Effect of bleaching gel volume on color change and postoperative sensitivity: a randomized clinical study
This study thus aimed to evaluate the influence of bleaching gel volume on chromatic alteration and postoperative sensitivity.MethodologyThirty patients were selected and allocated into three groups; the lower canines were analyzed according to the volume of gel used: GI-0.025  mL, GII-0.05 mL, and GIII-0.10 mL. Chromatic alteration analysis was performed using a portable digital spectrophotometer by calculating the ΔE, ΔE00, ΔL*, Δa*, and Δb* values and the whiteness index (WID). Spontaneous sensitivity was assessed using a questionnaire, and sensitivity was stimulated by therm...
Source: Clinical Oral Investigations - October 16, 2021 Category: Dentistry Source Type: research

Effect and longevity of botulinum toxin in the treatment of gummy smile: a meta-analysis and meta-regression
AbstractObjectiveThe aim of this systematic review is to synthesize the evidence on the effectiveness and longevity of the botulinum toxin in the treatment of individuals with excessive gingival exposure.MethodsThe search was adapted to six electronic databases and gray literature. The risk of bias was assessed using the Cochrane Risk of Bias Assessment Tool for Non-Randomized and Randomized Studies of Interventions. Meta-analyses and meta-regression were performed using random effects models.ResultsA total of 5247 articles were collected during the final search in the database, resulting in 17 articles included. There was...
Source: Clinical Oral Investigations - October 15, 2021 Category: Dentistry Source Type: research

Oral health-related quality of life and satisfaction in edentulous patients rehabilitated with implant-supported full dentures all-on-four concept: a systematic review
ConclusionOHRQoL and satisfaction in patients whose rehabilitation was based on the all-on-four concept were high. However, the current evidence is still limited by the quality of the available studies, making long-term randomized studies necessary to establish the real effectiveness of this surgical-prosthetic approach.Clinical relevanceCarefully analyze the aspects related to satisfaction and oral health-related quality of life of rehabilitated patients with implant-supported total prostheses made according to the all-on-four concept, aiming to achieve success through procedures with greater predictability and less compl...
Source: Clinical Oral Investigations - October 13, 2021 Category: Dentistry Source Type: research

Treatment of intrabony periodontal defects in controlled diabetic patients with an enamel matrix derivative: a split-mouth randomized clinical trial
AbstractObjectiveThis split-mouth randomized controlled trial aimed to evaluate the effect of enamel matrix derivative (EMD) associated with a simplified papilla preservation flap (SPPF) compared to SPPF alone in the surgical treatment of intrabony defects (ID) in type 2 diabetic mellitus (T2DM) patients.Material and methodsThirteen patients with controlled T2DM presenting with ID in at least two quadrants were included. In each patient, the test site (TS) was treated with SPPF plus EMD, whereas the control site (CS) was treated only with SPPF. Prior to surgery and at 6  months after intervention, the following parame...
Source: Clinical Oral Investigations - October 13, 2021 Category: Dentistry Source Type: research

Fatigue behavior and stress distribution of molars restored with MOD inlays with and without deep margin elevation
This study evaluated the effect of deep margin elevation (DME) and restorative materials (leucite-reinforced glass –ceramics [C] vs. indirect resin composite [R]) on the fatigue behavior and stress distribution of maxillary molars with 2-mm deep proximal margins restored with MOD inlay.MethodsFifty-two extracted human third molars were randomly assigned into four groups (n = 13): C; DME + C; R; and DME + R. Inlays were fabricated in CAD-CAM and bonded to all teeth. The fatigue behavior was assessed with the stepwise stress test (10,000 cycles/step; step = 50&nbs...
Source: Clinical Oral Investigations - October 13, 2021 Category: Dentistry Source Type: research

Effects of low-level light therapy on dentin hypersensitivity: a systematic review and meta-analysis
ConclusionsThis systematic review shows that LLLT has positive immediate, interim, and persistent DH-treatment efficacies compared with placebo. No superior treatment effects of LLLT were observed except fluoride agent use. Further studies are warranted —RCTs with low risk of bias, consistent technical settings, comprehensive assessments, and long follow-up periods.Clinical relevanceThis systematic review bridges a critical research gap by analysing clinical evidence in the DH-alleviating efficacy of LLLT in comparison with placebo and other in-office desensitising strategies. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - October 13, 2021 Category: Dentistry Source Type: research

Diagnostic validity of early proximal caries detection using near-infrared imaging technology on 3D range data of posterior teeth
ConclusionsNIRR achieved diagnostic results comparable to BWR. Trilateral NIRR assessments overestimated presence of proximal caries, revealing stronger sensitivity for initial caries detection than BWR.Clinical relevanceNIRR provided valid complement to BWR as diagnostic instrument. Investigation from multiple angles did not substantially improve proximal caries detection with NIRR. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - October 12, 2021 Category: Dentistry Source Type: research

Efficacy of the dual-action GA-KR12 peptide for remineralising initial enamel caries: an in vitro study
AbstractObjectiveTo investigate the antibiofilm and remineralising effects of the dual-action peptide GA-KR12 on artificial enamel caries.Materials and methodsEnamel blocks with artificial caries were treated with sterilised deionised water as control or GA-KR12. The blocks underwent biochemical cycling withStreptococcus mutans for 3  weeks. The architecture, viability, and growth kinetics of the biofilm were determined, respectively, by scanning electron microscopy (SEM), confocal laser scanning microscopy, and quantitative (culture colony-forming units, CFUs). The mineral loss, calcium-to-phosphorus ratio, surface m...
Source: Clinical Oral Investigations - October 12, 2021 Category: Dentistry Source Type: research

Diagnostic accuracy of in vivo early tumor imaging from probe-based confocal laser endomicroscopy versus histologic examination in head and neck squamous cell carcinoma
ConclusionFinal sensitivity scores were reasonable but final specificity scores were low. pCLE zones used to calculate specificity were acquired in areas of tumor margins, and the poor quality of the images acquired in these areas explains the final low specificity scores.Clinical relevancePractical adjustments and technical training are needed to analyze head and neck lesions in various anatomical sites in real-time by pCLE. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - October 12, 2021 Category: Dentistry Source Type: research

A composite oral hygiene score and the risk of oral cancer and its subtypes: a large-scale propensity score-based study
ConclusionThis study establishes a composite oral hygiene score and provides supportive evidence of poor oral hygiene associated with a higher risk of oral cancer, particularly in the gingival and buccal mucosa sites and in the squamous cell carcinoma.Clinical relevance.The data highlights the importance of improving poor oral hygiene habits, which has public health implications for the prevention of oral cancer. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - October 10, 2021 Category: Dentistry Source Type: research

Clinical outcome of bonded partial indirect posterior restorations on vital and non-vital teeth: a systematic review and meta-analysis
ConclusionsWithin the limits of this study, these findings suggest that the risk of failure of indirect partial adhesive restorations on endodontically treated teeth is higher than on vital teeth.Clinical relevanceThe use of partial adhesive restorations on vital and endodontically treated teeth showed different long-term clinical outcomes. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - October 10, 2021 Category: Dentistry Source Type: research

Outcomes of treatment and monitoring of posterior teeth with cracks: three-year results from the National Dental Practice-Based Research Network
ConclusionsIn this large 3-year practice-based study conducted across the USA, the survival rate of posterior teeth with a visible crack exceeded 85%.Clinical relevanceDentists can effectively evaluate patient-, tooth-, and crack-level characteristics to determine which teeth with cracks warrant treatment and which only warrant monitoring. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - October 9, 2021 Category: Dentistry Source Type: research

Frequency of the necessity of dentoalveolar surgery or conservative treatment in patients before kidney transplantation depending on the duration of dialysis and causative nephrological disease
ConclusionsOperative and conservative treatment is essential to optimize subsequent kidney transplantation. The greatest necessity could be detected for patients in the second and third years of dialysis.Clinical relevanceOral health addressing surgical and conservative treatment need depends on the duration of dialysis in patients with a chronic kidney end-stage disease. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - October 8, 2021 Category: Dentistry Source Type: research

Local application of hyaluronic acid in conjunction with free gingival graft: a randomized clinical trial
ConclusionsTopical application of HA may exhibit significant improvement of postoperative pain and no significant difference in graft dimensions and patients ’ satisfaction.Clinical relevanceTopical application of HA is recommended as a dressing material in FGG surgeries to reduce postoperative pain and accelerate healing. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - October 8, 2021 Category: Dentistry Source Type: research

STAndard Reporting of CAries Detection and Diagnostic Studies (STARCARDDS)
ConclusionFollowing STARCARDDS (STAndard Reporting of CAries Detection and Diagnostic Studies) is expected to result in complete reporting of study design and methodology in future caries diagnosis and detection experiments both in vivo and in vitro, thus allowing for better comparability of studies and higher quality of systematic reviews.Clinical relevanceStandardization of caries diagnostic studies leads to a better comparability among future studies, both in vivo and in vitro. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - October 8, 2021 Category: Dentistry Source Type: research

Current strategies for conservative endodontic access cavity preparation techniques —systematic review, meta-analysis, and decision-making protocol
AbstractObjectivesTo assess related studies and discuss the clinical implications of endodontic access cavity (AC) designs.Materials and methodsA systematic review of studies comparing the fracture resistance and/or endodontic outcomes between different AC designs was conducted in two electronic search databases (PubMed and Web of Science) following the PRISMA guidelines. Study selection, data extraction, and quality assessment were performed. Meta-analyses were undertaken for fracture resistance and root canal detection, with the level of significance set at 0.05 (P = 0.05).ResultsA total of 33 articles were...
Source: Clinical Oral Investigations - October 8, 2021 Category: Dentistry Source Type: research

Clinical study showing a lower abundance of Neisseria in the oral microbiome aligns with low birth weight pregnancy outcomes
ConclusionLower levels ofNeisseria align with preterm low birth weight in pregnant women, whereas a higher abundance ofTreponema, Porphyromonas,Fretibacterium, andFilifactor and a lower abundance ofStreptococcus may contribute to periodontal disease during pregnancy.Clinical relevanceThe oral commensalNeisseria have potential in the prediction of PLBW. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - October 8, 2021 Category: Dentistry Source Type: research

Ridge preservation in maxillary molar extraction sites with severe periodontitis: a prospective observational clinical trial
AbstractObjectivesTo assess alveolar bone changes and treatment modality alterations after ridge preservation on maxillary molar extraction sockets with severe periodontitis, compared to natural healing.Material and methodsThirty-six maxillary infected-molar teeth either receiving ridge preservation (RG group) or undergoing natural healing (NT group) were investigated. Cone-beam computed tomography (CBCT) scanning was performed immediately after surgery (the baseline) and repeated 6 months later to measure the linear and volumetric changes of the sockets.ResultsBased on radiographic measurements, alveolar bone width decrea...
Source: Clinical Oral Investigations - October 8, 2021 Category: Dentistry Source Type: research

The association between coffee consumption and periodontitis: a cross-sectional study of a northern German population
Conclusionand clinical relevance.In this cross-sectional study of a northern German population, strong coffee consumption was significantly associated with periodontitis. Influence of changes in coffee consumption on periodontal disease etiology/progression should be investigated in future prospective study designs, in order to identify strong coffee consumption as a potential risk factor of periodontitis. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - October 7, 2021 Category: Dentistry Source Type: research

Cross-linked hyaluronic acid slows down collagen membrane resorption in diabetic rats through reducing the number of macrophages
AbstractObjectivesWe previously showed that accelerated degradation of collagen membranes (CMs) in diabetic rats is associated with increased infiltration of macrophages and blood vessels. Since pre-implantation immersion of CMs in cross-linked high molecular weight hyaluronic acid (CLHA) delays membrane degradation, we evaluated here its effect on the number of macrophages and endothelial cells (ECs) within the CM as a possible mechanism for inhibition of CM resorption.Materials and methodsDiabetes was induced with streptozotocin in 16 rats, while 16 healthy rats served as control. CM discs were labeled with biotin, soake...
Source: Clinical Oral Investigations - October 4, 2021 Category: Dentistry Source Type: research

Effect of surface treatments and flash-free adhesive on the shear bond strength of ceramic orthodontic brackets to CAD/CAM provisional materials
AbstractObjectivesTo evaluate the effect of surface treatments and flash-free adhesive on the shear bond strength of ceramic orthodontic brackets bonded to materials used for the fabrication of CAD/CAM provisional crowns.Materials and methodsSpecimens (n = 160) from each provisional material (CAD-Temp and C-Temp) were categorized into four groups according to the surface treatment methods: C (no surface treatment), HP (37% H3PO4), DB (mechanical roughening by diamond bur), and SB (mechanical roughening by blasting). Maxillary central incisor ceramic brackets (Clarity ™ Advanced ceramic brackets, 3 ...
Source: Clinical Oral Investigations - October 4, 2021 Category: Dentistry Source Type: research

Stage II and stage III periodontitis clinical burdens of HIV-1 undergoing antiretroviral therapy
AbstractObjectivesThe aim of this retrospective cross-sectional study was to estimate the association of HIV-1 infection under highly active antiretroviral treatment (HAART) on the clinical parameters of periodontitis.Materials and methodsA total of 205 patients were divided in two groups: 74 HIV  + and 131 HIV − . Periodontal probing depth (PPD), clinical attachment loss (CAL), bleeding on probing (BOP), and visible supragingival biofilm (VSB) were recorded. The association of HIV-1 infection with the presence of at least 3 sites with PPD ≥ 5 mm and/or CAL &ge...
Source: Clinical Oral Investigations - October 3, 2021 Category: Dentistry Source Type: research

The impact of different dental restorations on detection of proximal caries by cone beam computed tomography
ConclusionsCBCT scans performed for tasks other than caries detection should be assessed for proximal caries in absence of any restorations as well as in presence of composite, RMGIC fillings, and lithium disilicate crowns. However, CBCT should not be used for proximal caries detection in teeth adjacent to amalgam and teeth surfaces mesial to zirconia crowns.Clinical significanceIt is important to investigate the influence of artifacts produced by various restorations on CBCT-based caries detection to optimize CBCT benefits, caries diagnosis and avoid unnecessary treatment of sound surfaces. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - October 3, 2021 Category: Dentistry Source Type: research

Comparison of two different digital occlusal analysis methods
ConclusionsWhile T-Scan was found sensitive even in the diagnosis of light contacts, the CEREC Omnicam was found sensitive only in the diagnosis of tight contacts.Clinical relevanceAlthough both T-Scan and CEREC Omnicam are effective in occlusal analysis, T-Scan ’s sensitivity was found to be higher.Trial registrationClinicalTrials.gov identifier: NCT04798729 (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - October 1, 2021 Category: Dentistry Source Type: research

Non-surgical treatment as an alternative for the management of central giant cell granuloma: a systematic review
ConclusionDespite the side effects presented and the need for additional surgery in some patients, in general, all non-surgical treatments could provide positive results as an alternative for the management of CGCG, especially with regard to reducing the size of the lesion.Clinical relevanceCGCG is a benign bone lesion that mainly affects young individuals. Although the most common therapy is surgery, its contraindication in some patients, the large extension, and high recurrence rate of the aggressive variant have led the search for non-surgical therapies. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - October 1, 2021 Category: Dentistry Source Type: research

Effects of charcoal-based whitening toothpastes on human enamel in terms of color, surface roughness, and microhardness: an in vitro study
AbstractObjectiveCharcoal based oral care products have gained popularity in the last few years. The aim of this in vitro study was to compare the effects of different charcoal based whitening toothpastes on color, surface roughness and microhardness of human enamel.Materials and methodsForty-eight specimens obtained from human permanent upper incisor teeth were randomly divided into 4 groups(n=12):Group-1:Colgate Total 12(CT); Group-2:Body Kingdom(BK); Group-3:Black is White(BW), Group-4:Colgate optic white(COW). Following 4 days cycle of darkening(2-min chlorhexidine and 60-min black tea per day), a 12- week brushing(twi...
Source: Clinical Oral Investigations - September 15, 2021 Category: Dentistry Source Type: research

Lip repositioning surgery for gummy smile: 6-month clinical and radiographic lip dimensional changes
AbstractObjectivesThe present case series aimed to examine lip repositioning surgery (LRS) outcomes related to changes in external and internal upper lip (UL) dimensions, utilizing both conventional clinical and novel radiographic approaches.Materials and methodsPatients (n = 13) diagnosed with hypermobile UL (>8-mm mobility during smile) and excessive gingival display ( ≥4-mm) were included and assessed at baseline and 6 months postoperatively. Clinical parameters at rest included total lip and internal lip length (vestibular depth). At maximum smile included total lip, philtrum (ergotrid), and vermilion lengths. Ce...
Source: Clinical Oral Investigations - September 15, 2021 Category: Dentistry Source Type: research

Systemic circulating inflammatory burden and periodontitis in adolescents
AbstractObjectivesTo analyze the association between systemic inflammatory burden of cardiovascular disease (CVD) risk and periodontitis in adolescents, including mediating pathways triggered by their common risk factors.Materials and methodsUsing a population-based sample study (n = 405) of Brazilian adolescents (17 –18 years old), direct and mediation pathways triggered by “Socioeconomic Status,” “Adiposity,” Smoking, and “Blood Pressure” were modelled for the association between the “Systemic Circulating Inflammatory Burden of CVD Risk” (IL-1β, IL-6, IL-8, TNF-&...
Source: Clinical Oral Investigations - September 15, 2021 Category: Dentistry Source Type: research

Dynamic contrast-enhanced magnetic resonance imaging for monitoring neovascularization during bone regeneration —a randomized in vivo study in rabbits
ConclusionsThese results support the hypothesis that DCE-MRI can be used to monitor neovascularization but contradict the premise that it could predict bone regeneration as well. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - September 15, 2021 Category: Dentistry Source Type: research

The resin-matrix cement layer thickness resultant from the intracanal fitting of teeth root canal posts: an integrative review
ConclusionsIn fact, the layer thickness of resin-matrix cements depends on the fitting of endodontic posts to tooth root canals. An increase of resin cement  thickness causes the appearance of defects like pores, micro-cracks, and micro-gaps that can induce stress concentration and fractures at interfaces.Clinical relevanceThe fitting of the endodontic  post into the teeth root canal determine the layer thickness of the resin-matrix cement to establish an adequate retention. However, the increase in the thickness of the resin-matrix cement layer can lead to a high number of defects like pores or cr...
Source: Clinical Oral Investigations - September 15, 2021 Category: Dentistry Source Type: research

Retrospective study on the effectiveness of a prevention strategy in a dental hospital during the COVID-19 pandemic
ConclusionDuring the study period in 2020, the total number of hospital visits dramatically reduced but emergency visits significantly increased. The prevention strategy implemented successfully prevented SARS-CoV-2 infection spread among healthcare workers in a dental hospital.Clinical relevanceThe prevention strategy indicated patient triage and how to adopt preventive measures for controlling SARS-CoV-2 spread among healthcare workers. These data can be used as a reference for other sectors suffering from the COVID-19 pandemic. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - September 15, 2021 Category: Dentistry Source Type: research

Metabolic activity of hydro-carbon-oxo-borate on a multispecies subgingival periodontal biofilm: a short communication
This study evaluated the metabolic activity of hydro-carbon-oxo-borate complex (HCOBc) on a multispecies subgingival biofilm as well as its effects on cytotoxicity.Materials and methodsThe subgingival biofilm with 32 species related to periodontitis was formed in the Calgary Biofilm Device (CBD) for 7 days. Two different therapeutic schemes were adopted: (1) treatment with HCOBc, 0.12% chlorhexidine (CHX), and negative control group (without treatment) from day 3 until day 6, two times a day for 1 min each time, totaling 8 treatments and (2) a 24-h treatment on a biofilm grown for 6 days. After 7 days of formation, biofilm...
Source: Clinical Oral Investigations - September 15, 2021 Category: Dentistry Source Type: research

Oral health-related quality of life in patients with heart failure and left ventricular assist devices —results of a cross-sectional study
AbstractObjectivesThe aim of this cross-sectional study was to compare oral health-related quality of life (OHRQoL) of patients with left ventricular assist device (LVAD) and heart failure (HF).Material and methodsSeventy-four patients with LVAD were recruited from University Department for Cardiac Surgery, Leipzig Heart Center, Germany. A group of 72 patients with HF was composed by matching (age, gender, smoking). The German short form of oral health impact profile (OHIP G14) was applied. Health-related quality of life (HRQoL) was measured by short form 36 survey (SF-36). Dental conditions (decayed-, missing- and filled-...
Source: Clinical Oral Investigations - September 15, 2021 Category: Dentistry Source Type: research

Surgical and non-surgical debridement for the treatment of peri-implantitis: a two-center 12-month randomized trial
ConclusionsSurgical and non-surgical debridement for the treatment of peri-implantitis present similar clinical outcomes. Bone levels were better improved in ST than NST for sites with higher initial bone loss.Clinical relevanceThe treatment of peri-implantitis is still a challenge in clinical practice, since less than half of affected implants achieve health after surgical or non-surgical debridement. Considering the lack of clinically relevant differences between these two treatments, non-surgical debridement should be considered the first therapeutic choice for peri-implantitis, mainly mild to moderate cases. (Source: C...
Source: Clinical Oral Investigations - September 15, 2021 Category: Dentistry Source Type: research

Correction to: Class II resin composite restorations —tunnel vs. box-only in vitro and in vivo
(Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - September 15, 2021 Category: Dentistry Source Type: research

Clinical study comparing the accuracy of interocclusal records, digitally obtained by three different devices
ConclusionResults suggest greater reliability to record occlusal contacts with the intraoral scanner.Clinical relevanceIntraoral scanners seem to be reliable in registering intermaxillary occlusal contacts when compared with the current gold standard. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - September 14, 2021 Category: Dentistry Source Type: research

Phosphorylated PAMAM dendrimers: an analog of dentin non-collagenous proteins, enhancing the osteo/odontogenic differentiation of dental pulp stem cells
In this study, phosphorylated PAMAM (P-PAMAM) dendrimers were synthesized based on the idea of mimicking the phosphorylated proteins of dentin non-collagenous proteins (DNCP). Then, proliferation and osteo/odontogenic differentiation effects of P-PAMAM on dental pulp stem cells (DPSCs) were investigated and were compared with DNCP.Materials and methodsP-PAMAM was synthesized via the Mannich-type reaction. DNCP were extracted directly from human dentin with ethylenediaminetetraacetic acid (EDTA) solution. Then, the conditioned medium of P-PAMAM and DNCP were prepared respectively and applied to DPSCs. Proliferation of P-PAM...
Source: Clinical Oral Investigations - September 13, 2021 Category: Dentistry Source Type: research

Three-dimensional volumetric evaluation of dental pulp cavity/tooth ratio in anterior open bite malocclusion using cone beam computed tomography
ConclusionAnterior open bite malocclusion might lead to an increase of the pulp cavity volume and decrease of the tooth volume due to occlusal hypofunction.Clinical relevanceOrthodontic force should be carefully determined in anterior open bite patient due to the greater root canal volume and lesser root volume. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - September 11, 2021 Category: Dentistry Source Type: research

Two-year randomized clinical trial of different restorative techniques in non-carious cervical lesions and MMP activity in gingival crevicular fluid
ConclusionsAll restorative techniques performed similarly in NCCLs after 2  years with initial marginal defect alterations. MMP-2 reestablished its initial levels after 2 years, and MMP-9 had few alterations over time in crevicular fluid.Clinical relevanceThe different restorative techniques are equally successful in NCCLs after 2  years of clinical functioning and have similar effects on MMPs present in crevicular fluid. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - September 10, 2021 Category: Dentistry Source Type: research

Enamel erosion control by strontium-containing TiO2- and/or MgO-doped phosphate bioactive glass
ConclusionAll bioactive materials protected the enamel against erosion. However, strontium-containing phosphate bioactive glasses showed lower enamel loss, and the presence of Mg in these bioactive glasses provided a greater protective effect.Clinical relevanceExperimental strontium-containing phosphate bioactive glasses are effective in controlling enamel erosion. The results obtained in this study will guide the development of new dental products. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - September 10, 2021 Category: Dentistry Source Type: research

Effect of micro-osteoperforations on the gene expression profile of the periodontal ligament of orthodontically moved human teeth
This study aimed to evaluate the effect of micro-osteoperforations (MOPs) on the gene expression profile of the periodontal ligament (PDL) of orthodontically moved teeth.Materials and methodsFifteen participants were randomly assigned into two groups: tooth movement only (Tr1,n = 7) and tooth movement supplemented with MOPs (Tr2,n = 8). In each subject, orthodontic tooth movement (OTM) was performed on premolar in one side, while no force was applied on contralateral premolar (Unt,n = 15). Seven days after loading, premolars were extracted for orthodontic reasons. RNA extraction fr...
Source: Clinical Oral Investigations - September 9, 2021 Category: Dentistry Source Type: research

Prevalence of red and orange microbial complexes in endodontic-periodontal lesions: a systematic review and meta-analysis
ConclusionsThere is a similarity between the microbiome of root canal and periodontal pockets, with prevalence of the three microorganisms of the orange complex. Two microorganisms from the red complex were prevalent only in periodontal pockets.Clinical relevanceThe prevalence of specific microorganisms in endodontic-periodontal lesion is important to understand the microbiological profile of the patients involved and to correlate it with possible clinical and repair conditions of this pathology. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - September 8, 2021 Category: Dentistry Source Type: research

Intraoral scanner-based monitoring of tooth wear in young adults: 12-month results
AbstractObjectivesTo investigate tooth wear in young adults, intraoral scanning was used for digital monitoring of the mandibular first molar over 12  months. A possible influence of aetiological factors obtained by a questionnaire on tooth wear was investigated.Materials and methodsA total of 109 participants (mean age at the start of the study: 21.0  ± 2.2 years) were included in this clinical study. At baseline (T0), an intraoral scan (Trios 3, 3Shape) of the study tooth (FDI # 36 or #46) was conducted. After a mean observation period of 373 ± 19 days, a second in...
Source: Clinical Oral Investigations - September 8, 2021 Category: Dentistry Source Type: research

Assessment of bone metabolism biomarkers in serum and saliva of cirrhotic patients
ConclusionRANKL, OPG, IL-1 β, IL-6 and TNF-α are expressed differently in serum and saliva and the concentration of these biomarkers is not related to MCI.Clinical relevanceThis study contributes to the study of the mechanisms of osteoporosis in cirrhotic individuals. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - September 7, 2021 Category: Dentistry Source Type: research

Early failures when using three different adhesively retained core build-up materials —a randomized controlled trial
AbstractObjectivesTo compare the failure rates for three different adhesively retained core build-up composites up to the incorporation of a permanent fixed dental prosthesis (FDP), and to identify potential failure risk factors.Material and methodsA randomized controlled trial of 300 participants in need of a core build-up to restore a vital abutment tooth before prosthetic treatment was conducted. Participants were assigned by stratified block randomization to one of three study groups: Rebilda DC (RDC), Clearfil DC Core (CDC), or Multicore Flow (MF). Test teeth were prepared by use of the respective manufacturer ’...
Source: Clinical Oral Investigations - September 7, 2021 Category: Dentistry Source Type: research

Factors associated with edentulous patients ’ willingness about implant-supported complete denture: a multivariate analysis
ConclusionPrevious experience with mandibular complete dentures and dissatisfaction about retention influence the willingness about mandibular implant-supported overdenture.Clinical relevanceMany factors are associated with rehabilitation preferences for edentulous patients and mandibular implant-supported complete denture is one of the available alternatives. Therefore, this study has demonstrated the factors influencing the decision to replace a mandibular conventional complete denture by dental implant treatment based on patient ’s outcomes. Such finding may be considered as a relevant aspect towards shared decisi...
Source: Clinical Oral Investigations - September 7, 2021 Category: Dentistry Source Type: research

The role of surgical flap design (minimally invasive flap vs. extended flap with papilla preservation) on the healing of intrabony defects treated with an enamel matrix derivative: a 12-month two-center randomized controlled clinical trial
AbstractObjectivesMinimally invasive flap designs have been introduced to enhance blood clot stability and support wound healing. Limited data appear to suggest, that in intrabony defects, better clinical outcomes can be achieved by means of minimally invasive flap compared to more extended flaps. The aim of this study was to evaluate the healing of intrabony defects treated with either minimally invasive surgical flaps or with modified or simplified papilla preservation techniques in conjunction with the application of an enamel matrix derivative (EMD).Materials and methodsForty-seven subjects were randomly assigned to ei...
Source: Clinical Oral Investigations - September 7, 2021 Category: Dentistry Source Type: research

Quantitative sensory testing in patients with the muscle pain subtype of temporomandibular disorder: a systemic review and meta-analysis
ConclusionsThe study results suggest that the pain processing of deep tissues is likely sensitized in mTMD and calls for more QST studies with standard procedures to reduce inter-study heterogeneity.Clinical relevanceThe major findings of this meta-analysis support using PPT to examine the pain processing in patients with mTMD in clinical scenario. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - September 6, 2021 Category: Dentistry Source Type: research

The effect of changing apical foramen diameter on regenerative potential of mature teeth with necrotic pulp and apical periodontitis
ConclusionIncreasing the apical size diameter was associated with less inflammatory cell count, less percentage of bone resorption, more tissue ingrowth, and more percentage of new hard tissue formation inside root canal. The minimum apical diameter that should be enlarged for RET is 0.4  mm.Clinical relevanceRET could be used as an alternative procedure to RCT for the treatment of mature teeth with necrotic pulp and apical periodontitis. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - September 4, 2021 Category: Dentistry Source Type: research

Systematic review and meta-analysis of diagnostic studies of proximal surface caries
ConclusionThe number of diagnostic studies with low/moderate RoB was found to be low and indicates a need for high-quality, well-designed caries diagnostic studies.Clinical relevanceBWR and LF showed good diagnostic performance on proximal surfaces. However, because of the low number of includable clinical studies, these data should be interpreted with caution. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - September 4, 2021 Category: Dentistry Source Type: research