Effects of Genital Nerve Stimulation Amplitude on Bladder Capacity in Spinal Cord Injured Subjects.
Conclusion: This study demonstrates a linear correlation between the stimulation amplitude ranging from 1 to 4T and bladder capacity gain in individuals with SCI in acute GNS experiments. However, GNS amplitude out of the range of 1-4T might not be exactly a linear relationship due to subthreshold or saturation factors. Thus, further research is needed to examine this issue. Nevertheless, these results may be critical in laying the groundwork for understanding the effectiveness of acute GNS in the treatment of neurogenic detrusor overactivity. PMID: 31341487 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - July 27, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Jiedu Sangen Decoction Inhibits the Invasion and Metastasis of Colorectal Cancer Cells by Regulating EMT through the Hippo Signaling Pathway.
Authors: Yuan L, Zhou M, Wasan HS, Zhang K, Li Z, Guo K, Shen F, Shen M, Ruan S Abstract Colorectal cancer (CRC) is one of the most common malignant tumors affecting the digestive tract. Moreover, the invasion and metastasis of CRC are the main reason therapy is usually inefficient. Decreased intercellular adhesion and enhanced cell motility induced by epithelial-mesenchymal transition (EMT) provide the basic conditions for the invasion and metastasis of the epithelial tumor cells of CRC. The Jiedu Sangen Decoction (JSD) is a prescription that has been used for more than 50 years in the treatment of CRC in the Zhej...
Source: Evidence-based Complementary and Alternative Medicine - July 27, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Salvia officinalis, Rosmarinic and Caffeic Acids Attenuate Neuropathic Pain and Improve Function Recovery after Sciatic Nerve Chronic Constriction in Mice.
This study was conducted to investigate the curative effects of Salvia officinalis (SO) and its major constituents Rosmarinic (ROS) and Caffeic acids (CAF) on peripheral neuropathic pain in mice. Chronic constriction injury (CCI) was induced in mice, and neuropathic pain behaviors tests were evaluated by mechanical, chemical, thermal sensation tests and functional recovery of the sciatic nerve at different time intervals, i.e., (day 0, 1, 7, 14, and 21). Ethanolic extract of SO (100 and 200 mg/kg, p.o.), ROS (10 and 20 mg/kg, i.p.), CAF (30 and 40 mg/kg, i.p.), and CLOM (5 mg/kg, i.p., a positive control) was given for 21 ...
Source: Evidence-based Complementary and Alternative Medicine - July 27, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Integrated Metabolomics and Network Pharmacology Study on Immunoregulation Mechanisms of Panax ginseng through Macrophages.
In conclusion, our results indicated that PG may be prone to polarize macrophages to M2 phenotype by mainly regulating the glutathione and choline metabolism, which was related to twenty compounds of PG. PMID: 31341490 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - July 27, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Utilization of Complementary and Alternative Therapies in Youth with Developmental Disabilities.
This study examines the use of these therapies among 10,218 children between the ages of 4 and 17 using the 2012 Child Complementary and Alternative Medicine (CAM) Supplement of the National Health Interview Survey (NHIS) to highlight a potential avenue for intervention and prevention efforts. The results suggest that children with developmental disabilities are more likely to utilize particular CAM therapies that may alter oxidative stress pathways. Future work is needed to assess the potential moderating effect of these CAM therapies and oxidative stress levels among children with different developmental disabilities. ...
Source: Evidence-based Complementary and Alternative Medicine - July 27, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Metabolomic Study on Nude Mice Models of Gastric Cancer Treated with Modified Si Jun Zi Tang via HILIC UHPLC-Q-TOF/MS Analysis.
In conclusion, we established a HILIC UHPLC-Q-TOF/MS metabolomic analysis method to demonstrate a complex metabolic profile of gastric cancer. The disordered metabolism could be partially regulated by MSJZT. These findings not only establish a solid foundation for TCM to treat gastric cancer but also provide a basis for further exploration of the precise mechanism of MSJZT activity. PMID: 31341492 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - July 27, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

In Vivo Study on the Effects of Xiaoaiping on the Stemness of Hepatocellular Carcinoma Cells.
Conclusion: Xiaoaiping significantly inhibited the growth of HCC xenograft in nude mice. These antitumor effects may be mediated by modulating the expression of multiple stemness markers and totipotency factors and inhibition of the Hippo, Wnt, and Hedgehog signaling pathways. PMID: 31341493 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - July 27, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Tityus serrulatus Scorpion Venom Induces Apoptosis in Cervical Cancer Cell Lines.
In this study, we investigated the effect of Tityus serrulatus scorpion venom (TsV) on CC lines. There are very few studies exploring venom of scorpions, and, to our knowledge, no study has been conducted using the venom of the scorpion TsV for treatment of cervical cancer lines. After challenge with TsV, the MTT assay demonstrated cytotoxic effect on HeLa line. Similarly, the cell death process in HeLa analyzed by flow cytometry suggests death via caspase, since the pan-caspase inhibitor z-VAD-fmk significantly reduced the apoptotic response to the treatment. These results suggest that venom of TsV can be a potential sour...
Source: Evidence-based Complementary and Alternative Medicine - July 27, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Acupuncture for Chronic Pain-Related Insomnia: A Systematic Review and Meta-Analysis.
Authors: Liu F, You J, Li Q, Fang T, Chen M, Tang N, Yan X Abstract Objectives. Acupuncture has been widely used to relieve chronic pain-related insomnia (CPRI). However, the efficacy of acupuncture for CPRI is uncertain. The purpose of this study was to evaluate the efficacy of acupuncture for CPRI. Methods. Seven electronic databases were searched from inception to December 2018. Randomized controlled trials (RCTs) were included if acupuncture was compared to sham acupuncture or conventional drug therapies for treating CPRI. Two reviewers screened each study and extracted data independently. Statistical analyses ...
Source: Evidence-based Complementary and Alternative Medicine - July 27, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Protective Effects of Nutria Bile against Thioacetamide-Induced Liver Injury in Mice.
Authors: Kong JY, Yeon SC, Lee HJ, Kang C, Park JK, Jeong KS, Hong IH Abstract Several eradication programs have been developed and executed to curb alien invasive species that tend to damage the ecological environments they colonize; however, only few studies have evaluated the utilization of carcasses of these species after eradication. Nutria (Myocastor coypus) is an invasive rodent species targeted by eradication programs in many countries. We noted that nutria produce large amounts of ursodeoxycholic acid (UDCA) in their bile. UDCA is a unique component responsible for the anti-inflammatory and hepatoprotectiv...
Source: Evidence-based Complementary and Alternative Medicine - July 27, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Acupuncture for Premenstrual Syndrome at Different Intervention Time: A Systemic Review and Meta-Analysis.
Conclusions: The current meta-analysis reveals that acupuncture leads to better effective rate, but the intervention time has no significant effect on the efficacy of acupuncture treatment for PMS. SP6, LR3, and RN4 are the most commonly used acupoints in treating PMS. However, large-scale, case-control studies with rigorous designs are required to provide more accurate evidence. PMID: 31341497 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - July 27, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Potential Association of Body Constitution with the Prognosis of IgA Nephropathy: A Long-Time Follow-Up of 203 Cases in China.
This study investigated the association between body constitution (BC) and the prognosis of IgA nephropathy. Methods: We analyzed 203 biopsy-diagnosed IgA nephropathy patients, who were followed up for (63.9±16.2) months. The participants' BC statuses were evaluated with the Constitution in Chinese Medicine Questionnaire; the relationships between clinical parameters and renal outcomes were analyzed by Cox regression. Results: Patients were classified into chronic kidney disease stages with 43.4% in stage 1, 27.1% in stage 2, 26.1% in stage 3, 3.5% in stage 4, and none in stage 5. Qi-deficiency BC type was t...
Source: Evidence-based Complementary and Alternative Medicine - July 27, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Acupuncture Point "Hegu" (LI4) Is Close to the Vascular Branch from the Superficial Branch of the Radial Nerve.
Acupuncture Point "Hegu" (LI4) Is Close to the Vascular Branch from the Superficial Branch of the Radial Nerve. Evid Based Complement Alternat Med. 2019;2019:6879076 Authors: Umemoto K, Naito M, Tano K, Terayama H, Koike T, Ohmichi M, Ohmichi Y, Sakabe K, Nakano T Abstract The acupuncture point "Hegu" (LI4) has been used for treating peripheral circulatory failure, which is located in the area covered by the superficial branch of the radial nerve (SBRN). SBRN has branches reaching arteries, so-called vascular branches (VBs), which are thought to be involved in the arterial constrict...
Source: Evidence-based Complementary and Alternative Medicine - July 27, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Safety Concerns of Traditional Chinese Medicine Injections Used in Chinese Children.
Authors: Tan L, Li M, Lin Y Abstract Objective: To explore risks underlying traditional Chinese medicine (TCM) injection-related adverse drug reactions (ADRs) in Chinese children, and to discuss the implications of postmarketing reevaluation studies. Methods: We identified potential cases of exposure to TCM injections for children (
Source: Evidence-based Complementary and Alternative Medicine - July 27, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Cardiac Inotropic Effect of Long-Term Administration of Oral Thymoquinone.
Conclusions: Long-term administration of oral TQ induced a positive inotropic effect in the form of an increase in peak tension. TQ administration did not result in cardiac hypertrophy or an increased cardiac metabolic demand at the studied dose. TQ may be a promising inotropic agent. PMID: 31341501 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - July 27, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Efficacy and Safety of Fire Needle Therapy for Nodular Prurigo: A Quantitative Study.
Authors: Luo Y, Kuai L, Song N, Ding X, Sun X, Luo Y, Ru Y, Hong S, Xing M, Zhou M, Li B, Li X Abstract In this quantitative study, we evaluated the effectiveness and safety of fire needle therapy for nodular prurigo. We systematically searched several databases, including EMBASE, PubMed, the Cochrane Library, the Web of Science, the China Network Knowledge Infrastructure, the Wanfang Data Knowledge Service Platform, and the China Science and Technology Journal Database, and retrieved randomized controlled trials comparing conventional therapies (control group) with fire needle therapy alone or in combination with ...
Source: Evidence-based Complementary and Alternative Medicine - July 27, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Effect of Furostanol Saponins from Allium Macrostemon Bunge Bulbs on Platelet Aggregation Rate and PI3K/Akt Pathway in the Rat Model of Coronary Heart Disease.
Authors: Feng H, Wang Z, Wang C, Zhu X, Liu Z, Liu H, Guo M, Hou Q, Chu Z Abstract Aim. To investigate the effect of Furostanol Saponins from Allium Macrostemon Bunge Bulbs (FSAMB) on platelet aggregation rate of rats with coronary heart disease and discuss the mechanism of FSAMB affecting the platelet aggregation rate through PI3K/Akt pathway. We established the rat models with coronary heart disease (CHD) and prepared the platelet-rich plasma. The effect of different concentrations of FSAMB on platelet aggregation in SD rats induced by ADP was observed in vitro and in vivo. And Lactate Dehydrogenase (LDH), Creati...
Source: Evidence-based Complementary and Alternative Medicine - July 27, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

The Effectiveness of Acupoint Catgut Embedding Therapy for Abdominal Obesity: A Systematic Review and Meta-Analysis.
This study is registered with PROSPERO 2017 (CRD42017082357). PMID: 31341504 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - July 27, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

A Double-Blind, Randomized Controlled 12-Week Follow-Up Trial to Evaluate the Efficacy and Safety of Polycan in Combination with Glucosamine for the Treatment of Knee Osteoarthritis.
Authors: Truong TTT, Lim JM, Cho HR, Kim YS, Dao DG, Tran QH, Choi JS Abstract Aim: The aim of the present study was to examine the efficacy and safety of Polycan, a β-glucan produced from the black yeast Aureobasidium pullulans SM-2001, in combination with glucosamine in reducing knee osteoarthritis-associated symptoms. Methods: This was a double-blind, randomized controlled trial of a formulated product composed of 16.7 mg of Polycan and 250 mg of glucosamine (Group A), 16.7 mg of Polycan and 500 mg of glucosamine (Group B), or 500 mg of glucosamine (control group) per capsule, administered as three caps...
Source: Evidence-based Complementary and Alternative Medicine - July 27, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

LC-ESI-MS/MS Phenolic Profile of Volutaria lippii (L.) Cass. Extracts and Evaluation of Their In Vitro Antioxidant, Antiacetylcholinesterase, Antidiabetic, and Antibacterial Activities.
In this study, five different extracts from Tunisian Volutaria lippii (L.) Cass. were evaluated for their in vitro antioxidant, antiacetylcholinesterase, antidiabetic, and antibacterial activities as well as for their total phenolic and flavonoid contents. The results indicated that the ethyl acetate and aqueous fractions have the highest levels in phenolic and flavonoid contents and showed remarkable antioxidant activities using DPPH (IC50= 11.50±0.57 and 28.81±1.35μg/mL, respectively), total antioxidant capacity (105.21±0.01 and 98.77±0.02 mg vitamin E/g extract, respectively), and reducing...
Source: Evidence-based Complementary and Alternative Medicine - July 27, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Neuroprotective Effects of Musk of Muskrat on Transient Focal Cerebral Ischemia in Rats.
Authors: Lee D, Kim YS, Song J, Kim H Abstract Musk of musk deer has been one of the most precious traditional medicinal materials for treatment of stroke, but trading is prohibited. Musk of muskrat, Ondatra zibethicus, is an accessible substitute for musk of musk deer. However, neuroprotective effects of the musk of muskrat on stroke model are so far unclear. Aim of the study is to determine neuroprotective effects of the musk of muskrat on focal cerebral ischemia. The protective effects against focal cerebral ischemia were evaluated using a model of middle cerebral artery occlusion (90-minute occlusion followed b...
Source: Evidence-based Complementary and Alternative Medicine - July 27, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

A New Flavanone as a Potent Antioxidant Isolated from Chromolaena odorata L. Leaves.
Authors: Putri DA, Fatmawati S Abstract Chromolaena odorata L. (Asteraceae) is one of the tropical plants which is widely used as traditional medicines for diabetes and soft tissue wounds treatment in some regions in East Indonesia. The present study was aimed at determining the bioactive compounds of C. odorata leaves. The methanol and ethyl acetate extracts of C. odorata leaves have the inhibitory activity against 2,2-diphenyl-1-picryl-hydrazyl (DPPH) and 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radicals as well as α-glucosidase rat intestine enzyme. A new flavanone was isolated from th...
Source: Evidence-based Complementary and Alternative Medicine - July 20, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Mechanisms Underlying the Prevention and Treatment of Cholelithiasis Using Traditional Chinese Medicine.
Authors: Chen Q, Zhang Y, Li S, Chen S, Lin X, Li C, Asakawa T Abstract Cholelithiasis is a major public health concern that necessitates highly effective, feasible, and recurrence-preventing therapies. Currently available surgical treatments and medications cannot effectively avoid the recurrence of cholelithiasis. Hence, several Chinese herbal compounds (CHCs) are considered for the treatment of cholelithiasis, considering that they can effectively discharge gallstones and prevent the recurrence of such condition. In the present narrative review, we aim to summarize the underlying mechanisms of currently used CHC...
Source: Evidence-based Complementary and Alternative Medicine - July 20, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Efficacy of Two-Stage Treatment of Onychomycosis Using a Long-Pulsed Nd:YAG 1064-nm Laser.
Conclusion: Long-pulsed Nd:YAG 1064-nm laser two-stage treatment was effective for onychomycosis, with significantly improved mycological clearance and clinical efficacy. This trial is registered with ChiCTR 1900021669. PMID: 31316570 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - July 20, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

An Ancient Chinese Herbal Decoction Containing Angelicae Sinensis Radix, Astragali Radix, Jujuba Fructus, and Zingiberis Rhizoma Recens Stimulates the Browning Conversion of White Adipocyte in Cultured 3T3-L1 Cells.
Conclusion: These findings suggested that the herbal mixture DBT1155 could potentiate the antiobesity functions of ginger, which might have potential therapeutic implications. PMID: 31316571 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - July 20, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

What Is the Appropriate Acupuncture Treatment Schedule for Chronic Pain? Review and Analysis of Randomized Controlled Trials.
Conclusions: The effect of acupuncture varies greatly with the different schedules of acupuncture, so it is necessary to review and choose the appropriate schedule. Although the current work is based on a limited number of trials, the findings suggest that acupuncture has a dose and frequency effect presenting within a certain range, which would have considerable implications for the design and interpretation of clinical trials. More high-quality randomized controlled trials on acupuncture schedule research were needed for providing more definitive evidence. PMID: 31316572 [PubMed] (Source: Evidence-based Complementary...
Source: Evidence-based Complementary and Alternative Medicine - July 20, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Electroacupuncture on ST36 and GB39 Acupoints Inhibits Synovial Angiogenesis via Downregulating HIF-1 α/VEGF Expression in a Rat Model of Adjuvant Arthritis.
Conclusion. EA on ST36 and GB39 acupoints can effectively inhibit synovial angiogenesis in the AA rat model via downregulating HIF-1α/VEGF expression. PMID: 31316573 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - July 20, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Role of the PERK-eIF2 α-CHOP Signaling Pathway in the Effect of Needle Knife Therapy on Knee Joint Chondrocyte Apoptosis.
Role of the PERK-eIF2α-CHOP Signaling Pathway in the Effect of Needle Knife Therapy on Knee Joint Chondrocyte Apoptosis. Evid Based Complement Alternat Med. 2019;2019:7164916 Authors: Yang YH, Liu TH, Zhang LD, Chen ZY, Huang XS Abstract Needle knife therapy, a form of acupuncture and moxibustion, has been widely used in the clinical treatment of knee osteoarthritis (KOA). However, the mechanism is not clear. Therefore, we studied the mechanisms of action of needle knife intervention on KOA in rabbits, with the PERK-eIF2α-CHOP pathway as a starting point, in order to determine the mechanism...
Source: Evidence-based Complementary and Alternative Medicine - July 20, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Corrigendum to "6-Gingerol Protects Heart by Suppressing Myocardial Ischemia/Reperfusion Induced Inflammation via the PI3K/Akt-Dependent Mechanism in Rats".
Corrigendum to "6-Gingerol Protects Heart by Suppressing Myocardial Ischemia/Reperfusion Induced Inflammation via the PI3K/Akt-Dependent Mechanism in Rats". Evid Based Complement Alternat Med. 2019;2019:7659701 Authors: Xu T, Qin G, Jiang W, Zhao Y, Xu Y, Lv X Abstract [This corrects the article DOI: 10.1155/2018/6209679.]. PMID: 31316575 [PubMed - in process] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - July 20, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Herbal Formula Fo Shou San Attenuates Alzheimer's Disease-Related Pathologies via the Gut-Liver-Brain Axis in APP/PS1 Mouse Model of Alzheimer's Disease.
In this study, to identify the differentially gut-liver-brain axis among APP/PS1 mice, FSS-treated APP/PS1 mice, and control mice, behavioral tests were performed to assess the cognitive ability and hematoxylin-eosin staining was used to assess neuronal damage in the hippocampus; immunohistochemistry, western blotting, a quantitative chromogenic end-point Tachypleus amebocyte lysate (TAL) assay kit, Malondialdehyde (MDA) assay kit, AP Assay Kit, and real-time quantitative PCR (qPCR) were used to assess the level of LPS, MDA, AP, and gut bacteria. We found that FSS regulates gut-liver-brain axis to regulate AP and gut bacte...
Source: Evidence-based Complementary and Alternative Medicine - July 20, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Application of a Cloud Model-Set Pair Analysis in Efficacy Assessment for Diabetic Ulcers.
Authors: Kuai L, Xing JQ, Zhang JT, Xu XZ, Wu MF, Zhao KQ, Li B, Li FL Abstract Because treatment of diabetic ulcers includes various uncertainties, efficacy assessments are needed and significant. In previous studies, set pair analysis (SPA) has been applied to the efficacy assessments of traditional Chinese medicine (TCM) that pick out uncertainties related to the development and prognosis of disease. Optimized clinical protocols of SPA improve clinical efficacy. In the article, cloud model (CM) is employed to improve SPA, and a novel efficacy assessment method for a treatment of diabetic ulcers is proposed based...
Source: Evidence-based Complementary and Alternative Medicine - July 20, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Analgesic Effects of Cnidium officinale Extracts on Postoperative, Neuropathic, and Menopausal Pain in Rat Models.
In this study, we reveal that the C. officinale extract (COE) has great efficacy as a novel analgesic in various in vivo pain models. Administration of COE attenuated hypersensitivity in all postoperative, neuropathic, and menopausal pain models. Decreased hyperalgesia was confirmed by a mechanical withdrawal threshold assay and ultrasonic vocalization call analysis. In addition, application of COE inhibited the induction of the proinflammatory cytokines and calpain-3 on dorsal root ganglion neurons in a spared nerve injury rat model. Treatment with ferulic acid, which was identified as one of the components of COE by HPLC...
Source: Evidence-based Complementary and Alternative Medicine - July 20, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Effects of Curcumin on Vessel Formation Insight into the Pro- and Antiangiogenesis of Curcumin.
Authors: Wang TY, Chen JX Abstract Curcumin is a compound extracted from the Curcuma longa L, which possesses a wide range of pharmacological effects. However, few studies have collected scientific evidence on its dual effect on angiogenesis. The present review gathered the fragmented information available in the literature to discuss the dual effect and possible mechanisms of curcumin on angiogenesis. Available information concerning the effect of curcumin on angiogenesis is compiled from scientific databases, including PubMed and Web of Science using the key term (curcumin and angiogenesis). The results were revi...
Source: Evidence-based Complementary and Alternative Medicine - July 20, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Weiqi Decoction Attenuated Chronic Atrophic Gastritis with Precancerous Lesion through Regulating Microcirculation Disturbance and HIF-1 α Signaling Pathway.
Conclusion: WQD attenuated CAG with precancerous lesion through regulating gastric mucosal blood flow disturbance and HIF-1α signaling pathway. PMID: 31320912 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - July 20, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Antioxidant Properties of Unripe Carica papaya Fruit Extract and Its Protective Effects against Endothelial Oxidative Stress.
In conclusion, UCP protected endothelial cells against oxidative damage through intracellular ROS reduction, enhanced CAT activity, suppression of NF-kB, and prohibition of Nrf2 dysregulation. Thus, UCP might be a candidate for development of nutraceuticals against CVD and oxidative-related diseases and conditions. PMID: 31320913 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - July 20, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Traditional Chinese Medicine Preparation Combined Therapy May Improve Chemotherapy Efficacy: A Systematic Review and Meta-Analysis.
Conclusions: Traditional Chinese medicine preparation combined with chemotherapy may improve objective response rates and disease control rates more than chemotherapy alone. The evidence that combined traditional Chinese medicine preparation can reduce the side effects of chemotherapy is insufficient. More rigorous randomized controlled trials are needed to confirm these conclusions. PMID: 31320914 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - July 20, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

The Protective Effect of Sonneratia apetala Fruit Extract on Acetaminophen-Induced Liver Injury in Mice.
Authors: Liu J, Luo D, Wu Y, Gao C, Lin G, Chen J, Wu X, Zhang Q, Cai J, Su Z Abstract Acute liver injury is a common consequence of taking overdose of acetaminophen (APAP). The aim of this study was to evaluate the antioxidant activity and hepatoprotective effect of a mangrove plant Sonneratia apetala fruit extract (SAFE) on APAP-induced liver injury in mice. Mice were orally pretreated with SAFE (100, 200, and 400 mg/kg) daily for one week. The control and APAP groups were intragastrically administered with distilled water, and NAC group was treated with N-Acetyl-L-cysteine (NAC) before APAP exposure. The results...
Source: Evidence-based Complementary and Alternative Medicine - July 20, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Ganji Formulation for Patients with Hepatocellular Carcinoma Who Have Undergone Surgery: A Multicenter, Randomized, Double-Blind, Controlled Trial.
Authors: Zhang JH, Zheng C, Zhu XJ, Zhang X, Hou ZJ, Zhou ZH, Wang YQ, Wang KX, Yu Z, Li M, Gao YQ, Sun XH Abstract Objective. To ascertain the efficacy and safety of Ganji Formulation (GF) for patients with Hepatocellular carcinoma (HCC) who had undergone surgery. Materials and Methods. A total of 262 HCC patients who had undergone liver resection, local ablation, or transcatheter arterial chemoembolization (TACE) were divided randomly into the treatment group and control group. The former was treated with GF and the later with placebo, both for 6 months. The primary endpoint was overall survival (OS). Second endp...
Source: Evidence-based Complementary and Alternative Medicine - July 20, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Effects of Royal Jelly Administration on Lipid Profile, Satiety, Inflammation, and Antioxidant Capacity in Asymptomatic Overweight Adults.
Conclusion: Compared with the placebo, RJ supplementation demonstrated a statistically significant decrease in total cholesterol (6.7%; p=0.041) and inflammatory marker C-reactive protein (19%; p=0.027), whereas significant increases were observed in anti-inflammatory marker adiponectin (34%; p=0.011), endogenous antioxidants bilirubin (35%; p=0.002) and uric acid (5%; p=0.018), total antioxidant capacity in serum (54%; p=0.005), and leptin (17%; p=0.025). The present study demonstrated positive effects of RJ administration on lipid profile, satiety, inflammation, and antioxidant capacity in overweight adults. Therefore, o...
Source: Evidence-based Complementary and Alternative Medicine - July 19, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Cytoprotective Effect of Ligustrum robustum Polyphenol Extract against Hydrogen Peroxide-Induced Oxidative Stress via Nrf2 Signaling Pathway in Caco-2 Cells.
The objective of this study was to assess antioxidative capacity of L. robustum, and its protective effects and mechanisms against hydrogen peroxide (H2O2) - induced toxicity in Caco-2 cells. Total phenolic contents, free radical scavenging activity, and reducing capacity of L. robustum were measured. The effects of L. robustum on the cell viability and antioxidant defense system were explored. The expression of nuclear factor E2 related factor 2 (Nrf2) and antioxidant genes: quinone oxidoreductase 1 (NQO1), heme oxygenase-1 (HO-1), and glutamate cysteine ligase (GCL) were analyzed by western blot and qPCR. Pretreatment of...
Source: Evidence-based Complementary and Alternative Medicine - July 19, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Chinese Herbal Medicines Compared with N-Acetylcysteine for the Treatment of Idiopathic Pulmonary Fibrosis: A Systematic Review of Randomized Controlled Trials.
Conclusions: Some CHMs seem effective and safe as alternative remedies for patients with IPF, suggesting that further study of CHMs in the treatment of IPF is warranted. Although this systematic review suggests that CHMs may have positive effect on quality of life, 6-minute walk test distance, and lung function (TLC, DLOC%) and seem to be relatively safe during the course of treatment, the results must be treated with great caution because of the methodological flaws of the included trials. Long-term and high-quality trials are needed in the future to provide clear evidence for the use of CHMs. PMID: 31312224 [PubMed] ...
Source: Evidence-based Complementary and Alternative Medicine - July 19, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Effectiveness of Laser Acupuncture in Alleviating Chronic Insomnia: A Single-Blinded Randomized Controlled Trial.
Conclusions: For chronic insomnia insomniacs, LLLT appears to shorten the sleep latency, decrease the number of awakening events at night, and improve the sleep efficiency. PMID: 31312225 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - July 19, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

The Anti-Inflammatory Effect of Feiyangchangweiyan Capsule and Its Main Components on Pelvic Inflammatory Disease in Rats via the Regulation of the NF- κB and BAX/BCL-2 Pathway.
In this study, FYC and its main components dramatically suppressed the infiltration of inflammatory cells, reduced the production of IL-1β, TNF-α, and MCP-1, and elevated the IL-10 level to varying degrees. We also found that FYC and its main components inhibited the expression of BAX induced by infection and increased the expression of Bcl-2. FYC, GA, EA, and SY could also block the activation of the NF-κB pathway. Finally, we found that the phosphorylation of JNK could be decreased by FYC, GA, and SY. FYC and its main components exhibit anti-inflammatory effect on a pathogen-induced PID model by regulati...
Source: Evidence-based Complementary and Alternative Medicine - July 19, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

The Role of Herbal Bioactive Components in Mitochondria Function and Cancer Therapy.
Authors: Tao F, Zhang Y, Zhang Z Abstract Mitochondria are highly dynamic double-membrane organelles which play a well-recognized role in ATP production, calcium homeostasis, oxidation-reduction (redox) status, apoptotic cell death, and inflammation. Dysfunction of mitochondria has long been observed in a number of human diseases, including cancer. Targeting mitochondria metabolism in tumors as a cancer therapeutic strategy has attracted much attention for researchers in recent years due to the essential role of mitochondria in cancer cell growth, apoptosis, and progression. On the other hand, a series of studies h...
Source: Evidence-based Complementary and Alternative Medicine - July 17, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

FuFangChangTai Decoction Activates Macrophages via Inducing Autophagy.
Authors: Li L, Wang H, Qian J, Wei G, Ding R, Hu C, Fang D, Jiang Z, Bi L, Song J, Ma J, Qin F, Huang X, Cao M, Huo J Abstract The traditional Chinese medicine decoction FuFangChangTai (FFCT) has been used in the therapy of colon cancer clinically, yielding alleviated toxicity and enhanced immunity. In our previous study, FFCT exerted its antitumor activity not only by inducing apoptosis but also by activating autophagy to eliminate tumor cells. However, its mechanism is not well understood. The purpose of this study was to investigate the relationship between macrophages activation and FFCT-induced autophagy. Resu...
Source: Evidence-based Complementary and Alternative Medicine - July 17, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Effect of Ligustrazine on Endometrium Injury of Thin Endometrium Rats.
Authors: Ye Q, Zhang Y, Fu J, Zou Y, Zhao W, Chen C, Liu K Abstract The purpose of this experiment is to establish a rat model of thin endometrium and to explore the effect of ligustrazine on the thin endometrium of rats. The thin endometrium model was made by using infusing absolute ethyl alcohol into the uterine cavity. The thickness of endometrium was measured. Hematoxylin-Eosin (HE) staining was used to observe the histopathological changes of endometrium. The mRNA levels of VEGF, VEGFR-2, PI3K, and AKT were detected by RT-PCR. Western blotting was used to detect the levels of VEGF, VEGFR-2, PI3K, and AKT in en...
Source: Evidence-based Complementary and Alternative Medicine - July 17, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

The Method of Activating Blood and Dredging Collaterals for Reducing Chemotherapy-Induced Peripheral Neuropathy: A Systematic Review and Meta-Analysis.
Conclusions: The work involving studies of the effectiveness and safety on TCM for reducing CIPN proves to be encouraging. Herbs with the function of activating blood and dredging collaterals were found to potentially promote the curative effects as well as making improvements of SNCV and MNCV. However, in the future, more double-blind, multicenter, large-scale RCTs and more comprehensive researches are still required. PMID: 31281395 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - July 11, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Ursolic Acid Inhibits Epithelial-Mesenchymal Transition through the Axl/NF- κB Pathway in Gastric Cancer Cells.
Conclusion: UA can effectively inhibit the proliferation and migration and induce apoptosis of gastric cancer cells. The antitumor effect of UA is conducted by EMT inhibition, which may be associated with the regulation of Axl/NF-κB signaling pathway. PMID: 31281396 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - July 11, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Acupuncture for Primary Osteoporosis: Evidence, Potential Treatment Prescriptions, and Mechanisms.
In conclusion, our Veritas plots enable acupuncturists to evaluate key attributes of meta-analysis quality related to acupuncture for primary OP and to improve the quality of evidence-based medicine relating to acupuncture. Data mining analysis revealed an association network of meridians, acupoint combinations, core acupoints, and the underlying mechanisms of acupuncture for primary OP. PMID: 31281397 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - July 11, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Studies on Antibacterial Activity and Diversity of Cultivable Actinobacteria Isolated from Mangrove Soil in Futian and Maoweihai of China.
Authors: Li F, Liu S, Lu Q, Zheng H, Osterman IA, Lukyanov DA, Sergiev PV, Dontsova OA, Liu S, Ye J, Huang D, Sun C Abstract Mangrove is a rich and underexploited ecosystem with great microbial diversity for discovery of novel and chemically diverse antimicrobial compounds. The goal of the study was to explore the pharmaceutical actinobacterial resources from mangrove soil and gain insight into the diversity and novelty of cultivable actinobacteria. Consequently, 10 mangrove soil samples were collected from Futian and Maoweihai of China, and the culture-dependent method was employed to obtain actinobacteria. A tota...
Source: Evidence-based Complementary and Alternative Medicine - July 11, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research