Neurodevelopmental outcome at 42 months following thyroxine supplementation in infants below 28 weeks' gestation: a randomised controlled trial.
CONCLUSION Our data suggest that early supplementation with LT4 may improve long-term neurodevelopment in infants born below 28 weeks' gestation but larger trials are warranted as the current reported improvements shown are not strong enough to warrant a change in practice. PMID: 32070246 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - February 21, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Thyroid deficiency before birth alters the adipose transcriptome to promote overgrowth of white adipose tissue and impair thermogenic capacity.
Conclusions Growth and development of adipose tissue before birth is sensitive to thyroid hormone status in utero. Changes to the adipose transcriptome and phenotype observed in the hypothyroid fetus may have consequences for neonatal survival and the risk of obesity and metabolic dysfunction in later life. PMID: 32070265 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - February 21, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Is there a difference between minimal and gross extension into the strap muscles for the risk of recurrence in papillary thyroid carcinomas?
This study aimed at comparing risk of recurrence and response to therapy of PTC with mETE and gross ETE into the strap muscles (gETE) to low- and intermediate-risk PTC without ETE (low w/o ETE and intermediate w/o ETE) to further characterize the impact of ETE on outcomes. METHODS: 596 PTCs were analyzed according to degree of ETE and other predictors of recurrence. Four groups of patients were compared, low w/o ETE (n=251), intermediate w/o ETE (n=89), mETE (n=191) and gETE (n=65), to determine the risk of recurrence and the response to treatment. Cox proportional hazards models were used to investigate associations b...
Source: Thyroid : official journal of the American Thyroid Association - February 17, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Laser Ablation versus Radiofrequency Ablation for benign non-functioning thyroid nodules: Six-month results of a randomised, parallel, open-label, trial (LARA trial).
Authors: Cesareo R, Pacella CM, Pasqualini V, Campagna G, Iozzino M, Gallo A, Lauria Pantano A, Cianni R, Pedone C, Pozzilli P, Taffon C, Crescenzi A, Manfrini S, Palermo A Abstract BACKGROUND: No direct prospective studies comparing laser ablation (LA) and radiofrequency ablation (RFA) for debulking benign non-functioning thyroid nodules (BNTNs) exist. We aimed to compare the efficacy and safety of both techniques in patients with solid or predominantly solid BNTN. METHODS: This six-month, single-use, randomized open label parallel trial compared the following primary endpoints between the RFA and LA groups si...
Source: Thyroid : official journal of the American Thyroid Association - February 15, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Early diagnosis of medullary thyroid cancer: Are calcitonin stimulation tests still indicated in the era of highly sensitive calcitonin immunoassays?
Conclusion Predefined sex-specific bCT cut-off levels are helpful for the early detection of MTC and for predicting lateral neck lymph node metastasis.Ca-sCT did not improve preoperative diagnostics.bCT levels>43pg/ml and>100pg/ml for males and of>23pg/ml and>85pg/ml for females are relevant for advising patients and planning the extent of surgery. PMID: 32056502 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - February 15, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

American Thyroid Association ® Satellite Symposium: Personalized Approach to Thyroid Disorders.
American Thyroid Association® Satellite Symposium: Personalized Approach to Thyroid Disorders. Thyroid. 2020 Feb 14;: Authors: Boucai L, Celi FS Abstract The highlights of the American Thyroid Association® Satellite Symposium: Personalized Approach to Thyroid Disorders held on Friday, March 27, 2020, 1:00 PM - 5:30 PM at the Moscone Convention Center, San Francisco, California are described below. PMID: 32056503 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - February 15, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Shifting Trends and Informed Decision Making in the Management of Graves' Disease.
Authors: Seib CD, Chen J, Iagaru A Abstract Not applicable for invited commentary. PMID: 32046610 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - February 14, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

The APCs of PTCs: Adenomatous Polyposis Syndrome and the Thyroid.
Authors: Yehia L, Eng C Abstract NA. PMID: 32041494 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - February 13, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

A Germline < i > CHEK2 < /i > Mutation in a Family with Papillary Thyroid Cancer.
A Germline CHEK2 Mutation in a Family with Papillary Thyroid Cancer. Thyroid. 2020 Feb 11;: Authors: Zhao Y, Yu T, Chen L, Xie D, Wang F, Fu L, Cheng C, Li Y, Zhu X, Miao G Abstract Approximately 5% of all cases of PTC are inherited. However, the susceptibility gene(s) for nonsyndromic familial papillary thyroid carcinoma (FPTC) remain unclear. We performed whole genome sequencing (WGS) of peripheral-blood DNA samples from two affected family members with PTC. CHEK2 transcript expression and the protein levels of CHK2 and p53 were evaluated in the thyroid tissues from two affected members of the kindre...
Source: Thyroid : official journal of the American Thyroid Association - February 13, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Thyroid carcinomas that occur in familial adenomatous polyposis patients recurrently harbor somatic variants in APC, BRAF, and KTM2D.
CONCLUSIONS: Our data indicate that FAP-associated PTCs typically have distinct mutations compared to sporadic PTCs. Roughly half of the thyroid cancers that arise in FAP patients have somatic "second-hits" in APC, which is associated with PTC-CMV histology. Somatic BRAF p.Val600Glu variants also occur in some FAP patients, a novel finding. We speculate that in carriers of heterozygous pathogenic mutations of tumor suppressor genes such as APC, a cooperating second-hit somatic variant may occur in a different gene such as KTM2D or BRAF, leading to differences in phenotypes. The role of germline variance in genes ...
Source: Thyroid : official journal of the American Thyroid Association - February 8, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Nomogram based on shear-wave elastography radiomics can improve preoperative cervical lymph node staging for papillary thyroid carcinoma.
Conclusion The presented radiomics nomogram, which is based on the SWE radiomics signature, shows favorable predictive value for LN staging in patients with PTC. PMID: 32027225 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - February 8, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Genomic and Transcriptomic Characterization of Sporadic Medullary Thyroid Carcinoma.
Conclusion: In addition to RET, our research also shows there may be high-frequency FAT1/FAT4 genomic alterations in sMTC. Two molecular subtypes of sMTC with distinct biological behaviors are also identified. However, our results need to be validated by larger samples and more comprehensive experiments in the future, especially for the frequency and function of FAT1/FAT4 germline variants. PMID: 32031055 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - February 8, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Title: Commentary on: "Investigating the effect of thyroid nodule location on the risk of thyroid cancer," Jasim et al. Alternate title: Thyroid nodules and real estate: location matters.
Title: Commentary on: "Investigating the effect of thyroid nodule location on the risk of thyroid cancer," Jasim et al. Alternate title: Thyroid nodules and real estate: location matters. Thyroid. 2020 Feb 07;: Authors: Tessler FN Abstract N/A (invited commentary). PMID: 32031059 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - February 8, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Preoperative and postoperative risk stratification of thyroid papillary microcarcinoma. A comparative study between Kuma criteria and 2015 ATA guidelines risk stratification.
Authors: Perez-Soto RH, Velázquez-Fernández D, Arellano-Gutiérrez G, Chapa Ibarguengoitia M, Trolle Silva AM, Iñiguez-Ariza N, Pérez-Enríquez B, Sierra-Salazar M, Pantoja Millán JP, Herrera-Hernández MF Abstract BACKGROUND: Incidence of papillary thyroid microcarcinoma (mPTC) has increased in the last decade. Active surveillance has been proposed as an alternative management for low risk mPTC based on preoperative Kuma criteria. Controversy still exists on how to appropriately manage this group of patients, as some low risk mPTC may harbor some postoperative r...
Source: Thyroid : official journal of the American Thyroid Association - February 8, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

AIBx, artificial intelligence model to risk stratify thyroid nodules.
Conclusion When compared to published results of ultrasound thyroid cancer risk stratification systems, our image similarity model had comparable negative predictive value with better sensitivity specificity and positive predictive value. By using image similarity AI models, we can decrease subjectivity and decrease the number of unnecessary biopsies. Using image similarity AI model, we were able to create an explainable AI model which increases physician's confidence in the predictions. PMID: 32013775 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - February 5, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

The presence of H ürthle cells does not increase the risk of malignancy in most Bethesda categories in thyroid fine-needle aspirates.
CONCLUSION: Although Hürthle cells have been considered by clinicians as an "atypical cell" their presence does not increase the risk of malignancy within BSRTC categories overall. However, when predominant Hürthle cell change is present, the risk of malignancy is increased in the benign cytology/BSRTC category II. PMID: 32013786 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - February 5, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Utilities of RAS mutations in pre-operative fine needle biopsies for decision-making for thyroid nodule management: results from a single-center prospective cohort.
CONCLUSIONS: RAS mutations represent the most frequently detected genetic alterations in our series. RAS mutations, when occurring alone, are not helpful markers to identify malignancy among Bethesda III/IV cytologies, but may predict favorable behavior, and hence should be considered to guide initial management. PMID: 31996097 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - February 1, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Graves' disease and toxic nodular goiter, aggravated by duration of hyperthyroidism, are associated with Alzheimer's and vascular dementia. A register-based long-term follow-up of two large cohorts.
CONCLUSIONS: Using large scale register-based data we found increased risk of dementia in hyperthyroid individuals. Every 6 months of decreased TSH increased risk of dementia by 16%, compared to individuals with normal TSH. Our data support early diagnosis and intervention in hyperthyroidism. PMID: 31984866 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - January 29, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Patient age is an independent risk factor of relapse of differentiated thyroid carcinoma and improves the performance of the ATA stratification system.
CONCLUSIONS: The age threshold adopted in the 8th edition of TNM staging system for DTC patients' prognosis also identifies cases at higher risk of relapse. Applying age at diagnosis, with a cut-off of 55 years, to the ATA risk stratification system identifies cases at highest risk of relapse. PMID: 31973653 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - January 25, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Patterns of use, efficacy and safety of treatment options for patients with Graves' disease: A Nationwide Population-Based Study.
Conclusions ATD therapy was the most common GD therapy and demonstrated the lowest efficacy and infrequent significant adverse effect profile. With one fourth of patients remaining on ATD treatment (initial or second modality treatment), it becomes imperative to determine the long-term efficacy, safety, costs, and burdens of this modality of treatment. PMID: 31973681 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - January 25, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Decision-analytic Modeling Studies in Prevention and Treatment of Iodine Deficiency Disorders and Thyroid Disorders: a Systematic Overview.
Conclusions deriving from these studies, for example that prevention is cost saving, need to be carefully interpreted as they rely on many assumptions. PMID: 31964247 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - January 24, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Evaluation of iodine nutritional status among pregnant women in China: the National Nutrition and Health Survey.
Authors: Yang L, Li M, Liu X, Wu M, Zhang J, Zhao L, Ding G, Yang X Abstract BACKGROUND: Remarkable achievements have been made for over two decades by implementing a universal salt iodization policy in China. However, changes in the standards and manufacturing of iodized salt have made it necessary to regularly monitor iodine intake and thyroid function in the population. Therefore, we aimed to evaluate iodine nutritional status using thyroid function and urinary iodine levels in pregnant women via a national survey. METHODS: Participants included pregnant women enrolled in the 2015 National Nutrition and Heal...
Source: Thyroid : official journal of the American Thyroid Association - January 24, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Letter to the editor: Treatment decisions in thyroid microcarcinomas: Identifying gaps in knowledge to empower our patients.
Authors: Gonzalez-Velazquez CD, O'Malley QF, Yue LE, Urken ML Abstract . PMID: 31964277 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - January 24, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Prognostic value of pre-ablation stimulated thyroglobulin in children and adolescents with differentiated thyroid cancer.
CONCLUSIONS: Our findings suggest that pre-ablation s-Tg has the capability of predicting the clinical outcomes in children and adolescents with thyroid cancer. PMID: 31964278 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - January 24, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Long term declines of thyroid cancer mortality: an international age-period-cohort analysis.
CONCLUSIONS: Global long-term declines in TC mortality have been accompanied by downward trends in both period and cohort effects. Our results suggest lack of evidence of a possible major contribution of "real" risk factors in TC mortality, and indirectly confirm the main role of overdiagnosis in the epidemic of TC incidence. PMID: 31964280 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - January 24, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

< b > Recombinant human thyrotropin worsens renal cortical perfusion and renal function in patients after total thyroidectomy due to differentiated thyroid cancer < /b > .
Conclusions This study indicates that TSH alone, independent of thyroid hormone concentrations, can influence renal perfusion and renal function. PMID: 31964314 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - January 24, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Incidentally discovered papillary thyroid microcarcinomas are more frequently found in patients with chronic lymphocytic thyroiditis than with multinodular goiter or Graves disease.
Authors: Paparodis R, Karvounis E, Bantouna D, Chourpiliadis C, Chourpiliadi H, Livadas S, Imam S, Jaume JC Abstract BACKGROUND: Incidental finding of differentiated thyroid microcarcinomas (DTMc) in patients undergoing thyroid surgery for benign indications, has become increasingly common. Even though carcinogenesis might relate to the background disease of the gland, the incidence of DTMc in the setting of various thyroid disorders remains unclear. We designed the present study to address this question. METHODS: We reviewed data from two prospectively collected databases of consecutive patients undergoing thy...
Source: Thyroid : official journal of the American Thyroid Association - January 19, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

< b > Non-Diagnostic Fine-Needle Aspiration Biopsy of Thyroid Nodules: Outcomes and Determinants < /b > .
Conclusion: Following an initial non-diagnostic FNAB, the probability of yielding a diagnostic result declines with each sequential repeat FNAB. Nonetheless, a tangible possibility of malignancy remains even after repeated non-diagnostic FNABs.  . PMID: 31950884 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - January 19, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Experience with active surveillance of thyroid microcarcinomalow-risk carcinoma in a developing country.
Conclusions: Active surveillance is possible in developing western countries with similar results to those provided by Asian and American authors. PMID: 31950887 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - January 19, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Aspirin use is not associated with lower thyroid cancer risk: A nationwide nested case-control study.
Authors: Lee YK, Hwangbo Y, Lee S, Lee DE, Lee EK, Yeom MS, Joo J, Kong SY Abstract Background While aspirin use is known to be associated with reduced incidence of various cancer types, it is unclear if this benefit extends to thyroid cancer. We aimed to evaluate the association between aspirin use and thyroid cancer development. Methods This nested case-control study used nationwide data from the Korean National Health Insurance Service-National Sample Cohort 2002-2015. In total, 4,547 individuals with newly developed thyroid cancer were matched with 13,641 controls based on age, sex, and follow-up period. Odds r...
Source: Thyroid : official journal of the American Thyroid Association - January 19, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Thyroid disorders and in vitro outcomes of assisted reproductive technology: an unfortunate combination?
Authors: Poppe K, Autin C, Veltri F, Sitoris G, Kleynen P, Praet JP, Rozenberg S Abstract BACKGROUND: The impact of thyroid disorders on in vitro outcomes of assisted reproductive technology (ART) remains controversial. Therefore, the aim of our study was to investigate whether thyroid antibodies (TPO-abs)/thyroid autoimmunity (TAI) or thyroid function (serum TSH)/subclinical hypothyroidism (SCH) are associated with an altered number of oocytes retrieval (NOR), fertilization rate (FR), and embryo quality (EQ). METHODS: Cross-sectional study in 279 women in a single center, comprising 297 cycles and 1168 embryos...
Source: Thyroid : official journal of the American Thyroid Association - January 19, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Inter- and Intra-Observer Agreement in the Assessment of Thyroid Nodule Ultrasound Features and Classification systems: A Blinded Multicenter Study.
CONCLUSIONS: Intra-observer reproducibility for thyroid nodule US reporting and US classification systems appears fairly adequate while the inter-observer agreement between different centers is lower than that assessed in single-center trials. Reporting and rating ability of thyroid US examiners still appear not consistent. An unified lexicon of thyroid US features, a simplified method of classification, and a dedicated training in the description of thyroid US findings may increase the observers' agreement and the predictive value of US classification systems in real world practice. PMID: 31952456 [PubMed - as supplie...
Source: Thyroid : official journal of the American Thyroid Association - January 19, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Generation of novel genetic models to dissect resistance to thyroid hormone receptor alpha in zebrafish.
CONCLUSIONS: The thra duplicated genes are essential to control temporal coordination in post-larva growth and development in a tissue-specific manner. We uncovered novel functions of the duplicated thra genes in zebrafish in development. These mutant zebrafish could be used as a model for further analysis of TR1 mutant actions and for rapid screening of therapeutics for RTH. PMID: 31952464 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - January 19, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

A novel tyrosine kinase inhibitor can augment radioactive iodine uptake through endogenous sodium/iodide symporter (NIS) expression in anaplastic thyroid cancer.
Conclusions CTOM-DHP, a new TKI identified in this study, enhances endogenous NIS expression and thereby is a promising compound for restoring RAI avidity in ATC. PMID: 31928162 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - January 15, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Impact of thyroid autoimmunity on ovarian reserve, pregnancy outcome, and offspring health in euthyroid women following in vitro fertilization/intracytoplasmic sperm injection.
CONCLUSIONS: TAI had no impact on ovarian reserve in euthyroid women and had no association with IVF/ICSI outcomes in women with DOR. Although an increased incidence of congenital anomalies in the positive TAI group was observed in women with NOR, the association between neonatal anomalies and TAI cannot be concluded. Large cohort studies to evaluate the effects of TAI on offspring health are warranted, and further experimental studies are required to explore the underlying mechanisms. PMID: 31928166 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - January 15, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Longitudinal Analysis of the Effect of Radioiodine Therapy on Ovarian Reserve in Females with Differentiated Thyroid Cancer.
Authors: van Velsen EFS, Visser WE, van den Berg S, Kam BLR, van Ginhoven TM, Massolt ET, Peeters RP Abstract Background Although international guidelines have become more conservative on the use of radioactive iodine (RAI) therapy, it is still one of the cornerstones of the treatment of patients with advanced differentiated thyroid cancer (DTC). As a large proportion of females diagnosed with DTC is in their reproductive years, knowledge about the effect of RAI on their gonadal and reproductive function is important. Earlier studies evaluating Anti-Müllerian hormone (AMH) as a representative of ovarian reserv...
Source: Thyroid : official journal of the American Thyroid Association - January 15, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

The characteristics of patients with Graves' disease whose thyroid hormone level increases after substituting potassium iodide for methimazole in the first trimester of pregnancy.
CONCLUSION: It must be borne in mind that a certain proportion of GD patients escape from the antithyroid effect of iodide, and thus that careful follow up is necessary after switching a pregnant patient's medication to KI. PMID: 31928169 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - January 15, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Current iodine nutrition status and prevalence of thyroid disorders in Tibetan adults in an oxygen-deficient plateau, Tibet, China: A Population Based Study.
Authors: Ning P, Ren Q, Zhang Z, Lv X, Meng S, Zeding Z, Zhou L, Luo Y, Yang L Abstract Background Iodine deficiency is a global problem in individuals living in an iodine-deficient environment, specifically in mountainous regions. However, data regarding the iodine nutritional status of Tibetan people in the plateau are limited. Methods A population-based survey was conducted from July 2016 to July 2017 in Lhasa, Tibet, including 12 communities in Lhasa city, and 10 surrounding rural areas. The iodine nutritional status of Tibetan people was evaluated using the traditional iodine nutrition indexes: urinary iodine ...
Source: Thyroid : official journal of the American Thyroid Association - January 15, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

A truncating germline mutation of TINF2 in individuals with thyroid cancer or melanoma results in longer telomeres.
CONCLUSIONS: The rare frameshift mutation in the TINF2 gene and the associated longer telomere length suggest that dysregulated telomeres could be a mechanism predisposing to PTC and melanoma. DNA coding variants in shelterin genes are rare. Further studies are required to evaluate the roles of variants in shelterin genes in thyroid cancer and melanoma. PMID: 31928178 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - January 15, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Shorter recall period for the thyroid-related patient-reported outcome measure ThyPRO did not change the accuracy as evaluated by repeated momentary measurements.
Conclusions Shortening the recall period of ThyPRO from four to one week was not associated with less recall bias within this subset of items. Nor did 1-week recall seem to compromise the accuracy of ThyPRO. Thus, either version of ThyPRO can be used in future studies. PMID: 31928182 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - January 15, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Response to Therapy Assessment in Intermediate-Risk Thyroid Cancer Patients- Is rhTSH Stimulation Required?
CONCLUSIONS: In patients with no evidence of disease during the first 2 years of follow-up, the addition of stimulated-Tg adds little prognostic information. We suggest the use of excellent response to therapy based on basal Tg together with TxWBS and structural imaging studies. PMID: 31928205 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - January 15, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Breast Cancer Risk in Postmenopausal Women with Medical History of Thyroid Disorder in the Women's Health Initiative.
CONCLUSIONS: Compared to women with no history of thyroid disorder, hypothyroidism was associated with a lower risk of breast cancer. This was mainly seen among those who received thyroid replacement therapy and had never used menopausal hormone therapy. Among the treatment options for hypothyroidism, levothyroxine had the strongest inverse association with breast cancer risk. PMID: 31918623 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - January 12, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Lenvatinib for radioactive iodine-refractory differentiated thyroid carcinoma and candidate biomarkers associated with survival: A multicenter study in Korea.
CONCLUSIONS: Our results indicate that reduced doses of lenvatinib triggered by emergent AEs did not abrogate its apparent efficacy in patients with RAI-refractory DTCs. Rather, the sustained use of reduced doses of lenvatinib with a low rate of severe AEs may have contributed to the competent outcomes. TgDT and TGS can assist in predicting the outcomes in these patients. PMID: 31910091 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - January 9, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

From Overdiagnosis to Overtreatment of Low-risk Thyroid Cancer: A Thematic Analysis of Attitudes and Beliefs of Endocrinologists, Surgeons, and Patients.
Authors: Jensen CB, Saucke MC, Francis DO, Voils CI, Pitt SC Abstract INTRODUCTION: The optimal management for patients with small, low-risk thyroid cancer is often debated. We aimed to characterize the attitudes and beliefs of providers and patients about management of small, low-risk thyroid cancer and how they relate to overtreatment. METHODS: We conducted 34 semi-structured interviews with surgeons (n=12), endocrinologists (n=12), and patients with
Source: Thyroid : official journal of the American Thyroid Association - January 9, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

No dataset left behind: mechanistic insights into thyroid receptor signaling through transcriptomic consensome meta-analysis.
CONCLUSIONS: The mouse TR datasets and consensome are freely available in the Signaling Pathways Project website for hypothesis generation, data validation and modeling of novel mechanisms of TR regulation of gene expression. Our results demonstrate the insights into the mechanistic basis of thyroid hormone action that can arise from an ongoing commitment on the part of the research community to the deposition of discovery-scale datasets. PMID: 31910096 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - January 9, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Thyroid function and the risk of fibrosis of the liver, heart and lung in humans: A systematic review and meta-analysis.
Conclusions This study suggests that low thyroid function is associated with increased likelihood of chronic fibrotic diseases of the liver, heart, and lung. However, the evidence is mainly based on cross-sectional data. Prospective studies and randomized clinical trials are needed to investigate the potential efficacy of thyroid hormone and its analogues on the occurrence and progression of fibrosis. PMID: 31910097 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - January 9, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Patients' view on the management of papillary thyroid microcarcinoma: active surveillance or surgery.
CONCLUSION: State anxiety among patients with PTMC seemed to be a reflection of an individual's trait rather than management. Understanding the patients' view appears to be key to improve shared-decision making. PMID: 31910100 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - January 9, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Effects of supplemental vitamin D on muscle performance and quality of life in Graves' disease. A randomized clinical trial.
Authors: Grove-Laugesen D, Cramon PK, Malmstroem S, Ebbehoj E, Watt T, Hansen KW, Rejnmark L Abstract Background Vitamin D deficiency has been proposed a role in development and course of Graves' disease (GD). Muscle weakness and quality of life (QoL) impairments are shared features of GD and vitamin D deficiency. We aimed to investigate whether vitamin D supplementation would improve restoration of muscle performance and thyroid-related QoL in GD and to describe the effect of anti-thyroid medication (ATD) on these outcomes. Methods. In a double-blinded clinical trial, hyperthyroid patients with a first time diagno...
Source: Thyroid : official journal of the American Thyroid Association - January 9, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Investigating the effect of thyroid nodule location on the risk of thyroid cancer.
Authors: Jasim S, Baranski T, Teefey S, Middleton WD Abstract BACKGROUND: Thyroid nodules are routinely evaluated with ultrasound. Our aim was to determine if thyroid nodule location was a useful feature to predict thyroid cancer Methods: Retrospective review of patients with thyroid nodules from six referral centers during 2006 to 2010. A total of 3313 adult patients included with thyroid nodules and confirmed benign or malignant thyroid diagnoses Results: Mean patient age was 54.2 (18-97) years, women (n= 2635, 79.8%). A total of 3241 nodules were analyzed, 335 (10.3%) of which were malignant. Thyroid nodule loca...
Source: Thyroid : official journal of the American Thyroid Association - January 9, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Non-autoimmune hyperthyroidism caused by a somatic mosaic GNAS gene mutation involving part of the thyroid gland.
Authors: Franca MM, Levine RL, Pappa T, Ilaka-Chibuluzo S, Rothberger GD, Dumitrescu AM, Refetoff S Abstract Non-autoimmune hyperthyroidism caused by activating mutations in the GNAS gene is a rare condition. Here we report a 5-year-old girl diagnosed with non-autoimmune hyperthyroidism and tall stature harboring a somatic mosaic gain-of-function mutation in the GNAS gene (NM_080425.3: c.2530C>T;p.Arg844Cys previously reported as NM_000516.5:c.601C>T;p.Arg201Cys) and referred thereafter as R201C, in three of four quadrants of the thyroid gland. Provision of a molecular diagnosis may avoid unnecessary complete...
Source: Thyroid : official journal of the American Thyroid Association - January 9, 2020 Category: Endocrinology Tags: Thyroid Source Type: research