Detecting early-warning biomarkers associated with heart-exosome genetic-signature for acute myocardial infarction: A source-tracking study of exosome
J Cell Mol Med. 2024 Apr;28(8):e18334. doi: 10.1111/jcmm.18334.ABSTRACTThe genetic information of plasma total-exosomes originating from tissues have already proven useful to assess the severity of coronary artery diseases (CAD). However, plasma total-exosomes include multiple sub-populations secreted by various tissues. Only analysing the genetic information of plasma total-exosomes is perturbed by exosomes derived from other organs except the heart. We aim to detect early-warning biomarkers associated with heart-exosome genetic-signatures for acute myocardial infarction (AMI) by a source-tracking analysis of plasma exoso...
Source: Molecular Medicine - April 25, 2024 Category: Molecular Biology Authors: Xiaojun Jin Weifeng Xu Qiaoping Wu Chen Huang Yongfei Song Jiangfang Lian Source Type: research
Prevalence of obstructive sleep apnea in patients with chronic obstructive pulmonary disease in Vietnam
CONCLUSIONS: The prevalence of obstructive sleep apnea in patients with chronic obstructive pulmonary disease in Vietnam was 42.1% for an AHI of ≥ 15 events/h.PMID:38662313 | DOI:10.1007/s11325-024-03035-y (Source: Sleep and Breathing)
Source: Sleep and Breathing - April 25, 2024 Category: Sleep Medicine Authors: Bao Khac Le Minh Hoang Source Type: research
Risk Factors and Clinical Characterization of Cardiovascularand Cerebrovascular Events in Elderly Hemodialysis Patients
CONCLUSION: Patients with underlying diseases such as hypertensive or diabetic nephropathy are more likely to experience cardiovascular and cerebrovascular events. Longer dialysis duration, higher systolic and diastolic blood pressures, elevated uric acid, TC, TG, LDL-C, PTH and blood glucose levels, and boosted inflammatory reaction are risk factors for these events among elderly HD patients. The purpose of this study is to provide practical guidelines for clinical treatment. Comprehensive measures such as active intervention of risk factors, rational drug use and regular examination should be taken to improve the overall...
Source: Iranian Journal of Kidney Diseases - April 25, 2024 Category: Urology & Nephrology Authors: Wei Liu Hong Ze Wang Ying Shi Weiqiang Shen Mingyan Dai Source Type: research
The cardiovascular safety of sodium nitroprusside in acute heart failure
Expert Opin Drug Saf. 2024 Apr 25. doi: 10.1080/14740338.2024.2348570. Online ahead of print.NO ABSTRACTPMID:38661629 | DOI:10.1080/14740338.2024.2348570 (Source: Expert Opinion on Drug Safety)
Source: Expert Opinion on Drug Safety - April 25, 2024 Category: Drugs & Pharmacology Authors: Pier Paolo Bocchino Filippo Angelini Guglielmo Gallone Simone Frea Gaetano Maria De Ferrari Source Type: research
SGLT2-independent effects of canagliflozin on NHE3 and mitochondrial complex I activity inhibit proximal tubule fluid transport and albumin uptake
Am J Physiol Renal Physiol. 2024 Apr 25. doi: 10.1152/ajprenal.00005.2024. Online ahead of print.ABSTRACTBeyond glycemic control, SGLT2 inhibitors (SGLT2i) have protective effects on cardiorenal function. Renoprotection has been suggested to involve inhibition of NHE3 leading to reduced ATP-dependent tubular workload and mitochondrial oxygen consumption. NHE3 activity is also important for regulation of endosomal pH, but the effects of SGLT2i on endocytosis are unknown. We used a highly differentiated cell culture model of proximal tubule (PT) cells to determine the direct effects of SGLT2i on Na+-dependent fluid transport...
Source: American Journal of Physiology. Renal Physiology - April 25, 2024 Category: Physiology Authors: Wafaa N Albalawy Elynna B Youm Katherine E Shipman Keelan J Trull Catherine J Baty Kimberly R Long Youssef Rbaibi Xue-Ping Wang Olayemi G Fagunloye Katharine A White Michael J Jurczak Ossama B Kashlan Ora A Weisz Source Type: research
Recurrence of ventricular fibrillation in out-of-hospital cardiac arrest: Clinical evidence and underlying ionic mechanisms
J Physiol. 2024 Apr 25. doi: 10.1113/JP284621. Online ahead of print.ABSTRACTDefibrillation remains the optimal therapy for terminating ventricular fibrillation (VF) in out-of-hospital cardiac arrest (OHCA) patients, with reported shock success rates of ∼90%. A key persistent challenge, however, is the high rate of VF recurrence (∼50-80%) seen during post-shock cardiopulmonary resuscitation (CPR). Studies have shown that the incidence and time spent in recurrent VF are negatively associated with neurologically-intact survival. Recurrent VF also results in the administration of extra shocks at escalating energy levels, ...
Source: The Journal of Physiology - April 25, 2024 Category: Physiology Authors: Sandeep V Pandit Joshua W Lampe Annemarie E Silver Source Type: research
Conceptual Approach to Body Fluids and Edema, Education Determines Clinical Outcomes in Heart Failure
Iran J Kidney Dis. 2024 Mar;18(2):65-67. doi: 10.5254/1aytkx77.ABSTRACTIn this brief communication, we reemphasize the importance of critical thinking in clinical practice using the example of edema. The common practice of thinking and inquiry by practicing clinicians has beneficial implications for healthcare by improving outcomes and patient care while alleviating the burden of misconceptions in practice. We provide an in-depth and interactive investigation of physiological concepts as a foundation for understanding body fluid dynamics. Finally, we offer a new classification of symptoms of heart failure. DOI: 10.52547/ij...
Source: Iranian Journal of Kidney Diseases - April 25, 2024 Category: Urology & Nephrology Authors: Mohammad A Shafiee Amireza Goli Pouyan Shaker Vishal Sharma Yasmin Shahideh Khrystyna Maryniak Behrooz Broumand Source Type: research
Impact of abdominal compression on heart and stomach motion for stereotactic arrhythmia radioablation
CONCLUSIONS: AC was not a consistent motion management method for STAR, nor does not uniformly affect the separation distance between LVCs and the stomach. If AC is employed in future STAR protocols, the motion of the target volume and its relative distance to the stomach should be compared on two 4DCTs: one while the patient is FB and one under AC.PMID:38661250 | DOI:10.1002/acm2.14346 (Source: Journal of Applied Clinical Medical Physics)
Source: Journal of Applied Clinical Medical Physics - April 25, 2024 Category: Physics Authors: Daniel David Cecchi Nicolas Paul Ploquin Salman Faruqi Hali Morrison Source Type: research
Immunoproteasomal Inhibition With ONX-0914 Attenuates Atherosclerosis and Reduces White Adipose Tissue Mass and Metabolic Syndrome in Mice
CONCLUSIONS: We propose that immunoproteasomal inhibition reduces 3 major causes underlying cardiovascular disease, dyslipidemia, metabolic syndrome, and inflammation and is a new target in drug development for atherosclerosis treatment.PMID:38660806 | DOI:10.1161/ATVBAHA.123.319701 (Source: Mol Biol Cell)
Source: Mol Biol Cell - April 25, 2024 Category: Molecular Biology Authors: Frank H Schaftenaar Andrea D van Dam Gerjan de Bruin Marie A C Depuydt Jill de Mol Jacob Amersfoort Hidde Douna Menno Meijer Mara J Kr öner Peter J van Santbrink Mireia N A Bernab é Kleijn Gijs H M van Puijvelde Bogdan I Florea Bram Sl ütter Amanda C F Source Type: research
Detecting early-warning biomarkers associated with heart-exosome genetic-signature for acute myocardial infarction: A source-tracking study of exosome
J Cell Mol Med. 2024 Apr;28(8):e18334. doi: 10.1111/jcmm.18334.ABSTRACTThe genetic information of plasma total-exosomes originating from tissues have already proven useful to assess the severity of coronary artery diseases (CAD). However, plasma total-exosomes include multiple sub-populations secreted by various tissues. Only analysing the genetic information of plasma total-exosomes is perturbed by exosomes derived from other organs except the heart. We aim to detect early-warning biomarkers associated with heart-exosome genetic-signatures for acute myocardial infarction (AMI) by a source-tracking analysis of plasma exoso...
Source: J Cell Mol Med - April 25, 2024 Category: Molecular Biology Authors: Xiaojun Jin Weifeng Xu Qiaoping Wu Chen Huang Yongfei Song Jiangfang Lian Source Type: research
Pulmonary-vein-to-pulmonary-artery ratio can be utilized to evaluate myxomatous mitral valve disease progression in dogs
Am J Vet Res. 2024 Apr 29:1-8. doi: 10.2460/ajvr.24.01.0004. Online ahead of print.ABSTRACTOBJECTIVE: To evaluate the diagnostic value of pulmonary-vein-to-pulmonary-artery ratio (PV:PA) in dogs with myxomatous mitral valve degeneration (MMVD), classified according to the American College of Veterinary Internal Medicine (ACVIM) consensus guidelines.ANIMALS: 80 client-owned dogs with either MMVD (n = 65) or no cardiovascular disease (control group; n = 15) between August 5, 2020, and July 19, 2023.METHODS: This is a retrospective study. Dogs with MMVD were classified according to ACVIM consensus guidelines. Echocardiograms,...
Source: American Journal of Veterinary Research - April 25, 2024 Category: Veterinary Research Authors: Min-Suk Kim Jiyoung Kim Min Woong Seo Chul Park Source Type: research
The latest emerging drugs for the treatment of diabetic cardiomyopathy
Expert Opin Pharmacother. 2024 Apr 25. doi: 10.1080/14656566.2024.2347468. Online ahead of print.ABSTRACTINTRODUCTION: Diabetic cardiomyopathy (DCM) is a serious complication of diabetes mellitus involving multiple pathophysiologic mechanisms. In addition to hypoglycemic agents commonly used in diabetes, metabolism-related drugs, natural plant extracts, melatonin, exosomes, and rennin-angiotensin-aldosterone system are cardioprotective in DCM. However, there is a lack of systematic summarization of drugs for DCM.AREAS COVERED: In this review, the authors systematically summarize the most recent drugs used for the treatment...
Source: Expert Opinion on Pharmacotherapy - April 25, 2024 Category: Drugs & Pharmacology Authors: Minghao Li Lin Liu Chunyu Zhang Li Deng Yi Zhong Bin Liao Xiuying Li Ying Wan Jian Feng Source Type: research
SGLT2-independent effects of canagliflozin on NHE3 and mitochondrial complex I activity inhibit proximal tubule fluid transport and albumin uptake
Am J Physiol Renal Physiol. 2024 Apr 25. doi: 10.1152/ajprenal.00005.2024. Online ahead of print.ABSTRACTBeyond glycemic control, SGLT2 inhibitors (SGLT2i) have protective effects on cardiorenal function. Renoprotection has been suggested to involve inhibition of NHE3 leading to reduced ATP-dependent tubular workload and mitochondrial oxygen consumption. NHE3 activity is also important for regulation of endosomal pH, but the effects of SGLT2i on endocytosis are unknown. We used a highly differentiated cell culture model of proximal tubule (PT) cells to determine the direct effects of SGLT2i on Na+-dependent fluid transport...
Source: Am J Physiol Renal P... - April 25, 2024 Category: Urology & Nephrology Authors: Wafaa N Albalawy Elynna B Youm Katherine E Shipman Keelan J Trull Catherine J Baty Kimberly R Long Youssef Rbaibi Xue-Ping Wang Olayemi G Fagunloye Katharine A White Michael J Jurczak Ossama B Kashlan Ora A Weisz Source Type: research
Parents' Trigger Tool for Children with Medical Complexity - PAT-CMC: Development of a recognition tool for clinical deterioration at home
CONCLUSION: Priority indicators of clinical deterioration of CMC were identified and integrated into a validated trigger tool designed for parents or other lay caregivers at home, to recognize signs of acute severe illness and initiate healthcare interventions.IMPACT: The PAT-CMC was developed to guide families in recognizing signs of deterioration in CMC and has potential for initiating an early escalation of care. This tool may also be useful to support education provided by healthcare providers to families before hospital discharge.PATIENT OR PUBLIC CONTRIBUTION: Parents of CMC were directly involved in the selection of...
Source: Adv Data - April 25, 2024 Category: Epidemiology Authors: Catia Genna Kiara Ros Thekkan Caterina Geremia Michela Di Furia Corrado Cecchetti Emilia Rufini Michele Salata Daniela Perrotta Immacolata Dall'Oglio Emanuela Tiozzo Massimiliano Raponi Orsola Gawronski Source Type: research
A Bibliometric Analysis of Study of Associations of Certain Genotypes with the Cardiovascular Form of Diabetic Neuropathy
Biomed Res Int. 2024 Apr 15;2024:6761451. doi: 10.1155/2024/6761451. eCollection 2024.ABSTRACTThis bibliometric analysis explores the landscape of research on the associations between specific genotypes and the cardiovascular form of diabetic neuropathy. Diabetes mellitus (DM) is a major contributor to premature mortality, primarily due to increased susceptibility to cardiovascular diseases. The global prevalence of DM is rising, with projections indicating further increases. Diabetic neuropathy, a complication of DM, includes the cardiovascular subtype, posing challenges in diagnosis and management. Understanding the gene...
Source: Biomed Res - April 25, 2024 Category: Research Authors: Nazira B Bekenova Tamara A Vochshenkova Nurgul Ablakimova Aliya Zhylkybekova Nadiar M Mussin Rustam K Albayev Asset A Kaliyev Amin Tamadon Source Type: research
