Community Pharmacists' Knowledge, Attitudes, and Practice of Herbal Medicines in Asir Region, Kingdom of Saudi Arabia.
This study aimed to evaluate community pharmacists' knowledge, attitudes, and practices of herbal medicines in the Asir region, Saudi Arabia. Methods: An online cross-sectional study was conducted among 233 community pharmacists using a structured questionnaire. Results: Pharmacists showed considerable knowledge of the indications of herbal products, with an average score of 84% correct answers, total P value
Source: Evidence-based Complementary and Alternative Medicine - September 21, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Complementary and Alternative Therapies for Inflammatory Diseases 2018.
Authors: Lin YJ, Xu Y, Xu J PMID: 30228825 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - September 21, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Single Oral Acute Toxicity of Banhasasim-Tang and Its Antiobesity Effect on Diet-Induced Obese Mice and 3T3-L1 Adipocytes.
Authors: Yoo SR, Jeong SJ, Lee MY, Shin HK, Seo CS, Ha H Abstract We had tested antiobesity effect of 52 traditional herbal formulas in 3T3-L1 adipocyte, and Banhasasim-tang (BHSST) was chosen as one of the effective medications to inhibit triglyceride accumulation. We investigated the antiobesity effect of BHSST on 3T3-L1 adipocytes and high-fat diet- (HFD-) induced obese mice. In addition, we evaluated the acute toxicity of BHSST in Sprague Dawley (SD) rats. Differentiated 3T3-L1 cells were treated with various concentrations of BHSST for 8 days. Accumulated triglyceride level and the expressions of adipogenesis-...
Source: Evidence-based Complementary and Alternative Medicine - September 21, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Association Rule Analysis for Validating Interrelationships of Combined Medication of Compound Kushen Injection in Treating Colon Carcinoma: A Hospital Information System-Based Real-World Study.
Conclusions: It is a common practice for CKI to be integrated with both modern medicines and TCMs when treating CC in China. The associations of medication combinations of CKI in treating CC manifest certain laws for both TCMs and modern medicines. The RWS for validating interrelationships of combined medication may provide evidence for rational use of CKI. Further explorations are needed to verify and expand the conclusions. PMID: 30228827 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - September 21, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Antioxidant Activity and In Vitro Antiglycation of the Fruit of Spondias purpurea.
Authors: Muñiz A, Garcia E, Gonzalez D, Zuñiga L Abstract Hyperglycemia in diabetes mellitus causes irreversible life-threatening micro- and macrovascular complications. There is evidence that the glycation reaction leads to a chemical modification of the proteins contributing to the complications of diabetes. It is known that advanced glycation end products (AGEs) are formed by glycation and oxidation reactions called glycoxidation. CML, a nonfluorescent AGE, has become a biomarker of glycoxidative damage; other AGEs appear to induce oxidative stress, which results in cytotoxicity. To determine antio...
Source: Evidence-based Complementary and Alternative Medicine - September 21, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Inhibition of α-Glucosidase, Intestinal Glucose Absorption, and Antidiabetic Properties by Caralluma europaea.
Inhibition of α-Glucosidase, Intestinal Glucose Absorption, and Antidiabetic Properties by Caralluma europaea. Evid Based Complement Alternat Med. 2018;2018:9589472 Authors: Ouassou H, Zahidi T, Bouknana S, Bouhrim M, Mekhfi H, Ziyyat A, Legssyer A, Aziz M, Bnouham M Abstract Many medicinal plants around the world are used for therapeutic purposes against several diseases, including diabetes mellitus. Due to their composition of natural substances that are effective and do not represent side effects for users, unlike synthetic drugs, in this study, we investigated the inhibitory effect of Carallu...
Source: Evidence-based Complementary and Alternative Medicine - September 21, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

SYKT Alleviates Doxorubicin-Induced Cardiotoxicity via Modulating ROS-Mediated p53 and MAPK Signal Pathways.
Conclusions. Our results indicated that SYKT alleviated DOX-induced cardiotoxicity by inhibiting p53 and MAPK signal pathways' activation-mediated apoptosis, and it might serve as a potential therapeutic agent for DOX-induced cardiotoxicity. PMID: 30224925 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - September 20, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Clinical Evaluation of Herbal Medicine (ICH-012) in Treating Acute Cerebral Haemorrhage: Safety and Efficacy from 6- to 72-Hour Time Window (CRRICHTrial-II).
Discussion: A large amount of data from high-quality RCTs is needed for the extensive clinical application of herbal medicine. The CRRICHTrial-II will evaluate the safety and effectiveness of ICH-012 in a safer time window between 6 and 72 h and investigate the possible mechanisms of action and direction of herbal medicine in the haematoma growth after HICH. Trial registration at ClinicalTrial.gov, ID: NCT03354026, is registered on 23rd Nov. 2017. PMID: 30224926 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - September 20, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Bushen-Yizhi Formula Alleviates Neuroinflammation via Inhibiting NLRP3 Inflammasome Activation in a Mouse Model of Parkinson's Disease.
Authors: Mo Y, Xu E, Wei R, Le B, Song L, Li D, Chen Y, Ji X, Fang S, Shen J, Yang C, Wang Q Abstract Parkinson's disease (PD), the second most common neurodegenerative disease, is characterized by the progressive loss of dopaminergic neurons in the substantia nigra. Although the molecular mechanisms underlying dopaminergic neuronal degeneration in PD remain unclear, neuroinflammation is considered as the vital mediator in the pathogenesis and progression of PD. Bushen-Yizhi Formula (BSYZ), a traditional Chinese medicine, has been demonstrated to exert antineuroinflammation in our previous studies. However, it rema...
Source: Evidence-based Complementary and Alternative Medicine - September 20, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Adjuvant Therapy Using Mistletoe Containing Drugs Boosts the T-Cell-Mediated Killing of Glioma Cells and Prolongs the Survival of Glioma Bearing Mice.
Authors: Schötterl S, Huber SM, Lentzen H, Mittelbronn M, Naumann U Abstract Viscum album L. extracts (VE) are applied as complementary cancer therapeutics for more than one century. Extracts contain several compounds like mistletoe lectins (ML) 1-3 and viscotoxins, but also several minor ingredients. Since ML-1 has been described as one of the main active components harboring antitumor activity, purified native or recombinant ML-1 has been also used in clinical trials in the last years. The present study examined and compared the immunoboosting effects of three ML-1 containing drugs (the extract ISCADOR Qu, t...
Source: Evidence-based Complementary and Alternative Medicine - September 20, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Difference between Right and Left Facial Surface Electromyography in Healthy People.
Conclusions: It could provide basic data for the future diagnosis of facial nerve palsy patients by measuring facial sEMG values for healthy people. PMID: 30224929 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - September 20, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Safety and Efficacy of Ferula asafoetida in Functional Dyspepsia: A Randomized, Double-Blinded, Placebo-Controlled Study.
Authors: Mala KN, Thomas J, Syam DS, Maliakel B, Krishnakumar IM Abstract Despite the availability of various synthetic drugs for the treatment of functional dyspepsia (FD), the side effects and their cost have always created a great interest in the search for novel natural alternatives for the management of gut disorders. The present contribution reports the safety and efficacy of the kitchen spice asafoetida (Ferula asafoetida) in FD for the first time. In the double-blinded, placebo-controlled study, 43 subjects diagnosed to have moderate to severe discomforts of nonulcer FD were randomized to receive hard-shell...
Source: Evidence-based Complementary and Alternative Medicine - September 20, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Investigation of Lake H évíz Mineral Water Balneotherapy and Hévíz Mud Treatment in Murine Osteoarthritis and Rheumatoid Arthritis Models.
Investigation of Lake Hévíz Mineral Water Balneotherapy and Hévíz Mud Treatment in Murine Osteoarthritis and Rheumatoid Arthritis Models. Evid Based Complement Alternat Med. 2018;2018:4816905 Authors: Tékus V, Borbély É, Kiss T, Perkecz A, Kemény Á, Horváth J, Kvarda A, Pintér E Abstract Arthritic diseases are the most frequent causes of chronic pain and disability. Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial inflammation and progressive structural joint damage. Osteoarthritis is a degenerative...
Source: Evidence-based Complementary and Alternative Medicine - September 20, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

"Diabetes and Metabolism Disorders Medicinal Plants: A Glance at the Past and a Look to the Future 2018": Antihyperglycemic Activity of Hamelia patens Jacq. Extracts.
"Diabetes and Metabolism Disorders Medicinal Plants: A Glance at the Past and a Look to the Future 2018": Antihyperglycemic Activity of Hamelia patens Jacq. Extracts. Evid Based Complement Alternat Med. 2018;2018:7926452 Authors: Rugerio-Escalona C, Ordaz-Pichardo C, Becerra-Martinez E, Cruz-López MDC, López-Y-López VE, Mendieta-Moctezuma A, Maldonado-Mendoza IE, Jiménez-Montejo FE Abstract Diabetes is one the world's most widespread diseases, affecting over 327 million people and causing about 300,000 deaths annually. Despite great advances in prevention and thera...
Source: Evidence-based Complementary and Alternative Medicine - September 20, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Protective Effects of Liu Wei Di Huang Wan on the Liver, Orbitofrontal Cortex Nissl Bodies, and Neurites in MSG+PH-Induced Liver Regeneration Rat Model.
Authors: Zhao BB, Long QH, Wang CY, Chen LL, Xie GJ, Bo WJ, Xu B, Li ZF, Li HM, Wang P Abstract Introduction. To examine the protective effects of Liu Wei Di Huang Wan formula (LWDH) on liver and orbitofrontal cortex (OFC) injuries in monosodium glutamate (MSG) and partial hepatectomy (PH) rat model. Methods. Neonatal Wistar rats were given MSG or saline on postnatal days 2, 4, 6, 8, and 10. The rats were caged into five groups and treated accordingly at six weeks old as follows: Saline group, Saline+PH group, MSG group, MSG+PH group, and LWDH group (MSG+PH+LWDH). The PH was performed during week 8 by excision of t...
Source: Evidence-based Complementary and Alternative Medicine - September 20, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Sirt1/Foxo Axis Plays a Crucial Role in the Mechanisms of Therapeutic Effects of Erzhi Pill in Ovariectomized Rats.
Authors: Liang W, Li X, Li G, Hu L, Ding S, Kang J, Shen J, Li C, Asakawa T Abstract Background. Erzhi pill (EZP), a traditional Chinese herbal formula, has been widely used to treat postmenopausal osteoporosis (PMOP) in China. However, its molecular mechanisms remain unclear. The aim of the present study is to investigate the antiosteoporotic effect of EZP on an ovariectomized rat model of PMOP. We performed the biomarkers of bone metabolism disorder, bone morphology, bone mineral density (BMD), and bone biomechanics to confirm the successful establishment of the PMOP model. We then investigated the expression of ...
Source: Evidence-based Complementary and Alternative Medicine - September 20, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Corrigendum to "The Effect of Sanggua Drink Extract on Insulin Resistance through the PI3K/AKT Signaling Pathway".
Corrigendum to "The Effect of Sanggua Drink Extract on Insulin Resistance through the PI3K/AKT Signaling Pathway". Evid Based Complement Alternat Med. 2018;2018:1404126 Authors: Cai Y, Wang Y, Zhi F, Xing QC, Chen YZ Abstract [This corrects the article DOI: 10.1155/2018/9407945.]. PMID: 30210569 [PubMed - in process] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - September 15, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Erzhi Formula Extracts Reverse Renal Injury in Diabetic Nephropathy Rats by Protecting the Renal Podocytes.
In this study, the main compounds of EZF and their pharmacokinetics in rat were detected by HPLC-MS/MS. And then, blood glucose, urine protein, renal index, renal microstructural (HE/PAS staining), inflammatory factors (IL-β, TNF-α, IL-6), and protein/mRNA expression related to the function of podocyte (CD2AP and Podocin) in DN rats were investigated after the oral administration of EZF. The concentrations of specnuezhenide and wedelolactone in rat kidney were 7.19 and 0.057 mg/kg, respectively. The Tmax of specnuezhenide and wedelolactone were 2.0 and 1.50 h, respectively. Their Cmax were, respectively, 30.24 &...
Source: Evidence-based Complementary and Alternative Medicine - September 15, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Therapeutic Efficacies of Artemisia capillaris Extract Cream Formulation in Imiquimod-Induced Psoriasis Models.
Authors: Lee SY, Nam S, Kim S, Koo JS, Hong IK, Kim H, Han S, Kang M, Yang H, Cho HJ Abstract A cream formulation containing Artemisia capillaris (AC) extract (ACE) was developed for psoriasis therapy. Although ACE can be dissolved in organic solvents, its topical application is restricted because of toxicities. Therefore, a cream formulation was developed for the convenient and safe local application of ACE on skin lesions. The antipsoriatic properties of the ACE cream were evaluated using an imiquimod- (IMQ-) induced psoriasis-like mouse model. In psoriasis-like mouse models, the cumulative score (redness, thickn...
Source: Evidence-based Complementary and Alternative Medicine - September 15, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Synergistic Effect of Bupleuri Radix and Scutellariae Radix on Adipogenesis and AMP-Activated Protein Kinase: A Network Pharmacological Approach.
In this study, we used the network pharmacological method to predict the interaction between these two herbs and then investigated the effects of BR, SR, and their combination on obesity in 3T3-L1 adipocytes. BR, SR, and BR-SR mixture significantly decreased lipid accumulation and the expressions of two major adipogenic factors, peroxisome proliferator-activated receptor-gamma (PPARγ) and CCAAT/enhancer-binding protein-alpha (C/EBPα), and their downstream genes, Adipoq, aP2, and Lipin1 in 3T3-L1 cells. In addition, the BR-SR mixture had synergistic effects compared with BR or SR on inhibition of adipogenic-gene...
Source: Evidence-based Complementary and Alternative Medicine - September 15, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

The Combination of Ephedrae herba and Coicis semen in Gambihwan Attenuates Obesity and Metabolic Syndrome in High-Fat Diet-Induced Obese Mice.
Authors: Jang JW, Lim DW, Chang JU, Kim JE Abstract Gambihwan is a herbal prescription used in Korean medicine to treat obesity. The authors evaluated the effects and mechanisms of two types of Gambihwan (GBH1 and 2) administered to high-fat diet- (HFD-) induced obese mice. Four-week-old C57BL/6 mice were fed a HFD for 8 weeks with or without GBH1 or 2 (100-200 mg/kg/day by oral gavage). All mice were subjected to glucose tolerance testing after the 8-week treatment period and then euthanized. Serum insulin, lipids, and inflammatory cytokine levels were analyzed using commercial kits. Hepatic enzyme levels and lipi...
Source: Evidence-based Complementary and Alternative Medicine - September 15, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Organic Extract of Justicia pectoralis Jacq. Leaf Inhibits Interferon- γ Secretion and Has Bacteriostatic Activity against Acinetobacter baumannii and Klebsiella pneumoniae.
Organic Extract of Justicia pectoralis Jacq. Leaf Inhibits Interferon-γ Secretion and Has Bacteriostatic Activity against Acinetobacter baumannii and Klebsiella pneumoniae. Evid Based Complement Alternat Med. 2018;2018:5762368 Authors: Nunes TRS, Cordeiro MF, Beserra FG, de Souza ML, da Silva WAV, Ferreira MRA, Soares LAL, Costa-Junior SD, Cavalcanti IMF, Pitta MGDR, Pitta IDR, Rêgo MJBM Abstract Justicia pectoralis Jacq. (Acanthaceae) leaves currently found in the Brazilian north-east are widely used to treat diabetes, menstrual pains, asthma, and other disorders. This work aimed to identi...
Source: Evidence-based Complementary and Alternative Medicine - September 15, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Inhibition of Aortic Intimal Hyperplasia and Vascular Smooth Muscle Proliferation and Extracellular Matrix Protein Expressions by Astragalus-Angelica Combination.
Authors: Yan H, Peng X, Xu H, Zhu J, Deng C Abstract VSMC proliferation and ECM deposition always resulted in intimal hyperplasia. Astragalus-Angelica combination has a protective effect on the cardiovascular system. The inhibition effect of different Astragalus-Angelica combination on the hyperplastic intima after vascular balloon injury in rats was investigated in this study. Astragalus-Angelica combination can inhibit the intima hyperplasia after balloon injury, in which a 1:1 ratio shows excellent results. Astragalus-Angelica combination can enhance the expression of smooth muscle α-actin (SMа-actin) and...
Source: Evidence-based Complementary and Alternative Medicine - September 8, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Cytotoxic Effect of Thymoquinone-Loaded Nanostructured Lipid Carrier (TQ-NLC) on Liver Cancer Cell Integrated with Hepatitis B Genome, Hep3B.
This study aims to determine the antiproliferative effects of TQ and TQ-NLC on liver cancer cells integrated with the hepatitis B genome, Hep3B. The Hep3B was treated with TQ or TQ-NLC for 24, 48, and 72 hours via MTT assay. The results confirm that TQ or TQ-NLC inhibited the growth of Hep3B at IC50
Source: Evidence-based Complementary and Alternative Medicine - September 8, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Effects of Tai Chi on Self-Efficacy: A Systematic Review.
Authors: Tong Y, Chai L, Lei S, Liu M, Yang L Abstract The purpose of this systematic review is to summarize and update the readers regarding clinical studies that have investigated the effects of Tai Chi on self-efficacy and to describe their limitations and biases. Nine electronic databases were searched from the establishment of the database until August 10, 2017. All randomized controlled trials (RCTs), nonrandomized controlled studies (NRSs), quasi-experimental studies, or studies with pre-post design were included if they clearly defined a Tai Chi intervention and evaluated self-efficacy outcomes. We categori...
Source: Evidence-based Complementary and Alternative Medicine - September 8, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Paeonol Ameliorates Ovalbumin-Induced Asthma through the Inhibition of TLR4/NF- κB and MAPK Signaling.
Paeonol Ameliorates Ovalbumin-Induced Asthma through the Inhibition of TLR4/NF-κB and MAPK Signaling. Evid Based Complement Alternat Med. 2018;2018:3063145 Authors: Tang Y, Huang W, Song Q, Zheng X, He R, Liu J Abstract Asthma is a chronic inflammatory disease of the airways, with complex signaling pathways involved in its pathogenesis. It was reported that paeonol attenuated airway inflammation of ovalbumin (OVA)-induced mice. Therefore, it is of importance to further investigate the underlying mechanism. BALB/c mice were challenged with OVA for the asthma model, which was validated by the chang...
Source: Evidence-based Complementary and Alternative Medicine - September 8, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Holistic Regulation of Angiogenesis with Chinese Herbal Medicines as a New Option for Coronary Artery Disease.
Authors: Yuan R, Shi WL, Xin QQ, Chen KJ, Cong WH Abstract Effectively improving myocardial blood flow and controlling atherosclerotic plaque have always been key and difficult points in the prevention and treatment of coronary artery disease (CAD). Although "therapeutic angiogenesis" is regarded as a promising approach for ischemic heart disease by improving blood flow, angiogenesis itself can induce the destabilization of atherosclerotic plaque, which reflects the double-edged role of angiogenesis. Modulating the balance of angiogenesis can be an important target for CAD treatment. Traditional Chinese m...
Source: Evidence-based Complementary and Alternative Medicine - September 8, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Intracoronary Glycoprotein IIb/IIIa Inhibitors Improve Short-Term Mortality and Reinfarction in East Asian Patients with ST-Segment Elevation Myocardial Infarction after Thrombus Aspiration: A Meta-Analysis.
Authors: Wu JH, Hao PP, Chen YG, Li RJ Abstract Objective: Intracoronary (IC) glycoprotein IIb/IIIa inhibitors (GPIs) after thrombus aspiration (TA) for patients with ST-segment elevation myocardial infarction (STEMI), as compared with percutaneous coronary interventions (PCI) alone, is still on debate. To address this issue, we performed a meta-analysis of results from prospective or randomized controlled trials on the topic. Methods: We searched electronic and printed sources (up to June 20, 2016) according to the selection criteria. Data were abstraction and meta-analysis was performed using RevMan 5.3 softw...
Source: Evidence-based Complementary and Alternative Medicine - September 8, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Effect of He's Santong Needling Method on Dysphagia after Stroke: A Study Protocol for a Prospective Randomized Controlled Pilot Trial.
Authors: Zhao L, Liu L, Zhang CS, Zeng L, Zhao J, Wang L, Jing X, Wang K, Li B Abstract Background: Dysphagia is a common complication of stroke, affecting up to 78% of stroke patients. The existence of dysphagia after stroke has been associated with an increased risk for pulmonary complications and even mortality. Previous studies have shown that acupuncture could be potential therapeutic method for treatment of dysphagia after stroke. A prospective randomized controlled pilot trial is designed to evaluate the effect of He's Santong needling method on dysphagia after stroke. Methods and Design: Sixty eligible ...
Source: Evidence-based Complementary and Alternative Medicine - September 8, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Effects of Juglans regia Root Bark Extract on Platelet Aggregation, Bleeding Time, and Plasmatic Coagulation: In Vitro and Ex Vivo Experiments.
Authors: Amirou A, Bnouham M, Legssyer A, Ziyyat A, Aziz M, Berrabah M, Mekhfi H Abstract Platelets have an important role in thrombosis and haemostasis. Hyperactivity of the platelets has been associated with thromboembolic diseases and represents the main cause of complications of cardiovascular diseases. Crude aqueous extract (CAE) of Juglans regia root bark was evaluated for bleeding time, antiaggregant activity by using agonists, thrombin, ADP, collagen, or arachidonic acid (in vitro and ex vivo), and anticoagulant activity by measuring the clotting parameters: activated partial thromboplastin time, prothrombi...
Source: Evidence-based Complementary and Alternative Medicine - September 8, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Effect of Edible Bird's Nest Extract on Lipopolysaccharide-Induced Impairment of Learning and Memory in Wistar Rats.
Authors: Careena S, Sani D, Tan SN, Lim CW, Hassan S, Norhafizah M, Kirby BP, Ideris A, Stanslas J, Bin Basri H, Lim CTS Abstract Cognitive disability is a common feature associated with a variety of neurological conditions including Alzheimer's Disease (AD), Parkinson's Disease (PD), brain injury, and stroke. Emerging evidence has demonstrated that neuroinflammation plays an important role in the development of cognitive impairment. Current available therapies are relatively ineffective in treating or preventing cognitive disabilities, thus representing an important, unfulfilled medical need. Hence, developing pot...
Source: Evidence-based Complementary and Alternative Medicine - September 8, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

The Effects of Andrographis paniculata on Platelet Activity in Healthy Thai Volunteers.
Conclusion. These controversial results are possibly due to the multifactorial mechanisms of platelet aggregation as well as the multichemical composition of AP. Further study, probably at the molecular level, is needed to unveil the underlying mechanisms of action of AP. PMID: 30174700 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - September 5, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Astilbe chinensis Modulates Platelet Function via Impaired MAPK and PLC γ2 Expression.
Conclusion: A. chinensis extract inhibited platelet aggregation and granule secretion and attenuated GPVI downstream signaling, indicating the potential therapeutic effects of this plant extract on the cardiovascular system and platelet function. We suggest that given plant extract may be a potent candidate to treat platelet-related CVDs and to be used as antiplatelet agent. PMID: 30174701 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - September 5, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

The Utilization of Medical Devices by Traditional Korean Medicine Doctors Investigated through Traditional Korean Medicine Clinical Studies.
Conclusions: This study suggests that TKM doctors use diagnostic information derived from modern medical devices clinically. It is therefore necessary to institutionalize considering changes to the medical acts of traditional medicine (TM) doctors. Additionally, this information can be utilized as a reference for developing TM policy and education. PMID: 30174702 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - September 5, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Effect of Orally Administered Atractylodes macrocephala Koidz Water Extract on Macrophage and T Cell Inflammatory Response in Mice.
Authors: Kwak TK, Jang HS, Lee MG, Jung YS, Kim DO, Kim YB, Kim JI, Kang H Abstract The rhizome of Atractylodes macrocephala Koidz (AM) is a constituent of various Qi booster compound prescriptions. We evaluated inflammatory responses in macrophages and T cells isolated from mice following oral administration of AM water extract (AME). Peritoneal exudate cells were isolated from thioglycollate-injected mice and alterations in scavenger receptors were examined. Peritoneal macrophages were stimulated with lipopolysaccharide (LPS). Serum cytokine responses to intraperitoneal LPS injection were also evaluated. Splenocy...
Source: Evidence-based Complementary and Alternative Medicine - September 5, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Effect of Bhramari Pranayama on the Acoustic and Aerodynamic Parameters of Voice in Normophonic Females.
Conclusion: Bhramari pranayama is effective in improving the acoustic and aerodynamic parameters of voice. The same needs to be investigated in hyper- and hypofunctional voice disorders in the future studies. PMID: 30174704 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - September 5, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Use of Chinese Herbal Medicine Improves Chemotherapy-Induced Thrombocytopenia among Gynecological Cancer Patients: An Observational Study.
Conclusions: The CGPEF is worthy of further large-scale, well-designed clinical trials for CIT among gynecological cancer patients. PMID: 30174705 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - September 5, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Protective Effect of Jianpiyifei II Granule against Chronic Obstructive Pulmonary Disease via NF- κB Signaling Pathway.
Protective Effect of Jianpiyifei II Granule against Chronic Obstructive Pulmonary Disease via NF-κB Signaling Pathway. Evid Based Complement Alternat Med. 2018;2018:4265790 Authors: Fan L, Chen R, Li L, Liang Z, Yu X, Huang K, Yin S, Wu L, Chen Y, Xu Y, Wang Q, Lin L Abstract Jianpiyifei II granule (JPYF II) is an oriental herbal formula used clinically in China to treat chronic obstructive pulmonary disease (COPD). The aim of the present study was to investigate the anti-inflammatory and antioxidative activities of JPYF II in a mouse model of COPD induced by lipopolysaccharide (LPS) and cigarett...
Source: Evidence-based Complementary and Alternative Medicine - September 5, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

A Double-Blind, Randomized, Crossover Comparative Study for Evaluating the Clinical Safety of Ephedrine Alkaloids-Free Ephedra Herb Extract (EFE).
Authors: Odaguchi H, Sekine M, Hyuga S, Hanawa T, Hoshi K, Sasaki Y, Aso M, Yang J, Hyuga M, Kobayashi Y, Hakamatsuka T, Goda Y, Kumagai Y Abstract Ephedra Herb is an important crude drug; it is used in various Traditional Japanese Medicine (Kampo) formulations. Its significant pharmacological effects have been believed to be attributed to ephedrine and pseudoephedrine, which sometimes induce adverse effects. On the other hand, it has been reported that some of these pharmacological effects are not dependent on ephedrine or pseudoephedrine. Ephedrine alkaloids-free Ephedra Herb extract has been newly developed. It ...
Source: Evidence-based Complementary and Alternative Medicine - September 5, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Chemical Differentiation of Genetically Identified Atractylodes japonica, A. macrocephala, and A. chinensis Rhizomes Using High-Performance Liquid Chromatography with Chemometric Analysis.
Authors: Kim JH, Doh EJ, Lee G Abstract The rhizome of Atractylodes japonica, which is a herbal medicine used for gastrointestinal therapeutics, has been categorized with A. macrocephala rhizome or A. chinensis rhizome based on different therapeutic criteria in Korea, China, and Japan. In the present study, 61 A. japonica, A. macrocephala, and A. chinensis rhizomes were collected from Korea and China and were genetically identified by internal transcribed spacer sequencing analysis. Chromatographic profiles were obtained from high-performance liquid chromatography analysis of the methanol and hot-water extracts of ...
Source: Evidence-based Complementary and Alternative Medicine - September 5, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

The Chinese Medicine, Jiedu Recipe, Inhibits the Epithelial Mesenchymal Transition of Hepatocellular Carcinoma via the Regulation of Smad2/3 Dependent and Independent Pathways.
In conclusion, JR inhibits liver cancer cells migration and invasion through epithelial mesenchymal transition (EMT) inhibition via Smad2/3 dependent and independent pathways, suggesting it is an effective therapeutic strategy against HCC metastasis. PMID: 30174709 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - September 5, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Safety Assessment of the Auto Manipulation Device for Acupuncture in Sprague-Dawley Rats: Preclinical Evaluation of the Prototype.
Conclusion: Our study suggested that the safety issue of AMDA operation in rats is feasible because there was no difference between control group and AMDA groups among real-time physiological functions and laboratory data. However, manipulation with higher frequency should be more preserved. PMID: 30174710 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - September 5, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Effectiveness and Safety of Acupotomy for Lumbar Disc Herniation: A Randomized, Assessor-Blinded, Controlled Pilot Study.
Conclusion: This study suggests greater therapeutic effects of acupotomy on relieving pain and improving the functional disability associated with LDH than those observed with manual acupuncture. PMID: 30174711 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - September 5, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

The Effect of Volatile Oil from Vernonia anthelmintica Seeds on Melanin Synthesis in B16 Cells and Its Chemical Analysis by GC-QTOF-MS.
Authors: Aobuli A, Maitusong J, Bakri M, Lu X, Maiwulanjiang M, Aisa HA Abstract Vernonia anthelmintica Willd. seeds have been used in folk medicine for the treatment of leukoderma in Xinjiang, China, for more than 300 years. The promoting activities of its volatile oil (AVO) in melanogenesis and its chemical composition were investigated in this paper. The bioactivities of AVO were examined by melanin synthesis and tyrosinase activity assay in B16 cells. Using GC-QTOF-MS technology, each compound of AVO contains a single separated peak in GC and the retention indices of every GC peak were calculated by the retenti...
Source: Evidence-based Complementary and Alternative Medicine - September 5, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Research on Roles of Mongolian Medical Warm Acupuncture in Inhibiting p38 MAPK Activation and Apoptosis of Nucleus Pulposus Cells.
Conclusion: Mongolian medical warm acupuncture may inhibit apoptosis of nucleus pulposus cells and activation of the extracellular matrix decomposition metabolism pathway and promote its anabolism. This process may rely on the oxidative stress matrix of the p38 MAPK pathway. PMID: 30174713 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - September 5, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Comparison between In Vitro Antiviral Effect of Mexican Propolis and Three Commercial Flavonoids against Canine Distemper Virus.
Authors: González-Búrquez MJ, González-Díaz FR, García-Tovar CG, Carrillo-Miranda L, Soto-Zárate CI, Canales-Martínez MM, Penieres-Carrillo JG, Crúz-Sánchez TA, Fonseca-Coronado S Abstract Propolis is a resin that honey bees (Apis mellifera) produce by mixing wax, exudates collected from tree shoots, pollen, and enzymes. It has been used for its biological properties against pathogenic microorganisms including those of viral origin. In the present study, we demonstrate the antiviral effect of Mexican propolis, as well as of the three commercial flavonoi...
Source: Evidence-based Complementary and Alternative Medicine - September 5, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

The Development and Application Evaluation of Meridian Energy Detection System in Traditional Oriental Medicine: A Preliminary Study.
In this study, our main objective was to evaluate the clinical application of the low voltage Meridian Energy Detection System in assessing the electrodermal activity (EDA) of the specific acupoints in a specific age group of healthy individuals and to assess the difference in the energy overview between the genders and specific time of assessment. 43 young healthy adults were recruited in a single group, nonrandomized, evaluation study. Written informed consent of each participant was obtained prior to the assessments. Results on energy overview between genders and specific time of assessment as well as factors influencin...
Source: Evidence-based Complementary and Alternative Medicine - September 5, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Aqueous Extract of Glucoraphanin-Rich Broccoli Sprouts Inhibits Formation of Advanced Glycation End Products and Attenuates Inflammatory Reactions in Endothelial Cells.
Authors: Sotokawauchi A, Ishibashi Y, Matsui T, Yamagishi SI Abstract We have previously shown that sulforaphane not only inhibits formation of advanced glycation end products (AGEs) but also exerts anti-inflammatory effects on AGE-exposed human umbilical vein endothelial cells (HUVECs) and AGE-injected rat aortae. Here we examined the effects of aqueous extract of glucoraphanin-rich broccoli sprouts on formation of AGEs and then investigated whether the extract could attenuate inflammatory or oxidative stress reactions in tumor necrosis factor-alpha (TNF-α)- or AGE-exposed HUVECs. Fresh broccoli sprouts were...
Source: Evidence-based Complementary and Alternative Medicine - September 5, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Cabbage (Brassica oleracea var. capitata) Protects against H2O2-Induced Oxidative Stress by Preventing Mitochondrial Dysfunction in H9c2 Cardiomyoblasts.
Authors: Yang DK Abstract Oxidative stress plays an important role in the progression of cardiac diseases, including ischemia/reperfusion injury, myocardial infarction, and heart failure. Growing evidence indicates that cabbage has various pharmacological properties against a wide range of diseases, such as cardiovascular diseases, hepatic diseases, and cancer. However, little is known about its effects on oxidative stress in cardiomyocytes or the underlying mechanisms. Therefore, the present study examined the effects of cabbage extract on oxidative stress in H9c2 cardiomyoblasts. Cell viability, reactive oxygen s...
Source: Evidence-based Complementary and Alternative Medicine - September 1, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Xingnaojing Injection Protects against Cerebral Ischemia Reperfusion Injury via PI3K/Akt-Mediated eNOS Phosphorylation.
Authors: Zhang YM, Qu XY, Zhai JH, Tao LN, Gao H, Song YQ, Zhang SX Abstract Xingnaojing (XNJ) injection, derived from traditional Chinese medicine formulation, has a protective effect against stroke, but the underlying mechanism is unclear, which severely limited its clinical application. This research aims to elucidate the role and mechanism of XNJ in reducing cerebral ischemic reperfusion (I/R) injury. Rats received 2 h cerebral ischemia followed by reperfusion of 24 h and were intraperitoneally given 5, 10, or 15 ml/kg XNJ 24 h before ischemia and at the onset of reperfusion, respect...
Source: Evidence-based Complementary and Alternative Medicine - September 1, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research