Salivary MRP-8/14 and the presence of periodontitis-associated bacteria in children with bonded maxillary expansion treatment
ConclusionTherapy with bonded maxillary results in higher MRP-8/14 levels and increased prevalence of some periodontitis-associated bacteria, namelyT. forsythia,T. denticola, andE. corrodens. The results suggest the detection of salivary MRP-8/14 levels may be a potential tool to reflect the oral health status in children with fixed orthodontic treatment.Clinical relevanceOur data suggest that the treatment with bonded maxillary expander might influence the oral health status and should be accompanied by the careful control of the oral health during the therapy. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - December 3, 2020 Category: Dentistry Source Type: research

A retrospective analysis of autotransplanted teeth including an evaluation of a novel surgical technique
ConclusionAutotransplanted teeth yielded a satisfying midterm survival rate regardless of their stage of development. An additional, extraoral root-end resection of mature transplants may lead to rates of revascularization and postoperative pulp canal obliteration higher than the data reported on unmodified mature transplants.Clinical relevanceExtraoral root-end resection of mature teeth shows promising outcomes for transplants especially with a single root canal and uncomplicated root morphology. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - December 2, 2020 Category: Dentistry Source Type: research

Local delivery therapies as adjuvants to non-surgical periodontal treatment of periodontitis grade C: a systematic review
ConclusionAlthough 1.2 mg SMV gel (1.2 mg/0.1 ml), 1% ALN gel (10 mg/ml), and 25% MTZ gel (Elyzol) have shown better results, local therapies adjuvant to SRP the data found were limited. Future clinical studies with appreciable methodological quality should be conducted.Clinical relevanceDespite some benefits of local delivery therapy, up to now, it has not been possible to prove the efficacy of local therapy as an adjunct to standard treatment of AgP (periodontitis grade C). (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - November 14, 2020 Category: Dentistry Source Type: research

Physiopathology of nitric oxide in the oral environment and its biotechnological potential for new oral treatments: a literature review
ConclusionsThe understanding of how NO can interfere in oral health maintenance or disease processes can contribute to elucidate the disease development and optimize treatment approaches.Clinical relevanceNO has considerable biotechnological potential and can contribute to improving diagnostics and treating the oral environment. As a biomarker, NO has an important role in the early diagnosis of diseases. Regarding treatments, NO can possibly be used as a regulator of inflammation, anti-biofilm action, replacing antibiotics, inducing apoptosis of cancerous cells, and contributing to the angiogenesis. All these studies are i...
Source: Clinical Oral Investigations - November 14, 2020 Category: Dentistry Source Type: research

Does delayed toothbrushing after the consumption of erosive foodstuffs or beverages decrease erosive tooth wear? A systematic review and meta-analysis
AbstractObjectiveControversy exists regarding the effectiveness of delayed toothbrushing in decreasing erosive tooth wear (ETW). The purpose of this systematic review and meta-analysis was to assess the effects of delayed toothbrushing on ETW.Materials and methodsThis systematic review and meta-analysis was conducted according to the PRISMA statement and registered in PROSPERO (CRD42020200463). PubMed, Embase, and Web of Science databases were systematically searched with no publication year limits. Screening and data extraction were performed independently by two reviewers. In situ and in vitro studies comparing ETW after...
Source: Clinical Oral Investigations - November 14, 2020 Category: Dentistry Source Type: research

Clinical status determines the efficacy of salivary and nasopharyngeal samples for detection of SARS-CoV-2
(Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - November 14, 2020 Category: Dentistry Source Type: research

Correction to: The effectiveness of ultrasound examination to assess the healing process of bone lesions of the jaws: a systematic review
The given names of the authors are swapped with their family names. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - November 14, 2020 Category: Dentistry Source Type: research

Hereditary gingival fibromatosis in children: a systematic review of the literature
AbstractObjectivesHereditary gingival fibromatosis (HGF) is an uncommon, inherited condition with slow and progressive fibrous hyperplasia of the gingiva. Due to its association with mastication, speech, and occlusion problems, early diagnosis is important. We sought to summarize the available data regarding the epidemiology, clinical characteristics, and outcomes of children with HGF (
Source: Clinical Oral Investigations - November 13, 2020 Category: Dentistry Source Type: research

The effect of cetylpyridinium chloride mouthrinse as adjunct to toothbrushing compared to placebo on interproximal plaque and gingival inflammation —a systematic review with meta-analyses
ConclusionsWhen considering interproximal surfaces, CPC is efficacious both in plaque and gingival inflammatory parameters, demonstrating the potential to compensate for the limitations of interproximal plaque control.Clinical relevanceCPC may be a good alternative to compensate interproximal plaque removal, improving interproximal gingivitis (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - November 13, 2020 Category: Dentistry Source Type: research

Clinical variables associated with the presence of articular pain in patients with temporomandibular joint clicking
AbstractObjectiveTo study and estimate the impact of clinical, somatosensory, and psychosocial variables associated with the concomitant presence of temporomandibular joint (TMJ) pain in patients with TMJ clicking.Materials and methodsNinety-three individuals composed the sample: patients with painful TMJ clicking (n = 47) and patients with painless TMJ clicking (n = 46). Four categories of data were evaluated: clinical features (gender, maximal interincisal distance (MID), side of complaint, age); bruxism (sleep bruxism (SB), awake bruxism (AB)); somatosensory (mechanical pain threshold (MPT), wind-up ratio (WUR), pressur...
Source: Clinical Oral Investigations - November 12, 2020 Category: Dentistry Source Type: research

The effect of sonic activation of irrigant on postoperative pain after root canal treatment in primary molar teeth: a randomized, clinical study
ConclusionsIt was determined that the use of SA reduces postoperative pain level significantly after root canal treatment in primary molar teeth.Clinical relevanceThe use of SA can be recommended to clinicians since it is effective in the successful management of postoperative pain of root canal treatment in primary molar teeth.Trial registrationClinicalTrials.gov ID: NCT04197531 (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - November 12, 2020 Category: Dentistry Source Type: research

The severity and extent of periodontitis is associated with cardio-ankle vascular index, a novel arterial stiffness parameter
AbstractObjectivesTo evaluate the association between the severity and extent of periodontitis and arterial stiffness using the cardio-ankle vascular index (CAVI).Materials and methodsA cross-sectional study of 2888 Electricity Generation Authority of Thailand (EGAT) employees aged 44 –78 years was conducted. The severity of periodontitis was evaluated based on mean clinical attachment level (CAL). The percentage of sites with CAL ≥ 5 mm was used to divide the extent of periodontitis into healthy (0%), localized (> 0 –
Source: Clinical Oral Investigations - November 12, 2020 Category: Dentistry Source Type: research

Evaluation of adipokines and inflammatory mediator expression levels in patients with periodontitis and peri-implantitis: a cross-sectional study
ConclusionsThe presence of current periodontitis may enhance expression levels of adiponectin, leptin, TNF- α, and IL-6 in peri-implant soft tissue.Clinical relevanceThe presence of periodontitis is an important risk factor for the severity of peri-implant inflammation as well as the onset of peri-implantitis. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - November 12, 2020 Category: Dentistry Source Type: research

Differences in the progression of experimental peri-implantitis depending on the implant to abutment connection
ConclusionsA platform switching connection resulted in a more benign development of peri-implantitis during the experimental induction phase of the disease. These differences, however, disappeared once the ligatures were removed (progression phase).Clinical relevanceInfluence of the implant-abutment connection in peri-implantitis progression may be relevant when considering implant selection in the moment of placement. In this sense, platform switching abutment demonstrated less peri-implantitis development when compared to implant matching connection. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - November 12, 2020 Category: Dentistry Source Type: research

Saliva substitute mouthwash in nasopharyngeal cancer survivors with xerostomia: a randomized controlled trial
This study was a prospective randomized clinical trial to compare the effects of saliva substitute mouthwash in nasopharyngeal cancer survivors with xerostomia, between two treatment arms, conducted in a tertiary center.Materials and methodsThis study measured the effects within 4 weeks in relation to summated xerostomia inventory (SXI) and unstimulated whole saliva (UWS). Patients randomized into the interventional arm were prescribed an immunologically active saliva substitute (IASS), while patients in the control arm were prescribed a non-immunologically active mouthwash as placebo.ResultsThe study population consisted ...
Source: Clinical Oral Investigations - November 11, 2020 Category: Dentistry Source Type: research

Periodontal clinical status, microbial profile, and expression of interleukin-1 β in men under androgenic anabolic steroids abuse
ConclusionsAAS intake can worsen clinical and immunological periodontal conditions and the biofilm composition in healthy sites.Clinical relevanceDental care professionals should perform full mouth periodontal screening and schedule regular follow-up appointments for patients under AAS use. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - November 11, 2020 Category: Dentistry Source Type: research

Significance of implant design on the efficacy of different peri-implantitis decontamination protocols
ConclusionThread geometry influenced the access of the decontamination devices and in turn its efficacy. Implants with lower thread pitch and thread depth values appeared to have less residual staining.Clinical relevanceClinicians must be aware of the importance of thread geometry in the decontamination efficacy. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - November 10, 2020 Category: Dentistry Source Type: research

Detection of Streptococcus mutans in symptomatic and asymptomatic infected root canals
ConclusionsS.mutans was found in high prevalence in both asymptomatic and symptomatic endodontic infections, including in abscesses, but it was not detected in the root canals of teeth with normal vital pulp. Interestingly,cnm+S.mutans was only detected in asymptomatic/chronic primary endodontic infections associated with apical lesion. Therefore, it appears thatcnm, and possibly other CBPs, may play an underestimated role in chronic endodontic infections.Clinical relevanceA high prevalence ofStreptococcus mutans cnm+ gene was detected only in asymptomatic primary endodontic infections associated with apical lesion. Theref...
Source: Clinical Oral Investigations - November 10, 2020 Category: Dentistry Source Type: research

Efficacy of laser monotherapy or non-surgical mechanical instrumentation in the management of untreated periodontitis patients. A systematic review and meta-analysis
ConclusionsIn untreated periodontitis patients, laser monotherapy does not yield superior clinical benefits compared with non-surgical mechanical instrumentation alone.Clinical relevanceIn untreated periodontitis patients, mechanical instrumentation with hand and/or ultrasonic instruments remains the standard of care. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - November 10, 2020 Category: Dentistry Source Type: research

Class II resin composite restorations —tunnel vs. box-only in vitro and in vivo
AbstractPurposeIn a combined in vitro/in vivo approach, tunnel vs. box-only resin composite restorations should be evaluated using thermomechanical loading (TML) in vitro and a restrospective clinical trial in vivo.Materials and methodsFor the in vitro part, box-only and tunnel cavities were prepared in 32 extracted human third molars under simulated intraoral conditions in a phantom head. Specimens were randomly assigned to four groups (n = 8; 16 box-only/16 tunnel) and received bonded resin composite restorations with Amelogen Plus (box A/tunnel A) or lining with Ultraseal and Amelogen plus (box B/tunnel B) both bonded u...
Source: Clinical Oral Investigations - November 9, 2020 Category: Dentistry Source Type: research

Compressive force strengthened the pro-inflammatory effect of zoledronic acid on il-1 ß stimulated human periodontal fibroblasts
ConclusionsBiomechanical stress might trigger a pro-inflammatory potential of BP further enhanced in the presence of an inflammatory pre-stimulation.Clinical relevanceTo prevent excessive host inflammatory responses, occlusal overloading and mechanical stress due to orthodontic treatment should be avoided in BP patients with untreated periodontitis. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - November 9, 2020 Category: Dentistry Source Type: research

Effectiveness of anesthetic solutions for pain control in lower third molar extraction surgeries: a systematic review of randomized clinical trials with network meta-analysis
Conclusion2% lidocaine + clonidine and 0.5% bupivacaine + adrenaline were the anesthetics with the highest probability for pain control immediately after the surgical procedure of removing impacted lower third molars.Clinical significanceThe use of an adequate anesthetic with effective pain control can contribute to a more comfortable postoperative period. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - November 8, 2020 Category: Dentistry Source Type: research

Proteomic analysis of human dental pulp in different clinical diagnosis
ConclusionsThe progression of the disease to inflamed pulp promoted a high abundance of proteins related to the immune system and stress. Comparing the necrotic pulp with inflamed pulp conditions, a high abundance of proteins was noticed related to metabolism, transport, and response between organisms.Clinical relevanceThis finding may assist in future studies of new markers, understanding of tissue engineering, and development of future products. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - November 7, 2020 Category: Dentistry Source Type: research

Complications or rather side effects? Quantification of patient satisfaction and complications after orthognathic surgery —a retrospective, cross-sectional long-term analysis
ConclusionsLong-term complications after orthognathic surgery occurred more frequently than commonly described in the literature, and analyses of the quality of life show the need for more comprehensive preoperative patient education.Clinical relevanceHypaesthesia of the lower lip presented less as complication but rather as side effect following BSSO. As orthognathic surgery is mostly elective, preoperative patient education is of pivotal importance and should include proactive risk stratification. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - November 6, 2020 Category: Dentistry Source Type: research

Multivariate analysis of the influence of peri-implant clinical parameters and local factors on radiographic bone loss in the posterior maxilla: a retrospective study on 277 dental implants
AbstractObjectivesThe aim of the present study was to investigate whether peri-implant clinical parameters (modified plaque index (mPI), bleeding and/or suppuration on probing (B/SOP)) and local factors (type of prostheses, screw emergence, platform diameter, and abutment angulation) might contribute to the development of additional bone loss and peri-implantitis around dental implants.Materials and methodsTwo hundred seventy-seven external hex connection implants placed in the posterior maxilla of 124 patients were retrospectively evaluated. They were divided into two groups: physiologic bone loss
Source: Clinical Oral Investigations - November 5, 2020 Category: Dentistry Source Type: research

Buffered 2% articaine versus non-buffered 4% articaine in maxillary infiltration: randomized clinical trial
AbstractObjectivesThis randomized, triple-blind, crossover clinical trial aimed to evaluate the efficacy, onset, length of pulp and soft tissue anesthesia, and pain during injection of 2% buffered articaine and 4% non-buffered articaine solutions.MethodsEach volunteer received two maxillary supraperiosteal anesthesia infiltrations in canine area. The infiltrations were performed at two different sessions using a different local anesthetic solution for each session, and the anesthetic injection speed was always 1 mL/min. The assessment of the onset and length of pulpal and soft tissue anesthesia was performed with the pulp ...
Source: Clinical Oral Investigations - November 5, 2020 Category: Dentistry Source Type: research

Lateral static overload on immediately restored implants decreases the osteocyte index in peri-implant bone: a secondary analysis of a pre-clinical study in dogs
ConclusionThe lower number of osteocytes in the peri-implant bone around overloaded implants could be related to the need for functional adaptation of the bone tissue to overloading and to the hypothesized involvement of the osteocytes in the maintenance of the bone matrix in the control group.Clinical relevanceOsteocytes play a pivotal role in bone adaptation to mechanical loading, and the osteocyte network has been regarded as being the main mechanosensory mechanism.Graphical Abstract (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - November 5, 2020 Category: Dentistry Source Type: research

The oral health status and treatment needs of children with fetal alcohol spectrum disorder
ConclusionsChildren with FASD may be at a higher risk for poor oral health outcomes and have more extensive treatment needs. Our results indicate that they may also be at a higher risk for treatment under GA.Clinical relevanceOral healthcare providers need to be award of the unique needs of children with FASD to better prevent and manage their oral disease. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - November 4, 2020 Category: Dentistry Source Type: research

Clinical characteristics and risk factors of major oral ulcers in the mandibular retromolar region in children
ConclusionsMjOU-P is a predominant form of MjOU in children and is a distinct subgroup of major ulcers that is likely associated with the development of the mandibular second molars.Clinical relevanceThis study is the first to describe the demographic and clinical features of MjOU in children, which may facilitate the identification and treatment of these patients. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - November 4, 2020 Category: Dentistry Source Type: research

Salivary inflammatory cytokines echo the low inflammatory burden in liver-transplanted children
ConclusionThe salivary inflammatory markers examined showed a similar pattern to the serum inflammatory values, though different markers were examined in the serum and saliva.Clinical relevanceThe current study stresses the potential of oral fluids as an accessible biofluid, for use as a diagnostic substrate for systemic and oral diseases.Trial registration0136-16-RMC, Registered on 01 March 2018 (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - November 2, 2020 Category: Dentistry Source Type: research

Silencing matrix metalloproteinase-13 (Mmp-13) reduces inflammatory bone resorption associated with LPS-induced periodontal disease in vivo
ConclusionsSite-specific inhibition of MMP-13 reduced bone resorption and production of inflammatory mediators associated with periodontal disease.Clinical relevanceThe results suggest that site-specific inhibition of MMP-13 may be an interesting strategy to modulate inflammation and reduce bone resorption in osteolytic inflammatory diseases. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - November 2, 2020 Category: Dentistry Source Type: research

Disruption of Enterococcus Faecalis biofilms using individual and plasma polymer encapsulated D-amino acids
ConclusionsPPEDAAs of various shell thickness can be produced with the proposed methodology, DAAs are subsequently released, and the anti-biofilm activity remains unaltered.Clinical relevanceIndividual DAAs and PPEDAAs have anti-biofilm ability and can be considered as part of a biological strategy in endodontics. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - November 2, 2020 Category: Dentistry Source Type: research

Ultrasonography-guided arthrocentesis versus conventional arthrocentesis in treating internal derangement of temporomandibular joint: a systematic review
ConclusionsThis systematic review found that the outcomes of USG-guided arthrocentesis were not superior to conventional arthrocentesis. Conflicting data was found in the attempts of needle positioning and procedural time. Standardized treatment protocols and data from well-designed USG-guided arthrocentesis randomized clinical trials were lacking.Clinical relevanceArthrocentesis with or without USG guidance are both effective for treating patients with TMD to reduce pain and to improve MMO. USG-guided arthrocentesis was not found to be superior to conventional arthrocentesis. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - October 8, 2020 Category: Dentistry Source Type: research

The effectiveness of microwave disinfection in treating Candida-associated denture stomatitis: a systematic review and metaanalysis
ConclusionMicrowave disinfection showed comparable results with those of conventional therapies for treating CADS. In addition, treatment with 650 W for 3 min once a week for 14 days had better cost-effect results, indicating both the prevention and treatment of CADS.Clinical relevanceOur findings provide evidence regarding the treatment of CADS using microwave disinfection, and also indicating the best cost-effective option for this treatment modality. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - October 8, 2020 Category: Dentistry Source Type: research

Local anaesthesia for surgical extraction of mandibular third molars: a systematic review and network meta-analysis
AbstractObjectivesPain management for the extraction of the mandibular third molar is a challenge as compelling evidence in comparative anaesthetics is currently lacking.Materials and methodsThorough literature searches took place in PubMed, ScienceDirect, CENTRAL, Embase, Web of Science, CBM, and CNKI. Thirty-three trials were meta-analysed using a Bayesian statistical approach within the random-effects model. Grading of Recommendations Assessment, Development, and Evaluation was performed to determine the overall quality of evidence across all comparisons.ResultsIn terms of success rate, an inferior alveolar nerve block ...
Source: Clinical Oral Investigations - October 8, 2020 Category: Dentistry Source Type: research

Genes in the pathway of tooth mineral tissues and dental caries risk: a systematic review and meta-analysis
ConclusionThe present findings showed that the genesTFIP11,AMBN, andAMELX play an important role in dental caries.Clinical relevanceSeveral single nucleotide polymorphisms related to the genes in the formation of tooth mineral are linked to the occurrence of dental caries, and these genes have proved to be important for an explanation of differences in the risk of dental caries. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - October 8, 2020 Category: Dentistry Source Type: research

The impact of cardiovascular disease and endodontic outcome: a systematic review of longitudinal studies
ConclusionWith the limitations of this systematic review, the overall confidence by GRADE was moderate suggesting that CVD might be a risk factor for endodontic outcomes.Clinical relevanceThe results support an association between CVD and endodontic outcomes. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - October 8, 2020 Category: Dentistry Source Type: research

Temporary materials: comparison of in vivo and in vitro performance
ConclusionsComparison of in vivo and in vitro aging led to no significant differences in fracture force and wear but differences in roughness, DSC, and TGA. SEM evaluation confirmed comparability. Comparison of CAD/CAM and cartridge temporary materials partially showed significant differences.Clinical relevanceIn vitro aging methods might be helpful to estimate materials ’ properties before principal clinical application. CAD/CAM and cartridge temporary materials provided comparable good clinical performance. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - October 8, 2020 Category: Dentistry Source Type: research

Role of hyaluronan in regulating self-renewal and osteogenic differentiation of mesenchymal stromal cells and pre-osteoblasts
ConclusionsHA strongly induces the growth of osteoprogenitors and maintains their stemness, thus potentially regulating the balance between self-renewal and differentiation during bone regeneration following reconstructive oral surgeries.Clinical relevanceAddition of HA to deficient bone or bony defects during implant or reconstructive periodontal surgeries may be a viable approach for expanding adult stem cells without losing their replicative and differentiation capabilities. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - October 8, 2020 Category: Dentistry Source Type: research

Characterization and effect of nanocomplexed fluoride solutions on the inhibition of enamel demineralization created by a multispecies cariogenic biofilm model
AbstractObjectivesThe aim of this study was to assess the in vitro caries preventive effect of nanocomplexed solutions of hydroxypropyl- β-cyclodextrin and γ-cyclodextrin associated with titanium tetrafluoride (TiF4) after different complexation times (12 or 72  h).Materials and methodsEnamel blocks were randomly distributed in 9 groups (n = 11): negative control, hydroxypropyl-β-cyclodextrin, γ-cyclodextrin, TiF4, hydroxypropyl- β-cyclodextrin:TiF4 12  h, hydroxypropyl-β-cyclodextrin:TiF4 72  h, γ-cyclodextrin:TiF4 12  h, γ-cyclodextrin:TiF4 72 ...
Source: Clinical Oral Investigations - October 8, 2020 Category: Dentistry Source Type: research

The relationship between molar incisor hypomineralization, dental caries, socioeconomic factors, and polymorphisms in the vitamin D receptor gene: a population-based study
ConclusionChildren with MIH presented a significant  higher prevalence of dental caries than children without MIH. To carry at least one G allele inrs739837 was associated to higher prevalence of MIH in molars and incisors.Clinical relevanceOur findings suggested that more severe cases with incisors affected by MIH could be associated with polymorphism inVDR gene. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - October 8, 2020 Category: Dentistry Source Type: research

Selenium intracanal dressing: effects on the periapical immune response
AbstractObjectivesTo evaluate the selenium (Se) behavior when used as an endodontic dressing in teeth with pulp necrosis. Additionally, its effects was also compared with the calcium hydroxide (C.H.), which is used globally as a root canal dressing, and the combination of the C.H. with Se (C.H. + Se).Materials and methodsThe sample consisted of 60 patients requiring endodontic treatment who were divided into groups, i.e., without intracanal medication (empty) and with medications as follows: selenium (Se), calcium hydroxide (C.H.), and calcium hydroxide + selenium (C.H. + Se) (n = 15). After the coronary open...
Source: Clinical Oral Investigations - October 6, 2020 Category: Dentistry Source Type: research

Is the high-performance thermoplastic polyetheretherketone indicated as a clasp material for removable dental prostheses?
AbstractObjectivesTo investigate the retention force of polyetheretherketone (PEEK) removable dental prosthesis clasps in comparison with a cobalt-chrome-molybdenum control group after storage in artificial saliva.Materials and MethodsClasps were milled (Dentokeep (PEEKmilled1), NT digital implant technology; breCAM BioHPP Blank (PEEKmilled2), bredent), pressed (BioHPP Granulat for 2 press (PEEKpressed), bredent), or cast (remanium GM 800+ (cobalt-chrome-molybdenum), Dentaurum);N = 60,n = 15/subgroup. Retention force was examined 50 times/specimen in a pull-off test using the universal testing machine (Zwick 1445), where p...
Source: Clinical Oral Investigations - October 6, 2020 Category: Dentistry Source Type: research

Retrospective analysis of complications in 190 mandibular resections and simultaneous reconstructions with free fibula flap, iliac crest flap or reconstruction plate: a comparative single centre study
ConclusionsMicrovascular bone flaps have overall less skin perforation than reconstruction plates. BMI and expected total radiation dosage have to be respected in choice of reconstructive technique.Clinical relevanceA treatment algorithm for mandibular reconstructions on the basis of our results is presented. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - October 5, 2020 Category: Dentistry Source Type: research

Application of a surgical guide in the extraction of impacted mesiodentes: a randomized controlled trial
ConclusionsDespite some limitations, the surgical guide assisted with mesiodentes extraction and can improve the quality of the operation quality as well as reducing its economic burden, difficulty, and duration. Through proper design, we can create a high-quality surgical guide using only CBCT data.Clinical relevanceThe surgical guide can be used as an important assistive tool in alveolar surgery. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - October 5, 2020 Category: Dentistry Source Type: research

National oral health survey on refugees in Germany 2016/2017: caries and subsequent complications
ConclusionThe refugees had high caries experience, often untreated caries teeth and more complications compared with the German resident population, especially in children. Closing this gap by extending preventive systems to the refugees would decrease future treatment needs.Clinical relevanceEuropean countries should be prepared for the higher dental treatment needs in recent refugees, especially in children. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - October 3, 2020 Category: Dentistry Source Type: research

Blood-based circulating microRNAs as potential biomarkers for predicting the prognosis of head and neck cancer —a systematic review
ConclusionBased on the results, circulating miRNA may assist in the prediction of prognosis of head and neck cancer. Further multi-center randomized controlled clinical trials with large sample size are required to validate the results of the present review.Clinical relevanceDecoding the circulating miRNA profile could aid in accurate prognostication of head and neck cancer. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - October 2, 2020 Category: Dentistry Source Type: research

The gain-of-function FAM83H mutation caused hypocalcification amelogenesis imperfecta in a Chinese family
ConclusionsWe verified the FAM83H p.Lys639* protein as a gain-of-function variant causing ADHCAI. Abnormal enamel rod head structure was observed in teeth with mutant FAM83H proteins. We also investigated the molecular pathogenesis and presented data on the abnormal degradation of mutant FAM83H proteins.Clinical relevanceThis study helped the family members to understand the disease progression and provided new insights into the pathogenesis of ADHCAI. Due to the large heterogeneity of ADHCAI, this study also provided a genetic basis for individuals who exhibit similar clinical phenotypes. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - October 1, 2020 Category: Dentistry Source Type: research

Longevity of posterior composite restorations in children suffering from early childhood caries —results from a retrospective study
ConclusionSystemic disease has a detrimental influence over longevity of composite restorations. Therefore, considering the reduced survival rates of the composite restorations for children who have systemic disease, alternative non-invasive treatment options should be considered.Clinical relevanceThis study ’s novelty is the observation of drastically reduced survival of composite restorations in children with systemic disease. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - October 1, 2020 Category: Dentistry Source Type: research

Biocompatibility, mechanical, and bonding properties of a dental adhesive modified with antibacterial monomer and cross-linker
This study investigated the antibacterial, cytotoxicity, and mechanical properties of a dental adhesive modified with quaternary ammonium monomer ((2-acryloyloxyethyl)dimethyldodecylammonium bromide) and cross-linker (bis(2-acryloyloxyethyl)methyldodecylammonium bromide).Materials and methodsMonomer (M), cross-linker (C), or a combination of these (M + C) were incorporated into adhesive Adper Single Bond Plus (SB) in 5, 10, or 25% (as wt%). A colony-forming unit and MTT assays were used to evaluate antibacterial properties againstStreptococcus mutans and cell viability. Resin-dentin beams (0.9 ± 0.1 mm2) were evalua...
Source: Clinical Oral Investigations - October 1, 2020 Category: Dentistry Source Type: research