Multi-omics analysis of immune-related microbiome and prognostic model in head and neck squamous cell carcinoma

ConclusionsThis study offers a comprehensive exploration of the ICI landscape in HNSCC. We provide a detailed scenario of immune regulation in HNSCC and report a correlation between differing ICI patterns, intratumor microbiome, and prognosis. This research aids in identifying prime candidates for optimizing treatment strategies in HNSCC.Clinical relevanceThis study revealed the microbial signatures associated with immunophenotyping of HNSCC and further found the microbial signatures associated with prognosis. The prognostic model based on IRM microbes is helpful for early prediction of patient prognosis and assisting clinical decision-making.
Source: Clinical Oral Investigations - Category: Dentistry Source Type: research