Improved all-cause mortality with left bundle branch area pacing compared to biventricular pacing in cardiac resynchronization therapy: a meta-analysis
ConclusionIn this meta-analysis, LBBAP was associated with a significant reduction in all-cause mortality as well as HF-related hospitalization when compared to BIVP. Additional data from large RCTs is warranted to corroborate these promising findings.Graphical abstractLBBP, left bundle branch area pacing; BIVP, biventricular pacing; RRR, relative risk reduction; ARR, absolute risk reduction; ms, milliseconds; LVEF, left ventricular ejection fraction; NYHA, New York Heart Association; min, minutes (Source: Journal of Interventional Cardiac Electrophysiology)
Source: Journal of Interventional Cardiac Electrophysiology - April 26, 2024 Category: Cardiology Source Type: research
Alcohol consumption and progression of heart failure in those at risk for or with pre-heart failure
People with heart risk factors such as high blood pressure, diabetes, obesity or high cholesterol, may develop extra strain on the heart over time because of these risk factors. We researched the association of low and moderate-high levels of alcohol intake, compared to no intake, with changes in the heart over time. We found that amongst participants with heart abnormalities, drinking the equivalent of more than a bottle of wine per week was associated with further negative changes in the heart or development of symptoms of heart failure. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - April 26, 2024 Category: Cardiology Authors: Bethany Wong, Ashe Moore, Ken McDonald, Mark Ledwidge Source Type: research
Effect of diabetes mellitus on global longitudinal strain
The global longitudinal strain (GLS) of the left ventricle (LV) is considered an effective measure for the evaluation of ventricular function, especially in the absence of systolic dysfunction or in its earliest forms, and it correlates strongly with LV ejection fraction (LVEF) (1 –3). Age, gender, and impaired LVEF have been identified as leading factors for higher GLS(2). Patients with diabetes mellitus (DM) have a higher risk of developing ventricular dysfunction and heart failure (HF)(4). We hypothesized that DM could be have a higher impact on GLS in patients with HF. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - April 26, 2024 Category: Cardiology Authors: Alberto Cordero, David Sirera, Jos é Méndez-Gallego, Ignacio Echeverría Tags: Brief report Source Type: research
Metabolite identification of salvianolic acid A in rat using post collision-induced dissociation energy-resolved mass spectrometry
As one of the most famous natural products, salvianolic acid A (SAA) is undergoing clinical trials for the treatments of angina pectoris and coronary heart disorders. However, the in vivo metabolites of SAA ha... (Source: Chinese Medicine)
Source: Chinese Medicine - April 26, 2024 Category: Complementary Medicine Authors: Han Li, Ke Zhang, Wei Chen, Yuxuan Zhou, Jun Li, Yunfang Zhao and Yuelin Song Tags: Research Source Type: research
Climbers at High Altitudes at Risk of Heart Rhythm Abnormalities
More than one-third of climbers who were exposed to the low-pressure and low-oxygen environment of Mount Everest experienced a cardiac arrhythmia during their climb, a small study found. The data came from 41 healthy men who were, on average, in their mid-30s. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 26, 2024 Category: General Medicine Source Type: research
Could a rare mutation that causes dwarfism also slow ageing?
Nature, Published online: 26 April 2024; doi:10.1038/d41586-024-01201-6People with Laron syndrome have a low risk of heart disease and a number of other age-related disorders, hinting at strategies for new treatments. (Source: Nature AOP)
Source: Nature AOP - April 26, 2024 Category: Research Authors: Mariana Lenharo Source Type: research
Trimethylamine-N-Oxide and Related Metabolites: Assessing Cardiovascular Risk in the Dallas Heart Study
To evaluate the association between trimethylamine N-oxide (TMAO) and related metabolites with adverse cardiovascular events in a multiethnic urban primary prevention population. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - April 26, 2024 Category: Internal Medicine Authors: Yeela Talmor-Barkan, Jiao Yu, Nancy-Sarah Yacovzada, Nili Schamroth Pravda, Colby Ayers, James A. de Lemos, W.H.Wilson Tang, Stanley L. Hazen, Alon Eisen, Guy Witberg, Ran Kornowski, Ian J. Neeland Tags: Original article Source Type: research
Audio long read: Why loneliness is bad for your health
Nature, Published online: 26 April 2024; doi:10.1038/d41586-024-01251-wNew research is revealing the mechanisms linking loneliness and conditions like dementia, depression and cardiovascular disease. (Source: Nature AOP)
Source: Nature AOP - April 26, 2024 Category: Research Authors: Saima May Sidik Benjamin Thompson Source Type: research
Treat-to-target or treat-to-dissolve strategy to improve gout treatment
Nature Reviews Rheumatology, Published online: 26 April 2024; doi:10.1038/s41584-024-01117-5Medication adherence in gout is low, and discontinuation of urate-lowering therapy puts patients at risk of flares and cardiovascular events. A strategy to regularly monitor serum urate levels and the dissolution of urate deposits (particularly if visualized by patients) might encourage adherence in the long term. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - April 26, 2024 Category: Rheumatology Authors: Pascal Richette Nicola Dalbeth Source Type: research
Applications of SGLT2 inhibitors beyond glycaemic control
Nature Reviews Nephrology, Published online: 26 April 2024; doi:10.1038/s41581-024-00836-yHere, the authors discuss the beneficial effects of sodium–glucose cotransporter 2 (SGLT2) inhibitors for a range of clinical outcomes beyond glucose lowering, including kidney and cardiovascular protection. They also discuss the need for implementation and adherence initiatives to help translate the benefits of these agents into real-world clinical outcomes. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 26, 2024 Category: Urology & Nephrology Authors: Daniel V. O ’Hara Carolyn S. P. Lam John J. V. McMurray Tae Won Yi Samantha Hocking Jessica Dawson Smriti Raichand Andrzej S. Januszewski Meg J. Jardine Source Type: research
Molecules, Vol. 29, Pages 2005: Potential Targets of Natural Products for Improving Cardiac Ischemic Injury: The Role of Nrf2 Signaling Transduction
Zhang
Myocardial ischemia is the leading cause of health loss from cardiovascular disease worldwide. Myocardial ischemia and hypoxia during exercise trigger the risk of sudden exercise death which, in severe cases, will further lead to myocardial infarction. The Nrf2 transcription factor is an important antioxidant regulator that is extensively engaged in biological processes such as oxidative stress, inflammatory response, apoptosis, and mitochondrial malfunction. It has a significant role in the prevention and treatment of several cardiovascular illnesses, since it can control not only the expression of several an...
Source: Molecules - April 26, 2024 Category: Chemistry Authors: Wang Han Dmitrii Zhang Tags: Review Source Type: research
Molecules, Vol. 29, Pages 2007: Pharmacological Potential of Kaempferol, a Flavonoid in the Management of Pathogenesis via Modulation of Inflammation and Other Biological Activities
udi
Rahmani
Natural products and their bioactive compounds have been used for centuries to prevent and treat numerous diseases. Kaempferol, a flavonoid found in vegetables, fruits, and spices, is recognized for its various beneficial properties, including its antioxidant and anti-inflammatory potential. This molecule has been identified as a potential means of managing different pathogenesis due to its capability to manage various biological activities. Moreover, this compound has a wide range of health-promoting benefits, such as cardioprotective, neuroprotective, hepatoprotective, and anti-diabetic, and has a role...
Source: Molecules - April 26, 2024 Category: Chemistry Authors: Alrumaihi Almatroodi Alharbi Alwanian Alharbi Almatroudi Rahmani Tags: Review Source Type: research
IJERPH, Vol. 21, Pages 549: Wrist Circumference Cutoff Points for Determining Excess Weight Levels and Predicting Cardiometabolic Risk in Adults
Conclusions: Wrist circumference showed a significant correlation with other adiposity indicators and can be used to identify adults with excess weight and predict cardiometabolic risk. (Source: International Journal of Environmental Research and Public Health)
Source: International Journal of Environmental Research and Public Health - April 26, 2024 Category: Environmental Health Authors: Larissa Monteiro Costa Pereira M árcia Ferreira Cândido de Souza Felipe J. Aidar M árcio Getirana-Mota Alex Menezes dos Santos-Junior Mario Francisco Dantas de Santana Filho Marcos Antonio Almeida-Santos Raysa Manuelle Santos Rocha Rebeca Rocha de Alme Tags: Article Source Type: research
Effect of acute high-intensity interval exercise on a mouse model of doxorubicin-induced cardiotoxicity: a pilot study
ConclusionsIn this pilot murine study, one single HIIE session did not exacerbate acute doxorubicin-induced cardiotoxicity. The timing of the HIIE session following DOX injection and the level of compliance to exercise could influence the negative impact of DOX on cardiac function. (Source: BMC Sports Science, Medicine and Rehabilitation)
Source: BMC Sports Science, Medicine and Rehabilitation - April 26, 2024 Category: Sports Medicine Source Type: research
Response to: The Synergism of Public Health Policies and Social Work May Reduce Mortality from Cancer, Liver Disease and Cardiovascular Disease
We appreciate the interest that emerged from our recent publication [1], ‘Association between public health policies on alcohol and worldwide cancer, liver disease, and cardiovascular disease outcomes’ [2]. In our research, we evidenced a strong relationship between alcohol-related public health policies (PHP) establishment and the decrease of alcohol-related health consequences over time among 169 countries, including liver disease and other significant causes of burden of disease worldwide. These associations were stronger over time, and consistent with the framework SAFER proposed by the World Health Organization (W...
Source: Journal of Hepatology - April 26, 2024 Category: Gastroenterology Authors: Luis Antonio D íaz, Eduardo Fuentes-López, Juan Pablo Arab Tags: Letter to the Editor Source Type: research
