Analysis of Serum Free Thyroxine Concentrations in Healthy Term Neonates Underlines Need for Local and Laboratory-Specific Reference Interval: A Systematic Review and Meta-Analysis of Individual Participant Data
Conclusions: We conclude that our attempts at normalizing fT4 assay results were unsuccessful. Confounders related to our unsuccessful analysis may be assay related and/or biological. These findings have significant implications for patient care, since relying on RIs from literature may result in erroneous interpretation of results. Therefore, we strongly recommend to establish local RIs for accurate interpretation of serum fT4 concentrations in neonates.PMID:38563802 | DOI:10.1089/thy.2023.0562
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Authors: Peter Lauffer Charlotte A Heinen Annika W M Goorsenberg Arjan Malekzadeh Peter Henneman Annemieke C Heijboer Nitash Zwaveling-Soonawala Anita Boelen A S Paul van Trotsenburg Source Type: research
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