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Fear of Cancer Recurrence in Differentiated Thyroid Cancer Survivors - A Systematic Review
CONCLUSION: FCR is common in thyroid cancer survivors but significant heterogeneity in the current evidence base limits assessment of incidence, severity or risk factors. There is a need to use validated tools to assess FCR in both research and clinical contexts. Reliable assessment of FCR may permit routine assessment of FCR in clinical practice and allow interventions to be prospectively evaluated to optimise the holistic well-being of thyroid cancer survivors.PMID:38368547 | DOI:10.1089/thy.2023.0642 (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - February 18, 2024 Category: Endocrinology Authors: Jacob Hampton Ahmad Alam Nicholas Zdenkowski Christopher Rowe Elizabeth Fradgley Christine O'Neill Source Type: research

Clinical evaluation of an Artificial Intelligence-based decision support system for the diagnosis and ACR TI-RADS classification of thyroid nodules
CONCLUSION: The use of an AI-based DSS was associated with an overall improvement in the diagnostic efficacy of ultrasound imaging, based on the AUROC, as well as an increase in sensitivity, specificity, the negative and positive predictive value, and diagnostic accuracy. There was also a reduction in interobserver variability and an increase in the degree of concordance with the use of Al. Al reclassified more than half of the nodules with intermediate ACR TI-RADS into lower risk categories.PMID:38368560 | DOI:10.1089/thy.2023.0603 (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - February 18, 2024 Category: Endocrinology Authors: Pablo Fernandez-Velasco Paloma P érez López Beatriz Torres Esther Delgado Daniel de Luis Gonzalo Diaz-Soto Source Type: research

Reassessing Selenium for the Management of Hashimoto's Thyroiditis: the Selini* shines bright for AIT patients
Thyroid. 2024 Feb 18. doi: 10.1089/thy.2024.0078. Online ahead of print.ABSTRACTNA.PMID:38368561 | DOI:10.1089/thy.2024.0078 (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - February 18, 2024 Category: Endocrinology Authors: Leonidas H Duntas Source Type: research

Effects of levothyroxine treatment on fertility and pregnancy outcomes in subclinical hypothyroidism: a systematic review and meta-analysis of randomized controlled trials
CONCLUSIONS: Pre-conceptional levothyroxine treatment does not improve fertility or decrease the incidence of miscarriages. However, further well-designed studies are needed for pre-conceptional treatment, especially in TSH >4.0 mU/L. Levothyroxine treatment during pregnancy had a positive effect on preterm birth; nevertheless, this was only applicable to subclinical hypothyroidism with TSH >4.0 mU/L.PMID:38368537 | DOI:10.1089/thy.2023.0546 (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - February 18, 2024 Category: Endocrinology Authors: Akiko Sankoda Hitomi Suzuki Misa Imaizumi Ai Yoshihara Sakiko Kobayashi Miyuki Katai Katsuhiko Hamada Yoh Hidaka Aya Yoshihara Hannah Nakamura Sumihisa Kubota Maiko Kakita-Kobayashi Akira Iwase Takashi Sugiyama Erika Ota Naoko Arata Source Type: research

Patients' persistent symptoms, clinician demographics and geo-economic factors are associated with choice of therapy for hypothyroidism by European thyroid specialists: The "THESIS"* collaboration (* T reatment of H ypothyroidism in Europe by S pecialists, an I nternational S urvey)
CONCLUSIONS: The perception of patients' dissatisfaction reported by physicians seems lower than that described by hypothyroid patients in previous surveys. LT4+LT3 treatment is used frequently by thyroid specialists in Europe for persistent hypothyroid-like symptoms even if they generally attribute such symptoms to non-endocrine causes and despite the evidence of non-superiority of the combined over the LT4 therapy. Pressure by dissatisfied patients on their physicians for LT3-containing treatments is a likely explanation. The association of the therapeutic choices with the clinician demographic characteristics and geo-ec...
Source: Thyroid : official journal of the American Thyroid Association - February 18, 2024 Category: Endocrinology Authors: Roberto Attanasio Milo š Žarković Enrico Papini Endre V Nagy Roberto Negro Petros Perros Ersin Akarsu Maria Alevizaki G öksun Ayvaz Tomasz Bednarczuk Biljana Beleslin Eszter Berta Miklos Bodor Anna Maria Borissova Mihail Boyanov Camille Buffet Maria-C Source Type: research

A phase II study of encorafenib in combination with binimetinib in patients with metastatic BRAF-mutated thyroid cancer in Japan
CONCLUSIONS: Treatment with encorafenib plus binimetinib met the primary endpoint criteria and demonstrated clinical benefit in patients with BRAFV600E-mutated thyroid cancer regardless of its histological type, such as DTC or ATC, with no new safety concerns identified. Encorafenib plus binimetinib could thus be a new treatment option for BRAF V600-mutated thyroid cancer.PMID:38343359 | DOI:10.1089/thy.2023.0547 (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - February 12, 2024 Category: Endocrinology Authors: Makoto Tahara Naomi Kiyota Hiroo Imai Shunji Takahashi Akihiro Nishiyama Shingo Tamura Yasushi Shimizu Shigenori Kadowaki Ken-Ichi Ito Masahiro Toyoshima Yoshinori Hirashima Shinji Ueno Iwao Sugitani Source Type: research

Why did the rapid increase of reflex molecular testing of indeterminate FNA cytologies in the USA not impact thyroidectomy rates? What is the lesson to be learned?
Thyroid. 2024 Feb 12. doi: 10.1089/thy.2024.0042. Online ahead of print.ABSTRACTnone.PMID:38343362 | DOI:10.1089/thy.2024.0042 (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - February 12, 2024 Category: Endocrinology Authors: Ralf Paschke Source Type: research