High Baseline High-Sensitivity Cardiac Troponin T Concentrations and Risk of Index Acute Myocardial Infarction
To evaluate the diagnostic performance of the previously recommended baseline high-sensitivity cardiac troponin T (hs-cTnT) thresholds of 52 and 100 ng/L in identifying patients at high risk of acute myocardial infarction (AMI). (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - March 16, 2024 Category: Internal Medicine Authors: Jonathan D. Knott, Olatunde Ola, Laura De Michieli, Ashok Akula, Eric H. Yang, S. Michael Gharacholou, Josh Slusser, Bradley Lewis, Ramila A. Mehta, Rajiv Gulati, Yader Sandoval, Allan S. Jaffe Tags: Original article Source Type: research
Outcomes of Acute Respiratory Failure in Patients With Cancer in the United States
To determine the epidemiological effect-magnitude and outcomes of patients with cancer vs those without cancer who are hospitalized with acute respiratory failure (ARF). (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - March 7, 2024 Category: Internal Medicine Authors: Kiyan Heybati, Jiawen Deng, Archis Bhandarkar, Fangwen Zhou, Cameron Zamanian, Namrata Arya, Mohamad Bydon, Philippe R. Bauer, Ognjen Gajic, Allan J. Walkey, Hemang Yadav Tags: Original Article Source Type: research
Congenital Absence of Right Coronary Artery
A White male in his 20s with no past medical history presented with sudden symptoms of shortness of breath, nausea, and vomiting while at work. He also had a fever, cough, and tested positive for cannabis and tetrahydrocannabinol. On admission, he showed sinus tachycardia at 150 beats/min and low blood pressure (112/52 mm Hg). Laboratory tests revealed abnormal results, including elevated white blood cell count (24 ×109/L [reference range, (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - March 7, 2024 Category: Internal Medicine Authors: Shriya Sharma, Elizabeth Johnson, Rohan Goswami Tags: Medical image Source Type: research
Circle of Willis
A man in his 50s with a history of squamous cell carcinoma of the tongue with cervical lymph node involvement after radiotherapy presented to an ophthalmologist with intermittent visual changes. His neurologic examination yielded normal results. Fundoscopy revealed cotton wool spots bilaterally, concerning for ischemic retinopathy. Computed tomographic angiography of the neck revealed chronic complete occlusions of the bilateral common carotid arteries and the left vertebral artery. Magnetic resonance imaging of the brain showed multiple bihemispheric watershed infarcts. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - March 7, 2024 Category: Internal Medicine Authors: Nitesh P. Patel, Lorenzo Rinaldo, Giuseppe Lanzino Tags: Medical image Source Type: research
Emulated Trial for Discharge Prescription of Guideline-Directed Medical Therapy and 15-Year Survival After Coronary Artery Bypass Graft Surgery
To explore admission and discharge prescription rates of guideline-directed medical therapy (GDMT), defined as aggregate antiplatelet agents, statins, and β-blockers, after coronary artery bypass graft (CABG) surgery and to reveal its association with long-term survival. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - March 6, 2024 Category: Internal Medicine Authors: Yaron Moshkovitz, Liat Orenstein, Liraz Olmer, Keren Laufer, Arnona Ziv, Rachel Dankner Tags: Original article Source Type: research
Academic Promotions in Medicine: An Appraisal of Fairness
To investigate whether the process of conferring academic rank or components of the promotion packet contribute to the lack of parity in academic advancement for women and individuals underrepresented in medicine (URMs). (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - March 1, 2024 Category: Internal Medicine Authors: Rahma Warsame, Yong-hun Kim, Melody Y. Ouk, Kristin C. Mara, Martha Q. Lacy, Sharonne N. Hayes, Zamzam Shalle, Joyce Balls-Berry, Barbara L. Jordan, Felicity T. Enders, Alexandra P. Wolanskyj-Spinner, Robert J. Spinner Tags: Original article Source Type: research
Building Capacity for Pragmatic Trials of Digital Technology in Primary Care
Frontline primary care teams face important challenges in seeking to transform the quality of care delivered to patients and to reduce clerical burden for clinicians. Digital technologies using artificial intelligence hold substantial promise to aid in this transformation. Both pragmatic clinical trials and implementation science are key tools to successfully introduce, evaluate, and sustain innovations in real-world primary care practices. Previous articles in this thematic series have provided an in-depth overview of pragmatic trials and implementation science. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - March 1, 2024 Category: Internal Medicine Authors: David R. Rushlow, Thomas D. Thacher, Barbara A. Barry Tags: Thematic review on forward thinking on clinical trials in clinical practice Source Type: research
Chronic Granulomatous Disease Presenting With Recurrent Skin Infections
A man in his early 20s presented with a 5-year history of nonhealing skin lesions, initially developing as clustered erythematous bullae forming ulcerated and impetiginized serum-crusted lesions, spread diffusely across his body at various stages of healing but sparing the palms, soles, and oral mucosa (Figures 1A and 2A). Skin biopsy revealed dermal neutrophilic inflammation, and tissue cultures isolated Staphylococcus aureus. Neutrophil function testing revealed a moderate decrease in dihydrorhodamine-positive cells and profoundly decreased mean fluorescence intensity following stimulation with phorbol -12-myristate 13...
Source: Mayo Clinic Proceedings - March 1, 2024 Category: Internal Medicine Authors: Ryan B. Khodadadi, Zachary A. Yetmar, Carmen M. Montagnon Tags: Medical image Source Type: research
Acitretin Treatment Improves a Case of Severe Generalized Epidermodysplasia Verruciformis
A man in his 20s had a 15-year history of generalized hyperkeratotic wart –like plaques. Small warty papules appeared first on his hands in childhood and gradually spread over his body, merging into many large hyperkeratotic plaques and ridges during several years (Supplemental Figure 1, available online at http://www.mayoclinicproceedings.org). The fingernails and toe nails took on a coral or dendritic shape (Figure 1). Hand and foot function and quality of life were significantly impaired. The remainder of his family has no history of similar conditions. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - March 1, 2024 Category: Internal Medicine Authors: Jun-Cheng Liu, Si-Tan Dong, Dong-Mei Shi Tags: Medical image Source Type: research
Evolution and Prognostic Significance of Patient-Reported Symptoms After Intervention in Severe Aortic Stenosis
To describe the evolution of symptoms in patients with symptomatic severe aortic stenosis (sSAS) undergoing valve replacement, the predictors of the persistence of these symptoms, and their prognostic significance. The evolution of symptoms after intervention in sSAS and their association with outcome are unknown. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - March 1, 2024 Category: Internal Medicine Authors: J. Alberto San Rom án, Cristina Ybarra-Falcón, Mario García-Gómez, Noemí Ramos, Luis Nombela, Manuel Carnero, Ignacio J. Amat-Santos, Teresa Sevilla, Ana Revilla, Manuel Carrasco, Javier López-Díaz, Isidre Vilacosta Tags: Original article Source Type: research
Adrenal Hemorrhage: A Comprehensive Analysis of a Heterogeneous Entity —Etiology, Presentation, Management, and Outcomes
To investigate the etiology, presentation, management, and outcomes of patients with adrenal hemorrhage (AH). (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - March 1, 2024 Category: Internal Medicine Authors: Prerna Dogra, Mrunal Chinthapalli, Rashi Sandooja, Leili Rahimi, Nicole M. Iniguez-Ariza, Trenton Foster, Irina Bancos Tags: Original article Source Type: research
A Giant Subacute Aortic Valve Thrombus
A woman in her 50s with hypertension was admitted to the hospital for hypokinetic cardiomyopathy workup. Transthoracic echocardiography (TTE) and magnetic resonance imaging showed left ventricular function at 30%; coronary angiogram was normal. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - March 1, 2024 Category: Internal Medicine Authors: Mariama Akodad, Philippe Rouviere, Richard Gervasoni Tags: Medical image Source Type: research
Oncocytic Poorly Differentiated Thyroid Carcinoma
A woman in her 60s with a history of thyroid cancer presented with a neck mass. The resection revealed a nonanaplastic oncocytic thyroid carcinoma invading the skin with increased mitotic activity and loss of the follicular growth pattern (Figure). The immunophenotype supported thyroidal origin. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - March 1, 2024 Category: Internal Medicine Authors: Rumeal D. Whaley, Sounak Gupta, Lori A. Erickson Tags: Path to patient image quiz Source Type: research
The Importance of Estimating Excess Deaths Regionally During the COVID-19 Pandemic
National or statewide estimates of excess deaths have limited value to understanding the impact of the COVID-19 pandemic regionally. We assessed excess deaths in a 9-county geographically defined population that had low rates of COVID-19 and widescale availability of testing early in the pandemic, well-annotated clinical data, and coverage by 2 medical examiner ’s offices. We compared mortality rates (MRs) per 100,000 person-years in 2020 and 2021 with those in the 2019 reference period and MR ratios (MRRs). (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - March 1, 2024 Category: Internal Medicine Authors: Suzette J. Bielinski, Sheila M. Manemann, Guilherme S. Lopes, Ruoxiang Jiang, Susan A. Weston, R. Ross Reichard, Aaron D. Norman, Celine M. Vachon, Paul Y. Takahashi, Mandeep Singh, Nicholas B. Larson, V éronique L. Roger, Jennifer L. St. Sauver Tags: Brief report Source Type: research
Management of Patients With Kidney Disease Undergoing Bariatric Surgery
Bariatric surgery is increasingly recognized as a safe and effective treatment for obesity in patients with chronic kidney disease (CKD), including stages 4, 5, and 5D (on dialysis). Among the available surgical methods, sleeve gastrectomy (SG) is the most commonly performed weight loss procedure and is mainly done to facilitate kidney transplantation (KT). However, many KT candidates treated with SG remain on the transplant waiting list for months to years, with some never receiving a transplant. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - March 1, 2024 Category: Internal Medicine Authors: Aleksandra Kukla, Yogish C. Kudva, Pavel Navratil, Sukhdeep S. Sahi, Roberto P. Benzo, David C. Fipps, Avery E. Erickson, Rachael R. Majorowicz, Matthew M. Clark, Carrie A. Schinstock, Pankaj Shah, Meera Shah, Tayyab S. Diwan Tags: Special article Source Type: research