The Effects of Various Essential Oils on Epilepsy and Acute Seizure: A Systematic Review.
Authors: Bahr TA, Rodriguez D, Beaumont C, Allred K Abstract Many essential oils (EOs) have anticonvulsant activity and might benefit people with epilepsy. Lemongrass, lavender, clove, dill, and other EOs containing constituents such as asarone, carvone, citral, eugenol, or linalool are good candidates for evaluation as antiepileptic drugs. On the other hand, some EOs have convulsant effects and may trigger seizures in both epileptic and healthy individuals. Internal use of EOs like sage, hyssop, rosemary, camphor, pennyroyal, eucalyptus, cedar, thuja, and fennel can cause epileptic seizures because they contain th...
Source: Evidence-based Complementary and Alternative Medicine - June 27, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Chelidonine Induces Caspase-Dependent and Caspase-Independent Cell Death through G2/M Arrest in the T98G Human Glioblastoma Cell Line.
Authors: Lee YK, Lee KW, Kim M, Lee Y, Yoo J, Hwangbo C, Park KH, Kim KD Abstract Chelidonium majus L. (family Papaveraceae), commonly known as greater celandine or tetterwort, has been reported to have antibacterial and anticancer effects and chelidonine is known as a functional metabolite extracted from C. PMID: 31239863 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - June 27, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Raddeanin A Induces Apoptosis and Cycle Arrest in Human HCT116 Cells through PI3K/AKT Pathway Regulation In Vitro and In Vivo.
This study aimed to investigate the in vitro and in vivo effects of Raddeanin A on apoptosis and the cell cycle in the human colorectal cell line, HCT116, and to explore the possible underlying mechanisms of action. We found the growth inhibition rate gradually increased as the drug concentration increased via the 3-(4,5)-dimethylthiahiazo(-z-y1)-3,5-di-phenytetrazoliumromide (MTT) assay, which indicated that Raddeanin A significantly inhibited the growth of HCT116 cells. Flow cytometry (FCM) showed that Raddeanin A concentration-dependently induced apoptosis in HCT116 cells. In addition, the percentage of cells in the G0/...
Source: Evidence-based Complementary and Alternative Medicine - June 27, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Analytical Method Validation of Gamijakyakgamchobuja-Tang (KCHO-1, Mecasin) Preparation.
This study is helpful to promote development of reliable manufacturing medicine and good researches through definitive quality control of Mecasin as complex herbal medicine, aiming to provide help for the treatment of ALS. PMID: 31239865 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - June 27, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Roles of Chinese Medicine and Gut Microbiota in Chronic Constipation.
Authors: Xu Z, Liu T, Zhou Q, Chen J, Yuan J, Yang Z Abstract Chronic constipation is a common gastrointestinal dysfunction, but its aetiology and pathogenesis are still unclear. Interestingly, the compositions of the gut microbiota in constipation patients and healthy controls are different. Various studies reported the different gut microbiota alterations in constipation patients, but most studies indicated that constipation patients showed the decreased beneficial bacteria and the reduced species richness of gut bacteria. Besides, the alterations in the gut microbiota may lead to constipation and constipation-re...
Source: Evidence-based Complementary and Alternative Medicine - June 27, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Cynomorium songaricum Extract Alleviates Memory Impairment through Increasing CREB/BDNF via Suppression of p38MAPK/ERK Pathway in Ovariectomized Rats.
Authors: Tian FZ, Chang HS, Liu JX, Zheng J, Cheng D, Lu Y Abstract Cynomorium songaricum Rupr is a very important traditional Chinese medicine for tonifying the kidney, which has a significant effect on improving estrogen level on the long term. In many studies, it can improve the learning and memory function of ovariectomized (OVX) model animals. 10 of the 50 rats received only bilateral back surgery and were harvested with the same amount of fat as the ovaries without removing the ovaries as sham group; remains underwent bilateral ovariectomy and equally randomized into five groups: sham group, with OVX as model...
Source: Evidence-based Complementary and Alternative Medicine - June 27, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

A 4-Week Repeated Oral Dose Toxicity Study of Ssanghwa-Tang in Crl:CD Sprague Dawley Rats.
Authors: Yoo SR, Ha H, Lee MY, Shin HK, Han SC, Seo CS Abstract Ssanghwa-tang (SHT), a traditional herbal formula, has been widely used to recover fatigue or consumptive disease after an illness. Along with much attention to herbal formula, the concerns about the safety and toxicity have arisen. To establish the safety information, SHT was administrated in Crl:CD Sprague Dawley rats at a daily dose of 0, 1000, 2000, and 5000 mg/kg for 4 weeks. During the test periods, we examined the mortality, clinical observation, body weight change, food consumption, organ weights, hematology, serum biochemistry, and urinalysis ...
Source: Evidence-based Complementary and Alternative Medicine - June 23, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

The Neuroscience of Nonpharmacological Traditional Chinese Therapy (NTCT) for Major Depressive Disorder: A Systematic Review and Meta-Analysis.
Authors: Ye J, Cheung WM, Tsang HWH Abstract Background: Depression is a common disease affecting a large number of people across the world. Many researchers have focused on treatment for depression based on Western scientific approaches, but research based on traditional Chinese medicine (TCM) interventions, studying its clinical effectiveness and the underlying mechanisms involved, has been limited. The aim of this review is to conduct a pioneering systematic review with meta-analysis of existing studies that investigate the neuroscience basis of nonpharmacological traditional Chinese therapy (NTCT). Methods:...
Source: Evidence-based Complementary and Alternative Medicine - June 23, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Effect of Kinesio Taping on the Walking Ability of Patients with Foot Drop after Stroke.
Authors: Sheng Y, Kan S, Wen Z, Chen W, Qi Q, Qu Q, Yu B Abstract Objective: The purpose of this study was to investigate the effect of kinesio taping on the walking ability in patients with foot drop after stroke. Methods: Sixty patients were randomly divided into the experimental group (with kinesio taping) and the control group (without kinesio taping). The 10-Meter Walking Test (10MWT), Timed Up and Go Test (TUGT), stride length, stance phase, swing phase, and foot rotation of the involved side were measured with the German ZEBRIS gait running platform analysis system and were used to evaluate and compare t...
Source: Evidence-based Complementary and Alternative Medicine - June 23, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Neuroprotective Effects of Anthraquinones from Rhubarb in Central Nervous System Diseases.
Authors: Li X, Chu S, Liu Y, Chen N Abstract Rhubarb is a well-known traditional Chinese medicine; it has been used in China for thousands of years. Rhubarb anthraquinones are the major medicinal ingredients derived from rhubarb including emodin, aloe-emodin, chrysophanol, rhein, physcion, and danthron. These different anthraquinone derivatives alone or in combination play a therapeutic role in central nervous system diseases (CNSD), such as cerebral ischemic stroke, intracerebral hemorrhage, traumatic brain injury, brain tumor, Alzheimer's disease, depression, and others. We review the experimental studies on thes...
Source: Evidence-based Complementary and Alternative Medicine - June 23, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Rho-Kinase II Inhibitory Potential of Eurycoma longifolia New Isolate for the Management of Erectile Dysfunction.
Authors: Ezzat SM, Okba MM, Ezzat MI, Aborehab NM, Mohamed SO Abstract Background. Eurycoma longifolia Jack (Fam.: Simaroubaceae), known as Tongkat Ali (TA), has been known as a symbol of virility and sexual power. The aim of the study was to screen E. longifolia aqueous extract (AE) and isolates for ROCK-II inhibition. Results. The AE (1-10 μg/ml) showed a significant inhibition for ROCK-II activity (62.8-81%) at P
Source: Evidence-based Complementary and Alternative Medicine - June 23, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Proteomic Assessment of iTRAQ-Based NaoMaiTong in the Treatment of Ischemic Stroke in Rats.
In this study, we used iTRAQ using 2D LC-MS/MS technology to investigate the cellular mechanisms governing the protective effects of NMT. The transient middle cerebral artery occlusion (MCAO) rat model was established and evaluated. The degree of cerebral ischemia was assessed through scoring for nerve injury symptoms and through the assessment of the areas of cerebral infarction. Brain tissues were subjected to analysis by iTRAQ. High-pH HPLC and RSLC-MS/MS analysis were performed to detect differentially expressed proteins (DEPs) between the treatment groups (Sham, MCAO, and NMT). Bioinformatics were employed for data an...
Source: Evidence-based Complementary and Alternative Medicine - June 23, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Influence of the Intensity, Components, and Spreading of the Deqi Sensation on the Analgesic Effect of SP6 Needling in Primary Dysmenorrhea Patients: A Secondary Analysis of a Randomised Controlled Trial.
Authors: Hu NJ, Liu YQ, Zhao MY, Wang P, Wu GW, Hu SQ, Sun JJ, Wang YF, Zhang Z, Ma LX, Zhu J Abstract Although deqi, the phenomenon whereby excitation of Qi in the meridians occurs with needling, is critical to the practice of acupuncture and its efficacy, it is poorly understood. So we investigate the influence of the deqi sensation on the analgesic effects of acupuncture in patients who were enrolled in a randomised controlled trial for the treatment of patients with primary dysmenorrhea, a painful and common condition, and cold and dampness stagnation. Two groups were assessed: a deqi group (undergoing deep nee...
Source: Evidence-based Complementary and Alternative Medicine - June 23, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Phyllanthus muellerianus (Euphorbiaceae) Restores Ovarian Functions in Letrozole-Induced Polycystic Ovarian Syndrome in Rats.
Authors: Ndeingang EC, Defo Deeh PB, Watcho P, Kamanyi A Abstract Polycystic ovarian syndrome (PCOS) is one of the common causes or female infertility. Phyllanthus muellerianus (Euphorbiaceae) is a plant used to treat various ailments including frequent menstruation and anovulation. We investigated the effects of P. muellerianus extracts on estrus cyclicity, lipid profile, oxidative stress-related markers, sex hormones, and ovarian architecture in letrozole-induced PCOS in rats. After induction of PCOS using letrozole (1 mg/kg/day), normal (n=6), and PCOS (n=108; distributed into 18 groups of 6 animals/group...
Source: Evidence-based Complementary and Alternative Medicine - June 22, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Kihito, a Traditional Japanese Kampo Medicine, Improves Cognitive Function in Alzheimer's Disease Patients.
Authors: Watari H, Shimada Y, Matsui M, Tohda C Abstract Background and Aims: We previously reported that the administration of traditional Japanese medicines, kihito (Gui-Pi-Tang in Chinese) and kamikihito (Jia-Wei-Gui-Pi-Tang in Chinese), to Alzheimer's disease (AD) model mice improved memory impairment. There are a few reports that show kihito and kamikihito have a beneficial effect on the cognitive function of AD patients in clinical studies. However, these studies are not comparative and are retrospective studies; thus, more evidence is needed. Therefore, we conducted an open-label, crossover designed clinical...
Source: Evidence-based Complementary and Alternative Medicine - June 22, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Effect of Electroacupuncture on Hyperalgesia and Vasoactive Neurotransmitters in a Rat Model of Conscious Recurrent Migraine.
In conclusion, EA exerts antihyperalgesic effect in a rat model of conscious recurrent migraine, possibly via modulation of the vasoactive neurotransmitters. Furthermore, targeting multiple acupuncture points is more effective than targeting a single point in reducing hyperalgesia. PMID: 31217804 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - June 22, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Identify the Key Active Ingredients and Pharmacological Mechanisms of Compound XiongShao Capsule in Treating Diabetic Peripheral Neuropathy by Network Pharmacology Approach.
Authors: Yu M, Song X, Yang W, Li Z, Ma X, Hao C Abstract Compound XiongShao Capsule (CXSC), a traditional herb mixture, has shown significant clinical efficacy against diabetic peripheral neuropathy (DPN). However, its multicomponent and multitarget features cause difficulty in deciphering its molecular mechanisms. Our study aimed to identify the key active ingredients and potential pharmacological mechanisms of CXSC in treating DPN by network pharmacology and provide scientific evidence of its clinical efficacy. CXSC active ingredients were identified from both the Traditional Chinese Medicine Systems Pharmacolog...
Source: Evidence-based Complementary and Alternative Medicine - June 20, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Huangqi Shengmai Yin Protects against Radiation-Induced Cardiac Fibrosis Injury by Regulating the TGF- β1/Smads and MMPs.
Conclusions: The involvement of the TGF-β1/Smads and MMPs/TIMP system in RICF was confirmed. This study demonstrated, for the first time, that HSY attenuates the effects of RICF in a rat model. The effect HSY was found to be closely related to the TGF-β1/Smads signaling pathway and MMPs system. These results suggest that HSY is a prospective drug for clinical treatment of RICF. PMID: 31214266 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - June 20, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Nigella sativa L. (Black Cumin): A Promising Natural Remedy for Wide Range of Illnesses.
Authors: Yimer EM, Tuem KB, Karim A, Ur-Rehman N, Anwar F Abstract The seed of Nigella sativa (N. sativa) has been used in different civilization around the world for centuries to treat various animal and human ailments. So far, numerous studies demonstrated the seed of Nigella sativa and its main active constituent, thymoquinone, to be medicinally very effective against various illnesses including different chronic illness: neurological and mental illness, cardiovascular disorders, cancer, diabetes, inflammatory conditions, and infertility as well as various infectious diseases due to bacterial, fungal, parasitic,...
Source: Evidence-based Complementary and Alternative Medicine - June 20, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Uncovering the Pharmacological Mechanism of Chaibei Zhixian Decoction on Epilepsy by Network Pharmacology Analysis.
Conclusions: Network pharmacology approach provides better understanding of the underlying pharmacological mechanisms of CZD on epilepsy. Estradiol, ESR1, ESR2, CTNNB1, EP300, MAPK1, MAPK3, BRCA1, and GSK3B are likely to be important molecules regulated by CZD in treatment of epilepsy. Negative regulation of protein kinase B signaling may play vital roles in the treatment of epilepsy by CZD. PMID: 31214268 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - June 20, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Nephroprotective Effect of Herbal Extract Eurycoma longifolia on Paracetamol-Induced Nephrotoxicity in Rats.
Authors: Chinnappan SM, George A, Thaggikuppe P, Choudhary Y, Choudhary VK, Ramani Y, Dewangan R Abstract Paracetamol (PCM) is a well-known drug widely used for its analgesic and antipyretic properties. PCM is generally considered as safe but overdose of PCM can cause nephrotoxicity. Traditionally, herbs have been used for the treatment of drug or toxin-induced renal disorders and numerous medicinal plants were tested for nephroprotection effect in PCM-induced nephrotoxicity model. The aim of the present study was to evaluate the protective effect of the herbal extract Eurycoma longifolia (EL) against PCM-induced n...
Source: Evidence-based Complementary and Alternative Medicine - June 20, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Anatomy of the Cun Position at Wrist and Its Application in Pulse Diagnosis.
The objective was to investigate the boundaries and contents, and the vascular distribution and their pulse points in Cun. Thirty-two upper extremities of 16 human cadavers were investigated for dissection and observation. The boundaries, contents, and blood vessel distribution in Cun were observed; the location of pulse points in Cun was identified; the length of the superficial palmar branch in wrist pulse (L1), the pulp width of the index finger (L2), and the angle between the radial artery and the superficial palmar branch were measured. The results showed that the Cun was located in the region formed by the bulge of t...
Source: Evidence-based Complementary and Alternative Medicine - June 19, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Novel Acaricidal Drug Fluazuron Causes Immunotoxicity via Selective Depletion of Lymphocytes T CD8.
Authors: Ribeiro JG, Soares AS, Chaves PEE, Limberger JT, da Rosa E, Zuravski L, de Oliveira LFS, Machado MM Abstract Fluazuron is one of the newest veterinary antitick medicines. Belonging to the benzoylphenylureas group, its mechanism of action acts by the interference of the formation of the chitin of the tick, which is responsible for the hardening of its exoskeletons. In addition to taking care of the health of the animal so that it receives the medication in the doses and the correct form, it is important to analyze the safety of the operator. Reduced resistance to infectious disease was a well-documented con...
Source: Evidence-based Complementary and Alternative Medicine - June 19, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Does Adjuvant Treatment with Chinese Herbal Medicine to Antidiabetic Agents Have Additional Benefits in Patients with Type 2 Diabetes? A System Review and Meta-Analysis of Randomized Controlled Trials.
Authors: Jin, Tian J, Bao Q, Zhang H, Ding Q, Lian F, Xiao-Lin T Abstract Introduction: In the present meta-analysis, we aimed to determine the effects of adjuvant treatment with Chinese herbal medicine (CHM) on antidiabetic agents having additional benefits in patients with type 2 diabetes. Methods: Randomized controlled trials were identified by searching the Cochrane Library, PUBMED, EMBASE, MEDLINE, the China National Knowledge Internet, Web of Science, Global Health, International Pharmaceutical Abstracts and the China biology medicine, Wanfang, and VIP databases. The intervention group received CHM as add...
Source: Evidence-based Complementary and Alternative Medicine - June 16, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Advances in Metabolic Profiling and Pharmacokinetics of Herbal Medicinal Products.
Authors: Liu X, Ai Y, Ma J PMID: 31198429 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - June 16, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Initial Effects of Electroacupuncture for Chronic Severe Functional Constipation and the Potential Underlying Factors: Secondary Analysis of a Randomized Controlled Trial.
Authors: Zeng Y, Liu Y, Liu S, Liu Z Abstract Background: Electroacupuncture (EA) has been found to be effective for treating chronic severe functional constipation (CSFC). However, the initial effects of treatment usually affect the acceptability and compliance of patients with chronic disease in particular. Which class of CSFC patients will have a better initial response to EA remains uncertain and requires investigation. Methods: This was a secondary analysis of an original multicenter randomized controlled trial in which patients with CSFC were randomly assigned to receive 28 sessions of EA or sham electroa...
Source: Evidence-based Complementary and Alternative Medicine - June 16, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Medicinal Properties and Active Constituents of Dracocephalum kotschyi and Its Significance in Iran: A Systematic Review.
Conclusion: This review has shown that D. kotschyi is an important medicinal plant with a large number of active constituents and great potential to safeguard human and animal health in Iran. However, over utilization of the D. kotschyi plant is already endangering its existence. Nevertheless, more studies need be conducted across the country. PMID: 31198431 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - June 16, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Methanolic Extract of Artemia salina Eggs and Various Fractions in Different Solvents Contain Potent Compounds That Decrease Cell Viability of Colon and Skin Cancer Cell Lines and Show Antibacterial Activity against Pseudomonas aeruginosa.
This study demonstrated promising anticancer and antibacterial effects of Artemia salina egg extracts. Our results suggest that pure bioactive compounds obtained from Artemia salina eggs can provide new insights into the mechanisms of colon and skin cancer, as well as Pseudomonas aeruginosa inhibition. PMID: 31198432 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - June 16, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Central and Peripheral Mechanism of Acupuncture Analgesia on Visceral Pain: A Systematic Review.
Conclusions: Acupuncture reduced visceral pain behavior and induced significant changes in neuronal activity as well as in the levels of pain/inflammation-related cytokines and neurotransmitters in the brain-gut axis. Further researches on the thalamus and on a standard animal model are warranted to improve our knowledge on the mechanism of acupuncture that facilitates visceral pain modulation. PMID: 31186654 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - June 14, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

The Wound Healing Effect of Callicarpa nudiflora in Scalded Rats.
Authors: Zhang XG, Li XM, Zhou XX, Wang Y, Lai WY, Liu Y, Luo YC, Zhang JQ Abstract Callicarpa nudiflora has been widely used in Li nationality medicine and treated burns and scalds in China. Our objective was to preliminarily elucidate healing effect and action mechanism of Callicarpa nudiflora water extract (CNE) on the scald wounds using an experimental rat mode. The second-degree scald wounds were induced by hot water on dorsal surface of Sprague-Dawley (SD) rats, and then they were randomly divided into 5 groups as follows: control (CON), Vaseline, Silver sulfadiazine (SSD), and Vaseline supplemented with 10% ...
Source: Evidence-based Complementary and Alternative Medicine - June 14, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Acupuncture Treatment for Symptom Management in Atopic Dermatitis: A Study Protocol for a Randomized, Participant- and Assessor-Blind, Sham-Controlled Trial.
This study will assess acupuncture treatment for the alleviation of AD symptoms in patients with mild-to-moderate AD. This clinical trial gas been registered in Korean Clinical Trial Registry (registration number: KCT0002796; date of registration: April 13, 2018). PMID: 31186656 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - June 14, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

A Validated HPLC-MS/MS Method for Simultaneous Determination of Militarine and Its Three Metabolites in Rat Plasma: Application to a Pharmacokinetic Study.
Authors: Sun HY, Zheng L, Gong ZP, Li YT, Yang C, Pan J, Wang YL, Wang AM, Li YJ, Huang Y Abstract A rapid, reliable, and sensitive HPLC-electrospray ionization-tandem mass spectrometry (HPLC-MS/MS) method was established and validated for simultaneous determination of militarine and its three metabolites (gastrodin, α-isobutylmalic acid, and gymnoside I) in rat plasma. Plasma was acidified with formic acid, and protein was precipitated with methanol. MS/MS with ESI and multiple reaction monitoring at m/z 725.3→457.3, 457.1→127, 304.3→107.2, 189→129, and 417.1→267.1 was used for deter...
Source: Evidence-based Complementary and Alternative Medicine - June 14, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Alpha7 nAChR Expression Is Correlated with Arthritis Development and Inhibited by Sinomenine in Adjuvant-Induced Arthritic Rats.
This study investigated the relationship between α7nAChR and RA development and the effects of SIN on α7nAChR expression in vivo and in vitro. Sprague-Dawley rats were injected with complete Freund's adjuvant to induce arthritis and then treated with SIN or methotrexate (MTX) from day 0 to day 30. Four clinical parameters-paw volume, arthritic index (AI), serum TNF-α concentration, and erythrocyte sedimentation rate (ESR)-were measured. Splenic lymphocytes were isolated for Bacille Calmette Guerin (BCG) stimulation. α7nAChR expression in tissues and cells was examined by RT-PCR, western blot, immuno...
Source: Evidence-based Complementary and Alternative Medicine - June 14, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Natural Products and/or Isolated Compounds on Wound Healing.
Authors: Agyare C, Akindele AJ, Steenkamp V PMID: 31186659 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - June 14, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Antioxidative and Antimelanogenesis Effect of Momordica charantia Methanol Extract.
Authors: Park SH, Yi YS, Kim MY, Cho JY Abstract Despite a large number of studies reporting a variety of biological and pharmacological activities of Momordica charantia, its skin protective properties are poorly understood. The present study aimed to explore the skin protective properties of Momordica charantia methanol extract (Mc-ME) and the underlying mechanism in keratinocytes, fibroblasts, and melanocytes. Mc-ME exhibited an antioxidative property by decreasing radical levels in HaCaT keratinocytes and a cytoprotective property in H2O2-damaged HaCaT cells, which was mediated by increasing the expression or a...
Source: Evidence-based Complementary and Alternative Medicine - June 14, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Qingshen Buyang Formula Attenuates Renal Fibrosis in 5/6 Nephrectomized Rats via Inhibiting EMT and Wnt/ β-Catenin Pathway.
Qingshen Buyang Formula Attenuates Renal Fibrosis in 5/6 Nephrectomized Rats via Inhibiting EMT and Wnt/β-Catenin Pathway. Evid Based Complement Alternat Med. 2019;2019:5370847 Authors: Zhang X, Fang J, Chen Z, Zhao B, Wu S, Pan Y Abstract As renal fibrosis significantly contributes to various kinds of chronic kidney diseases, this study aimed to investigate the renal protective effects of Qingshen Buyang Formula against renal fibrosis on 5/6 nephrectomized rats, and its underlying mechanisms were explored. A total of 24 male Sprague-Dawley rats were randomly divided into sham operation group (Sha...
Source: Evidence-based Complementary and Alternative Medicine - June 14, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Erjingwan Extracts Exert Antiaging Effects of Skin through Activating Nrf2 and Inhibiting NF- κB.
We examined the antiaging effects of EJW extracts on healthy human skin by noninvasive measurements. Then we estimated the cell proliferation and DPPH radical scavenging rate. Western blotting analysis was used to determine the expressions of matrix metalloproteinase-1 (MMP-1), type I collagen (COL1A2), p-NF-κB, NF-κB, p-IκBα, IκBα, p-Nrf2, and HO-1. EJW extracts did not affect moisture content, TEWL and skin chroma, while it significantly improved skin glossiness and skin elasticity. Moreover, EJW extracts could downregulate the MMP1 expression and upregulate the COL1A2 expression. In a...
Source: Evidence-based Complementary and Alternative Medicine - June 14, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Comparative Phytochemical Analysis and Antioxidant Activities of Tamalakyadi Decoction with Its Modified Dosage Forms.
Conclusion: Freeze dried TD is the most suitable ready to use preparation having similar chemical properties and antioxidant activities to TD. PMID: 31186663 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - June 14, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Kangquan Recipe Regulates the Expression of BAMBI Protein via the TGF- β/Smad Signaling Pathway to Inhibit Benign Prostatic Hyperplasia in Rats.
Conclusions: In the model of BPH induced by testosterone propionate after castration, KQR can inhibit the conduction of the TGF-β/Smad signaling pathway by upregulating the expression of BAMBI protein and reversing EMT in rat prostate tissue. PMID: 31186664 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - June 14, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Metabolic Response in Rats following Electroacupuncture or Moxibustion Stimulation.
Authors: Xu J, Lin X, Cheng KK, Zhong H, Liu M, Zhang G, Shen G, Dong J Abstract Electroacupuncture and moxibustion are traditional Chinese medicine practices that exert therapeutic effects through stimulation of specific meridian acupoints. However, the biological basis of the therapies has been difficult to establish; thus the current practices still rely on ancient TCM references. Here, we used a rat model to study perturbations in cortex, liver, and stomach metabolome and plasma hormones following electroacupuncture or moxibustion treatment on either stomach meridian or gallbladder meridian acupoints. All treat...
Source: Evidence-based Complementary and Alternative Medicine - June 14, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Development of a Yoga-Based Cardiac Rehabilitation (Yoga-CaRe) Programme for Secondary Prevention of Myocardial Infarction.
In conclusion, a novel yoga-based CR programme has been developed, which promises to provide a scalable CR solution for India and an alternative choice for CR globally. It is currently being evaluated in a large multicentre randomised controlled trial across India. PMID: 31186666 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - June 14, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Effect of Xylocarpus granatum Bark Extract on Amelioration of Hyperglycaemia and Oxidative Stress Associated Complications in STZ-Induced Diabetic Mice.
Authors: Das SK, Prusty A, Samantaray D, Hasan M, Jena S, Patra JK, Samanta L, Thatoi H Abstract Xylocarpus granatum is a medicinal mangrove plant, traditionally used for the treatment of diarrhoea, cholera, fever, dyslipidaemia, inflammation, etc. The present study was aimed to evaluate the in vitro antidiabetic (α-glucosidase inhibition assay) and antioxidant (ABTS scavenging and metal chelating assay) activities of ethanol, methanol, and aqueous extracts of leaves and barks of X. granatum followed by in vivo antidiabetic and antioxidant evaluation of ethanol bark extracts in streptozotocin- (STZ-) induced ...
Source: Evidence-based Complementary and Alternative Medicine - June 14, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Evaluation of the Effect of Aqueous Momordica charantia Linn. Extract on Zebrafish Embryo Model through Acute Toxicity Assay Assessment.
Authors: Thiagarajan SK, Rama Krishnan K, Ei T, Husna Shafie N, Arapoc DJ, Bahari H Abstract Momordica charantia Linn., commonly known as bitter gourd, has many protective roles due to its medicinal value as it contains bioactive components. However, this extract showed possible toxicity effect on zebrafish embryo. Thus this study was designed to differentiate the toxicity activities in two types of M. charantia sample which are Indian and Chinese M. charantia, as well as to compare between two different aqueous extraction methods, hot and cold aqueous method, using zebrafish embryo assay assessment. It was observe...
Source: Evidence-based Complementary and Alternative Medicine - June 14, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Sleep Promoting Effects of IQP-AO-101: A Double-Blind, Randomized, Placebo-Controlled Exploratory Trial.
Authors: Bongartz U, Tan BK, Seibt S, Bothe G, Uebelhack R, Chong PW, Wszelaki N Abstract Objective: The purpose of this study was to explore the clinical benefit and tolerability of IQP-AO-101 in healthy subjects with sleep complaints. Methods: This double-blind, randomized, placebo-controlled trial involved fifty subjects with sleep complaints. Subjects with a Pittsburgh Sleep Quality Index (PSQI) score between 6 and 15 were randomized to receive either IQP-AO-101 or placebo for 6 weeks, following a run-in period of one week. Sleep parameters were assessed at baseline and after 1, 4, and 6 weeks using the mod...
Source: Evidence-based Complementary and Alternative Medicine - June 14, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Traditional Herbal Formula Taeeumjowi-Tang (TJ001) Inhibits p53-Mutant Prostate Cancer Cells Growth by Activating AMPK-Dependent Pathway.
Authors: Kang S, Kim HI, Choi YJ, Lee SK, Kim JH, Cheon C, Ko SG Abstract Dysregulated lipid metabolism is a prominent feature of prostate cancers (PCas); several enzymes involved in lipid accumulation are highly expressed. Here, we elucidated efficacy of TJ001, a traditional herbal decoction, in inhibiting de novo lipogenesis. TJ001 had significant cytotoxicity against DU145 but not PC3 and LNCaP cells and, similarly, TJ001 markedly AMPK phosphorylation only in DU145 cells. This was accompanied by the downregulation of phosphorylated-acetyl coenzyme A carboxylase (ACC) expression and sterol regulatory element-bind...
Source: Evidence-based Complementary and Alternative Medicine - June 14, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Metabolic and Epigenetic Action Mechanisms of Antidiabetic Medicinal Plants.
In conclusion, this review article presents the mechanistic insight of phytochemicals in the treatment of diabetes by combining both the cellular systems biology and molecular modeling. PMID: 31191707 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - June 14, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Clinical Effect of Intravenous Vitamin C on Viral Myocarditis in Children: A Systematic Review and Meta-Analysis.
Authors: Chen S, Zhao W, Zhang B, Jia Y, Wu S, Zhong B, Yu X, Wang X, Hao Y, Wang H, Zhao Y, Mizuno K, Bu H, Tseng Y Abstract Objective: To comprehensively compare the effects of conventional therapy combined with intravenous vitamin C and conventional therapy on viral myocarditis in children through a meta-analysis. Methods: Relevant articles including clinical trials of normal treatment combined with intravenous vitamin C and conventional therapy for viral myocarditis in children that were published between January 2000 and February 2018 were selected from PubMed, Cochrane Library, China National Knowledge In...
Source: Evidence-based Complementary and Alternative Medicine - June 12, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

In Vitro and In Vivo Anti-Salmonella Evaluation of Pectin Extracts and Hydrolysates from "Cas Mango" (Spondias dulcis).
Conclusion: The present study highlights the potential of pectin oligosaccharides as new source of anti-Salmonella drugs. Further investigations including exploration of mechanism of action of the most active pectin extracts/hydrolysates are envisaged. PMID: 31178915 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - June 12, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Preliminary Comparison of the Efficacy and Safety of Needle-Embedding Therapy with Acupuncture for Atopic Dermatitis Patients.
Conclusions: Based on changes in the SCORAD index, TEWL, skin hydration, and DLQI value, we found that both needle-embedding and acupuncture treatments at the Quchi acupoint (LI11) were effective in decreasing the symptoms of AD and exhibited similar therapeutic effects, which suggests that needle-embedding treatment may be more clinically convenient than acupuncture, with longer effects and fewer treatments. PMID: 31178916 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - June 12, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Antidiabetic and Antihyperlipidemic Activities of the Leaf Latex Extract of Aloe megalacantha Baker (Aloaceae) in Streptozotocin-Induced Diabetic Model.
This study aimed to evaluate the antidiabetic and antihyperlipidemic effects of the leaf latex extract of A. megalacantha in streptozotocin- (STZ-) induced diabetic model. Methods: The experimental diabetes was induced in Swiss albino mice by the administration of a single dose of STZ (150 mg/kg), intraperitoneally. The leaf latex extract of A. megalacantha at three different doses (100, 200, and 400 mg/kg) was administered for a period of 14 days. Fasting blood glucose levels (BGLs) were measured by glucose-oxidase and peroxidase reactive strips. After fourteen days, mice from all groups fasted and the blood was colle...
Source: Evidence-based Complementary and Alternative Medicine - June 12, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research