Disulfide bonds of thyroid peroxidase are critical elements for subcellular localization, proteasome-dependent degradation, and enzyme activity

CONCLUSIONS: All 12 disulfide bonds play an important role in the activity of TPO. Furthermore, the mutations lead to misfolding, degradation, and membrane insertion.PMID:38482822 | DOI:10.1089/thy.2023.0514

Source: Thyroid : official journal of the American Thyroid Association - March 14, 2024 Category: Endocrinology Authors: Hajime Iwasaki Hirotsugu Suwanai Fumiyoshi Yakou Hiroyuki Sakai Keitaro Ishii Natsuko Hara Ashley M Buckle Kohsuke Kanekura Tamami Miyagi Satoshi Narumi Ryo Suzuki Source Type: research