
This study investigated the pathogenic role and mechanism of ARHGEF10L in cervical tumors.METHODS: The HeLa cell line, which was derived from cervical carcinoma, was transfected with ARHGEF10L-overexpressing plasmids or anti-ARHGEF10L siRNA. Cell counting kit-8 assays, wound-healing assays, and cell apoptosis assays were performed to investigate the effects of ARHGEF10L on cell activities. A Rho pull-down assay and RNA-sequencing analysis were performed to investigate the pathogenic pathway of ARHGEF10L involvement in cervical tumors.RESULTS: ARHGEF10L overexpression promoted cell proliferation and migration, reduced cell ...
Source: Evidence-based Complementary and Alternative Medicine - April 9, 2021 Category: Complementary Medicine Authors: Junyi Tang Kehua Fang Chang Li Xiaotian Chang Source Type: research

Cupping Therapy for Migraine: A PRISMA-Compliant Systematic Review and Meta-Analysis of Randomized Controlled Trials
CONCLUSION: Cupping therapy could be effective for the treatment of migraine. However, the qualities of the evidence were low, so well-designed RCTs are needed to confirm the effectiveness of cupping. Systematic review registration: PROSPERO registration number is CRD42017054979.PMID:33833822 | PMC:PMC8016589 | DOI:10.1155/2021/7582581 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - April 9, 2021 Category: Complementary Medicine Authors: Jihye Seo Hongmin Chu Cheol-Hyun Kim Kang-Keyng Sung Sangkwan Lee Source Type: research

Resveratrol Alleviates Vascular Endothelial Damage Caused by Lower-Extremity Ischemia Reperfusion (I/R) through Regulating Keap1/Nrf2 Signaling-Mediated Oxidative Stress
Evid Based Complement Alternat Med. 2021 Mar 24;2021:5556603. doi: 10.1155/2021/5556603. eCollection 2021.ABSTRACTThe present study aims to investigate the protective effects of Resveratrol (RSV) against vascular endothelial damage caused by lower-extremity I/R and the underlying preliminary mechanism. The in vitro hypoxia reoxygenation (HR) model was established on HUVECs. Lower-extremity I/R model was established on rats followed by being treated with RSV and the pathological state of artery was evaluated by HE and EVG staining, while the apoptotic state of artery was detected by TUNEL assay. The cell viability was detec...
Source: Evidence-based Complementary and Alternative Medicine - April 9, 2021 Category: Complementary Medicine Authors: Xiaojun Song Zhili Liu Rong Zeng Jiang Shao Yuehong Zheng Wei Ye Source Type: research

Curcumin Ameliorates Palmitic Acid-Induced Saos-2 Cell Apoptosis Via Inhibiting Oxidative Stress and Autophagy
CONCLUSION: The present study demonstrated that oxidative stress is an inducer of autophagy and that curcumin can attenuate excess autophagy and cell apoptosis by inhibiting oxidative stress in PA-induced Saos-2 cells.PMID:33833814 | PMC:PMC8018866 | DOI:10.1155/2021/5563660 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - April 9, 2021 Category: Complementary Medicine Authors: Baicheng Ma Gaopeng Guan Qizhuang Lv Lei Yang Source Type: research

Therapeutic of Candesartan and Music Therapy in Diabetic Retinopathy with Depression in Rats
In conclusion, candesartan and music therapy have an additive effect in DM with both visual impairment and depression, which might serve a potential alternative treatment for this complex disease.PMID:33833815 | PMC:PMC8018856 | DOI:10.1155/2021/5570356 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - April 9, 2021 Category: Complementary Medicine Authors: Chengping Luo Huimin Fan Shaojun Li Yuling Zou Source Type: research

Phytochemical Analysis Using UPLC-MS < sup > n < /sup > Combined with Network Pharmacology Approaches to Explore the Biomarkers for the Quality Control of the Anticancer Tannin Fraction of < em > Phyllanthus emblica < /em > L. Habitat in Nepal
This study was to find the active ingredients of the tannin fraction using UPLC-MSn and network pharmacology. First of all, the UPLC-MSn method was employed to obtain high-resolution mass spectra of different components, and 110 compounds were obtained. Then a network pharmacology method was used to find biomarkers for quality control. Network pharmacology results showed that gallic acid, punicalagin A, punicalagin B, methyl gallate, geraniin, corilagin, chebulinic acid, chebulagic acid, and ellagic acid should be the biomarkers of the tannin fraction. Furthermore, 9 components were detected in the serum, which also proved...
Source: Evidence-based Complementary and Alternative Medicine - April 9, 2021 Category: Complementary Medicine Authors: Lingfang Wu Qiunan Zhang Wenyi Liang Yongben Ma Liying Niu Lanzhen Zhang Source Type: research

Clinical and Antimicrobial Evaluation of < em > Copaifera langsdorffii < /em > Desf. Dental Varnish in Children: A Clinical Study
The objective of this study was to evaluate the clinical and microbiological efficacies of (C. langsdorffii) dental varnish in children at high risk of dental caries..METHODS: This is a longitudinal, randomized, controlled clinical trial. Ninety high-risk caries-free children (ICDAS II = 0) were recruited and randomly divided into three groups: C. langsdorffii, chlorhexidine, or fluoride. The varnishes were applied on the second deciduous molars for three times: baseline (D0), after 90 days (D90), and after 180 days (D180). Saliva was collected on D0, D90, D180, and D360 to evaluate S. mutans reduction. Statistics were car...
Source: Evidence-based Complementary and Alternative Medicine - April 9, 2021 Category: Complementary Medicine Authors: L ídia Audrey Rocha Valadas Patr ícia Leal Dantas Lobo Said Gon çalves da Cruz Fonseca Francisco Vagnaldo Fechine Edilson Martins Rodrigues Neto Marta Maria de Fran ça Fonteles Lorena Ribeiro de Aguiar Tr évia Hilda Lara Prado Vasconcelos Sandra Mara Source Type: research

An Apriori Algorithm-Based Association Rule Analysis to Identify Acupoint Combinations for Treating Diabetic Gastroparesis
Evid Based Complement Alternat Med. 2021 Mar 25;2021:6649331. doi: 10.1155/2021/6649331. eCollection 2021.ABSTRACTWe explored the potential association rules within acupoints in treating diabetic gastroparesis (DGP) using Apriori algorithm complemented with another partition-based algorithm, a frequent pattern growth algorithm. Apriori algorithm is a data mining-based analysis that is widely applied in various fields, such as business and medicine, to mine frequent patterns in datasets. To search for effective acupoint combinations in the treatment of DGP, we implemented Apriori algorithm to investigate the association rul...
Source: Evidence-based Complementary and Alternative Medicine - April 9, 2021 Category: Complementary Medicine Authors: Ping-Hsun Lu Jui-Lin Keng Fu-Ming Tsai Po-Hsuan Lu Chan-Yen Kuo Source Type: research

The Exploration of Novel Pharmacophore Characteristics and Multidirectional Elucidation of Structure-Activity Relationship and Mechanism of Sesquiterpene Pyridine Alkaloids from Tripterygium Based on Computational Approaches
In this study, 55 sesquiterpene pyridine alkaloids from Tripterygium were subjected to identification of pharmacophore characteristics and potential targets analysis. Our results revealed that the greatest structural difference of these compounds was in the pyridine ring and the pharmacophore model-5 (Pm-05) was the best model that consisted of three features including hydrogen bond acceptor (HBA), hydrogen bond donor (HBD), and hydrophobic (HY), especially hydrophobic group located in the pyridine ring. It was proposed that 2-(carboxyalkyl) nicotinic acid part possessing a pyridine ring system was not only a pharmacologic...
Source: Evidence-based Complementary and Alternative Medicine - April 9, 2021 Category: Complementary Medicine Authors: Chengyan Long Yang Yang Yong Yang Sixing Huang Xiaomei Zhang Wei Du Dajian Yang Yanlei Guo Li Zhang Source Type: research

Teratogenic Effect of High Dose of < em > Syzygium guineense < /em > (Myrtaceae) Leaves on Wistar Albino Rat Embryos and Fetuses
This study was planned to investigate the teratogenic potential of S. guineense leaves on rat embryos and fetuses. Five groups of Wistar albino rats, each consisting of ten pregnant rats, were used as experimental animals. Groups I-III rats were treated with 250, 500, and 1000 mg/kg of hydroethanolic extract of S. guineense leaves, and groups IV and V were control and ad libitum control, respectively. Rats were treated during day 6-12 of gestation. Embryos and fetuses were retrieved at day 12 and day 20 of gestation, respectively. The embryos were assessed for developmental delays and growth retardation. The fetuses were e...
Source: Evidence-based Complementary and Alternative Medicine - April 9, 2021 Category: Complementary Medicine Authors: Melese Abebe Kaleab Asres Yonas Bekuretsion Samuel Woldkidan Eyob Debebe Girma Seyoum Source Type: research

ARHGEF10L Promotes Cervical Tumorigenesis via RhoA-Mediated Signaling
This study investigated the pathogenic role and mechanism of ARHGEF10L in cervical tumors.METHODS: The HeLa cell line, which was derived from cervical carcinoma, was transfected with ARHGEF10L-overexpressing plasmids or anti-ARHGEF10L siRNA. Cell counting kit-8 assays, wound-healing assays, and cell apoptosis assays were performed to investigate the effects of ARHGEF10L on cell activities. A Rho pull-down assay and RNA-sequencing analysis were performed to investigate the pathogenic pathway of ARHGEF10L involvement in cervical tumors.RESULTS: ARHGEF10L overexpression promoted cell proliferation and migration, reduced cell ...
Source: Evidence-based Complementary and Alternative Medicine - April 9, 2021 Category: Complementary Medicine Authors: Junyi Tang Kehua Fang Chang Li Xiaotian Chang Source Type: research

Cupping Therapy for Migraine: A PRISMA-Compliant Systematic Review and Meta-Analysis of Randomized Controlled Trials
CONCLUSION: Cupping therapy could be effective for the treatment of migraine. However, the qualities of the evidence were low, so well-designed RCTs are needed to confirm the effectiveness of cupping. Systematic review registration: PROSPERO registration number is CRD42017054979.PMID:33833822 | PMC:PMC8016589 | DOI:10.1155/2021/7582581 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - April 9, 2021 Category: Complementary Medicine Authors: Jihye Seo Hongmin Chu Cheol-Hyun Kim Kang-Keyng Sung Sangkwan Lee Source Type: research

Resveratrol Alleviates Vascular Endothelial Damage Caused by Lower-Extremity Ischemia Reperfusion (I/R) through Regulating Keap1/Nrf2 Signaling-Mediated Oxidative Stress
Evid Based Complement Alternat Med. 2021 Mar 24;2021:5556603. doi: 10.1155/2021/5556603. eCollection 2021.ABSTRACTThe present study aims to investigate the protective effects of Resveratrol (RSV) against vascular endothelial damage caused by lower-extremity I/R and the underlying preliminary mechanism. The in vitro hypoxia reoxygenation (HR) model was established on HUVECs. Lower-extremity I/R model was established on rats followed by being treated with RSV and the pathological state of artery was evaluated by HE and EVG staining, while the apoptotic state of artery was detected by TUNEL assay. The cell viability was detec...
Source: Evidence-based Complementary and Alternative Medicine - April 9, 2021 Category: Complementary Medicine Authors: Xiaojun Song Zhili Liu Rong Zeng Jiang Shao Yuehong Zheng Wei Ye Source Type: research

Curcumin Ameliorates Palmitic Acid-Induced Saos-2 Cell Apoptosis Via Inhibiting Oxidative Stress and Autophagy
CONCLUSION: The present study demonstrated that oxidative stress is an inducer of autophagy and that curcumin can attenuate excess autophagy and cell apoptosis by inhibiting oxidative stress in PA-induced Saos-2 cells.PMID:33833814 | PMC:PMC8018866 | DOI:10.1155/2021/5563660 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - April 9, 2021 Category: Complementary Medicine Authors: Baicheng Ma Gaopeng Guan Qizhuang Lv Lei Yang Source Type: research

Therapeutic of Candesartan and Music Therapy in Diabetic Retinopathy with Depression in Rats
In conclusion, candesartan and music therapy have an additive effect in DM with both visual impairment and depression, which might serve a potential alternative treatment for this complex disease.PMID:33833815 | PMC:PMC8018856 | DOI:10.1155/2021/5570356 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - April 9, 2021 Category: Complementary Medicine Authors: Chengping Luo Huimin Fan Shaojun Li Yuling Zou Source Type: research

Phytochemical Analysis Using UPLC-MS < sup > n < /sup > Combined with Network Pharmacology Approaches to Explore the Biomarkers for the Quality Control of the Anticancer Tannin Fraction of < em > Phyllanthus emblica < /em > L. Habitat in Nepal
This study was to find the active ingredients of the tannin fraction using UPLC-MSn and network pharmacology. First of all, the UPLC-MSn method was employed to obtain high-resolution mass spectra of different components, and 110 compounds were obtained. Then a network pharmacology method was used to find biomarkers for quality control. Network pharmacology results showed that gallic acid, punicalagin A, punicalagin B, methyl gallate, geraniin, corilagin, chebulinic acid, chebulagic acid, and ellagic acid should be the biomarkers of the tannin fraction. Furthermore, 9 components were detected in the serum, which also proved...
Source: Evidence-based Complementary and Alternative Medicine - April 9, 2021 Category: Complementary Medicine Authors: Lingfang Wu Qiunan Zhang Wenyi Liang Yongben Ma Liying Niu Lanzhen Zhang Source Type: research

Clinical and Antimicrobial Evaluation of < em > Copaifera langsdorffii < /em > Desf. Dental Varnish in Children: A Clinical Study
The objective of this study was to evaluate the clinical and microbiological efficacies of (C. langsdorffii) dental varnish in children at high risk of dental caries..METHODS: This is a longitudinal, randomized, controlled clinical trial. Ninety high-risk caries-free children (ICDAS II = 0) were recruited and randomly divided into three groups: C. langsdorffii, chlorhexidine, or fluoride. The varnishes were applied on the second deciduous molars for three times: baseline (D0), after 90 days (D90), and after 180 days (D180). Saliva was collected on D0, D90, D180, and D360 to evaluate S. mutans reduction. Statistics were car...
Source: Evidence-based Complementary and Alternative Medicine - April 9, 2021 Category: Complementary Medicine Authors: L ídia Audrey Rocha Valadas Patr ícia Leal Dantas Lobo Said Gon çalves da Cruz Fonseca Francisco Vagnaldo Fechine Edilson Martins Rodrigues Neto Marta Maria de Fran ça Fonteles Lorena Ribeiro de Aguiar Tr évia Hilda Lara Prado Vasconcelos Sandra Mara Source Type: research

An Apriori Algorithm-Based Association Rule Analysis to Identify Acupoint Combinations for Treating Diabetic Gastroparesis
Evid Based Complement Alternat Med. 2021 Mar 25;2021:6649331. doi: 10.1155/2021/6649331. eCollection 2021.ABSTRACTWe explored the potential association rules within acupoints in treating diabetic gastroparesis (DGP) using Apriori algorithm complemented with another partition-based algorithm, a frequent pattern growth algorithm. Apriori algorithm is a data mining-based analysis that is widely applied in various fields, such as business and medicine, to mine frequent patterns in datasets. To search for effective acupoint combinations in the treatment of DGP, we implemented Apriori algorithm to investigate the association rul...
Source: Evidence-based Complementary and Alternative Medicine - April 9, 2021 Category: Complementary Medicine Authors: Ping-Hsun Lu Jui-Lin Keng Fu-Ming Tsai Po-Hsuan Lu Chan-Yen Kuo Source Type: research

The Exploration of Novel Pharmacophore Characteristics and Multidirectional Elucidation of Structure-Activity Relationship and Mechanism of Sesquiterpene Pyridine Alkaloids from Tripterygium Based on Computational Approaches
In this study, 55 sesquiterpene pyridine alkaloids from Tripterygium were subjected to identification of pharmacophore characteristics and potential targets analysis. Our results revealed that the greatest structural difference of these compounds was in the pyridine ring and the pharmacophore model-5 (Pm-05) was the best model that consisted of three features including hydrogen bond acceptor (HBA), hydrogen bond donor (HBD), and hydrophobic (HY), especially hydrophobic group located in the pyridine ring. It was proposed that 2-(carboxyalkyl) nicotinic acid part possessing a pyridine ring system was not only a pharmacologic...
Source: Evidence-based Complementary and Alternative Medicine - April 9, 2021 Category: Complementary Medicine Authors: Chengyan Long Yang Yang Yong Yang Sixing Huang Xiaomei Zhang Wei Du Dajian Yang Yanlei Guo Li Zhang Source Type: research

Teratogenic Effect of High Dose of < em > Syzygium guineense < /em > (Myrtaceae) Leaves on Wistar Albino Rat Embryos and Fetuses
This study was planned to investigate the teratogenic potential of S. guineense leaves on rat embryos and fetuses. Five groups of Wistar albino rats, each consisting of ten pregnant rats, were used as experimental animals. Groups I-III rats were treated with 250, 500, and 1000 mg/kg of hydroethanolic extract of S. guineense leaves, and groups IV and V were control and ad libitum control, respectively. Rats were treated during day 6-12 of gestation. Embryos and fetuses were retrieved at day 12 and day 20 of gestation, respectively. The embryos were assessed for developmental delays and growth retardation. The fetuses were e...
Source: Evidence-based Complementary and Alternative Medicine - April 9, 2021 Category: Complementary Medicine Authors: Melese Abebe Kaleab Asres Yonas Bekuretsion Samuel Woldkidan Eyob Debebe Girma Seyoum Source Type: research

ARHGEF10L Promotes Cervical Tumorigenesis via RhoA-Mediated Signaling
This study investigated the pathogenic role and mechanism of ARHGEF10L in cervical tumors.METHODS: The HeLa cell line, which was derived from cervical carcinoma, was transfected with ARHGEF10L-overexpressing plasmids or anti-ARHGEF10L siRNA. Cell counting kit-8 assays, wound-healing assays, and cell apoptosis assays were performed to investigate the effects of ARHGEF10L on cell activities. A Rho pull-down assay and RNA-sequencing analysis were performed to investigate the pathogenic pathway of ARHGEF10L involvement in cervical tumors.RESULTS: ARHGEF10L overexpression promoted cell proliferation and migration, reduced cell ...
Source: Evidence-based Complementary and Alternative Medicine - April 9, 2021 Category: Complementary Medicine Authors: Junyi Tang Kehua Fang Chang Li Xiaotian Chang Source Type: research

Cupping Therapy for Migraine: A PRISMA-Compliant Systematic Review and Meta-Analysis of Randomized Controlled Trials
CONCLUSION: Cupping therapy could be effective for the treatment of migraine. However, the qualities of the evidence were low, so well-designed RCTs are needed to confirm the effectiveness of cupping. Systematic review registration: PROSPERO registration number is CRD42017054979.PMID:33833822 | PMC:PMC8016589 | DOI:10.1155/2021/7582581 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - April 9, 2021 Category: Complementary Medicine Authors: Jihye Seo Hongmin Chu Cheol-Hyun Kim Kang-Keyng Sung Sangkwan Lee Source Type: research