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A phase II study of encorafenib in combination with binimetinib in patients with metastatic BRAF-mutated thyroid cancer in Japan
CONCLUSIONS: Treatment with encorafenib plus binimetinib met the primary endpoint criteria and demonstrated clinical benefit in patients with BRAFV600E-mutated thyroid cancer regardless of its histological type, such as DTC or ATC, with no new safety concerns identified. Encorafenib plus binimetinib could thus be a new treatment option for BRAF V600-mutated thyroid cancer.PMID:38343359 | DOI:10.1089/thy.2023.0547 (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - February 12, 2024 Category: Endocrinology Authors: Makoto Tahara Naomi Kiyota Hiroo Imai Shunji Takahashi Akihiro Nishiyama Shingo Tamura Yasushi Shimizu Shigenori Kadowaki Ken-Ichi Ito Masahiro Toyoshima Yoshinori Hirashima Shinji Ueno Iwao Sugitani Source Type: research

Why did the rapid increase of reflex molecular testing of indeterminate FNA cytologies in the USA not impact thyroidectomy rates? What is the lesson to be learned?
Thyroid. 2024 Feb 12. doi: 10.1089/thy.2024.0042. Online ahead of print.ABSTRACTnone.PMID:38343362 | DOI:10.1089/thy.2024.0042 (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - February 12, 2024 Category: Endocrinology Authors: Ralf Paschke Source Type: research

Informative response to Fitzgerald et al. re: "Thyroid Stimulating Hormone and Thyroid Hormones (Triiodothyronine and Thyroxine): An American Thyroid Association-Commissioned Review of Current Clinical and Laboratory Status"
Thyroid. 2024 Feb 12. doi: 10.1089/thy.2024.0049. Online ahead of print.ABSTRACTNot required.PMID:38343366 | DOI:10.1089/thy.2024.0049 (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - February 12, 2024 Category: Endocrinology Authors: Stig Andersen Stine Linding Andersen Source Type: research

GLP-1 receptor agonists and thyroid cancer: a narrative review
CONCLUSIONS: Evidence from randomized controlled trials indicates occurrence of thyroid cancer is infrequent in individuals exposed to GLP-1 RA. Observational studies at higher risk of bias yield inconsistent results. Overall there is no conclusive evidence of elevated thyroid cancer risk. These findings can help clinicians when addressing patient's concerns about a potential yet unproven link between GLP-1 RA therapy and thyroid cancer. .PMID:38343381 | DOI:10.1089/thy.2023.0530 (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - February 12, 2024 Category: Endocrinology Authors: Ana Elena Espinosa De Ycaza Juan P Brito Rozalina McCoy Hui Shao Naykky M Singh Ospina Source Type: research

Clinical Features and Outcomes of Myxedema Coma in Patients Hospitalized for Hypothyroidism: Analysis of the United States National Inpatient Sample
CONCLUSION: In summary, myxedema coma remains a clinically significant diagnosis in the modern era, independently associated with high mortality and health care costs. This continued burden demonstrates a need for further efforts to prevent, identify, and optimize treatment for patients with myxedema coma.PMID:38279788 | DOI:10.1089/thy.2023.0559 (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - January 27, 2024 Category: Endocrinology Authors: Dennis H Chen Carolina R Hurtado Patrick W Chang Mariam Zakher Trevor E Angell Source Type: research

CHEK2 founder variants and thyroid cancer risk
CONCLUSIONS: Our analyses of unselected patients with NMTC suggest that CHEK2 variants c.1100del and c.470T>C/p.I157T have only a modest impact on thyroid cancer risk. These results provide important information for providers regarding the relatively low magnitude of thyroid cancer risk associated with these CHEK2 variants.PMID:38279823 | DOI:10.1089/thy.2023.0529 (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - January 27, 2024 Category: Endocrinology Authors: Pamela Brock Sandya Liyanarachchi Taina Tuulikki Nieminen Carlos Chan Wendy Kohlmann Leigh Anne Stout Song Yao Amanda La Greca Kirk E Jensen Jill Kolesar Bodour Salhia Pat Gulhati J Kevin Hicks Matthew D Ringel Source Type: research

A long-term study comparing the quality of life and psychological status of patients with highly suspicious thyroid nodules ≤ 1 cm undergoing active surveillance with those undergoing immediate surgery
CONCLUSION: Patients with highly suspicious sub-centimeter thyroid nodules who choose IS tend to experience a poorer long-term QoL compared to those who choose AS. Although the situation may improve over time, certain issues might persist, making AS a favorable option for these patients.PMID:38269424 | DOI:10.1089/thy.2023.0478 (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - January 25, 2024 Category: Endocrinology Authors: Chun-Hao Liu Hao Zhao Ying Lu Yu Xia Yue Cao Li-Yang Zhang Ya Zhao Luying Gao Yuewu Liu Hongfeng Liu Zi-Feng Kuang Shuzhou Liu Qian-Qian Shao Xiao-Yi Li Source Type: research