Quantification of global ocular motility impairment in graves' orbitopathy by measuring eye muscle ductions.
QUANTIFICATION OF GLOBAL OCULAR MOTILITY IMPAIRMENT IN GRAVES' ORBITOPATHY BY MEASURING EYE MUSCLE DUCTIONS. Thyroid. 2020 Sep 17;: Authors: Campi I, Currò N, Vannucchi G, Covelli D, Simonetta S, Fugazzola L, Pignataro L, Dazzi D, Guastella C, Lazzaroni E, Pirola G, Salvi M Abstract BACKGROUND: The overall changes of ocular motility in Graves' Orbitopathy (GO), are not easily quantifiable with the methods currently available, especially in clinical studies. The aim of the present study was to calculate parameters that quantify the changes of ocular motility in GO, in relation to the Gorman score...
Source: Thyroid : official journal of the American Thyroid Association - September 19, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

The transcription factor NF- κB mediates thyrotropin-stimulated expression of thyroid differentiation markers.
CONCLUSIONS: Taken together, our results point to NF-κB being a pivotal mediator in the TSH-induced thyroid follicular cell differentiation, a relevant finding with potential physiological and pathophysiological implications. . PMID: 32935630 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - September 18, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Generation and Characterization of a New Resistance to Thyroid Hormone Mouse Model with Thyroid Hormone Receptor Alpha Gene Mutation.
Conclusions The Thrα1E403X/+ mice faithfully recapitulate clinical features of human RTHα, and thus can provide a useful tool to dissect the role of TRα1 in development and to determine the pathological mechanisms of RTHα. PMID: 32924834 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - September 16, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Donafenib in progressive locally advanced or metastatic radioactive iodine-refractory differentiated thyroid cancer: results of a randomized, multicenter, phase II trial.
Conclusion: Donafenib was generally well tolerated. Both donafenib regimens demonstrated similar efficacy in terms of the ORR in locally advanced or metastatic RAIR-DTC. The results warrant further studies on donafenib as a new feasible treatment option for RAIR-DTC patients. PMID: 32907500 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - September 12, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Safety and quality of life data from an Italian expanded access program of lenvatinib for treatment of thyroid cancer.
CONCLUSIONS: The safety profile of the drug was similar to that already reported with some differences in the prevalence and severity of the AEs. Regarding the QoL, the EAP showed a trend of improvement of the general health status and a reduction of symptoms correlated to the disease. The clinical impact of fatigue, anorexia/weight loss and stomatitis, mainly due to the drug itself, continues to represent the major issue in the management of these patients. PMID: 32907501 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - September 12, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Hashimoto's thyroiditis induces hippocampus-dependent cognitive alterations by impairing astrocytes in euthyroid mice.
CONCLUSION: HT can induce damage of LTP in hippocampal Schaffer collateral-CA1 pathway in the euthyroid state and this can be attributed, at least partly, to astrocytes impairment, which may underlie the deleterious effects of HT itself on hippocampal-dependent learning and memory function. PMID: 32907517 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - September 12, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Birth Characteristics and Risk of Pediatric Thyroid Cancer: A Population-Based Record-Linkage Study in California.
CONCLUSIONS: In this first population-based study of birth characteristics and pediatric thyroid cancer, we identified several important risk factors for pediatric thyroid cancer, including female sex, Hispanic ethnicity, higher birth weight, higher maternal educational attainment, and lower birth order. We provide new areas for replication and investigation of biological mechanisms for this poorly understood malignancy. PMID: 32912083 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - September 12, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Barriers against Prevention Programs for Iodine Deficiency Disorders in Europe - A Delphi Study.
CONCLUSION: In our study, we derived key information and first insights with regard to barriers against IDD prevention programs from a broad range of stakeholders. Most barriers were found in the category of implementation and management. Also a lack of political support seems to play an important role. The findings of our study may help decision makers in health policy to develop more effective IDD prevention and monitoring strategies. PMID: 32912084 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - September 12, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Future Meetings.
Authors: PMID: 32916081 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - September 12, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Challenges in Developing Recommendations based on Low Quality Evidence in Thyroid Guidelines.
Authors: Sawka AM, Alexander EK, Bianco AC, Chou R, Haugen B, Kopp PA, Pearce EN, Ross DS, Smallridge RC, Jonklaas J Abstract Not applicable (editorial). PMID: 32900277 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - September 11, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Respone to "Clinical parameters are more likely to be associated with thyroid hormone levels than with thyrotropin levels: A systematic review and meta-analysis".
Respone to "Clinical parameters are more likely to be associated with thyroid hormone levels than with thyrotropin levels: A systematic review and meta-analysis". Thyroid. 2020 Aug 28;: Authors: Hoermann R, Midgley JE, Larisch R, Dietrich JW Abstract A recent debate has evaluated the primary test schema for assessing thyroid function, direct measurement of thyroid hormones or the pituitary hormone TSH. PMID: 32854594 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - August 30, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Benefits and Harms of a Prevention Program for Iodine Deficiency Disorders - Predictions of the Decision-Analytic EUthyroid Model.
CONCLUSION: IDD prevention via mandatory iodine fortification of salt increases quality-adjusted life expectancy in a European population with moderate ID, and is therefore beneficial on a population level. However, further ethical aspects should be considered before implementing a mandatory IDD prevention program. Costs for IDDs prevention and treatment should be included in the decision analysis to evaluate the cost effectiveness of IDD prevention. PMID: 32847437 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - August 29, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Clinically Significant Hyperthyroidism and Hypothyroidism Following Exposure to Compounded Thyroid Products.
Authors: Kim J, Konkel K, Diak IL, Glueck S, McCulley L Abstract Not applicable. PMID: 32838690 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - August 27, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Financial hardship among Hispanic women with thyroid cancer.
CONCLUSIONS: Our findings suggest that across all age groups, low-acculturated Hispanic women with thyroid cancer are vulnerable to financial hardship, emphasizing the need for tailored, patient-focused interventions. PMID: 32838705 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - August 27, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Treatment of subclinical hyperthyroidism in the elderly: Comparison of radioiodine and long-term methimazole treatment.
This study aimed to compare the effectiveness and safety of radioiodine (RAI) and long-term methimazole (MMI) in the treatment of subclinical hyperthyroidism in the elderly. METHODS: From 306 patients, aged ≥ 65 years, with subclinical hyperthyroidism, 83 patients with TSH
Source: Thyroid : official journal of the American Thyroid Association - August 20, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Changes in Population-Level and Institutional-Level Prescribing Habits of Radioiodine Therapy for Papillary Thyroid Cancer.
Authors: Jacobs D, Breen CT, Pucar D, Holt E, Judson BL, Mehra S Abstract BACKGROUND: In the past two decades, new evidence and guidelines have emerged to refine recommendations for the use of radioiodine (RAI) therapy after thyroidectomy for cancer. We aim to describe national trends in RAI utilization, assess the impact of individual hospitals on RAI utilization, and examine whether variation in prescribing habits has declined over time. METHODS: The National Cancer Database (NCDB) was queried from 2004-2016 for patients with papillary thyroid cancer (PTC) who received total thyroidectomy. Trends were analyze...
Source: Thyroid : official journal of the American Thyroid Association - August 20, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

The Intrinsic Activity of Thyroxine is Critical for Survival and Growth and Regulates Gene expression in Neonatal Liver.
CONCLUSION: T4 has intrinsic activity in vivo and is critical for survival and growth. At a physiological level, T4 per se can up- or down-regulate many T3 target genes in the neonatal liver. While most of these genes are also regulated by T3, subsets respond exclusively to T4 or demonstrate enhanced or normalized expression only in the presence of both hormones. These studies demonstrate for the first time a complex dependency on both T4 and T3 for normal mammalian growth and development. PMID: 32791885 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - August 16, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Metformin reduces thyroid cancer tumor growth in the metastatic niche of bone by inhibiting osteoblastic RANKL productions.
Conclusions In the microenvironment of BM, metformin effectively reduced ATC tumor growth by inhibiting cancer cell viability, blocking cancer cell induced osteoblastic RANKL production, which further activated osteoclastogenesis, and directly reduced osteoclast differentiation. These multifactorial actions of metformin suggests it has potential therapeutic effects in thyroid cancer BM. PMID: 32791889 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - August 16, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Defending effects of iodide transfer in placental barrier against maternal iodine deficiency.
CONCLUSION: All mechanisms upregulating the expression of iodine transporters and changes in villous stroma and microvessel area in the placental labyrinth can promote iodide transfer from mother to fetus in iodine deficiency, especially before the onset of fetal thyroid function. Compensatory NIS protein regulation in the placenta against decreased iodine intake mainly occurs during translation and glycosylation modification after translation. Pendrin may be more important than NIS in the mediation of placental iodide transport. PMID: 32791891 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of ...
Source: Thyroid : official journal of the American Thyroid Association - August 16, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

A Type 2 Deiodinase-Dependent Increase in Vegfa Mediates Myoblast-Endothelial Cell Crosstalk During Skeletal Muscle Regeneration.
CONCLUSION: Dio2 loss in the muscle stem cell impairs muscle stem cell-endothelial cell crosstalk via changes in the T3-responsive gene Vegfa, leading to downstream impairment of endothelial cell function in vitro and in vivo. PMID: 32787533 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - August 15, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Thyroid function test abnormalities in twin pregnancies.
Authors: Chen Z, Yang X, Zhang C, Ding Z, Zhang Y, Korevaar T, Fan J Abstract BACKGROUND: As compared to singletons, a twin pregnancy is associated with a larger thyroid hormone demand and an increased stimulation of gestational thyroid function due to higher concentrations of human chorionic gonadotropin (hCG). However, such effects have been sparsely quantified. The aim of this study was to evaluate thyroid function and thyroid function test abnormalities in twin pregnancies during early and late pregnancy as compared to singletons. METHODS: We included 1,208 twin pregnancies and 46,834 singleton pregnancies ...
Source: Thyroid : official journal of the American Thyroid Association - August 13, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Variation in normal range thyroid function affects serum cholesterol levels, blood pressure and type 2 diabetes risk: A Mendelian randomization study.
CONCLUSIONS: Variation in normal range thyroid function affects serum cholesterol levels, blood pressure and T2D risk. PMID: 32746749 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - August 13, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Prenatal treatment of thyroid hormone cell membrane transport defect caused by MCT8 gene mutation.
CONCLUSIONS: This is the first demonstration that prenatal treatment improved the neuromotor and neurocognitive function in MCT8 deficiency. Earlier treatment with TH analogues that concentrate in fetus when given to the mother may further rescue the phenotype. PMID: 32746752 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - August 13, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Urinary iodine and genetic predisposition to Hashimoto's thyroiditis in a Chinese Han population: A case-control study.
CONCLUSIONS: Higher urinary iodine concentration was associated with increased risk of HT, and this association was near linear, indicating that increased urinary iodine has a continuous and graded impact on HT risk. Moreover, the iodine-HT association was not modified by genetic predisposition to HT. Interestingly, urinary iodine concentration was significantly associated with increased risk of hypothyroidism. PMID: 32746755 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - August 13, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Effects of two weekly servings of cod for 16 weeks in pregnancy on maternal iodine status and infant neurodevelopment: Mommy's Food, a randomized controlled trial.
Conclusions Increased cod intake during pregnancy improved the iodine status in women with mild-to-moderate iodine deficiency, however, did not affect thyroid function. The negative effect on cognition should be followed up to assess whether this is a stable effect over time. More studies are warranted to enable good health advice on iodine nutrition in pregnancy. PMID: 32746774 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - August 13, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Thyroid hormone receptor α mutations cause heart defects in zebrafish.
CONCLUSIONS: Using a zebrafish model of RTHalpha, the present studies demonstrated for the first time that TRalpha mutants could act to cause abnormal heart structure, weaken contractility and disrupt sarcomere organization that affect heart functions. These findings provide new insights into the bradycardia found in RTHalpha patients. PMID: 32762296 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - August 13, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Serine 897 phosphorylation of EPHA2 is involved in signaling of oncogenic ERK1/2 drivers in thyroid cancer cells.
CONCLUSIONS: These findings point to EPHA2 S897 as a crucial mediator of the oncogenic activity of the ERK1/2 signaling cascade in thyroid cancer. PMID: 32762307 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - August 13, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

The effect of increased iodine intake on serum thyrotropin: A cross-sectional, Chinese nationwide study.
Authors: Zhao L, Teng D, Shi X, Li Y, Ba J, Chen B, Du J, He L, Lai X, Li Y, Chi H, Liu C, Liu L, Qin G, Qin Y, Quan H, Shi B, Sun H, Tang X, Tong N, Wang G, Zhang JA, Wang Y, Xue Y, Yan L, Yang J, Yang L, Yao Y, Ye Z, Zhang Q, Zhang L, Zhu J, Zhu M, Shan Z, Teng W Abstract BACKGROUND: Subclinical hypothyroidism (SCH) is diagnosed based on serum thyroid-stimulating hormone (TSH) reference intervals, which in turn are affected by many factors. METHODS: Data were acquired from a Chinese nationally representative cross- sectional study of 78,470 participants (TIDE study). The total study population were participan...
Source: Thyroid : official journal of the American Thyroid Association - August 13, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

HIF-1 α-mediated TERT Activation Inducing Autophagy through mTOR Promotes Papillary Thyroid Carcinoma Progression During Hypoxia Stress.
Conclusions We identified a novel molecular mechanism involving the HIF-1α/TERT axis, which promoted PTC progression by inducing autophagy through mTOR during hypoxia stress. These findings may provide a basis for the new treatment of aggressive PTCs. PMID: 32772829 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - August 13, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Non-surgical thermal ablation of thyroid nodules. Not if, but why, when, and how?
Authors: Hegedus L, Miyauchi A, Tuttle RM Abstract Editorial do not have an abstract. PMID: 32777983 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - August 13, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Enhanced canonical Wnt signaling during early zebrafish development perturbs the interaction of cardiac mesoderm and pharyngeal endoderm and causes thyroid specification defects.
CONCLUSION: Collectively, our results indicate that BMP signaling is critically required for thyroid cell specification and identify cardiac mesoderm as a likely source of BMP signals. This article was deposited as a preprint in bioRxiv, p. 2019.12.19.880815, Dec. 2019. PMID: 32777984 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - August 13, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Real world efficacy and safety of cabozantinib and vandetanib in advanced medullary thyroid cancer.
CONCLUSION: Vandetanib and cabozantinib are effective treatment options in the majority of MTC-patients. We hypothesize that the poorer prognosis of cabozantinib-treated patients in our retrospective analysis is most likely due to its use as second line treatment after treatment failure on vandetanib. However, different degrees of efficacy of the two drugs are possible. PMID: 32781914 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - August 13, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

A Comparative Analysis of Two Machine Learning-based Diagnostic Patterns with ACR TI-RADS for Thyroid Nodules: Diagnostic Performance and Unnecessary Biopsy Rate.
CONCLUSION: The ML-assisted dual modalities visual approach can assist radiologists to diagnose thyroid nodules more effectively and considerably reduce the unnecessary FNAB rate in the clinical management of thyroid nodules. PMID: 32781915 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - August 13, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Iodine Deficiency and Mortality in Spanish Adults. Di@bet.es study.
Authors: Maldonado-Araque C, Valdes S, Badía-Guillén R, Lago-Sampedro A, Colomo N, Garcia-Fuentes E, Gutierrez-Repiso C, Goday-Arno A, Calle-Pascual A, Castaño L, Castell C, Delgado Álvarez E, Menendez Torre E, Franch-Nadal J, Gaztambide S, Girbés J, Chaves FJ, Soriguer F, Rojo-Martinez G Abstract BACKGROUND: Longitudinal data assessing the impact of Iodine deficiency on mortality are scarce. We aimed to study the association between the state of iodine nutrition and the risk of total and cause-specific mortality in a representative sample of the Spanish adult population. METH...
Source: Thyroid : official journal of the American Thyroid Association - August 13, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Influence of dietary habits on oxidative stress markers in hashimoto's thyroiditis.
CONCLUSIONS: The present study suggests a protective effect of low intake of animal foods towards thyroid autoimmunity and a positive influence of such nutritional patterns on redox balance and potentially on oxidative stress-related disorders. PMID: 32729374 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - July 31, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Influence of Short-term Dietary and Therapeutic Iodine Restriction on the Therapeutic Effects of Radioactive Iodine Therapy in Patients with Graves' Disease.
CONCLUSION: This study did not find an association between short-term dietary or therapeutic iodine restriction before RAIT and the therapeutic effects of RAIT in an iodine sufficient area. PMID: 32729394 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - July 31, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Human type 1 Iodothyronine deiodinase (DIO1) mutations cause abnormal thyroid hormone metabolism.
CONCLUSIONS: We report the identification and characterization of two missense DIO1 pathogenic variants identified in families with abnormal thyroid hormone metabolism. This is the first demonstration of inherited D1 deficiency in humans. PMID: 32718224 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - July 30, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Validation of american thyroid association ultrasound risk-adapted approach for repeating cytology in benign thyroid nodules.
CONCLUSIONS: Our results confirm the accuracy of the ATA recommendations in selecting benign nodules for FNAC repetition during the follow-up. An additional cytological evaluation maybe avoided in benign thyroid nodules with low risk US features, regardless of the evidence of growth during the follow-up. While the utility of the routine repeat FNAC in all benign nodules with high risk US features remains to be defined, based on our results, repetition of FNAC seems to be indicated in nodules with evidence of growth during the follow-up. PMID: 32718278 [PubMed - as supplied by publisher] (Source: Thyroid : official jour...
Source: Thyroid : official journal of the American Thyroid Association - July 30, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Symptomatic and asymptomatic biliary disorders during lenvatinib treatment for advanced thyroid cancer is an underestimated problem.
Authors: Agate L, Puleo L, Giani C, Valerio L, Molinaro E, Elisei R Abstract This letter is to confirm and support the data of Nervo et al, recently published on Thyroid journal, and showing a relevant prevalence of biliary disorders in patients affected by advanced thyroid cancer (TC) and treated with lenvima. We also observed a similar prevalence of gallbladder and/or biliary disease in a bigger series of TC treated with lenvima: by combining the Nervo et al. and our data the prevalence of this adverse event is of 16/118 (13.5%) and it seems independent from the starting daily dose. Only few differences have been...
Source: Thyroid : official journal of the American Thyroid Association - July 30, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Consequences of hyperthyroidism and its treatment for bone microarchitecture assessed by high resolution peripheral quantitative computed tomography.
Authors: Nicolaisen P, Obling ML, Winther KH, Hansen SG, Hermann AP, Hegedus L, Bonnema SJ, Brix TH Abstract BACKGROUND: Hyperthyroidism is associated with bone mass reduction and increased fracture risk, but the effects on other important bone parameters have been sparsely examined. Therefore, we investigated bone microarchitecture and estimated bone strength, by high-resolution peripheral quantitative computed tomography (HR-pQCT) in hyperthyroid patients at diagnosis and after being euthyroid for at least one year. METHODS: Two approaches were used: A) a case-control study comparing 61 hyperthyroid women wit...
Source: Thyroid : official journal of the American Thyroid Association - July 29, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Mice hypomorphic for Keap1, a negative regulator of the Nrf2 antioxidant response, show age-dependent diffuse goiter with elevated thyrotropin levels.
Conclusions: Keap1KD mice develop age-dependent diffuse goiter with elevated TSH levels. The precise mechanism accounting for the thyroidal phenotype remains to be elucidated, but it may involve enhanced Tg solubilization and excessive lysosomal Tg degradation. PMID: 32689903 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - July 23, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Molecular determinants of thyroid nodules with indeterminate cytology and ras mutations.
MOLECULAR DETERMINANTS OF THYROID NODULES WITH INDETERMINATE CYTOLOGY AND RAS MUTATIONS. Thyroid. 2020 Jul 21;: Authors: Hernandez-Prera J, Valderrabano P, Creed J, de la Iglesia JV, Slebos R, Centeno BA, Tarasova V, Hallanger-Johnson J, Veloski C, Otto KJ, Wenig BM, Yoder S, Lam C, Park DS, Anderson AR, Raghunand N, Berglund A, Caudell J, Gerke TA, Chung CH Abstract BACKGROUND: RAS gene family mutations are the most prevalent in thyroid nodules with indeterminate cytology and are present in a wide spectrum of histological diagnoses. We evaluated differentially expressed genes and signaling pathways ac...
Source: Thyroid : official journal of the American Thyroid Association - July 23, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Emergence of resistant clones in medullary thyroid cancer may not be rescued by subsequent salvage highly selective RET-inhibitor therapy.
Authors: Bruce JY, Bible KC, Chintakuntlawar A Abstract No abstract. PMID: 32664802 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - July 17, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Marked decrease over time in conversion surgery after active surveillance of low-risk papillary thyroid microcarcinoma.
CONCLUSIONS: Patients with PMC in the second-half group were significantly less likely to undergo conversion surgery than those in the first-half group regardless of the reason. This is probably because data accumulation of favorable outcomes with active surveillance significantly contributed to physicians' confidence and patients' trust and understanding of this disease. We hope that our findings can be useful for institutions that have begun or are trying to begin active surveillance for PMC. PMID: 32664805 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - July 17, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Hyperthyroxinemia and hypercortisolemia due to familial dysalbuminemia.
HYPERTHYROXINEMIA AND HYPERCORTISOLEMIA DUE TO FAMILIAL DYSALBUMINEMIA. Thyroid. 2020 Jul 15;: Authors: Moran C, Seger C, Taylor K, Oddy S, Burling K, Rajanayagam O, Fairall L, McGowan AN, Lyons G, Halsall D, Gurnell M, Schwabe J, Chatterjee VK, Strey C Abstract A 23 year old man and his grandmother with hyperthyroxinemia and hypercortisolemia were heterozygous for an ALB mutation (p. Arg218Pro), known to cause Familial Dysalbuminemic Hyperthyroxinemia (FDH). However, serum free cortisol levels in these individuals were normal and total cortisol concentrations fell markedly following depletion of album...
Source: Thyroid : official journal of the American Thyroid Association - July 17, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Anaplastic Thyroid Cancer Arising from Dyshormonogenetic Goiter: c.3070T > C and Novel c.7070T > C Mutation in the Thyroglobulin Gene.
In this study, we describe anaplastic thyroid cancer in a 46-year-old woman with TD who had two germline thyroglobulin (TG) gene mutation, c.3790T>C (p, Cys1264Arg) in exon 17 and a novel c.7070T>C (p.Leu2357Pro) in exon 41 of the TG gene. Two affected younger sisters were also found to have the same TG mutation but not anaplastic thyroid cancer. Any thyroid nodular lesions that develop in patients with TD should be investigated carefully. PMID: 32633627 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - July 9, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Immune profiling of advanced thyroid cancers using fluorescent multiplex immunohistochemistry.
This study aimed to determine the immune profiles of advanced thyroid cancers using fluorescent multiplex immunohistochemistry (F-MIHC) and multispectral imaging (MSI). METHODS: Twenty-eight tissue samples were collected from 12 patients who had DTC with distant metastasis and from 16 with ATC. The samples were assessed using F-MIHC and MSI with antibodies against the cell surface molecules, cluster of differentiation (CD) 4, CD8, programmed cell death (PD-1), PD ligand 1 (PD-L1), forkhead box protein (Foxp)3, and cytokeratin (CK). The expression of PD-L1 was evaluated using tumor proportion score (TPS) and combined po...
Source: Thyroid : official journal of the American Thyroid Association - July 4, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Response to letter to the editor- J Hennessey re clinical parameters and thyroid hormone levels.
Authors: Fitzgerald SP, Bean NG, Falhammar H Abstract We are grateful to Hennessey (1) for providing the opportunity to further clarify the conclusions and implications of our work (2). These are more radical than Hennessey has indicated. We believe the accumulated theoretical and empiric evidence indicates we should be discussing(a) abandoning the term 'subclinical thyroid dysfunction' and replacing it with 'compensated euthyroidism', (b)the adoption of FT4 levels in place of TSH levels as the first step/screening test for clinical assessment of thyroid function, (c) placing greater importance on the presence of a...
Source: Thyroid : official journal of the American Thyroid Association - July 2, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Thyroid function analysis in 50 patients with COVID-19: a retrospective study.
Authors: Chen M, Zhou W, Xu W Abstract BACKGROUND: Since the outbreak of the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in December 2019, it has affected over 200 countries, areas, or territories in six continents. At present, whether COVID-19 has an effect on thyroid function is unclear. The aim of this study was to evaluate thyroid function in patients with COVID-19. METHODS: Clinical manifestations, laboratory results, and chest computed tomography scans were retrospectively reviewed for 50 patients with laboratory-confirmed COVID-19 without a h...
Source: Thyroid : official journal of the American Thyroid Association - July 2, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Paternal subclinical hypothyroidism affects the clinical outcomes of in vitro fertilization/intracytoplasmic sperm injection.
Authors: Rao M, Yang Z, Su C, Zhao Z, Wan R, Liu J, Yao Y, Su Z, Wang K, Tang L, Zhao S Abstract BACKGROUND: Maternal subclinical hypothyroidism (SCH) is a risk factor for adverse pregnancy outcomes. However, it is still unclear whether SCH affects male fertility. The aim of this study was to determine the association between paternal SCH and clinical outcomes after in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI). METHODS: This retrospective study included 2511 couples with paternal euthyroidism (n=2282) or SCH (n=229) who visited our clinic for infertility treatment between April 1, 2017 and...
Source: Thyroid : official journal of the American Thyroid Association - July 2, 2020 Category: Endocrinology Tags: Thyroid Source Type: research