A German version of the Oral Impacts of Daily Performances —reliability and validity
ConclusionsThe German version of the OIDP demonstrated sufficient reliability and validity. OIDP ’s general performance should be interpreted cautiously as the outcome was detected in a specifically healthy population.Clinical relevanceThe OIDP is yet the only dPROM that evaluates both severity as well as frequency which makes validation interesting regarding specific target populations. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - January 4, 2024 Category: Dentistry Source Type: research
Alveolar ridge splitting and simvastatin loaded xenograft for guided bone regeneration and simultaneous implant placement: randomized controlled clinical trial
ConclusionAlveolar ridge splitting along with GBR-augmented SMV improve the clinical and radiographical outcomes around dental implant over GBR alone.Clinical relevanceAugmenting GBR with SMV in alveolar ridge splitting could boost implant osseointegration and enhance peri-implant tissue changes.Clinical trial registration: NCT05020405. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - January 4, 2024 Category: Dentistry Source Type: research
In vitro and in vivo evaluation of iRoot BP Plus as a coronal sealing material for regenerative endodontic procedures
ConclusionsiRoot BP Plus showed excellent sealing ability, promoted the migration and osteo/odontogenesis of SCAP and induced pulp-dentin complex formation without affecting the cell proliferation, which indicated iRoot BP Plus was a promising coronal sealing material in REPs.Clinical relevanceThe coronal sealing materials play crucial roles for the outcomes of REPs. This study showed that iRoot BP Plus has good coronal sealing and promote pulp-dentin complex formation compared with MTA, providing experimental evidences for the clinical application of iRoot BP Plus as a promising coronal seal material in REPs. (Source: Cli...
Source: Clinical Oral Investigations - January 3, 2024 Category: Dentistry Source Type: research
The prophylactic effect of photobiomodulation therapy on pain perception due to infiltration injection: a randomized clinical trial
ConclusionsThe study showed a significant effect of photobiomodulation on reducing pain perception during infiltration injection.Clinical relevanceThis method can be useful in order to lower the pain for the patients consulting a dentist and therefore facilitate consulting at early stages of the dental issues.Trial registrationThe registration number (date) of the clinical trial in a Primary Registry in the WHO Registry Network is IR.ARAKMU.REC.1398.248(13/03/2020). The related URL ishttps://en.irct.ir/trial/45362. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - January 3, 2024 Category: Dentistry Source Type: research
Enhanced antimicrobial efficacy of chlorhexidine-encapsulated halloysite nanotubes incorporated in presurgical orthopedic appliances: an in vitro, controlled study
ConclusionIncorporating CHX-HNTs in PMMA successfully enhanced its antimicrobial properties, providing sustained CHX release and superior antimicrobial efficacy. These findings demonstrate the potential of antimicrobial nanoparticles in dental therapies to improve therapeutic outcomes. However, rigorous further clinical trials and observational studies are warranted to validate the practical application, safety, and efficacy.Clinical relevanceThis study has the potential to make a major impact on the health of infants born with cleft lip and palate by helping to reduce the prevalence of infectious illnesses. The incorporat...
Source: Clinical Oral Investigations - January 2, 2024 Category: Dentistry Source Type: research
Deciphering genomic signatures associating human dental oral craniofacial diseases with cardiovascular diseases using machine learning approaches
ConclusionsCVDs are relatively common in patients with periodontal disease, and an increased risk of CVD is associated with periodontal disease independent of gender. Genetic susceptibility contributing to periodontitis and CVDs have been suggested to some extent, based on the similar degree of heritability shared between both complex diseases. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - January 1, 2024 Category: Dentistry Source Type: research
Effects of sagittal split Ramus osteotomy on condylar position and Ramal orientation in patients with mandibular asymmetry
ConclusionsSSRO has inevitable effects on the condylar and ramal orientation. Individuals with asymmetry require particular attention throughout the planning process and beyond. Conjunctive modalities and modifications should be considered and utilized when necessary. Future studies with larger sample sizes, homogenous follow-up periods, and more comprehensive clinical data are needed to substantiate understanding of the response of the condylar segment.Clinical relevanceOrthognathic surgeries inevitably alter the alignment and harmony of temporomandibular structures and may result in change of AJS, PJS, SJS, CAA, SRA, and...
Source: Clinical Oral Investigations - December 30, 2023 Category: Dentistry Source Type: research
Methodological quality of evidence-based clinical practice guidelines in cariology
ConclusionThe overall methodological quality of evidence-based CPGs in the cariology field is moderate, and there is a need for improvements in reporting related to most domains. The poorest reporting was found in the description of the domains ’ applicability of its recommendations and editorial independence.Clinical relevanceClinical Practice Guidelines provide guidance to patients, healthcare professionals, and stakeholders. The quality of these documents is essential for establishing trust in their recommendations. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - December 30, 2023 Category: Dentistry Source Type: research
Investigating the potential clinical impact of periodontitis on the progression of Alzheimer ’s disease: a prospective cohort study
ConclusionsWithin the limits of our study, it can be concluded that periodontitis may increase the severity and also accelerate the progression rate of AD.Clinical relevanceThese results are precious to show the necessity of proper oral hygiene activities and regular dental visits in patients with toothed AD.Clinical trial registrationThis study was registered and approved by clinical trials (NCT05807100). (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - December 30, 2023 Category: Dentistry Source Type: research
Exploring the Role of Wnt Ligands in Osteogenic Differentiation of Human Periodontal Ligament Stem Cells
ConclusionWnt ligands, particularly WNT3A and WNT4, play an important role in hPDLSCs' osteogenic differentiation, highlighting their potential as promoters of osteogenesis.Clinical Relevance.Given the challenging nature of alveolar bone regeneration, therapeutic strategies that target WNT3A and WNT4 signaling pathways offer promising opportunities. Additionally, innovative gene therapy approaches aimed at regulating of WNT3A and WNT4 expression hold potential for improving alveolar bone regeneration outcomes. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - December 30, 2023 Category: Dentistry Source Type: research
Evaluation of safe areas for miniscrew use according to various skeletal anomalies with CBCT
ConclusionsWe observed significant differences in the buccal cortical bone thickness, interradicular bone distance, and buccolingual bone distance among individuals.Clinical relevanceUnderstanding the anatomy of interradicular regions and preventing complications. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - December 30, 2023 Category: Dentistry Source Type: research
Global prevalence of human papillomavirus-related oral and oropharyngeal squamous cell carcinomas: a systematic review and meta-analysis
ConclusionThe evidence points to an apparent burden in HPV-related OPSCC, mostly in North America, Northern Europe, and Oceania, especially due to the HPV16 infection suggesting different trends across continents.Clinical relevanceThis updated systematic review and meta-analysis provide sufficient evidence about the global HPV prevalence in OSCC and OPSCC and the most frequent HPV subtype worldwide. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - December 30, 2023 Category: Dentistry Source Type: research
Identification of novel candidate genes associated with non-syndromic tooth agenesis in Mongolian families
ConclusionsThe study identified various genetic variant candidates associated with TA in different family groups, with PITX2 being the most commonly identified. Our findings suggest that MAST4 may also be a novel candidate gene for TA due to its association with the Wnt signaling pathway. Additionally, we found that five candidate genes related to focal adhesion and calcium channel complex were significant and essential in tooth development.Clinical relevanceIdentifying new pathogenic genes associated with TA can improve our understanding of the molecular mechanisms underlying the disease, leading to better diagnosis, prev...
Source: Clinical Oral Investigations - December 29, 2023 Category: Dentistry Source Type: research
Speech correcting surgery after primary palatoplasty: a systematic literature review and meta-analysis
ConclusionsA lower SCS rate was found in patients receiving Z-palatoplasty when compared to straight-line palatoplasty. We propose a minimum set of outcome parameters which ideally should be included in future studies regarding speech outcomes after cleft palate repair.Clinical relevanceCurrent literature reports highly heterogenous data regarding cleft palate repair. Our recommended set of parameters may address this inconsistency and could make intercenter comparison possible and of better quality. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - December 29, 2023 Category: Dentistry Source Type: research
Clinical, oral immunological and microbiological shifts during and after pregnancy
ConclusionsThis study identified a significantly increased Th1/Th2 cytokine ratio during pregnancy and a positive association with putative periodontal pathogens. This immunological and microbiological deregulation in the oral milieu during pregnancy is suggestive of a destructive inflammatory periodontal profile.Study registrationClinical Trials.gov (Record BAP-2015).Clinical relevanceUnderstanding altered oral immunological and microbiological regulation patterns during pregnancy may help improve the inflammatory periodontal profile in pregnant women. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - December 29, 2023 Category: Dentistry Source Type: research
