Gingival bleeding as a predictor of handgrip strength —an observational study and a pilot randomized clinical trial
ConclusionTaken together, our findings suggest that gingival bleeding could act as a predictor of handgrip strength and its improvement after non-surgical periodontal therapy.Clinical relevanceGingival bleeding, either as self-perceived or clinically detected, may impact handgrip strength, an important marker of muscle frailty and mortality. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - January 23, 2024 Category: Dentistry Source Type: research

Salivary Th17 cytokine, human β-defensin 1–3, and salivary scavenger and agglutinin levels in Crohn’s disease
ConclusionsCrohn ’s disease does not relate to salivary antimicrobial hBD 1–3 or SALSA levels. While Crohn’s disease patients have higher salivary Th17 cytokine levels in comparison to systemically healthy controls, an independent association between Crohn’s disease and Th17 cytokine profile is still missing .Clinical relevanceDiminished Th17 cytokine response in Crohn ’s disease, which might be related to genetic susceptibility, can be also visualized in saliva. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - January 22, 2024 Category: Dentistry Source Type: research

Genetic causal association between rheumatoid arthritis and periodontitis: a bidirectional two-sample Mendelian randomization analysis
ConclusionThis study revealed that there was a genetic causal effect of seropositive RA on PD, suggesting that this subtype of RA patients may require specific clinical attention to prevent the development of PD. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - January 20, 2024 Category: Dentistry Source Type: research

Molar incisor hypomineralization and oral health-related quality of life: a sample of 8 –12-years-old children
ConclusionsAmong the children with MIH, the OHRQoL was found to be negatively affected. The teeth with the MIH tend to reveal more tooth sensitivity than healthy teeth. Many conditions such as having MIH, and tooth sensitivity might have an impact on the OHRQoL. In addition, more sensitivity to the stimulus was observed in the teeth with lower tooth maturity status; the dental age and dental maturity might have effects on tooth sensitivity.Clinical relevanceConsidering the negative impacts due to MIH, the evaluation of OHRQoL is critical for dentists to employ a well-defined guide in their clinical decisions. (Source: Clin...
Source: Clinical Oral Investigations - January 20, 2024 Category: Dentistry Source Type: research

Effect of the use of bromelain associated with bioactive glass-ceramic on dentin/adhesive interface
ConclusionsBromelain associated with Biosilicate did not affect the BS to SD. In CAD, Br5%Bio decreased immediate BS but had no long-term influence. This association decreased the proteolytic activity.Clinical relevanceBromelain and Biosilicate  may enhance the longevity of adhesive restorations by inhibiting endogenous proteases. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - January 20, 2024 Category: Dentistry Source Type: research

Clinical performance of a glass-hybrid system in comparison with a resin composite in two-surface class II restorations: a 5-year randomised multi-centre study
ConclusionsIn terms of success and survival rates, both the glass-hybrid restorative system and the nano-hybrid resin composite have been shown to perform satisfactorily.Clinical relevanceThe results of this study indicate that EQUIA Forte can be one of the therapeutic options for moderate to large two-surface class II restorations of posterior teeth. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - January 20, 2024 Category: Dentistry Source Type: research

Salivary metabolomics in patients with oral lichen planus: a preliminary study based on NMR spectroscopy
ConclusionsSalivary tyrosine was of particular interest and a promising finding for the screening of OLP and its progression. Further longitudinal studies are required to establish it as a reliable salivary biomarker in OLP.Clinical relevanceThe salivary metabolic profiling can describe the pathologic characteristics of OLP on non-invasive saliva samples and NMR analysis. Salivary metabolites provide details to considered early detectors and to impact oral health of OLP patients. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - January 18, 2024 Category: Dentistry Source Type: research

The assessment of halitosis with a new screening tool in medication-related osteonecrosis of the jaw
ConclusionsQuantifying the level of halitosis can be used to screen for MRONJ in patients taking bisphosphonates, such as patients with osteoporosis, prostate cancer, and breast cancer.Clinical RelevanceMRONJ is accompanied by bad breath, and the concentrations of hydrogen sulfide and methyl mercaptan are associated with MRONJ. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - January 17, 2024 Category: Dentistry Source Type: research

Facts and trends in dental antibiotic and analgesic prescriptions in Germany, 2012 –2021
ConclusionsSince 2013, the most frequently prescribed antibiotic by German dentists has been amoxicillin reaching nearly half of all dental antibiotic prescriptions in 2021. Simultaneously, the proportion of clindamycin has steadily decreased, but the level is still high compared to international data. During the past decade, ibuprofen as a first-line analgesic in German dentistry was continuously gaining in importance.Clinical relevanceAminopenicillins have the best risk –benefit balance in dentistry, but the use of antibiotics generally must be limited only to cases of severe infections or compromised patients. Pre-exi...
Source: Clinical Oral Investigations - January 17, 2024 Category: Dentistry Source Type: research

Interdental papilla reconstruction: a systematic review
ConclusionThere are various options for interdental papilla reconstruction of which hyaluronic acid injections, PRF, surgical grafting and orthodontics seem to improve outcomes at a minimum 3  months. The use of soft tissue grafting with sub-epithelial connective tissue graft seems to be associated with the most robust evidence for the longer-term reduction of ‘black triangles’. There is insufficient evidence to make recommendations to clinicians. Further research is needed in the f orm of well conducted RCTs with longer follow ups and patient reported outcome measures.Clinical relevancePatients frequently complain ab...
Source: Clinical Oral Investigations - January 17, 2024 Category: Dentistry Source Type: research

Platelet-rich fibrin for rehydration and pre-vascularization of an acellular, collagen membrane of porcine origin
ConclusionsRehydration with liquid PRF of the collagen membrane results in acidity compared to a saline solution or patient ’s blood. The significant pro-angiogenic potential of the membrane alone resulted in enhanced neo-vessel formation that could not be optimized with the addition of PRF.Clinical relevance statementUsing injectable PRF for rehydration protocol of the collagen membrane leads to acidosis that can ultimately optimize wound healing. Differences in the physio-mechanical interplay of collagen matrices and autologous platelet concentrates must result in clinical algorithms if pre-vascularization can maximize...
Source: Clinical Oral Investigations - January 16, 2024 Category: Dentistry Source Type: research

Salivary metabolomics in oral potentially malignant disorders and oral cancer patients —a systematic review with meta-analysis
ConclusionEvidence for N-acetylglucosamine as a salivary biomarker for oral cancer is lacking. Although several salivary metabolites show changes between healthy, OPMDs, and OC, their diagnostic potential cannot be assessed in this review due to a lack of data. Therefore, further high-quality studies with detailed analysis and reporting are required to establish the diagnostic potential of the salivary metabolites in OPMDs and OC.Clinical relevanceWhile some salivary metabolites exhibit significant changes in oral potentially malignant  disorders (OPMDs) and oral cancer (OC) compared to healthy controls, the current evide...
Source: Clinical Oral Investigations - January 16, 2024 Category: Dentistry Source Type: research

Effect of a calcium silicate cement and experimental glass ionomer cements containing calcium orthophosphate particles on demineralized dentin
ConclusionDespite the increase in ion release, the additional Ca2+ sources did not impart remineralizing capability to GIC. Both unmodified GIC and CSC showed similar degradation in water.Clinical relevanceCSC was able to promote dentin remineralization. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - January 15, 2024 Category: Dentistry Source Type: research

Initial damage and failure load of zirconia-ceramic and metal-ceramic posterior cantilever fixed partial dentures
ConclusionsMonolithic zirconia CFPDs might be a viable alternative to completely veneered CoCr CFPDs in terms of fracture load. However, oblique loading of monolithic zirconia CFPDs should be avoided in clinical scenarios. Design improvements are required for partially veneered zirconia CFPDs to enhance their load-bearing capacity.Clinical relevanceMonolithic zirconia may represent a viable all-ceramic alternative to the established metal-ceramic option for CFPD fabrication. However, in daily clinical practice, careful occlusal adjustment and regular monitoring should ensure that oblique loading of the cantilever is avoide...
Source: Clinical Oral Investigations - January 15, 2024 Category: Dentistry Source Type: research

Comparison of the accuracy of three interproximal reduction methods used in clear aligner treatment
ConclusionsThe overall accuracy of the 2 motor-driven IPR methods was found to be better than the hand-operated system. Maxillary central incisors and mandibular canines were more prone to IPR deficiency when hand-operated abrasive strips were utilized. Patients were similarly comfortable with all 3 methods, and discomfort and anxiety levels decreased with age.Clinical relevanceMotor-driven methods have proven to be more effective when compared to the hand-operated ones by means of precision, speed, and patient comfort. If the clinician favors a hand-operated method, it may be advised to perform slightly more IPR especiall...
Source: Clinical Oral Investigations - January 15, 2024 Category: Dentistry Source Type: research