Non-adherence to Treatment Among Iranian Dialysis Patients, A Systematic Review.
This study aims at detecting the most important causes of Non-adherence in patients on dialysis according to previous studies. First, all of the studies related to our title were searched using main keywords (dialysis, hemodialysis, adherence, and non-adherence) for English and Persian databases; Iranmedex, Magi ran, SID, Iran doc, Google, Google scholar, PubMed, Embase, CINAHL, PsycInfo, and Cochrane Database of Systematic that covering the period from 2010 to 2018 was reviewing following a predefined inclusion and exclusion criteria. As a result, 40 papers related to inclusion and exclusion criteria were identified and a...
Source: Iranian Journal of Kidney Diseases - December 29, 2019 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Ask-Upmark Kidney, Imaging Features.
We describe the classical imaging findings of a child with secondary hypertension which was due to hypoplasia of a renal segment. PMID: 31880582 [PubMed - in process] (Source: Iranian Journal of Kidney Diseases)
Source: Iranian Journal of Kidney Diseases - December 29, 2019 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

The Role of Urinary Angiotensinogen in Kidney Interstitial Inflammation and Renal Prognosis.
Authors: Dou Y, Song D, Wang C, Liu D, Cheng G, Xiao J, Zhao Z Abstract INTRODUCTION: Urinary angiotensinogen (uAGT) has been described as a novel biomarker of acute kidney injury (AKI) and chronic kidney disease (CKD). Renal interstitial inflammatory cell infiltration is a common renal pathological feature of AKI and CKD. However, the correlation between uAGT and renal interstitial inflammatory cell infiltration is unknown. The aim of this study was to analyze the expression of uAGT, its relationship with interstitial inflammatory cell infiltration, and prognosis in patients with renal insufficiency. METHODS: ...
Source: Iranian Journal of Kidney Diseases - December 29, 2019 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Stem Cell Therapy Ameliorates Ischemia-reperfusion Induced Kidney Injury After 24 Hours Reperfusion.
In this study 28 male Wistar rats were divided into four groups of control, sham, I/R24h+PBS, and I/R24h+AD-MSC. Blocking the renal arteries for 45 minutes induced renal I/R and then reperfusion was conducted for 24 hours. Parameters including urine volume, osmolarity, plasma creatinine (Crp), and blood urea nitrogen (BUN) were evaluated and values of creatinine clearance (CCr), absolute sodium excretion (UNaV°), fractional excretion of sodium (FENa), absolute potassium excretion (UKV°) and fractional excretion of potassium (FEK) were calculated. The right kidney was removed to measure the malondialdehyde (MDA) and...
Source: Iranian Journal of Kidney Diseases - December 29, 2019 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Serum Levels of CXCL10 and Vitamin D in Patients with Lupus Nephritis.
Authors: Abediazar S, Jafari-Nakhjavani M, Ghorbanihaghjo A, Shekarchi M, Zununi Vahed S Abstract INTRODUCTION: Kidney involvement is a hallmark of systemic lupus erythematosus (SLE) and evaluation of its inflammatory response is demanding. It was the aim of the present study to evaluate the levels of CXCL10 and vitamin D in serum samples of cases with active lupus nephritis (LN). METHODS: Fifty lupus patients were enrolled in our study, 25 patients had lupus nephritis and 25 patients were without evidence of LN. Thirty-nine healthy subjects were also participated as a control group. Complete biochemical and se...
Source: Iranian Journal of Kidney Diseases - December 29, 2019 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Duration of Vascular Access Usage and Patient Survival in the First Year of Hemodialysis.
CONCLUSION: Our results presented that regardless of the type of initial vascular access, limiting the length of the time using CVC as well as switching to AVF could significantly improve the survival of HD patients. PMID: 31880586 [PubMed - in process] (Source: Iranian Journal of Kidney Diseases)
Source: Iranian Journal of Kidney Diseases - December 29, 2019 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Dominance of Variant Human Herpesvirus 6 A Among Hemodialysis Patients, Ahvaz, Iran.
Authors: Mahmoudvand S, Shokri S, Nahid-Samiei R, Kaydani GA, Makvandi M, Jalilian S, Shahbazian H, Shayanpour S, Makvandi K, Pirmoradi R Abstract INTRODUCTION: Hemodialysis (HD) patients are a high-risk population for acquiring blood-borne viruses such as HHV-6. HHV-6 can remain latent in the host cells after primary infection; the reactivation of virus may result complications such as seizure, respiratory failure, hepatitis, and encephalitis. There is a limited report concerning HHV-6 infection in HD patients in Iran. Thus, this study was conducted to determine the frequency of HHV-6 among HD patients. METHOD...
Source: Iranian Journal of Kidney Diseases - December 29, 2019 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Association Between CYP3A5 Genetic Polymorphisms with Tacrolimus Dose Requirement and Allograft Outcomes in Iranian Kidney Transplant Recipients.
This study assessed the relationship between CYP3A5/3A4 polymorphisms and tacrolimus dose requirement as well as 6-month transplant outcomes in Iranian kidney transplant recipients. METHODS: In this prospective study, 110 adult kidney transplant recipients treated with tacrolimus were genotyped for the presence of common SNPs: rs776746: A> G (CYP3A5*3). Patients who carried at least one CYP3A5*1 allele were known as CYP3A5 expressers while those who were CYP3A5*3/*3 homozygotes were classified as CYP3A5 non-expressers. RESULTS: The daily tacrolimus dose was significantly higher and tacrolimus dose adjusted troug...
Source: Iranian Journal of Kidney Diseases - December 29, 2019 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Sheehan syndrome with Gitelman syndrome, Tackling Additive Morbidity.
We report the case of a middle-aged woman with both these conditions, resulting in management issues. Physicians encountering unexplained hypokalemia refractory to standard management must consider the possibility of renal tubular disorders. PMID: 31880589 [PubMed - in process] (Source: Iranian Journal of Kidney Diseases)
Source: Iranian Journal of Kidney Diseases - December 29, 2019 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Pharmacist-Physician Organic Cooperation Is an Effective Strategy to Reduce the Medication-related Problems, An Experience in CKD Patients.
Authors: Esamily H, Adl F, Saffaei A, Ziaie S PMID: 31880590 [PubMed - in process] (Source: Iranian Journal of Kidney Diseases)
Source: Iranian Journal of Kidney Diseases - December 29, 2019 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

The role of immune response in initiation and progression of chronic kidney disease.
Authors: Shahbazi M, Smailnejad Ganji K, Mirzakhani M, Mohammadnia-Afrouzi M, Akbari R Abstract Chronic kidney disease (CKD) is a common disease in the world that has adverse outcomes.  Immune systems and its components have important roles in the initiation, progression and complications of this disease by systemic inflammation.  Regarding the role of kidneys in the body's natural homeostasis and its relationship with other organs, CKD causes impairments in other organs. Patients with chronic renal failure have variety of complications, such as cardiovascular disease, anemia, bone disorders, immune dysfu...
Source: Iranian Journal of Kidney Diseases - November 12, 2019 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Percutaneous biopsy of kidney; comparison between prone position and sitting position.
CONCLUSION: In comparison with the prone position, kidney biopsy at sitting position is more comfortable at least for patients who seems couldn't tolerate prone position. We recommend sitting position for kidney biopsy owing to the low side effects rate of this diagnostic technique. PMID: 31705745 [PubMed - in process] (Source: Iranian Journal of Kidney Diseases)
Source: Iranian Journal of Kidney Diseases - November 12, 2019 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

The effect of curcumin in prevention of contrast nephropathy following coronary angiography or angioplasty in CKD patients.
Conclusion: It is appeared prophylactic oral Curcumin hasn't protective effects on CIN in high risk patients who have undergone coronary procedure. PMID: 31705746 [PubMed - in process] (Source: Iranian Journal of Kidney Diseases)
Source: Iranian Journal of Kidney Diseases - November 12, 2019 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Risk factors analysis for acute kidney injury in the newborn infants: predictive strategies.
Authors: Mazaheri M, Rambod M Abstract INTRODUCTION: Acute kidney injury (AKI) in the newborn infants is associated with increased mortality and morbidity. The purpose of this study was to investigate the prevalence, risk factors and outcome of AKI in the premature neonates. METHODS: Between January 2014 and January 2015, 206 premature neonates between 27 and 36 weeks gestations were studied in the newborn intensive care unit of Amir-AL Momenin Hospital, in Semnan, Iran. All neonates were followed-up for seven days after birth. The diagnosis of AKI was based on urine output (UOP) 0.3 mg/dL or increased by 150% ...
Source: Iranian Journal of Kidney Diseases - November 12, 2019 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Genetics and outcome of atypical hemolytic-uremic syndrome in Turkish children: a retrospective study between 2010 and 2017, a single-center experience.
CONCLUSIONS: Morbidity rate is higher in children with aHUS. The renal prognosis and morbidity rate is higher in children with CFH mutations than other children with aHUS. Poor prognosis in aHUS children with CFH mutation depends on the genetic background. PMID: 31705748 [PubMed - in process] (Source: Iranian Journal of Kidney Diseases)
Source: Iranian Journal of Kidney Diseases - November 12, 2019 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Tacrolimus can induce remission in cyclosporine and mycophenolate mofetil resistant pediatric onset nephrotic syndrome.
Conclusions: Tacrolimus is effective in treating refractory multi-drug resistant NS with favorable outcomes in childhood onset NS. PMID: 31705749 [PubMed - in process] (Source: Iranian Journal of Kidney Diseases)
Source: Iranian Journal of Kidney Diseases - November 12, 2019 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Effect of Chronic Kidney Disease on Cardiovascular Events: An Epidemiological Aspect from SPRINT Trial.
Authors: Attar A, Sayadi M Abstract INTRODUCTION: Currently, conflicting evidence exists among community-based studies as to whether Chronic kidney disease (CKD) is a Cardiovascular (CVD) risk equivalent. We aimed to evaluate the effect of CKD on CVD based on large trial results. METHODS: To perform a secondary analysis, we obtained the data of SPRINT trial from NHLBI Data Repository Center. 2646 subjects with baseline CKD and 6715 without CKD were enrolled. A composite of myocardial infarction, other acute coronary syndromes, stroke, heart failure, or death from cardiovascular causes was considered as primary ...
Source: Iranian Journal of Kidney Diseases - November 12, 2019 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

An unusual case of familial systemic lupus erythematosus with distal renal tubular acidosis and hemolytic anemia.
We report an adolescent girl with SLE, autoimmune thyroiditis and distal RTA who subsequently developed autoimmune hemolytic anemia. During a follow up of almost 7 years the girl never developed any proteinuria while the RTA persisted. Also during this period her mother was also diagnosed with SLE manifesting as thrombocytopenia. PMID: 31705751 [PubMed - in process] (Source: Iranian Journal of Kidney Diseases)
Source: Iranian Journal of Kidney Diseases - November 12, 2019 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Acute renal failure due to IgA nephropathy in sarcoidosis.
We presented a 56-year-old woman with renal impairment who was diagnosed with sarcoidosis accompanied by IgA nephropathy. Treatment with methylprednisolone was started for the patient. After treatment, the patient was discharged with good general condition and resolved proteinuria. PMID: 31705752 [PubMed - in process] (Source: Iranian Journal of Kidney Diseases)
Source: Iranian Journal of Kidney Diseases - November 12, 2019 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

The Neglected fact:Anticoagulation-Related Nephropathy.
This article discussed the research progress and controversial topics of anticoagulation-related nephropathy, and this disease is valued which be paid attention to. PMID: 31705753 [PubMed - in process] (Source: Iranian Journal of Kidney Diseases)
Source: Iranian Journal of Kidney Diseases - November 12, 2019 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Comment on: Efficacy and Safety of Mycophenolate Mofetil versus Intravenous Pulse Cyclophosphamide as Induction Therapy in Proliferative Lupus Nephritis.
Authors: Ziaie S, Moradi O, Saffaei A PMID: 31705754 [PubMed - in process] (Source: Iranian Journal of Kidney Diseases)
Source: Iranian Journal of Kidney Diseases - November 12, 2019 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Utilization of Mesenchymal Stem Cells in Kidney Transplantation: From Bench to Bedside.
Authors: Saidi RF, Moghadasali R, Shekarchian S Abstract There has been ample of preclinical and animal studies whichshowed efficacy and safety of using mesenchymal stem cells (MSCs)after transplantation for tissue repair, immunosuppression ortolerance induction. However, there has been a significant progressrecently using MSCs in small clinical trials after transplantation. Recent results using MSCs after transplantation seem to befeasible and safe. However, there are some limitations to show theeffectiveness of these cells including source, dose, timing and routeof infusions. Currently, live donor kidney transpla...
Source: Iranian Journal of Kidney Diseases - August 21, 2019 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

The Relationship Between Serum Level of 25-hydroxy Vitamin D and Cytomegalovirus Infection in Kidney Transplant Recipients.
CONCLUSION: Although we did not find a statistically significantrelationship between vitamin D levels and the CMV infection, CMVinfected patients had lower vitamin D level compared with noninfectedrecipients, hence vitamin D deficiency can be consideredas a risk factor for CMV reactivation after renal transplantation. PMID: 31422387 [PubMed - in process] (Source: Iranian Journal of Kidney Diseases)
Source: Iranian Journal of Kidney Diseases - August 21, 2019 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Macrophage Migration Inhibitory Factor -173 G > C Gene Polymorphism Is Associated with Increased Risk of Nephrotic Syndrome in Children.
CONCLUSION: In summary, the results indicated that MIF -137 G>Cis significantly associated with increased risk of NS. More studieswith larger sample size among different ethnicities are needed toverify our findings. PMID: 31422388 [PubMed - in process] (Source: Iranian Journal of Kidney Diseases)
Source: Iranian Journal of Kidney Diseases - August 21, 2019 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Diagnostic and Prognostic Values of Antinuclear Immunoglobulin G in Pediatric Lupus Patients.
Authors: El-Gamasy MA, Elbendary A Abstract INTRODUCTION: Systemic lupus erythematous (SLE) as an autoimmunedisease caused by self immunoglobulin. It was proposed thatthe chromatin including nucleosomes is the main antigen inthe pathogenesis of SLE, and that antinuclear immunoglobulinG are associated with disease activity. Aim of the study was tostudy the diagnostic and prognostic value of serum levels ofantinuclear immunoglobulin G as the most famous anti-chromatinimmunoglobulin as a diagnostic tool and a disease activity markerin juvenile systemic lupus erythematous. METHODS: The work was conducted on 90 pedi...
Source: Iranian Journal of Kidney Diseases - August 21, 2019 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Assessment the Effect of Dexamethasone on Urinary Cytokines and Renal Scar in Children with Acute Pyelonephritis.
Authors: Ghaffari J, Mohammadjafari H, Mohammadi GH, Mahdavi MR Abstract INTRODUCTION: One of the most serious complications of acute febrilepyelonephritis in children is the development of renal scar. Thisstudy aimed to investigate the effect of dexamethasone on urinarycytokine levels and renal scar in children with acute pyelonephritis. METHODS: In a double-blind randomized clinical trial, 60 childrenaged 3 months to 12 years with acute febrile pyelonephritis enrolled.The experimental group was treated with a combination of antibioticand dexamethasone, and the control group underwent treatmentwith antibiotic ...
Source: Iranian Journal of Kidney Diseases - August 21, 2019 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Management of Idiopathic Retroperitoneal Fibrosis, a Retrospective Study at Prince Hussein Urology and Organ transplantation center (PHUO), Jordan.
CONCLUSION: Glucocorticoids is the the mainstay of treatment. Therenal function tests, of the vast majority of patients, normalizedwith treatment. Relapse may occur, so a follow-up over a longperiod of time is required. A high index of suspicion is neededfor diagnosis in asymptomatic patients. PMID: 31422391 [PubMed - in process] (Source: Iranian Journal of Kidney Diseases)
Source: Iranian Journal of Kidney Diseases - August 21, 2019 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Effect of Low Dose Imipramine in Patients with Nocturnal Enuresis, A Randomized Clinical Trial.
Authors: Ravanshad Y, Azarfar A, Esmaeeli M, Mostafavian Z, Zahabi E, Ravanshad S Abstract INTRODUCTION: Nocturnal enuresis is a condition, which can affectthe quality of life in children. The present study was designed toinvestigate the efficacy of low-dose imipramine combined withdesmopressin on treatment of patients with primary nocturnalenuresis who were defined as desmopressin non-responders. METHODS: A randomized clinical trial was carried out on patientswith primary nocturnal enuresis. Forty children with enuresisranging from 5 to 12 years old were randomly divided into theintervention (n = 20) and contr...
Source: Iranian Journal of Kidney Diseases - August 21, 2019 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Investigating the Relationship Between Blood Pressure and Serum FGF23 Level in Patients Undergoing Hemodialysis in Guilan Province, A Cross Sectional Study.
CONCLUSION: We suggest that understanding relationship betweenphosphate, FGF23 and cardiovascular disease can be applied intargeted phosphate-based treatment. Kidney failure and the nondippercondition may be highly related to one another and leadto ESRD. Therefore, a special investment in controlling bloodpressure and examining it with a tool such as ABPM can greatlyhelp patients to progress effectively. PMID: 31422393 [PubMed - in process] (Source: Iranian Journal of Kidney Diseases)
Source: Iranian Journal of Kidney Diseases - August 21, 2019 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Dietary Intake and Its Related Factors in Peritoneal Dialysis Patients in Tehran, Iran.
Authors: As'habi A, Najafi I, Tabibi H, Hedayati M Abstract INTRODUCTION: Poor nutritional status is prevalent in peritonealdialysis (PD) patients and is related to morbidity and mortality.Therefore, the aim of the present study was to assess the dietaryintake and its related factors in PD patients in Tehran, Iran. METHODS: All eligible PD patients in Tehran peritoneal dialysiscenters were included in this cross-sectional study. Dietary intakeof PD patients was determined using a 3-day dietary recall. Also,a 4 mL blood sample was obtained from each patient to measureserum biochemical parameters. RESULTS: In...
Source: Iranian Journal of Kidney Diseases - August 21, 2019 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Trimethoprim-sulfamethoxazole Induced Hyponatremia and Hyperkalemia, The Necessity of Electrolyte Follow-up in Every Patient.
Authors: Khorvash F, Moeinzadeh F, Saffaei A, Hakamifard A Abstract Trimethoprim-sulfamethoxazole (TMP/SMX) is a bactericidalantibiotic. The most common adverse effect of TMP/SMX is skinrashes and gastrointestinal symptoms. Although hyperkalemia canoccur with TMP/SMX component but hyponatremia is uncommon. A55- year old woman, known case of rheumatoid arthritis, presentedwith fever and mild dyspnea. According to diagnostic work upthe infection with pneumocystis jirovecii was confirmed. TMP/SMX was started but after 10 days the patient acutely representedwith nausea and became lethargic. The laboratory studies showe...
Source: Iranian Journal of Kidney Diseases - August 21, 2019 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Impact of Standard Preservation on Renal Transplantation Outcome.
Authors: Heidary Rouchi A PMID: 31422396 [PubMed - in process] (Source: Iranian Journal of Kidney Diseases)
Source: Iranian Journal of Kidney Diseases - August 21, 2019 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

The Prevalence of Shiga Toxin-producing Escherichia Coli in Patients with Gastroenteritis in Iran, Systematic Review and Meta-analysis.
Authors: Hooman N, Khodadost M, Ahmadi A, Nakhaie S, Nagh Shizadian R Abstract Shiga toxin induced Escherichia Coli (STEC) is associated with chronic kidney disease or neurologic disability. The aim of this study is to determine the prevalence of STEC identified in human studies in Iran. Search engines of PubMed, EMBASE, OVID, SCOPUS, Web of Science, Google Scholar, IranMedex, MagIran, SID and ganj.irandoc were used. All human studies with stool or rectal swap samples evaluated for STEC and the outcome of HUS in Iran, which had been published between 1985 and 2017, were included. Chi-square and I2 statistic tests w...
Source: Iranian Journal of Kidney Diseases - June 19, 2019 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Tiny Non-coding RNAs in Body Fluids, Possible Biomarkers for Autosomal Dominant Polycystic Kidney Disease.
Authors: Ghasemi Y, Tayebi-Khosroshahi H, Abedi B, Rahmati-Yamchi M, Alizadeh E Abstract The functional and structural disease with autosomal dominant inheritance (ADPKD) shows a poly cystic nature is described by the presence of epithelial cysts in the human renal parenchyma. There are no standard and reliable biomarkers for the detection of ADPKD in early stages which delays the therapeutic approaches. Ideal biomarkers of ADPKD, should have high sensitivity, specificity, and excellent association with disease pathogenesis and development. Both in vitro cellular and in vivo studies on animal models proved the sign...
Source: Iranian Journal of Kidney Diseases - June 19, 2019 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Molecular Genetic Analysis of Steroid Resistant Nephrotic Syndrome, Detection of a Novel Mutation.
CONCLUSION: It seems that NPHS2, especially exons 4 and 5, should be considered as the first step in genetic evaluation of Iranian patients. We suggest conducting WES after NPHS2 screening to identify the potential genes associated with SRNS, Further studies are required to examine more common genes in the first step and then designing native laboratory panels. PMID: 31209189 [PubMed - in process] (Source: Iranian Journal of Kidney Diseases)
Source: Iranian Journal of Kidney Diseases - June 19, 2019 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Levels and Clinical Significances of Glypican-5 in Urine of Type 2 Diabetic Nephropathy Cases.
CONCLUSION: Urinary glypican-5 was specifically elevated in type 2 diabetes patients with DN and it was associated with disease progression. Urinary glypican-5 may serve as a useful non-invasive marker for the progression of DN. PMID: 31209190 [PubMed - in process] (Source: Iranian Journal of Kidney Diseases)
Source: Iranian Journal of Kidney Diseases - June 19, 2019 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Prevention of Contrast-induced Nephropathy in Patients with Chronic Kidney Disease Undergoing Elective Coronary Angioplasty or Angiography with Sodium Potassium Citrate Solution, a Double Blind Randomized Clinical Trial.
Authors: Ghorbani A, Yazdankhah S, Adel MH, Tabesh H, Sattari AR, Sattari SA, Heybar H, Madjidi S Abstract INTRODUCTION: Contrast-induced nephropathy (CIN) is a frequent complication of contrast exposure. A recent study suggested that Na/K citrate might have a preventive role. We investigated the efficacy of Na/K citrate to prevent CIN in patients with renal dysfunction undergoing coronary intervention. METHODS: The randomized, double-blind, placebo-controlled trial included 201 patients with estimated creatinine clearance .05). Post-exposure Cr values were not significantly different between the two groups (1....
Source: Iranian Journal of Kidney Diseases - June 19, 2019 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Preventive Effect of Trimetazidine on Contrast-Induced Acute Kidney Injury in CKD Patients Based on Urinary Neutrophil Gelatinase-associated Lipocalin (uNGAL): A randomized Clinical Trial.
Authors: Mirhosseni A, Farahani B, Gandomi-Mohammadabadi A, Keyvani H, Biglari-Abhari M, Davari A, Vazirizade-Mahabadi MH, Savaj S Abstract INTRODUCTION: Contrast-induced Acute Kidney Injury (CI-AKI) is a prevalent complication of chronic kidney disease (CKD) patients. The aim of this study was to evaluate the effects of periprocedural administration of trimetazidine as an anti-oxidant agent on the incidence of CI-AKI in CKD patients based on changes of Neutrophil Gelatinase-Associated Lipocalin (uNGAL) level, which has recently been introduced as an early predictor of CI-AKI. METHODS: One hundred CKD patients ...
Source: Iranian Journal of Kidney Diseases - June 19, 2019 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Plasma levels of miR-21, miR-150, miR-423 in patients with lupus nephritis.
Authors: Nakhjavani M, Etemadi J, Pourlak T, Mirhosaini Z, Zununi Vahed S, Abediazar S Abstract INTRODUCTION: MicroRNAs (miRNA) are involved in the pathogenesis of systemic lupus erythematosus (SLE), an autoimmune disease, and can be considered as diagnostic and prognostic biomarkers. Lupus nephritis (LN) remains a major challenge of SLE since it damages the kidneys in the course of the disease. METHODS: The aim of this study was to investigate the diagnostic values of circulating miR-21, miR-148a, miR-150, and miR-423 involved in autoimmunity and kidney fibrosis in plasma samples of LN cases (N = 26) and healt...
Source: Iranian Journal of Kidney Diseases - June 19, 2019 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Systemic Sclerosis with Focus on Scleroderma Renal Crisis.
This report has basically focused on scleroderma renal crisis (SRC), which is the most serious renal manifestation of SSc, characterized by renal failure and sudden onset of hypertension. A 44-year-old man was hospitalized with hypertension, headache, vertigo, nausea, rhinorrhea, reflux, dysphagia, dyspnea (Fc II), visual impairment, mechanical arthralgia, and edema (+3) accompanied by a rare skin lesion. Raynaud's phenomenon was also remarkable in fingers and toes. According to signs and symptoms, SSc diagnosed and the proper treatment was applied. It is of great importance that in the case of malignant hypertension in pa...
Source: Iranian Journal of Kidney Diseases - June 19, 2019 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Dr Bijan Nikakhtar's Biography.
Authors: Broumand B PMID: 30988243 [PubMed - in process] (Source: Iranian Journal of Kidney Diseases)
Source: Iranian Journal of Kidney Diseases - April 18, 2019 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Analyzing Mitochondrial Dysfunction, Oxidative Stress, and Apoptosis: Potential Role of L-carnitine.
Authors: Modanloo M, Shokrzadeh M Abstract Mitochondrial dysfunction, apoptosis and oxidative stress, are the interrelated events underlining the pathology of  numerous diseases including cardiovascular, neurologic, and metabolic disorders. Due to playing a critical role in glucose and fatty acids' metabolism, L-carnitine probably has the potential to adjust these unfavorable events. The present review has evolved based on existing literature that investigated the mechanisms of L-carnitine and its derivatives based mitochondrial dysfunction, oxidative stress, and apoptosis related modulation. The released stud...
Source: Iranian Journal of Kidney Diseases - April 18, 2019 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Key Genes and Signaling Pathways Contribute to the Pathogensis of Diabetic Nephropathy.
CONCLUSION: BMP7, CD55, CSF1R, INHBC and F5 are likely to take crucial roles in the pathogenesis of DN. PMID: 30988245 [PubMed - in process] (Source: Iranian Journal of Kidney Diseases)
Source: Iranian Journal of Kidney Diseases - April 18, 2019 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Ferric Citrate Attenuates Cardiac Hypertrophy and Fibrosis in a Rat Model of Chronic Kidney Disease.
CONCLUSIONS: Treatment with ferric citrate attenuated renal failure and cardiovascular abnormalities including myocardial hypertrophy and fibrosis in CKD rats. PMID: 30988246 [PubMed - in process] (Source: Iranian Journal of Kidney Diseases)
Source: Iranian Journal of Kidney Diseases - April 18, 2019 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Platelet Activation and Inflammation in Hypertensive Children with Non-dipper and Dipper Status.
In this study, we aimed to investigate the association between ambulatory blood pressure monitoring (ABPM) values and inflammation with platelet indices in children with dipper and non-dipper hypertension. MATERIALS AND METHODS: A total of 153 patients who underwent ABPM were included in this retrospective study. The participants were divided into three groups (61 non-dipper hypertensive, 28 dipper hypertensive, 64 normotensive). Neutrophil and platelet count, neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), mean platelet volume (MPV), plateletcrit (PCT), and platelet distribution width (PDW) w...
Source: Iranian Journal of Kidney Diseases - April 18, 2019 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Effect of Dialysate Glucose Concentration on Hepcidin Clearance in Maintenance Hemodialysis Patients.
Authors: Zou LX, Sun L, Deng N, Sun L, Han YC Abstract INTRODUCTION: Hepcidin is a key regulator of iron homeostasis, takes part in pathophysiology of anemia and cardiovascular disease in maintenance hemodialysis (MHD) patients. The aim of this study was to compare the effect of glucose-free and glucose-containing dialysate on the clearance of hepcidin-25 during a hemodialysis (HD) session and discuss its potential mechanism in MHD patients. METHODS: In a longitudinal interventional study of 30 stable MHD patients without diabetes, we measured serum hepcidin-25 and plasma catecholamines (adrenaline, noradrenali...
Source: Iranian Journal of Kidney Diseases - April 18, 2019 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Cardiac Biomarkers and Cardiovascular Outcome in Children with Chronic Kidney Disease.
CONCLUSIONS: Elevated H-FABP and PAPP-A are valuable prognostic markers for cardiovascular outcome in CKD children on regular hemodialysis. PMID: 30988249 [PubMed - in process] (Source: Iranian Journal of Kidney Diseases)
Source: Iranian Journal of Kidney Diseases - April 18, 2019 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Acute Kidney Injury Following Usage of Formaldehyde-Free Hair Straightening Products.
Authors: Ahmed HM, Rashad SH, Ismail W Abstract Acute kidney injury is manifested by sudden deterioration of kidney functions, with or without reduction of urine output. The spectrum of injury ranges from mild to severe, sometimes requires renal replacement therapy. The initial workup includes a patient history to identify the use of nephrotoxic medications or systemic illnesses that may cause poor renal perfusion or directly impair renal function. Formaldehyde which present in cosmetic products; is toxic to many parts including respiratory, renal, and neurologic systems. Here, we have reported 2 cases of acute kid...
Source: Iranian Journal of Kidney Diseases - April 18, 2019 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

A Rare Case of Acute Kidney Injury: McKittrick Wheelock Syndrome.
Authors: Guney I, Burgucu HC, Ergul F, Hasirci I, Omeroglu E Abstract McKittrick-Wheelock syndrome is a rare complication of rectosigmoid villous adenoma leading to secretory diarrhea, prerenal acute kidney injury and severe fluid and electrolyte imbalances. There are about 50 cases reported in literature. We represent a case of 71 year-old patient with persistant chronic diarrhea, prerenal azotemia, severe hypokalemia, and hyponatremia. Initially, the patient's kidney function and serum potassium values were normalized by conservative treatment, and villous adenoma was removed by surgery. PMID: 30988251 [PubMe...
Source: Iranian Journal of Kidney Diseases - April 18, 2019 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Rituximab to Abbreviate Plasma Exchange in Anti-CFH (Complement Factor H) Antibody Mediated Atypical HUS.
Authors: Mittal A, Dijoo M, Aggarwal S, Gulati S Abstract While terminal complement blockade with Eculizumab is the first line therapy for atypical HUS (Haemolytic uremic syndrome), lack of its availability and cost limits its use. Plasma exchange becomes a first line modality in the current scenario. However, exposure to large volumes of allogenic plasma and lack of skilled manpower are the limiting factors associated with it. Moreover, there is a subset of patients who fail to respond to plasma exchange. Treatment and follow up records of the children with atypical HUS who did not respond to daily plasma exchange...
Source: Iranian Journal of Kidney Diseases - April 18, 2019 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research