Lycopene-Loaded Microemulsion Regulates Neurogenesis in Rats with A < em > β < /em > -Induced Alzheimer's Disease Rats Based on the Wnt/ < em > β < /em > -catenin Pathway
CONCLUSION: LME attenuates cognitive impairment in Aβ-induced AD rats by promoting neurogenesis in the hippocampus and SVZ region through upregulating the Wnt/β-catenin pathway.PMID:34545285 | PMC:PMC8448994 | DOI:10.1155/2021/5519330 (Source: Neural Plasticity)
Source: Neural Plasticity - September 21, 2021 Category: Neurology Authors: Wen-Jing Ning Ren-Jun Lv Ning Xu Xun-Yao Hou Chao Shen Yun-Liang Guo Zhong-Yu Fan Na Cao Xue-Ping Liu Source Type: research

Lycopene-Loaded Microemulsion Regulates Neurogenesis in Rats with A < em > β < /em > -Induced Alzheimer's Disease Rats Based on the Wnt/ < em > β < /em > -catenin Pathway
CONCLUSION: LME attenuates cognitive impairment in Aβ-induced AD rats by promoting neurogenesis in the hippocampus and SVZ region through upregulating the Wnt/β-catenin pathway.PMID:34545285 | PMC:PMC8448994 | DOI:10.1155/2021/5519330 (Source: Neural Plasticity)
Source: Neural Plasticity - September 21, 2021 Category: Neurology Authors: Wen-Jing Ning Ren-Jun Lv Ning Xu Xun-Yao Hou Chao Shen Yun-Liang Guo Zhong-Yu Fan Na Cao Xue-Ping Liu Source Type: research

Lycopene-Loaded Microemulsion Regulates Neurogenesis in Rats with A < em > β < /em > -Induced Alzheimer's Disease Rats Based on the Wnt/ < em > β < /em > -catenin Pathway
CONCLUSION: LME attenuates cognitive impairment in Aβ-induced AD rats by promoting neurogenesis in the hippocampus and SVZ region through upregulating the Wnt/β-catenin pathway.PMID:34545285 | PMC:PMC8448994 | DOI:10.1155/2021/5519330 (Source: Neural Plasticity)
Source: Neural Plasticity - September 21, 2021 Category: Neurology Authors: Wen-Jing Ning Ren-Jun Lv Ning Xu Xun-Yao Hou Chao Shen Yun-Liang Guo Zhong-Yu Fan Na Cao Xue-Ping Liu Source Type: research

Lycopene-Loaded Microemulsion Regulates Neurogenesis in Rats with A < em > β < /em > -Induced Alzheimer's Disease Rats Based on the Wnt/ < em > β < /em > -catenin Pathway
CONCLUSION: LME attenuates cognitive impairment in Aβ-induced AD rats by promoting neurogenesis in the hippocampus and SVZ region through upregulating the Wnt/β-catenin pathway.PMID:34545285 | PMC:PMC8448994 | DOI:10.1155/2021/5519330 (Source: Neural Plasticity)
Source: Neural Plasticity - September 21, 2021 Category: Neurology Authors: Wen-Jing Ning Ren-Jun Lv Ning Xu Xun-Yao Hou Chao Shen Yun-Liang Guo Zhong-Yu Fan Na Cao Xue-Ping Liu Source Type: research

Reproduction-Associated Hormones and Adult Hippocampal Neurogenesis
Neural Plast. 2021 Sep 10;2021:3651735. doi: 10.1155/2021/3651735. eCollection 2021.ABSTRACTThe levels of reproduction-associated hormones in females, such as estrogen, progesterone, prolactin, and oxytocin, change dramatically during pregnancy and postpartum. Reproduction-associated hormones can affect adult hippocampal neurogenesis (AHN), thereby regulating mothers' behavior after delivery. In this review, we first briefly introduce the overall functional significance of AHN and the methods commonly used to explore this front. Then, we attempt to reconcile the changes of reproduction-associated hormones during pregnancy....
Source: Neural Plasticity - September 20, 2021 Category: Neurology Authors: Lily Wan Rou-Jie Huang Zhao-Hui Luo Jiao-E Gong Aihua Pan Jim Manavis Xiao-Xin Yan Bo Xiao Source Type: research

Altered Functional Connectivity Strength at Rest in Medication-Free Obsessive-Compulsive Disorder
CONCLUSION: Altered degree values within and outside the cortical-striatal-thalamic-cortical (CSTC) circuit may cocontribute to the pathophysiology of OCD. Increased degree values of the left thalamus can be used as a future marker for OCD understanding-classification.PMID:34539777 | PMC:PMC8443365 | DOI:10.1155/2021/3741104 (Source: Neural Plasticity)
Source: Neural Plasticity - September 20, 2021 Category: Neurology Authors: Dan Lv Yangpan Ou Yuhua Wang Jidong Ma Chuang Zhan Ru Yang Yunhui Chen Tinghuizi Shang Cuicui Jia Lei Sun Guangfeng Zhang Zhenghai Sun Jinyang Li Xiaoping Wang Wenbin Guo Ping Li Source Type: research

Microglial Activation of GLP-1R Signaling in Neuropathic Pain Promotes Gene Expression Adaption Involved in Inflammatory Responses
CONCLUSIONS: Our results further confirmed that the GLP-1R pathway is involved in alleviating pain hypersensitivity mediated by spinal microglia activation, and inflammatory responses were the most correlated pathway associated with PWL changes in response to exenatide treatment. We found that the identification of gene regulation in response to GLP-1R activation is an effective strategy for identifying new therapeutic targets for neuropathic pain. Investigation for the activation of spinal microglial GLP-1R which might ameliorate inflammatory responses through gene expression and structural changes is providing a potentia...
Source: Neural Plasticity - September 13, 2021 Category: Neurology Authors: Le Ma Peijun Ju Wei Wang Jinbao Wei Weidi Wang Mengjing Zhao Khalil Ali Ahmad Yongxiang Wang Jinghong Chen Source Type: research

Increased Homotopic Connectivity in the Prefrontal Cortex Modulated by Olanzapine Predicts Therapeutic Efficacy in Patients with Schizophrenia
CONCLUSIONS: This study demonstrated that olanzapine treatment may normalize decreased homotopic connectivity in the superior/middle MPFC in schizophrenic patients. The VMHC in the superior/middle MPFC may predict individual response for antipsychotic therapy. The findings of this study conduce to the comprehension of the therapy effects of antipsychotic medications on homotopic connectivity in schizophrenia.PMID:34512748 | PMC:PMC8429031 | DOI:10.1155/2021/9954547 (Source: Neural Plasticity)
Source: Neural Plasticity - September 13, 2021 Category: Neurology Authors: Xiaoxiao Shan Rongyuan Liao Yangpan Ou Yudan Ding Feng Liu Jindong Chen Jingping Zhao Yiqun He Wenbin Guo Source Type: research

Microglial Activation of GLP-1R Signaling in Neuropathic Pain Promotes Gene Expression Adaption Involved in Inflammatory Responses
CONCLUSIONS: Our results further confirmed that the GLP-1R pathway is involved in alleviating pain hypersensitivity mediated by spinal microglia activation, and inflammatory responses were the most correlated pathway associated with PWL changes in response to exenatide treatment. We found that the identification of gene regulation in response to GLP-1R activation is an effective strategy for identifying new therapeutic targets for neuropathic pain. Investigation for the activation of spinal microglial GLP-1R which might ameliorate inflammatory responses through gene expression and structural changes is providing a potentia...
Source: Neural Plasticity - September 13, 2021 Category: Neurology Authors: Le Ma Peijun Ju Wei Wang Jinbao Wei Weidi Wang Mengjing Zhao Khalil Ali Ahmad Yongxiang Wang Jinghong Chen Source Type: research

Increased Homotopic Connectivity in the Prefrontal Cortex Modulated by Olanzapine Predicts Therapeutic Efficacy in Patients with Schizophrenia
CONCLUSIONS: This study demonstrated that olanzapine treatment may normalize decreased homotopic connectivity in the superior/middle MPFC in schizophrenic patients. The VMHC in the superior/middle MPFC may predict individual response for antipsychotic therapy. The findings of this study conduce to the comprehension of the therapy effects of antipsychotic medications on homotopic connectivity in schizophrenia.PMID:34512748 | PMC:PMC8429031 | DOI:10.1155/2021/9954547 (Source: Neural Plasticity)
Source: Neural Plasticity - September 13, 2021 Category: Neurology Authors: Xiaoxiao Shan Rongyuan Liao Yangpan Ou Yudan Ding Feng Liu Jindong Chen Jingping Zhao Yiqun He Wenbin Guo Source Type: research

Microglial Activation of GLP-1R Signaling in Neuropathic Pain Promotes Gene Expression Adaption Involved in Inflammatory Responses
CONCLUSIONS: Our results further confirmed that the GLP-1R pathway is involved in alleviating pain hypersensitivity mediated by spinal microglia activation, and inflammatory responses were the most correlated pathway associated with PWL changes in response to exenatide treatment. We found that the identification of gene regulation in response to GLP-1R activation is an effective strategy for identifying new therapeutic targets for neuropathic pain. Investigation for the activation of spinal microglial GLP-1R which might ameliorate inflammatory responses through gene expression and structural changes is providing a potentia...
Source: Neural Plasticity - September 13, 2021 Category: Neurology Authors: Le Ma Peijun Ju Wei Wang Jinbao Wei Weidi Wang Mengjing Zhao Khalil Ali Ahmad Yongxiang Wang Jinghong Chen Source Type: research

Increased Homotopic Connectivity in the Prefrontal Cortex Modulated by Olanzapine Predicts Therapeutic Efficacy in Patients with Schizophrenia
CONCLUSIONS: This study demonstrated that olanzapine treatment may normalize decreased homotopic connectivity in the superior/middle MPFC in schizophrenic patients. The VMHC in the superior/middle MPFC may predict individual response for antipsychotic therapy. The findings of this study conduce to the comprehension of the therapy effects of antipsychotic medications on homotopic connectivity in schizophrenia.PMID:34512748 | PMC:PMC8429031 | DOI:10.1155/2021/9954547 (Source: Neural Plasticity)
Source: Neural Plasticity - September 13, 2021 Category: Neurology Authors: Xiaoxiao Shan Rongyuan Liao Yangpan Ou Yudan Ding Feng Liu Jindong Chen Jingping Zhao Yiqun He Wenbin Guo Source Type: research

Microglial Activation of GLP-1R Signaling in Neuropathic Pain Promotes Gene Expression Adaption Involved in Inflammatory Responses
CONCLUSIONS: Our results further confirmed that the GLP-1R pathway is involved in alleviating pain hypersensitivity mediated by spinal microglia activation, and inflammatory responses were the most correlated pathway associated with PWL changes in response to exenatide treatment. We found that the identification of gene regulation in response to GLP-1R activation is an effective strategy for identifying new therapeutic targets for neuropathic pain. Investigation for the activation of spinal microglial GLP-1R which might ameliorate inflammatory responses through gene expression and structural changes is providing a potentia...
Source: Neural Plasticity - September 13, 2021 Category: Neurology Authors: Le Ma Peijun Ju Wei Wang Jinbao Wei Weidi Wang Mengjing Zhao Khalil Ali Ahmad Yongxiang Wang Jinghong Chen Source Type: research

Increased Homotopic Connectivity in the Prefrontal Cortex Modulated by Olanzapine Predicts Therapeutic Efficacy in Patients with Schizophrenia
CONCLUSIONS: This study demonstrated that olanzapine treatment may normalize decreased homotopic connectivity in the superior/middle MPFC in schizophrenic patients. The VMHC in the superior/middle MPFC may predict individual response for antipsychotic therapy. The findings of this study conduce to the comprehension of the therapy effects of antipsychotic medications on homotopic connectivity in schizophrenia.PMID:34512748 | PMC:PMC8429031 | DOI:10.1155/2021/9954547 (Source: Neural Plasticity)
Source: Neural Plasticity - September 13, 2021 Category: Neurology Authors: Xiaoxiao Shan Rongyuan Liao Yangpan Ou Yudan Ding Feng Liu Jindong Chen Jingping Zhao Yiqun He Wenbin Guo Source Type: research

Microglial Activation of GLP-1R Signaling in Neuropathic Pain Promotes Gene Expression Adaption Involved in Inflammatory Responses
CONCLUSIONS: Our results further confirmed that the GLP-1R pathway is involved in alleviating pain hypersensitivity mediated by spinal microglia activation, and inflammatory responses were the most correlated pathway associated with PWL changes in response to exenatide treatment. We found that the identification of gene regulation in response to GLP-1R activation is an effective strategy for identifying new therapeutic targets for neuropathic pain. Investigation for the activation of spinal microglial GLP-1R which might ameliorate inflammatory responses through gene expression and structural changes is providing a potentia...
Source: Neural Plasticity - September 13, 2021 Category: Neurology Authors: Le Ma Peijun Ju Wei Wang Jinbao Wei Weidi Wang Mengjing Zhao Khalil Ali Ahmad Yongxiang Wang Jinghong Chen Source Type: research

Increased Homotopic Connectivity in the Prefrontal Cortex Modulated by Olanzapine Predicts Therapeutic Efficacy in Patients with Schizophrenia
CONCLUSIONS: This study demonstrated that olanzapine treatment may normalize decreased homotopic connectivity in the superior/middle MPFC in schizophrenic patients. The VMHC in the superior/middle MPFC may predict individual response for antipsychotic therapy. The findings of this study conduce to the comprehension of the therapy effects of antipsychotic medications on homotopic connectivity in schizophrenia.PMID:34512748 | PMC:PMC8429031 | DOI:10.1155/2021/9954547 (Source: Neural Plasticity)
Source: Neural Plasticity - September 13, 2021 Category: Neurology Authors: Xiaoxiao Shan Rongyuan Liao Yangpan Ou Yudan Ding Feng Liu Jindong Chen Jingping Zhao Yiqun He Wenbin Guo Source Type: research

Microglial Activation of GLP-1R Signaling in Neuropathic Pain Promotes Gene Expression Adaption Involved in Inflammatory Responses
CONCLUSIONS: Our results further confirmed that the GLP-1R pathway is involved in alleviating pain hypersensitivity mediated by spinal microglia activation, and inflammatory responses were the most correlated pathway associated with PWL changes in response to exenatide treatment. We found that the identification of gene regulation in response to GLP-1R activation is an effective strategy for identifying new therapeutic targets for neuropathic pain. Investigation for the activation of spinal microglial GLP-1R which might ameliorate inflammatory responses through gene expression and structural changes is providing a potentia...
Source: Neural Plasticity - September 13, 2021 Category: Neurology Authors: Le Ma Peijun Ju Wei Wang Jinbao Wei Weidi Wang Mengjing Zhao Khalil Ali Ahmad Yongxiang Wang Jinghong Chen Source Type: research

Increased Homotopic Connectivity in the Prefrontal Cortex Modulated by Olanzapine Predicts Therapeutic Efficacy in Patients with Schizophrenia
CONCLUSIONS: This study demonstrated that olanzapine treatment may normalize decreased homotopic connectivity in the superior/middle MPFC in schizophrenic patients. The VMHC in the superior/middle MPFC may predict individual response for antipsychotic therapy. The findings of this study conduce to the comprehension of the therapy effects of antipsychotic medications on homotopic connectivity in schizophrenia.PMID:34512748 | PMC:PMC8429031 | DOI:10.1155/2021/9954547 (Source: Neural Plasticity)
Source: Neural Plasticity - September 13, 2021 Category: Neurology Authors: Xiaoxiao Shan Rongyuan Liao Yangpan Ou Yudan Ding Feng Liu Jindong Chen Jingping Zhao Yiqun He Wenbin Guo Source Type: research

sLOX-1: A Molecule for Evaluating the Prognosis of Recurrent Ischemic Stroke
In this study, we aimed to explore the relationship between soluble lectin-like oxidized low-density lipoprotein receptor 1 (sLOX-1) levels and the prediction of the functional outcome in patients with recurrent and first-ever stroke. A total of 266 patients with recurrent and first-ever stroke, who underwent follow-up for 3 months, were included in this study. Plasma samples were collected within 24 h after onset. The results showed that biomarkers for the prognosis of patients with recurrent stroke were different from that of those with first-ever stroke. sLOX-1 levels were correlated with modified Rankin Scale scores of...
Source: Neural Plasticity - September 9, 2021 Category: Neurology Authors: Yangmin Zheng Yuyou Huang Lingzhi Li Pingping Wang Rongliang Wang Zhen Tao Junfen Fan Ziping Han Fangfang Li Haiping Zhao Fangfang Zhao Feng Yan Yumei Liu Yumin Luo Source Type: research

sLOX-1: A Molecule for Evaluating the Prognosis of Recurrent Ischemic Stroke
In this study, we aimed to explore the relationship between soluble lectin-like oxidized low-density lipoprotein receptor 1 (sLOX-1) levels and the prediction of the functional outcome in patients with recurrent and first-ever stroke. A total of 266 patients with recurrent and first-ever stroke, who underwent follow-up for 3 months, were included in this study. Plasma samples were collected within 24 h after onset. The results showed that biomarkers for the prognosis of patients with recurrent stroke were different from that of those with first-ever stroke. sLOX-1 levels were correlated with modified Rankin Scale scores of...
Source: Neural Plasticity - September 9, 2021 Category: Neurology Authors: Yangmin Zheng Yuyou Huang Lingzhi Li Pingping Wang Rongliang Wang Zhen Tao Junfen Fan Ziping Han Fangfang Li Haiping Zhao Fangfang Zhao Feng Yan Yumei Liu Yumin Luo Source Type: research

sLOX-1: A Molecule for Evaluating the Prognosis of Recurrent Ischemic Stroke
In this study, we aimed to explore the relationship between soluble lectin-like oxidized low-density lipoprotein receptor 1 (sLOX-1) levels and the prediction of the functional outcome in patients with recurrent and first-ever stroke. A total of 266 patients with recurrent and first-ever stroke, who underwent follow-up for 3 months, were included in this study. Plasma samples were collected within 24 h after onset. The results showed that biomarkers for the prognosis of patients with recurrent stroke were different from that of those with first-ever stroke. sLOX-1 levels were correlated with modified Rankin Scale scores of...
Source: Neural Plasticity - September 9, 2021 Category: Neurology Authors: Yangmin Zheng Yuyou Huang Lingzhi Li Pingping Wang Rongliang Wang Zhen Tao Junfen Fan Ziping Han Fangfang Li Haiping Zhao Fangfang Zhao Feng Yan Yumei Liu Yumin Luo Source Type: research

sLOX-1: A Molecule for Evaluating the Prognosis of Recurrent Ischemic Stroke
In this study, we aimed to explore the relationship between soluble lectin-like oxidized low-density lipoprotein receptor 1 (sLOX-1) levels and the prediction of the functional outcome in patients with recurrent and first-ever stroke. A total of 266 patients with recurrent and first-ever stroke, who underwent follow-up for 3 months, were included in this study. Plasma samples were collected within 24 h after onset. The results showed that biomarkers for the prognosis of patients with recurrent stroke were different from that of those with first-ever stroke. sLOX-1 levels were correlated with modified Rankin Scale scores of...
Source: Neural Plasticity - September 9, 2021 Category: Neurology Authors: Yangmin Zheng Yuyou Huang Lingzhi Li Pingping Wang Rongliang Wang Zhen Tao Junfen Fan Ziping Han Fangfang Li Haiping Zhao Fangfang Zhao Feng Yan Yumei Liu Yumin Luo Source Type: research

Electroacupuncture Improves Clearance of Amyloid- < em > β < /em > through the Glymphatic System in the SAMP8 Mouse Model of Alzheimer's Disease
CONCLUSION: EA treatment might reduce Aβ accumulation from the brain via improving clearance performance of the glymphatic system and thereby alleviating cognitive impairment.PMID:34484327 | PMC:PMC8416373 | DOI:10.1155/2021/9960304 (Source: Neural Plasticity)
Source: Neural Plasticity - September 6, 2021 Category: Neurology Authors: Pei-Zhe Liang Li Li Ya-Nan Zhang Yan Shen Li-Li Zhang Jie Zhou Zhi-Jie Wang Shu Wang Sha Yang Source Type: research

Electroacupuncture Improves Clearance of Amyloid- < em > β < /em > through the Glymphatic System in the SAMP8 Mouse Model of Alzheimer's Disease
CONCLUSION: EA treatment might reduce Aβ accumulation from the brain via improving clearance performance of the glymphatic system and thereby alleviating cognitive impairment.PMID:34484327 | PMC:PMC8416373 | DOI:10.1155/2021/9960304 (Source: Neural Plasticity)
Source: Neural Plasticity - September 6, 2021 Category: Neurology Authors: Pei-Zhe Liang Li Li Ya-Nan Zhang Yan Shen Li-Li Zhang Jie Zhou Zhi-Jie Wang Shu Wang Sha Yang Source Type: research

Suppression of CHOP Reduces Neuronal Apoptosis and Rescues Cognitive Impairment Induced by Intermittent Hypoxia by Inhibiting Bax and Bak Activation
This study is aimed at determining which signaling pathway is activated to induce CHOP and the role of this protein in mitochondria-dependent apoptosis induced by IH. In the in vivo study, mice were placed in IH chambers for 8 h daily over a period of 2 weeks; the IH chambers had oxygen (O2) concentrations that oscillated between 10% and 21%, cycling every 90 s. In the in vitro study, PC12 cells were exposed to 21% O2 (normoxia) or 8 IH cycles (25 min at 21% O2 and 35 min at 0.1% O2 for each cycle). After 2 weeks of IH treatment, we observed that the expression levels of phosphorylated protein kinase-like endoplasmic retic...
Source: Neural Plasticity - September 2, 2021 Category: Neurology Authors: Linhao Xu Yanli Bi Yizhou Xu Yihao Wu Xiaoxue Du Yixuan Mou Jian Chen Source Type: research

Injuries in Left Corticospinal Tracts, Forceps Major, and Left Superior Longitudinal Fasciculus (Temporal) as the Quality Indicators for Major Depressive Disorder
Neural Plast. 2021 Aug 21;2021:2348072. doi: 10.1155/2021/2348072. eCollection 2021.ABSTRACTAt present, the etiology and pathogenesis of major depressive disorder (MDD) are still not clear. Studies have found that the risk of first-degree relatives of MDD is 2-3 times that of the general population. Diffusion tensor imaging (DTI) has been previously used to explore the pathogenesis of MDD. The purpose of this study is to explore the etiology of MDD by DTI and further to explore the correlation between its clinical characteristics and the structural changes of white matter in the brain. The study included 27 first-episode, ...
Source: Neural Plasticity - August 31, 2021 Category: Neurology Authors: Ziwei Liu Lijun Kang Aixia Zhang Chunxia Yang Min Liu Jizhi Wang Penghong Liu Kerang Zhang Ning Sun Source Type: research

Neuroplasticity of Acupuncture for Stroke: An Evidence-Based Review of MRI
Neural Plast. 2021 Aug 19;2021:2662585. doi: 10.1155/2021/2662585. eCollection 2021.ABSTRACTAcupuncture is widely recognized as a potentially effective treatment for stroke rehabilitation. Researchers in this area are actively investigating its therapeutic mechanisms. Magnetic resonance imaging (MRI), as a noninvasive, high anatomical resolution technique, has been employed to investigate neuroplasticity on acupuncture in stroke patients from a system level. However, there is no review on the mechanism of acupuncture treatment for stroke based on MRI. Therefore, we aim to summarize the current evidence about this aspect an...
Source: Neural Plasticity - August 30, 2021 Category: Neurology Authors: Jinhuan Zhang Chunjian Lu Xiaoxiong Wu Dehui Nie Haibo Yu Source Type: research

Neuroplasticity of Acupuncture for Stroke: An Evidence-Based Review of MRI
Neural Plast. 2021 Aug 19;2021:2662585. doi: 10.1155/2021/2662585. eCollection 2021.ABSTRACTAcupuncture is widely recognized as a potentially effective treatment for stroke rehabilitation. Researchers in this area are actively investigating its therapeutic mechanisms. Magnetic resonance imaging (MRI), as a noninvasive, high anatomical resolution technique, has been employed to investigate neuroplasticity on acupuncture in stroke patients from a system level. However, there is no review on the mechanism of acupuncture treatment for stroke based on MRI. Therefore, we aim to summarize the current evidence about this aspect an...
Source: Neural Plasticity - August 30, 2021 Category: Neurology Authors: Jinhuan Zhang Chunjian Lu Xiaoxiong Wu Dehui Nie Haibo Yu Source Type: research

Muscle Fiber Diameter and Density Alterations after Stroke Examined by Single-Fiber EMG
This study presents single-fiber electromyography (EMG) analysis for assessment of paretic muscle changes after stroke. Single-fiber action potentials (SFAPs) were recorded from the first dorsal interosseous (FDI) muscle bilaterally in 12 individuals with hemiparetic stroke. The SFAP parameters, including the negative peak duration and the peak-peak amplitude, were measured and further used to estimate muscle fiber diameter through a model based on the quadratic function. The SFAP parameters, fiber density, and muscle fiber diameter derived from the model were compared between the paretic and contralateral muscles. The res...
Source: Neural Plasticity - August 26, 2021 Category: Neurology Authors: Chengjun Huang Bo Yao Xiaoyan Li Sheng Li Ping Zhou Source Type: research

Improving Clinical, Cognitive, and Psychosocial Dysfunctions in Patients with Schizophrenia: A Neurofeedback Randomized Control Trial
CONCLUSIONS: Neurofeedback can be effectively used as the add-on therapy in schizophrenia rehabilitation programs. The method requires further research regarding its clinical specificity and understanding mechanisms of action.PMID:34434228 | PMC:PMC8380506 | DOI:10.1155/2021/4488664 (Source: Neural Plasticity)
Source: Neural Plasticity - August 26, 2021 Category: Neurology Authors: Renata Markiewicz Agnieszka Markiewicz-Gospodarek Beata Dobrowolska Bartosz Łoza Source Type: research

Destructive Effects of Pyroptosis on Homeostasis of Neuron Survival Associated with the Dysfunctional BBB-Glymphatic System and Amyloid-Beta Accumulation after Cerebral Ischemia/Reperfusion in Rats
Neural Plast. 2021 Aug 14;2021:4504363. doi: 10.1155/2021/4504363. eCollection 2021.ABSTRACTNeuroinflammation-related amyloid-beta peptide (Aβ) accumulation after cerebral ischemia/reperfusion (I/R) accounts for cerebral I/R injuries and poststroke dementia. Recently, pyroptosis, a proinflammatory cell death, has been identified as a crucial pathological link of cerebral I/R injuries. However, whether pyroptosis acts as a trigger of Aβ accumulation after cerebral I/R has not yet been demonstrated. Blood-brain barrier (BBB) and glymphatic system mediated by aquaporin-4 (AQP-4) on astrocytic endfeet are important p...
Source: Neural Plasticity - August 26, 2021 Category: Neurology Authors: Zhongkuan Lyu Yuanjin Chan Qiyue Li Qiang Zhang Kaili Liu Jun Xiang Xiangting Li Dingfang Cai Yaming Li Bing Wang Zhonghai Yu Source Type: research

Contribution of Neuronal and Glial Two-Pore-Domain Potassium Channels in Health and Neurological Disorders
We describe recently discovered functions of K2P channels in glia, such as astrocytic passive conductance and glutamate release, microglial surveillance, and myelin generation by oligodendrocytes. We also discuss the potential role of glial K2P channels in neurological disorders. In the end, we discuss current limitations in K2P channel researches and suggest directions for future studies.PMID:34434230 | PMC:PMC8380499 | DOI:10.1155/2021/8643129 (Source: Neural Plasticity)
Source: Neural Plasticity - August 26, 2021 Category: Neurology Authors: Yuncheng Luo Lu Huang Ping Liao Ruotian Jiang Source Type: research

Role of NADPH Oxidase-Induced Hypoxia-Induced Factor-1 < em > α < /em > Increase in Blood-Brain Barrier Disruption after 2-Hour Focal Ischemic Stroke in Rat
This study is aimed at investigating the role of NADPH oxidase in BBB injury and the expression of HIF-1α after acute ischemic stroke. A sutured middle cerebral artery occlusion (MCAO) model was used to mimic ischemic stroke in rats. Our results show that the inhibition of NADPH oxidase by apocynin can significantly reduce the BBB damage caused by 2 h ischemic stroke accompanied by reducing the degradation of tight junction protein occludin. In addition, treatment with apocynin significantly decreased the upregulation of HIF-1α induced by 2 h MCAO. More importantly, apocynin could also inhibit the MMP-2 upregul...
Source: Neural Plasticity - August 26, 2021 Category: Neurology Authors: Yanping Wang Yufei Shen Xin Yu Jingxia Gu Xiaoling Zhang Beiqun Zhou Yanyun Sun Congying Xu Shuxia Qian Source Type: research

Spatial Learning Is Associated with Antagonist Outcomes for DNA Methylation and DNA Hydroxymethylation in the Transcriptional Regulation of the Ryanodine Receptor 3
Neural Plast. 2021 Aug 11;2021:9930962. doi: 10.1155/2021/9930962. eCollection 2021.ABSTRACTIncreasing attention has been drawn to the role that intracellular calcium stores play in neuronal function. Ryr3 is an intracellular calcium channel that contributes to hippocampal long-term potentiation, dendritic spine function, and higher cognitive processes. Interestingly, stimuli that increase neuronal activity upregulate the transcriptional activity of Ryr3 and augment DNA methylation in its proximal promoter. However, if these observations are valid for complex behavioral tasks such as learning and memory remains being evalu...
Source: Neural Plasticity - August 26, 2021 Category: Neurology Authors: Rodrigo F Torres Bredford Kerr Source Type: research

Muscle Fiber Diameter and Density Alterations after Stroke Examined by Single-Fiber EMG
This study presents single-fiber electromyography (EMG) analysis for assessment of paretic muscle changes after stroke. Single-fiber action potentials (SFAPs) were recorded from the first dorsal interosseous (FDI) muscle bilaterally in 12 individuals with hemiparetic stroke. The SFAP parameters, including the negative peak duration and the peak-peak amplitude, were measured and further used to estimate muscle fiber diameter through a model based on the quadratic function. The SFAP parameters, fiber density, and muscle fiber diameter derived from the model were compared between the paretic and contralateral muscles. The res...
Source: Neural Plasticity - August 26, 2021 Category: Neurology Authors: Chengjun Huang Bo Yao Xiaoyan Li Sheng Li Ping Zhou Source Type: research

Improving Clinical, Cognitive, and Psychosocial Dysfunctions in Patients with Schizophrenia: A Neurofeedback Randomized Control Trial
CONCLUSIONS: Neurofeedback can be effectively used as the add-on therapy in schizophrenia rehabilitation programs. The method requires further research regarding its clinical specificity and understanding mechanisms of action.PMID:34434228 | PMC:PMC8380506 | DOI:10.1155/2021/4488664 (Source: Neural Plasticity)
Source: Neural Plasticity - August 26, 2021 Category: Neurology Authors: Renata Markiewicz Agnieszka Markiewicz-Gospodarek Beata Dobrowolska Bartosz Łoza Source Type: research

Destructive Effects of Pyroptosis on Homeostasis of Neuron Survival Associated with the Dysfunctional BBB-Glymphatic System and Amyloid-Beta Accumulation after Cerebral Ischemia/Reperfusion in Rats
Neural Plast. 2021 Aug 14;2021:4504363. doi: 10.1155/2021/4504363. eCollection 2021.ABSTRACTNeuroinflammation-related amyloid-beta peptide (Aβ) accumulation after cerebral ischemia/reperfusion (I/R) accounts for cerebral I/R injuries and poststroke dementia. Recently, pyroptosis, a proinflammatory cell death, has been identified as a crucial pathological link of cerebral I/R injuries. However, whether pyroptosis acts as a trigger of Aβ accumulation after cerebral I/R has not yet been demonstrated. Blood-brain barrier (BBB) and glymphatic system mediated by aquaporin-4 (AQP-4) on astrocytic endfeet are important p...
Source: Neural Plasticity - August 26, 2021 Category: Neurology Authors: Zhongkuan Lyu Yuanjin Chan Qiyue Li Qiang Zhang Kaili Liu Jun Xiang Xiangting Li Dingfang Cai Yaming Li Bing Wang Zhonghai Yu Source Type: research

Contribution of Neuronal and Glial Two-Pore-Domain Potassium Channels in Health and Neurological Disorders
We describe recently discovered functions of K2P channels in glia, such as astrocytic passive conductance and glutamate release, microglial surveillance, and myelin generation by oligodendrocytes. We also discuss the potential role of glial K2P channels in neurological disorders. In the end, we discuss current limitations in K2P channel researches and suggest directions for future studies.PMID:34434230 | PMC:PMC8380499 | DOI:10.1155/2021/8643129 (Source: Neural Plasticity)
Source: Neural Plasticity - August 26, 2021 Category: Neurology Authors: Yuncheng Luo Lu Huang Ping Liao Ruotian Jiang Source Type: research

Role of NADPH Oxidase-Induced Hypoxia-Induced Factor-1 < em > α < /em > Increase in Blood-Brain Barrier Disruption after 2-Hour Focal Ischemic Stroke in Rat
This study is aimed at investigating the role of NADPH oxidase in BBB injury and the expression of HIF-1α after acute ischemic stroke. A sutured middle cerebral artery occlusion (MCAO) model was used to mimic ischemic stroke in rats. Our results show that the inhibition of NADPH oxidase by apocynin can significantly reduce the BBB damage caused by 2 h ischemic stroke accompanied by reducing the degradation of tight junction protein occludin. In addition, treatment with apocynin significantly decreased the upregulation of HIF-1α induced by 2 h MCAO. More importantly, apocynin could also inhibit the MMP-2 upregul...
Source: Neural Plasticity - August 26, 2021 Category: Neurology Authors: Yanping Wang Yufei Shen Xin Yu Jingxia Gu Xiaoling Zhang Beiqun Zhou Yanyun Sun Congying Xu Shuxia Qian Source Type: research

Spatial Learning Is Associated with Antagonist Outcomes for DNA Methylation and DNA Hydroxymethylation in the Transcriptional Regulation of the Ryanodine Receptor 3
Neural Plast. 2021 Aug 11;2021:9930962. doi: 10.1155/2021/9930962. eCollection 2021.ABSTRACTIncreasing attention has been drawn to the role that intracellular calcium stores play in neuronal function. Ryr3 is an intracellular calcium channel that contributes to hippocampal long-term potentiation, dendritic spine function, and higher cognitive processes. Interestingly, stimuli that increase neuronal activity upregulate the transcriptional activity of Ryr3 and augment DNA methylation in its proximal promoter. However, if these observations are valid for complex behavioral tasks such as learning and memory remains being evalu...
Source: Neural Plasticity - August 26, 2021 Category: Neurology Authors: Rodrigo F Torres Bredford Kerr Source Type: research

Muscle Fiber Diameter and Density Alterations after Stroke Examined by Single-Fiber EMG
This study presents single-fiber electromyography (EMG) analysis for assessment of paretic muscle changes after stroke. Single-fiber action potentials (SFAPs) were recorded from the first dorsal interosseous (FDI) muscle bilaterally in 12 individuals with hemiparetic stroke. The SFAP parameters, including the negative peak duration and the peak-peak amplitude, were measured and further used to estimate muscle fiber diameter through a model based on the quadratic function. The SFAP parameters, fiber density, and muscle fiber diameter derived from the model were compared between the paretic and contralateral muscles. The res...
Source: Neural Plasticity - August 26, 2021 Category: Neurology Authors: Chengjun Huang Bo Yao Xiaoyan Li Sheng Li Ping Zhou Source Type: research

Improving Clinical, Cognitive, and Psychosocial Dysfunctions in Patients with Schizophrenia: A Neurofeedback Randomized Control Trial
CONCLUSIONS: Neurofeedback can be effectively used as the add-on therapy in schizophrenia rehabilitation programs. The method requires further research regarding its clinical specificity and understanding mechanisms of action.PMID:34434228 | PMC:PMC8380506 | DOI:10.1155/2021/4488664 (Source: Neural Plasticity)
Source: Neural Plasticity - August 26, 2021 Category: Neurology Authors: Renata Markiewicz Agnieszka Markiewicz-Gospodarek Beata Dobrowolska Bartosz Łoza Source Type: research

Destructive Effects of Pyroptosis on Homeostasis of Neuron Survival Associated with the Dysfunctional BBB-Glymphatic System and Amyloid-Beta Accumulation after Cerebral Ischemia/Reperfusion in Rats
Neural Plast. 2021 Aug 14;2021:4504363. doi: 10.1155/2021/4504363. eCollection 2021.ABSTRACTNeuroinflammation-related amyloid-beta peptide (Aβ) accumulation after cerebral ischemia/reperfusion (I/R) accounts for cerebral I/R injuries and poststroke dementia. Recently, pyroptosis, a proinflammatory cell death, has been identified as a crucial pathological link of cerebral I/R injuries. However, whether pyroptosis acts as a trigger of Aβ accumulation after cerebral I/R has not yet been demonstrated. Blood-brain barrier (BBB) and glymphatic system mediated by aquaporin-4 (AQP-4) on astrocytic endfeet are important p...
Source: Neural Plasticity - August 26, 2021 Category: Neurology Authors: Zhongkuan Lyu Yuanjin Chan Qiyue Li Qiang Zhang Kaili Liu Jun Xiang Xiangting Li Dingfang Cai Yaming Li Bing Wang Zhonghai Yu Source Type: research

Contribution of Neuronal and Glial Two-Pore-Domain Potassium Channels in Health and Neurological Disorders
We describe recently discovered functions of K2P channels in glia, such as astrocytic passive conductance and glutamate release, microglial surveillance, and myelin generation by oligodendrocytes. We also discuss the potential role of glial K2P channels in neurological disorders. In the end, we discuss current limitations in K2P channel researches and suggest directions for future studies.PMID:34434230 | PMC:PMC8380499 | DOI:10.1155/2021/8643129 (Source: Neural Plasticity)
Source: Neural Plasticity - August 26, 2021 Category: Neurology Authors: Yuncheng Luo Lu Huang Ping Liao Ruotian Jiang Source Type: research

Role of NADPH Oxidase-Induced Hypoxia-Induced Factor-1 < em > α < /em > Increase in Blood-Brain Barrier Disruption after 2-Hour Focal Ischemic Stroke in Rat
This study is aimed at investigating the role of NADPH oxidase in BBB injury and the expression of HIF-1α after acute ischemic stroke. A sutured middle cerebral artery occlusion (MCAO) model was used to mimic ischemic stroke in rats. Our results show that the inhibition of NADPH oxidase by apocynin can significantly reduce the BBB damage caused by 2 h ischemic stroke accompanied by reducing the degradation of tight junction protein occludin. In addition, treatment with apocynin significantly decreased the upregulation of HIF-1α induced by 2 h MCAO. More importantly, apocynin could also inhibit the MMP-2 upregul...
Source: Neural Plasticity - August 26, 2021 Category: Neurology Authors: Yanping Wang Yufei Shen Xin Yu Jingxia Gu Xiaoling Zhang Beiqun Zhou Yanyun Sun Congying Xu Shuxia Qian Source Type: research

Spatial Learning Is Associated with Antagonist Outcomes for DNA Methylation and DNA Hydroxymethylation in the Transcriptional Regulation of the Ryanodine Receptor 3
Neural Plast. 2021 Aug 11;2021:9930962. doi: 10.1155/2021/9930962. eCollection 2021.ABSTRACTIncreasing attention has been drawn to the role that intracellular calcium stores play in neuronal function. Ryr3 is an intracellular calcium channel that contributes to hippocampal long-term potentiation, dendritic spine function, and higher cognitive processes. Interestingly, stimuli that increase neuronal activity upregulate the transcriptional activity of Ryr3 and augment DNA methylation in its proximal promoter. However, if these observations are valid for complex behavioral tasks such as learning and memory remains being evalu...
Source: Neural Plasticity - August 26, 2021 Category: Neurology Authors: Rodrigo F Torres Bredford Kerr Source Type: research

Muscle Fiber Diameter and Density Alterations after Stroke Examined by Single-Fiber EMG
This study presents single-fiber electromyography (EMG) analysis for assessment of paretic muscle changes after stroke. Single-fiber action potentials (SFAPs) were recorded from the first dorsal interosseous (FDI) muscle bilaterally in 12 individuals with hemiparetic stroke. The SFAP parameters, including the negative peak duration and the peak-peak amplitude, were measured and further used to estimate muscle fiber diameter through a model based on the quadratic function. The SFAP parameters, fiber density, and muscle fiber diameter derived from the model were compared between the paretic and contralateral muscles. The res...
Source: Neural Plasticity - August 26, 2021 Category: Neurology Authors: Chengjun Huang Bo Yao Xiaoyan Li Sheng Li Ping Zhou Source Type: research

Improving Clinical, Cognitive, and Psychosocial Dysfunctions in Patients with Schizophrenia: A Neurofeedback Randomized Control Trial
CONCLUSIONS: Neurofeedback can be effectively used as the add-on therapy in schizophrenia rehabilitation programs. The method requires further research regarding its clinical specificity and understanding mechanisms of action.PMID:34434228 | PMC:PMC8380506 | DOI:10.1155/2021/4488664 (Source: Neural Plasticity)
Source: Neural Plasticity - August 26, 2021 Category: Neurology Authors: Renata Markiewicz Agnieszka Markiewicz-Gospodarek Beata Dobrowolska Bartosz Łoza Source Type: research

Destructive Effects of Pyroptosis on Homeostasis of Neuron Survival Associated with the Dysfunctional BBB-Glymphatic System and Amyloid-Beta Accumulation after Cerebral Ischemia/Reperfusion in Rats
Neural Plast. 2021 Aug 14;2021:4504363. doi: 10.1155/2021/4504363. eCollection 2021.ABSTRACTNeuroinflammation-related amyloid-beta peptide (Aβ) accumulation after cerebral ischemia/reperfusion (I/R) accounts for cerebral I/R injuries and poststroke dementia. Recently, pyroptosis, a proinflammatory cell death, has been identified as a crucial pathological link of cerebral I/R injuries. However, whether pyroptosis acts as a trigger of Aβ accumulation after cerebral I/R has not yet been demonstrated. Blood-brain barrier (BBB) and glymphatic system mediated by aquaporin-4 (AQP-4) on astrocytic endfeet are important p...
Source: Neural Plasticity - August 26, 2021 Category: Neurology Authors: Zhongkuan Lyu Yuanjin Chan Qiyue Li Qiang Zhang Kaili Liu Jun Xiang Xiangting Li Dingfang Cai Yaming Li Bing Wang Zhonghai Yu Source Type: research

Contribution of Neuronal and Glial Two-Pore-Domain Potassium Channels in Health and Neurological Disorders
We describe recently discovered functions of K2P channels in glia, such as astrocytic passive conductance and glutamate release, microglial surveillance, and myelin generation by oligodendrocytes. We also discuss the potential role of glial K2P channels in neurological disorders. In the end, we discuss current limitations in K2P channel researches and suggest directions for future studies.PMID:34434230 | PMC:PMC8380499 | DOI:10.1155/2021/8643129 (Source: Neural Plasticity)
Source: Neural Plasticity - August 26, 2021 Category: Neurology Authors: Yuncheng Luo Lu Huang Ping Liao Ruotian Jiang Source Type: research