Pharmacologic Effect of Miao Medicine Illicium simonsii Maxim. on Collagen-Induced Arthritis in Rats.
Authors: Zhang QZ, Hu XY, Yao WQ, Wan XL, Liang ZC, Dang RM, Yang ZM, Xia YL Abstract Objectives: To study the pharmacologic effect and mechanism of action of Miao medicine Illicium simonsii Maxim. (ISM) in treating rheumatoid arthritis. Methods: Sixty rats were randomly divided to six groups: normal control (normal), collagen-induced arthritis (CIA) model (model), CIA + tripterygium glycosides (TG), CIA + ISM high dose oral (ISM-H), CIA + ISM low-dose oral (ISM-L), and CIA + ISM topical application (ISM-T). The treatment doses were selected based on published reports and folk medicine practice. The outcome mea...
Source: Evidence-based Complementary and Alternative Medicine - November 10, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

The Therapeutic Effect of the Chinese Herbal Medicine, Rehmanniae Radix Preparata, in Attention Deficit Hyperactivity Disorder via Reversal of Structural Abnormalities in the Cortex.
Authors: Yuan H, Yang M, Han X, Ni X Abstract Rehmanniae radix preparata is extracted from wine-steaming the Rehmannia root, a scrophulariaceae plant. It has been used for thousands of years with effects of nourishing kidney-yin, benefiting essence and filling marrow based on traditional Chinese medicine (TCM) theory. Rehmanniae radix preparata has antioxidant, antisenescence, anti-inflammatory, and neuroprotective properties. It is the most popular Traditional Chinese medicinal compound (TCMC) used in attention deficit hyperactivity disorder (ADHD) therapy. However, few studies have been conducted exploring the ef...
Source: Evidence-based Complementary and Alternative Medicine - November 10, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Plant-Derived Products for Treatment of Vascular Intima Hyperplasia Selectively Inhibit Vascular Smooth Muscle Cell Functions.
Authors: Xu K, Al-Ani MK, Pan X, Chi Q, Dong N, Qiu X Abstract Natural products are used widely for preventing intimal hyperplasia (IH), a common cardiovascular disease. Four different cells initiate and progress IH, namely, vascular smooth muscle, adventitial and endothelial cells, and circulation or bone marrow-derived cells. Vascular smooth muscle cells (VSMCs) play a critical role in initiation and development of intimal thickening and formation of neointimal hyperplasia. In this review, we describe the different originating cells involved in vascular IH and emphasize the effect of different natural products on...
Source: Evidence-based Complementary and Alternative Medicine - November 10, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Biological Activities of Four Adaptogenic Plant Extracts and Their Active Substances on a Rotifer Model.
Authors: Mácsai L, Datki ZL, Csupor D, Horváth A, Zomborszki ZP Abstract Rotifers have been widely used as well-characterized models of aging, since their multiorgan character makes them suitable as in vivo toxicological and lifespan models. Here we report the assessment of four adaptogenic plants and their extracts for the first time in this model. The effects on rotifer viability of extracts and characteristic active markers of Panax ginseng, Withania somnifera, Leuzea carthamoides, and Rhodiola rosea were tested in vivo. The crude extracts were nontoxic to Philodina acuticornis bdelloid rotifers; h...
Source: Evidence-based Complementary and Alternative Medicine - November 10, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

α-Mangostin Alleviated Lipopolysaccharide Induced Acute Lung Injury in Rats by Suppressing NAMPT/NAD Controlled Inflammatory Reactions.
This study was designed to investigate its therapeutic effects on acute lung injury (ALI) and explore the underlying mechanisms of action. Rats from treatment groups were subject to oral administration of MAN for 3 consecutive days beforehand, and then ALI was induced in all the rats except for normal controls via an intraperitoneal injection with lipopolysaccharide. The severity of disease was evaluated by histological examination and hematological analysis. Protein expressions in tissues and cells were examined with immunohistochemical and immunoblotting methods, respectively. The levels of cytokines and nicotinamide ade...
Source: Evidence-based Complementary and Alternative Medicine - November 10, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Randomized, Double-Blind, Placebo-Controlled Study of Modified Erzhi Granules in the Treatment of Menopause-Related Vulvovaginal Atrophy.
Conclusion: MEG significantly alleviates menopause-related vulvovaginal atrophy, with no overt adverse effects on the endometrium, breast, hepatic, and renal functions. PMID: 30405741 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - November 10, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Anti-Inflammatory Activity of Rg3-Enriched Korean Red Ginseng Extract in Murine Model of Sepsis.
Authors: Saba E, Jeong D, Irfan M, Lee YY, Park SJ, Park CK, Rhee MH Abstract Ginseng has therapeutic effects on various bodily disorders ranging from minor inflammation to major cardiovascular diseases. In our study, we explored the anti-inflammatory effects of Rg3-enriched red ginseng extract (Rg3-RGE), a ginsenoside belonging to the panaxadiol group. We employed nitric oxide assay (NO) and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR), western blot, and hematoxylin and eosin staining (H&E) to elucidate the anti...
Source: Evidence-based Complementary and Alternative Medicine - November 10, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Efficacy and Safety of Ginkgo Biloba Pills for Coronary Heart Disease with Impaired Glucose Regulation: Study Protocol for a Series of N-of-1 Randomized, Double-Blind, Placebo-Controlled Trials.
Discussion: Ginkgo biloba preparations are widely used in cardiovascular diseases both at home and abroad due to their definite curative effect, few side effects, various dosage forms, and convenient and safe use. Diabetes mellitus is a high-risk factor for the occurrence of cardiovascular disease. Therefore, it is of great significance to control the impaired glucose regulation and slow down the development of diabetes and reduce the incidence and mortality of cardiovascular diseases. This trial is registered with ClinicalTrials.gov (ID: NCT03483779). PMID: 30405743 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - November 10, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Safety of Acupuncture in Patients Taking Newer Oral Anticoagulants: A Retrospective Chart Review Study.
The objective of this study was to assess the safety of acupuncture in patients taking NOACs. The medical records in the Stroke Center at Kyung Hee University Korean Medicine Hospital were retrospectively reviewed to identify patients who had received acupuncture between January 2017 and September 2017. The patients were divided into groups according to whether they were taking an NOAC, an antiplatelet agent, or no anticoagulant therapy. Bleeding-related side effects that occurred immediately after removal of acupuncture needles were recorded. Three hundred and sixteen patients underwent 10,177 acupuncture sessions during ...
Source: Evidence-based Complementary and Alternative Medicine - November 10, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Total Flavone of Rhododendron Improves Cerebral Ischemia Injury by Activating Vascular TRPV4 to Induce Endothelium-Derived Hyperpolarizing Factor-Mediated Responses.
Conclusions: We conclude that in the CBA of the CIR rats the protective effect of TFR on ischemic cerebrovascular injury may be related to the activation of the TRPV4 in both endothelium and smooth muscle by increasing its expression and activity. The activation of TRPV4 channel in the endothelium may be linked to the opening of endothelial IKca/SKca channels that induces EDHF-mediated relaxation and hyperpolarization in the smooth muscle cell. In addition, the activation of TRPV4 in the smooth muscle cell in CBA may be linked with the activation of BKCa channel through a TRPV4-dependent pathway, reduce Ca2+ concentration ...
Source: Evidence-based Complementary and Alternative Medicine - November 10, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Investigation of the Antidiarrheal and Antimicrobial Activities of 80% Methanolic Leaf Extract of Discopodium Penninervum (Hochst.).
Authors: Derebe D, Abdulwuhab M, Wubetu M, Mohammed F Abstract Diarrhea is a major health problem throughout the world and it has become more problematic in developing countries like Ethiopia. People, in several parts of the world, use different traditional medicines for treating diarrhea and it has been reported that the roots, leaves, and flowers of various species are used for the same purpose. In Ethiopia, for instance, Discopodium Penninervum is used for the treatment of diarrhea and also to control infection. The aim of the present study was, therefore, to evaluate the in vivo antidiarrheal and in vitro antim...
Source: Evidence-based Complementary and Alternative Medicine - November 8, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Inhibitory Effects of Prunella vulgaris L. Extract on 11 β-HSD1 in Human Skin Cells.
In this study, we investigated the inhibitory effect of Prunella vulgaris L. extract (PVE) and the underlying mechanism of 11β-HSD11 inhibition. Consistent with these results, cortisol levels were also reduced by PVE in vitro. The cortisone-induced translocation of glucocorticoids receptor (GR) was also attenuated. In addition, PVE inhibited a cortisone-mediated decrease in collagen content in skin. Collectively, these results suggest the beneficial effects of PVE in maintaining skin integrity. PMID: 30402116 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - November 8, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

An Ethanolic Extract of Allium hookeri Root Alleviates Reflux Esophagitis and Modulates NF- κB Signaling.
An Ethanolic Extract of Allium hookeri Root Alleviates Reflux Esophagitis and Modulates NF-κB Signaling. Evid Based Complement Alternat Med. 2018;2018:1834681 Authors: Nan L, Nam HH, Choo BK, Park JC, Kim DG, Lee JH, Moon KH Abstract Reflux esophagitis (RE) is a kind of gastroesophageal reflux disease, of which an esophageal inflammatory lesion is caused by the contents of the stomach and duodenum flowing back into the esophagus. Allium hookeri is a plant possessing both nutritional and medicinal properties. In our study, we investigated the inhibition effect of inflammation of A. hookeri root ex...
Source: Evidence-based Complementary and Alternative Medicine - November 8, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Bushenhuoxue Formula Facilitates Articular Cartilage Repair and Attenuates Matrix Degradation by Activation of TGF- β Signaling Pathway.
Conclusion: By activation of TGF-β signaling, BSHX formula can promote articular cartilage repair by accelerating chondrocyte proliferation and maintaining chondrocyte phenotype, upregulate ECM accumulation, and inhibit matrix degradation. PMID: 30402118 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - November 8, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Association of Cold-Heat Patterns with Tongue Features, Body Composition, Anthropometric Indices, and Blood Parameters in Tae-Eum Type.
Conclusions: This study found that cold and heat patterns were significantly associated with body composition, anthropometric indices, blood parameters, and tongue features. We suggest that these factors could thus be used as objective indicators and predictors of cold-heat patterns. Our findings provide fundamental but also applicable data that will be useful for diagnosing and monitoring cold-heat patterns in Tae-Eum type patients. PMID: 30402119 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - November 8, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Investigation on the Antibacterial and Anti-T3SS Activity of Traditional Myanmar Medicinal Plants.
This study provided the first scientific evidence of T3SS prohibiting and antibacterial properties for the traditional knowledge in Myanmar of using plants as medicines for treating infections and gastrointestinal disease. Further researches are proposed to discover the active chemical compounds and mechanism of L. scandens (Roxb.) Buch.-Ham. ex Wight & Arn, M. nagi Thunb., T. citrina Roxb. ex Fleming, T. vulgaris L., and C. bejolghota (Buch.-Ham.) Sweet as antivirulence drugs and the potential of M. gagei J.R.Drumm and M. ferrea L. as new broad spectrum plant antibiotics. PMID: 30402120 [PubMed] (Source: Evidence-...
Source: Evidence-based Complementary and Alternative Medicine - November 8, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Hyperthermic Effect of Ginger (Zingiber officinale) Extract-Containing Beverage on Peripheral Skin Surface Temperature in Women.
Authors: Sugimoto K, Takeuchi H, Nakagawa K, Matsuoka Y Abstract Ginger is known to warm the body. Therefore, we conducted a placebo-controlled crossover trial to investigate the hyperthermic effect of a palatable ginger-containing beverage in healthy women with cold-sensitive extremities. Six women drank 280 mL of 0.07% ginger extract-containing or placebo beverage in a temperature-controlled room (21°C). Their palm temperatures were measured as measure of surface body temperature using a thermographic camera before intake and every 10 min after intake for 60 min. Palm temperature increase...
Source: Evidence-based Complementary and Alternative Medicine - November 8, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Anti-Angiogenic Alternative and Complementary Medicines for the Treatment of Endometriosis: A Review of Potential Molecular Mechanisms.
Authors: Zheng W, Cao L, Xu Z, Ma Y, Liang X Abstract Endometriosis is caused by the growth or infiltration of endometrial tissues outside of the endometrium and myometrium. Symptoms include pain and infertility. Surgery and hormonal therapy are widely used in Western medicine for the treatment of endometriosis; however, the side effects associated with this practice include disease recurrence and menopause, which can severely influence quality of life. Angiogenesis is the main biological mechanism underlying the development of endometriosis. Numerous natural products and Chinese medicines with potent anti-angiogen...
Source: Evidence-based Complementary and Alternative Medicine - November 8, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Traditional Chinese Medicine Injections in the Treatment of Diabetic Foot: A Systematic Review and Meta-Analysis.
Authors: Tan L, Shi Q, Liu C, Zhang J, Wang H, Zhai J Abstract Context: The role of traditional Chinese medicine injections (TCMIs) in diabetic foot (DF) has not been well estimated. Objective: To evaluate the clinical effective rate, safety, and the financial cost of TCMIs in treating DF and ulcer wound healing. Methods: We searched PubMed, Embase, CENTRAL, China National Knowledge Infrastructure (CNKI), VIP database, and Wanfang database from inception to May 2018 to find all randomized control trials (RCTs) related to TCMIs in DF treatment. The search items were "Traditional Chinese Medicine Injecti...
Source: Evidence-based Complementary and Alternative Medicine - November 8, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Electrochemically Reduced Water Delays Mammary Tumors Growth in Mice and Inhibits Breast Cancer Cells Survival In Vitro.
In this study, we show that ERW treatment of MCF-7, MDA-MB-453, and mouse (TUBO) breast cancer cells inhibited cell survival in a time-dependent fashion. ERW decreased ErbB2/neu expression and impaired pERK1/ERK2 and AKT phosphorylation in breast cancer cells. In addition, ERW treatment induced apoptosis of breast cancer cell lines independently of the status of p53 and ER and PR receptors. Our in vivo results showed that ERW treatment of transgenic BALB-neuT mice delayed the development of mammary tumors compared to the control. In addition, ERW induced a significant prolongation of tumor-free survival and a reduction in ...
Source: Evidence-based Complementary and Alternative Medicine - November 8, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Protective Effects of Chinese Traditional Medicine Longhu Rendan against Atherosclerosis via Negative Regulation of LOX-1.
In conclusion, LHRD could significantly attenuate experimental atherosclerosis and might be a novel potential drug for the prevention and treatment of atherosclerosis. PMID: 30402125 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - November 8, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Erchen Decoction Ameliorates Lipid Metabolism by the Regulation of the Protein CAV-1 and the Receptors VLDLR, LDLR, ABCA1, and SRB1 in a High-Fat Diet Rat Model.
Authors: Ding S, Kang J, Tong L, Lin Y, Liao L, Gao B Abstract Lipid metabolism disorder is a common metabolic disorder characterized by abnormal lipid levels in blood. Erchen decoction (ECD) is a traditional Chinese medicine prescription, which is used for the treatment of diseases caused by retention of phlegm dampness. It has been reported to ameliorate the disorder of lipid metabolism. The aim of the present study was to investigate the effects and underlying mechanisms of ECD in lipid metabolism disorder induced by a high-fat diet (HFD) in rats. ECD (4.35g/kg/d) and atorvastatin (10mg/kg/d, positive control) w...
Source: Evidence-based Complementary and Alternative Medicine - November 8, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Yellow Laser Stimulation at GV2 Acupoint Mitigates Apoptosis, Oxidative Stress, Inflammation, and Motor Deficit in Spinal Cord Injury Rats.
Authors: On-Ong-Arj P, Wattanathorn J, Muchimapura S, Thukham-Mee W Abstract Currently, the suppression of oxidative stress and inflammation is considered as the treatment targets of spinal cord injury due to their roles on the hindrance of recovery process. Since laser acupuncture decreased oxidative stress and enhanced the survival of neurons from oxidative stress damage and GV2 stimulation was selected as one stimulated acupoint in order to enhance the recovery of spinal cord injury, we hypothesized that laser acupuncture at GV2 should enhance the recovery of spinal cord injury. To test this hypothesis, male Wis...
Source: Evidence-based Complementary and Alternative Medicine - November 8, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Genotoxicity Evaluation of an Ethanol Extract Mixture of Astragali Radix and Salviae miltiorrhizae Radix.
Authors: Lee JS, Cho JH, Lee DS, Son CG Abstract Myelophil, a combination of Astragali Radix and Salviae Radix, is one of the most commonly used remedies for disorders of Qi and blood in traditional Chinese medicine. Based on the clinical applications of these plants, in particular to pregnant woman, this study aimed to evaluate the genotoxic potential of an ethanol extract mixture of the above two herbs, called Myelophil. Following the Organization for Economic Cooperation and Development (OECD) Guideline methods, a genotoxicity test was conducted using a bacterial reverse mutation test with Salmonella typhimurium...
Source: Evidence-based Complementary and Alternative Medicine - November 8, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Effects of Cinnamaldehyde on the Cell Wall of A. fumigatus and Its Application in Treating Mice with Invasive Pulmonary Aspergillosis.
Authors: Deng J, Wang G, Li J, Zhao Y, Wang X Abstract Background: The invasive pulmonary aspergillosis is a kind of high incidence of disease with difficulties in treatment, poor prognosis, and high mortality. Objectives: The study aimed to reveal the effect of cinnamaldehyde on the fungal cell wall and verify its efficacy on invasive pulmonary aspergillosis on immunosuppressed Institute of Cancer Research mice (ICR mice). Methods: ICR mice were given cyclophosphamide 200 mg.kg-1. d-1 by intraperitoneal injection for 2 days. On the 4th day, the mice were given 50 μL of Aspergillosis fumigatus spo...
Source: Evidence-based Complementary and Alternative Medicine - November 8, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Sheng-Jiang Powder Ameliorates High Fat Diet Induced Nonalcoholic Fatty Liver Disease via Inhibiting Activation of Akt/mTOR/S6 Pathway in Rats.
Conclusions: SJP is efficient in attenuating HFD induced NAFLD in rats and this effect might be partly related to the inhibition of Akt/mTOR/S6 pathway. PMID: 30402130 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - November 8, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Plants Used as Anticancer Agents in the Ethiopian Traditional Medical Practices: A Systematic Review.
Conclusion: The review showed that anticancer MPs are widely used across the regions of Ethiopia. Most of the MPs are not scientifically experimented and yet are at a higher vulnerability to loss mainly by human activities. Calling for conservation measures, we recommend experimental validation of the frequently used anticancer MPs. This augments global anticancer drug researches. PMID: 30402131 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - November 8, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Protective Effect of Electroacupuncture at Zusanli on Myocardial Injury in Septic Rats.
Authors: Zhang L, Huang Z, Shi X, Hu S, Litscher D, Wang L, Litscher G Abstract The protective effect of electroacupuncture (EA) at Zusanli points (ST36) on myocardial injury in a model of sepsis was observed. Forty-eight male Sprague-Daley rats were subjected to sepsis by cecal ligation and puncture (CLP) and randomly divided into 4 groups (n=12; A: sepsis + EA; B: sepsis + sham acupuncture; C: sepsis + vagotomy; D: sepsis + vagotomy + EA). Bilateral points were stimulated (2mA, 2-100 Hz) for 1 hour. Abdominal vagotomy was performed in groups C and D. At 6h after CLP, the plasma activity of creatine kinase-MB (CK-...
Source: Evidence-based Complementary and Alternative Medicine - November 8, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Baicalin Exerts Anti-Airway Inflammation and Anti-Remodelling Effects in Severe Stage Rat Model of Chronic Obstructive Pulmonary Disease.
Authors: Wang G, Mohammadtursun N, Lv Y, Zhang H, Sun J, Dong J Abstract Chronic obstructive pulmonary disease (COPD) is a worldwide epidemic. Current approaches are disappointing due to limited improvement of the disease development. The present study established 36-week side stream cigarette smoke induced rat model of COPD with advanced stage feature and evaluted the effects of baicalin on the model. Fifty-four Sprague-Dawley rats were randomly divided into six groups including room air control, cigarette smoke exposure, baicalin (40 mg/kg, 80 mg/kg, and 160 mg/kg), and budesonide used as a positive control. Rats...
Source: Evidence-based Complementary and Alternative Medicine - November 8, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Immunostimulatory Effect of Zanthoxylum schinifolium-Based Complex Oil Prepared by Supercritical Fluid Extraction in Splenocytes and Cyclophosphamide-Induced Immunosuppressed Rats.
Authors: Lee HY, Park YM, Lee YH, Kang YG, Lee HM, Park DS, Yang HJ, Kim MJ, Lee YR Abstract Complex oil of Zanthoxylum schinifolium and Perilla frutescens seed (ZPCO) is used as a traditional medicine due to its pharmacological activities. The aim of this study was to investigate the immunostimulatory effect of ZPCO in isolated splenocytes as well as in an immunosuppressed rat model, which was generated via oral administration of cyclophosphamide. Notably, our results showed that ZPCO exerted an immunity-enhancing effect both in vitro and in vivo. Specifically, ZPCO treatment enhanced the viability and inflammator...
Source: Evidence-based Complementary and Alternative Medicine - November 8, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Bu Shen Yang Xue Prescription Has Treating Effect on Endometrial Cancer through FSH/PI3K/AKT/Gankyrin/HIF- α/cyclinD 1 Pathway in Ishikawa Cells.
Conclusions. Taken together, our results showed that the formulation of BSYX had antitumor effect on endometrial cancer in vivo and in vitro and was related with FSH/PI3K/AKT/Gankyrin/HIF-α/cyclinD1 transduction pathway. PMID: 30402135 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - November 8, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Does Electroacupuncture Treatment Reduce Pain and Change Quantitative Sensory Testing Responses in Patients with Chronic Nonspecific Low Back Pain? A Randomized Controlled Clinical Trial.
Authors: Leite PMS, Mendonça ARC, Maciel LYS, Poderoso-Neto ML, Araujo CCA, Góis HCJ, Souza JHS, DeSantana JM Abstract Chronic nonspecific low back pain is common and one of the most disabling conditions in the world. There is moderate evidence that chronic low back pain patients present altered functional connectivity in areas related to pain processing. Quantitative sensory testing is a way of clinical measure of these alterations. Although there is not enough evidence, there are some reports that electroacupuncture is supposedly more effective in relieving pain than acupuncture because the addition...
Source: Evidence-based Complementary and Alternative Medicine - November 8, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Exploring Pharmacological Mechanisms of Xuefu Zhuyu Decoction in the Treatment of Traumatic Brain Injury via a Network Pharmacology Approach.
Conclusion: Our work successfully illuminates the "multicompounds, multitargets" therapeutic action of XFZYD in the treatment of TBI by network pharmacology with molecule docking method. The present work may provide valuable evidence for further clinical application of XFZYD as therapeutic strategy for TBI treatment. PMID: 30402137 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - November 8, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Antihyperglycemic and Antilipidemic Effects of the Ethanol Extract Mixture of Ligularia fischeri and Momordica charantia in Type II Diabetes-Mimicking Mice.
In conclusion, antihyperglycemic and antihyperlipidemic effects were strengthened by the combined extracts of L. fischeri and M. charantia (MLM) in diabetes-mimicking mice. PMID: 30386403 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - November 4, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Hydroalcoholic Extract and Ethyl Acetate Fraction of Bixa orellana Leaves Decrease the Inflammatory Response to Mycobacterium abscessus Subsp. massiliense.
This study evaluated the antimicrobial and anti-inflammatory activities of a hydroalcoholic extract (BoHE) and ethyl acetate fraction (BoEA) of Bixa orellana leaves. Antimicrobial activity was evaluated by broth microdilution to determine the minimum inhibitory (MIC) and the minimum bactericidal (MBC) concentrations. Cytotoxicity was evaluated using erythrocytes and RAW 264.7 cells. Nitric oxide (NO) was assayed in stimulated RAW 264.7 cells, and inflammatory cell migration and acute toxicity were evaluated in a Mabs-induced peritonitis mouse model. The compounds present in BoEA were identified by high performance liquid c...
Source: Evidence-based Complementary and Alternative Medicine - October 31, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Effect of Total Flavones from Cuscuta Chinensis on Anti-Abortion via the MAPK Signaling Pathway.
In this study, we aim at characterizing the anti-abortion effects of TFCC and its underlying molecular mechanism in vitro and in vivo using human primary decidua cells and a mifepristone-induced abortion model in rat, respectively. The damage to the decidua caused by mifepristone in vivo was reversed by TFCC treatment in a dosage-dependent manner. High dosage of TFCC significantly upregulated the expression of estrogen receptor (ER), progesterone receptor (PR), and prolactin receptor (PRLR) in decidua tissue but downregulated the expression of p-ERK. Furthermore, we detected higher level of p-ERK and p-p38 in primary decid...
Source: Evidence-based Complementary and Alternative Medicine - October 31, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Traditional Chinese Medicine Syndrome Patterns and Their Association with Hepatitis B Surface Antigen Levels during the Natural History of Chronic Hepatitis B Virus Infection.
Authors: Xie HP, Liu ZP, Zhang JS, Dai M, Xiao GM, Wu WK, Yang HZ Abstract The aim of this study is to investigate traditional Chinese medicine syndrome (TCMS) patterns and their association with hepatitis B surface antigen (HBsAg) levels during the natural history of chronic hepatitis B virus infection (CHB). Patients were categorized according to the phase of CHB, as follows: immune tolerance (ITP); immune clearance (ICP); low or nonreplication (LRP); reactivation (RAP); hepatic cirrhosis (HC); and primary liver cancer (PLC). TCMS patterns were classified among the following types: spleen-kidney deficiency (SKD);...
Source: Evidence-based Complementary and Alternative Medicine - October 31, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Hepatoprotective and Antioxidant Activities of Oil from Baru Almonds (Dipteryx alata Vog.) in a Preclinical Model of Lipotoxicity and Dyslipidemia.
Authors: Reis MÁ, Novaes RD, Baggio SR, Viana ALM, Salles BCC, Duarte SMDS, Rodrigues MR, Paula FBA Abstract The oil obtained from baru (Dipteryx alata Vog.) almonds exhibits high energy value and is reported in popular medicine for the treatment of rheumatic diseases and reproductive disturbances. Although baru oil is used in domestic cuisine, the chemical characterization of this oil and its effects on lipid metabolism are still poorly understood. Therefore, this study evaluated the fatty acid (FA) profile and the effects of baru oil on liver and aorta in a murine model of dyslipidemia. The chromatographic...
Source: Evidence-based Complementary and Alternative Medicine - October 31, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Tongue Image Database Construction Based on the Expert Opinions: Assessment for Individual Agreement and Methods for Expert Selection.
This study aims at introducing a method for individual agreement evaluation to identify the discordant raters from the experts' group. We exclude those experts and decide the best experts selection method, so as to improve the reliability of the constructed tongue image database based on experts' opinions. Fifty experienced experts from the TCM diagnostic field all over China were invited to give ratings for 300 randomly selected tongue images. Gwet's AC1 (first-order agreement coefficient) was used to calculate the interrater and intrarater agreement. The optimization of the interrater agreement and the disagreement score...
Source: Evidence-based Complementary and Alternative Medicine - October 31, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Metabolomics Analysis of the Lipid-Regulating Effect of Allium hookeri in a Hamster Model of High-Fat Diet-Induced Hyperlipidemia by UPLC/ESI-Q-TOF Mass Spectrometry.
Authors: Jang GJ, Sung MJ, Hur HJ, Yoo M, Choi JH, Hwang IK, Lee S Abstract Hyperlipidemia is a risk factor for atherosclerotic cardiovascular disease and is a major public health concern. Allium hookeri (AH) is an Allium species containing high levels of bioactive organosulfur compounds such as methiin and cycloalliin. AH exerts hypolipidemic effects in animals fed a high-fat diet. However, there exists little information on the mechanisms underlying these effects. To address this issue, we used a metabolomic approach based on ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry to i...
Source: Evidence-based Complementary and Alternative Medicine - October 28, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Natural Foods from Plant Sources in Preventing Nontransmissible Diseases.
Authors: Wanderley AG, Singh Dahiya R, De Andrade SF PMID: 30363684 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - October 28, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Therapeutic Effectiveness of Galphimia glauca in Young People with Social Anxiety Disorder: A Pilot Study.
In conclusion, the 10-week oral administration of G. glauca standardized extract showed efficacy and safety in patients with social anxiety disorder, without showing a significant difference from patients treated with sertraline. PMID: 30363731 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - October 28, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Acupuncture Treatment for Chronic Pelvic Pain in Women: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Conclusions: This review suggests the potential of AT combined with CT compared to CT alone for treating female CPP. However, there is insufficient evidence to conclude that AT can be recommended as a complementary and alternative (CAM) treatment for women with CPP. To draw a firm conclusion, future studies should require not only lager, more rigorously designed RCTs but also research on different AT types. Protocol Registration Number: This study is registered with PROSPERO 2018 (CRD42018088627). PMID: 30363734 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - October 28, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

The Internal Coherence of Breast Cancer Patients Is Associated with the Decision-Making for Chemotherapy and Viscum album L. Treatment.
Authors: Oei SL, Thronicke A, Kröz M, Herbstreit C, Schad F Abstract Objective: In the present observational study, the influence of internal coherence on shared decision-making for chemotherapy (CTX) and Viscum album L. extracts (VA) treatment in breast cancer patients was evaluated. Methods: Breast cancer patients with a guideline-oriented advice from the tumor board for CTX were included in the study. At first diagnosis (T0) and 6 months later (T1), a questionnaire, the internal coherence scale (ICS), was administered and evaluated. Prior to analysis, patients were classified retrospectively depending o...
Source: Evidence-based Complementary and Alternative Medicine - October 28, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Utilization Pattern of Traditional Chinese Medicine among Fracture Patients: A Taiwan Hospital-Based Cross-Sectional Study.
This study aims to identify the CHPs that should be used at different periods of treatment as well as confirm the TCM theory of fracture periods medicine. We used prescriptions of TCM outpatients with fracture diagnoses analyzed using the Chang Gung Research Database (CGRD) from 2000 to 2015. According to the number of days between the date of the fracture and the clinic visit date, all patients were assigned to one of three groups. Patients with a date gap of 0-13 days were assigned to the early period group; those with a date gap of 14-82 days were assigned to the middle period group; and those with a date gap of 83-182 ...
Source: Evidence-based Complementary and Alternative Medicine - October 28, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Green Tea Polyphenols and Padma Hepaten Inhibit Candida albicans Biofilm Formation.
In this study, we examined whether the polyphenol rich extractions Polyphenon from green tea (PPFGT) and Padma Hepaten (PH) can inhibit the caries-inducing properties of C. albicans. Biofilms of C. albicans were grown in the presence of PPFGT and PH. Formation of biofilms was tested spectrophotometrically after crystal violet staining. Exopolysaccharides (EPS) secretion was quantified using confocal scanning laser microscopy (CSLM). Treated C. albicans morphology was demonstrated using scanning electron microscopy (SEM). Expression of virulence-related genes was tested using qRT-PCR. Development of biofilm was also tested ...
Source: Evidence-based Complementary and Alternative Medicine - October 28, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Acupuncture and Related Therapies for Obesity: A Network Meta-Analysis.
Authors: Zhang Y, Li J, Mo G, Liu J, Yang H, Chen X, Liu H, Cai T, Zhang X, Tian X, Zhou Z, Huang W Abstract Obesity is a worldwide public health problem. Currently, increasing evidence suggests acupuncture and related therapies are effective for obesity. This network meta-analysis (NMA) was performed to compare the effectiveness of different acupuncture and related therapies. We searched potential randomized controlled trials (RCTs) in three international databases. Thirty-four trials involving 2283 participants were included. Pairwise meta-analysis showed that acupuncture and related therapies were superior to li...
Source: Evidence-based Complementary and Alternative Medicine - October 28, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Squalene Stimulates a Key Innate Immune Cell to Foster Wound Healing and Tissue Repair.
Authors: Sánchez-Quesada C, López-Biedma A, Toledo E, Gaforio JJ Abstract Anti-inflammatory effects of virgin olive oil (VOO) have been described recently, along with its wound healing effect. One of the main minor compounds found in VOO is squalene (SQ), which also possesses preventive effects against skin damage and anti-inflammatory properties. The inflammatory response is involved in wound healing and manages the whole process by macrophages, among others, as the main innate cells with a critical role in the promotion and resolution of inflammation for tissue repair. Because of that, this work is ...
Source: Evidence-based Complementary and Alternative Medicine - October 28, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

An Herbal Medicine, Yukgunja-Tang is more Effective in a Type of Functional Dyspepsia Categorized by Facial Shape Diagnosis: A Placebo-Controlled, Double-Blind, Randomized Trial.
Conclusion: YGJT may be considered for FD patients diagnosed with BB subtype using 3-FSDS. PMID: 30363994 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - October 28, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Gynura procumbens Improved Fertility of Diabetic Rats: Preliminary Study of Sperm Proteomic.
In conclusion, GP treatment effectively treats infertility of male diabetic rats, possibly through the upregulation of proteins related to sperm maturation and sperm-egg interaction. PMID: 30363997 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - October 28, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research