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Equine gamma herpesvirus presence and viral load are not associated with equine glandular gastric disease
Am J Vet Res. 2024 Mar 18:1-9. doi: 10.2460/ajvr.23.12.0282. Online ahead of print.ABSTRACTOBJECTIVE: To investigate the role of equine herpesvirus-2 (EHV-2) and equine herpesvirus-5 (EHV-5) in equine glandular gastric disease (EGGD) by visualizing and quantifying these gamma herpesviruses in EGGD-affected and normal glandular gastric mucosa of horses. A secondary objective was to describe the histopathological abnormalities in the equine gastric glandular mucosa in horses with EGGD.ANIMALS: 29 horses (n = 21 postmortem and 8 gastroscopy) categorized as normal (11), EGGD (12), or both EGGD and equine squamous gastric disea...
Source: American Journal of Veterinary Research - March 14, 2024 Category: Veterinary Research Authors: Rachelle N Thompson Erin Pearson Sean P McDonough Helenrose Iannitti Gerlinde R Van de Walle Heidi Banse Gillian A Perkins Joy E Tomlinson Source Type: research
Hemadsorption extracorporeal therapy removes cytokines ex vivo in horses
Am J Vet Res. 2024 Mar 18:1-8. doi: 10.2460/ajvr.24.01.0022. Online ahead of print.ABSTRACTOBJECTIVE: Plasma cytokine adsorption has shown benefit as an adjunctive therapy in human sepsis but has yet to be investigated in horses. We hypothesized that ex vivo filtration of equine plasma with a novel cytokine adsorption device would significantly reduce concentrations of lipopolysaccharide-stimulated cytokines. We also hypothesized that the device would adsorb medications commonly used to treat sepsis.ANIMALS: 8 horses owned by North Carolina State University.METHODS: Four liters of heparinized whole blood was collected from...
Source: American Journal of Veterinary Research - March 14, 2024 Category: Veterinary Research Authors: Kallie J Hobbs Jennifer L Davis Bethanie L Cooper Yu Ueda Megan J Burke M Katie Sheats Source Type: research
Equine gamma herpesvirus presence and viral load are not associated with equine glandular gastric disease
Am J Vet Res. 2024 Mar 18:1-9. doi: 10.2460/ajvr.23.12.0282. Online ahead of print.ABSTRACTOBJECTIVE: To investigate the role of equine herpesvirus-2 (EHV-2) and equine herpesvirus-5 (EHV-5) in equine glandular gastric disease (EGGD) by visualizing and quantifying these gamma herpesviruses in EGGD-affected and normal glandular gastric mucosa of horses. A secondary objective was to describe the histopathological abnormalities in the equine gastric glandular mucosa in horses with EGGD.ANIMALS: 29 horses (n = 21 postmortem and 8 gastroscopy) categorized as normal (11), EGGD (12), or both EGGD and equine squamous gastric disea...
Source: American Journal of Veterinary Research - March 14, 2024 Category: Veterinary Research Authors: Rachelle N Thompson Erin Pearson Sean P McDonough Helenrose Iannitti Gerlinde R Van de Walle Heidi Banse Gillian A Perkins Joy E Tomlinson Source Type: research
Hemadsorption extracorporeal therapy removes cytokines ex vivo in horses
Am J Vet Res. 2024 Mar 18:1-8. doi: 10.2460/ajvr.24.01.0022. Online ahead of print.ABSTRACTOBJECTIVE: Plasma cytokine adsorption has shown benefit as an adjunctive therapy in human sepsis but has yet to be investigated in horses. We hypothesized that ex vivo filtration of equine plasma with a novel cytokine adsorption device would significantly reduce concentrations of lipopolysaccharide-stimulated cytokines. We also hypothesized that the device would adsorb medications commonly used to treat sepsis.ANIMALS: 8 horses owned by North Carolina State University.METHODS: Four liters of heparinized whole blood was collected from...
Source: American Journal of Veterinary Research - March 14, 2024 Category: Veterinary Research Authors: Kallie J Hobbs Jennifer L Davis Bethanie L Cooper Yu Ueda Megan J Burke M Katie Sheats Source Type: research
Equine gamma herpesvirus presence and viral load are not associated with equine glandular gastric disease
Am J Vet Res. 2024 Mar 18:1-9. doi: 10.2460/ajvr.23.12.0282. Online ahead of print.ABSTRACTOBJECTIVE: To investigate the role of equine herpesvirus-2 (EHV-2) and equine herpesvirus-5 (EHV-5) in equine glandular gastric disease (EGGD) by visualizing and quantifying these gamma herpesviruses in EGGD-affected and normal glandular gastric mucosa of horses. A secondary objective was to describe the histopathological abnormalities in the equine gastric glandular mucosa in horses with EGGD.ANIMALS: 29 horses (n = 21 postmortem and 8 gastroscopy) categorized as normal (11), EGGD (12), or both EGGD and equine squamous gastric disea...
Source: American Journal of Veterinary Research - March 14, 2024 Category: Veterinary Research Authors: Rachelle N Thompson Erin Pearson Sean P McDonough Helenrose Iannitti Gerlinde R Van de Walle Heidi Banse Gillian A Perkins Joy E Tomlinson Source Type: research
Hemadsorption extracorporeal therapy removes cytokines ex vivo in horses
Am J Vet Res. 2024 Mar 18:1-8. doi: 10.2460/ajvr.24.01.0022. Online ahead of print.ABSTRACTOBJECTIVE: Plasma cytokine adsorption has shown benefit as an adjunctive therapy in human sepsis but has yet to be investigated in horses. We hypothesized that ex vivo filtration of equine plasma with a novel cytokine adsorption device would significantly reduce concentrations of lipopolysaccharide-stimulated cytokines. We also hypothesized that the device would adsorb medications commonly used to treat sepsis.ANIMALS: 8 horses owned by North Carolina State University.METHODS: Four liters of heparinized whole blood was collected from...
Source: American Journal of Veterinary Research - March 14, 2024 Category: Veterinary Research Authors: Kallie J Hobbs Jennifer L Davis Bethanie L Cooper Yu Ueda Megan J Burke M Katie Sheats Source Type: research
Clippers are superior to scissors in the collection of hair for chemical analysis in companion dogs: a Dog Aging Project preliminary study
Am J Vet Res. 2024 Mar 18:1-7. doi: 10.2460/ajvr.23.12.0293. Online ahead of print.ABSTRACTOBJECTIVE: To identify the safest, most efficient method for hair sample collection from companion dogs among clippers, scissors, and razors and to validate obtained samples with cortisol concentration analysis.ANIMALS: 25 healthy, privately owned dogs.METHODS: 2 hair samples were collected from each dog's ischiatic region with different implements (scissors, razors, or clippers). The collecting clinician completed a Hair Collection Questionnaire (HCQ) for each sample that compared subjective sample quality, time of collection, restr...
Source: American Journal of Veterinary Research - March 13, 2024 Category: Veterinary Research Authors: Bobbie Ditzler Jeremy B Evans Kate Illing Matt Kaeberlein Daniel E L Promislow Eleanor Brindle Jessica M Hoffman Kate E Creevy Source Type: research
A newly developed recovery-enhancing device improves recovery scores during emergence from general anesthesia in horses: a randomized trial
Am J Vet Res. 2024 Mar 18:1-6. doi: 10.2460/ajvr.24.02.0024. Online ahead of print.ABSTRACTOBJECTIVE: To compare the quality of recovery in horses emerging from general anesthesia with or without the assistance of a novel device (recovery-enhancing device [RED]) designed to minimize high-energy falls.ANIMALS: 20 mixed-breed horses, between July 1, 2023, and January 24, 2024.METHODS: A computer-controlled belay system designed to slow the acceleration of a horse during a fall was evaluated in this study. Horses were randomly assigned to 1 of 2 treatment groups: RED (belay, assisted) or FREE (unassisted). An inertia-measurin...
Source: American Journal of Veterinary Research - March 13, 2024 Category: Veterinary Research Authors: Luis Campoy Manuel Martin-Flores Joaquin Araos Stephen A Parry Robin D Gleed Source Type: research
Clippers are superior to scissors in the collection of hair for chemical analysis in companion dogs: a Dog Aging Project preliminary study
Am J Vet Res. 2024 Mar 18:1-7. doi: 10.2460/ajvr.23.12.0293. Online ahead of print.ABSTRACTOBJECTIVE: To identify the safest, most efficient method for hair sample collection from companion dogs among clippers, scissors, and razors and to validate obtained samples with cortisol concentration analysis.ANIMALS: 25 healthy, privately owned dogs.METHODS: 2 hair samples were collected from each dog's ischiatic region with different implements (scissors, razors, or clippers). The collecting clinician completed a Hair Collection Questionnaire (HCQ) for each sample that compared subjective sample quality, time of collection, restr...
Source: American Journal of Veterinary Research - March 13, 2024 Category: Veterinary Research Authors: Bobbie Ditzler Jeremy B Evans Kate Illing Matt Kaeberlein Daniel E L Promislow Eleanor Brindle Jessica M Hoffman Kate E Creevy Source Type: research
A newly developed recovery-enhancing device improves recovery scores during emergence from general anesthesia in horses: a randomized trial
Am J Vet Res. 2024 Mar 18:1-6. doi: 10.2460/ajvr.24.02.0024. Online ahead of print.ABSTRACTOBJECTIVE: To compare the quality of recovery in horses emerging from general anesthesia with or without the assistance of a novel device (recovery-enhancing device [RED]) designed to minimize high-energy falls.ANIMALS: 20 mixed-breed horses, between July 1, 2023, and January 24, 2024.METHODS: A computer-controlled belay system designed to slow the acceleration of a horse during a fall was evaluated in this study. Horses were randomly assigned to 1 of 2 treatment groups: RED (belay, assisted) or FREE (unassisted). An inertia-measurin...
Source: American Journal of Veterinary Research - March 13, 2024 Category: Veterinary Research Authors: Luis Campoy Manuel Martin-Flores Joaquin Araos Stephen A Parry Robin D Gleed Source Type: research
Vertebral heart size and vertebral left atrial size reference ranges in healthy Miniature Schnauzers
Am J Vet Res. 2024 Mar 15:1-5. doi: 10.2460/ajvr.24.01.0010. Online ahead of print.ABSTRACTOBJECTIVE: The inclusion of vertebral heart score (VHS) and, more recently, the inclusion of the vertebral left atrial size (VLAS) in radiographic evaluation have become important screening tools for identifying dogs with occult cardiac disease. Several recent papers have shown there are interbreed variations in the VHS reference range. Our hypothesis is that the Miniature Schnauzer would also have a higher reference range for its VHS.ANIMALS: The electronic medical records of IDEXX Telemedicine Consultants were searched for Miniatur...
Source: American Journal of Veterinary Research - March 11, 2024 Category: Veterinary Research Authors: Lisa Murphy Nicole Piscitelli Jessica Solomon Donald Szlosek Reid K Nakamura Source Type: research
A complex cyclical One Health pathway drives the emergence and dissemination of antimicrobial resistance
Am J Vet Res. 2024 Mar 9:1-9. doi: 10.2460/ajvr.24.01.0014. Online ahead of print.ABSTRACTSince their commercialization, scientists have known that antimicrobial use kills or inhibits susceptible bacteria while allowing resistant bacteria to survive and expand. Today there is widespread antimicrobial resistance (AMR), even to antimicrobials of last resort such as the carbapenems, which are reserved for use in life-threatening infections. It is often convenient to assign responsibility for this global health crisis to the users and prescribers of antimicrobials. However, we know that animals never treated with antimicrobial...
Source: American Journal of Veterinary Research - March 11, 2024 Category: Veterinary Research Authors: Elizabeth M Parker Gregory A Ballash Dixie F Mollenkopf Thomas E Wittum Source Type: research
Vertebral heart size and vertebral left atrial size reference ranges in healthy Miniature Schnauzers
Am J Vet Res. 2024 Mar 15:1-5. doi: 10.2460/ajvr.24.01.0010. Online ahead of print.ABSTRACTOBJECTIVE: The inclusion of vertebral heart score (VHS) and, more recently, the inclusion of the vertebral left atrial size (VLAS) in radiographic evaluation have become important screening tools for identifying dogs with occult cardiac disease. Several recent papers have shown there are interbreed variations in the VHS reference range. Our hypothesis is that the Miniature Schnauzer would also have a higher reference range for its VHS.ANIMALS: The electronic medical records of IDEXX Telemedicine Consultants were searched for Miniatur...
Source: American Journal of Veterinary Research - March 11, 2024 Category: Veterinary Research Authors: Lisa Murphy Nicole Piscitelli Jessica Solomon Donald Szlosek Reid K Nakamura Source Type: research
A complex cyclical One Health pathway drives the emergence and dissemination of antimicrobial resistance
Am J Vet Res. 2024 Mar 9:1-9. doi: 10.2460/ajvr.24.01.0014. Online ahead of print.ABSTRACTSince their commercialization, scientists have known that antimicrobial use kills or inhibits susceptible bacteria while allowing resistant bacteria to survive and expand. Today there is widespread antimicrobial resistance (AMR), even to antimicrobials of last resort such as the carbapenems, which are reserved for use in life-threatening infections. It is often convenient to assign responsibility for this global health crisis to the users and prescribers of antimicrobials. However, we know that animals never treated with antimicrobial...
Source: American Journal of Veterinary Research - March 11, 2024 Category: Veterinary Research Authors: Elizabeth M Parker Gregory A Ballash Dixie F Mollenkopf Thomas E Wittum Source Type: research
Injection rate, scanning position, and values of parameters on pulmonary computed tomography perfusion in normal Beagles
This study evaluated the effects of scanning position and contrast medium injection rate on pulmonary CT perfusion (CTP) images in healthy dogs.ANIMALS: 7 healthy Beagles.METHODS: Experiments involved 4 conditions: dorsal and sternal recumbency at 2.5 mL/s (first) and sternal recumbency with additional rates of 1.5 and 3.5 mL/s (second). Various parameters, including the initial time of venous enhancement (Tv), peak time of arterial enhancement (PTa), and peak enhancement values of the artery, were measured. The PTa to Tv interval was calculated. Perfusion mapping parameters (pulmonary blood flow, pulmonary blood volume, m...
Source: American Journal of Veterinary Research - March 8, 2024 Category: Veterinary Research Authors: Hyunju Hwang Changhyeon Cho Myounghun Kim Wonbeom Jung Hackjoon Shim Jaehwan Kim Kidong Eom Source Type: research