The influence of biofilm maturation on fluoride ’s anticaries efficacy
ConclusionEarlier exposure to SnF2 and AmF may result in less tolerant biofilm. Early fluoride treatment may produce a protective effect against demineralization. SnF2 and AmF may be the choice to treat older biofilm and prevent biofilm recovery.Clinical relevanceThe study provides an understanding of biofilm-fluoride interaction with mature biofilm (e.g., hard-to-reach areas, orthodontic patients) and fluoride ’s sustainable effect hours/days after brushing. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - July 30, 2021 Category: Dentistry Source Type: research

Two-thirds anteroposterior ramus length is the preferred osteotomy point for intraoral vertical ramus osteotomy
ConclusionsThe position at two-thirds EOR-PBR length (anteroposterior diameter of the ramus) can serve as a reference distance for the IVRO osteotomy position.Clinical relevanceMandibular setback operations for treating mandibular prognathism mainly include sagittal split ramus osteotomy (SSRO) and IVRO. IVRO has a markedly lower incidence of postoperative lower lip paraesthesia than SSRO. Our design presented a reference point for identification during IVRO, to prevent damage to the inferior alveolar neurovascular bundle. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - July 30, 2021 Category: Dentistry Source Type: research

Comparison of the expression of the volumetric alteration artifact in cylindrical and triangular fields of view in two cone-beam computed tomography devices
AbstractObjectiveTo compare the expression of the volumetric alteration (VA) artifact between cylindrical and convex triangular fields of view (FOVs) using high-density materials in different positions in two cone-beam computed tomography (CBCT) devices.Materials and methodsCylinders of five high-density materials (amalgam, chromium-cobalt, gutta-percha, titanium, and zirconium) with known physical volume were individually submitted to CBCT acquisition in four positions inside a polymethylmethacrylate phantom using two different FOV shapes (convex triangular and cylindrical) on the Veraviewepocs ® R100 (R100) and Verav...
Source: Clinical Oral Investigations - July 29, 2021 Category: Dentistry Source Type: research

Systemic burden and cardiovascular risk to Porphyromonas species in apical periodontitis
This study explored the associations between endodontic infection withPorphyromonas species, the systemic bacterial burden, and cardiovascular risk, based on high-sensitivity C-reactive protein (hsCRP), in young adults with AP.Materials and methodsCross-sectional study. Otherwise, healthy individuals with AP and controls (n = 80, ≤ 40 years) were recruited at the University Dental Clinic. Oral parameters and classic cardiovascular risk factors were registered. EndodonticPorphyromonas endodontalis andPorphyromonas gingivalis were identified using conventional PCR. Serum concentrations of ...
Source: Clinical Oral Investigations - July 27, 2021 Category: Dentistry Source Type: research

Deep learning-based evaluation of the relationship between mandibular third molar and mandibular canal on CBCT
ConclusionsOur approach based on CNNs demonstrated an encouraging performance for the automatic detection and evaluation of the M3 and MC on CBCT.Clinical relevanceAn automated approach based on CNNs for detection and evaluation of M3 and MC on CBCT has been established, which can be utilized to improve diagnostic efficiency and facilitate the precision diagnosis and treatment of M3. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - July 27, 2021 Category: Dentistry Source Type: research

The impact of splinting timepoint of mobile mandibular incisors on the outcome of periodontal treatment —preliminary observations from a randomized clinical trial
ConclusionsTeeth splinted before or after FMD show a significant improvement in periodontal parameters 12  months after FMD. Splinting after FMD offered the option to detect reduction in mobility.Clinical relevanceDespite a higher, but not statistically significant, improvement in periodontal parameters on teeth splinted before FMD, the results do not indicate which timepoint of splinting is more beneficial. The decision for the therapeutic procedure should therefore be made individually. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - July 26, 2021 Category: Dentistry Source Type: research

Needs for re-intervention on restored teeth in adults: a practice-based study
ConclusionsThe needs for re-intervention in adults are still high within a context of ever-changing materials and techniques, simplified and rationalized decision-makings, and demands for patient involvement.Clinical relevanceMeeting these needs requires the following: (i) consensus definitions and assessment methods for “failure” and (ii) reliable feedbacks on materials, procedures, and satisfaction. Building large and detailed databases fed by networks of motivated practitioners will help analyzing complex success/failure data by artificial intelligence and guiding treatment and research. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - July 24, 2021 Category: Dentistry Source Type: research

Retrospective fractal analyses of one-year follow-up data obtained after single-visit nonsurgical endodontic retreatment on periapical radiographs
AbstractObjectivesThe aim of retrospective study was to evaluate the changes to the periapical bone sites after non-surgical endodontic retreatment by using fractal analysis on periapical radiographs.Materials and methodsThirty patients whose teeth had periapical lesions and underwent primary endodontic treatment were selected for nonsurgical single-visit endodontic retreatment. Two radiographs were taken, the first immediately after retreatment and the second at the 1-year follow-up. An identical region of interest close to the infected root apex was selected from each radiograph. FD was measured using the box-counting me...
Source: Clinical Oral Investigations - July 24, 2021 Category: Dentistry Source Type: research

Can Kinesio taping improve discomfort after mandibular third molar surgery? A systematic review and meta-analysis
AbstractObjectiveThe purpose of this study was to evaluate whether Kinesio taping (KT) can improve patient discomfort after mandibular third molar surgery.Materials and methodsThis systematic review and meta-analysis was conducted according to the PICO strategy. We searched 4 databases for related articles. All controlled trials or randomized controlled trials that evaluated the application of KT after mandibular third molar surgery were included. Screening and article selection were carried out by two independent reviewers. The main evaluation indicators were facial swelling, pain, and trismus. All statistical analyses we...
Source: Clinical Oral Investigations - July 23, 2021 Category: Dentistry Source Type: research

Sealing of cavitated occlusal carious lesions in the dentine of deciduous molars: a two-year randomised controlled clinical trial
AbstractObjectivesThis two-arm, parallel-group, tooth-randomised, controlled noninferiority clinical trial aimed to compare survival rates between the sealing and restoring of cavitated occlusal carious lesions in dentine [International Caries Detection and Assessment System (ICDAS) 5] of deciduous molars using resin-modified glass-ionomer cement (RMGIC) and to assess caries progression radiographically.Materials and methodsA total of 68 molars with ICDAS 5 occlusal lesions were randomly allocated into two groups, a sealing group (n  = 31), in which RMGIC was placed directly over the carious lesion, and a res...
Source: Clinical Oral Investigations - July 21, 2021 Category: Dentistry Source Type: research

Effect of an elastomeric urethane monomer on BisGMA-free resin composites containing different co-initiators
ConclusionsAmong the combinations tested, the BisGMA-free resin composite containing Exothane-24 combined with the DMPOH co-initiator showed the best mechanical, chemical, optical, and adhesive properties.Clinical relevanceExothane-24 monomer and DMPOH co-initiator could be useful in the formulation of BisGMA-free resin composites in order to minimize exposure to BPA. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - July 21, 2021 Category: Dentistry Source Type: research

Correction to: Temporary materials: comparison of in vivo and in vitro performance
A Correction to this paper has been published:https://doi.org/10.1007/s00784-021-04067-4 (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - July 21, 2021 Category: Dentistry Source Type: research

Effect of locally delivered adjunctive antibiotics during surgical periodontal therapy: a systematic review and meta-analysis
ConclusionWithin the current review ’s limitations, locally delivered antibiotics during surgical periodontal therapy results in post-surgical improvements for CAL, PPD, and BOP (≤6 months) with a longer-lasting GI improvement. Further randomized controlled trials are needed with true periodontal end-points to assess the ideal ant ibiotic agent, dosage, and delivery methods.Clinical relevanceLocal delivery of antibiotics during periodontal surgery improved clinical parameters for up to 6-month follow-up, with beneficial longer effects on gingival inflammation. Within the current study ’s limitation, the pres...
Source: Clinical Oral Investigations - July 20, 2021 Category: Dentistry Source Type: research

Oral health-related quality of life in patients with early rheumatoid arthritis is associated with periodontal inflammation and painful temporomandibular disorders: a cross-sectional study
AbstractObjectivesTo evaluate oral health-related quality of life (OHRQoL) in early rheumatoid arthritis (ERA) patients and individuals at risk of rheumatoid arthritis (RA) compared to healthy controls, and to explore possible associated factors.Materials and methodsFifty ERA patients, 50 at-risk individuals, and 50 age and gender matched healthy controls were recruited. OHRQoL (Oral Health Impact Profile-14 (OHIP-14)); number of decayed, missing, and filled teeth (DMFT); denture use; periodontal inflamed surface area (PISA); xerostomia (xerostomia inventory (XI)); and possible TMD (-pain) diagnoses were recorded. The grou...
Source: Clinical Oral Investigations - July 19, 2021 Category: Dentistry Source Type: research

Do anatomical variations of the mandibular canal pose an increased risk of inferior alveolar nerve injury after third molar removal?
ConclusionIn the present study, the assessed mandibular canal variations had limited predictive value for IAN neurosensory disturbances following third molar removal.Clinical relevanceWhile a close relation between the third molar and the mandibular canal remains a high risk factor, mandibular canal variations did not pose an increased risk of postoperative IAN injury after third molar removal. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - July 19, 2021 Category: Dentistry Source Type: research

3D printing in oral and maxillofacial surgery: a nationwide survey among university and non-university hospitals and private practices in Germany
ConclusionsOMFS 3D printing is established in Germany with a wide range of applications.Clinical relevanceThe prevalence of 3D printing in hospitals and private practices is moderate. This may be enhanced by future innovations including improved cost efficiency. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - July 19, 2021 Category: Dentistry Source Type: research

Residual periodontal pocket treatment with Er:YAG laser-assisted comprehensive periodontal pocket therapy: a retrospective study
AbstractObjectivesRecently, the application of erbium-doped yttrium aluminum garnet (Er:YAG) laser has been increasing in periodontal therapy. In this retrospective study, we evaluated the safety and effectiveness of a novel pocket therapy using Er:YAG laser in combination with conventional mechanical scaling and root planing treatment (Er:YAG laser-assisted comprehensive periodontal pocket therapy).MethodsForty sites in 29 elderly patients having residual periodontal pockets of  ≥ 5 mm depth were treated by curette and Er:YAG laser from 2006 to 2009. After root debridement by curette, laser irradiati...
Source: Clinical Oral Investigations - July 19, 2021 Category: Dentistry Source Type: research

Diagnostic accuracy of CBCT compared to panoramic radiography in predicting IAN exposure: a systematic review and meta-analysis
AbstractObjectivesThe aim of this study is to verify whether the diagnostic accuracy of cone beam computed tomography (CBCT) is superior to panoramic radiography (PR) in predicting inferior alveolar nerve (IAN) exposure during the lower third molar extraction.Materials and methodsEight electronic databases were searched up to September 2020. Studies that evaluated the accuracy (sensitivity, specificity, positive-predictive value, and negative predictive value) of both imaging methods were included. The gold standard was the visualization of the IAN exposure during the extraction of lower third molars. The gray literature w...
Source: Clinical Oral Investigations - July 17, 2021 Category: Dentistry Source Type: research

Three-dimensional craniofacial characteristics associated with obstructive sleep apnea severity and treatment outcomes
ConclusionsThe transversal frontomaxillary suture width and the mandibular ramus facial angle may influence OSA severity. The gonial angle, volume, and area of all UA regions may indicate the amount of protrusion needed for successful MAD treatment.Clinical relevanceThe craniofacial characteristics reported as important factors for OSA severity and MAD treatment outcomes impact therapy planning for OSA patients, considering individual anatomic characteristics, prognosis, and cost benefits. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - July 17, 2021 Category: Dentistry Source Type: research

Colorimetric evaluation after in-office tooth bleaching with violet LED: 6- and 12-month follow-ups of a randomized clinical trial
The objective color (ΔEab, ΔE00) and whiteness index ( ΔWID) changes were calculated applying the CIELab coordinates ’ values obtained using a spectrophotometer. A visual shade guide determined the tooth’s subjective color change (ΔSGU). Data were submitted to one-way ANOVA or Welch’s ANOVA, following appropriate post hoc tests (α = 5%).ResultsThe LED and CP groups exhibited the lowest ΔEab, ΔE00, and ΔSGU (p 
Source: Clinical Oral Investigations - July 16, 2021 Category: Dentistry Source Type: research

Comparison of RANKL and OPG levels in peri-implant crevicular fluid between healthy and diseased peri-implant tissues. A systematic review and meta-analysis
ConclusionsThere is limited evidence that levels of the examined biomarkers, RANKL, and OPG as well as the RANKL/OPG ratio, in PICF, may be considered strong indicators for distinguishing between healthy and inflamed peri-implant sites.Clinical relevanceBiomarker identification in PICF, which could differentiate between healthy and diseased dental implants, might represent a valuable non-invasive method suitable for implant pathology and implant therapy prognosis. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - July 15, 2021 Category: Dentistry Source Type: research

Long-term dentoskeletal side  effects of mandibular advancement therapy in patients with obstructive sleep apnea: data from the Pays de la Loire sleep cohort
ConclusionsLong-term dentoskeletal side  effects were mainly moderate dental side effects. Some predictive factors were shown to be associated with more pronounced changes. Subjective side effects did not appear to be reliable tools to detect dentoskeletal side effects.Clinical relevanceRegular follow-up with clinical examination and regular radiographs is mandatory. The predictive factors could be of interest for a better selection of patients and to individualize follow-up. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - July 14, 2021 Category: Dentistry Source Type: research

Influence of caries and molar incisor hypomineralization on oral health-related quality of life in children
ConclusionWith increasing severity, both clinical conditions showed a greater negative impact on OHRQoL. MIH was associated with more impairments.Clinical relevanceCurrently, the focus in pediatric dentistry is placed on the prevention and treatment of caries. Both diseases may have a negative influence on OHRQoL. Since children perceive the impairments by MIH as worse and the prevalence is equal to that of caries, which focus might be shifted in the future. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - July 14, 2021 Category: Dentistry Source Type: research

Caries lesion transition patterns of schoolchildren in a fluoridated community in Brazil
ConclusionThe caries lesion transition pattern in this child population exposed to water fluoride and fluoride toothpaste showed that a low proportion of sound surfaces and non-cavitated lesions progressed to cavitation within the 2-year follow-up. Caries arrest was mainly ascribed to a high proportion of active non-cavitated lesions regressing to sound or inactive lesions.Clinical relevanceCaries activity can be controlled by regular exposure to fluoridated water and fluoridated toothpaste. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - July 14, 2021 Category: Dentistry Source Type: research

Evaluation of the three-dimensional (3D) position of cervical vertebrae in individuals with unilateral posterior crossbite
AbstractObjectiveTo evaluate the three-dimensional (3D) position of the cervical vertebrae of growing subjects with unilateral posterior crossbite (UPC).Materials and methodsIn this cross-sectional study, cone beam computed tomography (CBCT) scans of 1455 patients were screened, and ultimately 58 scans (26 patients with UPC and 32 controls with normal occlusion) were included after imposing inclusion/exclusion criteria. Roll, yaw, and deviation of the geometric center of C1, C2, and C3 vertebrae were measured and compared between groups. A correlation between these parameters and different variables on mandibular positioni...
Source: Clinical Oral Investigations - July 13, 2021 Category: Dentistry Source Type: research

Clinical influence of calcium hydroxide intracanal medications on matrix metalloproteinases and tissue inhibitors of metalloproteinases in apical periodontitis
This study investigated the influence of calcium hydroxide intracanal medications on the levels of metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in apical periodontitis (AP).Materials and methodsTwenty primarily infected root canals with AP were randomly divided into two groups: Ca(OH)2 + sterile saline solution (SSL) group and Ca(OH)2 + 2% chlorhexidine gel (CHX gel) group. We collected samples from the periradicular tissue fluid (PTF) before (s1) and after 14 days of intracanal medication (s2). MMP-1, MMP-2, MMP-9, TIMP-1, and TIMP-2 were measured by ELISA assay.ResultsMMP...
Source: Clinical Oral Investigations - July 13, 2021 Category: Dentistry Source Type: research

Motivational interviewing for caries prevention in adolescents: a randomized controlled trial
ConclusionMI outperformed prevailing health education in improving oral health behaviors and preventing dental caries among adolescents.Clinical relevanceIncorporating MI into dental care for caries-prone adolescents contributes to optimal health outcomes.Trial registrationHKUCTR-1852 (http://www.hkuctr.com/) (Hong Kong, 2013) (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - July 13, 2021 Category: Dentistry Source Type: research

Clinical and biochemical evaluation of oral irrigation in patients with peri-implant mucositis: a randomized clinical trial
AbstractObjectiveThis randomized clinical trial aimed to compare the efficacy of an oral irrigator and an interdental brush in patients with peri-implant mucositis clinically and biochemically at different time points (at baseline and at the 2nd, 4th, and 12th weeks).Materials and methodsForty-five patients with at least one implant with peri-implant mucositis were included in the present study (n  = 45). The patients were divided into three groups: oral irrigator + toothbrush (OI group, n = 15), interdental brush + toothbrush (IB group, n = 15), and too...
Source: Clinical Oral Investigations - July 12, 2021 Category: Dentistry Source Type: research

Analysis of the psychopathological profile, quality of life, and cost-effectiveness of oral lichen planus patients treated with photobiomodulation
ConclusionsPsychological distress was not improved after both treatments and PBM is as effective as corticoids in promoting a better quality of life in OLP patients, despite its higher cost.Clinical relevanceThis study highlights the need for additional therapeutic interventions in OLP patients, to early recognize and to manage the alterations in their psychological profile. Moreover, PBM is an effective therapy in OLP patient ’s quality of live and although it was a more expensive, the advantage of being a minimally invasive therapy associated with no side effects must be considered in clinical practice, especially ...
Source: Clinical Oral Investigations - July 12, 2021 Category: Dentistry Source Type: research

Salivary IL-8 as a putative predictive biomarker of radiotherapy response in head and neck cancer patients
ConclusionsAfter analyzing the panel of salivary cytokines, IL-8 showed the best association to the response to radiotherapy; in this sense, low IL-8 levels in the saliva of HNC patients before receiving irradiation therapy are associated with positive RT outcomes.Clinical relevanceSalivary IL-8 expression in HNC patients undergoing RT may serve as a potential predictive biomarker of response to the treatment. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - July 12, 2021 Category: Dentistry Source Type: research

In vivo evaluation of whitening toothpaste efficiency and patient treatment satisfaction: a randomized controlled trial
ConclusionsWhitening toothpastes can show perceptibly whitening effect after a short time of usage, but without a long-lasting impact.Clinical relevanceToothpaste containing a combination of enzymes and peroxides showed the best whitening performance compared to those containing only enzymes, peroxides, or abrasives.Trial registrationClinicalTrials.gov: NCT04460755 (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - July 10, 2021 Category: Dentistry Source Type: research

Children ’s dental treatment requirements of first permanent molars with poor prognosis
AbstractObjectivesThis retrospective study aimed to (i) survey the correlation between decayed, missing, filled teeth (DMFT), and presence of first permanent molars (FPMs) with poor prognosis and (ii) evaluate the treatment requirements.Materials and methodsSeven hundred seventy-three children with fully erupted FPMs were included in this study. DMFT for the permanent dentition, FPMs, and Global DMFT were evaluated based on clinical and radiographic evaluation. The ratio of deep dentin caries (DDC) and apical lesion presence among FPMs, including treatment requirements, were analysed. Spearman rank correlation coefficient ...
Source: Clinical Oral Investigations - July 9, 2021 Category: Dentistry Source Type: research

Restoration of 1325 teeth with partial-coverage crowns manufactured from high noble metal alloys: a retrospective case series 18.8  years after prosthetic delivery
ConclusionPartial-coverage crowns from high noble metal alloys showed excellent survival and success rates after a mean observation period of 18.8  ± 5.7 years. Higher patient age was one of the risk factors.Clinical RelevanceAccording to the results of this study, hnPCCs still represent an excellent therapeutic option —even in modern dentistry. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - July 9, 2021 Category: Dentistry Source Type: research

Influence of post type on periapical status: a prospective study in a Brazilian population
ConclusionsThe tested posts presented similar endodontic healing. Precautions taken during endodontic therapy, post cementation, and final restoration are more likely to be responsible for the success of endodontic treatment rather than a specific type of post.Clinical relevanceThe type of post is not related to the success of the endodontic treatment. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - July 7, 2021 Category: Dentistry Source Type: research

Development of a one-item version of the Orofacial Esthetic Scale
ConclusionThe OES item 8 can be used for the one-item OES (OES-1). It is a psychometrically sound instrument for measuring orofacial appearance.Clinical relevanceDue to its easy application and sufficient psychometric properties, the OES-1 can be used effectively as an alternative to longer OES instruments in all areas of dental practice and research. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - July 6, 2021 Category: Dentistry Source Type: research

Association of temporomandibular disorder-related pain with severe headaches —a Bayesian view
ConclusionThese results indicate that diverse mechanisms may exist behind the associations of TMD-related painful conditions with different types of severe headaches.Clinical relevanceTMD-related pain is a frequent comorbidity of severe primary headaches. Therapy of severe primary headaches may thus benefit significantly with the incorporation of a multi-disciplinary clinical team. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - July 5, 2021 Category: Dentistry Source Type: research

Modified coronally advanced tunnel technique with enamel matrix derivative in addition to subepithelial connective tissue graft compared with connective tissue graft alone for the treatment of multiple gingival recessions: prognostic parameters for clinical treatment outcomes
ConclusionsBased on logistic regression, EMD application improved postoperative ARC, CRC and RES; baseline AERSA predicted 12-month ARC, CRC, and GT gain, whereas baseline GT was a predictor of achieving CRC and perfect RES.Clinical relevanceAdditional use of EMD, lower baseline AERSA, and greater baseline GT significantly increase the odds of obtaining better outcomes 12  months after MCAT + SCTG technique. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - July 4, 2021 Category: Dentistry Source Type: research

P-Cadherin and WNT5A expression in assessment of lymph node metastasis in oral squamous cell carcinoma
The objectives of the study were to assess the biological behaviour of OSCC by correlating the expression levels of P-Cadherin and WNT5A immunohistochemically.MethodsA total of 60 selected OSCCs cases (lymph node metastasis n  = 30, non-metastatic n = 30) and 10 normal healthy controls were quantitatively and qualitatively analysed by immunohistochemistry for P-Cadherin and WNT5A. A survival analysis was also performed.ResultsThe expression levels of P-Cadherin and WNT5A in OSCC groups were statistically significant between metastatic and non-metastatic groups (p  
Source: Clinical Oral Investigations - July 3, 2021 Category: Dentistry Source Type: research

Deep learning for categorization of endodontic lesion based on radiographic periapical index scoring system
ConclusionThe CNN model trained on a limited amount of IOPAR data showed potential for PAI scoring of the periapical lesion on digital IOPAR.Clinical relevanceAn automated system for PAI scoring is developed that would potentially benefit clinician and researchers. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - July 2, 2021 Category: Dentistry Source Type: research

Evaluation of diode laser versus topical corticosteroid in management of Behcet ’s disease-associated oral ulcers: a randomized clinical trial
ConclusionsDiode laser is efficient safe treatment modality for management of BD-associated oral ulcers. Diode laser was more efficient than triamcinolone acetonide in controlling pain and reducing oral ulcer activity.Clinical relevanceLaser therapy is efficient safe modality that could spare BD patient from adding a new medication to their long list, being just one visit compared to other regular daily regimen medications.Trial registration: ClinicalTrials.gov registration number: NCT03771768 (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - July 2, 2021 Category: Dentistry Source Type: research

Caries status of first-born child is a predictor for caries experience in younger siblings
ConclusionCaries could be shown to be family-dependent. Younger siblings had a more than three-fold higher risk for caries if the first-born child already had carious lesions.Clinical relevanceBased on these results, the caries status of the first-born child could be used as a potential indicator to detect vulnerable families and to initiate targeted preventive measures. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - July 1, 2021 Category: Dentistry Source Type: research

The relationship between periodontal status and hyperglycemia after kidney transplantation
ConclusionThe findings suggest that periodontitis may be related to increase of hyperglycemia and FBG levels in KTx patients.Clinical relevancePeriodontitis severity and cardiovascular disease were positively associated with FBG levels in KTx patients. Clinicians and patients should be aware of the potential benefit of periodontal care for better glycemic control management. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - July 1, 2021 Category: Dentistry Source Type: research

Oral transmucosal absorption of iodine after intraoral preparation with povidone-iodine prior to oral surgeries: a randomized controlled study in 12 male patients
Conclusion(s)Oral transmucosal absorption of iodine is observed when povidone-iodine is used for intraoral preparation in healthy male adults, though the free thyroxine in blood is not affected accordingly.Clinical relevancePovidone-iodine is commonly used as an antiseptic in oral surgery and dental clinics. Based on our findings that iodine levels in blood and urine may elevate significantly after intraoral preparation with povidone-iodine prior to oral surgeries, care must be taken for individuals when excess iodine intakes can endanger the safety of the patient.Registration informationName of the trial registry: The Chi...
Source: Clinical Oral Investigations - July 1, 2021 Category: Dentistry Source Type: research

Periodontitis severity in obstructive sleep apnea patients
AbstractObjectivesThis cross-sectional study investigated the stages of periodontitis in obstructive sleep apnea (OSA) patients and risk factors associated with periodontitis severity among them.Materials and methodsA total of 194 patients underwent a polysomnography/polygraphy and were referred to periodontal examination. According to apnea –hypopnea index (AHI), patients were classified as mild OSA (AHI 
Source: Clinical Oral Investigations - June 30, 2021 Category: Dentistry Source Type: research

Cyclic tensile strain affects the response of human periodontal ligament stromal cells to tumor necrosis factor- α
ConclusionsOur findings show that mechanical force differentially regulates TNF- α-induced expression of inflammatory mediators and adhesion molecules at the early stage of force application. The effect of cyclic tensile strain is complex and could be either anti-inflammatory or pro-inflammatory depending on the type of pro-inflammatory mediators and force magnitude.Clinical relevanceOrthodontic forces regulate the inflammatory mediators of periodontitis. The underlying mechanism may have significant implications for future strategies of combined periodontal and orthodontic treatment. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - June 29, 2021 Category: Dentistry Source Type: research

Platform technologies for regenerative endodontics from multifunctional biomaterials to tooth-on-a-chip strategies
ConclusionsCurrent clinical treatments lack functional and predictable pulp regeneration and are more focused on the treatment of the consequences of pulp exposure, rather than the restoration of healthy dental pulp.Clinical relevanceClinically, there is great demand for bioinspired biomaterial strategies that are safe, efficacious, and easy to use, and clinicians are eager for their clinical translation. In particular, we place emphasis on strategies that combine favorable angiogenesis, mineralization, and functional tissue formation, while limiting immune reaction, risk of microbial infection, and pulp necrosis. (Source:...
Source: Clinical Oral Investigations - June 28, 2021 Category: Dentistry Source Type: research

The effect of obesity on periodontitis progression: the 10-year retrospective cohort study
ConclusionsDespite the higher incidence of disease progression in the obese, obesity is not an independent risk factor for periodontitis progression.Clinical relevanceObesity and periodontitis progression share many common risk factors. Using the obesity as a preliminary screening for periodontitis progression may be an alternative prevention protocol. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - June 28, 2021 Category: Dentistry Source Type: research

Correction to: Tooth loss and adiposity: possible role of carnitine transporter (OCTN1/2) polymorphisms in women but not in men
The online version of the original article can be found athttps://doi.org/10.1007/s00784-020 –03594-w (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - June 28, 2021 Category: Dentistry Source Type: research

The impact of the COVID-19 pandemic on the dental-maxillofacial emergency service of a German university hospital in the year 2020
In this study, the impact of the COVID-19-pandemic on a dental and CMFS emergency services in Germany in 2020 was first tim e investigated and correlated with governmental restriction measures in public life.Materials and methodsEpidemiological data of a German University Hospital were analysed from a total of 8386 patients in 2019 and 2020. Parameters included information on demographics, time, weekday and reason for presentation, as well as diagnosis and therapy performed. Data from 2020 were compared with those from 2019, taking into account the nationwide periods of public life restrictions.ResultsIn 2020, 22% fewer pa...
Source: Clinical Oral Investigations - June 26, 2021 Category: Dentistry Source Type: research

Diagnosis of interproximal caries lesions with deep convolutional neural network in digital bitewing radiographs
ConclusionsThe proposed CNN model showed good performance with high accuracy scores demonstrating that it could be used in the diagnosis of caries lesions in bitewing radiographs.Clinical significanceCorrect diagnosis of dental caries is essential for a correct treatment procedure. CNNs can assist dentists in diagnosing approximal caries lesions in bitewing radiographs. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - June 25, 2021 Category: Dentistry Source Type: research