Antihypertensive Effects of the Methanol Extract and the Ethyl Acetate Fraction from < em > Crinum zeylanicum < /em > (Amaryllidaceae) Leaves in L-NAME-Treated Rat
This study aimed to investigate the antihypertensive effect of C. zeylanicum extract in N ω -nitro-L-arginine methyl ester- (L-NAME-) induced hypertensive rats. The aqueous extract of C. zeylanicum (LAE) was obtained by lyophilizing the juice of triturated fresh leaves. The methanol extract (LME) prepared by maceration of the dried leaves was further partitioned to chloroform (LCF), ethyl acetate (LEAF), and residual (LRF) fractions. The total polyphenol, flavonoid content, and antiradical potentials of these extracts were determined. The curative antihypertensive and renal function protective effects of LME and LEAF...
Source: Evidence-based Complementary and Alternative Medicine - July 21, 2021 Category: Complementary Medicine Authors: Magloire Kanyou Ndjenda Ii Elvine Pami Nguelefack-Mbuyo Albert Donatien Atsamo Christian Kuete Fofie Chamberlin Fodem Filomain Nguemo Telesphore Benoit Nguelefack Source Type: research

To Explore the Mechanism and Equivalent Molecular Group of Radix Astragali and Semen Lepidii in Treating Heart Failure Based on Network Pharmacology
In this study, we explored the mechanism of action of HQ-TLZ in the treatment of heart failure based on network pharmacology. We obtained 11 active ingredients and 109 targets from the TCMSP database and SwissTargetPrediction database. Next, we constructed the action network and carried out enrichment analysis. The results showed that HQ-TLZ treatment of heart failure is primarily achieved by regulating the insulin resistance, erbB signaling pathway, PI3K-Akt signaling pathway, and VEGF signaling pathway. After inverse targeting, molecular docking, and literature search, we determined that the equivalent molecular groups o...
Source: Evidence-based Complementary and Alternative Medicine - July 21, 2021 Category: Complementary Medicine Authors: Yi-Ding Yu Yi-Ping Xiu Yang-Fan Li Juan Zhang Yi-Tao Xue Yan Li Source Type: research

The Effects of < em > Berberis integerrima < /em > Fruit Extract on Glycemic Control Parameters in Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Clinical Trial
CONCLUSION: Consumption of B. integerrima Bunge fruit extract at a dosage of 1000 mg daily decreases FBS and HbA1c but does not affect HOMA-IR in patients with type 2 diabetes mellitus.PMID:34285701 | PMC:PMC8275404 | DOI:10.1155/2021/5583691 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - July 21, 2021 Category: Complementary Medicine Authors: Rasool Soltani Syed Mustafa Ghanadian Bijan Iraj Alireza Homayouni Tanin Shahmiveh Esfahani Mojtaba Akbari Source Type: research

Transcriptomic Analysis Exploring the Molecular Mechanisms of Hanchuan Zupa Granules in Alleviating Asthma in Rat
Conclusion. HCZP could alleviate asthma via regulating the expression of several hub genes, which might serve as therapeutic targets for asthma. However, the mechanism of these genes will be studied in the future.PMID:34285702 | PMC:PMC8275397 | DOI:10.1155/2021/5584099 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - July 21, 2021 Category: Complementary Medicine Authors: Hailong Yin Yanbo Fan Dandan Mu Fei Song Fang Tian Qiang Yin Source Type: research

A Review on Antidiabetic Activity of < em > Centaurea < /em > spp.: A New Approach for Developing Herbal Remedies
CONCLUSION: Potent results encouraged us to review their efficacy to open a new horizon for development of herbal antidiabetic agents.PMID:34285703 | PMC:PMC8275385 | DOI:10.1155/2021/5587938 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - July 21, 2021 Category: Complementary Medicine Authors: Samaneh Fattaheian-Dehkordi Reza Hojjatifard Mina Saeedi Mahnaz Khanavi Source Type: research

Desmin Correlated with Cx43 May Facilitate Intercellular Electrical Coupling during Chronic Heart Failure
In this study, we measured desmin expression using western blotting and qPCR in the failed hearts of human patients and rats. Our results showed that desmin content was reduced at the protein level in failed hearts and isolated cardiomyocytes. The association of desmin and the gap junction proteins connexin 43 (Cx43) and zonula occludens-1 (ZO-1) was also investigated. Immunoprecipitation assay showed that desmin was associated with Cx43 in cardiomyocytes. To compare the electrical integration of skeletal myoblasts in cocultures with cardiac myocytes, familial amyloid polyneuropathy (FAP) activation rate was found in 33% d...
Source: Evidence-based Complementary and Alternative Medicine - July 21, 2021 Category: Complementary Medicine Authors: Junxian Cao Qianping Gao Hongyan Chen Can Wang Qiuju Zhang Zhipeng Wang Yuanshi Li Source Type: research

A Review on the Mechanism of Tuina Promoting the Recovery of Peripheral Nerve Injury
Evid Based Complement Alternat Med. 2021 Jul 1;2021:6652099. doi: 10.1155/2021/6652099. eCollection 2021.ABSTRACTTuina, as one of the characteristic external therapies of Traditional Chinese Medicine (TCM), has been used to treat the disease caused by peripheral nerve injury (PNI) for thousands of years. An increasing number of clinical trials and animal experiments have demonstrated that tuina can improve the symptoms and promote the recovery of damaged nerves. This review focuses on the mechanistic studies of tuina in promoting the recovery of PNI, which might provide a neurobiological foundation for the effects of tuina...
Source: Evidence-based Complementary and Alternative Medicine - July 21, 2021 Category: Complementary Medicine Authors: Zhifeng Liu Hourong Wang Tianyuan Yu Yi Jiao Yingqi Zhang Di Liu Yajing Xu Qian Guan Mengqian Lu Source Type: research

A Meta-Analysis: Intervention Effect of Mind-Body Exercise on Relieving Cancer-Related Fatigue in Breast Cancer Patients
Evid Based Complement Alternat Med. 2021 Jul 3;2021:9980940. doi: 10.1155/2021/9980940. eCollection 2021.ABSTRACTOBJECTIVE: This paper aims to systematically evaluate the intervention effect of mind-body exercise on cancer-related fatigue in breast cancer patients.METHODS: Databases including PubMed, the Cochrane Library, Embase, Web of Science, CNKI, Wanfang Data, and SINOMED were retrieved to collect randomized controlled trials on the effects of mind-body exercise on relieving cancer-related fatigue in breast cancer patients. The retrieval period started from the founding date of each database to January 6, 2021. Cochra...
Source: Evidence-based Complementary and Alternative Medicine - July 21, 2021 Category: Complementary Medicine Authors: Cong Liu Man Qin Xinhu Zheng Rao Chen Jianghua Zhu Source Type: research

Antihypertensive Effects of the Methanol Extract and the Ethyl Acetate Fraction from < em > Crinum zeylanicum < /em > (Amaryllidaceae) Leaves in L-NAME-Treated Rat
This study aimed to investigate the antihypertensive effect of C. zeylanicum extract in N ω -nitro-L-arginine methyl ester- (L-NAME-) induced hypertensive rats. The aqueous extract of C. zeylanicum (LAE) was obtained by lyophilizing the juice of triturated fresh leaves. The methanol extract (LME) prepared by maceration of the dried leaves was further partitioned to chloroform (LCF), ethyl acetate (LEAF), and residual (LRF) fractions. The total polyphenol, flavonoid content, and antiradical potentials of these extracts were determined. The curative antihypertensive and renal function protective effects of LME and LEAF...
Source: Evidence-based Complementary and Alternative Medicine - July 21, 2021 Category: Complementary Medicine Authors: Magloire Kanyou Ndjenda Ii Elvine Pami Nguelefack-Mbuyo Albert Donatien Atsamo Christian Kuete Fofie Chamberlin Fodem Filomain Nguemo Telesphore Benoit Nguelefack Source Type: research

To Explore the Mechanism and Equivalent Molecular Group of Radix Astragali and Semen Lepidii in Treating Heart Failure Based on Network Pharmacology
In this study, we explored the mechanism of action of HQ-TLZ in the treatment of heart failure based on network pharmacology. We obtained 11 active ingredients and 109 targets from the TCMSP database and SwissTargetPrediction database. Next, we constructed the action network and carried out enrichment analysis. The results showed that HQ-TLZ treatment of heart failure is primarily achieved by regulating the insulin resistance, erbB signaling pathway, PI3K-Akt signaling pathway, and VEGF signaling pathway. After inverse targeting, molecular docking, and literature search, we determined that the equivalent molecular groups o...
Source: Evidence-based Complementary and Alternative Medicine - July 21, 2021 Category: Complementary Medicine Authors: Yi-Ding Yu Yi-Ping Xiu Yang-Fan Li Juan Zhang Yi-Tao Xue Yan Li Source Type: research

The Effects of < em > Berberis integerrima < /em > Fruit Extract on Glycemic Control Parameters in Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Clinical Trial
CONCLUSION: Consumption of B. integerrima Bunge fruit extract at a dosage of 1000 mg daily decreases FBS and HbA1c but does not affect HOMA-IR in patients with type 2 diabetes mellitus.PMID:34285701 | PMC:PMC8275404 | DOI:10.1155/2021/5583691 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - July 21, 2021 Category: Complementary Medicine Authors: Rasool Soltani Syed Mustafa Ghanadian Bijan Iraj Alireza Homayouni Tanin Shahmiveh Esfahani Mojtaba Akbari Source Type: research

Transcriptomic Analysis Exploring the Molecular Mechanisms of Hanchuan Zupa Granules in Alleviating Asthma in Rat
Conclusion. HCZP could alleviate asthma via regulating the expression of several hub genes, which might serve as therapeutic targets for asthma. However, the mechanism of these genes will be studied in the future.PMID:34285702 | PMC:PMC8275397 | DOI:10.1155/2021/5584099 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - July 21, 2021 Category: Complementary Medicine Authors: Hailong Yin Yanbo Fan Dandan Mu Fei Song Fang Tian Qiang Yin Source Type: research

A Review on Antidiabetic Activity of < em > Centaurea < /em > spp.: A New Approach for Developing Herbal Remedies
CONCLUSION: Potent results encouraged us to review their efficacy to open a new horizon for development of herbal antidiabetic agents.PMID:34285703 | PMC:PMC8275385 | DOI:10.1155/2021/5587938 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - July 21, 2021 Category: Complementary Medicine Authors: Samaneh Fattaheian-Dehkordi Reza Hojjatifard Mina Saeedi Mahnaz Khanavi Source Type: research

Desmin Correlated with Cx43 May Facilitate Intercellular Electrical Coupling during Chronic Heart Failure
In this study, we measured desmin expression using western blotting and qPCR in the failed hearts of human patients and rats. Our results showed that desmin content was reduced at the protein level in failed hearts and isolated cardiomyocytes. The association of desmin and the gap junction proteins connexin 43 (Cx43) and zonula occludens-1 (ZO-1) was also investigated. Immunoprecipitation assay showed that desmin was associated with Cx43 in cardiomyocytes. To compare the electrical integration of skeletal myoblasts in cocultures with cardiac myocytes, familial amyloid polyneuropathy (FAP) activation rate was found in 33% d...
Source: Evidence-based Complementary and Alternative Medicine - July 21, 2021 Category: Complementary Medicine Authors: Junxian Cao Qianping Gao Hongyan Chen Can Wang Qiuju Zhang Zhipeng Wang Yuanshi Li Source Type: research

A Review on the Mechanism of Tuina Promoting the Recovery of Peripheral Nerve Injury
Evid Based Complement Alternat Med. 2021 Jul 1;2021:6652099. doi: 10.1155/2021/6652099. eCollection 2021.ABSTRACTTuina, as one of the characteristic external therapies of Traditional Chinese Medicine (TCM), has been used to treat the disease caused by peripheral nerve injury (PNI) for thousands of years. An increasing number of clinical trials and animal experiments have demonstrated that tuina can improve the symptoms and promote the recovery of damaged nerves. This review focuses on the mechanistic studies of tuina in promoting the recovery of PNI, which might provide a neurobiological foundation for the effects of tuina...
Source: Evidence-based Complementary and Alternative Medicine - July 21, 2021 Category: Complementary Medicine Authors: Zhifeng Liu Hourong Wang Tianyuan Yu Yi Jiao Yingqi Zhang Di Liu Yajing Xu Qian Guan Mengqian Lu Source Type: research

A Meta-Analysis: Intervention Effect of Mind-Body Exercise on Relieving Cancer-Related Fatigue in Breast Cancer Patients
Evid Based Complement Alternat Med. 2021 Jul 3;2021:9980940. doi: 10.1155/2021/9980940. eCollection 2021.ABSTRACTOBJECTIVE: This paper aims to systematically evaluate the intervention effect of mind-body exercise on cancer-related fatigue in breast cancer patients.METHODS: Databases including PubMed, the Cochrane Library, Embase, Web of Science, CNKI, Wanfang Data, and SINOMED were retrieved to collect randomized controlled trials on the effects of mind-body exercise on relieving cancer-related fatigue in breast cancer patients. The retrieval period started from the founding date of each database to January 6, 2021. Cochra...
Source: Evidence-based Complementary and Alternative Medicine - July 21, 2021 Category: Complementary Medicine Authors: Cong Liu Man Qin Xinhu Zheng Rao Chen Jianghua Zhu Source Type: research

Antihypertensive Effects of the Methanol Extract and the Ethyl Acetate Fraction from < em > Crinum zeylanicum < /em > (Amaryllidaceae) Leaves in L-NAME-Treated Rat
This study aimed to investigate the antihypertensive effect of C. zeylanicum extract in N ω -nitro-L-arginine methyl ester- (L-NAME-) induced hypertensive rats. The aqueous extract of C. zeylanicum (LAE) was obtained by lyophilizing the juice of triturated fresh leaves. The methanol extract (LME) prepared by maceration of the dried leaves was further partitioned to chloroform (LCF), ethyl acetate (LEAF), and residual (LRF) fractions. The total polyphenol, flavonoid content, and antiradical potentials of these extracts were determined. The curative antihypertensive and renal function protective effects of LME and LEAF...
Source: Evidence-based Complementary and Alternative Medicine - July 21, 2021 Category: Complementary Medicine Authors: Magloire Kanyou Ndjenda Ii Elvine Pami Nguelefack-Mbuyo Albert Donatien Atsamo Christian Kuete Fofie Chamberlin Fodem Filomain Nguemo Telesphore Benoit Nguelefack Source Type: research

To Explore the Mechanism and Equivalent Molecular Group of Radix Astragali and Semen Lepidii in Treating Heart Failure Based on Network Pharmacology
In this study, we explored the mechanism of action of HQ-TLZ in the treatment of heart failure based on network pharmacology. We obtained 11 active ingredients and 109 targets from the TCMSP database and SwissTargetPrediction database. Next, we constructed the action network and carried out enrichment analysis. The results showed that HQ-TLZ treatment of heart failure is primarily achieved by regulating the insulin resistance, erbB signaling pathway, PI3K-Akt signaling pathway, and VEGF signaling pathway. After inverse targeting, molecular docking, and literature search, we determined that the equivalent molecular groups o...
Source: Evidence-based Complementary and Alternative Medicine - July 21, 2021 Category: Complementary Medicine Authors: Yi-Ding Yu Yi-Ping Xiu Yang-Fan Li Juan Zhang Yi-Tao Xue Yan Li Source Type: research

The Effects of < em > Berberis integerrima < /em > Fruit Extract on Glycemic Control Parameters in Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Clinical Trial
CONCLUSION: Consumption of B. integerrima Bunge fruit extract at a dosage of 1000 mg daily decreases FBS and HbA1c but does not affect HOMA-IR in patients with type 2 diabetes mellitus.PMID:34285701 | PMC:PMC8275404 | DOI:10.1155/2021/5583691 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - July 21, 2021 Category: Complementary Medicine Authors: Rasool Soltani Syed Mustafa Ghanadian Bijan Iraj Alireza Homayouni Tanin Shahmiveh Esfahani Mojtaba Akbari Source Type: research

Transcriptomic Analysis Exploring the Molecular Mechanisms of Hanchuan Zupa Granules in Alleviating Asthma in Rat
Conclusion. HCZP could alleviate asthma via regulating the expression of several hub genes, which might serve as therapeutic targets for asthma. However, the mechanism of these genes will be studied in the future.PMID:34285702 | PMC:PMC8275397 | DOI:10.1155/2021/5584099 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - July 21, 2021 Category: Complementary Medicine Authors: Hailong Yin Yanbo Fan Dandan Mu Fei Song Fang Tian Qiang Yin Source Type: research

A Review on Antidiabetic Activity of < em > Centaurea < /em > spp.: A New Approach for Developing Herbal Remedies
CONCLUSION: Potent results encouraged us to review their efficacy to open a new horizon for development of herbal antidiabetic agents.PMID:34285703 | PMC:PMC8275385 | DOI:10.1155/2021/5587938 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - July 21, 2021 Category: Complementary Medicine Authors: Samaneh Fattaheian-Dehkordi Reza Hojjatifard Mina Saeedi Mahnaz Khanavi Source Type: research

Desmin Correlated with Cx43 May Facilitate Intercellular Electrical Coupling during Chronic Heart Failure
In this study, we measured desmin expression using western blotting and qPCR in the failed hearts of human patients and rats. Our results showed that desmin content was reduced at the protein level in failed hearts and isolated cardiomyocytes. The association of desmin and the gap junction proteins connexin 43 (Cx43) and zonula occludens-1 (ZO-1) was also investigated. Immunoprecipitation assay showed that desmin was associated with Cx43 in cardiomyocytes. To compare the electrical integration of skeletal myoblasts in cocultures with cardiac myocytes, familial amyloid polyneuropathy (FAP) activation rate was found in 33% d...
Source: Evidence-based Complementary and Alternative Medicine - July 21, 2021 Category: Complementary Medicine Authors: Junxian Cao Qianping Gao Hongyan Chen Can Wang Qiuju Zhang Zhipeng Wang Yuanshi Li Source Type: research

A Review on the Mechanism of Tuina Promoting the Recovery of Peripheral Nerve Injury
Evid Based Complement Alternat Med. 2021 Jul 1;2021:6652099. doi: 10.1155/2021/6652099. eCollection 2021.ABSTRACTTuina, as one of the characteristic external therapies of Traditional Chinese Medicine (TCM), has been used to treat the disease caused by peripheral nerve injury (PNI) for thousands of years. An increasing number of clinical trials and animal experiments have demonstrated that tuina can improve the symptoms and promote the recovery of damaged nerves. This review focuses on the mechanistic studies of tuina in promoting the recovery of PNI, which might provide a neurobiological foundation for the effects of tuina...
Source: Evidence-based Complementary and Alternative Medicine - July 21, 2021 Category: Complementary Medicine Authors: Zhifeng Liu Hourong Wang Tianyuan Yu Yi Jiao Yingqi Zhang Di Liu Yajing Xu Qian Guan Mengqian Lu Source Type: research

A Meta-Analysis: Intervention Effect of Mind-Body Exercise on Relieving Cancer-Related Fatigue in Breast Cancer Patients
Evid Based Complement Alternat Med. 2021 Jul 3;2021:9980940. doi: 10.1155/2021/9980940. eCollection 2021.ABSTRACTOBJECTIVE: This paper aims to systematically evaluate the intervention effect of mind-body exercise on cancer-related fatigue in breast cancer patients.METHODS: Databases including PubMed, the Cochrane Library, Embase, Web of Science, CNKI, Wanfang Data, and SINOMED were retrieved to collect randomized controlled trials on the effects of mind-body exercise on relieving cancer-related fatigue in breast cancer patients. The retrieval period started from the founding date of each database to January 6, 2021. Cochra...
Source: Evidence-based Complementary and Alternative Medicine - July 21, 2021 Category: Complementary Medicine Authors: Cong Liu Man Qin Xinhu Zheng Rao Chen Jianghua Zhu Source Type: research

The Application of < em > Citrus folium < /em > in Breast Cancer and the Mechanism of Its Main Component Nobiletin: A Systematic Review
Evid Based Complement Alternat Med. 2021 Jun 29;2021:2847466. doi: 10.1155/2021/2847466. eCollection 2021.ABSTRACTCitrus folium and its main ingredient nobiletin (NOB) have received widespread attention in recent years due to their antitumor effects. The antitumor effect of Citrus folium is related to the traditional use, mainly in its Chinese medicinal properties of soothing the liver and promoting qi, resolving phlegm, and dispelling stagnation. Some studies have proved that Citrus folium and NOB are more effective for triple-negative breast cancer (TNBC), which is related to the syndrome of stagnation of liver qi. From ...
Source: Evidence-based Complementary and Alternative Medicine - July 14, 2021 Category: Complementary Medicine Authors: Yuan Wu Chien-Shan Cheng Qiong Li Jing-Xian Chen Ling-Ling Lv Jia-Yue Xu Kai-Yuan Zhang Lan Zheng Source Type: research

Effect of Omega-3 Fatty Acid Alone and in Combination with Proprietary Chromium Complex on Endothelial Function in Subjects with Metabolic Syndrome: A Randomized, Double-Blind, Parallel-Group Clinical Study
Evid Based Complement Alternat Med. 2021 Jun 25;2021:2972610. doi: 10.1155/2021/2972610. eCollection 2021.ABSTRACTMetabolic syndrome (MetS) represents a cluster of metabolic abnormalities that include hypertension, central obesity, insulin resistance, and dyslipidemia and is strongly associated with an increased risk of diabetes, cardiovascular diseases (CVD), and all-cause mortality. Early diagnosis is important to employ lifestyle and risk factor modification. Existing therapies are limited. Studies report positive effect of omega-3 fatty acids (ω-3FA) on symptoms of metabolic syndrome. The present study was undert...
Source: Evidence-based Complementary and Alternative Medicine - July 14, 2021 Category: Complementary Medicine Authors: Usharani Pingali Chandrasekhar Nutalapati Srinivas Gundagani Source Type: research

A Data Mining-Based Analysis of Core Herbs on Different Patterns (Zheng) of Non-Small Cell Lung Cancer
CONCLUSION: Applying clearing and tonifying method by targeting the lung and spleen was the most frequently used therapy in the treatment of NSCLC. This study offered a glimpse of unique views of traditional Chinese medicine on NSCLC and may benefit the treatment of NSCLC.PMID:34257676 | PMC:PMC8257336 | DOI:10.1155/2021/3621677 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - July 14, 2021 Category: Complementary Medicine Authors: Xiangjun Qi Zehuai Guo Qianying Chen Wanning Lan Zhuangzhong Chen Wenmin Chen Lizhu Lin Source Type: research

< em > Saireito < /em > Improves Lymphatic Function and Prevents UVB-Induced Acute Inflammation and Photodamage in HR-1 Hairless Mice
Evid Based Complement Alternat Med. 2021 Jun 25;2021:3707058. doi: 10.1155/2021/3707058. eCollection 2021.ABSTRACTA single high-dose ultraviolet B (UVB) exposure on the skin induces acute inflammatory responses, such as an increase in proinflammatory cytokines (e.g., IL-6 and IL-1β), hyperpermeability and dilation of blood and lymphatic vessels, and infiltration of inflammatory cells. These responses result in different cutaneous disorders characterized by erythema, epidermal hyperplasia, edema formation, and extracellular matrix degradation. Saireito extract (SRT), a traditional Chinese medicine, has been used to tre...
Source: Evidence-based Complementary and Alternative Medicine - July 14, 2021 Category: Complementary Medicine Authors: Manami Oyama Kenta Murata Misaki Ogata Nina Fujita Ryuji Takahashi Source Type: research

Efficacy and Safety of the Two Ayurveda Drug Regimens in Uterine Fibroids: A Randomized Single-Blind Clinical Trial
This study aims to assess the efficacy and safety of two Ayurveda drug regimens for the treatment of uterine fibroids (UF) in a randomized single-blind clinical trial. 120 participants with UF (volume ≥ 2 cm3) were randomly allocated at a 1 : 1 : 1 ratio to 2 experimental groups and the control group. The 12-week intervention period was followed by 12-week follow-up. The primary efficacy endpoint was the change of the largest UF volume. The secondary efficacy endpoints were assessed by the pictorial bleeding assessment score (PBAC), UF symptoms, and quality of life score. The safety endpoints were changed in hepatic and...
Source: Evidence-based Complementary and Alternative Medicine - July 14, 2021 Category: Complementary Medicine Authors: K P K R Karunagoda P K Perera H Senanayake S De Silva Weliange Source Type: research

Network Pharmacology-Based Prediction of Bioactive Compounds and Potential Targets of Wenjing Decoction for Treatment of Endometriosis
Evid Based Complement Alternat Med. 2021 Jun 24;2021:4521843. doi: 10.1155/2021/4521843. eCollection 2021.ABSTRACTEndometriosis is a chronic estrogen-dependent inflammatory disorder that negatively affects the quality of life in women. The Wenjing decoction (WJD) is a traditional Chinese medicine that has been shown to have a therapeutic effect on endometriosis. Our study systematically explored the mechanism of WJD against endometriosis using a network pharmacology approach. Potentially bioactive compounds of WJD and their possible targets were retrieved from the Traditional Chinese Medicine System Pharmacology Database a...
Source: Evidence-based Complementary and Alternative Medicine - July 14, 2021 Category: Complementary Medicine Authors: Yu-Nan Liu Xiao-Jing Hu Bei Liu Yu-Jie Shang Wen-Ting Xu Hui-Fang Zhou Source Type: research

The Herbal Formula Granule Prescription Mahuang Decoction Ameliorated Chronic Kidney Disease Which Was Associated with Restoration of Dysbiosis of Intestinal Microbiota in Rats
Evid Based Complement Alternat Med. 2021 Jun 23;2021:4602612. doi: 10.1155/2021/4602612. eCollection 2021.ABSTRACTChronic kidney disease (CKD) has become a global health issue, and there is increasing evidence showing the beneficial roles of traditional Chinese medicine (TCM) in CKD treatment. Here, we studied the renoprotective role of Mahuang decoction, a famous TCM prescription, in a rat CKD model induced with the combination of doxorubicin and adenine. Our data showed that intragastric administration of Mahuang decoction inhibited the loss of bodyweight and attenuated proteinuria, serum creatinine, and blood urea nitro...
Source: Evidence-based Complementary and Alternative Medicine - July 14, 2021 Category: Complementary Medicine Authors: Yao Ming Sijing Cheng Wen Long Hong-Lian Wang Chuanlan Xu Xiaoyu Liu Qiong Zhang Sha Zhao Xia Zou Junming Fan Li Wang Hongchun Shen Source Type: research

Therapeutic Targets and Mechanism of Xingpi Jieyu Decoction in Depression: A Network Pharmacology Study
CONCLUSIONS: This study reflects the characteristics of the mechanism of action by which XPJYD treats depression, which includes multiple components, multiple targets, and multiple pathways, and provides a biological basis for further verification and a novel perspective for drug discovery in depression.PMID:34257681 | PMC:PMC8249129 | DOI:10.1155/2021/5516525 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - July 14, 2021 Category: Complementary Medicine Authors: Ze Chang Li-Juan He Dang-Feng Tian Qiang Gao Jing-Feng Ling Yu-Chun Wang Zhen-Yun Han Rong-Juan Guo Source Type: research

LuQi Formula Regulates NLRP3 Inflammasome to Relieve Myocardial-Infarction-Induced Cardiac Remodeling in Mice
This study aimed to evaluate whether LQF could alleviate cardiac injury and apoptosis by regulating the NLRP3 inflammasome and the caspase-3/Bax pathway.PURPOSE: In this study, we investigated the effects of LQF on cardiac remodeling in a mouse model of myocardial infarction (MI) in vivo.METHODS: Forty male C57BL/6 mice were randomly divided into four groups: the sham group, the model group, the LQF group, and the perindopril group, with a sample size (n) of 10 mice in each group. Except the sham group, the other groups received left anterior descending (LAD) coronary artery ligation to induce MI and then treated with LQF,...
Source: Evidence-based Complementary and Alternative Medicine - July 14, 2021 Category: Complementary Medicine Authors: Xiaoqing Zhang Dandan Zhao Jiling Feng Xiaoli Yang Zhenzhen Lan Tao Yang Xiaoni Kong Huiyan Qu Hua Zhou Source Type: research

Traditional Chinese Medicine Constitution Correlated with Ischemic Stroke: A Systematic Review and Meta-Analysis
CONCLUSION: PDC and QDC are the common constitutions in IS patients and may have a potential correlation with the incidence of IS. Due to the low or moderate quality of included studies, more well-designed prospective studies are warranted to further evaluate the relationship between TCM constitutions and IS.PMID:34257683 | PMC:PMC8253626 | DOI:10.1155/2021/5524925 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - July 14, 2021 Category: Complementary Medicine Authors: Tianyi Zhang Hui Luo Dawei Wei Xiaolong Xie Cinyu Yang Bowen Liu Ying Gao Source Type: research

A Study on < em > Gentiana dahurica < /em > Fisch Ethanol Extract Alleviating Alcoholic Liver Disease in Mice: A Metabolomic Analysis of the Liver
Evid Based Complement Alternat Med. 2021 Jun 29;2021:5569538. doi: 10.1155/2021/5569538. eCollection 2021.ABSTRACTWe clarified the hepatoprotective effect of Gentiana dahurica Fisch ethanol extract (GDEE) in our previous study, and we further revealed the mechanism with the help of metabolomics technology in this study. The livers from Control group, Alcohol group, and Alcohol + GDEE group were analyzed by metabolomics. The metabolites in the liver were separated by ultra-high-performance liquid chromatography (UHPLC) and were tentatively identified using mass spectrometry (MS)/MS analysis. Differential metabolites were de...
Source: Evidence-based Complementary and Alternative Medicine - July 14, 2021 Category: Complementary Medicine Authors: Houkang Cao Yanxiu Guo Ling Jin Source Type: research

Antiobesity and Antidiabetic Effects of < em > Portulaca oleracea < /em > Powder Intake in High-Fat Diet-Induced Obese C57BL/6 Mice
This study investigated the hypothesis that Portulaca oleracea L. exerts antiobesity and antidiabetic effects by evaluating blood lipid profiles, blood glucose control factors, protein expression of lipid metabolism, and insulin sensitivity improvement. Three groups of high-fat diet (HFD) induced obese C57BL/6 mice (n = 8) received treatment with low (5%; HFD + PO5%) or high (10%; HFD + PO10%) concentrations of P. oleracea powder for 12 weeks or no treatment (HFD) and were compared with each other and a fourth control group. Weight gain was reduced by 34% in the HFD + PO10% group compared to the HFD group. Moreover, the pe...
Source: Evidence-based Complementary and Alternative Medicine - July 14, 2021 Category: Complementary Medicine Authors: Jae Hyun Jung Su Bin Hwang Hyeon Ju Park Guang-Ri Jin Bog Hieu Lee Source Type: research

Ethnopharmacological Survey on Medicinal Plants Used for Cosmetic Treatments in Traditional and Ayurveda Systems of Medicine in Sri Lanka
In conclusion, acquired information could ultimately be utilized for the development of the herbal cosmetic industry through the isolation and characterization of bioactive compounds from the documented plants while preserving the traditional knowledge.PMID:34257686 | PMC:PMC8257331 | DOI:10.1155/2021/5599654 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - July 14, 2021 Category: Complementary Medicine Authors: Dehel Gamage Nadeeshani Dilhara Gamage Rathnayaka Mudiyanselage Dharmadasa Don Chandana Abeysinghe Rathnayaka Gamlathge Saman Wijesekara Gamika A Prathapasinghe Takao Someya Source Type: research

Production of an Animal Model of Semi-Yin and Semi-Yang Syndrome with Diabetic Ulcers and Study of Its Pathological and Metabolic Features
CONCLUSION: SYSY syndrome presents a persistent pathological state of low inflammation, which may be caused by an insufficient activation of the M1-type metabolic pathway in macrophages in the early acute inflammatory stage, resulting in the incomplete clearance of pathogens and debris and continuous stimulation of macrophages to initiate the M1-type metabolic pathway. CD163, CD31, IL-10, and citric acid can be used as potential specific markers for the recovery and progression of SYSY syndrome.PMID:34257687 | PMC:PMC8257356 | DOI:10.1155/2021/6345147 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - July 14, 2021 Category: Complementary Medicine Authors: Yu Liu Jian-Ping Shi Wu Xiong Yang Liu Yu Yan Chao-Qi Yin Yu-Qi Jiao Xi Zhang Jian-Da Zhou Source Type: research

Resveratrol Ameliorates High-Fat-Diet-Induced Abnormalities in Hepatic Glucose Metabolism in Mice via the AMP-Activated Protein Kinase Pathway
In this study, we determined the effects of resveratrol on the insulin resistance of high-fat-diet-fed mice and a hepatocyte model by measuring serum biochemical indexes, key indicators of glycometabolism, glucose uptake, and glycogen synthesis in hepatocytes. We found that resveratrol treatment significantly ameliorated the HFD-induced abnormalities in glucose metabolism in mice, increased glucose absorption and glycogen synthesis, downregulated protein phosphatase 2A (PP2A) and activated Ca2+/CaM-dependent protein kinase kinase β (CaMKKβ), and increased the phosphorylation of AMP-activated protein kinase (AMPK)...
Source: Evidence-based Complementary and Alternative Medicine - July 14, 2021 Category: Complementary Medicine Authors: Caiping Lu Hanying Xing Linquan Yang Kaiting Chen Linyi Shu Xiaojian Zhao Guangyao Song Source Type: research

DNA Methylation in Atherosclerosis: A New Perspective
Evid Based Complement Alternat Med. 2021 Jun 23;2021:6623657. doi: 10.1155/2021/6623657. eCollection 2021.ABSTRACTAtherosclerotic cardiovascular diseases, in which atherosclerosis (AS) is the main pathologic basis, are currently the primary diseases leading to human deaths. Emerging evidence showed that DNA methylation, which could affect the transcription and expression of critical regulatory genes, has key roles in AS. Aberrant DNA methylation including aberrant hypomethylation and hypermethylation plays key roles in endothelial-cell dysfunction, macrophage inflammation, abnormal proliferation of vascular smooth muscle c...
Source: Evidence-based Complementary and Alternative Medicine - July 14, 2021 Category: Complementary Medicine Authors: Yan Zhang Jun Mei Jing Li Ying Zhang Qingbing Zhou Fengqin Xu Source Type: research

Methodological Considerations in N-of-1 Trials of Traditional Chinese Medicine
Evid Based Complement Alternat Med. 2021 Jun 23;2021:6634134. doi: 10.1155/2021/6634134. eCollection 2021.ABSTRACTMore and more scholars choose N-of-1 trials for TCM clinical research. However, the quality of the experimental designs was uneven. Accumulating more than eight years of experience in exploring the N-of-1 trials of TCM, the authors and their team searched the related literature in main Chinese and English databases, referenced to relevant Chinese and international guidelines. The design, implementation, and data analysis of N-of-1 trials of TCM are still in in-depth exploration and practice. "Carryover eff...
Source: Evidence-based Complementary and Alternative Medicine - July 14, 2021 Category: Complementary Medicine Authors: Haiyin Huang Jiaqi An Lizhi Lu Mingli Wang Huijia Chen Xinlin Chen Lihua Shen Source Type: research

Effect of High-Fat Diet  on  the Intestinal Flora in Letrozole-Induced Polycystic Ovary Syndrome Rats
Evid Based Complement Alternat Med. 2021 Jun 25;2021:6674965. doi: 10.1155/2021/6674965. eCollection 2021.ABSTRACTAIM: The aim of this study was to explore whether letrozole and high-fat diets (HFD) can induce obese insulin-resistant polycystic ovary syndrome (PCOS) with intestinal flora dysbiosis in a rat model. We compared the changes in the intestinal flora of letrozole-induced rats fed with HFD or normal chow, to explore the effects of HFD and letrozole independently and synergistically on the intestinal flora.METHODS: Five-week-old female Sprague Dawley (SD) rats were divided into four groups: control (C) group fed wi...
Source: Evidence-based Complementary and Alternative Medicine - July 14, 2021 Category: Complementary Medicine Authors: Yan-Hua Zheng Ying Xu Hong-Xia Ma Cheng-Jie Liang Tong Yang Source Type: research

An Investigation of the Antigastric Cancer Effect in Tumor Microenvironment of < em > Radix Rhei Et Rhizome < /em > : A Network Pharmacology Study
CONCLUSION: This study explored the anti-GC mechanism of RRER from the perspective of TME based on network pharmacology, which contributed to the development and application of RRER.PMID:34257692 | PMC:PMC8249119 | DOI:10.1155/2021/9913952 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - July 14, 2021 Category: Complementary Medicine Authors: Xinmiao Wang Guanghui Zhu Haoyu Yang Ruike Gao Zhe Wu Ying Zhang Xiaoyu Zhu Xiaoxiao Zhang Jie Li Source Type: research

Activity Screening of the Herb < em > Caesalpinia sappan < /em > and an Analysis of Its Antitumor Effects
Evid Based Complement Alternat Med. 2021 Jun 25;2021:9939345. doi: 10.1155/2021/9939345. eCollection 2021.ABSTRACTAIM: Traditionally, C. sappan medicine was the heartwood, which needs to be cut down as a whole. In this research, the antitumor activity and mechanisms of the leaves and stems were compared with the roots of Caesalpinia sappan; it was in order to investigate whether stems and leaves of C. sappan could be used to replace heartwood for antitumor treatment, thereby reducing resource destruction.METHODS: MTT assays were used to identify the active sites of C. sappan based on the application of human liver cancer (...
Source: Evidence-based Complementary and Alternative Medicine - July 14, 2021 Category: Complementary Medicine Authors: Yuan Li Minghong Dong Zijun Wu Yongqi Huang Haibing Qian Cong Huang Source Type: research

Alleviative Effect of < em > Ruellia tuberosa < /em > L. on Insulin Resistance and Abnormal Lipid Accumulation in TNF- < em > α < /em > -Treated FL83B Mouse Hepatocytes
In this study, we investigated the effects of RTL on glucose uptake, IR, and lipid accumulation in vitro to mimic the T2DM accompanied by the NAFLD paradigm. FL83B mouse hepatocytes were treated with tumor necrosis factor-α (TNF-α) to induce IR, coincubated with oleic acid (OA) to induce lipid accumulation, and then, treated with RTL fractions, fractionated with n-hexane or ethyl acetate (EA), from column chromatography, and analyzed by thin-layer chromatography. Our results showed that the ethyl acetate fraction (EAf2) from RTL significantly increased glucose uptake and suppressed lipid accumulation in TNF-&al...
Source: Evidence-based Complementary and Alternative Medicine - July 14, 2021 Category: Complementary Medicine Authors: Hong-Jie Chen Chih-Yuan Ko Jian-Hua Xu Yu-Chu Huang James Swi-Bea Wu Szu-Chuan Shen Source Type: research

Pycnogenol ® Supplementation Prevents Recurrent Urinary Tract Infections/Inflammation and Interstitial Cystitis
Evid Based Complement Alternat Med. 2021 Jun 23;2021:9976299. doi: 10.1155/2021/9976299. eCollection 2021.ABSTRACTThis open pilot registry study aimed to evaluate and compare the prophylactic effects of Pycnogenol® or cranberry extract in subjects with previous, recurrent urinary tract infections (UTI) or interstitial cystitis (IC). Methods. Inclusion criteria were recurrent UTI or IC. One subject group was supplemented with 150 mg/day Pycnogenol®, another with 400 mg/day cranberry extract, and a group served as a control in a 2-month open follow-up. Results. 64 subjects with recurrent UTI/IC completed the study. T...
Source: Evidence-based Complementary and Alternative Medicine - July 14, 2021 Category: Complementary Medicine Authors: A Ledda S Hu M R Cesarone G Belcaro M Dugall B Feragalli R Cotellese M Hosoi E Ippolito M Corsi R Luzzi Source Type: research

Erteng-Sanjie Capsule Enhances Chemosensitivity of 5-Fluorouracil in Tumor-Bearing Nude Mice with Gastric Cancer by Inhibiting Notch1/Hes1 Signaling Pathway
In conclusion, the findings of the study showed that ETSJC improved the chemosensitivity of 5-FU by blocking Notch1/Hes1 signaling pathway in gastric cancer-bearing mice.PMID:34257696 | PMC:PMC8249139 | DOI:10.1155/2021/9980565 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - July 14, 2021 Category: Complementary Medicine Authors: Jing Zhou Shulan Hao Hao Guo Han Yu Zhi Guo Likun Liu Source Type: research

Potential Acupoint Prescriptions and Outcome Reporting for Acupuncture in Atopic Eczema: A Scoping Review
CONCLUSIONS: This scoping review provides potential knowledge that should be considered as priority in future research of acupuncture for eczema.PMID:34257697 | PMC:PMC8257338 | DOI:10.1155/2021/9994824 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - July 14, 2021 Category: Complementary Medicine Authors: Zhiwen Zeng Man Li Yunjie Zeng Jialing Zhang Yingjie Zhao Yuanxun Lin Ruijin Qiu Dong-Shu Zhang Hong-Cai Shang Source Type: research

Anticholinesterase Activity of Eight Medicinal Plant Species: < em > In Vitro < /em > and < em > In Silico < /em > Studies in the Search for Therapeutic Agents against Alzheimer's Disease
Evid Based Complement Alternat Med. 2021 Jun 25;2021:9995614. doi: 10.1155/2021/9995614. eCollection 2021.ABSTRACTMany Bangladeshi medicinal plants have been used to treat Alzheimer's disease and other neurodegenerative diseases. In the present study, the anticholinesterase effects of eight selected Bangladeshi medicinal plant species were investigated. Species were selected based on the traditional uses against CNS-related diseases. Extracts were prepared using a gentle cold extraction method. In vitro cholinesterase inhibitory effects were measured by Ellman's method in 96-well microplates. Blumea lacera (Compositae) and...
Source: Evidence-based Complementary and Alternative Medicine - July 14, 2021 Category: Complementary Medicine Authors: Md Josim Uddin Daniela Russo Md Mahbubur Rahman Shaikh Bokhtear Uddin Mohammad A Halim Christian Zidorn Luigi Milella Source Type: research

The Application of < em > Citrus folium < /em > in Breast Cancer and the Mechanism of Its Main Component Nobiletin: A Systematic Review
Evid Based Complement Alternat Med. 2021 Jun 29;2021:2847466. doi: 10.1155/2021/2847466. eCollection 2021.ABSTRACTCitrus folium and its main ingredient nobiletin (NOB) have received widespread attention in recent years due to their antitumor effects. The antitumor effect of Citrus folium is related to the traditional use, mainly in its Chinese medicinal properties of soothing the liver and promoting qi, resolving phlegm, and dispelling stagnation. Some studies have proved that Citrus folium and NOB are more effective for triple-negative breast cancer (TNBC), which is related to the syndrome of stagnation of liver qi. From ...
Source: Evidence-based Complementary and Alternative Medicine - July 14, 2021 Category: Complementary Medicine Authors: Yuan Wu Chien-Shan Cheng Qiong Li Jing-Xian Chen Ling-Ling Lv Jia-Yue Xu Kai-Yuan Zhang Lan Zheng Source Type: research