Protective Effects of Astragaloside IV on Uric Acid-Induced Pancreatic < em > β < /em > -Cell Injury through PI3K/AKT Pathway Activation
CONCLUSION: Collectively, our data suggest that AS-IV protected pancreatic β-cells from UA-treated dysfunction by activating the PI3K/AKT pathway. Such findings suggest that AS-IV may be an efficient natural agent against T2D.PMID:35047042 | PMC:PMC8763508 | DOI:10.1155/2022/2429162 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - January 20, 2022 Category: Complementary Medicine Authors: Zhenhuan Jiang Gang Wang Lingling Meng Yunzhao Tang Min Yang Changlin Ni Source Type: research

Clinical Efficacy Evaluation and Potential Mechanism of Zhishe Tongluo Capsule in the Treatment of Cerebral Infarction by Meta-Analysis Associated with Network Pharmacology
Evid Based Complement Alternat Med. 2022 Jan 10;2022:2471927. doi: 10.1155/2022/2471927. eCollection 2022.ABSTRACTOBJECTIVE: By integrating meta-analysis and network pharmacology strategy, the clinical efficacy of Zhishe Tongluo capsule in the treatment of cerebral infarction was evaluated, and the intervention mechanism was preliminary explored.METHODS: Through meta-analysis, the Chinese and English literature of the randomized controlled trial (RCT) of Zhishe Tongluo capsule in the treatment of cerebral infarction was comprehensively searched. Based on the standard of Na Pai, the quantitative literature was determined an...
Source: Evidence-based Complementary and Alternative Medicine - January 20, 2022 Category: Complementary Medicine Authors: Zhi Xin Geng Feng Gao Junjing Guo Bingzhou Guo Chunyu Liu Taiwei Dong Min Li Yang Bai Peifeng Wei Source Type: research

Acupuncture Therapy on Patients with Flaccid Hemiplegia after Stroke: A Systematic Review and Meta-Analysis
Evid Based Complement Alternat Med. 2022 Jan 10;2022:2736703. doi: 10.1155/2022/2736703. eCollection 2022.ABSTRACTBACKGROUND: Acupuncture is a commonly used complementary treatment for flaccid hemiplegia caused by stroke, but evidences from previous randomized trials were inconclusive. The purpose of this study was to evaluate the efficacy and safety of acupuncture in a comprehensive synthesis.METHODS: We searched literature from eight databases from their inception to December 2020. We included randomized controlled trials of acupuncture for the treatment of flaccid hemiplegia following stroke. The meta-analysis was carri...
Source: Evidence-based Complementary and Alternative Medicine - January 20, 2022 Category: Complementary Medicine Authors: Yang Tu Wei Peng Jun Wang QingHong Hao Yang Wang Hui Li TianMin Zhu Source Type: research

Development of a Hepatoprotective Herbal Drug from < em > Turnera diffusa < /em >
Evid Based Complement Alternat Med. 2022 Jan 10;2022:5114948. doi: 10.1155/2022/5114948. eCollection 2022.ABSTRACTThe incidence of liver diseases, such as nonalcoholic fatty liver disease and drug-induced liver injury, continues to rise and is one of the leading causes of acute hepatitis. Current trends suggest that these types of conditions will increase in the coming years. There are few drugs available for the prevention or treatment of hepatic diseases, and there is a growing need for the development of safe hepatoprotective agents. The medicinal plant, Turnera diffusa, has many ethnopharmacological uses, one of which ...
Source: Evidence-based Complementary and Alternative Medicine - January 20, 2022 Category: Complementary Medicine Authors: Cecilia Delgado-Montemayor Paula Cordero-P érez Liliana Torres-Gonz ález Mar ía de la L Salazar-Cavazos Alma L Saucedo David Paniagua-Vega Noem í H Waksman-Minsky Source Type: research

3 < em > β < /em > ,23-Dihydroxy-12-ene-28-ursolic Acid Isolated from < em > Cyclocarya paliurus < /em > Alleviates NLRP3 Inflammasome-Mediated Gout via PI3K-AKT-mTOR-Dependent Autophagy
In conclusion, these findings suggested that compound 2 may effectively improve NLRP3 inflammasome-mediated gout via PI3K-AKT-mTOR-dependent autophagy and could be further investigated as a potential agent against gout.PMID:35047046 | PMC:PMC8763513 | DOI:10.1155/2022/5541232 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - January 20, 2022 Category: Complementary Medicine Authors: Dongxiao Lou Xiaogai Zhang Cuihua Jiang Fang Zhang Chao Xu Shengzuo Fang Xulan Shang Jian Zhang Zhiqi Yin Source Type: research

Elaborate the Mechanism of Ancient Classic Prescriptions (Erzhi Formula) in Reversing GIOP by Network Pharmacology Coupled with Zebrafish Verification
Evid Based Complement Alternat Med. 2022 Jan 10;2022:7019792. doi: 10.1155/2022/7019792. eCollection 2022.ABSTRACTOsteoporosis is a degenerative disease that endangers human health. At present, chemical drugs used for osteoporosis have serious side effects. Therefore, it is valuable to search herbs with high safety and good curative effect in antiosteoporosis. Erzhi formula (EZF), an ancient classic compound, has been reported to have a beneficial effect in antiosteoporosis, but its mechanism is unclear. In this paper, the active compounds of EZF were found in Systems Pharmacology Database, and gene targets related to oste...
Source: Evidence-based Complementary and Alternative Medicine - January 20, 2022 Category: Complementary Medicine Authors: Zhihui Cai Huajun Wang Jun Jiang Shichang Xiao Jianpeng Xiao Jinjin He Zihan Zhao Jiangning Yin Source Type: research

< em > In Vitro < /em > Assessment of the Cercaricidal Activity of < em > Sida acuta < /em > Burm. F. and < em > Sida rhombifolia < /em > Linn. (Malvaceae) Hydroethanolic Extracts, Cytotoxicity, and Phytochemical Studies
This study could provide baseline information for further investigations aiming to develop plant-based alternative drugs against S. mansoni.PMID:35047048 | PMC:PMC8763507 | DOI:10.1155/2022/7281144 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - January 20, 2022 Category: Complementary Medicine Authors: Ulrich Membe Femoe Joseph Bertin Kadji Fassi Hermine Boukeng Jatsa Yannick Leonel Tchoffo David Carel Amvame Nna Blaise C édric Kamdoum Steven Collins Njonte Wouamba Billy Toussie Tchegnitegni Bonaventure Tchaleu Ngadjui Norbert Sewald Bruno Ndjakou Lent Source Type: research

Prevalence and Risk Factors Comparison of Anterior and Posterior Intracranial Arterial Stenosis
Evid Based Complement Alternat Med. 2022 Jan 10;2022:7710374. doi: 10.1155/2022/7710374. eCollection 2022.ABSTRACTThe prevalence and risk factors of intracranial atherosclerotic stenosis (ICAS) located in the anterior circulation (AC) and posterior circulation (PC) has been scarcely noted in the general population. We aimed to determine ICAS prevalence and risk factor profile of AC and PC in a representative population. Data were from the China Hypertension Survey of Beijing. In total, 4800 people aged 35 years or older were enrolled in this subsurvey for ICAS, and 3954 participants were eligible for analysis. ICAS was ass...
Source: Evidence-based Complementary and Alternative Medicine - January 20, 2022 Category: Complementary Medicine Authors: Yan Zhao Beibei Liu Chunxiu Wang Shaochen Guan Chunxiao Liu Yanlei Zhang Chengbei Hou Xiaowei Song Zhongying Zhang Xiaoguang Wu Huihui Li Xiang Gu Shimin Hu Jian Wu Xianghua Fang Source Type: research

Quanzhenyiqitang Reverses LPS-Induced Inflammation via Inhibiting PYK2/p38MAPK/HDAC2/CK2 Signaling Pathway in Rat Alveolar Macrophage
In this study, transfection, flow cytometry, QRT-PCR, and Western blotting methods were used to study the mechanism of Quanzhenyiqitang lipopolysaccharide-induced lung injury. The results showed that the mechanism of occurrence remains unclear. Our novel observations imply that the PYK2/p38MAPK/HDAC2/CK2 pathway is one of the fundamental underlying mechanisms that mediate the pathogenic progression of COPD, and Quanzhenyiqitang may be the therapeutic drug to prevent chronic inflammation and delay the progression of COPD by inhibiting PYK2 signaling pathways.PMID:35047050 | PMC:PMC8763520 | DOI:10.1155/2022/7857022 (Source:...
Source: Evidence-based Complementary and Alternative Medicine - January 20, 2022 Category: Complementary Medicine Authors: Ke-Qiang Chen Da-Zhi Li Zhi-Bin Chen Chuan-Lin Zhang Bin-Can Wang Chun-E Wang Source Type: research

Clinical Effectiveness and Safety of Chinese Herbal Medicine Compound Kushen Injection as an Add-On Treatment for Breast Cancer: A Systematic Review and Meta-Analysis
Conclusions about PFS and OS could not be drawn due to lack of evidence. Additionally, CKI appeared to relieve the risk of ADRs in patients with breast cancer receiving chemotherapies. However, due to weak evidence, the findings should be further confirmed in large and rigorous trials.PMID:35047051 | PMC:PMC8763510 | DOI:10.1155/2022/8118408 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - January 20, 2022 Category: Complementary Medicine Authors: Bao-Yong Lai Ai-Jing Chu Bo-Wen Yu Li-Yan Jia Ying-Yi Fan Jian-Ping Liu Xiao-Hua Pei Source Type: research

Lanzhang Granules Ameliorate Nonalcoholic Fatty Liver Disease by Regulating the PPAR < em > α < /em > Signaling Pathway
CONCLUSION: LZG can improve NAFLD in mice or cell models. A major underlying mechanism may be the regulation of the PPARα signaling pathway to improve lipid metabolism and inhibit the inflammatory response. This study will help to promote the clinical application of LZG for the treatment of NAFLD.PMID:35035496 | PMC:PMC8759917 | DOI:10.1155/2022/1124901 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - January 17, 2022 Category: Complementary Medicine Authors: Ping Huang Lili Yang Yang Liu Yuwei Jiang Yiping Li Zhiwei Chen Haiyan Song Peiyong Zheng Source Type: research

Overview of Microvascular Angina Pectoris and Discussion of Traditional Chinese Medicine Intervention
Evid Based Complement Alternat Med. 2022 Jan 5;2022:1497722. doi: 10.1155/2022/1497722. eCollection 2022.ABSTRACTPrevious research and treatment of coronary heart disease mostly focused on the large epicardial vessels, with limited research on the small endocardial coronary arteries or arterioles that could not be detected by coronary angiography, especially microvascular angina caused by microvascular stenosis or microcirculation dysfunction. Conventional Western medicine therapies have no specific efficacy, but traditional Chinese medicine has significant advantages in this regard. In particular, traditional Chinese medi...
Source: Evidence-based Complementary and Alternative Medicine - January 17, 2022 Category: Complementary Medicine Authors: Linghua Yu Xiaoyan Lu Chenxi Xu Tong Li Yanling Wang Anxiang Liu Yubi Wang Li Chen Huangyu Xu Source Type: research

Pharmacological Mechanisms of Tinglizi against Chronic Heart Failure Determined by Network Pharmacology and Molecular Docking
Evid Based Complement Alternat Med. 2022 Jan 6;2022:2152399. doi: 10.1155/2022/2152399. eCollection 2022.ABSTRACTOBJECTIVE: Tinglizi has been extensively used to treat chronic heart failure (CHF) in modern times, but the material basis and pharmacological mechanisms are still unclear. To explore the material basis and corresponding potential targets and to elucidate the mechanism of Tinglizi, network pharmacology and molecular docking methods were utilized.METHODS: The main chemical compounds and potential targets of Tinglizi were collected from the pharmacological database analysis platform (TCMSP). The corresponding gene...
Source: Evidence-based Complementary and Alternative Medicine - January 17, 2022 Category: Complementary Medicine Authors: Liangtao Luo Haowen Wang Guowei Huang Lu Zhang Xiuwei Li Chongyang Ma Xing Wang Source Type: research

A Study of the Protective Effect of Bushen Huoxue Prescription on Cerebral Microvascular Endothelia Based on Proteomics and Bioinformatics
Evid Based Complement Alternat Med. 2022 Jan 6;2022:2545074. doi: 10.1155/2022/2545074. eCollection 2022.ABSTRACTDiabetic cognitive dysfunction is a serious complication of type 2 diabetes mellitus (T2DM), which can cause neurological and microvascular damage in the brain. At present, there is no effective treatment for this complication. Bushen Huoxue prescription (BSHX) is a newly formulated compound Chinese medicine containing 7 components. Previous research indicated that BSHX was neuroprotective against advanced glycosylation end product (AGE)-induced PC12 cell insult; however, the effect of BSHX on AGE-induced cerebr...
Source: Evidence-based Complementary and Alternative Medicine - January 17, 2022 Category: Complementary Medicine Authors: Shao-Yang Zhao Huan-Huan Zhao Yi-Ming Li Bao-Hua Wang Sai-Mei Li Source Type: research

Effects of Integrated Chinese Traditional Medicine and Conventional Western Medicine on the Quality of Life of Breast Cancer Patients: A Systematic Review and Meta-Analysis
Evid Based Complement Alternat Med. 2022 Jan 7;2022:3123878. doi: 10.1155/2022/3123878. eCollection 2022.ABSTRACTBACKGROUND: Traditional Chinese medicine has been widely used, in conjunction with conventional Western medicine, in clinical practice around the world to treat breast cancer. The study systematically reviewed and summarized the quality of life of breast cancer patients treated with integrated treatment method vs. conventional Western medicine.METHODS: Eight databases including PubMed, EMBASE, Web of Science, the Cochrane Library, Chinese National Knowledge Infrastructure, China Biology Medicine Disc, Chinese Sc...
Source: Evidence-based Complementary and Alternative Medicine - January 17, 2022 Category: Complementary Medicine Authors: Xue Bai Na Ta Guo-Hua Gong Bin Zhang Cheng-Xi Wei Source Type: research

The Effect of Broccoli Extract in Arsenic-Induced Experimental Poisoning on the Hematological, Biochemical, and Electrophoretic Parameters of the Liver and Kidney of Rats
Evid Based Complement Alternat Med. 2022 Jan 5;2022:3509706. doi: 10.1155/2022/3509706. eCollection 2022.ABSTRACTHeavy metals such as arsenic contribute to environmental pollution that can lead to systemic effects in various body organs. Some medicinal plants such as broccoli have been shown to reduce the harmful effects of these heavy metals. The main aim of the present study is to evaluate the effects of broccoli extract on liver and kidney toxicity, considering hematological and biochemical changes. The experimental study was performed in 28 days on 32 male Wistar rats classified into four groups: the control group (C),...
Source: Evidence-based Complementary and Alternative Medicine - January 17, 2022 Category: Complementary Medicine Authors: Mahdieh Raeeszadeh Pouria Karimi Nadia Khademi Pejman Mortazavi Source Type: research

The Study of Steaming Durations and Temperatures on the Chemical Characterization, Neuroprotective, and Antioxidant Activities of < em > Panax notoginseng < /em >
Evid Based Complement Alternat Med. 2022 Jan 6;2022:3698518. doi: 10.1155/2022/3698518. eCollection 2022.ABSTRACTPanax notoginseng (PN) is one of the most valuable traditional Chinese medicines and has extensive pharmacological effects. Recent studies demonstrated that PN exhibited pharmacological effect related to Alzheimer's disease (AD). However, whether steaming process can boost its anti-AD activity is still unexplored. To fill this gap, effects of steaming durations and temperatures on the chemical characterization, neuroprotective and antioxidant activities of PN were systematically investigated in this study. HPLC ...
Source: Evidence-based Complementary and Alternative Medicine - January 17, 2022 Category: Complementary Medicine Authors: Didi Ma Jue Wang Guo Yin Lijun Wang Yibao Jin Yang Huang Kaishun Bi Yi Lu Tiejie Wang Source Type: research

Systematic Understanding of Mechanism of Danggui Shaoyao San against Ischemic Stroke Using a Network Pharmacology Approach
Evid Based Complement Alternat Med. 2022 Jan 5;2022:3747285. doi: 10.1155/2022/3747285. eCollection 2022.ABSTRACTPURPOSE: Danggui Shaoyao San (DSS) was developed to treat the ischemic stroke (IS) in patients and animal models. The purpose of this study was to explore its active compounds and demonstrate its mechanism against IS through network pharmacology, molecular docking, and animal experiment.METHODS: All the components of DSS were retrieved from the pharmacology database of TCM system. The genes corresponding to the targets were retrieved using OMIM, CTD database, and TTD database. The herb-compound-target network wa...
Source: Evidence-based Complementary and Alternative Medicine - January 17, 2022 Category: Complementary Medicine Authors: Sijie Li Yong Yang Wei Zhang Haiyan Li Wantong Yu Chen Gao Jiali Xu Wenbo Zhao Changhong Ren Source Type: research

RNA Sequencing Analysis of Gene Expression by Electroacupuncture in Guinea Pig Gallstone Models
CONCLUSION: We identified a few GOs and genes that might play key roles in the treatment of gallstone. This study may help understand the therapeutic mechanism of EA for gallstone.PMID:35035504 | PMC:PMC8759925 | DOI:10.1155/2022/3793946 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - January 17, 2022 Category: Complementary Medicine Authors: Mingyao Hao Zhiqiang Dou Luyao Xu Zongchen Shao Hongwei Sun Zhaofeng Li Source Type: research

Efficacy and Safety of "Three Chinese Patent Medicines and Three TCM Prescriptions" for COVID-19: A Systematic Review and Network Meta-Analysis
CONCLUSION: This study was the first most large-scale and comprehensive research of TMTP for COVID-19. The results showed that LHQW had good efficacy without obvious adverse reactions. Therefore, we believe that it should be firstly recommended for COVID-19 treatment. In addition, XBJ is recommended for patients with a severe fever, fatigue, and diarrhea, and JHQG is recommended for patients with obvious rhinobyon and rhinorrhea; then, XFBD is recommended for patients with cough and chest tightness as the main manifestation. Our findings will help experts develop new COVID-19 treatment guidelines to better guide clinical m...
Source: Evidence-based Complementary and Alternative Medicine - January 17, 2022 Category: Complementary Medicine Authors: Shuo Zhang Zhen Yang Zhen-Lin Chen Zhuo-Ning Li Shi-Jun Yue Jia-Jia Li Yu-Ping Tang Source Type: research

(E)-9-Octadecenoic Acid Ethyl Ester Derived from Lotus Seedpod Ameliorates Inflammatory Responses by Regulating MAPKs and NF- < em > κ < /em > B Signalling Pathways in LPS-Induced RAW264.7 Macrophages
In this study, we evaluated the anti-inflammatory activities of ten natural compounds derived from lotus seedpod and discovered (E)-9-octadecenoic acid ethyl ester (E9OAEE) inhibited the production of nitric oxide (NO) optimally in lipopolysaccharide (LPS)-induced RAW264.7 macrophages. Furthermore, we explored the effects of E9OAEE on inflammatory responses and the underlying mechanisms in LPS-induced RAW264.7 macrophages. The results indicated that E9OAEE significantly suppressed the production of NO, prostaglandin E2 (PGE2), and tumour necrosis factor-α (TNFα) in a dose-dependent manner. The protein expressio...
Source: Evidence-based Complementary and Alternative Medicine - January 17, 2022 Category: Complementary Medicine Authors: Chuanqi Xie Shufen Wang Mingyuan Cao Wei Xiong Lei Wu Source Type: research

A Network Meta-Analysis of the Clinical Efficacy and Safety of Commonly Used Chinese Patent Medicines in the Auxiliary Treatment of Poststroke Depression
CONCLUSION: The mechanisms of seven CPMs in the adjuvant treatment of PSD have advantages. In terms of safety and efficacy, the CPMs had better clinical adjuvant treatment performance. Although this study concluded that the Jieyu Anshen capsule is the preferred drug for clinical treatment, a clear conclusion still needs to be verified in a high-quality randomized controlled study. In clinical practice, accurate selection and application can be carried out according to the specific characteristics of patients.PMID:35035507 | PMC:PMC8758270 | DOI:10.1155/2022/7265769 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - January 17, 2022 Category: Complementary Medicine Authors: Ying Yu Gong Zhang Tao Han Hongjie Liu Hailiang Huang Source Type: research

Structure-Based In Silico Investigation of Agonists for Proteins Involved in Breast Cancer
Evid Based Complement Alternat Med. 2022 Jan 6;2022:7278731. doi: 10.1155/2022/7278731. eCollection 2022.ABSTRACTCancer is recognized as one of the main causes of mortality worldwide by the World Health Organization. The high cost of currently available cancer therapy and certain limitations of current treatment make it necessary to search for novel, cost-effective, and efficient methods of cancer treatment. Therefore, in the current investigation, sixty-two compounds from five medicinal plants (Tinospora cordifolia, Ocimum tenuiflorum, Podophyllum hexandrum, Andrographis paniculata, and Beta vulgaris) and two proteins tha...
Source: Evidence-based Complementary and Alternative Medicine - January 17, 2022 Category: Complementary Medicine Authors: Arpita Roy Ashutosh Anand Saksham Garg Mohd Shahnawaz Khan Sidharth Bhasin Muhammad Nadeem Asghar Talha Bin Emran Source Type: research

Pretreatment of Nicorandil Protects the Heart from Exhaustive Exercise-Induced Myocardial Injury in Rats
CONCLUSION: Our result demonstrated that nicorandil has protective effects in EE-induced myocardial injury with dose-dependent effects. A combination of nicorandil and EP can further improve the protective effects. Taken together, nicorandil can be potentially used as an intervention method in EE-induced myocardial injury.PMID:35035509 | PMC:PMC8758261 | DOI:10.1155/2022/7550872 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - January 17, 2022 Category: Complementary Medicine Authors: Lei Lv Lin Li Yiyong Zhu Anwar Azhar Yao Li Yongyuan Wang Tao Jin Xin Yin Xi Chen Yu Liu Yong Zhong Source Type: research

The Clinical Efficacy of Chemotherapy Combined with Traditional Chinese Medicine in the Treatment of Cervical Cancer and Its Influence on Cellular Immunity, Serum CEA, and TNF- < em > α < /em >
CONCLUSION: Chemotherapy combined with traditional Chinese can help improve the clinical efficacy and immunity in patients with cervical cancer. Moreover, the safety and feasibility of the treatment method are relatively high.PMID:35035510 | PMC:PMC8759920 | DOI:10.1155/2022/7728739 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - January 17, 2022 Category: Complementary Medicine Authors: Qiannan Zhao Juanjuan Liu Sai Wang Xiuqin Wang Xiufang Jiang Source Type: research

Yijin-Tang Attenuates Cigarette Smoke and Lipopolysaccharide-Induced Chronic Obstructive Pulmonary Disease in Mice
CONCLUSION: Collectively, our findings show that YJT attenuates respiratory inflammation and airway remodeling caused by CS and LPS exposure; therefore, therapeutic applications in COPD can be considered.PMID:35035511 | PMC:PMC8754600 | DOI:10.1155/2022/7902920 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - January 17, 2022 Category: Complementary Medicine Authors: Jinhyung Rho Chang-Seob Seo Eun-Ju Hong Eun Bok Baek Eunhye Jung Suyoung Park Mee-Young Lee Hyo-Jung Kwun Source Type: research

Effects of Shen-Yuan-Dan on Periprocedural Myocardial Injury and the Number of Peripheral Blood Endothelial Progenitor Cells in Patients with Unstable Angina Pectoris Undergoing Elective Percutaneous Coronary Intervention
CONCLUSION: SYD can reduce PMI and promote the mobilization of EPCs in the perioperative period of elective PCI in patients with UA.PMID:35035512 | PMC:PMC8759927 | DOI:10.1155/2022/9055585 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - January 17, 2022 Category: Complementary Medicine Authors: Zhenmin Zhang Wenlong Xing Hongxu Liu Qi Zhou Xinyi Liu Juju Shang Source Type: research

Corrigendum to "Exploring the Pharmacological Mechanism of Liuwei Dihuang Decoction for Diabetic Retinopathy: A Systematic Biological Strategy-Based Research"
Evid Based Complement Alternat Med. 2022 Jan 5;2022:9790813. doi: 10.1155/2022/9790813. eCollection 2022.ABSTRACT[This corrects the article DOI: 10.1155/2021/5544518.].PMID:35035513 | PMC:PMC8754589 | DOI:10.1155/2022/9790813 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - January 17, 2022 Category: Complementary Medicine Authors: Mengxia Yuan Qi He Zhiyong Long Xiaofei Zhu Wang Xiang Yonghe Wu Shibin Lin Source Type: research

Lanzhang Granules Ameliorate Nonalcoholic Fatty Liver Disease by Regulating the PPAR < em > α < /em > Signaling Pathway
CONCLUSION: LZG can improve NAFLD in mice or cell models. A major underlying mechanism may be the regulation of the PPARα signaling pathway to improve lipid metabolism and inhibit the inflammatory response. This study will help to promote the clinical application of LZG for the treatment of NAFLD.PMID:35035496 | PMC:PMC8759917 | DOI:10.1155/2022/1124901 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - January 17, 2022 Category: Complementary Medicine Authors: Ping Huang Lili Yang Yang Liu Yuwei Jiang Yiping Li Zhiwei Chen Haiyan Song Peiyong Zheng Source Type: research

Overview of Microvascular Angina Pectoris and Discussion of Traditional Chinese Medicine Intervention
Evid Based Complement Alternat Med. 2022 Jan 5;2022:1497722. doi: 10.1155/2022/1497722. eCollection 2022.ABSTRACTPrevious research and treatment of coronary heart disease mostly focused on the large epicardial vessels, with limited research on the small endocardial coronary arteries or arterioles that could not be detected by coronary angiography, especially microvascular angina caused by microvascular stenosis or microcirculation dysfunction. Conventional Western medicine therapies have no specific efficacy, but traditional Chinese medicine has significant advantages in this regard. In particular, traditional Chinese medi...
Source: Evidence-based Complementary and Alternative Medicine - January 17, 2022 Category: Complementary Medicine Authors: Linghua Yu Xiaoyan Lu Chenxi Xu Tong Li Yanling Wang Anxiang Liu Yubi Wang Li Chen Huangyu Xu Source Type: research

Pharmacological Mechanisms of Tinglizi against Chronic Heart Failure Determined by Network Pharmacology and Molecular Docking
Evid Based Complement Alternat Med. 2022 Jan 6;2022:2152399. doi: 10.1155/2022/2152399. eCollection 2022.ABSTRACTOBJECTIVE: Tinglizi has been extensively used to treat chronic heart failure (CHF) in modern times, but the material basis and pharmacological mechanisms are still unclear. To explore the material basis and corresponding potential targets and to elucidate the mechanism of Tinglizi, network pharmacology and molecular docking methods were utilized.METHODS: The main chemical compounds and potential targets of Tinglizi were collected from the pharmacological database analysis platform (TCMSP). The corresponding gene...
Source: Evidence-based Complementary and Alternative Medicine - January 17, 2022 Category: Complementary Medicine Authors: Liangtao Luo Haowen Wang Guowei Huang Lu Zhang Xiuwei Li Chongyang Ma Xing Wang Source Type: research

A Study of the Protective Effect of Bushen Huoxue Prescription on Cerebral Microvascular Endothelia Based on Proteomics and Bioinformatics
Evid Based Complement Alternat Med. 2022 Jan 6;2022:2545074. doi: 10.1155/2022/2545074. eCollection 2022.ABSTRACTDiabetic cognitive dysfunction is a serious complication of type 2 diabetes mellitus (T2DM), which can cause neurological and microvascular damage in the brain. At present, there is no effective treatment for this complication. Bushen Huoxue prescription (BSHX) is a newly formulated compound Chinese medicine containing 7 components. Previous research indicated that BSHX was neuroprotective against advanced glycosylation end product (AGE)-induced PC12 cell insult; however, the effect of BSHX on AGE-induced cerebr...
Source: Evidence-based Complementary and Alternative Medicine - January 17, 2022 Category: Complementary Medicine Authors: Shao-Yang Zhao Huan-Huan Zhao Yi-Ming Li Bao-Hua Wang Sai-Mei Li Source Type: research

Effects of Integrated Chinese Traditional Medicine and Conventional Western Medicine on the Quality of Life of Breast Cancer Patients: A Systematic Review and Meta-Analysis
Evid Based Complement Alternat Med. 2022 Jan 7;2022:3123878. doi: 10.1155/2022/3123878. eCollection 2022.ABSTRACTBACKGROUND: Traditional Chinese medicine has been widely used, in conjunction with conventional Western medicine, in clinical practice around the world to treat breast cancer. The study systematically reviewed and summarized the quality of life of breast cancer patients treated with integrated treatment method vs. conventional Western medicine.METHODS: Eight databases including PubMed, EMBASE, Web of Science, the Cochrane Library, Chinese National Knowledge Infrastructure, China Biology Medicine Disc, Chinese Sc...
Source: Evidence-based Complementary and Alternative Medicine - January 17, 2022 Category: Complementary Medicine Authors: Xue Bai Na Ta Guo-Hua Gong Bin Zhang Cheng-Xi Wei Source Type: research

The Effect of Broccoli Extract in Arsenic-Induced Experimental Poisoning on the Hematological, Biochemical, and Electrophoretic Parameters of the Liver and Kidney of Rats
Evid Based Complement Alternat Med. 2022 Jan 5;2022:3509706. doi: 10.1155/2022/3509706. eCollection 2022.ABSTRACTHeavy metals such as arsenic contribute to environmental pollution that can lead to systemic effects in various body organs. Some medicinal plants such as broccoli have been shown to reduce the harmful effects of these heavy metals. The main aim of the present study is to evaluate the effects of broccoli extract on liver and kidney toxicity, considering hematological and biochemical changes. The experimental study was performed in 28 days on 32 male Wistar rats classified into four groups: the control group (C),...
Source: Evidence-based Complementary and Alternative Medicine - January 17, 2022 Category: Complementary Medicine Authors: Mahdieh Raeeszadeh Pouria Karimi Nadia Khademi Pejman Mortazavi Source Type: research

The Study of Steaming Durations and Temperatures on the Chemical Characterization, Neuroprotective, and Antioxidant Activities of < em > Panax notoginseng < /em >
Evid Based Complement Alternat Med. 2022 Jan 6;2022:3698518. doi: 10.1155/2022/3698518. eCollection 2022.ABSTRACTPanax notoginseng (PN) is one of the most valuable traditional Chinese medicines and has extensive pharmacological effects. Recent studies demonstrated that PN exhibited pharmacological effect related to Alzheimer's disease (AD). However, whether steaming process can boost its anti-AD activity is still unexplored. To fill this gap, effects of steaming durations and temperatures on the chemical characterization, neuroprotective and antioxidant activities of PN were systematically investigated in this study. HPLC ...
Source: Evidence-based Complementary and Alternative Medicine - January 17, 2022 Category: Complementary Medicine Authors: Didi Ma Jue Wang Guo Yin Lijun Wang Yibao Jin Yang Huang Kaishun Bi Yi Lu Tiejie Wang Source Type: research

Systematic Understanding of Mechanism of Danggui Shaoyao San against Ischemic Stroke Using a Network Pharmacology Approach
Evid Based Complement Alternat Med. 2022 Jan 5;2022:3747285. doi: 10.1155/2022/3747285. eCollection 2022.ABSTRACTPURPOSE: Danggui Shaoyao San (DSS) was developed to treat the ischemic stroke (IS) in patients and animal models. The purpose of this study was to explore its active compounds and demonstrate its mechanism against IS through network pharmacology, molecular docking, and animal experiment.METHODS: All the components of DSS were retrieved from the pharmacology database of TCM system. The genes corresponding to the targets were retrieved using OMIM, CTD database, and TTD database. The herb-compound-target network wa...
Source: Evidence-based Complementary and Alternative Medicine - January 17, 2022 Category: Complementary Medicine Authors: Sijie Li Yong Yang Wei Zhang Haiyan Li Wantong Yu Chen Gao Jiali Xu Wenbo Zhao Changhong Ren Source Type: research

RNA Sequencing Analysis of Gene Expression by Electroacupuncture in Guinea Pig Gallstone Models
CONCLUSION: We identified a few GOs and genes that might play key roles in the treatment of gallstone. This study may help understand the therapeutic mechanism of EA for gallstone.PMID:35035504 | PMC:PMC8759925 | DOI:10.1155/2022/3793946 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - January 17, 2022 Category: Complementary Medicine Authors: Mingyao Hao Zhiqiang Dou Luyao Xu Zongchen Shao Hongwei Sun Zhaofeng Li Source Type: research

Efficacy and Safety of "Three Chinese Patent Medicines and Three TCM Prescriptions" for COVID-19: A Systematic Review and Network Meta-Analysis
CONCLUSION: This study was the first most large-scale and comprehensive research of TMTP for COVID-19. The results showed that LHQW had good efficacy without obvious adverse reactions. Therefore, we believe that it should be firstly recommended for COVID-19 treatment. In addition, XBJ is recommended for patients with a severe fever, fatigue, and diarrhea, and JHQG is recommended for patients with obvious rhinobyon and rhinorrhea; then, XFBD is recommended for patients with cough and chest tightness as the main manifestation. Our findings will help experts develop new COVID-19 treatment guidelines to better guide clinical m...
Source: Evidence-based Complementary and Alternative Medicine - January 17, 2022 Category: Complementary Medicine Authors: Shuo Zhang Zhen Yang Zhen-Lin Chen Zhuo-Ning Li Shi-Jun Yue Jia-Jia Li Yu-Ping Tang Source Type: research

(E)-9-Octadecenoic Acid Ethyl Ester Derived from Lotus Seedpod Ameliorates Inflammatory Responses by Regulating MAPKs and NF- < em > κ < /em > B Signalling Pathways in LPS-Induced RAW264.7 Macrophages
In this study, we evaluated the anti-inflammatory activities of ten natural compounds derived from lotus seedpod and discovered (E)-9-octadecenoic acid ethyl ester (E9OAEE) inhibited the production of nitric oxide (NO) optimally in lipopolysaccharide (LPS)-induced RAW264.7 macrophages. Furthermore, we explored the effects of E9OAEE on inflammatory responses and the underlying mechanisms in LPS-induced RAW264.7 macrophages. The results indicated that E9OAEE significantly suppressed the production of NO, prostaglandin E2 (PGE2), and tumour necrosis factor-α (TNFα) in a dose-dependent manner. The protein expressio...
Source: Evidence-based Complementary and Alternative Medicine - January 17, 2022 Category: Complementary Medicine Authors: Chuanqi Xie Shufen Wang Mingyuan Cao Wei Xiong Lei Wu Source Type: research

A Network Meta-Analysis of the Clinical Efficacy and Safety of Commonly Used Chinese Patent Medicines in the Auxiliary Treatment of Poststroke Depression
CONCLUSION: The mechanisms of seven CPMs in the adjuvant treatment of PSD have advantages. In terms of safety and efficacy, the CPMs had better clinical adjuvant treatment performance. Although this study concluded that the Jieyu Anshen capsule is the preferred drug for clinical treatment, a clear conclusion still needs to be verified in a high-quality randomized controlled study. In clinical practice, accurate selection and application can be carried out according to the specific characteristics of patients.PMID:35035507 | PMC:PMC8758270 | DOI:10.1155/2022/7265769 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - January 17, 2022 Category: Complementary Medicine Authors: Ying Yu Gong Zhang Tao Han Hongjie Liu Hailiang Huang Source Type: research

Structure-Based In Silico Investigation of Agonists for Proteins Involved in Breast Cancer
Evid Based Complement Alternat Med. 2022 Jan 6;2022:7278731. doi: 10.1155/2022/7278731. eCollection 2022.ABSTRACTCancer is recognized as one of the main causes of mortality worldwide by the World Health Organization. The high cost of currently available cancer therapy and certain limitations of current treatment make it necessary to search for novel, cost-effective, and efficient methods of cancer treatment. Therefore, in the current investigation, sixty-two compounds from five medicinal plants (Tinospora cordifolia, Ocimum tenuiflorum, Podophyllum hexandrum, Andrographis paniculata, and Beta vulgaris) and two proteins tha...
Source: Evidence-based Complementary and Alternative Medicine - January 17, 2022 Category: Complementary Medicine Authors: Arpita Roy Ashutosh Anand Saksham Garg Mohd Shahnawaz Khan Sidharth Bhasin Muhammad Nadeem Asghar Talha Bin Emran Source Type: research

Pretreatment of Nicorandil Protects the Heart from Exhaustive Exercise-Induced Myocardial Injury in Rats
CONCLUSION: Our result demonstrated that nicorandil has protective effects in EE-induced myocardial injury with dose-dependent effects. A combination of nicorandil and EP can further improve the protective effects. Taken together, nicorandil can be potentially used as an intervention method in EE-induced myocardial injury.PMID:35035509 | PMC:PMC8758261 | DOI:10.1155/2022/7550872 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - January 17, 2022 Category: Complementary Medicine Authors: Lei Lv Lin Li Yiyong Zhu Anwar Azhar Yao Li Yongyuan Wang Tao Jin Xin Yin Xi Chen Yu Liu Yong Zhong Source Type: research

The Clinical Efficacy of Chemotherapy Combined with Traditional Chinese Medicine in the Treatment of Cervical Cancer and Its Influence on Cellular Immunity, Serum CEA, and TNF- < em > α < /em >
CONCLUSION: Chemotherapy combined with traditional Chinese can help improve the clinical efficacy and immunity in patients with cervical cancer. Moreover, the safety and feasibility of the treatment method are relatively high.PMID:35035510 | PMC:PMC8759920 | DOI:10.1155/2022/7728739 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - January 17, 2022 Category: Complementary Medicine Authors: Qiannan Zhao Juanjuan Liu Sai Wang Xiuqin Wang Xiufang Jiang Source Type: research

Yijin-Tang Attenuates Cigarette Smoke and Lipopolysaccharide-Induced Chronic Obstructive Pulmonary Disease in Mice
CONCLUSION: Collectively, our findings show that YJT attenuates respiratory inflammation and airway remodeling caused by CS and LPS exposure; therefore, therapeutic applications in COPD can be considered.PMID:35035511 | PMC:PMC8754600 | DOI:10.1155/2022/7902920 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - January 17, 2022 Category: Complementary Medicine Authors: Jinhyung Rho Chang-Seob Seo Eun-Ju Hong Eun Bok Baek Eunhye Jung Suyoung Park Mee-Young Lee Hyo-Jung Kwun Source Type: research

Effects of Shen-Yuan-Dan on Periprocedural Myocardial Injury and the Number of Peripheral Blood Endothelial Progenitor Cells in Patients with Unstable Angina Pectoris Undergoing Elective Percutaneous Coronary Intervention
CONCLUSION: SYD can reduce PMI and promote the mobilization of EPCs in the perioperative period of elective PCI in patients with UA.PMID:35035512 | PMC:PMC8759927 | DOI:10.1155/2022/9055585 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - January 17, 2022 Category: Complementary Medicine Authors: Zhenmin Zhang Wenlong Xing Hongxu Liu Qi Zhou Xinyi Liu Juju Shang Source Type: research

Corrigendum to "Exploring the Pharmacological Mechanism of Liuwei Dihuang Decoction for Diabetic Retinopathy: A Systematic Biological Strategy-Based Research"
Evid Based Complement Alternat Med. 2022 Jan 5;2022:9790813. doi: 10.1155/2022/9790813. eCollection 2022.ABSTRACT[This corrects the article DOI: 10.1155/2021/5544518.].PMID:35035513 | PMC:PMC8754589 | DOI:10.1155/2022/9790813 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - January 17, 2022 Category: Complementary Medicine Authors: Mengxia Yuan Qi He Zhiyong Long Xiaofei Zhu Wang Xiang Yonghe Wu Shibin Lin Source Type: research

Lanzhang Granules Ameliorate Nonalcoholic Fatty Liver Disease by Regulating the PPAR < em > α < /em > Signaling Pathway
CONCLUSION: LZG can improve NAFLD in mice or cell models. A major underlying mechanism may be the regulation of the PPARα signaling pathway to improve lipid metabolism and inhibit the inflammatory response. This study will help to promote the clinical application of LZG for the treatment of NAFLD.PMID:35035496 | PMC:PMC8759917 | DOI:10.1155/2022/1124901 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - January 17, 2022 Category: Complementary Medicine Authors: Ping Huang Lili Yang Yang Liu Yuwei Jiang Yiping Li Zhiwei Chen Haiyan Song Peiyong Zheng Source Type: research

Overview of Microvascular Angina Pectoris and Discussion of Traditional Chinese Medicine Intervention
Evid Based Complement Alternat Med. 2022 Jan 5;2022:1497722. doi: 10.1155/2022/1497722. eCollection 2022.ABSTRACTPrevious research and treatment of coronary heart disease mostly focused on the large epicardial vessels, with limited research on the small endocardial coronary arteries or arterioles that could not be detected by coronary angiography, especially microvascular angina caused by microvascular stenosis or microcirculation dysfunction. Conventional Western medicine therapies have no specific efficacy, but traditional Chinese medicine has significant advantages in this regard. In particular, traditional Chinese medi...
Source: Evidence-based Complementary and Alternative Medicine - January 17, 2022 Category: Complementary Medicine Authors: Linghua Yu Xiaoyan Lu Chenxi Xu Tong Li Yanling Wang Anxiang Liu Yubi Wang Li Chen Huangyu Xu Source Type: research

Pharmacological Mechanisms of Tinglizi against Chronic Heart Failure Determined by Network Pharmacology and Molecular Docking
Evid Based Complement Alternat Med. 2022 Jan 6;2022:2152399. doi: 10.1155/2022/2152399. eCollection 2022.ABSTRACTOBJECTIVE: Tinglizi has been extensively used to treat chronic heart failure (CHF) in modern times, but the material basis and pharmacological mechanisms are still unclear. To explore the material basis and corresponding potential targets and to elucidate the mechanism of Tinglizi, network pharmacology and molecular docking methods were utilized.METHODS: The main chemical compounds and potential targets of Tinglizi were collected from the pharmacological database analysis platform (TCMSP). The corresponding gene...
Source: Evidence-based Complementary and Alternative Medicine - January 17, 2022 Category: Complementary Medicine Authors: Liangtao Luo Haowen Wang Guowei Huang Lu Zhang Xiuwei Li Chongyang Ma Xing Wang Source Type: research

A Study of the Protective Effect of Bushen Huoxue Prescription on Cerebral Microvascular Endothelia Based on Proteomics and Bioinformatics
Evid Based Complement Alternat Med. 2022 Jan 6;2022:2545074. doi: 10.1155/2022/2545074. eCollection 2022.ABSTRACTDiabetic cognitive dysfunction is a serious complication of type 2 diabetes mellitus (T2DM), which can cause neurological and microvascular damage in the brain. At present, there is no effective treatment for this complication. Bushen Huoxue prescription (BSHX) is a newly formulated compound Chinese medicine containing 7 components. Previous research indicated that BSHX was neuroprotective against advanced glycosylation end product (AGE)-induced PC12 cell insult; however, the effect of BSHX on AGE-induced cerebr...
Source: Evidence-based Complementary and Alternative Medicine - January 17, 2022 Category: Complementary Medicine Authors: Shao-Yang Zhao Huan-Huan Zhao Yi-Ming Li Bao-Hua Wang Sai-Mei Li Source Type: research