Growth differentiation factor-15 serum concentrations reflect disease severity and anemia in patients with inflammatory bowel disease
CONCLUSION: For the first time, we demonstrated that serum concentrations of GDF-15 are elevated in patients with IBD in comparison to healthy controls, and the results imply that GDF-15 might be involved in IBD pathophysiology. Yet, it remains elusive whether GDF-15 could serve as a prognostic indicator in these patients.PMID:38659482 | PMC:PMC11036493 | DOI:10.3748/wjg.v30.i13.1899 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 25, 2024 Category: Gastroenterology Authors: Ante Tonkic Marko Kumric Ivna Akrapovic Olic Doris Rusic Piero Marin Zivkovic Daniela Supe Domic Zeljko Sundov Ivan Males Josko Bozic Source Type: research
Effect of Histamine H2 Receptor Antagonists on All-Cause Mortality in Critically Ill Patients With Essential Hypertension: A Retrospective Cohort Study
In conclusion, H2RAs exposure was related to lower mortalities in critically ill patients with essential hypertension, which provided novel potential strategy for the use of H2RAs in essential hypertension patients.PMID:38659369 | DOI:10.1002/jcph.2445 (Source: The Journal of Clinical Pharmacology)
Source: The Journal of Clinical Pharmacology - April 25, 2024 Category: Drugs & Pharmacology Authors: Jian-Mei Pan Yu Guo Fang-Fang Jiang Ran Xu Xin Zhang Wen-Ke Cai Sun-Jun Yin Ping Wang Yan-Hua Huang Xue-Sha Zhang Yi-Hua Li Liao Cai Gong-Hao He Source Type: research
Association between Atherosclerosis and High-Risk Colorectal Adenomas based on Cardio-Ankle Vascular Index and Ankle-Brachial Index
CONCLUSIONS: In this study, a significant correlation between positive CAVI and high-risk adenomas was observed. Therefore, CAVI may be a significant predictor for high-risk colorectal adenoma.PMID:38659250 | DOI:10.4166/kjg.2024.003 (Source: Korean J Gastroenter...)
Source: Korean J Gastroenter... - April 25, 2024 Category: Gastroenterology Authors: Jung Ho Lee Hyunseok Cho Sang Hoon Lee Sung Joon Lee Chang Don Kang Dae Hee Choi Jin Myung Park Seung-Joo Nam Tae Suk Kim Ji Hyun Kim Sung Chul Park Source Type: research
Differential Impact In Vivo of Pf4- ΔCre-Mediated and Gp1ba-ΔCre-Mediated Depletion of Cyclooxygenase-1 in Platelets in Mice
CONCLUSIONS: Both approaches to Cox-1 deletion similarly restrain thrombogenesis, but a differential impact on Cox-1-dependent prostanoid formation by the vasculature may contribute to an inflammatory phenotype and accelerated atherogenesis in Pf4-ΔCre mice.PMID:38660804 | DOI:10.1161/ATVBAHA.123.320295 (Source: Atherosclerosis)
Source: Atherosclerosis - April 25, 2024 Category: Cardiology Authors: Soon Yew Tang Ronan Lordan Hu Meng Benjamin J Auerbach Elizabeth J Hennessy Arjun Sengupta Ujjalkumar S Das Robin Joshi Oscar A Marcos-Contreras Ryan McConnell Gregory R Grant Emanuela Ricciotti Vladimir R Muzykantov Tilo Grosser Aalim M Weiljie Garret A Source Type: research
Immunoproteasomal Inhibition With ONX-0914 Attenuates Atherosclerosis and Reduces White Adipose Tissue Mass and Metabolic Syndrome in Mice
CONCLUSIONS: We propose that immunoproteasomal inhibition reduces 3 major causes underlying cardiovascular disease, dyslipidemia, metabolic syndrome, and inflammation and is a new target in drug development for atherosclerosis treatment.PMID:38660806 | DOI:10.1161/ATVBAHA.123.319701 (Source: Atherosclerosis)
Source: Atherosclerosis - April 25, 2024 Category: Cardiology Authors: Frank H Schaftenaar Andrea D van Dam Gerjan de Bruin Marie A C Depuydt Jill de Mol Jacob Amersfoort Hidde Douna Menno Meijer Mara J Kr öner Peter J van Santbrink Mireia N A Bernab é Kleijn Gijs H M van Puijvelde Bogdan I Florea Bram Sl ütter Amanda C F Source Type: research
Immunoproteasomal Inhibition With ONX-0914 Attenuates Atherosclerosis and Reduces White Adipose Tissue Mass and Metabolic Syndrome in Mice
CONCLUSIONS: We propose that immunoproteasomal inhibition reduces 3 major causes underlying cardiovascular disease, dyslipidemia, metabolic syndrome, and inflammation and is a new target in drug development for atherosclerosis treatment.PMID:38660806 | DOI:10.1161/ATVBAHA.123.319701 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 25, 2024 Category: Cardiology Authors: Frank H Schaftenaar Andrea D van Dam Gerjan de Bruin Marie A C Depuydt Jill de Mol Jacob Amersfoort Hidde Douna Menno Meijer Mara J Kr öner Peter J van Santbrink Mireia N A Bernab é Kleijn Gijs H M van Puijvelde Bogdan I Florea Bram Sl ütter Amanda C F Source Type: research
Interactions Between HDL and CD4+ T Cells: A Novel Understanding of HDL Anti-Inflammatory Properties
We present a model where HDL may modulate T cells through both direct and indirect mechanisms.PMID:38660807 | DOI:10.1161/ATVBAHA.124.320851 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 25, 2024 Category: Cardiology Authors: Laura Atehortua W Sean Davidson Claire A Chougnet Source Type: research
Potential Influence of Risk Factor Control on the Association Between Lipoprotein(a) and Atherosclerotic Cardiovascular Disease
Arterioscler Thromb Vasc Biol. 2024 Apr 25. doi: 10.1161/ATVBAHA.124.320990. Online ahead of print.NO ABSTRACTPMID:38660805 | DOI:10.1161/ATVBAHA.124.320990 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 25, 2024 Category: Cardiology Authors: Jonas Ghouse Gustav Ahlberg S øren Albertsen Rand Morten Salling Olesen Bjarni Vilhjalmsson Stefan Stender Henning Bundgaard Source Type: research
Differential Impact In Vivo of Pf4- ΔCre-Mediated and Gp1ba-ΔCre-Mediated Depletion of Cyclooxygenase-1 in Platelets in Mice
CONCLUSIONS: Both approaches to Cox-1 deletion similarly restrain thrombogenesis, but a differential impact on Cox-1-dependent prostanoid formation by the vasculature may contribute to an inflammatory phenotype and accelerated atherogenesis in Pf4-ΔCre mice.PMID:38660804 | DOI:10.1161/ATVBAHA.123.320295 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 25, 2024 Category: Cardiology Authors: Soon Yew Tang Ronan Lordan Hu Meng Benjamin J Auerbach Elizabeth J Hennessy Arjun Sengupta Ujjalkumar S Das Robin Joshi Oscar A Marcos-Contreras Ryan McConnell Gregory R Grant Emanuela Ricciotti Vladimir R Muzykantov Tilo Grosser Aalim M Weiljie Garret A Source Type: research
Community Health workers United to Reduce Colorectal cancer and cardiovascular disease among people at Higher risk (CHURCH): study protocol for a randomized controlled trial
Discussion: Church-placed CHWs are trusted influential connectors between communities and health systems. Studies have shown that these CHWs can successfully implement health prevention protocols in churches, including those related to cancer control, making them potentially important community mediators of CRC screening uptake and CRC/CVD risk reduction. Trial registration: NCT05174286.PMID:38659874 | PMC:PMC11042434 | DOI:10.21203/rs.3.rs-3797889/v1 (Source: Cancer Control)
Source: Cancer Control - April 25, 2024 Category: Cancer & Oncology Authors: Olajide Williams Tina Ting Lisa Matthews Gladys Block Torin Block Jeanne Teresi Joseph Eimicke Jian Kong Stephanie Silver Joseph Ravenell Janhavi Mallaiah Soujanya Jammalamadaka Laura Maudene Nelson Wahida Karmally Sidney Hankerson Source Type: research
Depleted housing elicits cardiopulmonary dysfunction after a single flaming eucalyptus wildfire smoke exposure in a sex-specific manner in ApoE knockout mice
Res Sq [Preprint]. 2024 Apr 12:rs.3.rs-4237383. doi: 10.21203/rs.3.rs-4237383/v1.ABSTRACTAlthough it is well established that wildfire smoke exposure can increase cardiovascular morbidity and mortality, the combined effects of non-chemical stressors and wildfire smoke remains understudied. Housing is a non-chemical stressor that is a major determinant of cardiovascular health, however, disparities in neighborhood and social status have exacerbated the cardiovascular health gaps within the United States. Further, pre-existing cardiovascular morbidities, such as atherosclerosis, can worsen the response to wildfire smoke expo...
Source: Atherosclerosis - April 25, 2024 Category: Cardiology Authors: Michelle Fiamingo Sydnie Toler Kaleb Lee Wendy Oshiro Todd Krantz Paul Evansky David Davies M Ian Gilmour Aimen Farraj Mehdi S Hazari Source Type: research
Effects of a Global < em > Rab27a < /em > Null Mutation on Murine PVAT and Cardiovascular Function
CONCLUSIONS: Global RAB27A loss impacted perivascular adipose tissue and thoracic aorta proteomic signatures, altered vasocontractile responses, and decreased left ventricular ejection fraction in mice.PMID:38660803 | DOI:10.1161/ATVBAHA.124.320969 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 25, 2024 Category: Cardiology Authors: Ashley Soucy Christian Potts Abigail Kaija Anne Harrington Marissa McGilvrey George L Sutphin Ron Korstanje Benjamin Tero Jacob Seeker Ilka Pinz Calvin Vary Larisa Ryzhova Lucy Liaw Source Type: research
SPTLC3 Is Essential for Complex I Activity and Contributes to Ischemic Cardiomyopathy
CONCLUSIONS: Our findings suggest a novel essential role for SPTLC3 in electron transport chain function and a contribution to ischemic injury by regulating complex I activity.PMID:38660786 | DOI:10.1161/CIRCULATIONAHA.123.066879 (Source: Circulation)
Source: Circulation - April 25, 2024 Category: Cardiology Authors: Anna Kovilakath Adolfo G Mauro Yolander Valentine Frank Raucci Maryam Jamil Christiane Carter Jeremy Thompson Qun Chen Beutner Gisela Yang Yue Jeremy Allegood Xiaoxin X Wang Jordan Dail Teja Devarakonda Komuraiah Myakala Jolene J Windle Mark A Subler Davi Source Type: research
Association between Atherosclerosis and High-Risk Colorectal Adenomas based on Cardio-Ankle Vascular Index and Ankle-Brachial Index
CONCLUSIONS: In this study, a significant correlation between positive CAVI and high-risk adenomas was observed. Therefore, CAVI may be a significant predictor for high-risk colorectal adenoma.PMID:38659250 | DOI:10.4166/kjg.2024.003 (Source: Atherosclerosis)
Source: Atherosclerosis - April 25, 2024 Category: Cardiology Authors: Jung Ho Lee Hyunseok Cho Sang Hoon Lee Sung Joon Lee Chang Don Kang Dae Hee Choi Jin Myung Park Seung-Joo Nam Tae Suk Kim Ji Hyun Kim Sung Chul Park Source Type: research
Comparison of Incidence and Prognostic Impact of Ischemic Major Bleeding and Heart Failure Events in Patients With Chronic Coronary Syndrome: Insights From the CORONOR Registry
CONCLUSIONS: Hospitalization for HF has become both the most frequent and one of the most ominous events among patients with chronic coronary syndrome. Although less frequent, major bleeding is strongly associated with worse patient survival. Secondary prevention should not be limited to preventing ischemic events. Minimizing bleeding and preventing HF may be at least as important.PMID:38660793 | DOI:10.1161/CIRCULATIONAHA.123.067938 (Source: Circulation)
Source: Circulation - April 25, 2024 Category: Cardiology Authors: Gilles Lemesle Nicolas Lamblin Guillaume Schurtz Julien Labreuche Alain Duhamel Basile Verdier Philippe Gabriel Steg Christophe Bauters Source Type: research
