Identification of P21 (CDKN1A) Activated Kinase 4 as a susceptibility gene for Familial Non-medullary Thyroid Carcinoma

CONCLUSIONS: Our study identified PAK4: c.T1250C: p.I417T as a potential susceptibility gene for FNMTC. The study concludes that the mutant form of PAK4 exhibits stronger oncogenic functions, suggesting its potential as a novel diagnostic molecular marker for FNMTC.PMID:38411500 | DOI:10.1089/thy.2023.0564
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Authors: Source Type: research