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Social Vulnerability Association with Thyroid Cancer Disparities in the United States
CONCLUSIONS: Our results show significant detriments in TC care & prognosis in the US with increasing overall social vulnerability while identifying which SDoH quantifiably contribute more to disparities in interrelational, real-world-like contexts.PMID:38069566 | DOI:10.1089/thy.2023.0370 (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - December 9, 2023 Category: Endocrinology Authors: David Fei-Zhang Rhea Verma Ryuji Arimoto Amelia S Lawrence Daniel C Chelius Urjeet A Patel Stephanie S Smith Anthony M Sheyn Jeffrey C Rastatter Source Type: research

The Combined Effect of Immune Checkpoint Inhibitors and Tyrosine Kinase Inhibitors on Thyroid Function
Thyroid. 2023 Dec 9. doi: 10.1089/thy.2023.0542. Online ahead of print.ABSTRACTSee updated abstract in revised manuscript.PMID:38069567 | DOI:10.1089/thy.2023.0542 (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - December 9, 2023 Category: Endocrinology Authors: Karen Tsai Huiyan Ma Tom Zhe Liang Yan Xing Samuel Chung Tanya Dorff Diana Bell Melissa G Lechner Source Type: research

Increased progression-free survival with cabozantinib versus placebo in patients with radioiodine-refractory differentiated thyroid cancer irrespective of prior VEGFR-targeted therapy and tumor histology: a subgroup analysis of the COSMIC-311 study
CONCLUSIONS: Results indicate that cabozantinib benefits patients with radioiodine-refractory DTC, regardless of prior lenvatinib or sorafenib treatments or histology.PMID:38062732 | DOI:10.1089/thy.2023.0463 (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - December 8, 2023 Category: Endocrinology Authors: Jaume Capdevila Jolanta Krajewska Jorge Hernando Bruce Robinson Steven I Sherman Barbara Jarzab Chia-Chi Lin Fernanda Vaisman Ana Oliveira Hoff Erika Hitre Daniel Bowles Denise Williamson Roman Levytskyy Jennifer W Oliver Bhumsuk Keam Marcia Brose Source Type: research

GLP-1 receptor signaling has different effects on the perikarya and axons of the hypophysiotropic thyrotropin-releasing hormone synthesizing neurons in male mice
CONCLUSIONS: Our results indicate that GLP-1R activation has direct stimulatory effect on TRH neurons in the PVN, but the activation of GLP-1R may also inhibit TRH neurons by facilitating their inhibitory inputs or by inhibiting the axon terminals of these cells in the median eminence. The innervation of TRH neurons by GLP-1 neurons suggests that TRH neurons might be influenced by both circulating GLP-1 and by GLP-1 neurons of the nucleus tractus solitarii. The lack of GLP-1R agonist induced regulation of TRH neurons in vivo suggests that the HPT axis does not mediate the GLP-1 receptor agonist-induced weight loss.PMID:380...
Source: Thyroid : official journal of the American Thyroid Association - December 8, 2023 Category: Endocrinology Authors: Yvette Ruska Zoltan Peterfi Anett Szilv ásy-Szabó D óra Kővári Erik Hrabovszky Be áta Dorogházi Bal ázs Gereben Blanka T óth Magdalini Matziari Gabor Wittmann Csaba Fekete Source Type: research

Clinical and Surgical Year in Review
Thyroid. 2023 Dec 7. doi: 10.1089/thy.2023.0601. Online ahead of print.ABSTRACTn/a.PMID:38062755 | DOI:10.1089/thy.2023.0601 (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - December 8, 2023 Category: Endocrinology Authors: Whitney Goldner Catherine Sinclair Source Type: research

Presumed Pathogenic Germline and Somatic Variants in African American Thyroid Cancer
CONCLUSION: In this cohort, most AA-NMTC patients exhibit favorable outcomes after therapeutic intervention given at cancer centers, suggesting that healthcare disparity is the major contributor for worse prognoses among AA-NMTC patients. Nevertheless, the clinical impact of PPGVs that might facilitate acquisition of TP53 tumor mutations, and/or PPGVs that predispose individuals to adverse cardiovascular events which could be exacerbated by therapy-induced cardiotoxicity, need to be further explored. Integrated analysis of PPGV/PPSV profiles among NMTC patients with different stages of disease may help to identify NMTC pat...
Source: Thyroid : official journal of the American Thyroid Association - December 8, 2023 Category: Endocrinology Authors: Zachary A Hurst Sandya Liyanarachchi Pamela Brock Huiling He Fadi Nabhan Colleen Veloski Amanda E Toland Matthew D Ringel Sissy M Jhiang Source Type: research

PDPR gene variants predisposing to papillary thyroid cancer
CONCLUSIONS: Our finding of novel truncating germline variants in PDPR in family Q and additional cohorts suggests a role for PDPR loss in PTC predisposition. Also, somatic and RNA-sequencing from the Thyroid carcinoma (Firehouse Legacy) data showed that PDPR gene expression is much lower in thyroid cancer tumor tissue compared to matching normal tissue. Thus, PDPR appears to have a loss of function effect on thyroid cancer tumorigenesis.PMID:38062777 | DOI:10.1089/thy.2023.0560 (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - December 8, 2023 Category: Endocrinology Authors: Pamela Brock Myriam S évigny Sandya Liyanarachchi Daniel F Comiskey Wei Li Saila Saarinen Ayse Selen Yilmaz Anni Irmeli I Nieminen Matthew D Ringel Paivi Peltomaki Saara Ollila Taina Tuulikki Nieminen Source Type: research

Acknowledgment of Reviewers 2023
Thyroid. 2023 Dec;33(12):1498-1500. doi: 10.1089/thy.2023.29166.ack.NO ABSTRACTPMID:38064573 | DOI:10.1089/thy.2023.29166.ack (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - December 8, 2023 Category: Endocrinology Source Type: research