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The Versatile Effects of Dihydromyricetin in Health.
Authors: Li H, Li Q, Liu Z, Yang K, Chen Z, Cheng Q, Wu L Abstract Dihydromyricetin is a flavonoid isolated from Ampelopsis grossedentata, which is traditionally used in China. Dihydromyricetin exhibits health-benefiting activities with minimum adverse effects. Dihydromyricetin has been demonstrated to show antioxidative, anti-inflammatory, anticancer, antimicrobial, cell death-mediating, and lipid and glucose metabolism-regulatory activities. Dihydromyricetin may scavenge ROS to protect against oxidative stress or potentiate ROS generation to counteract cancer cells selectively without any effects on normal cells....
Source: Evidence-based Complementary and Alternative Medicine - September 28, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Antiobesity Activities of Methanolic Extracts of Amaranthus dubius, Cucurbita pepo, and Vigna unguiculata in Progesterone-Induced Obese Mice.
Authors: Nderitu KW, Mwenda NS, Macharia NJ, Barasa SS, Ngugi MP Abstract Amaranthus dubius, Vigna unguiculata, and Cucurbita pepo are traditionally used to manage obesity in Kenya but lack scientific validation to support their use. The aim of this study was to determine the antiobesity activity of methanolic leaf extracts of these plants in progesterone-induced obese mice. The activity of the methanolic leaf extracts was orally bioscreened in progesterone-induced obese mice at 200 mg/kg/bw and 400 mg/kg/bw. Body mass index was calculated once per week for four weeks and blood samples were obtained a...
Source: Evidence-based Complementary and Alternative Medicine - September 28, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Soybean Milk Inhibits Absorption and Intestinal Transmembrane Transport of Gegen in Rats.
Authors: Ling X, Xiang Y, Tang Q, Jin Z, Chen F, Tan X Abstract Puerariae Lobatae Radix, known as Gegen in Chinese, is widely used to treat cardiovascular diseases, diabetes, and many other chronic illnesses. Flavonoids are the main active components in Gegen and are found in high concentrations in soybeans. Few studies, however, have focused on the effects of flavonoid-rich food on the absorption of Gegen. Here, we report an in vivo pharmacokinetic study on rats to explore the effects of soybean milk on the absorption of Gegen and an in vitro Ussing chamber study of puerarin intestinal transmembrane absorption. Ar...
Source: Evidence-based Complementary and Alternative Medicine - September 28, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

A New Technique Using Low Volumes: A New Technique to Assess the Molluscicidal Activity Using Low Volumes.
Authors: Santos JAA, Cavalcante VP, Rangel LDS, Leite JCVA, Faria RX Abstract Schistosomiasis is a disease endemic in several states of Brazil. The population control of the transmitter mollusks is done with Bayluscide WP 70®, in the control programs. OMS preconize molluscicidal assays using Becker with 500 mL of final volume, restringing the number of natural products and synthetic drugs to be tested in function of high quantity of material necessary. A new technique to assess the toxic effects for Biomphalaria sp. is the purpose of this work, for developing adaptation for this aquatic organism, using a...
Source: Evidence-based Complementary and Alternative Medicine - September 28, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Antiamylase, Anticholinesterases, Antiglycation, and Glycation Reversing Potential of Bark and Leaf of Ceylon Cinnamon (Cinnamomum zeylanicum Blume) In Vitro.
Authors: Arachchige SPG, Abeysekera WPKM, Ratnasooriya WD Abstract Ethanol (95%) and dichloromethane : methanol (DCM : M, 1 : 1 v/v) bark extracts (BEs) and leaf extracts (LEs) of authenticated Ceylon cinnamon (CC) were studied for antiamylase, antiglucosidase, anticholinesterases, and antiglycation and glycation reversing potential in bovine serum albumin- (BSA-) glucose and BSA-methylglyoxal models in vitro. Further, total proanthocyanidins (TP) were quantified. Results showed significant differences (p
Source: Evidence-based Complementary and Alternative Medicine - September 28, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Evaluation of Antiulcer and Cytotoxic Potential of the Leaf, Flower, and Fruit Extracts of Calotropis procera and Isolation of a New Lignan Glycoside.
Authors: Al-Taweel AM, Perveen S, Fawzy GA, Rehman AU, Khan A, Mehmood R, Fadda LM Abstract Calotropis procera is traditionally used for treating many diseases including ulcers and tumors. It was thus deemed of interest to investigate and compare the antiulcer and cytotoxic activities of C. procera leaf, flower, and fruit extracts in an attempt to verify its traditional uses. Phytochemical studies on the fruits, flowers, and leaves of C. procera, collected from the desert of Saudi Arabia, led to the isolation of one new lignan 7'-methoxy-3'-O-demethyl-tanegool-9-O-β-d-glucopyranoside and five known compounds f...
Source: Evidence-based Complementary and Alternative Medicine - September 28, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

The Effect of Schinus terebinthifolius Raddi (Anacardiaceae) Bark Extract on Histamine-Induced Paw Edema and Ileum Smooth Muscle Contraction.
Authors: Nunes-Neto PA, Peixoto-Sobrinho TJDS, da Silva Júnior ED, Leopoldina da Silva J, Rodrigo da Silva Oliveira A, Pupo AS, Araújo AV, da Costa-Silva JH, Wanderley AG Abstract Schinus terebinthifolius Raddi (Anacardiaceae), popularly known as red aroeira, is used in traditional medicine to treat inflammatory, gastric, and respiratory disorders. The aim of this study was to evaluate the antihistaminic activity of S. terebinthifolius (St) bark extract by using in vivo and in vitro experimental models. The effects of St were investigated on contractions induced by histamine, carbachol, and potassium ...
Source: Evidence-based Complementary and Alternative Medicine - September 22, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Da-Cheng-Qi Decoction Combined with Conventional Treatment for Treating Postsurgical Gastrointestinal Dysfunction.
CONCLUSION: DCQD could improve PGD symptoms and promotion clinical effectiveness. PMID: 28928788 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - September 22, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

The Long-Term Course of Outcomes for Lumbar Intervertebral Disc Herniation following Integrated Complementary and Alternative Medicine Inpatient Treatment: A Prospective Observational Study.
Authors: Kim MH, Lee YJ, Shin JS, Lee J, Jeong H, Kim MR, Park SM, Go U, Kim SM, Kim JY, Hwang DG, Ha IH Abstract A prospective observational study was conducted in 524 lumbar intervertebral disc herniation (LDH) inpatients to report the long-term effects of complementary and alternative medicine (CAM) treatment. Participants received integrative CAM treatment during hospitalization, from June 2012 to May 2013, and long-term outcomes were assessed from July to August 2016. Numerical rating scales (NRSs) of back and leg pain, the Oswestry disability index (ODI), satisfaction, surgery, recurrence, and current care st...
Source: Evidence-based Complementary and Alternative Medicine - September 22, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Skin Wound Healing Potential and Mechanisms of the Hydroalcoholic Extract of Leaves and Oleoresin of Copaifera langsdorffii Desf. Kuntze in Rats.
Authors: Gushiken LFS, Hussni CA, Bastos JK, Rozza AL, Beserra FP, Vieira AJ, Padovani CR, Lemos M, Polizello Junior M, da Silva JJM, Nóbrega RH, Martinez ERM, Pellizzon CH Abstract The wound healing is a complex process which, sometimes, can be a problem in public health because of the possibility of physical disability or even death. Due to the lack of a gold standard drug in skin wound treatment and aiming at the discovery of new treatments in skin repair and the mechanisms involved in the process, we used oleoresin (OR) from Copaifera langsdorffii and hydroalcoholic extract of the leaves (EH) to treat ra...
Source: Evidence-based Complementary and Alternative Medicine - September 22, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Wu-Mei-Wan Reduces Insulin Resistance via Inhibition of NLRP3 Inflammasome Activation in HepG2 Cells.
In this study, we aimed to explore the effects and mechanisms of WMW on insulin resistance in HepG2 cells. HepG2 cells were pretreated with palmitate (0.25 mM) to impair the insulin signaling pathway. Then, they were treated with different doses of WMW-containing medicated serum and stimulated with 100 nM insulin. Results showed that palmitate could reduce the glucose consumption rate in HepG2 cells and impair insulin signaling related to phosphorylation of insulin receptor (IR) and insulin receptor substrate-1 (IRS-1), thereby regulating the downstream signaling pathways. However, medicated serum of WMW rest...
Source: Evidence-based Complementary and Alternative Medicine - September 22, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Garidisan: Improving the Quality of Ulcer Healing in Rats with Ulcerative Colitis.
In conclusion, Garidisan promoted tissue maturation of regenerated tissues by regulating the immune balance and improved functional maturity of regenerated tissues by reducing collagen formation, promoting maturation of new blood vessels, and increasing expression of growth factors and their receptors. PMID: 28928792 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - September 22, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

A Metabolomics-Based Strategy for the Mechanism Exploration of Traditional Chinese Medicine: Descurainia sophia Seeds Extract and Fractions as a Case Study.
In conclusion, the metabolomics method, combined with split fractions of extract, is a powerful approach for illustrating pathologic changes of Chinese medicine syndrome and action mechanisms of traditional Chinese medicine. PMID: 28932251 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - September 22, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Transient Expression of Lumbrokinase (PI239) in Tobacco (Nicotiana tabacum) Using a Geminivirus-Based Single Replicon System Dissolves Fibrin and Blood Clots.
Authors: Dickey A, Wang N, Cooper E, Tull L, Breedlove D, Mason H, Liu D, Wang KY Abstract Lumbrokinases, a group of fibrinolytic enzymes extracted from earthworm, have been widely used to prevent and treat various cardiovascular diseases. They specifically target fibrin to effectively degrade thrombi without major side effects. Plant expression systems are becoming potential alternative expression platforms for producing pharmaceutical proteins. In this work, a lumbrokinase (PI239) was produced from a plant system. Both wild-type (WT) and plant codon-optimized (OP) PI239 gene sequences were synthesized and cloned ...
Source: Evidence-based Complementary and Alternative Medicine - September 22, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Yinchen Linggui Zhugan Decoction Ameliorates Nonalcoholic Fatty Liver Disease in Rats by Regulating the Nrf2/ARE Signaling Pathway.
Authors: Guo Y, Li JX, Wang YL, Mao TY, Chen C, Xie TH, Han YF, Tan X, Han HX Abstract Yinchen Linggui Zhugan Decoction (YCLGZGD) is the combination of Linggui Zhugan (LGZGD) and Yinchenhao (YCHD) decoctions, two famous traditional Chinese medicine prescriptions. In previous studies, we found that Yinchen Linggui Zhugan Decoction (YCLGZGD) could regulate lipid metabolism disorder and attenuate inflammation in pathological process of nonalcoholic fatty liver disease (NAFLD). However, the exact underlying mechanism remains unknown. The aim of this study was to explore the effect of Yinchen Linggui Zhugan Decoction on...
Source: Evidence-based Complementary and Alternative Medicine - September 22, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Prevalence and Correlates of Complementary and Alternative Medicine Use among Patients with Lung Cancer: A Cross-Sectional Study in Beirut, Lebanon.
This study aimed to assess CAM use among lung cancer patients in Lebanon. Using a cross-sectional design, 150 lung cancer patients attending the Basile Cancer Institute at the American University of Beirut Medical Center were interviewed. Participants completed a questionnaire addressing sociodemographic characteristics, lung cancer condition, and use of CAM. The main outcome of interest was "use of any CAM therapy since diagnosis." Prevalence of CAM use was 41%. The most commonly used CAM modality among study participants was "dietary supplements/special foods." Results of the multiple logistic regress...
Source: Evidence-based Complementary and Alternative Medicine - September 17, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Effects of Angelica dahurica and Rheum officinale Extracts on Excisional Wound Healing in Rats.
In this study, AE and RE were applied in wound treatment to investigate their healing effects. Thirty Sprague-Dawley rats with dorsal full-thickness skin excision were divided into normal saline (NS), AE, RE, AE plus RE (ARE), and Biomycin (BM) groups. The treatment and area measurement of wounds were applied daily for 21 days. Wound biopsies and blood samples were obtained for histology examinations and cytokine analysis. Results showed that wound contraction in ARE group was significantly higher than that in NS and BM groups (P 0.05), and plasma TGF-β1 levels were significantly lower than those in the NS group on days 3-4 (P
Source: Evidence-based Complementary and Alternative Medicine - September 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Protective Effects of Bogijetong Decoction and Its Selected Formula on Neuropathic Insults in Streptozotocin-Induced Diabetic Animals.
Authors: Kim KJ, Namgung U, Cho CS Abstract Bogijetong decoction (BGJTD) is a mixture of herbal formulation which is used in the traditional Korean medicine for the treatment of neuropathic pain caused by diabetes. Here, we investigated the regulatory effects of BGJTD and its reconstituted decoction subgroups on the neuropathic responses in streptozotocin- (STZ-) induced diabetic animals. Be decoction (BeD) was formulated by selecting individual herbal components that induced neurite outgrowth most efficiently in each subgroup. BeD induced the neurite outgrowth in DRG neurons most efficiently among decoction subgro...
Source: Evidence-based Complementary and Alternative Medicine - September 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Manual Acupuncture at PC6 Ameliorates Acute Restraint Stress-Induced Anxiety in Rats by Normalizing Amygdaloid Noradrenergic Response.
Authors: Zhao Z, Kim SC, Liu H, Zhang J, Wang Y, Cho IJ, Lee BH, Song CH, Lee CW, Yang CH, Zhao R, Wu Y Abstract Acupuncture improves ethanol withdrawal-induced anxiety in rats in an acupoint-dependent manner. Thus, the present study investigated the effects of acupuncture on acute restraint stress- (ARS-) induced anxiety. Male rats were exposed to ARS for 3 h followed by acupuncture at either PC6 (Neiguan), HT7 (Shenmen), or a nonacupoint (tail) once a day for three consecutive days. Five minutes after the third acupuncture treatment, anxiety-like behavior was evaluated in an elevated plus maze (EPM). Addit...
Source: Evidence-based Complementary and Alternative Medicine - September 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Effects of Wannachawee Recipe with Antipsoriatic Activity on Suppressing Inflammatory Cytokine Production in HaCaT Human Keratinocytes.
This study defined mechanisms for its antiproliferation and anti-inflammatory effects in HaCaT cells. The cytotoxicity and antiproliferation results from SRB and CCK-8 assays showed that WCR inhibited the growth and viability of HaCaT cells in a concentration-dependent manner. The distribution of cell cycle phases determined by flow cytometry showed that WCR did not interrupt cell cycle progression. Interestingly, RT-qPCR revealed that WCR significantly decreased the mRNA expression of IL-1β, IL-6, IL-8, IL-17A, IL-22, IL-23, and TNF-α but induced IL-10 expression in TNF-α- and IFN-γ-induced HaCaT ce...
Source: Evidence-based Complementary and Alternative Medicine - September 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Comparison of the Therapeutic Effects of Acupuncture at PC6 and ST36 for Chronic Myocardial Ischemia.
Authors: Shi L, Fang J, Zhao J, Liu G, Zhao Q, Zhang J, Zhang J, Zhu B, Liang F, Rong P Abstract We aimed to compare the differences of the effects on chronic myocardial ischemia (MI) of acupuncture at PC6 and ST36. The chronic MI model of minipigs was created by implanting an Ameroid constrictor on the left anterior descending coronary artery (LAD) and then two weeks' acupuncture was stimulated at PC6 or ST36, respectively. The results showed that both acupoints' stimulation decreased the serous cardiac troponin T (cTnT) and ischemia modified albumin (IMA) significantly and improved the ischemic ECG changes. The a...
Source: Evidence-based Complementary and Alternative Medicine - September 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Researches on Transcriptome Sequencing in the Study of Traditional Chinese Medicine.
Authors: Xin J, Zhang RC, Wang L, Zhang YQ Abstract Due to its incomparable advantages, the application of transcriptome sequencing in the study of traditional Chinese medicine attracts more and more attention of researchers, which greatly promote the development of traditional Chinese medicine. In this paper, the applications of transcriptome sequencing in traditional Chinese medicine were summarized by reviewing recent related papers. PMID: 28900463 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - September 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Synergistic Antioxidant and Anti-Inflammatory Effects between Modified Citrus Pectin and Honokiol.
Authors: Ramachandran C, Wilk B, Melnick SJ, Eliaz I Abstract Inflammation is a normal physiological process; however, dysregulation of this process may contribute to inflammatory-based chronic disorders and diseases in animals and humans. Therefore, the antioxidant and anti-inflammatory properties of natural products, often recognized in traditional medicine systems, represent therapeutic modalities to reduce or prevent uncontrolled inflammatory processes which in turn potentially ameliorate or prevent sequelae of inflammatory-based symptoms of chronic diseases. We have investigated the antioxidant and anti-inflam...
Source: Evidence-based Complementary and Alternative Medicine - September 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Maoto, a Traditional Japanese Herbal Medicine, Inhibits Uncoating of Influenza Virus.
In this study, a culturing system for influenza was used to test the effect of maoto. A549 cells in the culture were infected with influenza virus A (PR8) and followed after treatment with maoto; the virus titers in the culture supernatant, intracellular viral proteins, and viral RNA were determined. When infected cells were cultured with maoto for 24 hr, the virus titer and protein were significantly reduced compared with medium only. Other subtypes, A/H3N2, H1N1pdm, and B, were also inhibited by maoto. Proliferation of viral RNA in a 6 hr culture was inhibited by maoto in the early phase, especially in the ...
Source: Evidence-based Complementary and Alternative Medicine - September 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Suppressive Effect of the n-Hexane Extract of Litsea japonica Fruit Flesh on Monosodium-Iodoacetate-Induced Osteoarthritis in Rats.
We examined the antiosteoarthritic effect of the n-hexane extract of Litsea japonica fruit flesh (LJF-HE) in a rat model of monosodium-iodoacetate- (MIA-) induced osteoarthritis. LJF-HE significantly reduced the difference in weight-bearing capabilities of the hind paws between healthy and MIA-treated rats. Histological examination of the knee joints indicated that LJF-HE suppressed cartilage and bone destruction. Additionally, there were decreases in the expression of matrix metalloproteinase-2 and metalloproteinase-9 and cyclooxygenase-2 in the joints. The serum levels of deoxypyridinoline (DPD) and osteocalcin, which ar...
Source: Evidence-based Complementary and Alternative Medicine - September 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Antioxidant and Anti-Inflammatory Properties of Anacardium occidentale Leaf Extract.
Authors: Souza NC, de Oliveira JM, Morrone MDS, Albanus RD, Amarante MDSM, Camillo CDS, Langassner SMZ, Gelain DP, Moreira JCF, Dalmolin RJS, Pasquali MAB Abstract In tropical America, principally in Northeastern Brazil, the leaf extract of Anacardium occidentale is traditionally used for treatment of different diseases. However, chemical and biological properties and activities of Anacardium occidentale are poorly investigated and known. Here, we evaluated the antioxidant and anti-inflammatory activities "in vitro" of leaf extract from Anacardium occidentale. Our results show that leaf extract exhibits a...
Source: Evidence-based Complementary and Alternative Medicine - September 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Manual Acupuncture Suppresses the Expression of Proinflammatory Proteins Associated with the NLRP3 Inflammasome in the Hippocampus of SAMP8 Mice.
Authors: Ding N, Jiang J, Lu M, Hu J, Xu Y, Liu X, Li Z Abstract OBJECTIVE: To investigate the effect of manual acupuncture (MA) on NLRP3 inflammasome-related proteins. METHODS: SAMP8 mice were randomly divided into Alzheimer's disease (AD) group, the MA group, and the medicine (M) group. Mice in the M group were treated with donepezil hydrochloride at 0.65 μg/g. In the MA group, MA was applied on Baihui (GV20) and Yintang (GV29) for 20 min and then pricked at Shuigou (GV26). The Morris water maze was applied to assess spatial learning and memory. Immunohistochemical staining and western blot a...
Source: Evidence-based Complementary and Alternative Medicine - September 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Plants-Derived Neuroprotective Agents: Cutting the Cycle of Cell Death through Multiple Mechanisms.
Authors: Elufioye TO, Berida TI, Habtemariam S Abstract Neuroprotection is the preservation of the structure and function of neurons from insults arising from cellular injuries induced by a variety of agents or neurodegenerative diseases (NDs). The various NDs including Alzheimer's, Parkinson's, and Huntington's diseases as well as amyotropic lateral sclerosis affect millions of people around the world with the main risk factor being advancing age. Each of these diseases affects specific neurons and/or regions in the brain and involves characteristic pathological and molecular features. Hence, several in vitro and ...
Source: Evidence-based Complementary and Alternative Medicine - September 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Acyclic Sesquiterpenes from the Fruit Pericarp of Sapindus saponaria Induce Ultrastructural Alterations and Cell Death in Leishmania amazonensis.
Authors: Moreira AL, Scariot DB, Pelegrini BL, Pessini GL, Ueda-Nakamura T, Nakamura CV, Ferreira ICP Abstract Previous studies reported antiprotozoal activities of Sapindus saponaria L. The aim of this work was the evaluation of antileishmanial activity and mechanism of action of extract and fractions of S. saponaria L. Hydroethanolic extract (EHA) obtained from fruit pericarps was fractionated using solid-phase extraction in a reversed phase, resulting in fractions enriched with saponins (SAP fraction) and acyclic sesquiterpene oligoglycosides (OGSA fraction). The activities of EHA, SAP, and OGSA were evaluated b...
Source: Evidence-based Complementary and Alternative Medicine - September 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Medicinal Plants for the Treatment of Local Tissue Damage Induced by Snake Venoms: An Overview from Traditional Use to Pharmacological Evidence.
Authors: Félix-Silva J, Silva-Junior AA, Zucolotto SM, Fernandes-Pedrosa MF Abstract Snakebites are a serious problem in public health due to their high morbimortality. Most of snake venoms produce intense local tissue damage, which could lead to temporary or permanent disability in victims. The available specific treatment is the antivenom serum therapy, whose effectiveness is reduced against these effects. Thus, the search for complementary alternatives for snakebite treatment is relevant. There are several reports of the popular use of medicinal plants against snakebites worldwide. In recent years, many s...
Source: Evidence-based Complementary and Alternative Medicine - September 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Ginger Ingredients Alleviate Diabetic Prostatic Complications: Effect on Oxidative Stress and Fibrosis.
This study investigated the effect of different ginger ingredients: zingerone, geraniol, and 6-gingerol on the prostate in diabetic rats. Diabetes was induced in Wistar rats by streptozotocin intraperitoneal injection (50 mg/kg), and the rats were left for 10 weeks to develop prostatic complications. In diabetic treated groups, rats received daily oral zingerone, geraniol, and 6-gingerol in doses of 20, 200, and 75 mg/kg, respectively, in the last 8 weeks. Treatment with the compounds caused changes in the ventral prostate of diabetic animals as indicated by the columnar ductal epithelium and dense secretions...
Source: Evidence-based Complementary and Alternative Medicine - September 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Herbal Medicines: Personal Use, Knowledge, Attitude, Dispensing Practice, and the Barriers among Community Pharmacists in Gondar, Northwest Ethiopia.
CONCLUSION: Although community pharmacists in Gondar, Northwest Ethiopia, commonly use and demonstrated good attitude towards herbal medicines, they are less involved in dispensing such products. They are also challenged with limited knowledge on and access to herbal medicine information. Thus, pharmacy educators, professional organizations, and the government shall pay more attention to solve the problem. Regulatory provisions on herbal medicine dispensing must be enacted and communicated very well. PMID: 28904558 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - September 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Cartilage Protection and Analgesic Activity of a Botanical Composition Comprised of Morus alba, Scutellaria baicalensis, and Acacia catechu.
Authors: Yimam M, Horm T, Wright L, Jiao P, Hong M, Brownell L, Jia Q Abstract Although there have been augmented advances in drug discovery, current OA management is inadequate due to the lack of successful therapies proven to be effective in modifying disease progression. For some, the risk outweighs the benefit. As a result, there is a desperate need for safe and efficacious natural alternatives. Here we evaluated a composition from Morus alba, Scutellaria baicalensis, and Acacia catechu in maintaining joint structural integrity and alleviating OA associated symptoms in monoiodoacetate- (MIA-) induced rat OA dis...
Source: Evidence-based Complementary and Alternative Medicine - September 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Antidiabetic Effect of Tibetan Medicine Tang-Kang-Fu-San on High-Fat Diet and Streptozotocin-Induced Type 2 Diabetic Rats.
Authors: Duan B, Zhao Z, Lin L, Jin J, Zhang L, Xiong H, Ta N, Gao T, Mei Z Abstract The aim of this study was to investigate the antidiabetic effects of a Tibetan medicine, Tang-Kang-Fu-San (TKFS), on experimental type 2 diabetes mellitus (T2DM) rats and to explore its underlying mechanisms. Firstly two major chemical compositions of TKFS, gallic acid and curcumin, were characterized by HPLC fingerprint analysis. Next T2DM in rats was induced by high-fat diet and a low-dose streptozotocin (STZ 35 mg/kg). Then oral gavage administration of three different doses of TKFS (0.3 g/kg, 0.6 g/kg, and ...
Source: Evidence-based Complementary and Alternative Medicine - September 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Understanding Mind-Body Interaction from the Perspective of East Asian Medicine.
CONCLUSION: The present findings will further the current understanding of the relationship between the mind and body from the perspective of East Asian medicine. Western medicine characterizes emotional disorders using "neural" language while East Asian medicine uses "somatic" language. PMID: 28904561 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - September 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Trends in Medicinal Uses of Edible Wild Vertebrates in Brazil.
Authors: Alves RRN, Oliveira TPR, Medeiros MFT Abstract The use of food medicines is a widespread practice worldwide. In Brazil, such use is often associated with wild animals, mostly focusing on vertebrate species. Here we assessed taxonomic and ecological trends in traditional uses of wild edible vertebrates in the country, through an extensive ethnobiological database analysis. Our results showed that at least 165 health conditions are reportedly treated by edible vertebrate species (n = 204), mostly fishes and mammals. However, reptiles stand out presenting a higher plasticity in the treatment of multiple healt...
Source: Evidence-based Complementary and Alternative Medicine - September 14, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Practice of Comparative Effectiveness Research to Identify Treatment Characteristics of Similar Chinese Patent Medicine for Angina Pectoris.
Authors: Cao H, Wang P, Li N, Liu D, Ma J, Fan R, Zhou Z Abstract OBJECTIVE: Individualized application of TCM is not easy and may lead to undesirable results, such as poor effect or even adverse reactions. This trial aims to compare two common Chinese patent medicines with similar effects. BACKGROUND OF THE RESEARCH: Four hospitals carried out the test at the same time in Tianjin city of China. PARTICIPANTS: 144 patients were involved in this study; all patients must meet the diagnostic criteria. INTERVENTIONS: Qishen Yiqi pills, compound danshen pills, and their placebos; an efficacy analysis was cond...
Source: Evidence-based Complementary and Alternative Medicine - September 14, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Effective Heart Disease Detection Based on Quantitative Computerized Traditional Chinese Medicine Using Representation Based Classifiers.
Authors: Shu T, Zhang B, Tang YY Abstract At present, heart disease is the number one cause of death worldwide. Traditionally, heart disease is commonly detected using blood tests, electrocardiogram, cardiac computerized tomography scan, cardiac magnetic resonance imaging, and so on. However, these traditional diagnostic methods are time consuming and/or invasive. In this paper, we propose an effective noninvasive computerized method based on facial images to quantitatively detect heart disease. Specifically, facial key block color features are extracted from facial images and analyzed using the Probabilistic Colla...
Source: Evidence-based Complementary and Alternative Medicine - September 14, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Effects of Combined Far-Infrared Radiation and Acupuncture at ST36 on Peripheral Blood Perfusion and Autonomic Activities.
Authors: Yang CC, Lin GM, Wang JH, Chu HC, Wu HT, Chen JJ, Sun CK Abstract Using four-channel photoplethysmography (PPG) for acquiring peripheral arterial waveforms, this study investigated vascular and autonomic impacts of combined acupuncture-far infrared radiation (FIR) in improving peripheral circulation. Twenty healthy young adults aged 25.5 ± 4.6 were enrolled for 30-minute measurement. Each subject underwent four treatment strategies, including acupuncture at ST36 (Zusanli), pseudoacupuncture, FIR, and combined acupuncture-FIR at different time points. Response was assessed at 5-minute intervals. Area...
Source: Evidence-based Complementary and Alternative Medicine - September 9, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Atractylodin Induces Myosin Light Chain Phosphorylation and Promotes Gastric Emptying through Ghrelin Receptor.
Authors: Bai Y, Zhao YH, Xu JY, Yu XZ, Hu YX, Zhao ZQ Abstract Atractylodin is one of the main constituents in the rhizomes of Atractylodes lancea Thunb., being capable of treating cancer cachexia-anorexia and age-related diseases as an agonist of growth hormone secretagogue receptor (GHSR). GHSR was herein expressed in human gastric smooth muscle cells (HGSMCs) and activated by ghrelin receptor agonist L-692,585. Like L-692,585, atractylodin also increased Ca(2+) and enhanced the phosphorylation of myosin light chain (MLC) through GHSR in HGSMCs. In addition, atractylodin promoted gastric emptying and MLC phosphor...
Source: Evidence-based Complementary and Alternative Medicine - September 9, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

iTRAQ-Based Quantitative Proteomics Analysis of the Protective Effect of Yinchenwuling Powder on Hyperlipidemic Rats.
This study enhanced our understanding on the therapeutic effects and mechanism of YCL on hyperlipidemia. PMID: 28883884 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - September 9, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Synergistic Antitumor Effects of Berbamine and Paclitaxel through ROS/Akt Pathway in Glioma Cells.
Authors: Jia F, Ruan S, Liu N, Fu L Abstract In our preliminary study, Berbamine (BA), one of the most commonly used traditional Chinese medicines, was effective in inducing the intracellular ROS levels. Since the regulation of cellular antioxidant capacity is crucial to the sensitivity of Ptx, it is feasible to propose that sensitizing cells to Ptx can be achieved through increasing the antioxidant capacity by codelivering BA. Cytotoxicity test demonstrates that either single or combinational treatment of BA and Ptx dose-dependently inhibits the proliferation of U-87 cells. Median-effect analysis clearly proves th...
Source: Evidence-based Complementary and Alternative Medicine - September 9, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Differences in Complexion between Cold- and Heat-Prescription Groups in Sasang Medicine.
This study quantitatively analyzed the complexion of patients, which is used as a diagnostic element in clinical practice. It is hoped that the results will contribute to objective medical treatments in the future, such as determining an appropriate herbal prescription based on the patient's complexion. PMID: 28883886 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - September 9, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Oral Chinese Herbal Medicine as an Adjuvant Treatment for Chemotherapy, or Radiotherapy, Induced Myelosuppression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
CONCLUSIONS: CHM as an adjuvant can alleviate myelosuppression induced by chemotherapy or radiotherapy, reduce grade III-IV toxicity, and maintain therapeutic dose and treatment cycle. However, due to heterogeneity and publication bias, the results should be interpreted with caution and validated by conducting strictly designed multicenter RCTs of high quality and large scale. PMID: 28855947 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - September 2, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Astragalus Granule Prevents Ca(2+) Current Remodeling in Heart Failure by the Downregulation of CaMKII.
CONCLUSION: AG treatment protected the failing heart against electrical remodeling and ICa-L remodeling by downregulating CaMKII. PMID: 28855948 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - September 2, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Platonia insignis Mart., a Brazilian Amazonian Plant: The Stem Barks Extract and Its Main Constituent Lupeol Exert Antileishmanial Effects Involving Macrophages Activation.
This study was aimed at evaluating the antileishmanial effects of the ethanol extract (EtOH-Ext), hexane fraction (Hex-F), and its main isolated Lupeol obtained from stem barks of P. insignis against Leishmania (Leishmania) amazonensis, as well as their cytotoxicity and possible mechanisms of action. The EtOH-Ext, Hex-F, and Lupeol inhibited the growth of L. amazonensis promastigote forms at IC50 of 174.24, 45.23, and 39.06 µg/mL, respectively, as well as L. amazonensis axenic amastigote forms at IC50 of 40.58, 35.87, and 44.10 µg/mL, respectively. The mean cytotoxic concentrations for macrophages...
Source: Evidence-based Complementary and Alternative Medicine - September 1, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Zanthoxylum heitzii Modulates Ferric Nitrilotriacetate-Dependent Oxidative Alterations in Four Vital Organs: An In Vitro Organoprotective Model.
This study investigated the ability of extracts from the leaves, fruits, roots, and barks of Z. Heitzii to inhibit Fe-NTA mediated oxidative damage in rats. The supernatant of rat liver homogenates was pretreated with the extracts for one hour before the induction of oxidative damage using a solution of Fe-NTA (400 mM). The activities of superoxide dismutase (SOD), catalase, and peroxidases were measured together with the marker of lipid peroxidation and the level of glutathione. The pretreated groups showed a significant increase in the activity of SOD, catalase, and peroxidases. The methanolic extract from the lea...
Source: Evidence-based Complementary and Alternative Medicine - September 1, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Systematic Review on Acupuncture for Treatment of Dysphagia after Stroke.
Authors: Ye Q, Xie Y, Shi J, Xu Z, Ou A, Xu N Abstract OBJECTIVE: To assess the therapeutic efficacy of acupuncture for dysphagia after stroke. METHODS: Seven electronic databases were searched from their inception until 31 September 2016. All randomized controlled trials (RCTs) incorporating acupuncture or acupuncture combined with other interventions for treatment of dysphagia after stroke were enrolled. Then they were extracted and assessed by two independent evaluators. Direct comparisons were conducted in RevMan 5.3.0 software. RESULTS: 6010 patients of 71 papers were included. The pooled analysis of e...
Source: Evidence-based Complementary and Alternative Medicine - September 1, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Complementary and Alternative Therapies for Functional Gastrointestinal Diseases 2016.
Authors: Chen JDZ, Yin J, Hou X, Takahashi T PMID: 28848614 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - August 30, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Clinical Effects of Laser Acupuncture plus Chinese Cupping on the Pain and Plasma Cortisol Levels in Patients with Chronic Nonspecific Lower Back Pain: A Randomized Controlled Trial.
CONCLUSION: Laser acupuncture plus Chinese cupping at the Weizhong (BL40) and Ashi acupoints effectively reduced pain and inflammation in chronic nonspecific LBP. This therapy could be a suitable option for LBP treatment in clinical settings. PMID: 28848615 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - August 30, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research