The use of Tc-99m-Methoxy-Isobutyl-Isonitrile (MIBI) for differentiation of malignant thyroid nodules.
Authors: Hurtado-López LM, Duncker CM Abstract NA. PMID: 30892138 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - March 22, 2019 Category: Endocrinology Tags: Thyroid Source Type: research

99mTc-MIBI scan in patients with thyroid nodules: not for everyone but ….
99mTc-MIBI scan in patients with thyroid nodules: not for everyone but…. Thyroid. 2019 Mar 20;: Authors: Campenni A, Trimboli P, Giovanella L Abstract 99mTc-MIBI scan in patients with thyroid nodules: not for everyone but…. PMID: 30892146 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - March 22, 2019 Category: Endocrinology Tags: Thyroid Source Type: research

Redifferentiation of a BRAF-K601E mutated poorly differentiated thyroid cancer patient with dabrafenib and trametinib treatment.
Authors: Leboulleux S, Dupuy C, Lacroix L, Attard M, Grimaldi S, Corre R, Ricard M, Nasr S, Berdelou A, Hadoux J, Hartl D, Terroir M, Baudin E, Schlumberger M, Al Ghuzlan A Abstract A 59 years old woman with locally invasive poorly differentiated thyroid cancer with synchronous lung, mediastinal and bone metastases and a BRAF-K601E somatic mutation with contra-indication for antiangiogneic drugs was treated with dabrafenib and trametinib. During treatment, serum levels of thyroglobulin increased as soon as day 7 up to 10 folds over baseline at week 4. Concurrently, clinical hyperthyroidism occurred, with free T3 an...
Source: Thyroid : official journal of the American Thyroid Association - March 20, 2019 Category: Endocrinology Tags: Thyroid Source Type: research

Prostaglandin f2-alpha eye drops (bimatoprost) in graves' orbitopathy: a randomised controlled double masked crossover trial (bima trial).
CONCLUSION: In inactive GO, Bimatoprost treatment over a 3-month period does not result in an improvement in proptosis. PMID: 30880626 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - March 20, 2019 Category: Endocrinology Tags: Thyroid Source Type: research

Muscle performance and postural stability are reduced in patients with newly diagnosed Graves' disease.
CONCLUSION: At time of diagnosis, Graves' disease is associated with impaired maximum muscle strength, performance, and balance, whereas maximum force production is overall comparable to euthyroid controls. . PMID: 30880636 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - March 20, 2019 Category: Endocrinology Tags: Thyroid Source Type: research

response letter to paper by Sigal GA et al; Thyroid doi: 10.1089/thy.2018.0190. [Epub ahead of print].
Authors: Dullaart RPF Abstract no abstract required for response letter. PMID: 30887908 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - March 20, 2019 Category: Endocrinology Tags: Thyroid Source Type: research

Clinicopathologic Features of Mismatch Repair-Deficient Anaplastic Thyroid Carcinomas.
CONCLUSION: MMR-D tumors comprised 14% of our ATC cohort. Although the findings must be interpreted with caution given the small number of MMR-D ATC in our cohort, our results suggest that MMR status may be prognostically significant in ATC. PMID: 30869569 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - March 16, 2019 Category: Endocrinology Tags: Thyroid Source Type: research

Combination treatment with BRAFV600E inhibitor, vemurafenib, and BH3 mimetic, navitoclax, for BRAF mutant thyroid carcinoma.
Conclusions The results of the present study showed that vemurafenib increased the expression of anti-apoptotic proteins of the BCL-2 family. Thus, the combination of vemurafenib with navitoclax may be effective in BRAFV600E-positive PTC treatment. PMID: 30869573 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - March 16, 2019 Category: Endocrinology Tags: Thyroid Source Type: research

Acknowledgment of Reviewers: 2018.
Authors: PMID: 30874490 [PubMed - in process] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - March 16, 2019 Category: Endocrinology Tags: Thyroid Source Type: research

Tumor Volume Doubling Time in Active Surveillance of Papillary Thyroid Carcinoma.
Authors: Oh HS, Kwon H, Song E, Jeon M, Kim TY, Lee JH, Kim WB, Shong Y, Chung KW, Baek JH, Kim WG Abstract Background Tumor volume (TV) of papillary thyroid carcinoma (PTC) increases exponentially during active surveillance and the growth rate differs for each patient. TV doubling time (TVDT) is considered as a strong dynamic marker for the prediction of growth rate and progression of the tumor. Methods In this cohort study, we analyzed 273 PTC patients who underwent active surveillance for over one year rather than immediate thyroid surgery. TVDT was calculated in each patient and patients were divided into two g...
Source: Thyroid : official journal of the American Thyroid Association - March 15, 2019 Category: Endocrinology Tags: Thyroid Source Type: research

Low lymphocyte-to-monocyte ratios are associated with poor overall survival in anaplastic thyroid carcinoma patients.
Authors: Ahn J, Song E, Oh HS, Song DE, Kim WG, Kim TY, Kim WB, Shong Y, Jeon M Abstract BACKGROUND: The lymphocyte-to-monocyte ratio (LMR), which reflects the tumor infiltrating immune cell status and host immunity, has been reported as a prognostic marker in various cancers. The aim of the present study was to evaluate the role of LMR as a prognostic marker in predicting the survival of patients with anaplastic thyroid carcinoma (ATC). METHODS: We retrospectively included 35 ATC patients with available complete blood cell count (CBC) data. The primary outcome was the overall survival (OS) of patients with ATC...
Source: Thyroid : official journal of the American Thyroid Association - March 15, 2019 Category: Endocrinology Tags: Thyroid Source Type: research

Role of 18F-FCH PET/CT to detect structural relapse in high risk Differentiated Thyroid Cancer patients.
Authors: Piccardo A, Trimboli P, Puntoni M, Foppiani L, Treglia G, Shoushtari Zadeh Naseri M, Bottoni G, Massollo M, Sola S, Ferrarazzo G, Bruzzone M, Catrambone U, Arlandini A, Paone G, Ceriani L, Cabria M, Giovanella L Abstract AIM: to evaluate the role of 18F-Choline (18F-FCH) PET/CT in high-risk differentiated thyroid cancer (DTC) patients with suspected relapse. We also compared 18F-FCH-PET/CT results with those of 18F-FDG-PET/CT and evaluated the additional diagnostic value and clinical impact of the combined use of these two tracers. Finally, we assessed the association between the clinical, biochemical and ...
Source: Thyroid : official journal of the American Thyroid Association - March 15, 2019 Category: Endocrinology Tags: Thyroid Source Type: research

Clinical Experience with Rituximab and Intravenous Immunoglobulin for Pretibial myxedema: A Case Series.
CONCLUSIONS: Immunomodulation therapy was followed by PTM improvement or stability in most patients, with slightly better response after rituximab as compared to IVIg. A validated response assessment instrument and larger series of patients are required to determine if the underlying disease process could be curtailed with these agents. PMID: 30854936 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - March 13, 2019 Category: Endocrinology Tags: Thyroid Source Type: research

Short Review: Genomic alterations in H ürthle cell carcinoma.
Short Review: Genomic alterations in Hürthle cell carcinoma. Thyroid. 2019 Mar 08;: Authors: Ganly I, McFadden DG Abstract Hürthle cell tumors (HCT), including Hürthle cell adenomas (HCA) and Hürthle cell carcinomas (HCC) arise in the thyroid gland and are defined in part by an accumulation of mitochondria. These neoplasms were long considered a subtype of follicular neoplasm, although HCT is now generally considered a distinct entity. HCTs exhibit overlapping but distinct clinical features compared to follicular tumors, and several studies have demonstrated that HCTs harbor distinc...
Source: Thyroid : official journal of the American Thyroid Association - March 10, 2019 Category: Endocrinology Tags: Thyroid Source Type: research

Iodine Nutrition in U.S. Weaning Infants.
In this study, we report the current status of iodine nutrition among weaning infants in the U.S. METHODS: Subjects were infants
Source: Thyroid : official journal of the American Thyroid Association - March 6, 2019 Category: Endocrinology Tags: Thyroid Source Type: research

Different Thyroidal Responses to hCG Under Different TPOAb and/or TgAb Positivity Conditions During the First Half of Pregnancy.
CONCLUSIONS: When TSH was within the pregnancy-specific reference range, high concentrations of TPOAb and TgAb attenuated the FT4 stimulation and suppression of TSH by hCG. Our study implied that TgAb could also interfere with thyroidal responses to hCG during the first half of pregnancy in addition to TPOAb . PMID: 30808250 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - March 1, 2019 Category: Endocrinology Tags: Thyroid Source Type: research

Multifocality is not an Independent Prognostic Factor in Papillary Thyroid Cancer: A Propensity Score Matching Analysis.
Authors: Geron Y, Benbassat C, Steinschneider M, Or K, Markus E, Hirsch D, Levy S, Ziv-Baran T, Muallem Kalmovich L Abstract INTRODUCTION: Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy. Despite its low mortality rate, the disease has a persistence/recurrence rate of up to 30%. The mainstay of treatment for PTC is surgery, followed by radioiodine ablation and thyroxine therapy in appropriately selected patients. PTC can appear as a unifocal solitary tumor, but also as two or more anatomically separate foci. A great deal of controversy surrounds the significance of multifocality as a progn...
Source: Thyroid : official journal of the American Thyroid Association - February 27, 2019 Category: Endocrinology Tags: Thyroid Source Type: research

An independent comparison of the Afirma genomic sequencing classifier (GSC) and gene expression classifier (GEC) for cytologically indeterminate thyroid nodules.
Authors: Angell TE, Heller HT, Cibas E, Barletta J, Kim MI, Krane JF, Marqusee E Abstract BACKGROUND: For thyroid nodules with indeterminate cytology, the Afirma Gene Expression Classifier (GEC) identified benign nodules to reduce diagnostic surgery, though many nodules classified as suspicious still proved histopathologically benign. The current Afirma Genomic Sequencing Classifier (GSC) demonstrated improved specificity, suggesting more nodules would have a benign result (benign call rate [BCR]), but independent data are needed to confirm this in clinical practice. METHODS: Retrospective analysis of all Bethe...
Source: Thyroid : official journal of the American Thyroid Association - February 27, 2019 Category: Endocrinology Tags: Thyroid Source Type: research

Association of maternal thyroid function and thyroidal response to human chorionic gonadotropin with early fetal growth.
CONCLUSIONS: A low maternal thyroid function during the first trimester is associated with a modestly lower CRL. However, an impaired thyroidal response to hCG stimulation is associated with a considerably lower CRL for which effect estimates are in the range of, or even superseding those of well-known risk factors. These data can help to better identify pregnancies at high-risk of fetal growth restriction and adverse pregnancy or child outcomes. PMID: 30803392 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - February 27, 2019 Category: Endocrinology Tags: Thyroid Source Type: research

Image-guided Thyroid Ablation: Proposal for Standardization of Terminology and Reporting Criteria.
CONCLUSION: This proposal was drafted with the goal of providing guidance for standardized reporting of results in studies regarding image-guided thyroid ablations. We encourage adoption of this terminology worldwide anticipating that this will facilitate improved communication and understanding within the field and to stimulate further discussion on the topic over the next years. PMID: 30803397 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - February 27, 2019 Category: Endocrinology Tags: Thyroid Source Type: research

Treatment of toxic multinodular goiter: Comparison of radioiodine and long-term methimazole treatment.
Authors: Azizi F, Takyar M, Madreseh E, Amouzegar A Abstract OBJECTIVE: To compare the effectiveness and safety of long-term methimazole (MMI) and radioiodine in treatment of toxic multinodular goiter (TMNG). METHODS: In this randomized, parallel-group trial, 130 consecutive and untreated patients with TMNG, aged
Source: Thyroid : official journal of the American Thyroid Association - February 27, 2019 Category: Endocrinology Tags: Thyroid Source Type: research

The JAK/STAT3 and NF- κB signaling pathways regulate cancer stem cell properties in anaplastic thyroid cancer cells.
Conclusions: These results suggest that JAK/STAT3 and NF-κB signals play important roles in ATC-CSCs. Targeting these signaling pathways may be a promising approach to treat ATC. PMID: 30784360 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - February 21, 2019 Category: Endocrinology Tags: Thyroid Source Type: research

The primary cilium in the human thyrocyte: changes in frequency and length in relation to the functional pathology of the thyroid gland.
CONCLUSIONS: Our results suggest a direct relationship between ciliogenesis and both follicle activity and tissue heterogeneity in the functional pathology of the thyroid gland. PMID: 30767621 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - February 17, 2019 Category: Endocrinology Tags: Thyroid Source Type: research

Genetic and pharmacological targeting of transcriptional repression in resistance to thyroid hormone alpha.
Conclusions These studies indicate treatment with SAHA is unlikely to improve the skeletal manifestations of RTHα. Nevertheless, the findings (i) confirm that TRα1 has a critical role in the regulation of skeletal development and adult bone mass, (ii) suggest a physiological role for alternative co-repressors that interact with TR in skeletal cells, and (iii) demonstrate a novel role for NCoR1 in the regulation of adult bone mass and strength. PMID: 30760120 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - February 16, 2019 Category: Endocrinology Tags: Thyroid Source Type: research

The non-thyroidal illness syndrome in critically ill children: prognostic value and impact of nutritional management.
This study investigated the prognostic value of NTI, the impact of late-PN on NTI, and whether such impact explains or counteracts the outcome benefit of late-PN in critically ill children. METHODS: This pre-planned secondary-analysis of the PEPaNIC-RCT quantified serum TSH, total T4, T3 and rT3 concentrations in 982 patients upon PICU-admission versus 64 matched healthy children, and in 772 propensity score-matched early-PN and late-PN patients upon-admission and at day 3 or last PICU-day for shorter PICU-stay. Associations between thyroid-hormone concentrations upon-admission and outcome, as well as impact of late-PN...
Source: Thyroid : official journal of the American Thyroid Association - February 16, 2019 Category: Endocrinology Tags: Thyroid Source Type: research

Poorly differentiated carcinoma of the thyroid gland: Current status and future prospects.
CONCLUSIONS: These new insights into the clinico-pathological and molecular characteristics of PDTC, together with further advancement in ultra deep sequencing technologies, will be conducive in narrowing the focus in order to develop novel targeted therapies and improve the outcomes in PDTC patients. PMID: 30747050 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - February 14, 2019 Category: Endocrinology Tags: Thyroid Source Type: research

Microsatellite Instability Occurs in a Subset of Follicular Thyroid Cancers.
CONCLUSIONS: Based on these data, we estimate that the overall prevalence of MSI in FTC is 2.5%, and MSI is either entirely absent or rare in other histology subtypes of thyroid carcinoma. These findings highlight the importance of testing for MSI in follicular thyroid cancer. . PMID: 30747051 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - February 14, 2019 Category: Endocrinology Tags: Thyroid Source Type: research

Disruption of the pituitary circadian clock induced by hypothyroidism and hyperthyroidism: consequences on daily pituitary hormone expression profiles.
CONCLUSION: Taken together, the data demonstrated that hypo- and hyperthyroidism alter circadian clock gene expression in the anterior pituitary. Thus, suggesting that T3 plays an important role in the regulation of pituitary gland homeostasis, which could ultimately influence the rhythmic synthesis and/or secretion of all the anterior pituitary hormones. PMID: 30747053 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - February 14, 2019 Category: Endocrinology Tags: Thyroid Source Type: research

Primary Malignant Thyroid Teratoma: An Institutional Experience.
Authors: Ting J, Bell D, Ahmed S, Ying A, Waguespack SG, Tu SM, Weber R, Zafereo M Abstract BACKGROUND: Primary malignant thyroid teratomas are very rare tumors (fewer than 35 previously reported cases in the literature) typically affecting young adult women. While prognosis is poor, there have been some reports of successful treatment regimens. Four cases treated successfully are reported, and a review of the existing literature is provided. PATIENT FINDINGS: Medical records of four patients with histopathologically confirmed malignant thyroid teratomas treated at the University of Texas MD Anderson Cancer Cen...
Source: Thyroid : official journal of the American Thyroid Association - February 14, 2019 Category: Endocrinology Tags: Thyroid Source Type: research

Correction to: Longitudinal Characterization of Autoantibodies to the Thyrotropin Receptor (TRAb) During Alemtuzumab Therapy: Evidence that TRAb May Precede Thyroid Dysfunction by Many Years by Muller I, Willis M, Healy S, Nasser T, Loveless S, Butterworth S, Zhang L, Draman MS, Taylor PN, Robertson N, Dayan CM, and Ludgate ME. Thyroid 2018;28:1682-1693. DOI: 10.1089/thy.2018.0232.
Authors: PMID: 30759053 [PubMed - in process] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - February 14, 2019 Category: Endocrinology Tags: Thyroid Source Type: research

Pregnancy week specific reference ranges for TSH and free T4 in the North Denmark Region Pregnancy Cohort.
CONCLUSIONS: Results corroborate dynamic week specific changes in maternal TSH in early pregnancy. The use of uniform lower and upper reference range for TSH in early pregnancy may be too simple. PMID: 30734656 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - February 10, 2019 Category: Endocrinology Tags: Thyroid Source Type: research

Resolution of Hypothyroidism Restores Cold Induced Thermogenesis in Humans.
Authors: Maushart CI, Loeliger R, Gashi G, Christ-Crain M, Betz MJ Abstract Objective Hypothyroidism is a frequent endocrine disorder with common symptoms of increased cold sensitivity and unintended weight gain, indicating changes in energy expenditure (EE) and response to cold exposure. Thyroid hormones (TH) play an important role for proper function of brown adipose tissue (BAT) and cold induced thermogenesis (CIT) in rodents, but the role of hypothyroidism on CIT in humans is uncertain. Methods This was a prospective observational study. We recruited 42 patients presenting with subclinical or overt hypothyroidi...
Source: Thyroid : official journal of the American Thyroid Association - February 7, 2019 Category: Endocrinology Tags: Thyroid Source Type: research

Basic fibroblast growth factor induces adipogenesis in orbital fibroblasts; implication for the pathogenesis of graves' orbitopathy.
CONCLUSION: bFGF induces adipogenesis in orbital fibroblasts and as such may contribute to GO. The additive effect of bFGF and PDGF-BB on adipogenesis along with the observed inhibitory effects of dasatinib and nintedanib point at independent receptor mediated effects. This supports the hypothesis that multitarget directed therapy might be more efficient in the treatment of GO. PMID: 30724135 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - February 7, 2019 Category: Endocrinology Tags: Thyroid Source Type: research

Understanding pathways to the diagnosis of thyroid cancer - are there ways we can reduce over-diagnosis?
Authors: Rahman S, McLeod DSA, Pandeya N, Neale RE, Bain C, Baade PD, Youl P, Jordan SJ Abstract BACKGROUND: The incidence of thyroid cancer has rapidly increased and ecological evidence suggests this is due in some part, to over-diagnosis. Understanding pathways to diagnosis could help determine whether unnecessary diagnosis can be avoided. METHODS: We recruited a population-based sample (n=1007) of thyroid cancer patients diagnosed between July 2013 and August 2016 from Queensland, Australia (response rate 67%). We used information from structured telephone interviews to describe diagnostic pathways for thyro...
Source: Thyroid : official journal of the American Thyroid Association - February 2, 2019 Category: Endocrinology Tags: Thyroid Source Type: research

Comment about "Effects of Radioactive Iodine Therapy on Ovarian Reserve: A Prospective Pilot Study" by Evranos et al.
Comment about "Effects of Radioactive Iodine Therapy on Ovarian Reserve: A Prospective Pilot Study" by Evranos et al. Thyroid. 2019 Jan 31;: Authors: Yaish I, Azem F, Tordjman KM Abstract N/A. PMID: 30700207 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - February 2, 2019 Category: Endocrinology Tags: Thyroid Source Type: research

Thyroid function reference values in healthy iodine-sufficient pregnant women and influence of thyroid nodules on thyroid-stimulating hormone and free thyroxine values.
Authors: Ollero MD, Toni M, Pineda JJ, Martínez JP, Espada M, Anda E Abstract Background Thyroid function assessment in pregnancy requires specific reference intervals stratified by gestational age and according to each laboratory method. Thyroid nodules may influence thyroid function of pregnant women. Our aims were to define the reference values of thyroid-stimulating hormone (TSH) and free thyroxine (FT4) in the three pregnancy trimesters in iodine-sufficient pregnant women, and to analyze the influence of thyroid nodules on thyroid function during pregnancy. Methods This is a prospective, longitudinal st...
Source: Thyroid : official journal of the American Thyroid Association - January 31, 2019 Category: Endocrinology Tags: Thyroid Source Type: research

Shift of reference values for thyroid volume by ultrasound in 8-13-year-old children with sufficient iodine intake in China.
Authors: Chen W, Zhang Q, Wu Y, Wang W, Wang X, Pearce EN, Tan L, Shen J, Zhang W Abstract BACKGROUND: The iodine nutritional status of the Chinese population has been greatly improved in recent years. Therefore, the reference values for thyroid volume (Tvol) in children with sufficient iodine intake need to be updated. The study aimed to update the reference values for Tvol in children with sufficient iodine intake, in order to define goiter in the context of sustained iodine sufficiency. METHODS: A cross-sectional study was conducted in children with sufficient iodine intake in China. Twice repeated 24-h urin...
Source: Thyroid : official journal of the American Thyroid Association - January 31, 2019 Category: Endocrinology Tags: Thyroid Source Type: research

Knowledge of Thyroid Eye Disease in Graves' Disease Patients With and Without Orbitopathy.
Authors: Edmunds MR, Boelaert K Abstract Background Thyroid Eye Disease (TED) develops in around 25% of those with Graves' Disease (GD). Patients with TED may present late to ophthalmologists, when debilitating orbital inflammatory changes have already occurred. The reasons for this are multifactorial, but poor knowledge of TED in GD patients may be contributory. We aimed to assess the knowledge of TED in those with established TED, GD without orbitopathy and control subjects. Methods A validated, anonymised questionnaire, with 20 knowledge-based questions, was prospectively completed by 100 GD patients, 100 TED pa...
Source: Thyroid : official journal of the American Thyroid Association - January 30, 2019 Category: Endocrinology Tags: Thyroid Source Type: research

Two Mutations in Thyroid Hormone Receptor Beta Gene (P453A and C36Y) in a Family with Resistance to Thyroid Hormone with Comorbid Myotonic Dystrophy.
Authors: Takeda K, Nemoto KI, Hayashi Y, Yamamoto M, Sakuta R, Kimura T, Noto H Abstract The co-occurrence of resistance to thyroid hormone beta (RTHß) and myotonic dystrophy type 1 (DM1) was observed in a Japanese family. Two mutations, P453A and C36Y, were identified in thyroid hormone receptor beta gene (THRB). Whereas family members with THRB-P453A exhibited RTHß, two members with THRB-C36Y but without THRB-P453A had normal thyroid function. Two members, one with RTHß and the other without, had a triplet expansion in DMPK (dystrophia myotonia protein kinase gene), a hallmark of DM1. The member...
Source: Thyroid : official journal of the American Thyroid Association - January 25, 2019 Category: Endocrinology Tags: Thyroid Source Type: research

Correction to: Diagnostic Performance of Ultrasound-Based Risk-Stratification Systems for Thyroid Nodules: Comparison of the 2015 American Thyroid Association Guidelines with the 2016 Korean Thyroid Association/Korean Society of Thyroid Radiology and 2017 American College of Radiology Guidelines Ha EJ, Na DG, Moon W-J, Lee YH, and Choi N Thyroid 2018;28:1532-1537. DOI: 10.1089/thy.2018.0094.
Authors: PMID: 30673501 [PubMed - in process] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - January 25, 2019 Category: Endocrinology Tags: Thyroid Source Type: research

Leslie J. De Groot (September 20, 1928-October 3, 2018).
Authors: PMID: 30673503 [PubMed - in process] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - January 25, 2019 Category: Endocrinology Tags: Thyroid Source Type: research

Impaired quality of life after radioiodine therapy compared with antithyroid drugs or surgical treatment for Graves' hyperthyroidism. A long-term follow-up with ThyPRO and SF-36.
CONCLUSIONS: Graves´ disease is associated with a lower QoL many years after treatment compared to the general population. In a previous, small RCT we did not show any difference in patient satisfaction years after ATD, RAI or surgery. We now report that in a large non-randomized cohort, patients who received RAI had adverse scores on ThyPRO and SF-36. These findings in a Swedish population are limited by comparison to normative data from Denmark, by older age and possibly a more prolonged course in those patients who received radioiodine, and a lack of information regarding thyroid status at the time of evaluation. ...
Source: Thyroid : official journal of the American Thyroid Association - January 24, 2019 Category: Endocrinology Tags: Thyroid Source Type: research

Risk Haplotypes Uniquely Associated with Radioiodine Refractory Thyroid Cancer Patients of High African Ancestry.
Authors: Hurst Z, Liyanarachchi S, He H, Brock P, Sipos JA, Nabhan F, Kebebew E, Green P, Cote GJ, Sherman SI, Walker CJ, Chang YS, Xue S, Hollingsworth B, Li W, Genutis L, Menq E, de la Chapelle A, Jhiang SM Abstract BACKGROUND: Thyroid cancer patients with radioiodine refractory (RAI-R) disease, resulting from insufficient RAI delivery and/or RAI resistance, have increased mortality and limited treatment options. To date, studies have largely focused on tumor mutations associated with different stages of disease, which could provide prognostic value for RAI-R disease. We hypothesize that germline variants contrib...
Source: Thyroid : official journal of the American Thyroid Association - January 20, 2019 Category: Endocrinology Tags: Thyroid Source Type: research

Thyroglobulin is markedly elevated in 6-24-month-old infants at both low and high iodine intakes and suggests a narrow optimal iodine intake range.
Authors: Farebrother J, Zimmermann M, Assey V, Castro MC, Cherkaoui M, Fingerhut R, Jia Q, Jukic T, Makokha A, San Luis TOL, Wegmuller R, Andersson M Abstract Background In areas of incomplete salt iodization coverage, infants and children aged 6-24-months weaning from breastmilk and receiving complementary foods are at risk of iodine deficiency. However, few data exist on the risk of excessive iodine intakes in this age group. Thyroglobulin (Tg) is a sensitive marker of iodine intake in school-age children and adults and may be used to estimate the optimal iodine intake range in infancy. Objective To assess the as...
Source: Thyroid : official journal of the American Thyroid Association - January 18, 2019 Category: Endocrinology Tags: Thyroid Source Type: research

Metabolic Obesity Phenotypes and Thyroid Cancer Risk: A Cohort Study.
Authors: Kwon H, Chang Y, Cho A, Ahn J, Park SE, Park CY, Lee WY, Oh KW, Park SW, Shin H, Ryu S, Rhee EJ Abstract BACKGROUND: No cohort studies have evaluated the effect of obesity on the incidence of thyroid cancer according to metabolic health status. Therefore, we examined the association of body mass index (BMI) and metabolic health status with thyroid cancer risk. METHODS: We performed a cohort study involving 255,051 metabolically healthy (MH) and metabolically unhealthy (MUH) adults free of thyroid cancer at baseline who were followed for a median of 5.3 years. A parametric proportional hazard model was ...
Source: Thyroid : official journal of the American Thyroid Association - January 18, 2019 Category: Endocrinology Tags: Thyroid Source Type: research

Duration of hyperthyroidism and lack of sufficient treatment are associated with increased cardiovascular risk.
Authors: Lillevang-Johansen M, Abrahamsen B, Jørgensen HL, Brix TH, Hegedus L Abstract IMPORTANCE: Cardiovascular disease remains the most prevalent cause of death in hyperthyroidism. However, the impact on cardiovascular events of varying thyroid status and that of treatment remain unclarified. OBJECTIVE: To investigate the association between hyperthyroidism and cardiovascular events in treated and untreated hyperthyroid individuals, as well as exploring the impact of cumulative periods of hyperthyroidism, as a proxy for undertreatment, on cardiovascular events. DESIGN: A case-control study nested ...
Source: Thyroid : official journal of the American Thyroid Association - January 18, 2019 Category: Endocrinology Tags: Thyroid Source Type: research

GLIS Rearrangement is a Genomic Hallmark of Hyalinizing Trabecular Tumor of the Thyroid Gland.
CONCLUSIONS: In this study, we demonstrate that GLIS rearrangements, and particularly PAX8-GLIS3 are highly prevalent in HTT, but not in papillary thyroid carcinomas. The fusions lead to overexpression of GLIS, upregulation of extracellular matrix genes, and deposition of collagens, which is a characteristic histopathologic feature of HTT. Due to unique genetic mechanisms and an indolent behavior, we propose to rename this tumor as "GLIS-rearranged hyalinizing trabecular adenoma." PMID: 30648929 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - January 18, 2019 Category: Endocrinology Tags: Thyroid Source Type: research

Increased Risk of Antithyroid Drugs Agranulocytosis Associated with Amiodarone-induced Thyrotoxicosis: a Population-based Cohort Study.
Authors: Gershinsky M, Saliba W, Lavi I, Shapira C, Gronich N Abstract OBJECTIVE: Agranulocytosis occurs in 0.2-0.5% of patients treated with the antithyroid drugs (ATDs) methimazole and propylthiouracil. Our objective was to evaluate the risk of ATD-related agranulocytosis in patients with amiodarone-induced thyrotoxicosis, and to compare it with the agranulocytosis risk in patients with thyrotoxicosis due to other etiologies, treated with ATDs. DESIGN: Retrospective cohort study Setting: Clalit Health Services database Participants: 14,781 adult patients with thyrotoxicosis, newly treated with an ATD between ...
Source: Thyroid : official journal of the American Thyroid Association - January 18, 2019 Category: Endocrinology Tags: Thyroid Source Type: research

Regulation of Foxe1 by TSH and TGF β depends on the interplay between thyroid-specific, CREB and SMAD transcription factors.
CONCLUSIONS: We show that Foxe1 is the final target of TSH/cAMP and TGFβ regulation that mediates expression of thyroid differentiation genes, and provide evidence of an interplay between CRE-binding proteins, thyroid transcription factors and Smad proteins in its regulation. Thus, Foxe1 plays an important role in the complex transcriptional network that regulates thyroid follicular cell differentiation. PMID: 30652527 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - January 18, 2019 Category: Endocrinology Tags: Thyroid Source Type: research

Hypothyroidism in Nonalcoholic Fatty Liver Disease: Causative Factor or Innocent Bystander?
Authors: Bril F, Kadiyala S, Cusi K Abstract Not required per guidelines. PMID: 30652529 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - January 18, 2019 Category: Endocrinology Tags: Thyroid Source Type: research