The precision of case difficulty and referral decisions: an innovative automated approach
ConclusionThis study provides an option for automation to the conventional method of predicting the difficulty level of a case, thus increasing the speed of decision-making and referrals if necessary.Clinical relevanceAn AAE Endodontic Case Difficulty Assessment Form when utilized along with machine learning can assist general dentists in rapid assessment of the case difficulty. This is a helpful tool in developing countries, where endodontic treatment and referral guidelines are often neglected. It also helps to make difficulty level assessments easier for novice practitioners, when they are in doubt about the same. (Sour...
Source: Clinical Oral Investigations - May 29, 2020 Category: Dentistry Source Type: research

Regulation of matrix metalloproteinase-1 by Filifactor alocis in human gingival and monocytic cells
ConclusionsOur results demonstrate thatF. alocis and MMP-1 are more prevalent at periodontitis sites. Additionally, our study provides original evidence thatF. alocis can stimulate MMP-1 production by fibroblastic and monocytic cells, suggesting thatF. alocis may contribute to periodontal breakdown through MMP-1.Clinical relevanceF. alocis and MMP-1 are linked to each other and key players in periodontitis, which may have significant implications for future diagnostic and treatment strategies. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - May 29, 2020 Category: Dentistry Source Type: research

Second primary tumors in proliferative verrucous leukoplakia: a series of 33 cases
AbstractObjectivesTo describe the number of second primary malignancies in a series of 33 patients with proliferative verrucous leukoplakia (PVL), detailing the mean time between primary malignancies and their clinical characteristics.Materials and methodsTwo groups of patients were included in this study: group 1 comprised 33 PVL patients who had developed ≥ 2 oral squamous cell carcinoma (OSCC) and group 2 comprised 48 PVL patients without malignant degeneration. We compared the groups with regard to age, gender, oral location, and number of oral sites affected. For patients in group 1, we determined the locati...
Source: Clinical Oral Investigations - May 29, 2020 Category: Dentistry Source Type: research

In vitro remineralization of enamel white spot lesions with a carrier-based amorphous calcium phosphate delivery system
AbstractObjectivesTo achieve in vitro remineralization of enamel white spot lesions (WSLs) via a mesoporous delivery system of amorphous calcium phosphate (ACP) precursors.Materials and methodsAmine-functionalized expanded pore mesoporous silica (aMSN) was loaded with polyacrylic acid –stabilized amorphous calcium phosphate (PAA-ACP) to develop a carrier-based delivery system (PAA-ACP@aMSN). Thirty-six artificial WSLs samples were created and randomly assigned to three treatments: artificial saliva solution (negative control,n = 12), casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) slurry (n&...
Source: Clinical Oral Investigations - May 29, 2020 Category: Dentistry Source Type: research

Oro-facial manifestations in lepromatous leprosy patients in Central India: clinical findings from a cross-sectional study
ConclusionThe facial manifestations of leprosy are quite common, readily recognizable, and relatively specific to the disease. Thus, the presence of facial manifestations, especially with co-existing oral lesions must prompt the clinician to mandate further investigations to confirm the diagnosis.Clinical relevanceAs evidenced by the present study, facial manifestations and oral lesions are an integral part of leprosy. In addition to being a diagnostic parameter, facial manifestations and oral lesions could potentially be used to monitor the disease progression and treatment outcome. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - May 29, 2020 Category: Dentistry Source Type: research

OHRQoL changes among Chinese preschool children following dental treatment under general anesthesia
AbstractObjectiveTo assess dental treatment under dental general anesthesia (DGA) among Chinese preschool children by investigating changes in their oral health-related quality of life (OHRQoL), the incidence of postoperative complications, and parental satisfaction.MethodA single-center prospective cohort study was conducted. A total of 190 children who received treatment for early childhood caries (ECC) under DGA were included. The primary outcome was a change in the children ’s OHRQoL at 1 month after the operation compared to that at baseline, which was measured by the Early Childhood Oral Health Impact Scal...
Source: Clinical Oral Investigations - May 29, 2020 Category: Dentistry Source Type: research

Clinical significance of the G8 screening tool in elderly patients with oral squamous cell carcinoma
AbstractObjectivesThe present study investigated the clinical significance of the G8 screening tool in elderly oral squamous cell carcinoma (OSCC) patients using a multicenter analysis.Materials and methodsThe medical records of 438 primary OSCC patients aged 75  years and older were retrospectively reviewed. To examine the clinical significance of the G8 screening tool in elderly OSCC patients, self-reliance (SR) rates and prognostic factors were statistically analyzed.ResultsThe mean score of the G8 screening tool was 10.9  ± 2.93. The SR cut-off value of the G8 score was 9.5 in a receiver opera...
Source: Clinical Oral Investigations - May 29, 2020 Category: Dentistry Source Type: research

Oral health status and impact on the oral health-related quality of life of Egyptian children and early adolescents with type-1 diabetes: a case-control study
ConclusionsThe overall self-reported OHRQL appears to be adversely affected by T1DM especially among children and early adolescents with poor metabolic control. Socioeconomic status and oral health care demonstrate a significant impact on the OHRQoL; however, the effect was obvious in the diabetic and non-diabetic groups.Clinical relevance1. In Egypt, the number of new cases rises progressively in a retrospective survey to figure out the prevalence of T1DM among children and adolescents. The available data is limited regarding the incidence and prevalence of dental caries and gingival condition among Egyptian children and ...
Source: Clinical Oral Investigations - May 28, 2020 Category: Dentistry Source Type: research

Influence of de-remineralization process on chemical, microstructural, and mechanical properties of human and bovine dentin
This study compared the chemical composition, microstructural, and mechanical properties of human and bovine dentin subjected to a demineralization/remineralization process.Materials and methodsHuman and bovine incisors were sectioned to obtain 120 coronal dentin beams (6  × 1 × 1 mm3) that were randomly allocated into 4 subgroups (n = 15) according to the time of treatment (sound, pH-cycling for 3, 7, and 14 days). Three-point bending mechanical test, attenuated total reflectance–Fourier transform infrared (ATR-FTIR), thermogravimetric (TG), and X-ray d...
Source: Clinical Oral Investigations - May 27, 2020 Category: Dentistry Source Type: research

Effect of calcium hydroxide mixed with lidocaine hydrochloride on postoperative pain in teeth with irreversible pulpitis and symptomatic apical periodontitis: a preliminary randomized controlled prospective clinical trial
ConclusionWithin the limitations of this study, it can be concluded that the calcium hydroxide mixed with lidocaine HCl can be beneficial in reducing postoperative pain in teeth with irreversible pulpitis and symptomatic apical periodontitis.Clinical relevanceThe calcium hydroxide mixed with lidocaine HCl can be beneficial in reducing postoperative pain in teeth with irreversible pulpitis and symptomatic apical periodontitis.Clinical registration numberTCTR20181121003 (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - May 27, 2020 Category: Dentistry Source Type: research

Effect of interdental brush design on plaque during nonsurgical periodontal therapy
AbstractObjectiveThe aim of this randomized controlled trial was to evaluate the interproximal cleaning efficacy of waist-shaped compared with straight soft interdental brushes in patients undergoing nonsurgical periodontal therapy.Materials and methodsTen patients diagnosed with periodontitis stage II or III were scheduled for nonsurgical periodontal therapy. Baseline plaque control record (PCR), modified approximal plaque index (API), papillary bleeding index (PBI), probing pocket depth (PPD), and bleeding on probing (BOP) were evaluated. Four interdental spaces of equal sizes were determined, and baseline plaque indices...
Source: Clinical Oral Investigations - May 27, 2020 Category: Dentistry Source Type: research

Investigating the effect of bicarbonate ion on the structure and strength of calcium silicate-based dental restorative material —Biodentine
ConclusionsOur results indicate that Biodentine exhibited higher strength in the presence of bicarbonate, which can be explained by the carbonation process that encouraged the formation of calcium carbonate on the cement ’s surface.Clinical relevanceCarbonation should be of more consideration when studying calcium silicate-based cements, with curing and testing conditions closer to the intraoral conditions. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - May 26, 2020 Category: Dentistry Source Type: research

Immediate versus delayed application of bone morphogenetic protein-2 solution in damaged extraction sockets: a preclinical in vivo investigation
ConclusionsDelayed application of BMP-2 2  weeks after surgery did not show any advantage over immediate application of BMP-2 in terms of new bone formation.Clinical relevanceThis study suggests that it might be better to apply BMP-2 immediately in alveolar ridge preservation, instead of delayed application, in order to enhance new bone formation. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - May 26, 2020 Category: Dentistry Source Type: research

Saliva as an alternative to blood in the determination of uremic state in adult patients with chronic kidney disease: a systematic review and meta-analysis
ConclusionCompared with blood samples, salivary urea and creatinine levels presented high diagnostic values for chronic kidney disease screening, but should not be considered equivalent to levels obtained from blood at stages three, four, or five of the disease.Clinical significanceChronic kidney disease patients could receive a clinically significant benefit from replacing blood with saliva for potentially monitoring renal function. Saliva collection presents greater simplicity, comfort, safety, and lower collection cost. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - May 23, 2020 Category: Dentistry Source Type: research

Macrophages skew towards M1 profile through reduced CD163 expression in symptomatic apical periodontitis
AbstractObjectivesTo explore the macrophage profiles in symptomatic and asymptomatic forms of AP through phenotypic and functional analyses.Material and methodsCross-sectional study. Apical tissue/lesion samples were collected from patients with clinical diagnosis of AAP (n = 51) or SAP (n = 45) and healthy periodontal ligament (HPL) from healthy patients as controls (n = 14), all with indication of tooth extraction. Samples were digested, cells were stained for CD14, M1 (CD64, CD80), and M2 (CD163, CD206) phenotypic surface markers and analyzed by flow cytometry. Functional cytoki...
Source: Clinical Oral Investigations - May 22, 2020 Category: Dentistry Source Type: research

Differences between auto-fluorescence and tetracycline-fluorescence in medication-related osteonecrosis of the jaw —a preclinical proof of concept study in the mini-pig
ConclusionNeither in vivo nor in vitro macroscopically differences are apparent between the auto-fluorescence and the tetracycline-fluorescence of bone. The auto-fluorescence is attributable to the arrangements and structure of collagen and the cell-filled bone lacunae. Tetracycline-fluorescence is a mixture of tetracycline (at the bone edges with increased bone formation) and large components of auto-fluorescence.Clinical relevanceBecause auto-fluorescence is easy to apply, reproducible, and does not rely on the subjective impression of the surgeon, it promises to be an important standardized alternative to tetracycline-l...
Source: Clinical Oral Investigations - May 22, 2020 Category: Dentistry Source Type: research

Comparison of two vasoconstrictors on glycemic levels in diabetic patients
ConclusionThus, both lido/epi and prilo/fely (maximum 3.6 mL) can be safely used in controlled diabetic patientsClinical relevanceThe use of lidocaine associated with epinephrine did not increase glycemic levels but leads to decrease over time when associated with an anxiety reduction protocol, offering some advantage over prilocaine plus felypressin for diabetic patients. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - May 22, 2020 Category: Dentistry Source Type: research

Association between condylar position changes and functional outcomes after condylar reconstruction by free fibular flap
AbstractObjectivesStable and appropriate condyle positioning is necessary for maintaining temporomandibular joint function. It is unclear if this position remains stable in patients after free fibular flap (FFF) condylar reconstruction. We investigated whether condylar position deviated after reconstruction, and whether this affected functional recovery.Materials and methodsWe retrospectively reviewed 43 patients who underwent conventional FFF condylar reconstruction, and 5 patients who underwent reconstruction by computer-assisted three-dimensional (3D) printing methods. Three-dimensional models were built from cone-beam ...
Source: Clinical Oral Investigations - May 21, 2020 Category: Dentistry Source Type: research

Root coverage of gingival recessions with non-carious cervical lesions: a controlled clinical trial
ConclusionGR associated with NCCLs can be successfully treated with the ECDF and ADMG.Clinical relevancePatients frequently search for GR treatment due to cervical wear, root sensitivity, and compromising aesthetics. The NCCL participates with the same issues. The present study contributes to the literature that GR associated with NCCLs can be successfully treated with the ECAF and the ADMG. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - May 21, 2020 Category: Dentistry Source Type: research

Accuracy of CAD/CAM-fabricated bite splints: milling vs 3D printing
AbstractObjectivesThe aim of this study was to investigate the accuracy of CAD/CAM-fabricated bite splints in dependence of fabrication method (milling vs 3D printing), positioning (horizontal vs vertical), selection of material, and method of deviation measurement.Materials and methodsBite splints were 3D-printed in either horizontal or vertical position (n = 10) using four different resins (Dental LT, Ortho Clear, Freeprint Splint, V-Splint). As control, ten bite splints were fabricated by CNC milling (ProArt CAD Splint). The splints were scanned and deviations between the CAD-file (trueness) and between each other withi...
Source: Clinical Oral Investigations - May 21, 2020 Category: Dentistry Source Type: research

Tooth loss is associated with atherosclerosis and a poorer functional outcome among stroke patients
ConclusionTooth loss was independently associated with CAB and predicted a poorer functional outcome among IS and TIA patients.Clinical relevanceClinical assessment of tooth loss may provide important information on risk for CAB and poorer functional outcome among stroke patients. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - May 21, 2020 Category: Dentistry Source Type: research

Inhibition of neutrophil inflammatory mediator expression by azithromycin
ConclusionAZM is a consistent and effective inhibitor of neutrophil inflammatory mediator mRNA expression.Clinical relevanceGiven that a single dose of AZM produces higher and more sustained concentrations of this agent in periodontal tissues than AMX when used as a pre-operative prophylactic antibiotic, AZM has greater potential to inhibit inflammatory mediator expression at peri-implant wound sites than AMX. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - May 21, 2020 Category: Dentistry Source Type: research

Dietary fatty acids and the time elapsed from their intake are related to their composition in rat submandibular gland and salivary flow rates
AbstractObjectivesThe aim of this study was to analyze the influence of dietary fatty acids (FAs) and the time elapsed from their intake on FA tissue profile of rat submandibular gland (SG) and on its salivary flow rate (SFR). Do dietary FAs depending on the intake time modify their profile in SG and consequently the SFR?Materials and methodsThirty-six adult male Wistar rats were fed on control diet (corn oil, CD, 18:2 n-6 FA) for 7  days and then divided into CD and two groups with replacement of corn oil by olive (OD, 18:1 n-9 FA) or chia (ChD, 18:3 n-3 FA) oils (1 and 30 day intake). Submandibular ducts were c...
Source: Clinical Oral Investigations - May 21, 2020 Category: Dentistry Source Type: research

Effect of orally administered magnesium on postoperative pain level and trismus after surgical removal of the lower third molars: a randomized, double-blind, placebo-controlled trial
AbstractObjectivesPain and trismus are the most common postoperative complications following a surgical removal of the lower third molar. This randomized, double-blind, placebo-controlled clinical trial evaluated the effect of orally administrated magnesium on postoperative pain and trismus after surgical removal of the lower third molars.Materials and methodsThe study was conducted on 80 participants who were divided into two groups. Each group took different oral forms of magnesium citrate. Participants in both groups had their two lower molars surgically removed. For one randomly selected third molar, participants recei...
Source: Clinical Oral Investigations - May 20, 2020 Category: Dentistry Source Type: research

Influence of intraoral scanning on the quality of preparations for all-ceramic single crowns
AbstractObjectivesTo evaluate the influence of intraoral scanning on the quality of preparations for all-ceramic single crowns.Material and methodsA total of 690 randomly selected and anonymized in vivo single crown preparations were examined. Three hundred twenty-three preparations were directly recorded with an intraoral scanner (group IS). Data from plaster casts digitized by a laboratory scanner (group ID;N = 367) served as control. Comparisons included convergence angle, marginal design, marginal substance reduction, homogeneity of the finish line, and undercuts. Evaluation was performed using fully automated speciali...
Source: Clinical Oral Investigations - May 20, 2020 Category: Dentistry Source Type: research

Malignant transformation of oral leukoplakia: a follow-up study
AbstractObjectiveThe main objective of the study was to identify the determinants that contribute to the malignant transformation of oral leukoplakia in a group of patients managed in secondary care. A secondary objective was to compare two dysplasia grading systems to determine their utility in assessing the prognosis.Material and methodsThe cohort consisted of 93 patients diagnosed during the period 2009 –2013. The variables recorded and analysed included age and sex, clinical presentation (colour) and severity of oral epithelial dysplasia (OED) scored by the WHO (2005) and the binary grading systems. The planned m...
Source: Clinical Oral Investigations - May 20, 2020 Category: Dentistry Source Type: research

Clinical efficacy of xenogeneic collagen matrix in augmenting keratinized mucosa round dental implants: a systematic review and meta-analysis
ConclusionsThe use of XCM improved KMW and PD with rates comparable to those for CTG. XCM showed lower results for GT when compared to CTG. XCM presented similar results in terms of PAS when compared to CTG.Clinical relevanceThe presence of a KMW around dental implants is associated with better peri-implant tissue health. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - May 19, 2020 Category: Dentistry Source Type: research

COVID-19 outbreak: succinct advice for dentists and oral healthcare professionals
(Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - May 19, 2020 Category: Dentistry Source Type: research

Comparison of clinical efficacy and patient acceptance of interdental brush and silicone coated interdental pick: a randomized split-mouth, prospective clinical trial
ConclusionThe clinical efficiency of the tested interdental devices was similar in terms of removing plaque and decreasing bleeding. However, SCIP were found to be more comfortable and preferable to IDB.Clinical relevanceThe silicone coated interdental picks showed similar effects on plaque removal as interdental brushes and superiority in terms of ease to use than interdental brushes. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - May 19, 2020 Category: Dentistry Source Type: research

Effect of treatment with a full-occlusion biofeedback splint on sleep bruxism and TMD pain: a randomized controlled clinical trial
ConclusionsThe tested BFB splint is highly effective in reducing SB at the subconscious level, i.e., without waking the patient, and in achieving improvements in global pain perception. The results suggest that the BFB splint also provides a better treatment option for bruxism-related pain than an AOS. However, further research is needed, and specifically studies with a larger patient population displaying higher levels of pain at baseline.Clinical relevanceBy reducing burst duration and therefore the pathological load on the masticatory apparatus, the BFB splint reduces TMD and bruxism-related symptoms and improves patien...
Source: Clinical Oral Investigations - May 19, 2020 Category: Dentistry Source Type: research

DNA double-strand breaks of human peripheral blood lymphocyte induced by CT examination of oral and maxillofacial region
AbstractObjectivesTo explore whether a computed tomography (CT) examination of the head and neck region induces biological damage and whether the damage was correlated with the radiation dose.Materials and methodsPeripheral blood was taken from 33 individuals who received head and neck CT examinations. Blood samples were divided into three groups: the control group and the in vivo and in vitro irradiation groups. The number of DNA double-strand breaks was estimated by comparing the changes in the rates of γ-H2AX foci formation in the peripheral blood before and after CT examination. The absorbed dose and effective do...
Source: Clinical Oral Investigations - May 18, 2020 Category: Dentistry Source Type: research

Impact of fabrication procedures on residual monomer elution of conventional polymethyl methacrylate (PMMA) —a measurement approach by UV/Vis spectrophotometry
AbstractObjectivesTo analyse the residual monomer (MMA) elution of polymethyl methacrylate (PMMA) in distilled water after diverse fabrication methods and aging procedures.Materials and methodsPMMA specimens (N = 192, PalaXpress; Kulzer, Hanau, Germany) were manufactured (pouring,n = 96/injection,n = 96) and polymerized in water (55 °C) without pressure (n = 48) and with 2 bar pressure (n = 48). Specimens were grinded (n = 24) or polished (n = 24) and aged for 12 h in distilled water/37 °C (n = 12) or at air/20 °C (n = 12) and stored afterwards in distilled water at 37 °C. MMA elution was evaluated after 1,...
Source: Clinical Oral Investigations - May 18, 2020 Category: Dentistry Source Type: research

Comparison of the effects of injectable platelet-rich fibrin and autologous fibrin glue applications on palatal wound healing: a randomized controlled clinical trial
AbstractObjectiveThe aim of this study was to compare the effects of AFG and i-PRF on palatal wound healing and postoperative discomfort.Materials and methodsThirty-six patients in need of FGG were divided into three groups. AFG (n = 12) or i-PRF (n = 12) was applied and compared with control group (n = 12). Wound healing with H2O2 test, VAS, MSS, and LTH index were evaluated on the 3rd,7th, and 14th days and 1st month. The bleeding status was evaluated on the 3rd and 7th days. Palatal tissue thickness was measured at baseline, 1st month, and 3rd month.ResultsEpithelialization was higher in the test groups on the 14th day ...
Source: Clinical Oral Investigations - May 18, 2020 Category: Dentistry Source Type: research

Cleanliness and erosion of root canal walls after irrigation with a new HEDP-based solution vs. traditional sodium hypochlorite followed by EDTA. A scanning electron microscope study
AbstractObjectivesTo compare the cleanliness and erosion of root canal walls after the use of a new HEDP (1-hydroxyethane-1,1-diphosphonic acid) -based irrigant with that achieved by irrigation with sodium hypochlorite followed by EDTA.Materials and methodsForty recently extracted single-rooted teeth were prepared with ProTaper Next files to size X3, using either HEDP-containing 3% sodium hypochlorite, throughout the procedure (n = 20), or 3% sodium hypochlorite followed by a final rinse with 17% EDTA (n = 20), which were both applied with a syringe and needle. Ten additional teeth were prepared...
Source: Clinical Oral Investigations - May 16, 2020 Category: Dentistry Source Type: research

The effectiveness of ultrasound examination to assess the healing process of bone lesions of the jaws: a systematic review
ConclusionsUSE implemented with color power Doppler is an advanced imaging technique feasible to monitor the early and long-term response of the intra-osseous lesions of the jaws to both surgical and nonsurgical treatment.Clinical relevanceThis systematic review brought evidence that USE can constitute a safe alternative imaging technique in the dental clinical practice for the management of central lesions of the maxillary bones. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - May 16, 2020 Category: Dentistry Source Type: research

Efficacy of growth factors for the treatment of peri-implant diseases: a systematic review and meta-analysis
AbstractObjectivesThe aim of this study was to conduct a systematic review and meta-analysis on the efficacy of growth factors (GF) on clinical outcomes after treatment (surgical/non-surgical) of peri-implant diseases (peri-implant mucositis and peri-implantitis).Materials and methodsA protocol was developed to answer the following focused question: Is there any difference for the use of GF for treatment of peri-implant diseases versus comparative GF treatment or without GF? Electronic database and manual searches were independently conducted to identify randomized controlled trials (RCTs). Publications were selected based...
Source: Clinical Oral Investigations - May 16, 2020 Category: Dentistry Source Type: research

Multi-modular bone healing assessment in a randomized controlled clinical trial of root-end surgery with the use of leukocyte- and platelet-rich fibrin and an occlusive membrane
ConclusionsThere was no evidence for improvement of bone healing when RES was applied with LPRF in comparison with RES without LPRF. However, RES with BG gave evidence for a better outcome than RES without BG.Clinical relevanceThe addition of an occlusive membrane rather than an autologous platelet concentrate improved bone regeneration 1  year post RES significantly, irrespective of the assessment device applied. The accuracy of PR assessment is questionable. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - May 16, 2020 Category: Dentistry Source Type: research

Peri-implant disease affects systemic complete blood count values —an experimental in vivo study
AbstractObjectivesTo assess complete blood count (CBC) dynamics following ligature removal and open flap debridement in experimental peri-implantitis in dogs.Materials and methodsSeven male beagle dogs were included in the study. Four rough-surface implants were placed pair-wise in both sides of the mandible 14 weeks after tooth extraction. Second stage surgery was performed after 14 weeks. Experimental peri-implantitis was initiated 3 weeks later by ligature placement around the healing caps thus facilitating plaque accumulation and inducing inflammation and destruction of peri-implant tissues. Ligature removal and open f...
Source: Clinical Oral Investigations - May 16, 2020 Category: Dentistry Source Type: research

Application of BMP-2/FGF-2 gene –activated scaffolds for dental pulp capping
ConclusionTransfection of DPSCs with pBMP-2/pFGF-2 nanoplexes resulted in increased expression of BMP-2 and FGF-2, enhanced proliferation, and mineralization properties compared to MTA. These findings were supported by the ex vivo observations.Clinical relevanceThis biological approach in pulp capping brings new insights into the effective management of engineered pulp tissues, mainly those generated by the transplantation of DPSCs in empty root canals. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - May 15, 2020 Category: Dentistry Source Type: research

Ineffectiveness of ozone therapy in nonsurgical periodontal treatment: a systematic review and metaanalysis of randomized clinical trials
ConclusionsThe results of this SR do not support the use of OT for nonsurgical periodontal treatment. However, due to the potential heterogeneity across the studies, the presence of confounding factors, and the short follow-up of some included RCTs, these results should not be considered definitive.Clinical relevanceThe current evidence indicates that ozone has antimicrobial activity and good biocompatibility with periodontal cells and gingival fibroblasts. However, no evidence was found for a positive effect of OT as an adjunct to scaling and root planing. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - May 12, 2020 Category: Dentistry Source Type: research

In vivo wear of CAD-CAM composite versus lithium disilicate full coverage first-molar restorations: a pilot study over 2  years
AbstractObjectivesTo present a digital approach to measure and compare material wear behavior of antagonistic first molar restorations made of an experimental CAD/CAM composite (COMP) and lithium disilicate ceramic (LS2) in patients with reconstructed vertical dimension of occlusion (VDO) after generalized hard tissue loss.MethodsA total of 12 patients underwent complete full jaw rehabilitation with full occlusal coverage restorations made either of COMP or LS2. The first molar restorations (n = 48) were chosen for wear examination. At annual recall appointments, polyether impressions were taken, and resulting ...
Source: Clinical Oral Investigations - May 12, 2020 Category: Dentistry Source Type: research

A randomized, controlled, two-month pilot trial of stannous fluoride dentifrice versus sodium fluoride dentifrice after oxalate treatment for dentinal hypersensitivity
ConclusionsIn subjects treated with oxalates for dentinal hypersensitivity, both stannous fluoride and sodium fluoride dentifrices are well tolerated, are feasible for routine use, and do not detract from the desensitizing effects of an in-office and at-home oxalate combination treatment regimen.Clinical relevanceEither stannous fluoride or sodium fluoride dentifrices can be recommended to dentinal hypersensitivity patients who undergo professional oxalate treatment. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - May 10, 2020 Category: Dentistry Source Type: research

Effect of nonsurgical periodontal therapy on haematological parameters in grades B and C periodontitis: an exploratory analysis
AbstractAimAssessment of the effect of nonsurgical periodontal therapy on haematological parameters in patients with grades B (BP) and C periodontitis (CP).MethodsEight BP and 46 CP patients received full-mouth periodontal debridement within 48  h, if positive forAggregatibacter actinomycetemcomitans with adjunctive systemic antibiotics (4 BP, 17 CP). Clinical data were collected prior and 12  weeks after periodontal therapy. Blood was sampled prior to and 1 day as well as 6 and 12 weeks after the first SD visit. Erythrocyte count, haemoglobin value, haematocrit (HCT), mean erythrocyte volume (MCV), mea...
Source: Clinical Oral Investigations - May 8, 2020 Category: Dentistry Source Type: research

Correlation of molecular biomarker concentrations between synovial fluid and saliva of the patients with temporomandibular disorders
ConclusionsChemerin, MMP-2, and PGE2 can play a role as an inflammatory factor for the development of TMJ disorder.Clinical relevanceThe search for molecular markers in TMJ and the inhibition of the associated molecular signaling mechanism is important to reduce joint inflammation and cartilage degradation. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - May 8, 2020 Category: Dentistry Source Type: research

Transforaminal and systemic diffusion of an active agent from a zinc oxide eugenol-based endodontic sealer containing hydrocortisone —in an in vivo model
ConclusionsThis study demonstrated that radioactive-HCA from Endomethasone N can diffuse through the apex of the root canal and follow a classical pharmacokinetics.Clinical relevanceThis mouse model shows that radioactive-HCA can diffuse through the apex and do not accumulate in periapical-like tissues and organs. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - May 8, 2020 Category: Dentistry Source Type: research

Taste disorder ’s management: a systematic review
ConclusionImproving oral hygiene may promote taste ability. Zinc may prevent and alleviate taste disorder in patients undergoing head and neck radiotherapy.Clinical relevanceThe systematic review provided evidence about the clinical efficacy of oral procedures, zinc supplementation, and palliative cares in dysgeusic patients. Further research is needed to find effective treatments with low adverse effects. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - May 8, 2020 Category: Dentistry Source Type: research

The MB3 canal in maxillary molars: a micro-CT study
ConclusionsMB3 canal is a rare anatomical variation present in maxillary first and second molars. Its presence can be associated to a complex internal anatomy of the MB root which includes the presence of isthmuses and multiple accessory canals and foramina at the apical third, but also a thin dentine thickness at the coronal third and a confluent anatomy of the MB3 with the other main canals. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - May 7, 2020 Category: Dentistry Source Type: research

Tunnel technique with enamel matrix derivative in addition to subepithelial connective tissue graft compared with connective tissue graft alone for the treatment of multiple gingival recessions: a randomized clinical trial
ConclusionsBoth treatment modalities were equally effective in treatment of multiple GR and led to similar improvements in clinical parameters. However, the application of EMD as an adjunct resulted in less post-operative pain and better professionally assessed esthetic outcomes.Clinical relevancePatients ’ early morbidity and 6-month esthetic outcomes following GR coverage with MCAT might be influenced by means of EMD utilization. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - May 7, 2020 Category: Dentistry Source Type: research

Three-dimensional characterization of mandibular asymmetry in craniofacial microsomia
This study aimed to investigate the three-dimensional (3D) mandibular asymmetry in craniofacial microsomia (CFM) and its association with the Pruzansky –Kaban classification system.Materials and methodsCone-beam computed tomography images of 48 adult CFM cases were collected. The asymmetry of the mandibular body and ramus was analyzed with 3D landmarks. The mirrored mandibular model was registered on the original model, yielding a color-coded distance map and an average distance (i.e., asymmetry score) to quantify the overall mandibular asymmetry.ResultsThe lengths of the mandibular body and ramus were significantly ...
Source: Clinical Oral Investigations - May 7, 2020 Category: Dentistry Source Type: research

Influence of a programme for prevention of early childhood caries on early orthodontic treatment needs
ConclusionsThe PP was an effective approach for preventing caries-related premature tooth loss in children and conserving relevant arch length.Clinical relevanceChildren who received continuous dental care starting at the time of birth showed better oral health with less premature loss of deciduous teeth and lower need for orthodontic treatment at the age of 8  years.Trial registrationGerman Clinical Trials Register DRKS00003438,https://drks-neu.uniklinik-freiburg.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00003438 (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - May 7, 2020 Category: Dentistry Source Type: research