Biochemical, functional, and histopathologic characterization of lomustine-induced liver injury in dogs.
CONCLUSIONS AND CLINICAL RELEVANCE: In dogs, liver enzyme activities, particularly ALT and ALP activities, should be closely monitored during lomustine treatment and acute increases in those activities may warrant discontinuation of lomustine to mitigate liver injury. Nonspecific ultrasonographic findings and abnormal increases in liver function tests were not detected until the onset of clinical liver failure. Glutathione depletion may have a role in lomustine-induced hepatopathy and warrants further investigation. PMID: 32969725 [PubMed - in process] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - September 26, 2020 Category: Veterinary Research Authors: Dedeaux AM, Flesner BK, Reinhart JM, Langohr IM, Husnik R, Geraci SN, Taboada J, Rademacher N, Thombs LA, Bryan JN, Trepanier LA, Boudreaux BB Tags: Am J Vet Res Source Type: research

In vitro holding security of four friction knots of monofilament or multifilament suture used as a first throw for vascular ligation.
CONCLUSIONS AND CLINICAL RELEVANCE: Most differences in knot security, although statistically significant, may not have been clinically relevant. However, results of these in vitro tests suggested the surgeon's throw should be avoided as a first throw for pedicle ligation and that poliglecaprone-25 may be more prone to friction knot slippage than the other suture materials evaluated. PMID: 32969726 [PubMed - in process] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - September 26, 2020 Category: Veterinary Research Authors: Tremolada G, Hazenfield KM, Smeak DD Tags: Am J Vet Res Source Type: research

Erratum: Ultrasonographic and hormonal characterization of reproductive health and disease in wild, semiwild, and aquarium-housed southern stingrays (Hypanus americanus).
Authors: PMID: 32969727 [PubMed] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - September 26, 2020 Category: Veterinary Research Tags: Am J Vet Res Source Type: research

Reliability of kinetic measurements of healthy dogs examined while walking on a treadmill.
CONCLUSIONS AND CLINICAL RELEVANCE: The %SPD of healthy dogs walking on a treadmill was the most sensitive and diagnostically reliable of the measured kinetic parameters, in contrast to VI and RSL. Findings suggested that actual changes can be distinguished from random physiologic fluctuations during gait analysis of dogs. PMID: 32969728 [PubMed - in process] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - September 26, 2020 Category: Veterinary Research Authors: Pietsch S, Steigmeier-Raith S, Reese S, Meyer-Lindenberg A Tags: Am J Vet Res Source Type: research

Transference of reference intervals for variables of instrumented gait analysis in walking dogs.
CONCLUSIONS AND CLINICAL RELEVANCE: Use of the small data approach method of the CLSI to validate transference of RIs for IGA kinetic variables in walking dogs was simple and efficient to perform and may help facilitate clinical and research collaborations on gait analysis. PMID: 32969729 [PubMed - in process] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - September 26, 2020 Category: Veterinary Research Authors: Olsen AM, Lambrechts NE, Weng HY, Kazmierczak KA, Duerr FM, Breur GJ Tags: Am J Vet Res Source Type: research

Comparison of intestinal leak pressure between cadaveric canine and commercial synthetic intestinal tissue that did and did not undergo enterotomy.
CONCLUSIONS AND CLINICAL RELEVANCE: Leak testing should not be used to assess the accuracy or security of enterotomy suture lines in synthetic intestinal tissue. Synthetic intestinal tissue is best used for students to gain confidence and proficiency in performing enterotomies before performing the procedure on live animals. PMID: 32969730 [PubMed - in process] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - September 26, 2020 Category: Veterinary Research Authors: Regier PJ, Fealey MJ, Kim SE, Case JB, Garcia-Pereira F Tags: Am J Vet Res Source Type: research

Single-dose pharmacokinetics of orally administered metronidazole and intravenously administered imipenem in healthy horses and computer-based simulation of pleural fluid concentrations with multiple dosing.
CONCLUSIONS AND CLINICAL RELEVANCE: Results suggested that administration of metronidazole (15 mg/kg, PO, q 8 h) or imipenem (10 mg/kg, IV, q 8 h) resulted in their accumulation in the pleural fluid in healthy horses and concentrations were likely to be effective for the treatment of pneumonia and pleuropneumonia caused by Bacteroides spp. PMID: 32969731 [PubMed - in process] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - September 26, 2020 Category: Veterinary Research Authors: Kuroda T, Nagata SI, Tamura N, Kinoshita Y, Niwa H, Mita H, Minami T, Fukuda K, Hobo S, Kuwano A Tags: Am J Vet Res Source Type: research

Evaluation of the changes in hepatic apparent diffusion coefficient and hepatic fat fraction in healthy cats during body weight gain.
CONCLUSIONS AND CLINICAL RELEVANCE: Similar to findings in people, cats had decreasing hepatic ADC as HFF increased. Protons associated with fat tissue in the liver may reduce diffusivity, resulting in a lower ADC than in liver with lower HFF. Longer studies and evaluation of cats with different nutritional states are necessary to further investigate these findings. PMID: 32969732 [PubMed - in process] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - September 26, 2020 Category: Veterinary Research Authors: Steger GL, Salesov E, Richter H, Reusch CE, Kircher PR, Del Chicca F Tags: Am J Vet Res Source Type: research

Evaluation of the thermal antinociceptive effects of hydromorphone hydrochloride after intramuscular administration to orange-winged Amazon parrots (Amazona amazonica).
CONCLUSIONS AND CLINICAL RELEVANCE: Although the 1- and 2-mg/kg hydromorphone doses appeared to have antinociceptive effects, they also caused agitation, signs of nausea, and ataxia. Further research is necessary to evaluate administration of lower doses of hydromorphone and other types of stimulation to better elucidate the analgesic and adverse effects of the drug in psittacine species. PMID: 32969733 [PubMed - in process] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - September 26, 2020 Category: Veterinary Research Authors: Sanchez-Migallon Guzman D, Douglas JM, Beaufrère H, Paul-Murphy JR Tags: Am J Vet Res Source Type: research

JAVMA News Digest.
Authors: PMID: 32969734 [PubMed - in process] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - September 26, 2020 Category: Veterinary Research Tags: Am J Vet Res Source Type: research

Assessment of skin staples for augmentation of core tenorrhaphy in an ex vivo model of canine superficial digital flexor tendon laceration.
CONCLUSIONS AND CLINICAL RELEVANCE: Results indicated epitendinous placement of skin staples around a core SDFT tenorrhaphy site improved the biomechanical strength and resistance to gap formation for the repair but was inferior to epitendinous placement of SXS sutures. Further research is necessary before skin staples are used for tenorrhaphy augmentation in clinical patients. PMID: 32700993 [PubMed - in process] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - July 25, 2020 Category: Veterinary Research Authors: Chang YJ, Duffy DJ, Gaffney L, Fisher MB, Moore GE Tags: Am J Vet Res Source Type: research

Pharmacokinetics of amantadine after oral administration of single and multiple doses to orange-winged Amazon parrots (Amazona amazonica).
CONCLUSIONS AND CLINICAL RELEVANCE: Once-daily oral administration of amantadine at 5 mg/kg to orange-winged Amazon parrots maintained plasma concentrations above those considered to be therapeutic in dogs. Further studies evaluating safety and efficacy of amantadine in orange-winged Amazon parrots are warranted. PMID: 32700994 [PubMed - in process] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - July 25, 2020 Category: Veterinary Research Authors: Berg KJ, Sanchez-Migallon Guzman D, Knych HK, Drazenovich TL, Paul-Murphy JR Tags: Am J Vet Res Source Type: research

Efficacy of sodium iodide for prevention of respiratory disease in preweaned dairy calves.
CONCLUSIONS AND CLINICAL RELEVANCE: Results suggested that, although oral administration of NaI (20 mg/kg) to preweaned dairy calves achieved iodine concentrations presumed to be effective in both serum and nasal fluid, it was not effective for prevention of BRD in preweaned calves at a commercial calf-raising facility. PMID: 32700995 [PubMed - in process] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - July 25, 2020 Category: Veterinary Research Authors: Gamsjäger L, Vander Ley BL, Knych HK, McArthur GR, Heller MC Tags: Am J Vet Res Source Type: research

Investigation for correction formulas on the basis of packed cell volume for blood glucose concentration measurements obtained with portable glucometers when used in rabbits.
CONCLUSIONS AND CLINICAL RELEVANCE: Findings indicated that, in rabbits, HPBG measurements had improved accuracy with the use of the correction formula HPBG measurement of BG concentration + ([0.75 × PCV] - 15); however, the correction formulas did not improve the accuracy of VPBG measurements, and we believe that neither the cVPBG nor fVPBG should be used in rabbits. PMID: 32700996 [PubMed - in process] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - July 25, 2020 Category: Veterinary Research Authors: Cutler DC, Koenig A, Di Girolamo N, Mayer J Tags: Am J Vet Res Source Type: research

JAVMA News Digest.
Authors: PMID: 32700997 [PubMed - in process] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - July 25, 2020 Category: Veterinary Research Tags: Am J Vet Res Source Type: research

Ex vivo modeling of the airflow dynamics and two-and three-dimensional biomechanical effects of suture placements for prosthetic laryngoplasty in horses.
CONCLUSIONS AND CLINICAL RELEVANCE: Ex vivo modeling results suggested little benefit to LAC abduction forces> 50%, which allowed airflow similar to that reported elsewhere for galloping horses. PMID: 32700998 [PubMed - in process] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - July 25, 2020 Category: Veterinary Research Authors: Lynch NP, Jones SA, Bazley-White LG, Wilson ZF, Raffetto J, Pfau T, Cheetham J, Perkins JD Tags: Am J Vet Res Source Type: research

Pharmacokinetics and pharmacodynamics of a novel analgesic with a deterrent to human opioid abuse (methadone-fluconazole-naltrexone) after oral administration in dogs.
CONCLUSIONS AND CLINICAL RELEVANCE: Opioid effects were detected after oral administration of methadone-fluconazole or methadone-fluconazole-naltrexone. Further studies assessing additional opioid effects, including antinociception, are needed. PMID: 32700999 [PubMed - in process] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - July 25, 2020 Category: Veterinary Research Authors: KuKanich B, KuKanich K, Rankin DC, Locuson CW, Joo H Tags: Am J Vet Res Source Type: research

Clinical evaluation of arterial blood pressure in anesthetized dogs by use of a veterinary-specific multiparameter monitor.
CONCLUSIONS AND CLINICAL RELEVANCE: NIBP measurements with the studied veterinary-specific multiparameter monitor generally agreed with IBP measurements during hypotensive and normotensive periods for anesthetized healthy female dogs undergoing routine ovariohysterectomy. However, inaccuracies, frequently underestimations, were observed during periods of hypertension, and therefore, NIBP measurements should be interpreted cautiously. PMID: 32701000 [PubMed - in process] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - July 25, 2020 Category: Veterinary Research Authors: Jacobs-Fohrman ZR, Barnes TS, McEwen MM, Goodwin WA Tags: Am J Vet Res Source Type: research

Comparison of the effects on lameness of orally administered acetaminophen-codeine and carprofen in dogs with experimentally induced synovitis.
CONCLUSIONS AND CLINICAL RELEVANCE: Carprofen as administered was more effective than AC at attenuating SU-induced lameness in dogs. PMID: 32701001 [PubMed - in process] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - July 25, 2020 Category: Veterinary Research Authors: Budsberg SC, Kleine SA, Norton MM, Sandberg GS, Papich MG Tags: Am J Vet Res Source Type: research

Comparison of analgesic and tissue effects of subcutaneous perineural injection of liposomal bupivacaine and bupivacaine hydrochloride in horses with forelimb lameness induced via circumferential clamp.
CONCLUSIONS AND CLINICAL RELEVANCE: SC perineural injection of 10 mg of liposomal bupivacaine/site ameliorated experimentally induced forelimb lameness in some horses. At milligram-equivalent doses, liposomal bupivacaine had a similar duration of analgesia to that of bupivacaine HCl. Further investigation is required before recommending clinical use of liposomal bupivacaine for nerve blocks in horses. PMID: 32584174 [PubMed - in process] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - June 27, 2020 Category: Veterinary Research Authors: Le KM, Caston SS, Hossetter JM, Hay Kraus BL Tags: Am J Vet Res Source Type: research

Book Reviews.
Authors: PMID: 32584175 [PubMed - in process] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - June 27, 2020 Category: Veterinary Research Tags: Am J Vet Res Source Type: research

Biomechanical evaluation of an absorbable fixation strap for use in total laparoscopic gastropexy in dogs.
CONCLUSIONS AND CLINICAL RELEVANCE: Results of the present study supported the potential use of AFSs in gastropexy in dogs; however, prospective clinical research with adequate long-term follow-up is warranted before recommendations can be made. PMID: 32584176 [PubMed - in process] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - June 27, 2020 Category: Veterinary Research Authors: Fracassi L, Crovace AM, Staffieri F, Lacitignola L Tags: Am J Vet Res Source Type: research

Activities of matrix metalloproteinase-2, matrix metalloproteinase-9, and serine proteases in samples of the colorectal mucosa of Miniature Dachshunds with inflammatory colorectal polyps.
CONCLUSIONS AND CLINICAL RELEVANCE: Study results suggested that gelatinase and serine protease activities are upregulated in the colorectal mucosa of MDs with ICRPs, possibly contributing to the pathogenesis of this disease through the functions of these enzymes in degradation of extracellular matrix and promotion of inflammatory cell migration and inflammatory responses. PMID: 32584177 [PubMed - in process] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - June 27, 2020 Category: Veterinary Research Authors: Nagata N, Ohta H, Yamada A, Teoh YB, Ichii O, Morishita K, Sasaki N, Takiguchi M Tags: Am J Vet Res Source Type: research

Pathogenesis, detection, and control of scrapie in sheep.
Abstract In sheep, scrapie is a fatal neurologic disease that is caused by a misfolded protein called a prion (designated PrPSc). The normal cellular prion protein (PrPC) is encoded by an endogenous gene, PRNP, that is present in high concentrations within the CNS. Although a broad range of functions has been described for PrPC, its entire range of functions has yet to be fully elucidated. Accumulation of PrPSc results in neurodegeneration. The PRNP gene has several naturally occurring polymorphisms, and there is a strong correlation between scrapie susceptibility and PRNP genotype. The cornerstone of scrapie erad...
Source: American Journal of Veterinary Research - June 27, 2020 Category: Veterinary Research Authors: Cassmann ED, Greenlee JJ Tags: Am J Vet Res Source Type: research

JAVMA News Digest.
Authors: PMID: 32584179 [PubMed - in process] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - June 27, 2020 Category: Veterinary Research Tags: Am J Vet Res Source Type: research

Evaluation of the thermal antinociceptive effects of subcutaneous administration of butorphanol tartrate or butorphanol tartrate in a sustained-release poloxamer 407 gel formulation to orange-winged Amazon parrots (Amazona amazonica).
CONCLUSIONS AND CLINICAL RELEVANCE: Results suggested a small but significant thermal antinociceptive effect of butorphanol tartrate lasting between 30 minutes and 1.5 hours in orange-winged Amazon parrots. No antinociceptive effect of butorphanol tartrate was demonstrated when delivered in P407. Further research is needed to evaluate the potential analgesic effects of But-P407. PMID: 32584180 [PubMed - in process] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - June 27, 2020 Category: Veterinary Research Authors: Laniesse D, Sanchez-Migallon Guzman D, Smith DA, Douglas JM, Mosley C, Beaufrère H, Paul-Murphy J Tags: Am J Vet Res Source Type: research

Assessment of luteinizing hormone receptor expression in structural support tissues of canine hip and femorotibial joints.
CONCLUSIONS AND CLINICAL RELEVANCE: Results indicated that LHRs are expressed in structural support tissues of canine hip and femorotibial joints. Further research is required to determine the LHRs' function, mechanism of action, and potential contribution to the pathogenesis of hip dysplasia or CCL rupture in dogs. PMID: 32584181 [PubMed - in process] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - June 27, 2020 Category: Veterinary Research Authors: Kiefel CA, Kutzler MA Tags: Am J Vet Res Source Type: research

Erratum: Effects of intra-articular administration of lidocaine, mepivacaine, and the preservative methyl parahydroxybenzoate on synovial fluid biomarkers of horses.
Authors: PMID: 32584182 [PubMed - in process] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - June 27, 2020 Category: Veterinary Research Tags: Am J Vet Res Source Type: research

Letters to the Editor.
Authors: PMID: 32584183 [PubMed - in process] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - June 27, 2020 Category: Veterinary Research Tags: Am J Vet Res Source Type: research

Comparison of torsional properties between a Fixateur Externe du Service de Sant é des Armées and an acrylic tie-in external skeletal fixator in a red-tailed hawk (Buteo jamaicensis) synthetic tibiotarsal bone model.
CONCLUSIONS AND CLINICAL RELEVANCE: Although acrylic bar ESFs have been successfully used in avian patients, the FESSA constructs in this study were mechanically superior to acrylic bar constructs, with greatest benefit resulting from use with the larger TP configuration. PMID: 32584184 [PubMed - in process] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - June 27, 2020 Category: Veterinary Research Authors: Hersh-Boyle RA, Kapatkin AS, Garcia TC, Robinson DA, Sanchez-Migallon Guzman D, Kerrigan SM, Chou PY, Stover SM Tags: Am J Vet Res Source Type: research

Comparison of analgesic efficacy and fetal effects between transdermal administration of fentanyl and intramuscular administration of buprenorphine in pregnant sheep.
CONCLUSIONS AND CLINICAL RELEVANCE: Results indicated that both protocols provided acceptable analgesia. However, the fentanyl protocol was superior in regard to the extent of analgesia induced, inhalant-sparing effects, and anesthesia recovery time. PMID: 32584185 [PubMed - in process] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - June 27, 2020 Category: Veterinary Research Authors: Padgett AL, Lepiz ML, Mackay EE, Driskill AJ, Ivanov IV, Fajt VR, Konarik MM, Mays TP, Washburn SE Tags: Am J Vet Res Source Type: research

Establishment of a method for evaluation of the efficacy of a classical swine fever virus subunit vaccine in rabbits.
CONCLUSIONS AND CLINICAL RELEVANCE: A method was established in rabbits for evaluation of the efficacy of a CSFV subunit vaccine that could help in the optimization of later large-scale vaccine production and quality control processes as well as in the clinical application of the vaccine. PMID: 32436789 [PubMed - in process] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - May 23, 2020 Category: Veterinary Research Authors: Cao Z, Zhang H, Yang Q, Zhang H, Fan G Tags: Am J Vet Res Source Type: research

Evaluation of relationships between results of electrocardiography and echocardiography in 341 chimpanzees (Pan troglodytes).
CONCLUSIONS AND CLINICAL RELEVANCE: Results indicated that relationships existed between ECG findings and cardiac morphology in the chimpanzees of the present study; however, further research is required to examine whether the predictive models generated can be modified to improve their clinical utility. PMID: 32436790 [PubMed - in process] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - May 23, 2020 Category: Veterinary Research Authors: Drane AL, Atencia R, Cooper SM, Feltrer Y, Calvi T, Strike T, Palmer C, Simcox S, Rodriguez P, Sanchez C, van Bolhuis H, Peck B, Eng J, Moittie S, Unwin S, Howatson G, Oxborough D, Stembridge MR, Shave RE Tags: Am J Vet Res Source Type: research

Effect of packed red blood cell transfusion on thromboelastographic tracings in dogs with naturally occurring anemia.
CONCLUSIONS AND CLINICAL RELEVANCE: Results indicated that pRBC transfusion had only small effects on the TEG tracings of hemodynamically stable dogs. Therefore, large changes in TEG tracings following pRBC transfusion are unlikely to be the result of the transfusion and should be investigated further. PMID: 32436791 [PubMed - in process] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - May 23, 2020 Category: Veterinary Research Authors: Brooks AC, Cooper ES, Couto CG, Guillaumin J Tags: Am J Vet Res Source Type: research

JAVMA News Digest.
Authors: PMID: 32436792 [PubMed - in process] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - May 23, 2020 Category: Veterinary Research Tags: Am J Vet Res Source Type: research

Effects of intra-articular administration of lidocaine, mepivacaine, and the preservative methyl parahydroxybenzoate on synovial fluid biomarkers of horses.
CONCLUSIONS AND CLINICAL RELEVANCE: Results suggested that mepivacaine was safer than lidocaine for intra-articular injection in horses. PMID: 32436793 [PubMed - in process] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - May 23, 2020 Category: Veterinary Research Authors: Adler DMT, Serteyn D, Franck T, Jørgensen E, Christophersen MT, Denwood M, Verwilghen DR Tags: Am J Vet Res Source Type: research

Comparison of the efficacy and duration of desensitization of oral structures following injection of various volumes of a lidocaine-bupivacaine mixture via an infraorbital approach in dogs.
CONCLUSIONS AND CLINICAL RELEVANCE: The volume of local anesthetic used for an infraorbital nerve block had no effect on block efficacy or duration. PMID: 32436794 [PubMed - in process] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - May 23, 2020 Category: Veterinary Research Authors: Pascoe PJ, Chohan AS Tags: Am J Vet Res Source Type: research

Evaluation of intramuscular injection of oxytetracycline for use as an experimental model to induce pain and assess the efficacy of pain mitigation strategies in dairy cows.
CONCLUSIONS AND CLINICAL RELEVANCE: IM injection of oxytetracycline in a hind limb reliably induced signs of pain in dairy cows and, with validation, might be useful as an experimental model for assessing pain mitigation strategies in cattle. PMID: 32436795 [PubMed - in process] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - May 23, 2020 Category: Veterinary Research Authors: Ohlheiser AL, Ahola JK, Baier FS, Callan RJ, Lear AS, Byers SR, Edwards-Callaway LN Tags: Am J Vet Res Source Type: research

Evaluation of various carbon dioxide laser settings on the time and number of laser beam passes required to make a full-thickness skin incision and amount of laser-induced tissue artifact.
CONCLUSIONS AND CLINICAL RELEVANCE: Results provided preliminary information regarding use of CO2 lasers to make skin incisions in veterinary patients. In vivo studies are necessary to evaluate the effect of various CO2 laser settings on tissue healing and patient outcome. PMID: 32436796 [PubMed - in process] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - May 23, 2020 Category: Veterinary Research Authors: Agulian LM, Mann FA, Middleton JR, Kim DY Tags: Am J Vet Res Source Type: research

Investigation of the effects of an ultraviolet germicidal irradiation system on concentrations of aerosolized surrogates for common veterinary pathogens.
CONCLUSIONS AND CLINICAL RELEVANCE: Results for some surrogates of veterinary pathogens suggested a potential benefit to supplementing manual disinfection practices with UVGI-based air cleaning systems in animal care environments. Further research is needed to investigate the utility of UVGI in operating HVAC systems. PMID: 32436797 [PubMed - in process] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - May 23, 2020 Category: Veterinary Research Authors: Pearce-Walker JI, Troup DJ, Ives R, Ikner LA, Rose JB, Kennedy MA, Verhougstraete MP Tags: Am J Vet Res Source Type: research

Randomized controlled trial to evaluate a novel two-catheter technique for urethral catheterization in anesthetized healthy female cats and small dogs.
Abstract OBJECTIVE: To evaluate a novel 2-catheter technique for urethral catheterization in female cats and small dogs and compare the time required for and success rates achieved by use of the novel technique versus traditional methods (blind technique in cats and digital palpation in dogs) as performed by personnel (catheter placers [CPs]) with different levels of experience in urinary catheter placement. ANIMALS: 39 healthy sexually intact female animals (24 cats and 15 dogs weighing
Source: American Journal of Veterinary Research - April 29, 2020 Category: Veterinary Research Authors: Abrams BE, Selmic LE, Howard J, Horvath SJ, Bednarski L, McLoughlin MA, Wavreille VA Tags: Am J Vet Res Source Type: research

Evaluation of subcutaneously administered electrolyte solutions in experimentally dehydrated inland bearded dragons (Pogona vitticeps).
CONCLUSIONS AND CLINICAL RELEVANCE: The changes in plasma glucose, sodium, and phosphorus concentrations and plasma osmolarity observed after SC administration of a single dose of RRS suggested this type of electrolyte solution should not be used for rehydration of bearded dragons. Rather, lactated Ringer solution or Plasma-Lyte A should be considered instead. PMID: 32343174 [PubMed - as supplied by publisher] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - April 29, 2020 Category: Veterinary Research Authors: Parkinson LA, Mans C Tags: Am J Vet Res Source Type: research

Efficacy and duration of effect for liposomal bupivacaine when administered perineurally to the palmar digital nerves of horses.
CONCLUSIONS AND CLINICAL RELEVANCE: Results suggested that liposomal bupivacaine is another option for perineural anesthesia in horses. Further research is necessary to determine the optimal dose and better elucidate the duration of effect for the drug when used for palmar digital nerve blocks in horses. PMID: 32343175 [PubMed - as supplied by publisher] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - April 29, 2020 Category: Veterinary Research Authors: McCracken MJ, Schumacher J, Doherty TJ, Sun X, Nichols CL, Olivarez J Tags: Am J Vet Res Source Type: research

F-wave parameters for the tibial nerve in Miniature Dachshunds with and without naturally acquired thoracolumbar intervertebral disk herniation.
CONCLUSIONS AND CLINICAL RELEVANCE: Mean F-wave duration was correlated with the severity of inhibitory motor tract dysfunction in the spinal cord of dogs. F-wave examination may be useful for objective functional evaluation of upper motor neurons in the spinal cord. PMID: 32343176 [PubMed - as supplied by publisher] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - April 29, 2020 Category: Veterinary Research Authors: Okuno S, Orito K Tags: Am J Vet Res Source Type: research

Effects of transrectal palpation with the fetal membrane slip technique for early pregnancy diagnosis on the proportion and type of associated pregnancy loss in dairy cattle.
CONCLUSIONS AND CLINICAL RELEVANCE: TRP with the FMS technique for early pregnancy diagnosis did not increase the prevalence of PL in dairy cattle or alert the proportion of type I versus type II PL. PMID: 32343177 [PubMed - as supplied by publisher] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - April 29, 2020 Category: Veterinary Research Authors: Romano JE, Thompson JA, Kraemer DC, Forrest DW Tags: Am J Vet Res Source Type: research

JAVMA New digest.
Authors: PMID: 32343178 [PubMed - as supplied by publisher] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - April 29, 2020 Category: Veterinary Research Tags: Am J Vet Res Source Type: research

Comparison of speed of onset and analgesic effect of 2% mepivacaine hydrochloride deposited within or outside the neurovascular bundle at the level of the proximal sesamoid bones in horses with naturally occurring forefoot-related lameness.
CONCLUSIONS AND CLINICAL RELEVANCE: Results suggested that when peripheral nerves of horses lie within a sheath, local anesthetic solution should be deposited within the sheath for an effective nerve block. If local anesthetic solution is deposited outside the sheath, the nerve block may yield erroneous results. PMID: 32343179 [PubMed - as supplied by publisher] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - April 29, 2020 Category: Veterinary Research Authors: Schumacher J, Cole RC, DeGraves FJ, Cofield LG Tags: Am J Vet Res Source Type: research

Evaluation of cell-free DNA as a diagnostic marker in cerebrospinal fluid of dogs.
CONCLUSIONS AND CLINICAL RELEVANCE: Although results indicated that the CSF cfDNA concentration could not be used to differentiate between categories of neurologic disease in dogs of the the present study, further investigation is warranted regarding the use of CSF analysis, including sequencing specific cfDNA mutations, for diagnosing and monitoring neurologic disease in dogs. PMID: 32343180 [PubMed - as supplied by publisher] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - April 29, 2020 Category: Veterinary Research Authors: Stark AC, McGrath S, Karn M, Thomson CE Tags: Am J Vet Res Source Type: research

Effectiveness of MB-102, a novel fluorescent tracer agent, for conducting ocular angiography in dogs.
Abstract OBJECTIVE: To evaluate the effectiveness of a novel fluorescence tracer agent, MB-102, for conducting ocular angiography in dogs. ANIMALS: 10 ophthalmologically normal dogs (2 to 4 years old) and 10 dogs with retinal degeneration or primary open-angle glaucoma (
Source: American Journal of Veterinary Research - April 29, 2020 Category: Veterinary Research Authors: Pirie CG, Rogers TE, Dorshow RB Tags: Am J Vet Res Source Type: research

Radiographic localization of the attachments of soft tissue structures in the tarsal region of horses.
CONCLUSIONS AND CLINICAL RELEVANCE: Results indicated that attachments of soft tissue structures in the tarsal region of horses were in distinct radiographically identifiable locations and that visualization of individual soft tissue attachments could be optimized with certain radiographic views, including some nonstandard views. PMID: 32343182 [PubMed - as supplied by publisher] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - April 29, 2020 Category: Veterinary Research Authors: Casillas JM, Jacobs CC, Manfredi JM Tags: Am J Vet Res Source Type: research