Thyroid Collars in Dental Radiology: 2021 Update
CONCLUSIONS: We list seven areas that should be pursued. Among them are harmonizing guidelines for the use of thyroid collars based on the recent studies and a comprehensive survey of current dental radiological practice patterns.PMID:33849309 | DOI:10.1089/thy.2021.0087 (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - April 14, 2021 Category: Endocrinology Authors: Arthur B Schneider Michael M Kaplan Dan V Mihailescu Source Type: research

Korean Society of Thyroid Radiology (KSThR) guidelines for the management of pediatric thyroid nodules: Suitability and risk factors
CONCLUSION: For the management of thyroid nodules in children, it is necessary to consider risk factors and adjust the criteria values for FNA. FNA should be considered in children with risk factors for thyroid cancer even if thyroid nodules are small.PMID:33832344 | DOI:10.1089/thy.2020.0875 (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - April 9, 2021 Category: Endocrinology Authors: Seul Bi Lee Yeon Jin Cho Seunghyun Lee Young Hun Choi Jung-Eun Cheon Woo Sun Kim Source Type: research

Re: "The use of the Bethesda System for Reporting Thyroid Cytopathology in pediatric thyroid nodules - A meta-analysis" by Vuong, et al
Thyroid. 2021 Apr 5. doi: 10.1089/thy.2021.0116. Online ahead of print.ABSTRACTNone.PMID:33820454 | DOI:10.1089/thy.2021.0116 (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - April 6, 2021 Category: Endocrinology Authors: Christine E Cherella Edmund S Cibas Ari J Wassner Source Type: research

Repeat Fine Needle Aspiration Cytology Refines the Selection of Thyroid Nodules for Afirma Gene Expression Classifier Testing
CONCLUSIONS: Repeat FNA cytology can guide the selection of cytologically indeterminate thyroid nodules that warrant MT. The Restrictive model of performing Afirma GEC only on nodules with 2 separate biopsies showing Bethesda III/IV cytology would reduce the rate of diagnostic surgery for histologically benign nodules while missing only rare low-risk tumors. Given the low but nontrivial risks of thyroidectomy, the higher specificity of the Restrictive testing approach disproportionately outweighs the potential harms.PMID:33813868 | DOI:10.1089/thy.2020.0969 (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - April 5, 2021 Category: Endocrinology Authors: Michiya Nishino Roselyn Mateo Holly Kilim Anna Feldman Amanda Elliott Changyu Shen Per-Olof Hasselgren Helen Wang Pamela Hartzband James V Hennessey Source Type: research

A joint statement from the american thyroid association, the european association of nuclear medicine, the european thyroid association, the society of nuclear medicine and molecular imaging on current diagnostic and theranostic approaches in the management of thyroid cancer
CONCLUSIONS: The inter-societal working group agreed that: 1) initial patient management decisions should be guided by peri-operative risk stratification which should include the 8th edition AJCC system to predict disease specific mortality, the modified 2009 ATA risk stratification system to estimate structural disease recurrence, with judicious incorporation of molecular theranostics to further refine management recommendations ; 2) diagnostic radioactive iodine scanning in ATA intermediate risk patients should be utilized selectively rather than being considered mandatory or not necessary for all patients in this catego...
Source: Thyroid : official journal of the American Thyroid Association - April 1, 2021 Category: Endocrinology Authors: Seza A Gulec Sukhjeet Ahuja Anca Avram Victor Bernet Patrick Bourguet Ciprian Draganescu Rossella Elisei Luca Giovanella Frederick D Grant Bennett Greenspan Laszlo Hegedus Jacqueline Jonklaas Richard T Kloos Markus Luster Wim Jg Oyen Johannes Smit Robert Source Type: research

A joint statement from the american thyroid association
CONCLUSIONS: The inter-societal working group agreed that: 1) initial patient management decisions should be guided by peri-operative risk stratification which should include the 8th edition AJCC system to predict disease specific mortality, the modified 2009 ATA risk stratification system to estimate structural disease recurrence, with judicious incorporation of molecular theranostics to further refine management recommendations ; 2) diagnostic radioactive iodine scanning in ATA intermediate risk patients should be utilized selectively rather than being considered mandatory or not necessary for all patients in this catego...
Source: Thyroid : official journal of the American Thyroid Association - April 1, 2021 Category: Endocrinology Authors: Seza A Gulec Sukhjeet Ahuja Anca Avram Victor Bernet Patrick Bourguet Ciprian Draganescu Rossella Elisei Luca Giovanella Frederick D Grant Bennett Greenspan Laszlo Hegedus Jacqueline Jonklaas Richard T Kloos Markus Luster Wim Jg Oyen Johannes Smit Robert Source Type: research

TSH Suppression for Papillary Thyroid Cancer: A Physician Survey Study
CONCLUSION: Many patients with low-risk thyroid cancer continue to be treated with suppressive doses of thyroid hormone, emphasizing the need for more high quality research to guide thyroid cancer management, as well as better understanding of barriers that hinder guideline adoption.PMID:33779292 | DOI:10.1089/thy.2021.0033 (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - March 29, 2021 Category: Endocrinology Authors: Maria Papaleontiou Debbie Chen Mousumi Banerjee David Reyes-Gastelum Ann S Hamilton Kevin C Ward Megan R Haymart Source Type: research

The iodide transport defect-causing Y348D mutation in the Na < sup > + < /sup > /I < sup > - < /sup > symporter (NIS) renders the protein intrinsically inactive and impairs its targeting to the plasma membrane
CONCLUSIONS: Y348D NIS does not reach the plasma membrane and is intrinsically inactive. Hydrophobic amino acid substitutions at position 348, however, preserve NIS activity. Our findings are consistent with our homology model's prediction that Y348 should face the side opposite the TMS9 residues that coordinate Na+ and participate in Na+ transport, and with the notion that Y348 interacts only with hydrophobic residues. Hydrophilic or charged residues at position 348 have deleterious effects on NIS plasma membrane targeting and activity, whereas a hydrophobic residue at this position rescues NIS activity.PMID:33779310 | DO...
Source: Thyroid : official journal of the American Thyroid Association - March 29, 2021 Category: Endocrinology Authors: Andrea Reyna-Neyra Lara Jung Mayukh Chakrabarti Mikel Suarez L Mario Amzel Nancy Carrasco Source Type: research

TSH Suppression for Papillary Thyroid Cancer: A Physician Survey Study
CONCLUSION: Many patients with low-risk thyroid cancer continue to be treated with suppressive doses of thyroid hormone, emphasizing the need for more high quality research to guide thyroid cancer management, as well as better understanding of barriers that hinder guideline adoption.PMID:33779292 | DOI:10.1089/thy.2021.0033 (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - March 29, 2021 Category: Endocrinology Authors: Maria Papaleontiou Debbie Chen Mousumi Banerjee David Reyes-Gastelum Ann S Hamilton Kevin C Ward Megan R Haymart Source Type: research

The iodide transport defect-causing Y348D mutation in the Na < sup > + < /sup > /I < sup > - < /sup > symporter (NIS) renders the protein intrinsically inactive and impairs its targeting to the plasma membrane
CONCLUSIONS: Y348D NIS does not reach the plasma membrane and is intrinsically inactive. Hydrophobic amino acid substitutions at position 348, however, preserve NIS activity. Our findings are consistent with our homology model's prediction that Y348 should face the side opposite the TMS9 residues that coordinate Na+ and participate in Na+ transport, and with the notion that Y348 interacts only with hydrophobic residues. Hydrophilic or charged residues at position 348 have deleterious effects on NIS plasma membrane targeting and activity, whereas a hydrophobic residue at this position rescues NIS activity.PMID:33779310 | DO...
Source: Thyroid : official journal of the American Thyroid Association - March 29, 2021 Category: Endocrinology Authors: Andrea Reyna-Neyra Lara Jung Mayukh Chakrabarti Mikel Suarez L Mario Amzel Nancy Carrasco Source Type: research

TSH Suppression for Papillary Thyroid Cancer: A Physician Survey Study
CONCLUSION: Many patients with low-risk thyroid cancer continue to be treated with suppressive doses of thyroid hormone, emphasizing the need for more high quality research to guide thyroid cancer management, as well as better understanding of barriers that hinder guideline adoption.PMID:33779292 | DOI:10.1089/thy.2021.0033 (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - March 29, 2021 Category: Endocrinology Authors: Maria Papaleontiou Debbie Chen Mousumi Banerjee David Reyes-Gastelum Ann S Hamilton Kevin C Ward Megan R Haymart Source Type: research

The iodide transport defect-causing Y348D mutation in the Na < sup > + < /sup > /I < sup > - < /sup > symporter (NIS) renders the protein intrinsically inactive and impairs its targeting to the plasma membrane
CONCLUSIONS: Y348D NIS does not reach the plasma membrane and is intrinsically inactive. Hydrophobic amino acid substitutions at position 348, however, preserve NIS activity. Our findings are consistent with our homology model's prediction that Y348 should face the side opposite the TMS9 residues that coordinate Na+ and participate in Na+ transport, and with the notion that Y348 interacts only with hydrophobic residues. Hydrophilic or charged residues at position 348 have deleterious effects on NIS plasma membrane targeting and activity, whereas a hydrophobic residue at this position rescues NIS activity.PMID:33779310 | DO...
Source: Thyroid : official journal of the American Thyroid Association - March 29, 2021 Category: Endocrinology Authors: Andrea Reyna-Neyra Lara Jung Mayukh Chakrabarti Mikel Suarez L Mario Amzel Nancy Carrasco Source Type: research

Competing Causes of Death in Older Adults with Thyroid Cancer
CONCLUSION: The clinical context, including patients' specific comorbidities, should be considered when diagnosing and managing thyroid cancer. Our findings can be used to develop decision models that account for competing causes of death, as an aid for clinical decision making.PMID:33764188 | DOI:10.1089/thy.2020.0929 (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - March 25, 2021 Category: Endocrinology Authors: Maria Papaleontiou Edward C Norton David Reyes-Gastelum Mousumi Banerjee Megan R Haymart Source Type: research

Single institution experience with afirma and thyroseq testing in indeterminate thyroid nodules
Thyroid. 2021 Mar 25. doi: 10.1089/thy.2020.0801. Online ahead of print.ABSTRACTBACKGROUND: Thyroid nodules are a very common, often incidental finding on physical exam or imaging. Of those that undergo fine needle aspiration, cytology is indeterminate in up to 15%. Molecular testing is increasingly being used to help identify which nodules may be high risk for malignancy and guide management in regard to clinical follow up or surgical intervention. Recently there has been an increase in publication of independent studies assessing the performance of these molecular tests and comparing "real world" data to the va...
Source: Thyroid : official journal of the American Thyroid Association - March 25, 2021 Category: Endocrinology Authors: Michele Gortakowski Krystel Feghali Ibitoro N Osakwe Source Type: research

Competing Causes of Death in Older Adults with Thyroid Cancer
CONCLUSION: The clinical context, including patients' specific comorbidities, should be considered when diagnosing and managing thyroid cancer. Our findings can be used to develop decision models that account for competing causes of death, as an aid for clinical decision making.PMID:33764188 | DOI:10.1089/thy.2020.0929 (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - March 25, 2021 Category: Endocrinology Authors: Maria Papaleontiou Edward C Norton David Reyes-Gastelum Mousumi Banerjee Megan R Haymart Source Type: research

Single institution experience with afirma and thyroseq testing in indeterminate thyroid nodules
Thyroid. 2021 Mar 25. doi: 10.1089/thy.2020.0801. Online ahead of print.ABSTRACTBACKGROUND: Thyroid nodules are a very common, often incidental finding on physical exam or imaging. Of those that undergo fine needle aspiration, cytology is indeterminate in up to 15%. Molecular testing is increasingly being used to help identify which nodules may be high risk for malignancy and guide management in regard to clinical follow up or surgical intervention. Recently there has been an increase in publication of independent studies assessing the performance of these molecular tests and comparing "real world" data to the va...
Source: Thyroid : official journal of the American Thyroid Association - March 25, 2021 Category: Endocrinology Authors: Michele Gortakowski Krystel Feghali Ibitoro N Osakwe Source Type: research

Competing Causes of Death in Older Adults with Thyroid Cancer
CONCLUSION: The clinical context, including patients' specific comorbidities, should be considered when diagnosing and managing thyroid cancer. Our findings can be used to develop decision models that account for competing causes of death, as an aid for clinical decision making.PMID:33764188 | DOI:10.1089/thy.2020.0929 (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - March 25, 2021 Category: Endocrinology Authors: Maria Papaleontiou Edward C Norton David Reyes-Gastelum Mousumi Banerjee Megan R Haymart Source Type: research

Single institution experience with afirma and thyroseq testing in indeterminate thyroid nodules
Thyroid. 2021 Mar 25. doi: 10.1089/thy.2020.0801. Online ahead of print.ABSTRACTBACKGROUND: Thyroid nodules are a very common, often incidental finding on physical exam or imaging. Of those that undergo fine needle aspiration, cytology is indeterminate in up to 15%. Molecular testing is increasingly being used to help identify which nodules may be high risk for malignancy and guide management in regard to clinical follow up or surgical intervention. Recently there has been an increase in publication of independent studies assessing the performance of these molecular tests and comparing "real world" data to the va...
Source: Thyroid : official journal of the American Thyroid Association - March 25, 2021 Category: Endocrinology Authors: Michele Gortakowski Krystel Feghali Ibitoro N Osakwe Source Type: research

Letter to the Editor: Long Work Hours Are Associated with Hypothyroidism: A Cross-Sectional Study with Population-Representative Data by Lee et al. (DOI: 10.1089/thy.2019.0709)
Thyroid. 2021 Mar 23. doi: 10.1089/thy.2021.0105. Online ahead of print.ABSTRACTNone.PMID:33752470 | DOI:10.1089/thy.2021.0105 (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - March 23, 2021 Category: Endocrinology Authors: Jerome Hershman Source Type: research

2021 American Thyroid Association Guidelines for Management of Patients with Anaplastic Thyroid Cancer
Conclusions: We have developed evidence-based recommendations to inform clinical decision-making in the management of ATC. While all care must be individualized, such recommendations provide, in our opinion, optimal care paradigms for patients with ATC.PMID:33728999 | DOI:10.1089/thy.2020.0944 (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - March 17, 2021 Category: Endocrinology Authors: Keith C Bible Electron Kebebew James Brierley Juan P Brito Maria E Cabanillas Thomas J Clark Antonio Di Cristofano Robert Foote Thomas Giordano Jan Kasperbauer Kate Newbold Yuri E Nikiforov Gregory Randolph M Sara Rosenthal Anna M Sawka Manisha Shah Ashok Source Type: research

The transient human thyroid progenitor cell
CONCLUSION: Thyroid stem cells fall into the category of dispositional stem cells and are greatly influenced by their environment.PMID:33678005 | DOI:10.1089/thy.2020.0930 (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - March 8, 2021 Category: Endocrinology Authors: Terry F Davies Rauf Latif Ravi Sachidanandam Risheng Ma Source Type: research

Correlation of Performance Status and Neutrophil-Lymphocyte Ratio With Efficacy in Radioiodine-Refractory Differentiated Thyroid Cancer Treated With Lenvatinib
CONCLUSIONS: Lower ECOG PS and NLR may provide prognostic value for improved efficacy in patients with RR-DTC. .PMID:33637020 | DOI:10.1089/thy.2020.0779 (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - February 27, 2021 Category: Endocrinology Authors: Matthew H Taylor Shunji Takahashi Jaume Capdevila Makoto Tahara Sophie Leboulleux Naomi Kiyota Corina E Dutcus Ran Xie Bruce Robinson Steven I Sherman Mouhammed Amir Habra Rossella Elisei Lori J Wirth Source Type: research

Comparative analysis of the effects of long term 3,5-T2 treatment on the murine hepatic proteome and transcriptome under conditions of normal diet and high fat diet
CONCLUSION: While confirming the beneficial hepatic liver fat reduction by 3,5-T2 treatment, our data suggest that besides the well-known induction of fatty acid oxidation the stimulation of cholesterol- and bile acid synthesis with subsequent excretion of the latter via bile might represent a further important mechanism in this context. The obvious intensified male sex steroid exposition of the liver in 3,5-T2-treated HFD animals can be predicted to cause enhanced hepatic "masculinization", with not yet clear but potentially detrimental physiological consequences.PMID:33637021 | DOI:10.1089/thy.2020.0160 (Source...
Source: Thyroid : official journal of the American Thyroid Association - February 27, 2021 Category: Endocrinology Authors: Julika Lietzow Janine Golchert Maik Pietzner Uwe V ölker Matti Poutanen Claes Ohlsson Georg Homuth Josef K öhrle Source Type: research

Correlation of Performance Status and Neutrophil-Lymphocyte Ratio With Efficacy in Radioiodine-Refractory Differentiated Thyroid Cancer Treated With Lenvatinib
CONCLUSIONS: Lower ECOG PS and NLR may provide prognostic value for improved efficacy in patients with RR-DTC. .PMID:33637020 | DOI:10.1089/thy.2020.0779 (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - February 27, 2021 Category: Endocrinology Authors: Matthew H Taylor Shunji Takahashi Jaume Capdevila Makoto Tahara Sophie Leboulleux Naomi Kiyota Corina E Dutcus Ran Xie Bruce Robinson Steven I Sherman Mouhammed Amir Habra Rossella Elisei Lori J Wirth Source Type: research

Comparative analysis of the effects of long term 3,5-T2 treatment on the murine hepatic proteome and transcriptome under conditions of normal diet and high fat diet
CONCLUSION: While confirming the beneficial hepatic liver fat reduction by 3,5-T2 treatment, our data suggest that besides the well-known induction of fatty acid oxidation the stimulation of cholesterol- and bile acid synthesis with subsequent excretion of the latter via bile might represent a further important mechanism in this context. The obvious intensified male sex steroid exposition of the liver in 3,5-T2-treated HFD animals can be predicted to cause enhanced hepatic "masculinization", with not yet clear but potentially detrimental physiological consequences.PMID:33637021 | DOI:10.1089/thy.2020.0160 (Source...
Source: Thyroid : official journal of the American Thyroid Association - February 27, 2021 Category: Endocrinology Authors: Julika Lietzow Janine Golchert Maik Pietzner Uwe V ölker Matti Poutanen Claes Ohlsson Georg Homuth Josef K öhrle Source Type: research

Correlation of Performance Status and Neutrophil-Lymphocyte Ratio With Efficacy in Radioiodine-Refractory Differentiated Thyroid Cancer Treated With Lenvatinib
CONCLUSIONS: Lower ECOG PS and NLR may provide prognostic value for improved efficacy in patients with RR-DTC. .PMID:33637020 | DOI:10.1089/thy.2020.0779 (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - February 27, 2021 Category: Endocrinology Authors: Matthew H Taylor Shunji Takahashi Jaume Capdevila Makoto Tahara Sophie Leboulleux Naomi Kiyota Corina E Dutcus Ran Xie Bruce Robinson Steven I Sherman Mouhammed Amir Habra Rossella Elisei Lori J Wirth Source Type: research

Comparative analysis of the effects of long term 3,5-T2 treatment on the murine hepatic proteome and transcriptome under conditions of normal diet and high fat diet
CONCLUSION: While confirming the beneficial hepatic liver fat reduction by 3,5-T2 treatment, our data suggest that besides the well-known induction of fatty acid oxidation the stimulation of cholesterol- and bile acid synthesis with subsequent excretion of the latter via bile might represent a further important mechanism in this context. The obvious intensified male sex steroid exposition of the liver in 3,5-T2-treated HFD animals can be predicted to cause enhanced hepatic "masculinization", with not yet clear but potentially detrimental physiological consequences.PMID:33637021 | DOI:10.1089/thy.2020.0160 (Source...
Source: Thyroid : official journal of the American Thyroid Association - February 27, 2021 Category: Endocrinology Authors: Julika Lietzow Janine Golchert Maik Pietzner Uwe V ölker Matti Poutanen Claes Ohlsson Georg Homuth Josef K öhrle Source Type: research

Correlation of Performance Status and Neutrophil-Lymphocyte Ratio With Efficacy in Radioiodine-Refractory Differentiated Thyroid Cancer Treated With Lenvatinib
CONCLUSIONS: Lower ECOG PS and NLR may provide prognostic value for improved efficacy in patients with RR-DTC. .PMID:33637020 | DOI:10.1089/thy.2020.0779 (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - February 27, 2021 Category: Endocrinology Authors: Matthew H Taylor Shunji Takahashi Jaume Capdevila Makoto Tahara Sophie Leboulleux Naomi Kiyota Corina E Dutcus Ran Xie Bruce Robinson Steven I Sherman Mouhammed Amir Habra Rossella Elisei Lori J Wirth Source Type: research

Comparative analysis of the effects of long term 3,5-T2 treatment on the murine hepatic proteome and transcriptome under conditions of normal diet and high fat diet
CONCLUSION: While confirming the beneficial hepatic liver fat reduction by 3,5-T2 treatment, our data suggest that besides the well-known induction of fatty acid oxidation the stimulation of cholesterol- and bile acid synthesis with subsequent excretion of the latter via bile might represent a further important mechanism in this context. The obvious intensified male sex steroid exposition of the liver in 3,5-T2-treated HFD animals can be predicted to cause enhanced hepatic "masculinization", with not yet clear but potentially detrimental physiological consequences.PMID:33637021 | DOI:10.1089/thy.2020.0160 (Source...
Source: Thyroid : official journal of the American Thyroid Association - February 27, 2021 Category: Endocrinology Authors: Julika Lietzow Janine Golchert Maik Pietzner Uwe V ölker Matti Poutanen Claes Ohlsson Georg Homuth Josef K öhrle Source Type: research