Thyroid autoimmunity and dysfunction in Sri Lankan children and adolescents after twenty two years of sustained universal salt iodisation.
Conclusions Sri Lanka has safely and effectively implemented USI with good sources of iodine, leading to sustained iodine sufficiency over more than two decades. The early post-iodisation TgAb surge (42.1%) has settled (6.4%), and despite a persistently high TPOAb prevalence (10.3%), SCH prevalence remains reassuringly low (3%). Further studies should be undertaken to monitor thyroid autoimmune dysfunction in Sri Lankan children, using age specific, population derived reference ranges. PMID: 33406977 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - January 9, 2021 Category: Endocrinology Tags: Thyroid Source Type: research

Increased hepatic fat content in patients with resistance to thyroid hormone beta.
CONCLUSIONS: Our findings provide evidence that impairments in intra-hepatic TRβ-signaling due to mutations of the THRB gene can lead to hepatic steatosis, which emphasizes the influence of TH in the liver metabolism of lipids and provides a rationale for the development TRβ-selective thyromimetics. Consequently, new molecules with a very high TRβ affinity and hepatic selectivity have been developed for the treatment of lipid-associated hepatic disorders, particularly non-alcoholic fatty liver disease. PMID: 33353459 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - December 30, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Abnormal liver blood tests in patients with hyperthyroidism: systematic review and meta-analysis.
Authors: Scappaticcio L, Longo M, Maiorino MI, Pernice V, Caruso P, Esposito K, Bellastella G Abstract BACKGROUND: Abnormal liver blood tests (LBT) in hyperthyroid patients are not uncommonly encountered. One major adverse event of antithyroid drug (ATD) therapy is drug-induced hepatotoxicity. Abnormal LBTs in the hyperthyroidism scenario is a main diagnostic and therapeutic dilemma. We aimed to assess the prevalence and the response to ATD therapy of LBT abnormalities in newly diagnosed and uncomplicated hyperthyroidism through a systematic review and meta-analysis. METHODS: A literature search was performed r...
Source: Thyroid : official journal of the American Thyroid Association - December 18, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Incidence of Iodine-induced Hyperthyroidism after Administration of Iodinated Contrast during Radiographic Procedures: A Systematic Review and Meta-analysis of the Literature.
CONCLUSION: The incidence of IIH following ICM administration during radiographic procedures is extremely low. PMID: 33327840 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - December 18, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Thyroid 2020 to 2021.
Authors: Kebebew E Abstract NA. PMID: 33327860 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - December 18, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Farewell Thyroid.
Authors: Kopp PA PMID: 33332246 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - December 18, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Brain gene expression in systemic hypothyroidism and mouse models of MCT8 deficiency: The Mct8-Oatp1c1-Dio2 triad.
CONCLUSION: The results indicate that the neurological impairment of AHDS is too severe to be fully explained by TH deprivation only. PMID: 33307956 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - December 16, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Pro64His (rs4644) polymorphism within galectin-3 is a risk factor of differentiated thyroid carcinoma and affects the transcriptome of thyrocytes engineered via CRISPR/Cas9 system.
CONCLUSIONS: Our data showed that in thyroid rs4644 is a trans-expression quantitative trait locus that can modify the transcriptional expression of downstream genes, through the modulation of TTF-1 and, likely, also of other transcriptional factors such as TCF4. PMID: 33308024 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - December 16, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Acknowledgment of Reviewers: 2019-2020.
Authors: PMID: 33306016 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - December 13, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Future Meetings.
Authors: PMID: 33306017 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - December 13, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Interobserver Reproducibility in Sonographic Measurement of Diameter and Volume of Papillary Thyroid Microcarinoma.
CONCLUSION: For PTMC, a difference of up to 24% in the maximum diameter and 72% in the volume may be considered to be within measurement error on US. This value may be used to determine the cut-off for defining meaningful change in the maximum diameter and volume for PTMC during active surveillance. PMID: 33287640 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - December 10, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Trends in Thyroid Surgery and Guideline-Concordant Care in the United States, 2007-2018.
Conclusions: There was a significant changepoint occurring in November 2015 in the operative and management trends for benign and malignant thyroid disease. PMID: 33280499 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - December 8, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Evidence Based Use of LT4/LT3 Combinations in Treating Hypothyroidism: A Consensus Document.
Discussion This manuscript summarizes the areas discussed and presents Consensus Statements to guide development of future clinical trials of LT4/LT3 combination therapy. The results of such redesigned trials are expected to be of benefit to patients and of value to inform future thyroid hormone replacement clinical practice guidelines treatment recommendations. PMID: 33276704 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - December 7, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Congenital hypothyroidism: a 2020 consensus guidelines update An ENDO-EUROPEAN REFERENCE NETWORK (ERN) initiative endorsed by the European Society for Pediatric Endocrinology and the European Society for Endocrinology.
Conclusions This consensus guidelines update should be used to further optimize detection, diagnosis, treatment and follow-up of children with all forms of CH in the light of the most recent evidence. It should be helpful in convincing health authorities of the benefits of neonatal screening for CH. Further epidemiological and experimental studies are needed to understand the increased incidence of this condition. PMID: 33272083 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - December 6, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Urinary Iodine Concentrations in Pregnant Women and Offspring Brain Morphology.
This study was embedded within Generation R, a prospective population-based birth cohort in Rotterdam, the Netherlands. We included 990 mother-child pairs with data on urinary iodine concentration (UIC) and creatinine during pregnancy. UIC was assessed at
Source: Thyroid : official journal of the American Thyroid Association - December 4, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Thyroid hormone receptor α1 mutants impair B lymphocyte development in a mouse model.
CONCLUSIONS: Analysis of lymphopoiesis in a mouse model of RTH showed that B cell lymphopoiesis was suppressed by TR1 mutations. The suppressed development of B cells was, at least in part, via inhibition of the expression of key regulators, Ebf1, Tcf3, and Pax5, by TR1 mutations. These findings suggest the mutations of the THRA gene in patients could lead to B cell deficiency. PMID: 33267733 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - December 4, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Obesity and monitoring iodine nutritional status in schoolchildren: is body mass index a factor to consider?
Authors: De Angelis S, Bagnasco M, Moleti M, Regalbuto C, Tonacchera M, Vermiglio F, Medda E, Rotondi D, Di Cosmo C, Dimida A, Rago T, Schiavo M, Nazzari E, Bossert I, Sturniolo G, Cesaretti G, Olivieri A Abstract BACKGROUND: The frequency of overweight and obese children has increased worldwide, particularly in economically developed countries. No studies have been conducted to verify whether the increasing frequency of overweight and obesity in schoolchildren may affect the evaluation of iodine nutritional status in populations. The aim of this study was to verify whether urinary iodine concentration, thyroid vol...
Source: Thyroid : official journal of the American Thyroid Association - December 3, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Growth differentiation factor 15 is a cancer cell-induced mitokine that primes thyroid cancer cells for invasiveness.
CONCLUSIONS: Here we demonstrated that GDF15 is a mitokine induced by thyroid cancer cells upon mitochondrial stress. GDF15-induced STAT3 activation determined tumor progression in thyroid cancer. The GDF15-STAT3 signaling axis may be a target for controlling the aggressiveness of thyroid cancer. PMID: 33256569 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - December 3, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Efficacy profile and safety implications of very low dose rituximab in patients with graves' orbitopathy.
CONCLUSIONS: A dose of 100 mg RTX is effective in patients with active moderate-severe GO. Low doses are better tolerated, expose patients to immune suppression for a shorter period of time and are extremely cost effective, compared to higher doses. This dose, consistently with all other immunosuppressants, does not prevent the progression of GO to dysthyroid optic neuropathy. PMID: 33234032 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - November 27, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Ca19.9 positivity and doubling time are prognostic factors of mortality in patients with advanced medullary thyroid cancer with no evidence of structural disease progression according to RECIST.
Authors: Lorusso L, Romei C, Piaggi P, Fustini C, Molinaro E, Agate L, Bottici V, Viola D, Pellegrini G, Elisei R Abstract BACKGROUND: Serum Ca19.9 positivity is a prognostic factor for mortality in patients with advanced medullary thyroid cancer (aMTC), independently from calcitonin (Ct) doubling time (DT). However, it is unknown whether aMTC patients who become positive for Ca19.9 also have progressive disease (PD) according to Response Evaluation Criteria in Solid Tumors (RECIST) and whether Ca19.9 DT has a role in the management of aMTC patients. The aims of this study was to evaluate whether in aMTC, when seru...
Source: Thyroid : official journal of the American Thyroid Association - November 27, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Gut microbiota may play a significant role in the pathogenesis of Graves' disease.
Authors: Jiang W, Yu X, Kosik RO, Song Y, Qiao T, Tong J, Liu S, Fan S, Luo Q, Chai L, Lv Z, Li D Abstract BACKGROUND: Gut microbiota are considered to be intrinsic regulators of thyroid autoimmunity. We designed a cross-sectional study to examine the makeup and metabolic function of microbiota in Graves' disease (GD) patients, with the ultimate aim of offering new perspectives on the diagnosis and treatment of GD. METHODS: The 16S rRNA V3-V4 DNA regions of microbiota were obtained from fecal samples collected from 45 GD patients and 59 controls. Microbial differences between the two groups were subsequently an...
Source: Thyroid : official journal of the American Thyroid Association - November 27, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Terminology change for small low-risk papillary thyroid cancer as a response to overtreatment: Results from three Australian community juries.
CONCLUSIONS: The conceptual tension between a pathological and an outcomes-based understanding of cancer was apparent in deliberation. This highlights an ongoing challenge for those advocating changing disease terminology. Regardless of action on terminology, jurors shared a strong expectation that practical changes would be made to respond to the harms of overtreatment. PMID: 33238815 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - November 27, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Hypothyroidism increases cholesterol gallstone prevalence in mice by elevated hydrophobicity of primary bile acids.
CONCLUSIONS: We describe a novel pathogenic link between TH deficiency and CGD and suggest that the increased hydrophobic character of biliary BAs due to the diminished expression of hepatic detoxification enzymes promotes cholesterol crystal precipitation and finally enhances cholesterol gallstone formation in the bile of hypothyroid mice. PMID: 33231505 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - November 26, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

TSHR-specific lymphocytes in Ad-TSHR-immunized native and HLA-DR3-transgenic mice and in Graves ´ disease patient blood using MHCII tetramers.
CONCLUSIONS: Novel MHC II tetramers identified TSHR-specific T lymphocytes in Ad-TSHR-immunized hyperthyroid BALB/c or HLA-DR3-transgenic mice, and in thawed human PBMCs from Graves´ patients. These assays may contribute significantly to measure both, disease severity and effects of novel immune therapies in future animal studies and clinical investigations of Graves´ disease. PMID: 33208049 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - November 21, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Early diagnosis and treatment of an infant with a novel THRA gene (pC380SfsX9) mutation.
Authors: Furman AE, Dumitrescu AM, Refetoff S, Weiss RE Abstract Resistance to thyroid hormone (RTH) ⍺ is caused by mutations in THRA. Little is known about the natural history and treatment of RTH⍺ and diagnosis before the age of 1 year has not been previously reported. A de novo heterozygous THRA mutation (pC380SfsX9) was identified in a 10-month-old female investigated for developmental delay, hypotonia, macrocephaly and severe constipation. Treatment with levothyroxine was accompanied by an appropriate rise in T4, T3, as well as decrease in TSH levels and in the T3/T4 ratio with a trend toward normalization...
Source: Thyroid : official journal of the American Thyroid Association - November 18, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Thyroid function and physical activity: a population-based cohort study.
CONCLUSIONS: We did not observe an association between the endogenous thyroid hormones and total physical activity. Further studies need to be performed to evaluate whether thyroid hormone replacement therapy is associated with physical activity. PMID: 33198599 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - November 18, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

18F-Fluorocholine PET/CT is a highly sensitive but poorly specific tool for identifying malignancy in thyroid nodules with indeterminate cytology: The Chocolate study.
Authors: Ciappuccini R, Licaj I, Lasne-Cardon A, Babin E, de Raucourt D, Blanchard D, Bastit V, Saguet-Rysanek V, Lequesne J, Peyronnet D, Grellard JM, Clarisse B, Bardet S Abstract Background Refining the risk of malignancy in patients presenting thyroid nodules with indeterminate cytology (IC) is a critical challenge. We investigated the performances of 18F-Fluorocholine (FCH) PET/CT to predict malignancy. Methods Between May 2016 and March 2019, 107 patients presenting a thyroid nodule ≥15 mm with IC and eligible for surgery were prospectively included (ClinicalTrials.gov identifier: NCT02784223). Head-and-ne...
Source: Thyroid : official journal of the American Thyroid Association - November 17, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Congenital hypothyroidism: Space-time clustering of thyroid dysgenesis indicates a role for environmental factors in disease etiology.
Authors: McNally R, Jones JH, Shaikh MG, Donaldson M, Blakey K, Cheetham T Abstract BACKGROUND: The etiology of most cases of congenital hypothyroidism (CHT) due to thyroid dysgenesis is unknown. If transient environmental factors can impact on thyroid gland development then clustering of cases in time and / or space may occur and this would be more likely in thyroid dysgenesis than dyshormonogenesis. METHODS: The newborn screening programme for CHT in Scotland is linked to a central database that includes case details such as post-code. The etiology of CHT is investigated in many cases of CHT using scintigraph...
Source: Thyroid : official journal of the American Thyroid Association - November 17, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

PET imaging in medullary thyroid carcinoma: time for reappraisal?
This article focuses on the clinical value of PET imaging in the commonest clinical scenarios (prior initial thyroidectomy, prior cervical reoperations for persistent/recurrent disease and in the follow-up of metastatic cases). PMID: 33191866 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - November 17, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

< i > PLEKHS1 < /i > mutations in thyroid cancers.
PLEKHS1 mutations in thyroid cancers. Thyroid. 2020 Nov 15;: Authors: Landa I Abstract N/A. PMID: 33191868 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - November 17, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Expression and role of thyroid-stimulating hormone receptors in proopiomelanocortin-producing pituitary cells.
CONCLUSIONS: These results indicate that TSH is a potential paracrine modulator of anterior pituitary corticotrophs and melanotrophs, controlling the exocytotic but not the transcriptional pathway in a cAMP/calcium influx-dependent manner. PMID: 33191870 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - November 17, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Knowledge, attitudes, beliefs, and treatment burden related to the use of levothyroxine in hypothyroid pregnant women in the United States.
CONCLUSIONS: Our findings support the need for increased, effective communication and tailored counseling to address fears, anxiety, and uncertainties about the benefits and risks of LT4 use in pregnancy. For patients with clear benefits from LT4 treatment in pregnancy, it could help to overcome their concerns, promote adherence, and decrease adverse maternofetal outcomes. For patients with no clear benefits established, clinicians need to be aware of LT4-related treatment burden in pregnancy and implement patient-centered approaches in their clinical practices. PMID: 33176609 [PubMed - as supplied by publisher] (Sourc...
Source: Thyroid : official journal of the American Thyroid Association - November 14, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

A positive feedback loop between DICER1 and differentiation transcription factors is important for thyroid tumorigenesis.
CONCLUSIONS: The differentiation transcription factors NKX2.1, PAX8, and CREB act in a positive feedback loop with DICER1. As the expression of these transcription factors is markedly diminished in thyroid cancer, our findings suggest that DICER1 downregulation in this cancer is mediated, at least partly, through impairment of its transcription. PMID: 33176626 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - November 14, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Clinical Outcomes After Discontinuation of Thyroid Hormone Replacement - A Systematic Review and Meta-Analysis.
CONCLUSIONS: Low quality evidence suggests that up to a third of patients remained euthyroid after LT4 discontinuation, with a higher proportion of patients with an initial diagnosis of subclinical hypothyroidism remaining euthyroid than patients with an initial diagnosis of overt hypothyroidism. A deprescribing framework focusing on adequate selection of patients for deprescribing LT4 and a systematic process is warranted to guide clinicians in re-evaluating the need for LT4 in their patients. PMID: 33161885 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - November 11, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Papillary thyroid carcinoma in Ukraine after Chernobyl and in Japan after Fukushima: different histopathological scenarios.
CONCLUSIONS: The difference in morphological features that indicate biological behavior of PTC between the radiation-related and sporadic groups from Ukraine, together with the lack of such in the two groups from Japan, strongly suggest a non-radiogenic etiology of PTC from Fukushima and other Prefectures. PMID: 33143557 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - November 6, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Papillary Thyroid Carcinoma with High-Grade Features Versus Poorly Differentiated Thyroid Carcinoma: An Analysis of Clinicopathologic and Molecular Features and Outcome.
Authors: Wong KS, Dong F, Telatar M, Lorch J, Alexander EK, Marqusee E, Cho NL, Nehs MA, Doherty GM, Afkhami M, Barletta J Abstract BACKGROUND: Similar to poorly differentiated thyroid carcinoma (PDTC), papillary thyroid carcinoma with high-grade features (PTC HGF) demonstrates increased mitotic activity and/or necrosis; however, PTC HGF is excluded from the WHO definition of PDTC based on maintained nuclear features of PTC. METHODS: Consecutive tumors that met criteria for PTC HGF, defined as tumors with maintained nuclear features of PTC and mitoses numbering 5 or more per 10 contiguous high power fields and/...
Source: Thyroid : official journal of the American Thyroid Association - November 6, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

< i > < b > Combining the American Thyroid Association's ultrasound classification with cytological subcategorization improves the assessment of malignancy risk in indeterminate thyroid nodules < /b > < /i > .
Conclusions: The RoM of ITNs can reach almost 80% when both nuclear atypia and ATA-based high-risk US features are present. The presence of such cytological features also increased the RoM in the ATA-based intermediate-risk US category. Additionally, AA and OP were not independently related to higher cancer risk. These results strengthen the recommendations for combing cytological subcategorization and US risk classification in the work up for ITNs prior to the decision of a molecular testing, clinical observation or diagnostic surgery. PMID: 33143569 [PubMed - as supplied by publisher] (Source: Thyroid : official jour...
Source: Thyroid : official journal of the American Thyroid Association - November 6, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Exposure to the Chinese Great Famine in early life and thyroid function and disorders in adulthood: a cross-sectional study.
CONCLUSIONS: Famine exposure during the fetal stage was associated with a higher TSH level in adulthood. The fetal stage could be the critical period for programming the pituitary-thyroid axis. PMID: 33138723 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - November 4, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Thyroid hormone deficiency suppresses fetal pituitary-adrenal function near term: implications for the control of fetal maturation and parturition.
Conclusions Thyroid hormones are important regulators of the structure and secretory capacity of the pituitary-adrenal axis before birth. In hypothyroid fetuses, low plasma cortisol may be due to impaired adrenocortical growth and steroidogenic enzyme expression, secondary to low circulating ACTH concentration. Greater corticotroph population in the anterior pituitary gland of the hypothyroid fetus indicates compensatory cell proliferation and that there may be abnormal corticotroph capacity for ACTH synthesis and/or impaired hypothalamic input. Suppression of the development of the fetal HPA axis by thyroid hormone defici...
Source: Thyroid : official journal of the American Thyroid Association - November 3, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Endocrinologist perceived factors affecting the transition of thyroid cancer patients from specialist to primary care post-cancer treatment in Ontario, Canada.
CONCLUSION: The lack of consensus amongst endocrinologists affects the transition of patient care, and there is a need to provide clear and accurate information to primary care physicians and thyroid cancer patients on post-cancer treatment care. Efforts should be sought to standardize discharge and long-term care. PMID: 33121388 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - November 1, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Thyroid Laboratory Testing and Management in Women on Thyroid Replacement Prior to Pregnancy and Associated Pregnancy Outcomes.
CONCLUSIONS: Although most women on thyroid replacement prior to conception had TSH measured at some point during pregnancy, it is concerning that 17.8% did not. Levothyroxine overtreatment in pregnancy was associated with preterm delivery. These findings suggest that clinicians should be careful to avoid overtreatment with levothyroxine in pregnancy. PMID: 33108964 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - October 29, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Predicting Outcomes in Sporadic and Hereditary Medullary Thyroid Carcinoma over Two Decades.
CONCLUSIONS: Disease burden during initial surgery, especially gross ETE, lateral neck LN involvement and distant metastases, as well as the biochemical response to surgery appear to be more important than demographic factors in terms of MTC prognosis. These findings highlight the importance of rigorous perioperative assessment to better predict MTC outcomes. PMID: 33108969 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - October 29, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Fine-tuning lipid metabolism by targeting mitochondria-associated Acetyl-CoA-Carboxylase 2 in BRAFV600E papillary thyroid carcinoma.
CONCLUSIONS: These findings suggest a potential link between BRAFV600E and lipid metabolism regulation in PTC. BRAFV600E down-regulates ACC2 levels, which deregulates de novo lipid synthesis, FAO due to OCR, and ECAR rates. ShACC2 may contribute to vemurafenib resistance and increased tumor growth. ACC2 rescue may represent a novel molecular strategy for overcoming resistance to BRAFV600E inhibitors in refractory PTC. PMID: 33107403 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - October 28, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Trends in Pediatric Thyroid Cancer Incidence, Treatment, and Clinical Course in Korea during 2004-2016: A Nationwide Population-Based Study.
Authors: Lee YA, Yun HR, Lee J, Moon H, Shin CH, Kim SG, Park YJ Abstract BACKGROUND: The incidence of thyroid cancer has increased worldwide. We investigated nationwide trends in the incidence and treatment course of pediatric thyroid cancer in South Korea. METHODS: Using the National Health Information Database, we analyzed 1,580 patients (324 males)
Source: Thyroid : official journal of the American Thyroid Association - October 28, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Re: "Association Between Thionamides and Acute Pancreatitis: A Case-Control Study" by Guo et al.
Re: "Association Between Thionamides and Acute Pancreatitis: A Case-Control Study" by Guo et al. Thyroid. 2020 Oct 21;: Authors: Brix TH, Hegedüs L, Bonnema SJ, Hallas J, Lund LC PMID: 33090081 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - October 24, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

A Promising Mouse Model of Graves' Orbitopathy Induced by Adenovirus Expressing Thyrotropin Receptor A Subunit.
CONCLUSIONS: A GO mouse model was successfully established by administering 9 injections of Ad-TSHRA. The model was achieved with a frequency of 70% and revealed the importance of T-cell immunity. A potential time window from Graves' hyperthyroidism to GO was presented for the first time. Therefore, this model could be used to study the pathogenesis and novel treatments for GO. PMID: 33076782 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - October 22, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

A role of endogenous histone acetyltransferase steroid hormone receptor coactivator (SRC) 3 in thyroid hormone signaling during Xenopus intestinal metamorphosis.
CONCLUSION: Our results thus demonstrate that SRC3 is a critical component of the TR-signaling pathway in vivo during intestinal remodeling. PMID: 33076783 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - October 22, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Triiodothyronine use in hypothyroidism and its effects on cancer and mortality.
CONCLUSIONS: In this large Swedish long-term register-based study, the use of T3 did not lead to increased breast cancer incidence, any cancer incidence, all-cause mortality, any cancer mortality, or breast cancer mortality compared to T4 use. Somewhat surprisingly, there was evidence of lower mortality in T3 users in models adjusting for dose, potentially an artifact of underlying associations between dose and health status/diagnosis. PMID: 33040688 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - October 14, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Indications and strategy for active surveillance of adult low-risk papillary thyroid microcarcinoma: consensus statements from the Japan Association of Endocrine Surgery task force on management for papillary thyroid microcarcinoma.
CONCLUSIONS: An appropriate multidisciplinary team is necessary to accurately evaluate primary tumors and lymph nodes at the beginning of and during AS, and to adequately reach a shared-decision with individual patients. If appropriately applied, AS of low-risk PTMC is a safe management strategy offering favorable outcomes and preserves quality of life at low cost. PMID: 33023426 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - October 9, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Effects of hyperthyroidism on adipose tissue activity and distribution in adults.
CONCLUSIONS: Our results suggest that the contribution of increased TH levels to the glucose uptake of BAT and WAT is low compared with that of the skeletal muscle. Hyperthyroid subjects have reduced areas of visceral adipose tissue and by increased AFABP levels. PMID: 33019884 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - October 8, 2020 Category: Endocrinology Tags: Thyroid Source Type: research