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Disulfide bonds of thyroid peroxidase are critical elements for subcellular localization, proteasome-dependent degradation, and enzyme activity
CONCLUSIONS: All 12 disulfide bonds play an important role in the activity of TPO. Furthermore, the mutations lead to misfolding, degradation, and membrane insertion.PMID:38482822 | DOI:10.1089/thy.2023.0514 (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - March 14, 2024 Category: Endocrinology Authors: Hajime Iwasaki Hirotsugu Suwanai Fumiyoshi Yakou Hiroyuki Sakai Keitaro Ishii Natsuko Hara Ashley M Buckle Kohsuke Kanekura Tamami Miyagi Satoshi Narumi Ryo Suzuki Source Type: research

Decision Regret Following the Choice of Surgery or Active Surveillance for Small, Low-Risk Papillary Thyroid Cancer: A Prospective Cohort Study
CONCLUSIONS: In this study of patients with small, low risk PTC, the mean level of decision regret pertaining to the initial disease management choice was relatively low after one year and it did not differ significantly for respondents who chose AS or surgery.PMID:38481111 | DOI:10.1089/thy.2023.0634 (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - March 14, 2024 Category: Endocrinology Authors: Anna M Sawka Sangeet Ghai Lorne Rotstein Jonathan C Irish Jesse D Pasternak Eric Monteiro Janet Chung Afshan Zahedi Jie Su Wei Xu Jennifer Jones Amiram Gafni Nancy Baxter David P Goldstein Source Type: research

Molecular Testing for Bethesda III Thyroid nodules: Trends in Implementation, Cytopathology Call Rates, Surgery Rates, and Malignancy Yield at a Single Institution
Conclusion The use of MT increased across the institution over the study period, with the largest increase seen after a dedicated pass for MT was routinely collected. This increased availability of MT may have led to an unintended increase in the rates of BIII lesions, MT utilization, and surgery for benign nodules. Physicians who use MT should be aware of potential consequences of its adoption in order to appropriately counsel patients.PMID:38468547 | DOI:10.1089/thy.2023.0664 (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - March 12, 2024 Category: Endocrinology Authors: Mason Stillman Eric J Kuo Rachel Liou Abdullah Almuqate Renu Virk James A Lee Jennifer H Kuo Catherine M McManus Source Type: research

Identification of P21 (CDKN1A) Activated Kinase 4 as a susceptibility gene for Familial Non-medullary Thyroid Carcinoma
CONCLUSIONS: Our study identified PAK4: c.T1250C: p.I417T as a potential susceptibility gene for FNMTC. The study concludes that the mutant form of PAK4 exhibits stronger oncogenic functions, suggesting its potential as a novel diagnostic molecular marker for FNMTC.PMID:38411500 | DOI:10.1089/thy.2023.0564 (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - February 27, 2024 Category: Endocrinology Authors: Yu-Jia Jiang Yun Xia Yixuan Hu Zhuojun Han Anyuan Guo Tao Huang Source Type: research