Predictive significance of FGFR4 p.G388R polymorphism in metastatic colorectal cancer patients receiving trifluridine/tipiracil (TAS-102) treatment

CONCLUSIONS: This phenotype/genotype investigation suggests that the FGFR4 p.G388R variant may serve as a new marker for identifying patients who are responsive to TAS-102. A mechanistic hypothesis is proposed to interpret these findings.PMID:38650006 | DOI:10.1186/s12967-024-05184-w

Source: Cancer Control - April 22, 2024 Category: Cancer & Oncology Authors: Alessandro Ottaiano Mariachiara Santorsola Monica Ianniello Anna Ceccarelli Marika Casillo Francesco Sabbatino Nadia Petrillo Marco Cascella Francesco Caraglia Carmine Picone Francesco Perri Roberto Sirica Silvia Zappavigna Guglielmo Nasti Giovanni Savare Source Type: research