Noise-Induced Hearing Loss: Updates on Molecular Targets and Potential Interventions
Neural Plast. 2021 Jul 6;2021:4784385. doi: 10.1155/2021/4784385. eCollection 2021.ABSTRACTNoise overexposure leads to hair cell loss, synaptic ribbon reduction, and auditory nerve deterioration, resulting in transient or permanent hearing loss depending on the exposure severity. Oxidative stress, inflammation, calcium overload, glutamate excitotoxicity, and energy metabolism disturbance are the main contributors to noise-induced hearing loss (NIHL) up to now. Gene variations are also identified as NIHL related. Glucocorticoid is the only approved medication for NIHL treatment. New pharmaceuticals targeting oxidative stres...
Source: Neural Plasticity - July 26, 2021 Category: Neurology Authors: Huanyu Mao Yan Chen Source Type: research

Autophagy: A Novel Horizon for Hair Cell Protection
Neural Plast. 2021 Jun 29;2021:5511010. doi: 10.1155/2021/5511010. eCollection 2021.ABSTRACTAs a general sensory disorder, hearing loss was a major concern worldwide. Autophagy is a common cellular reaction to stress that degrades cytoplasmic waste through the lysosome pathway. Autophagy not only plays major roles in maintaining intracellular homeostasis but is also involved in the development and pathogenesis of many diseases. In the auditory system, several studies revealed the link between autophagy and hearing protection. In this review, we aimed to establish the correlation between autophagy and hair cells (HCs) from ...
Source: Neural Plasticity - July 26, 2021 Category: Neurology Authors: Chang Liu Zhiwei Zheng Pengjun Wang Shuangba He Yingzi He Source Type: research

Global Research on Neuropathic Pain Rehabilitation over the Last 20 Years
Neural Plast. 2021 Jul 7;2021:5594512. doi: 10.1155/2021/5594512. eCollection 2021.ABSTRACTBACKGROUND: Neuropathic pain has long been a very popular and productive field of clinical research. Neuropathic pain is difficult to cure radically because of its complicated etiology and uncertain pathogenesis. As pain worsens and persists, pain recovery techniques become more important, and medication alone is insufficient. No summary of bibliometric studies on neuropathic pain rehabilitation is yet available. The purpose of the present study is to analyze in a systematic manner the trends of neuropathic pain rehabilitation resear...
Source: Neural Plasticity - July 26, 2021 Category: Neurology Authors: Xuan Su Hao-Yu Hu Chang Xu Source Type: research

Astrocytes in the Ventromedial Hypothalamus Involve Chronic Stress-Induced Anxiety and Bone Loss in Mice
This study not only advances our understanding of glial cell function but also provides a potential intervention target for chronic stress-induced anxiety and bone loss therapy.PMID:34306063 | PMC:PMC8282369 | DOI:10.1155/2021/7806370 (Source: Neural Plasticity)
Source: Neural Plasticity - July 26, 2021 Category: Neurology Authors: Yunhui Liu Jie Shao Dashuang Gao Lu Zhang Fan Yang Source Type: research

Low Back Pain Assessment Based on Alpha Oscillation Changes in Spontaneous Electroencephalogram (EEG)
Neural Plast. 2021 Jul 1;2021:8537437. doi: 10.1155/2021/8537437. eCollection 2021.ABSTRACTObjectively and accurately assessing pain in clinical settings is challenging. Previous studies showed that alpha oscillations of electroencephalogram data are correlated with subjective perceived pain. Based on this finding, this study is aimed at assessing chronic low back pain based on alpha oscillations. Multichannel electroencephalogram data were recorded from 27 subjects with chronic low back pain under the simple conditions of closing eyes or opening eyes. Spectral analyses were conducted to extract the alpha band responses, a...
Source: Neural Plasticity - July 26, 2021 Category: Neurology Authors: Li Feng Hanlei Li Hongyan Cui Xiaobo Xie Shengpu Xu Yong Hu Source Type: research

Inhibitory Control Deficits in Children with Tic Disorders Revealed by Object-Hit-and-Avoid Task
CONCLUSIONS: In children with tics (without comorbid ADHD), acting upon both targets and distractors suggests reduced ability to suppress responses to potential triggers for action. This may be related to increased sensorimotor noise or abnormal sensory gating.PMID:34306065 | PMC:PMC8270726 | DOI:10.1155/2021/8825091 (Source: Neural Plasticity)
Source: Neural Plasticity - July 26, 2021 Category: Neurology Authors: Nicholas Cothros Alex Medina Davide Martino Sean P Dukelow Rachel L Hawe Adam Kirton Christos Ganos Elaheh Nosratmirshekarlou Tamara Pringsheim Source Type: research

Noise-Induced Hearing Loss: Updates on Molecular Targets and Potential Interventions
Neural Plast. 2021 Jul 6;2021:4784385. doi: 10.1155/2021/4784385. eCollection 2021.ABSTRACTNoise overexposure leads to hair cell loss, synaptic ribbon reduction, and auditory nerve deterioration, resulting in transient or permanent hearing loss depending on the exposure severity. Oxidative stress, inflammation, calcium overload, glutamate excitotoxicity, and energy metabolism disturbance are the main contributors to noise-induced hearing loss (NIHL) up to now. Gene variations are also identified as NIHL related. Glucocorticoid is the only approved medication for NIHL treatment. New pharmaceuticals targeting oxidative stres...
Source: Neural Plasticity - July 26, 2021 Category: Neurology Authors: Huanyu Mao Yan Chen Source Type: research

Autophagy: A Novel Horizon for Hair Cell Protection
Neural Plast. 2021 Jun 29;2021:5511010. doi: 10.1155/2021/5511010. eCollection 2021.ABSTRACTAs a general sensory disorder, hearing loss was a major concern worldwide. Autophagy is a common cellular reaction to stress that degrades cytoplasmic waste through the lysosome pathway. Autophagy not only plays major roles in maintaining intracellular homeostasis but is also involved in the development and pathogenesis of many diseases. In the auditory system, several studies revealed the link between autophagy and hearing protection. In this review, we aimed to establish the correlation between autophagy and hair cells (HCs) from ...
Source: Neural Plasticity - July 26, 2021 Category: Neurology Authors: Chang Liu Zhiwei Zheng Pengjun Wang Shuangba He Yingzi He Source Type: research

Global Research on Neuropathic Pain Rehabilitation over the Last 20 Years
Neural Plast. 2021 Jul 7;2021:5594512. doi: 10.1155/2021/5594512. eCollection 2021.ABSTRACTBACKGROUND: Neuropathic pain has long been a very popular and productive field of clinical research. Neuropathic pain is difficult to cure radically because of its complicated etiology and uncertain pathogenesis. As pain worsens and persists, pain recovery techniques become more important, and medication alone is insufficient. No summary of bibliometric studies on neuropathic pain rehabilitation is yet available. The purpose of the present study is to analyze in a systematic manner the trends of neuropathic pain rehabilitation resear...
Source: Neural Plasticity - July 26, 2021 Category: Neurology Authors: Xuan Su Hao-Yu Hu Chang Xu Source Type: research

Astrocytes in the Ventromedial Hypothalamus Involve Chronic Stress-Induced Anxiety and Bone Loss in Mice
This study not only advances our understanding of glial cell function but also provides a potential intervention target for chronic stress-induced anxiety and bone loss therapy.PMID:34306063 | PMC:PMC8282369 | DOI:10.1155/2021/7806370 (Source: Neural Plasticity)
Source: Neural Plasticity - July 26, 2021 Category: Neurology Authors: Yunhui Liu Jie Shao Dashuang Gao Lu Zhang Fan Yang Source Type: research

Low Back Pain Assessment Based on Alpha Oscillation Changes in Spontaneous Electroencephalogram (EEG)
Neural Plast. 2021 Jul 1;2021:8537437. doi: 10.1155/2021/8537437. eCollection 2021.ABSTRACTObjectively and accurately assessing pain in clinical settings is challenging. Previous studies showed that alpha oscillations of electroencephalogram data are correlated with subjective perceived pain. Based on this finding, this study is aimed at assessing chronic low back pain based on alpha oscillations. Multichannel electroencephalogram data were recorded from 27 subjects with chronic low back pain under the simple conditions of closing eyes or opening eyes. Spectral analyses were conducted to extract the alpha band responses, a...
Source: Neural Plasticity - July 26, 2021 Category: Neurology Authors: Li Feng Hanlei Li Hongyan Cui Xiaobo Xie Shengpu Xu Yong Hu Source Type: research

Inhibitory Control Deficits in Children with Tic Disorders Revealed by Object-Hit-and-Avoid Task
CONCLUSIONS: In children with tics (without comorbid ADHD), acting upon both targets and distractors suggests reduced ability to suppress responses to potential triggers for action. This may be related to increased sensorimotor noise or abnormal sensory gating.PMID:34306065 | PMC:PMC8270726 | DOI:10.1155/2021/8825091 (Source: Neural Plasticity)
Source: Neural Plasticity - July 26, 2021 Category: Neurology Authors: Nicholas Cothros Alex Medina Davide Martino Sean P Dukelow Rachel L Hawe Adam Kirton Christos Ganos Elaheh Nosratmirshekarlou Tamara Pringsheim Source Type: research

Noise-Induced Hearing Loss: Updates on Molecular Targets and Potential Interventions
Neural Plast. 2021 Jul 6;2021:4784385. doi: 10.1155/2021/4784385. eCollection 2021.ABSTRACTNoise overexposure leads to hair cell loss, synaptic ribbon reduction, and auditory nerve deterioration, resulting in transient or permanent hearing loss depending on the exposure severity. Oxidative stress, inflammation, calcium overload, glutamate excitotoxicity, and energy metabolism disturbance are the main contributors to noise-induced hearing loss (NIHL) up to now. Gene variations are also identified as NIHL related. Glucocorticoid is the only approved medication for NIHL treatment. New pharmaceuticals targeting oxidative stres...
Source: Neural Plasticity - July 26, 2021 Category: Neurology Authors: Huanyu Mao Yan Chen Source Type: research

Autophagy: A Novel Horizon for Hair Cell Protection
Neural Plast. 2021 Jun 29;2021:5511010. doi: 10.1155/2021/5511010. eCollection 2021.ABSTRACTAs a general sensory disorder, hearing loss was a major concern worldwide. Autophagy is a common cellular reaction to stress that degrades cytoplasmic waste through the lysosome pathway. Autophagy not only plays major roles in maintaining intracellular homeostasis but is also involved in the development and pathogenesis of many diseases. In the auditory system, several studies revealed the link between autophagy and hearing protection. In this review, we aimed to establish the correlation between autophagy and hair cells (HCs) from ...
Source: Neural Plasticity - July 26, 2021 Category: Neurology Authors: Chang Liu Zhiwei Zheng Pengjun Wang Shuangba He Yingzi He Source Type: research

Global Research on Neuropathic Pain Rehabilitation over the Last 20 Years
Neural Plast. 2021 Jul 7;2021:5594512. doi: 10.1155/2021/5594512. eCollection 2021.ABSTRACTBACKGROUND: Neuropathic pain has long been a very popular and productive field of clinical research. Neuropathic pain is difficult to cure radically because of its complicated etiology and uncertain pathogenesis. As pain worsens and persists, pain recovery techniques become more important, and medication alone is insufficient. No summary of bibliometric studies on neuropathic pain rehabilitation is yet available. The purpose of the present study is to analyze in a systematic manner the trends of neuropathic pain rehabilitation resear...
Source: Neural Plasticity - July 26, 2021 Category: Neurology Authors: Xuan Su Hao-Yu Hu Chang Xu Source Type: research

Astrocytes in the Ventromedial Hypothalamus Involve Chronic Stress-Induced Anxiety and Bone Loss in Mice
This study not only advances our understanding of glial cell function but also provides a potential intervention target for chronic stress-induced anxiety and bone loss therapy.PMID:34306063 | PMC:PMC8282369 | DOI:10.1155/2021/7806370 (Source: Neural Plasticity)
Source: Neural Plasticity - July 26, 2021 Category: Neurology Authors: Yunhui Liu Jie Shao Dashuang Gao Lu Zhang Fan Yang Source Type: research

Low Back Pain Assessment Based on Alpha Oscillation Changes in Spontaneous Electroencephalogram (EEG)
Neural Plast. 2021 Jul 1;2021:8537437. doi: 10.1155/2021/8537437. eCollection 2021.ABSTRACTObjectively and accurately assessing pain in clinical settings is challenging. Previous studies showed that alpha oscillations of electroencephalogram data are correlated with subjective perceived pain. Based on this finding, this study is aimed at assessing chronic low back pain based on alpha oscillations. Multichannel electroencephalogram data were recorded from 27 subjects with chronic low back pain under the simple conditions of closing eyes or opening eyes. Spectral analyses were conducted to extract the alpha band responses, a...
Source: Neural Plasticity - July 26, 2021 Category: Neurology Authors: Li Feng Hanlei Li Hongyan Cui Xiaobo Xie Shengpu Xu Yong Hu Source Type: research

Inhibitory Control Deficits in Children with Tic Disorders Revealed by Object-Hit-and-Avoid Task
CONCLUSIONS: In children with tics (without comorbid ADHD), acting upon both targets and distractors suggests reduced ability to suppress responses to potential triggers for action. This may be related to increased sensorimotor noise or abnormal sensory gating.PMID:34306065 | PMC:PMC8270726 | DOI:10.1155/2021/8825091 (Source: Neural Plasticity)
Source: Neural Plasticity - July 26, 2021 Category: Neurology Authors: Nicholas Cothros Alex Medina Davide Martino Sean P Dukelow Rachel L Hawe Adam Kirton Christos Ganos Elaheh Nosratmirshekarlou Tamara Pringsheim Source Type: research

Noise-Induced Hearing Loss: Updates on Molecular Targets and Potential Interventions
Neural Plast. 2021 Jul 6;2021:4784385. doi: 10.1155/2021/4784385. eCollection 2021.ABSTRACTNoise overexposure leads to hair cell loss, synaptic ribbon reduction, and auditory nerve deterioration, resulting in transient or permanent hearing loss depending on the exposure severity. Oxidative stress, inflammation, calcium overload, glutamate excitotoxicity, and energy metabolism disturbance are the main contributors to noise-induced hearing loss (NIHL) up to now. Gene variations are also identified as NIHL related. Glucocorticoid is the only approved medication for NIHL treatment. New pharmaceuticals targeting oxidative stres...
Source: Neural Plasticity - July 26, 2021 Category: Neurology Authors: Huanyu Mao Yan Chen Source Type: research

Autophagy: A Novel Horizon for Hair Cell Protection
Neural Plast. 2021 Jun 29;2021:5511010. doi: 10.1155/2021/5511010. eCollection 2021.ABSTRACTAs a general sensory disorder, hearing loss was a major concern worldwide. Autophagy is a common cellular reaction to stress that degrades cytoplasmic waste through the lysosome pathway. Autophagy not only plays major roles in maintaining intracellular homeostasis but is also involved in the development and pathogenesis of many diseases. In the auditory system, several studies revealed the link between autophagy and hearing protection. In this review, we aimed to establish the correlation between autophagy and hair cells (HCs) from ...
Source: Neural Plasticity - July 26, 2021 Category: Neurology Authors: Chang Liu Zhiwei Zheng Pengjun Wang Shuangba He Yingzi He Source Type: research

Global Research on Neuropathic Pain Rehabilitation over the Last 20 Years
Neural Plast. 2021 Jul 7;2021:5594512. doi: 10.1155/2021/5594512. eCollection 2021.ABSTRACTBACKGROUND: Neuropathic pain has long been a very popular and productive field of clinical research. Neuropathic pain is difficult to cure radically because of its complicated etiology and uncertain pathogenesis. As pain worsens and persists, pain recovery techniques become more important, and medication alone is insufficient. No summary of bibliometric studies on neuropathic pain rehabilitation is yet available. The purpose of the present study is to analyze in a systematic manner the trends of neuropathic pain rehabilitation resear...
Source: Neural Plasticity - July 26, 2021 Category: Neurology Authors: Xuan Su Hao-Yu Hu Chang Xu Source Type: research

Astrocytes in the Ventromedial Hypothalamus Involve Chronic Stress-Induced Anxiety and Bone Loss in Mice
This study not only advances our understanding of glial cell function but also provides a potential intervention target for chronic stress-induced anxiety and bone loss therapy.PMID:34306063 | PMC:PMC8282369 | DOI:10.1155/2021/7806370 (Source: Neural Plasticity)
Source: Neural Plasticity - July 26, 2021 Category: Neurology Authors: Yunhui Liu Jie Shao Dashuang Gao Lu Zhang Fan Yang Source Type: research

Low Back Pain Assessment Based on Alpha Oscillation Changes in Spontaneous Electroencephalogram (EEG)
Neural Plast. 2021 Jul 1;2021:8537437. doi: 10.1155/2021/8537437. eCollection 2021.ABSTRACTObjectively and accurately assessing pain in clinical settings is challenging. Previous studies showed that alpha oscillations of electroencephalogram data are correlated with subjective perceived pain. Based on this finding, this study is aimed at assessing chronic low back pain based on alpha oscillations. Multichannel electroencephalogram data were recorded from 27 subjects with chronic low back pain under the simple conditions of closing eyes or opening eyes. Spectral analyses were conducted to extract the alpha band responses, a...
Source: Neural Plasticity - July 26, 2021 Category: Neurology Authors: Li Feng Hanlei Li Hongyan Cui Xiaobo Xie Shengpu Xu Yong Hu Source Type: research

Inhibitory Control Deficits in Children with Tic Disorders Revealed by Object-Hit-and-Avoid Task
CONCLUSIONS: In children with tics (without comorbid ADHD), acting upon both targets and distractors suggests reduced ability to suppress responses to potential triggers for action. This may be related to increased sensorimotor noise or abnormal sensory gating.PMID:34306065 | PMC:PMC8270726 | DOI:10.1155/2021/8825091 (Source: Neural Plasticity)
Source: Neural Plasticity - July 26, 2021 Category: Neurology Authors: Nicholas Cothros Alex Medina Davide Martino Sean P Dukelow Rachel L Hawe Adam Kirton Christos Ganos Elaheh Nosratmirshekarlou Tamara Pringsheim Source Type: research

Model-Based Analysis of Muscle Strength and EMG-Force Relation with respect to Different Patterns of Motor Unit Loss
This study presents a model-based sensitivity analysis of the strength of voluntary muscle contraction with respect to different patterns of motor unit loss. A motor unit pool model was implemented including simulation of a motor neuron pool, muscle force, and surface electromyogram (EMG) signals. Three different patterns of motor unit loss were simulated, including (1) motor unit loss restricted to the largest ones, (2) motor unit loss restricted to the smallest ones, and (3) motor unit loss without size restriction. The model outputs including muscle force amplitude, variability, and the resultant EMG-force relation were...
Source: Neural Plasticity - July 14, 2021 Category: Neurology Authors: Chengjun Huang Maoqi Chen Yingchun Zhang Sheng Li Ping Zhou Source Type: research

The Anticonvulsant Effect of Hydroethanolic Leaf Extract of < em > Calotropis procera < /em > (Ait) R. Br. (Apocynaceae)
This study is conducted to explore the anticonvulsant effect of a hydroethanolic leaf extract of Calotropis procera (CPE) in murine models. This effect was evaluated using picrotoxin-induced convulsions, strychnine-induced convulsions, and isoniazid- and pilocarpine-induced status epilepticus in mice of both sexes. The results showed that CPE (100-300 mg/kg) exhibited an anticonvulsant effect against strychnine-induced clonic seizures by significantly reducing the duration (p = 0.0068) and frequency (p = 0.0016) of convulsions. The extract (100-300 mg/kg) caused a profound dose-dependent delay in the onset of clonic convul...
Source: Neural Plasticity - July 14, 2021 Category: Neurology Authors: Ernest Obese Robert Peter Biney Isaac Tabiri Henneh Emmanuel Awintiig Adakudugu Daniel Anokwah Lovia Serwaa Agyemang Eric Woode Elvis Ofori Ameyaw Source Type: research

Transcranial Direct Current Stimulation (tDCS) over the Left Dorsal Lateral Prefrontal Cortex in Children with Autism Spectrum Disorder (ASD)
Neural Plast. 2021 Jun 19;2021:6627507. doi: 10.1155/2021/6627507. eCollection 2021.ABSTRACTRecently, transcranial direct current stimulation (tDCS) has been applied to relieve symptoms in individuals with autism spectrum disorder (ASD). In this prospective, parallel, single-blinded, randomized study, we investigate the modulation effect of three-week tDCS treatment at the left dorsal lateral prefrontal cortex (DLPFC) in children with ASD. 47 children with ASD were enrolled, and 40 (20 in each group) completed the study. The primary outcomes are Childhood Autism Rating Scale (CARS), Aberrant Behavior Checklist (ABC), and t...
Source: Neural Plasticity - July 14, 2021 Category: Neurology Authors: Jiujun Qiu Xuejun Kong Jihan Li Jie Yang Yiting Huang Minshi Huang Binbin Sun Jiayi Su Helen Chen Guobin Wan Jian Kong Source Type: research

Restoration of Deafferentation Reduces Tinnitus, Anxiety, and Depression: A Retrospective Study on Cochlear Implant Patients
This study was aimed at investigating the effect of cochlear implants (CIs) on tinnitus distress and psychological comorbidities in patients with profound BD. This multicenter retrospective study reviewed 51 patients with severe postlingual BD who underwent cochlear implantation; 49 patients underwent unilateral cochlear implantation, and 2 patients underwent bilateral cochlear implantation. The patients were asked to complete all the questionnaires, including the tinnitus handicap inventory (THI), the visual analog scale (VAS) score, the Hospital Anxiety and Depression Scale Questionnaire (HADS), the Categories of Auditor...
Source: Neural Plasticity - July 14, 2021 Category: Neurology Authors: Juanmei Yang Jing Song Xiang Zhao Carol Pang Ning Cong Zhao Han Source Type: research

Model-Based Analysis of Muscle Strength and EMG-Force Relation with respect to Different Patterns of Motor Unit Loss
This study presents a model-based sensitivity analysis of the strength of voluntary muscle contraction with respect to different patterns of motor unit loss. A motor unit pool model was implemented including simulation of a motor neuron pool, muscle force, and surface electromyogram (EMG) signals. Three different patterns of motor unit loss were simulated, including (1) motor unit loss restricted to the largest ones, (2) motor unit loss restricted to the smallest ones, and (3) motor unit loss without size restriction. The model outputs including muscle force amplitude, variability, and the resultant EMG-force relation were...
Source: Neural Plasticity - July 14, 2021 Category: Neurology Authors: Chengjun Huang Maoqi Chen Yingchun Zhang Sheng Li Ping Zhou Source Type: research

The Anticonvulsant Effect of Hydroethanolic Leaf Extract of < em > Calotropis procera < /em > (Ait) R. Br. (Apocynaceae)
This study is conducted to explore the anticonvulsant effect of a hydroethanolic leaf extract of Calotropis procera (CPE) in murine models. This effect was evaluated using picrotoxin-induced convulsions, strychnine-induced convulsions, and isoniazid- and pilocarpine-induced status epilepticus in mice of both sexes. The results showed that CPE (100-300 mg/kg) exhibited an anticonvulsant effect against strychnine-induced clonic seizures by significantly reducing the duration (p = 0.0068) and frequency (p = 0.0016) of convulsions. The extract (100-300 mg/kg) caused a profound dose-dependent delay in the onset of clonic convul...
Source: Neural Plasticity - July 14, 2021 Category: Neurology Authors: Ernest Obese Robert Peter Biney Isaac Tabiri Henneh Emmanuel Awintiig Adakudugu Daniel Anokwah Lovia Serwaa Agyemang Eric Woode Elvis Ofori Ameyaw Source Type: research

Transcranial Direct Current Stimulation (tDCS) over the Left Dorsal Lateral Prefrontal Cortex in Children with Autism Spectrum Disorder (ASD)
Neural Plast. 2021 Jun 19;2021:6627507. doi: 10.1155/2021/6627507. eCollection 2021.ABSTRACTRecently, transcranial direct current stimulation (tDCS) has been applied to relieve symptoms in individuals with autism spectrum disorder (ASD). In this prospective, parallel, single-blinded, randomized study, we investigate the modulation effect of three-week tDCS treatment at the left dorsal lateral prefrontal cortex (DLPFC) in children with ASD. 47 children with ASD were enrolled, and 40 (20 in each group) completed the study. The primary outcomes are Childhood Autism Rating Scale (CARS), Aberrant Behavior Checklist (ABC), and t...
Source: Neural Plasticity - July 14, 2021 Category: Neurology Authors: Jiujun Qiu Xuejun Kong Jihan Li Jie Yang Yiting Huang Minshi Huang Binbin Sun Jiayi Su Helen Chen Guobin Wan Jian Kong Source Type: research

Restoration of Deafferentation Reduces Tinnitus, Anxiety, and Depression: A Retrospective Study on Cochlear Implant Patients
This study was aimed at investigating the effect of cochlear implants (CIs) on tinnitus distress and psychological comorbidities in patients with profound BD. This multicenter retrospective study reviewed 51 patients with severe postlingual BD who underwent cochlear implantation; 49 patients underwent unilateral cochlear implantation, and 2 patients underwent bilateral cochlear implantation. The patients were asked to complete all the questionnaires, including the tinnitus handicap inventory (THI), the visual analog scale (VAS) score, the Hospital Anxiety and Depression Scale Questionnaire (HADS), the Categories of Auditor...
Source: Neural Plasticity - July 14, 2021 Category: Neurology Authors: Juanmei Yang Jing Song Xiang Zhao Carol Pang Ning Cong Zhao Han Source Type: research

Model-Based Analysis of Muscle Strength and EMG-Force Relation with respect to Different Patterns of Motor Unit Loss
This study presents a model-based sensitivity analysis of the strength of voluntary muscle contraction with respect to different patterns of motor unit loss. A motor unit pool model was implemented including simulation of a motor neuron pool, muscle force, and surface electromyogram (EMG) signals. Three different patterns of motor unit loss were simulated, including (1) motor unit loss restricted to the largest ones, (2) motor unit loss restricted to the smallest ones, and (3) motor unit loss without size restriction. The model outputs including muscle force amplitude, variability, and the resultant EMG-force relation were...
Source: Neural Plasticity - July 14, 2021 Category: Neurology Authors: Chengjun Huang Maoqi Chen Yingchun Zhang Sheng Li Ping Zhou Source Type: research

The Anticonvulsant Effect of Hydroethanolic Leaf Extract of < em > Calotropis procera < /em > (Ait) R. Br. (Apocynaceae)
This study is conducted to explore the anticonvulsant effect of a hydroethanolic leaf extract of Calotropis procera (CPE) in murine models. This effect was evaluated using picrotoxin-induced convulsions, strychnine-induced convulsions, and isoniazid- and pilocarpine-induced status epilepticus in mice of both sexes. The results showed that CPE (100-300 mg/kg) exhibited an anticonvulsant effect against strychnine-induced clonic seizures by significantly reducing the duration (p = 0.0068) and frequency (p = 0.0016) of convulsions. The extract (100-300 mg/kg) caused a profound dose-dependent delay in the onset of clonic convul...
Source: Neural Plasticity - July 14, 2021 Category: Neurology Authors: Ernest Obese Robert Peter Biney Isaac Tabiri Henneh Emmanuel Awintiig Adakudugu Daniel Anokwah Lovia Serwaa Agyemang Eric Woode Elvis Ofori Ameyaw Source Type: research

Transcranial Direct Current Stimulation (tDCS) over the Left Dorsal Lateral Prefrontal Cortex in Children with Autism Spectrum Disorder (ASD)
Neural Plast. 2021 Jun 19;2021:6627507. doi: 10.1155/2021/6627507. eCollection 2021.ABSTRACTRecently, transcranial direct current stimulation (tDCS) has been applied to relieve symptoms in individuals with autism spectrum disorder (ASD). In this prospective, parallel, single-blinded, randomized study, we investigate the modulation effect of three-week tDCS treatment at the left dorsal lateral prefrontal cortex (DLPFC) in children with ASD. 47 children with ASD were enrolled, and 40 (20 in each group) completed the study. The primary outcomes are Childhood Autism Rating Scale (CARS), Aberrant Behavior Checklist (ABC), and t...
Source: Neural Plasticity - July 14, 2021 Category: Neurology Authors: Jiujun Qiu Xuejun Kong Jihan Li Jie Yang Yiting Huang Minshi Huang Binbin Sun Jiayi Su Helen Chen Guobin Wan Jian Kong Source Type: research

Restoration of Deafferentation Reduces Tinnitus, Anxiety, and Depression: A Retrospective Study on Cochlear Implant Patients
This study was aimed at investigating the effect of cochlear implants (CIs) on tinnitus distress and psychological comorbidities in patients with profound BD. This multicenter retrospective study reviewed 51 patients with severe postlingual BD who underwent cochlear implantation; 49 patients underwent unilateral cochlear implantation, and 2 patients underwent bilateral cochlear implantation. The patients were asked to complete all the questionnaires, including the tinnitus handicap inventory (THI), the visual analog scale (VAS) score, the Hospital Anxiety and Depression Scale Questionnaire (HADS), the Categories of Auditor...
Source: Neural Plasticity - July 14, 2021 Category: Neurology Authors: Juanmei Yang Jing Song Xiang Zhao Carol Pang Ning Cong Zhao Han Source Type: research

Model-Based Analysis of Muscle Strength and EMG-Force Relation with respect to Different Patterns of Motor Unit Loss
This study presents a model-based sensitivity analysis of the strength of voluntary muscle contraction with respect to different patterns of motor unit loss. A motor unit pool model was implemented including simulation of a motor neuron pool, muscle force, and surface electromyogram (EMG) signals. Three different patterns of motor unit loss were simulated, including (1) motor unit loss restricted to the largest ones, (2) motor unit loss restricted to the smallest ones, and (3) motor unit loss without size restriction. The model outputs including muscle force amplitude, variability, and the resultant EMG-force relation were...
Source: Neural Plasticity - July 14, 2021 Category: Neurology Authors: Chengjun Huang Maoqi Chen Yingchun Zhang Sheng Li Ping Zhou Source Type: research

The Anticonvulsant Effect of Hydroethanolic Leaf Extract of < em > Calotropis procera < /em > (Ait) R. Br. (Apocynaceae)
This study is conducted to explore the anticonvulsant effect of a hydroethanolic leaf extract of Calotropis procera (CPE) in murine models. This effect was evaluated using picrotoxin-induced convulsions, strychnine-induced convulsions, and isoniazid- and pilocarpine-induced status epilepticus in mice of both sexes. The results showed that CPE (100-300 mg/kg) exhibited an anticonvulsant effect against strychnine-induced clonic seizures by significantly reducing the duration (p = 0.0068) and frequency (p = 0.0016) of convulsions. The extract (100-300 mg/kg) caused a profound dose-dependent delay in the onset of clonic convul...
Source: Neural Plasticity - July 14, 2021 Category: Neurology Authors: Ernest Obese Robert Peter Biney Isaac Tabiri Henneh Emmanuel Awintiig Adakudugu Daniel Anokwah Lovia Serwaa Agyemang Eric Woode Elvis Ofori Ameyaw Source Type: research

Transcranial Direct Current Stimulation (tDCS) over the Left Dorsal Lateral Prefrontal Cortex in Children with Autism Spectrum Disorder (ASD)
Neural Plast. 2021 Jun 19;2021:6627507. doi: 10.1155/2021/6627507. eCollection 2021.ABSTRACTRecently, transcranial direct current stimulation (tDCS) has been applied to relieve symptoms in individuals with autism spectrum disorder (ASD). In this prospective, parallel, single-blinded, randomized study, we investigate the modulation effect of three-week tDCS treatment at the left dorsal lateral prefrontal cortex (DLPFC) in children with ASD. 47 children with ASD were enrolled, and 40 (20 in each group) completed the study. The primary outcomes are Childhood Autism Rating Scale (CARS), Aberrant Behavior Checklist (ABC), and t...
Source: Neural Plasticity - July 14, 2021 Category: Neurology Authors: Jiujun Qiu Xuejun Kong Jihan Li Jie Yang Yiting Huang Minshi Huang Binbin Sun Jiayi Su Helen Chen Guobin Wan Jian Kong Source Type: research

Restoration of Deafferentation Reduces Tinnitus, Anxiety, and Depression: A Retrospective Study on Cochlear Implant Patients
This study was aimed at investigating the effect of cochlear implants (CIs) on tinnitus distress and psychological comorbidities in patients with profound BD. This multicenter retrospective study reviewed 51 patients with severe postlingual BD who underwent cochlear implantation; 49 patients underwent unilateral cochlear implantation, and 2 patients underwent bilateral cochlear implantation. The patients were asked to complete all the questionnaires, including the tinnitus handicap inventory (THI), the visual analog scale (VAS) score, the Hospital Anxiety and Depression Scale Questionnaire (HADS), the Categories of Auditor...
Source: Neural Plasticity - July 14, 2021 Category: Neurology Authors: Juanmei Yang Jing Song Xiang Zhao Carol Pang Ning Cong Zhao Han Source Type: research

Model-Based Analysis of Muscle Strength and EMG-Force Relation with respect to Different Patterns of Motor Unit Loss
This study presents a model-based sensitivity analysis of the strength of voluntary muscle contraction with respect to different patterns of motor unit loss. A motor unit pool model was implemented including simulation of a motor neuron pool, muscle force, and surface electromyogram (EMG) signals. Three different patterns of motor unit loss were simulated, including (1) motor unit loss restricted to the largest ones, (2) motor unit loss restricted to the smallest ones, and (3) motor unit loss without size restriction. The model outputs including muscle force amplitude, variability, and the resultant EMG-force relation were...
Source: Neural Plasticity - July 14, 2021 Category: Neurology Authors: Chengjun Huang Maoqi Chen Yingchun Zhang Sheng Li Ping Zhou Source Type: research

The Anticonvulsant Effect of Hydroethanolic Leaf Extract of < em > Calotropis procera < /em > (Ait) R. Br. (Apocynaceae)
This study is conducted to explore the anticonvulsant effect of a hydroethanolic leaf extract of Calotropis procera (CPE) in murine models. This effect was evaluated using picrotoxin-induced convulsions, strychnine-induced convulsions, and isoniazid- and pilocarpine-induced status epilepticus in mice of both sexes. The results showed that CPE (100-300 mg/kg) exhibited an anticonvulsant effect against strychnine-induced clonic seizures by significantly reducing the duration (p = 0.0068) and frequency (p = 0.0016) of convulsions. The extract (100-300 mg/kg) caused a profound dose-dependent delay in the onset of clonic convul...
Source: Neural Plasticity - July 14, 2021 Category: Neurology Authors: Ernest Obese Robert Peter Biney Isaac Tabiri Henneh Emmanuel Awintiig Adakudugu Daniel Anokwah Lovia Serwaa Agyemang Eric Woode Elvis Ofori Ameyaw Source Type: research

Transcranial Direct Current Stimulation (tDCS) over the Left Dorsal Lateral Prefrontal Cortex in Children with Autism Spectrum Disorder (ASD)
Neural Plast. 2021 Jun 19;2021:6627507. doi: 10.1155/2021/6627507. eCollection 2021.ABSTRACTRecently, transcranial direct current stimulation (tDCS) has been applied to relieve symptoms in individuals with autism spectrum disorder (ASD). In this prospective, parallel, single-blinded, randomized study, we investigate the modulation effect of three-week tDCS treatment at the left dorsal lateral prefrontal cortex (DLPFC) in children with ASD. 47 children with ASD were enrolled, and 40 (20 in each group) completed the study. The primary outcomes are Childhood Autism Rating Scale (CARS), Aberrant Behavior Checklist (ABC), and t...
Source: Neural Plasticity - July 14, 2021 Category: Neurology Authors: Jiujun Qiu Xuejun Kong Jihan Li Jie Yang Yiting Huang Minshi Huang Binbin Sun Jiayi Su Helen Chen Guobin Wan Jian Kong Source Type: research

Restoration of Deafferentation Reduces Tinnitus, Anxiety, and Depression: A Retrospective Study on Cochlear Implant Patients
This study was aimed at investigating the effect of cochlear implants (CIs) on tinnitus distress and psychological comorbidities in patients with profound BD. This multicenter retrospective study reviewed 51 patients with severe postlingual BD who underwent cochlear implantation; 49 patients underwent unilateral cochlear implantation, and 2 patients underwent bilateral cochlear implantation. The patients were asked to complete all the questionnaires, including the tinnitus handicap inventory (THI), the visual analog scale (VAS) score, the Hospital Anxiety and Depression Scale Questionnaire (HADS), the Categories of Auditor...
Source: Neural Plasticity - July 14, 2021 Category: Neurology Authors: Juanmei Yang Jing Song Xiang Zhao Carol Pang Ning Cong Zhao Han Source Type: research

Model-Based Analysis of Muscle Strength and EMG-Force Relation with respect to Different Patterns of Motor Unit Loss
This study presents a model-based sensitivity analysis of the strength of voluntary muscle contraction with respect to different patterns of motor unit loss. A motor unit pool model was implemented including simulation of a motor neuron pool, muscle force, and surface electromyogram (EMG) signals. Three different patterns of motor unit loss were simulated, including (1) motor unit loss restricted to the largest ones, (2) motor unit loss restricted to the smallest ones, and (3) motor unit loss without size restriction. The model outputs including muscle force amplitude, variability, and the resultant EMG-force relation were...
Source: Neural Plasticity - July 14, 2021 Category: Neurology Authors: Chengjun Huang Maoqi Chen Yingchun Zhang Sheng Li Ping Zhou Source Type: research

The Anticonvulsant Effect of Hydroethanolic Leaf Extract of < em > Calotropis procera < /em > (Ait) R. Br. (Apocynaceae)
This study is conducted to explore the anticonvulsant effect of a hydroethanolic leaf extract of Calotropis procera (CPE) in murine models. This effect was evaluated using picrotoxin-induced convulsions, strychnine-induced convulsions, and isoniazid- and pilocarpine-induced status epilepticus in mice of both sexes. The results showed that CPE (100-300 mg/kg) exhibited an anticonvulsant effect against strychnine-induced clonic seizures by significantly reducing the duration (p = 0.0068) and frequency (p = 0.0016) of convulsions. The extract (100-300 mg/kg) caused a profound dose-dependent delay in the onset of clonic convul...
Source: Neural Plasticity - July 14, 2021 Category: Neurology Authors: Ernest Obese Robert Peter Biney Isaac Tabiri Henneh Emmanuel Awintiig Adakudugu Daniel Anokwah Lovia Serwaa Agyemang Eric Woode Elvis Ofori Ameyaw Source Type: research

Transcranial Direct Current Stimulation (tDCS) over the Left Dorsal Lateral Prefrontal Cortex in Children with Autism Spectrum Disorder (ASD)
Neural Plast. 2021 Jun 19;2021:6627507. doi: 10.1155/2021/6627507. eCollection 2021.ABSTRACTRecently, transcranial direct current stimulation (tDCS) has been applied to relieve symptoms in individuals with autism spectrum disorder (ASD). In this prospective, parallel, single-blinded, randomized study, we investigate the modulation effect of three-week tDCS treatment at the left dorsal lateral prefrontal cortex (DLPFC) in children with ASD. 47 children with ASD were enrolled, and 40 (20 in each group) completed the study. The primary outcomes are Childhood Autism Rating Scale (CARS), Aberrant Behavior Checklist (ABC), and t...
Source: Neural Plasticity - July 14, 2021 Category: Neurology Authors: Jiujun Qiu Xuejun Kong Jihan Li Jie Yang Yiting Huang Minshi Huang Binbin Sun Jiayi Su Helen Chen Guobin Wan Jian Kong Source Type: research

Restoration of Deafferentation Reduces Tinnitus, Anxiety, and Depression: A Retrospective Study on Cochlear Implant Patients
This study was aimed at investigating the effect of cochlear implants (CIs) on tinnitus distress and psychological comorbidities in patients with profound BD. This multicenter retrospective study reviewed 51 patients with severe postlingual BD who underwent cochlear implantation; 49 patients underwent unilateral cochlear implantation, and 2 patients underwent bilateral cochlear implantation. The patients were asked to complete all the questionnaires, including the tinnitus handicap inventory (THI), the visual analog scale (VAS) score, the Hospital Anxiety and Depression Scale Questionnaire (HADS), the Categories of Auditor...
Source: Neural Plasticity - July 14, 2021 Category: Neurology Authors: Juanmei Yang Jing Song Xiang Zhao Carol Pang Ning Cong Zhao Han Source Type: research

Model-Based Analysis of Muscle Strength and EMG-Force Relation with respect to Different Patterns of Motor Unit Loss
This study presents a model-based sensitivity analysis of the strength of voluntary muscle contraction with respect to different patterns of motor unit loss. A motor unit pool model was implemented including simulation of a motor neuron pool, muscle force, and surface electromyogram (EMG) signals. Three different patterns of motor unit loss were simulated, including (1) motor unit loss restricted to the largest ones, (2) motor unit loss restricted to the smallest ones, and (3) motor unit loss without size restriction. The model outputs including muscle force amplitude, variability, and the resultant EMG-force relation were...
Source: Neural Plasticity - July 14, 2021 Category: Neurology Authors: Chengjun Huang Maoqi Chen Yingchun Zhang Sheng Li Ping Zhou Source Type: research

The Anticonvulsant Effect of Hydroethanolic Leaf Extract of < em > Calotropis procera < /em > (Ait) R. Br. (Apocynaceae)
This study is conducted to explore the anticonvulsant effect of a hydroethanolic leaf extract of Calotropis procera (CPE) in murine models. This effect was evaluated using picrotoxin-induced convulsions, strychnine-induced convulsions, and isoniazid- and pilocarpine-induced status epilepticus in mice of both sexes. The results showed that CPE (100-300 mg/kg) exhibited an anticonvulsant effect against strychnine-induced clonic seizures by significantly reducing the duration (p = 0.0068) and frequency (p = 0.0016) of convulsions. The extract (100-300 mg/kg) caused a profound dose-dependent delay in the onset of clonic convul...
Source: Neural Plasticity - July 14, 2021 Category: Neurology Authors: Ernest Obese Robert Peter Biney Isaac Tabiri Henneh Emmanuel Awintiig Adakudugu Daniel Anokwah Lovia Serwaa Agyemang Eric Woode Elvis Ofori Ameyaw Source Type: research