Optimization of Bioactive Ingredient Extraction from Chinese Herbal Medicine Glycyrrhiza glabra: A Comparative Study of Three Optimization Models.
Authors: Yu L, Jin W, Li X, Zhang Y Abstract The ultraviolet spectrophotometric method is often used for determining the content of glycyrrhizic acid from Chinese herbal medicine Glycyrrhiza glabra. Based on the traditional single variable approach, four extraction parameters of ammonia concentration, ethanol concentration, circumfluence time, and liquid-solid ratio are adopted as the independent extraction variables. In the present work, central composite design of four factors and five levels is applied to design the extraction experiments. Subsequently, the prediction models of response surface methodology, arti...
Source: Evidence-based Complementary and Alternative Medicine - June 13, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Fermented Citrus Lemon Reduces Liver Injury Induced by Carbon Tetrachloride in Rats.
Authors: Chen YJL, Chou PC, Hsu CL, Hung JF, Wu YC, Lin JG Abstract Fermented lemon juice displays a variety of important biological activities, including anti-inflammatory and antioxidant capabilities. The aim of the present study is to investigate hepatic-protective effects of no-sugar-added fermented lemon juice (FLJ) for liver inflammation caused by carbon tetrachloride (CCl4) in rats. Rats are divided into six groups: H2O, CCl4 + H2O, CCl4 + silymarin, and CCl4 plus three different FLJ doses by oral administration, respectively. The results show that the contents of plasma ALT and AST, hepatic lipid peroxidati...
Source: Evidence-based Complementary and Alternative Medicine - June 13, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

A Comparative Study of Melissa officinalis Leaves and Stems Ethanolic Extracts in terms of Antioxidant, Cytotoxic, and Antiproliferative Potential.
This study aimed to compare two M. officinalis ethanolic extracts, obtained from leaves and stems, with regard to their antioxidant activity, total phenolic content, and cytotoxic effects. M. officinalis ethanolic extracts showed a very good antioxidant activity in the DPPH test, correlated with the content in total phenols: higher in the case of M. officinalis from leaves extract (32.76 mg GAE/g) and lower for M. officinalis from stems extract (8.4 mg GAE/g). The lemon balm extracts exerted a cytotoxic effect on breast cancer cells (MDA-MB-231) even at low concentrations (100 μg/mL), ...
Source: Evidence-based Complementary and Alternative Medicine - June 13, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Therapeutic Potential of Pterostilbene and Resveratrol on Biomechanic, Biochemical, and Histological Parameters in Streptozotocin-Induced Diabetic Rats.
Conclusion: According to the findings, we suggest that these antioxidant treatments might have good therapeutic nutraceutical potential for some muscle diseases that coexist with diabetes. These treatments should be comprehensively investigated in the future. PMID: 29887910 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - June 13, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Scutellaria baicalensis Attenuates Airway Remodeling via PI3K/Akt/NF- κB Pathway in Cigarette Smoke Mediated-COPD Rats Model.
Conclusions. SB could significantly improve the condition of airway remodeling by inhibiting airway inflammation and partially quenching TGF-β and MMPs via PI3K/AKT/NF-κB pathway. PMID: 29861765 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - June 6, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Acupuncture Compared with Intramuscular Injection of Neostigmine for Postpartum Urinary Retention: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Conclusion: Acupuncture alone is more effective in treating postpartum urinary retention than intramuscular injection of neostigmine, with good safety profile. Therefore, it is a feasible and valuable technique in clinical settings. PMID: 29861766 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - June 6, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Ayurvedic Medicine for the Treatment of Dementia: Mechanistic Aspects.
Authors: Farooqui AA, Farooqui T, Madan A, Ong JH, Ong WY Abstract Ayurvedic medicine is a personalized system of traditional medicine native to India and the Indian subcontinent. It is based on a holistic view of treatment which promotes and supports equilibrium in different aspects of human life: the body, mind, and soul. Popular Ayurvedic medicinal plants and formulations that are used to slow down brain aging and enhance memory include Ashwagandha (Withania somnifera), Turmeric (Curcuma longa), Brahmi (Bacopa monnieri), Shankhpushpi (Convolvulus pluricaulis, Evolvulus alsinoides, and other species), gotu kola (...
Source: Evidence-based Complementary and Alternative Medicine - June 6, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Effects of Panax ginseng on Obesity in Animal Models: A Systematic Review and Meta-Analysis.
Authors: Park HS, Cho JH, Kim KW, Chung WS, Song MY Abstract Objective: To determine the antiobesity effects of Panax ginseng in animals. Methods: We conducted a systematic search for all controlled trials (up to March 2017) that assessed the antiobesity effects of P. ginseng in animal obesity models in the PubMed, EMBASE, Cochrane library, Web of Science, and Scopus databases. The primary outcome was final body weight measured at the longest follow-up time after administration of the intervention. The secondary outcome was the lipid profile. We assessed methodological quality using the SYRCLE risk of bias tool...
Source: Evidence-based Complementary and Alternative Medicine - June 6, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Mindfulness Meditation Targets Transdiagnostic Symptoms Implicated in Stress-Related Disorders: Understanding Relationships between Changes in Mindfulness, Sleep Quality, and Physical Symptoms.
Authors: Greeson JM, Zarrin H, Smoski MJ, Brantley JG, Lynch TR, Webber DM, Hall MH, Suarez EC, Wolever RQ Abstract Mindfulness-Based Stress Reduction (MBSR) is an 8-week meditation program known to improve anxiety, depression, and psychological well-being. Other health-related effects, such as sleep quality, are less well established, as are the psychological processes associated with therapeutic change. This prospective, observational study (n = 213) aimed to determine whether perseverative cognition, indicated by rumination and intrusive thoughts, and emotion regulation, measured by avoidance, thought suppressio...
Source: Evidence-based Complementary and Alternative Medicine - June 6, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Research Progress in the Effect of Traditional Chinese Medicine for Invigoration on Neurotransmitter Related Diseases.
Authors: Zhang X, Li L, Chen T, Sun Z, Tang W, Wang S, Wang T, Wang Y, Zhang H Abstract Tonic traditional Chinese medicine is widely used in clinical practice and is categorized into four main drugs, namely, Qi-supplementing, Blood-enriching, Yin-nourishing, and Yang-tonifying. Neurotransmitters play a coordinating role in the nervous system, visceral function, and stress response. The excitation or suppression of the central nervous system is closely related to various diseases, such as insomnia, depression, Alzheimer's disease, Parkinson's disease, and perimenopausal syndrome. An increasing amount of evidence sho...
Source: Evidence-based Complementary and Alternative Medicine - June 6, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Systems Pharmacology Dissection of Traditional Chinese Medicine Wen-Dan Decoction for Treatment of Cardiovascular Diseases.
In this study, a system pharmacology approach was developed to reveal the underlying molecular mechanisms of a clinically effective herb formula (Wen-Dan Decoction) in treating CVDs. 127 potential active compounds and their corresponding 283 direct targets were identified in Wen-Dan Decoction. The networks among active compounds, targets, and diseases were built to reveal the pharmacological mechanisms of Wen-Dan Decoction. A "CVDs pathway" consisted of several regulatory modules participating in therapeutic effects of Wen-Dan Decoction in CVDs. All the data demonstrates that Wen-Dan Decoction has multiscale bene...
Source: Evidence-based Complementary and Alternative Medicine - June 6, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

The Role of Semipurified Fractions Isolated from Quercus infectoria on Bone Metabolism by Using hFOB 1.19 Human Fetal Osteoblast Cell Model.
Conclusions. These findings demonstrated that polyphenols from semipurified fractions of QI enhanced bone formation through expression of the investigated bone-related marker that is its potential role when combined with readily available osteoporotic drug. PMID: 29861772 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - June 6, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

The Flavonoid Jaceosidin from Artemisia princeps Induces Apoptotic Cell Death and Inhibits the Akt Pathway in Oral Cancer Cells.
In this study, we investigated the effects of jaceosidin in oral squamous cell carcinoma (OSCC) cells and initially showed selective suppression of proliferation (IC50 = 82.1 μM in HSC-3 cells and 97.5 μM in Ca9.22 cells) and accumulation of cells at the sub-G1 stage of the cell cycle. In addition, jaceosidin increased cleavage of caspase-9 and caspase-3 in OSCC cells, although caspase-8 was not detected. In further experiments, jaceosidin downregulated Akt phosphorylation and ectopic activation of Akt blocked the antiproliferative effects of jaceosidin. Finally, we showed that jaceosidin has no effects...
Source: Evidence-based Complementary and Alternative Medicine - June 6, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Ganoderma lucidum and Auricularia polytricha Mushrooms Protect against Carbofuran-Induced Toxicity in Rats.
Authors: Hossen MS, Billah Prince MM, Tanvir EM, Chowdhury MAZ, Rahman MA, Alam F, Paul S, Saha M, Ali MY, Bhoumik NC, Karim N, Gan SH, Khalil MI Abstract The current study aimed to investigate the ameliorative effects of two types of mushrooms, Ganoderma lucidum (GL) and Auricularia polytricha (AP), against carbofuran- (CF) induced toxicity in rats. Male Wistar rats (n = 42) were divided into six equal groups. The rats in the negative control group received oral administration of CF at 1 mg/kg with the normal diet for 28 days. The treatment groups received oral administration of ethanolic extract of GL or A...
Source: Evidence-based Complementary and Alternative Medicine - June 6, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

The Comprehensive Therapy of Electroacupuncture Promotes Regeneration of Nerve Fibers and Motor Function Recovery in Rats after Spinal Cord Injury.
Authors: Li YF, Li T, Zhang DW, Xue H, Chen D, Li C, Wang FC Abstract The present study aimed to evaluate the role of the combination treatment of methylprednisolone (MP) and electroacupuncture (EA) in regeneration of nerve fibers and functional recovery in rats with spinal cord injury (SCI). Female Wistar rats were used for an SCI model by using a weight-drop hammer at levels T10 (spinal cord segment corresponding to the 10th thoracic vertebra). Four groups received different treatments for the study: SCI control, MP, MP and EA, and Sham. The growth of nerve fibers was examined by counting fluorescein positive ner...
Source: Evidence-based Complementary and Alternative Medicine - June 6, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Cytotoxic Activity of Extracts from Plants of Central Argentina on Sensitive and Multidrug-Resistant Leukemia Cells: Isolation of an Active Principle from Gaillardia megapotamica.
Authors: González ML, Joray MB, Laiolo J, Crespo MI, Palacios SM, Ruiz GM, Carpinella MC Abstract Plants are a significant reservoir of cytotoxic agents, including compounds with the ability to interfere with multidrug-resistant (MDR) cells. With the aim of finding promising candidates for chemotherapy, 91 native and naturalized plants collected from the central region of Argentina were screened for their cytotoxic effect toward sensitive and MDR P-glycoprotein (P-gp) overexpressing human leukemia cells by means of MTT assays. The ethanol extracts obtained from Aldama tucumanensis, Ambrosia elatior, Bacchari...
Source: Evidence-based Complementary and Alternative Medicine - June 6, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Vaccinium macrocarpon Aiton Extract Ameliorates Inflammation and Hyperalgesia through Oxidative Stress Inhibition in Experimental Acute Pancreatitis.
Authors: Santana DG, Oliveira AS, Souza MTS, Santos JTDC, Hassimotto NMA, Silva AMOE, Grespan R, Camargo EA Abstract We evaluated the effect of the hydroethanolic extract of fruits of Vaccinium macrocarpon (HEVm) in a model of acute pancreatitis (AP) in mice. AP was induced by two injections of L-arginine and animals were treated with HEVm (50, 100, and 200 mg/kg, p.o.) or vehicle (saline) every 24 h, starting 1 h after the induction of AP. Phytochemical analysis of the extract and measurement of inflammatory and oxidative stress parameters, as well as abdominal hyperalgesia, were performed. Ca...
Source: Evidence-based Complementary and Alternative Medicine - June 6, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Prevention of Prostate Tumor Development by Stimulation of Antitumor Immunity Using a Standardized Herbal Extract (Deep Immune ®) in TRAMP Mice.
In conclusion, daily intake of DI prevents PCa progression in TRAMP mice, suggesting the possible effectiveness of the immunostimulant herbal products on prevention of PCa progression after diagnosis of low-risk PCa. PMID: 29861778 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - June 6, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Erratum to "Therapeutic Effectiveness and Safety of Mesotherapy in Patients with Osteoarthritis of the Knee".
Erratum to "Therapeutic Effectiveness and Safety of Mesotherapy in Patients with Osteoarthritis of the Knee". Evid Based Complement Alternat Med. 2018;2018:5327589 Authors: Chen L, Li D, Zhong J, Qiu B, Wu X Abstract [This corrects the article DOI: 10.1155/2018/6513049.]. PMID: 29863186 [PubMed - in process] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - June 6, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Heart Protective Effects of Electroacupuncture in an Animal Experimental Study with Delayed Fluid Resuscitation after Hemorrhagic Shock.
Authors: Wang H, Liu Z, Liu Y, Tong Z, Qian Y, Chen L, Jiang B, Lin M, Yang T, Gao L, Chen M, Litscher D, Wang L, Litscher G Abstract Fluid resuscitation could hardly be performed immediately after fatal hemorrhagic shock in outpatients. We investigated whether electroacupuncture (EA) at Zusanli (ST36) could prevent fatal hemorrhagic shock induced heart failure with delayed fluid resuscitation and whether the protective role of EA is related to the autonomic nervous system. Sixty Sprague Dawley rats were randomly divided into five groups (n = 12 each): group of sham hemorrhagic shock (SHAM), group of EA, group of s...
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Acute Physiological and Psychological Effects of Qigong Exercise in Older Practitioners.
This study evaluated the acute physiological and psychological effects of one session of qigong exercise in older practitioners. A total of 45 participants (mean age, 65.14 years) were recruited. Meridian electrical conductance, State-Trait Anxiety Inventory (STAI), heart rate variability (HRV), and Short Form 36 (SF-36) were evaluated and compared before and after one session of qigong exercise. The results revealed that the electrical conductance of all meridians, except spleen and bladder meridians, increased significantly (p
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Natural Products for the Prevention and Treatment of Chronic Inflammatory Diseases: Integrating Traditional Medicine into Modern Chronic Diseases Care.
Authors: Kim JH, Kismali G, Gupta SC PMID: 29805468 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Corrigendum to "Antioxidant Activity of a Geopropolis from Northeast Brazil: Chemical Characterization and Likely Botanical Origin".
Corrigendum to "Antioxidant Activity of a Geopropolis from Northeast Brazil: Chemical Characterization and Likely Botanical Origin". Evid Based Complement Alternat Med. 2018;2018:7084284 Authors: Ferreira JM, Fernandes-Silva CC, Salatino A, Message D, Negri G Abstract [This corrects the article DOI: 10.1155/2017/4024721.]. PMID: 29849190 [PubMed - in process] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

The Effect of Electroacupuncture versus Manual Acupuncture through the Expression of TrkB/NF- κB in the Subgranular Zone of the Dentate Gyrus of Telomerase-Deficient Mice.
The Effect of Electroacupuncture versus Manual Acupuncture through the Expression of TrkB/NF-κB in the Subgranular Zone of the Dentate Gyrus of Telomerase-Deficient Mice. Evid Based Complement Alternat Med. 2018;2018:1013978 Authors: Lin D, Zhang J, Zhuang W, Yan X, Yang X, Lin S, Lin L Abstract Our previous study showed that the acupuncture stimulation on the acupoint (ST-36) could activate the brain-derived neurotropic factor (BDNF) signaling pathways in telomerase-deficient mice. Recently, we set out to investigate whether the manual acupuncture (MA) or electroacupuncture (EA) displays a thera...
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Glehnia littoralis Root Extract Inhibits Fat Accumulation in 3T3-L1 Cells and High-Fat Diet-Induced Obese Mice by Downregulating Adipogenic Gene Expression.
This study was conducted to investigate the effects of Glehnia littoralis root hot water extract (GLE) and its underlying mechanism on 3T3-L1 cell adipogenesis and in high-fat diet- (HFD-) induced obese mice. We measured intracellular lipid accumulation using oil red O staining in vitro. For in vivo study, twenty-eight C57BL/6J male mice were randomly divided into four groups, Control, HFD, HFD + 1% GLE, and HFD + 5% GLE, which was performed for eight weeks. We determined the expression levels of the adipogenesis-related proteins by RT-PCR and western blotting in HFD-induced obese mice. The GLE dose-dependently inhibited 3...
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Clinical Effects of Regular Dry Sauna Bathing: A Systematic Review.
Authors: Hussain J, Cohen M Abstract Introduction: Many health benefits are claimed by individuals and facilities promoting sauna bathing; however the medical evidence to support these claims is not well established. This paper aims to systematically review recent research on the effects of repeated dry sauna interventions on human health. Methods: A systematic search was made of medical databases for studies reporting on the health effects of regular dry sauna bathing on humans from 2000 onwards. Risk of bias was assessed according to the Cochrane Collaboration guidelines. Results: Forty clinical studies i...
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Tiaolipiwei Acupuncture Reduces Albuminuria by Alleviating Podocyte Lesions in a Rat Model of Diabetic Nephropathy.
Conclusion: Our study suggests that Tiaolipiwei acupuncture ameliorates podocyte lesions to reduce albuminuria and prevent the progression of T2DN in a rat model. PMID: 29849693 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

The Traditional Medicinal Plants Cuphea calophylla, Tibouchina kingii, and Pseudelephantopus spiralis Attenuate Inflammatory and Oxidative Mediators.
This study aimed to elucidate the anti-inflammatory and cytoprotective effects of hydroalcoholic extracts from C. calophylla (HECC), T. kingii (HETK), and P. spiralis (HEPS) in LPS-stimulated THP-1 macrophages. Reactive oxygen species (ROS), nitric oxide (NO), and malondialdehyde (MDA) were monitored as inflammatory and oxidative markers. The inhibition of lipoxygenase (LOX) and cyclooxygenase (COX) activities in a cell-free system were also investigated. Antioxidant activities were determined using standard in vitro methods. All extracts inhibited the NO, ROS, and MDA levels. HETK showed the highest ROS production inhibit...
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Correlation between Traditional Chinese Medicine Symptom Patterns and the Renal Function, Immunologic Function Index, and Blood Coagulation Index in Patients with Henoch-Sch önlein Purpura Nephritis.
Conclusion: We analyzed and summarized the clinical characteristics of patients with HSPN and found that dampness-heat accumulation was dominant in patients and was always accompanied by immune disorders and coagulation disorders. These results provided the largest therapeutic effects of Chinese herbs decoction for clinical treatment. PMID: 29849695 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Toxicity, Phytochemical Composition, and Enzyme Inhibitory Activities of Some Indigenous Weed Plant Extracts in Fruit Fly, Drosophila melanogaster.
Authors: Riaz B, Zahoor MK, Zahoor MA, Majeed HN, Javed I, Ahmad A, Jabeen F, Zulhussnain M, Sultana K Abstract Drosophila melanogaster being used as model organism is considered as pest of homes, restaurants, and fruit markets. The damaged fruits are also reported to serve as a carrier for various diseases. The current study was designed to evaluate the toxicity of petroleum extract of some weed plants, namely, Euphorbia prostrata, Parthenium hysterophorus, Fumaria indica, Chenopodium murale, and Azadirachta indica, against D. melanogaster. Mortality at 10, 20, and 30% concentrations after 24 and 48 hours was foun...
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Which Benefits and Harms of Using Fenugreek as a Galactogogue Need to Be Discussed during Clinical Consultations? A Delphi Study among Breastfeeding Women, Gynecologists, Pediatricians, Family Physicians, Lactation Consultants, and Pharmacists.
Conclusion: Probably, potential harms and benefits of recommending fenugreek as herbal galactogogue for breastfeeding women seeking recommendations to increase their human milk supply need to be discussed during clinical consultations. Further observational studies are needed to assess what is being discussed in daily consultations when herbal remedies are recommended. PMID: 29849697 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Efficacy and Safety of Tripterygium Wilfordii Hook F on Psoriasis Vulgaris: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Authors: Lv M, Deng J, Tang N, Zeng Y, Lu C Abstract Background: Psoriasis is a chronic autoimmune-mediated skin disease that is characterized by persistent localized erythematous scaly plaque. Tripterygium wilfordii Hook F (TwHF), a well-known Chinese medicine that has been used for centuries in China to treat immune diseases, inflammation, and tumor, is accompanied by a degree of toxic effects. Its clinical efficacy and safety on psoriasis are incompletely understood. Aim: To summarize evidence concerning the efficacy and safety of TwHF in treating psoriasis. Methods. EMBASE, Ovid MEDLINE, PubMed, Web of Scie...
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Experimental Study of Phlebitis Ointment Administration in Acute Superficial Thrombophlebitis.
Authors: Li G, Litscher G, Pang H, Yang B, Litscher D, Wang L Abstract Acute superficial thrombophlebitis is a venous system disease. Animal models with mannitol induced phlebitis were treated with an orally administered "phlebitis ointment." 24 rabbits were randomly divided into 4 groups. The therapy group was treated with "phlebitis ointment" and a control group received "Mai Luo Shu Tong granules." Levels of blood TNF-α, IL-6, CRP, and IL-1β were measured. The tissue expression levels of NF-КBp65 and PKC genes were evaluated. The therapy group showed a better improvement...
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Natural Products as an Emerging Therapeutic Alternative in the Treatment of Neurological Disorders.
Authors: Karim N, Abdelhalim H, Gavande N, Khan I, Khan H PMID: 29849700 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Multiple Bioactivities of Traditional Medicinal Herbs for Treatment of Neurodegenerative Diseases.
Authors: Park G, Kusuma IW, Kim YU PMID: 29849701 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Effect of Allicin against Ischemia/Hypoxia-Induced H9c2 Myoblast Apoptosis via eNOS/NO Pathway-Mediated Antioxidant Activity.
Authors: Ma L, Chen S, Li S, Deng L, Li Y, Li H Abstract Allicin (2-propene-1-sulfinothioic acid S-2-propenyl ester, diallyl thiosulfinate) is the main biologically active ingredient in garlic. The present study investigated the protective effect of allicin against cardiomyocyte apoptosis that was induced by ischemia in vitro and the potential molecular mechanisms that were involved in this antiapoptotic effect. The results indicated that allicin increased H9c2 cell activity and attenuated the rate of apoptosis that was induced by ischemia/hypoxia. Intracellular calcium concentrations significantly decreased in the...
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Extraction of Polysaccharide from Spirulina and Evaluation of Its Activities.
Conclusion: An extraction method for high-purity PSP with a high extraction rate was established, and in vitro results suggest antioxidation and antiaging activities. PMID: 29849703 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

The Synergy and Mode of Action of Cyperus rotundus L. Extract Plus Ampicillin against Ampicillin-Resistant Staphylococcus aureus.
This study aimed to determine the antibacterial activity and mode of actions of Cyperus rotundus extract (CRE) against ampicillin-resistant Staphylococcus aureus (ARSA) which poses a serious problem for hospitalized patients. The majority of chemical compounds of CRE were flavonoids and alkaloids. The minimum inhibitory concentrations (MICs) for ampicillin and CRE against all ARSA strains were 64 μg/ml and 0.5 mg/ml, respectively. Checkerboard assay revealed synergistic activity in the combination of ampicillin and CRE at the lowest fractional inhibitory concentration index (FICI) at 0.27. The killing curv...
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Renoprotective Effect of Danhong Injection on Streptozotocin-Induced Diabetic Rats through a Peroxisome Proliferator-Activated Receptor γ Mediated Pathway.
Renoprotective Effect of Danhong Injection on Streptozotocin-Induced Diabetic Rats through a Peroxisome Proliferator-Activated Receptor γ Mediated Pathway. Evid Based Complement Alternat Med. 2018;2018:3450141 Authors: Yang X, Xiao X, Wang H, Li Y, Wang L, Li G, Deng S Abstract The aim of the study was to investigate the protective effect of Danhong injection (DHI) on diabetic kidney disease and explore the potential mechanisms. Diabetic kidney disease was induced by unilateral nephrectomy, high-fat diet, and streptozotocin. After DHI administration, the renal function deterioration, 24-hour tota...
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Modulation of Neuronal Activity on Intercalated Neurons of Amygdala Might Underlie Anxiolytic Activity of a Standardized Extract of Centella asiatica ECa233.
Authors: Wanasuntronwong A, Wanakhachornkrai O, Phongphanphanee P, Isa T, Tantisira B, Tantisira MH Abstract GABAergic intercalated neurons of amygdala (ITCs) have recently been shown to be important in the suppression of fear-like behavior. Effects of ECa233 (a standardized extract of Centella asiatica), previously demonstrated anxiolytic activity, were then investigated on ITCs. Cluster of GABAergic neurons expressing fluorescence of GFP was identified in GAD67-GFP knock-in mice. We found that neurons of medial paracapsular ITC were GABAergic neurons exhibiting certain intrinsic electrophysiological properties si...
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Acupuncture at Tiaokou (ST38) for Shoulder Adhesive Capsulitis: What Strengths Does It Have? A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Conclusion: Our review found encouraging evidence for the effectiveness of acupuncture at Tiaokou for SAC. Nonetheless, despite stringent methodological analyses, these results need to be strengthened by additional RCTs of higher quality. PMID: 29849707 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

A Randomized Controlled Trial of Chinese Patent Medicine Xiao'er Biantong Granules in the Treatment of Functional Constipation in Children.
Conclusions: Xiao'er Biantong granules have superior efficacy compared to the placebo for the treatment of functional constipation in children and are well tolerated. PMID: 29849708 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

DNA Barcoding for the Identification and Authentication of Animal Species in Traditional Medicine.
Authors: Yang F, Ding F, Chen H, He M, Zhu S, Ma X, Jiang L, Li H Abstract Animal-based traditional medicine not only plays a significant role in therapeutic practices worldwide but also provides a potential compound library for drug discovery. However, persistent hunting and illegal trade markedly threaten numerous medicinal animal species, and increasing demand further provokes the emergence of various adulterants. As the conventional methods are difficult and time-consuming to detect processed products or identify animal species with similar morphology, developing novel authentication methods for animal-based tr...
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Anti-Inflammatory Effects of Berberine Hydrochloride in an LPS-Induced Murine Model of Mastitis.
In this study, a lipopolysaccharide- (LPS-) induced murine model of mastitis was established to explore the anti-inflammatory action of berberine hydrochloride. Sixty mice that had been lactating for 5-7 days were randomly divided into six groups, including control, LPS, three berberine hydrochloride treatment groups (5, 10, and 20 mg/kg), and a dexamethasone (DEX) (5 mg/kg) group. Berberine hydrochloride was administered intraperitoneally 1 h before and 12 h after LPS-induced mastitis, and all mice were sacrificed 24 h after LPS induction. The pathological and histopathological changes o...
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Mechanisms of Antiulcer Effect of an Active Ingredient Group of Modified Xiao Chaihu Decoction.
Authors: Liu W, Yang M, Chen X, Li L, Zhou A, Chen S, You P, Liu Y Abstract The present study aimed to investigate the antiulcer activities and mechanisms of action of an active ingredient group (AIG) of Modified Xiao Chaihu Decoction (MXCD). The gastroprotective action of the AIG was studied in ethanol-induced, pylorus ligature-induced, and acetic acid-induced in vivo gastric ulcer models. The enzyme-linked immunoadsorbent assay (tumor necrosis factor-α (TNF-α), prostaglandin E2 (PGE2), and epidermal growth factor (EGF)), nitrate reductase assay (nitric oxide (NO)), western blot analysis (Bax, Bcl-2, c...
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Effects of Gui Zhi Ma Huang Ge Ban Tang on the TLR7 Pathway in Influenza Virus Infected Mouse Lungs in a Cold Environment.
Conclusions: Gui Zhi Ma Huang Ge Ban Tang had a good therapeutic effect on mice infected with IAV, especially in the cold environment. It could reduce lung inflammation in mice significantly and elicit an anti-influenza effect by downregulating expression of the key factors in TLR7 signaling pathway. PMID: 29849712 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Immunomodulatory Effects of Kuseonwangdogo-Based Mixed Herbal Formula Extracts on a Cyclophosphamide-Induced Immunosuppression Mouse Model.
Conclusion: MHFe can be a promising, potent immunomodulatory therapeutic agent for various immune disorders. PMID: 29849713 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

The Traditional Chinese Medicine Kangai Injection as an Adjuvant Method in Combination with Chemotherapy for the Treatment of Breast Cancer in Chinese Patients: A Meta-Analysis.
Conclusion: Kangai injection as an adjuvant method in combination with chemotherapy for treating Chinese breast cancer patients can improve their life quality and physical conditions and reduce the adverse reactions that result from chemotherapy. However, the present conclusion is only suitable for the Chinese population. The long-term, high-quality researches are required to further verify the above conclusions. PMID: 29849714 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Aster koraiensis Extract and Chlorogenic Acid Inhibit Retinal Angiogenesis in a Mouse Model of Oxygen-Induced Retinopathy.
In this study, we aimed to evaluate the effects of AKE and CA on retinal neovascularization in a mouse model of oxygen-induced retinopathy (OIR). Vascular endothelial growth factor- (VEGF-) induced tube formation was assayed in human vascular endothelial cells. Experimental retinal neovascularization was induced by exposing C57BL/6 mice to 75% oxygen on postnatal day 7 (P7) and then returning them to normal oxygen pressure on P12. AKE (25 and 50 mg/kg/day) and CA (25 and 50 mg/kg/day) were administered intraperitoneally for 5 days (P12-P16). Retinal flat mounts were prepared to measure the extent of retinal n...
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

The Effects of Acupuncture Combined with Auricular Acupressure in the Treatment of Chloasma.
Authors: Wu X, Xiang Y Abstract Objective: To investigate the effectiveness of acupuncture combined with auricular acupressure in chloasma treatment. Methods: A prospective, randomized controlled assessor-blind clinical trial was performed and 135 patients were assigned into acupuncture combined with auricular acupressure (A), acupuncture (B), and control (C) groups, each with 45 patients. For groups A and B, body and facial acupuncture were applied for 2 months. For group A, auricular acupressure was applied concomitantly. For group C, vitamins C and E were prescribed for 3 months. Primary outcome measure was ...
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research