COVID-19 and the Kidneys, Implications and Outcomes.
Authors: Goel N, Jain D, Haddad DB Abstract Coronavirus disease (COVID-19), declared as a pandemic has affected millions of people and caused unprecedented number of death. The disease is caused by a severe acute respiratory syndrome related coronaviruses-2 virus which enters cells by binding with the host angiotensin converting enzyme-2 and CD147 protein. Among COVID-19 patients admitted to a hospital, hypertension, diabetes and obesity are the most common co-morbidities. A majority of COVID-19 hospitalized patients are found to have proteinuria and hematuria which is associated with higher risk of in-hospital mor...
Source: Iranian Journal of Kidney Diseases - January 27, 2021 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Association Between Serum Lipid Levels and Estimated Glomerular Filtration Rate in Type 2 Diabetic Patients.
Authors: Samimagham HR, Barghak M, Kazemi Jahromi M Abstract INTRODUCTION: Dyslipidemia is a common metabolic abnormality in Type 2 diabetic Mellitus (T2DM) patients with kidney dysfunction. Therefore, the current study was conducted to assess the association between serum lipid levels and estimated glomerular filtration rate (eGFR) in T2DM patients. METHODS: This cross-sectional study was performed on 802 participants, aged 40 years or more who had referred to the Abu Reyhan Clinic of Shahid Mohammadi Hospital in Bandar Abbas, Hormozgan province, Iran. Biochemical variables including FBS, triglycerides, total ...
Source: Iranian Journal of Kidney Diseases - January 27, 2021 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Hypertension and Decreased Glomerular Filtration Rate Among Commercial Drivers.
Authors: Mousavi Movahed SM, Akbarpour S, Saraei M, Mahboobi M, Najafi A, Taghizadadeh F Abstract INTRODUCTION: Chronic Kidney Disease (CKD) is of high clinical importance due to cost of outcomes such as kidney transplantation. However, CKD is an overlooked disorder among commercial drivers. The present study aimed to evaluate hypertension and Glomerular Filtration Rate (GFR) among commercial drivers. METHODS: In this cross-sectional study, a total of 903 commercial drivers referred for obtaining their health license were recruited. After obtaining informed consent, a questionnaire consisted of demographic char...
Source: Iranian Journal of Kidney Diseases - January 27, 2021 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Metabolic and Anti-inflammatory Response to Melatonin Administration in Patients with Diabetic Nephropathy.
This study was performed to analyze the effects of melatonin administration on metabolic status in patients with DN. METHODS: This randomized, double blind, placebo-controlled clinical trial was performed on 60 patients with DN. Patients were randomly assigned into two groups to take either 10 mg/d of melatonin (n = 30) or placebo (n = 30) for 12 weeks. Fasting blood samples were taken at baseline and 12 weeks after intervention to quantify metabolic parameters. RESULTS: Melatonin administration significantly reduced plasma fasting glucose (β = -10.64 mg/dL; 95% CI: -20.37 to -0.90; P
Source: Iranian Journal of Kidney Diseases - January 27, 2021 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Evaluation of 25-hydroxy Vitamin D and 1,25-dihydroxy Vitamin D Levels in Maintenance Hemodialysis Patients.
Authors: Lotfollahi L, Ossareh S, Neyestani TR Abstract INTRODUCTION: Dysregulated vitamin D metabolism is one of the most important issues in chronic kidney disease- mineral and bone disorder (CKD-MBD). Patients with end-stage kidney disease (ESKD) receive large amounts of calcitriol, i.e., 1,25 -dihydroxy vitamin D [1-25(OH)2D], for suppression of parathyroid hormone (PTH). The aim of this study was to evaluate the 1-25(OH)2D status in maintenance hemodialysis patients and its correlation with 25(OH) D level and calcitriol consumption and to determine whether the usual practice of administrating large amounts of ...
Source: Iranian Journal of Kidney Diseases - January 27, 2021 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Evaluation of Antipruritic Effect of Melatonin on Hemodialysis Patients with Uremic Pruritus, A Double-Blind, Randomized, Crossover Trial.
CONCLUSION: Based on to the preliminary results of this study, melatonin can be introduced as an effective drug for management of pruritus in uremic patients. PMID: 33492303 [PubMed - in process] (Source: Iranian Journal of Kidney Diseases)
Source: Iranian Journal of Kidney Diseases - January 27, 2021 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Effect of Parathyroid Hormone on Intestinal Mucosal Sodium Dependent Phosphorus Transporter.
CONCLUSION: A high PTH level decreases the protein expression of NPT-2b and Pit-1 in the intestinal mucosa. PMID: 33492304 [PubMed - in process] (Source: Iranian Journal of Kidney Diseases)
Source: Iranian Journal of Kidney Diseases - January 27, 2021 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Risk Factors for Development of PAD in PD Patients.
Authors: Wang X, Teng Q, Zhu L Abstract INTRODUCTION: To explore the risk factors for development of peripheral arterial disease (PAD) in patients with maintenance peritoneal dialysis and the relationship between osteoprotegerin (OPG) and PAD. METHODS: In China, 108 patients with PD were selected as the research subjects. General information such as age, gender, height, weight, BMI, blood pressure, and smoking history were collected. Serum albumin, fasting glucose, calcium, phosphorus, blood urea nitrogen, creatinine, total cholesterol, triglyceride, LDL-c, HDL-c and CRP, OPG levels were detected. Urea clearanc...
Source: Iranian Journal of Kidney Diseases - January 27, 2021 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Renal Lymphangiomatosis Mimicking Polycystic Kidney Disease In An Adult, A Case Report and Literature Review.
We report a case of renal lymphangiomatosis, previously diagnosed as autosomal dominant polycystic kidney disease, to emphasize that these two diseases can be easily confused. It should be kept in mind that RL is in the differential diagnosis of polycystic renal disease to prevent overtreatment. PMID: 33492306 [PubMed - in process] (Source: Iranian Journal of Kidney Diseases)
Source: Iranian Journal of Kidney Diseases - January 27, 2021 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

The Collapsing Variant of Focal Segmental Glomerulosclerosis (FSGS) Secondary to Sarcoidosis, A Very Rare Case.
Authors: Gok M, Ayten O, Onur O, Cetinkaya H, Gumrukcu G, Sahin G Abstract Sarcoidosis is a multisystemic granulomatous disease of unknown etiology. Renal involvement in sarcoidosis patients is occurred, but the incidence and prevalence is uncertain. The most common renal involvement of systemic sarcoidosis is nephrocalcinosis and interstitial nephritis. After sarcoidosis was diagnosed in a 31-year-old male patient, we performed a renal biopsy because of nephrotic range proteinuria and renal dysfunction. The collapsing variant of focal segmental glomerulosclerosis (FSGS) secondary to sarcoidosis was diagnosed by ki...
Source: Iranian Journal of Kidney Diseases - January 27, 2021 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Conceptual Approach to Body Fluids and Edema, Education Determines Clinical Outcomes in Nephrotic Syndrome Management.
The objective of our paper is to reemphasize the importance of critical thinking in clinical practice and education in the field of internal medicine using the example of edema. We provide an in-depth and interactive investigation of physiological concepts as a foundation for the understanding of body fluid dynamics. Four fundamental concepts described are the hydrostatic and oncotic pressure gradients, capillary permeability, and lymphatic drainage. Furthermore, we visit the causes of edema in nephrotic syndrome. Traditional teaching considers hypoalbuminemia as a primary cause of edema formation in nephrotic syndrome. It...
Source: Iranian Journal of Kidney Diseases - January 27, 2021 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Corona Virus Disease 2019 (COVID-19) and Its Effect on Renal System, A Systematic Review and Meta-analysis.
Authors: Vakhshoori M, Emami SA, Heidarpour M, Shafie D, Mortazavi M Abstract Coronavirus disease 2019 (COVID-19) has been recently emerged with various manifestations, mainly on respiratory system. However, other organs might also be involved. Acute kidney injury has been reported as a complication with high variability and controversial results. We aimed to define the frequency of AKI as well as two specific renal biomarkers including BUN and serum Cr among individuals suffering from COVID-19 infection. We investigated Medline/PubMed, Scopus, and Google Scholar databases until 16th April 2020 and included all rel...
Source: Iranian Journal of Kidney Diseases - December 7, 2020 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Incidence and Risk Factors of Post-renal Transplantation Malignancies in North of Iran, A 20-year Experience.
CONCLUSION: The most common malignancies in these people were non-melanoma skin cancer, Kaposi sarcoma and then GI malignancies. According to the information obtained in this study, regular periodic examinations of kidney transplant recipients for early detection of malignancy is important. PMID: 33277447 [PubMed - as supplied by publisher] (Source: Iranian Journal of Kidney Diseases)
Source: Iranian Journal of Kidney Diseases - December 7, 2020 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

The Relationship Between Renal Arterial Resistive Index (RRI) and Renal Outcomes in Patients with Resistant Hypertension.
CONCLUSION: These data demonstrate the clinical importance of renal Doppler that may be an effective way to evaluate the prognosis of renal involvement in resistant hypertension. PMID: 33277448 [PubMed - as supplied by publisher] (Source: Iranian Journal of Kidney Diseases)
Source: Iranian Journal of Kidney Diseases - December 7, 2020 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Association Between Serum IgG Concentrations and Prognosis in IgA Nephropathy.
Authors: Tang F, Hu H, Xu R, Tao C, Wan Q Abstract INTRODUCTION: To investigate the relationship between serum IgG (sIgG) concentration and the prognosis of IgA nephropathy (IgAN). METHODS: A total of 309 patients with biopsy-proven IgAN in the Second Referral Hospital of Shenzhen were enrolled between 2010/01 and 2017/06. Patients were divided into 3 groups on the basis of sIgG tertiles: 11.17 g/L (Group G3). RESULTS: As the level of sIgG increased, there was a decrease in DBP, serum creatinine, 24h urine proteinuria and an increase in serum albumin (all P
Source: Iranian Journal of Kidney Diseases - December 7, 2020 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Comparison Between eGFR by Schwartz Formula with Measured GFR by Radionuclide Diethylenetriamine Pentaacetic Acid Scan (Tc99 DTPA scan), in Patients Undergoing Chemotherapy with Nephrotoxic Drugs.
Authors: Esmaeilnejad SS, Nazari S, Esfandiar N Abstract INTRODUCTION: Children with malignancy who are under treatment with nephrotoxic drugs are at risk of renal dysfunction. Due to increased life expectancy, evaluation of drug toxicity is now of higher importance than before. The aim of this study is to compare two methods of GFR measurement. METHODS: An analytical study on children with malignancy undergoing chemotherapy with nephrotoxic drugs (cisplatin, carboplatin, cyclophosphamide, ifosfamind, etoposide) during 2016 and 2017 in Mofid Children Hospital was done. Demographic information, anthropometric me...
Source: Iranian Journal of Kidney Diseases - December 7, 2020 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Is There a Role for IgA/C3 Ratio in IgA Nephropathy Prognosis? An Outcome Analysis on An European Population.
CONCLUSION: Our study reports evidence that supports IgA/C3 ratio as a reasonable predictor of IgAN prognosis in European patients. PMID: 33277451 [PubMed - as supplied by publisher] (Source: Iranian Journal of Kidney Diseases)
Source: Iranian Journal of Kidney Diseases - December 7, 2020 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

The Effect of Oral Cyclophosphamide in the Treatment of Children with Refractory Idiopathic Nephrotic Syndrome.
CONCLUSION: It can be concluded that CP has no significant effect on the remission of SRNS patients, but has made a significant difference in the development of ESRD in patients. PMID: 33277452 [PubMed - as supplied by publisher] (Source: Iranian Journal of Kidney Diseases)
Source: Iranian Journal of Kidney Diseases - December 7, 2020 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Angiotensin Converting Enzyme Inhibitors, A Risk Factor of Poor Outcome in Diabetic Patients with COVID-19 Infection.
Authors: Aghaaliakbari F, Abbasi MA, Ranjbar M, Jamshidi Makiani M, Farrokhpour M, Safarnezhad Tameshkel F, Karbalaie Niya MH, Doltkhah S, Yaghoobzadeh K, Savaj S Abstract INTRODUCTION: Diabetes mellitus and hypertension are described as the most common comorbidities among COVID-19 patients. We investigated the adverse effect of ACEIs in diabetic and nondiabetic patients with COVID-19. METHODS: This prospective study consisted of 617 RT-PCR-confirmed COVID-19 inpatients. Demographic and baseline characteristics, underlying comorbid diseases, and antihypertensive drugs were evaluated. Study outcome (in-hospital ...
Source: Iranian Journal of Kidney Diseases - December 7, 2020 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

A Comparable Study on the Outcomes of Urgent Initiated Peritoneal Dialysis Versus Conventional Start, A Single Centre Study from North-East India.
CONCLUSION: Our study showed that catheter patency, technique survival, and catheter-related complications were comparable between UIPD and conventional start peritoneal dialysis. PMID: 33277454 [PubMed - as supplied by publisher] (Source: Iranian Journal of Kidney Diseases)
Source: Iranian Journal of Kidney Diseases - December 7, 2020 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Can L-Carnitine Supplementation Improve Cardiopulmonary Function? A Randomized Controlled Clinical Trial in Hemodialysis Patients.
Authors: Yassari F, Dastan F, Marashian SM, Eslaminejad A, Maleki Kazeri F Abstract INTRODUCTION: L-Carnitine is a cardioprotective agent which balances metabolism by promoting mitochondrial β-oxidation and facilitating transportation of long chain fatty acids into the mitochondrial matrix. It has been shown that L-Carnitine level in plasma and tissue is lower in hemodialysis patients and they may lose the benefits of this substance. The aim of this trial was to evaluate the effects of L-Carnitine supplementation on cardiorespiratory Function in hemodialysis patients through ergospirometry. METHODS: The cu...
Source: Iranian Journal of Kidney Diseases - December 7, 2020 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Association of Serum Fetuin-A with Vascular Calcification in Hemodialysis Patients and Its' Impact on 3-year Mortality.
Authors: Ossareh S, Rayatnia M, Vahedi M, Jafari H, Zebarjadi M Abstract INTRODUCTION: Atherosclerosis is associated with increased intima- media thickness (IMT) and vascular calcification (VC) in maintenance hemodialysis (MHD) patients. Fetuin-A is a serum protein, which inhibits vascular calcification. The aim of this study was to investigate the association between fetuin-A and VC, in a group of MHD patients. METHODS: One hundred and forty-three MHD patients were included and followed for 3 years. Blood samples were studied for calcification and inflammation markers and fetuin-A was checked 3 times at the st...
Source: Iranian Journal of Kidney Diseases - December 7, 2020 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Sirolimus Dose Requirement in Kidney Transplant Recipients in Iran.
This study has been done to show the target dose of Sirolimus in kidney transplanted patients in Isfahan. METHODS: This is a longitudinal cross-sectional study conducted from June 2018 to September 2019. The study population included all kidney transplanted patients treated with Sirolimus in a nephrology private clinic. Inclusion criteria were age (equal or more than 18 years old) and the existence of complete data in the patient's file. The participants were excluded if there were not at least two Sirolimus levels in the patient's file. Demographics and other variables were extracted from the patient's files. RESU...
Source: Iranian Journal of Kidney Diseases - December 7, 2020 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Amlodipine Induced Massive Ascites, a Rare Clinical Case.
CONCLUSION: We aimed to create awareness that pharmacologic causes should be considered in cases of ascites of unknown aetiology. PMID: 33277458 [PubMed - as supplied by publisher] (Source: Iranian Journal of Kidney Diseases)
Source: Iranian Journal of Kidney Diseases - December 7, 2020 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Impact of Circulating SARS-CoV-2 Mutant G614 on the COVID-19 Pandemic.
Authors: Ahmadpour D, Ahmadpoor P, Rostaing L Abstract Coronavirus family has caused several human illnesses, the latest caused by SARS-CoV-2, has led to COVID-19 pandemic posing serious threat to global health. A SARS-CoV-2 variant encoding a D614G mutation in the viral spike (S) protein has now become the most prevalent form of the virus worldwide, suggesting a fitness advantage for the mutant. The G614 variant is associated with higher upper respiratory tract viral load, higher infectivity, increased total S protein incorporation into the virion, reduced S1 shedding and a conformational change leading to a more ...
Source: Iranian Journal of Kidney Diseases - September 20, 2020 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Biomarkers in Primary Membranous Nephropathy, A Guide to Precision Medicine.
Authors: Nafar M, Dalili N, Samavat S Abstract Membranous nephropathy (MN) as one of the most common glomerulonephritis still relies on an invasive procedure of kidney biopsy for precise recognition. Over the recent past years noninvasive methods using wide range of biomarkers have been developed in order to diagnose and estimating the final prognosis of MN. Plasma, urine and tissue are readily accessible specimens for identification of these biomarkers. In order to utilize a single biomarker or a panel of them for detection of a specific entity, many factors should taking into consideration like the accuracy, prec...
Source: Iranian Journal of Kidney Diseases - September 20, 2020 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

The Effect of Parental Consanguinity on Clinical Course and Outcome of Children with Focal Segmental Glomerulosclerosis, a Report from Isfahan, Iran.
Authors: Gheissari A, Meamar R, Kheirollahi M, Abedini A Abstract INTRODUCTION: Focal segmental glomerulosclerosis (FSGS) accounts for 20% of nephrotic syndromes among children as well as 75% of the steroid resistant nephrotic syndrome (SRNS). The aim of the present study was to evaluate the influence of parental consanguinity on clinical course and outcome of FSGS in children. METHODS: This historical cohort was carried out on 69 children affected by steroid resistant FSGS. Patients' data were recorded at the initial and the final analyses and response to therapeutic measures. Subjects were also questioned abo...
Source: Iranian Journal of Kidney Diseases - September 20, 2020 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

The Survey of Relationship Between Resistance Index of Renal Artery and Albuminuria in Diabetic Patients Referring to Shahid Sayyad Shirazi Hospital, 2017 to 2018.
CONCLUSION: In the current study, the patient's albuminuria, type of treatment and HbA1c had no effect on the RI. The study also found that an increase in the RI index could be a significant predictor of renal dysfunction and increased creatinine. PMID: 32943590 [PubMed - in process] (Source: Iranian Journal of Kidney Diseases)
Source: Iranian Journal of Kidney Diseases - September 20, 2020 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Comparison Between RIFLE, AKIN, and KDIGO: Acute Kidney Injury Definition Criteria for Prediction of In-hospital Mortality in Critically Ill Patients.
This study was conducted to determine the incidence of AKI in the medical intensive care unit of a tertiary university hospital and to compare the predictive performance of three different AKI criteria (RIFLE, AKIN, and KDIGO) for in-hospital mortality. METHODS: The data of all consecutive patients were evaluated from their hospitalization to ICU until discharge or death, retrospectively. Patients with end-stage renal disease, history of kidney transplantation, those who stayed in the ICU for less than 72 hours, who underwent dialysis before admission to the ICU, and those with incomplete medical records were excluded....
Source: Iranian Journal of Kidney Diseases - September 20, 2020 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Evaluation of Urinary Neutrophil Gelatinase-associated Lipocalin as a Biomarker in Pediatric Vesicoureteral Reflux Assessment.
This study aimed to investigate the predictive value of urinary neutrophil gelatinase-associated lipocalin (uNGAL) as a non-invasive biomarker of reflux nephropathy in pediatric with primary VUR. METHODS: This case-control study was performed on 63 children with primary VUR and 72 age- and sex-matched healthy children as controls. Urinary NGAL and creatinine levels were measured and compared between patients and control groups as well as among the subgroups of patients in terms of disease severity. RESULTS: Among patients, 9 cases were diagnosed as mild, 35 as moderate, and 19 with a severe form of VUR. We observed...
Source: Iranian Journal of Kidney Diseases - September 20, 2020 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Relationship Between Thyroid Hormones and Left Ventricular Mass in Peritoneal Dialysis Patients.
This study is designed to investigate the relationship between left ventricular mass and thyroid hormone abnormalities and evaluate this relationship after adjustment of inflammatory factors and nutritional status in peritoneal dialysis patients. METHODS: A total of 71 patients undergoing maintenance peritoneal dialysis were included. Serum concentration of total and free triiodothyronine (fT3), total and free thyroxine (fT4), and TSH were measured. LV mass index and the structural properties of heart including LVEDD, LVESD, PWD, and EF were assessed by transthoracic echocardiography. The Surrogates of Inflammation, in...
Source: Iranian Journal of Kidney Diseases - September 20, 2020 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Role of Screening for COVID-19 in Hemodialysis Wards, Results of a Single Center Study.
Authors: Ossareh S, Bagheri M, Abbasi M, Abolfathi S, Bohlooli A Abstract INTRODUCTION: Seven months after the emergence of SARS-COV-2 virus, there is paucity of data regarding the epidemiology of the virus in hemodialysis patients. We aim to present the results of the screening program implied after outbreak of COVID-19 in a referral hemodialysis ward. METHODS: We started clinical screening and obligatory mask wearing for dialysis patients and personnel on 20-Feb-2020. However 11 symptomatic COVID-19 patients emerged till day +36. On days +39 and +40 a screening program was implied including measurement of SAR...
Source: Iranian Journal of Kidney Diseases - September 20, 2020 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Relationship Between Pulmonary Hypertension Before Kidney Transplantation and Early Graft Dysfunction.
Authors: Abasi K, Lotfi Z, Ahmadi M, Majd HM, Hasanzamani B Abstract INTRODUCTION: Pulmonary hypertension (PHTN) is a common complication in patients with chronic kidney disease. Delayed Graft Function (DGF), on the other hand; is an essential complication after kidney transplantation. These two complications increase morbidity and mortality in patients. The effect of PHTN on cardiovascular and graft blood supply, as well as the same mechanisms underlying PTHN and DGF; led us to investigate the relationship between them. METHODS: In this retrospective cohort study, 306 patients aged 18 years or older who underw...
Source: Iranian Journal of Kidney Diseases - September 20, 2020 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Bone Mineral Density and Related Factors in Renal Transplant Recipients, in the North of Iran.
In this study, 73 patients (49.3%) had osteopenia and 28 patients (18.9%) were osteoporotic. BMI was significantly lower in the osteoporosis group compared with the normal group (P
Source: Iranian Journal of Kidney Diseases - September 20, 2020 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Resolution of Eosinophilic Peritonitis with Hypoalbuminemia by Oral Prednisone Acetate in an Elderly Patient Receiving Continuous Ambulatory Peritoneal Dialysis.
Authors: Yang B, Li J, Qiao Y, Zhao Y, Yang H Abstract A 79-year-old patient developed severe hypoalbuminemia associated with eosinophilic peritonitis (EP) after receiving continuous ambulatory peritoneal dialysis (CAPD) for 3 years. The hypoalbuminemia and EP treated successfully with the use of prednisone acetate. This case is reported to emphasize the importance of diagnosis of EP that should be suspected when the peritoneal dialysis (PD) patient presents with severe hypoalbuminemia combined with turbid effluent along with repeated negative cultures. A short course of low-dose oral glucocorticoid may be consider...
Source: Iranian Journal of Kidney Diseases - September 20, 2020 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Bullous Pemphigoid in a Renal Transplant Recipient, A Case Report and Review of the Literature.
We present a case of BP in a 33-year-old man with history of bladder exstrophy from birth and renal transplantation from 5 years ago. There was no finding in favour of his disease was caused by graft rejection, drug usage, or viral infection. Therefore, BP could be an accidental finding in this patient with idiopathic aetiology. PMID: 32943598 [PubMed - in process] (Source: Iranian Journal of Kidney Diseases)
Source: Iranian Journal of Kidney Diseases - September 20, 2020 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Fluid Balance in Patients After Cardiac Surgery.
Authors: Xu Q, Jiang J Abstract No Abstract. PMID: 32943599 [PubMed - in process] (Source: Iranian Journal of Kidney Diseases)
Source: Iranian Journal of Kidney Diseases - September 20, 2020 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Pharmacotherapy Considerations in CKD Patients With COVID-19, A Narrative Review.
Authors: Dashti-Khavidaki S, Khalili H, Nourian A Abstract Treatment of coronavirus disease 2019 (COVID-19) among patients with CKD requires special pharmacotherapy considerations that are reviewed here. Literature review was done for several pharmacotherapy aspects in CKD patients including selection and modification of COVID-19 treatment, drug interactions, nephrotoxicity of drugs that are used for treatment of COVID-19 and potential risks/benefits of routine medications of CKD patients during COVID-19 pandemic. CKD patients should be treated according to local or national COVID-19 protocols as other patients. Bu...
Source: Iranian Journal of Kidney Diseases - July 14, 2020 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Effects of Carvedilol on Cardiovascular Events and Mortality in Hemodialysis Patients, A Systematic Review and Meta-Analysis.
Authors: Tan Z, Ke G, Huang J, Yang D, Pi M, Li L, Liu X, Tao S, Chen L, Liang G, Liu S Abstract Carvedilol, the third generation of vasodilators; serves as the blocker of non-selective beta-adrenergic receptor and alpha1 adrenergic receptor. It could protect the cardiovascular system of patients receiving dialysis treatment. However, current clinical trials discussing the therapeutic benefit of carvedilol on patients receiving dialysis treatment remain inconsistent. Consequently, we decided to perform a meta-analysis to evaluate the clinical efficacy of carvedilol on patients receiving dialysis treatment. A search...
Source: Iranian Journal of Kidney Diseases - July 14, 2020 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Clinical and Radiologic Characteristics of COVID-19 in Patients With CKD.
In this study, we aimed to evaluate the presentation and outcome of COVID-19 in patients with chronic kidney disease (CKD). METHODS: We included 43 patients with a past history of CKD and confirmed diagnosis of COVID-19. Patients were evaluated for demographic characteristics, clinical and laboratory data and findings of initial chest computed tomography (CT) and were followed until either death or discharge occurred. Then, study variables were compared based on final outcome and stage of CKD. RESULTS: Mean age ± SD of patients was 60.65 ± 14.36 years; 65.1% were male. Five of 43 patients (11.6%) died...
Source: Iranian Journal of Kidney Diseases - July 14, 2020 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Urinary System and Renal Involvement in Children With Cystic Fibrosis.
CONCLUSION: Crystalluria is a common consequence of cystic fibrosis in childhood. The prevailing crystalluric finding includes hypercalciuria followed by hyperuricosuria, and hyperoxaluria. During disease GFR may be decreased due to several reasons such as nephrotoxic drugs usage. PMID: 32655022 [PubMed - in process] (Source: Iranian Journal of Kidney Diseases)
Source: Iranian Journal of Kidney Diseases - July 14, 2020 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

High Neutrophil/Lymphocyte Ratio as an Independent Risk Factor for the First Occurrence of Stroke in Peritoneal Dialysis Patients.
This study aims to investigate the association between NLR and the first occurrence of stroke in PD patients. METHODS: In this retrospective cohort study, 1507 PD patients were enrolled from four centers in China and stratified into tertiles of NLR levels. The incidence of the first occurrence of stroke was analyzed by Kaplan-Meier cumulative incidence curve among different NLR tertiles, competing risk analysis was used to calculate the incidence of the first occurrence of stroke in the presence of competing risk of other events, multivariable COX regression analysis was performed to estimate the hazard ratios (HRs) fo...
Source: Iranian Journal of Kidney Diseases - July 14, 2020 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

The Effects of Nano-curcumin on Metabolic Status in Patients With Diabetes on Hemodialysis, a Randomized, Double Blind, Placebo-controlled Trial.
This study evaluated the effects of nano-curcumin intake on metabolic status in patients with diabetes on hemodialysis (HD). METHODS: This randomized, double-blind, placebo-controlled clinical trial was performed on 60 patients with diabetes on HD. Participants were randomly divided into two groups to take either 80 mg/d nano-curcumin (n = 30) or placebo (n = 30) for 12 weeks. RESULTS: Nano-curcumin significantly decreased fasting plasma glucose (β = -19.68 mg/dL, 95% CI: -33.48 to -5.88; P
Source: Iranian Journal of Kidney Diseases - July 14, 2020 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

The Added Value of Trabecular Bone Score in Fracture Risk Assessment of Kidney Transplant Recipients.
Authors: Malakoutian T, Mirzaei A, Shiroudbakhshi A, Amini Kadijani A, Tehrani-Banihashemi A, Zabihiyeganeh M Abstract INTRODUCTION: Trabecular Bone Score (TBS) is an index of bone microarchitecture independent of Bone Mineral Density (BMD). Recently, TBS data has been used to optimize the predictive value of the Fracture Risk Assessment Tool (FRAX). The aim of this study was to evaluate the clinical value of FRAX adjustment with TBS in kidney transplant recipients. METHODS: Seventy post-transplant Iranian kidney recipients were included in this study. After the evaluation of BMD and TBS, the risk of major oste...
Source: Iranian Journal of Kidney Diseases - July 14, 2020 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

The Prevalence of Renal Scars Among Infants Under One Year Old With a First UTI With or Without VUR in Qom, Iran, 2017.
Authors: Akhavan Sepahi M, Toloii F, Arsang Jang S, Hoseini BL Abstract Renal scarring with reflux develops renal nephropathy. The risk is higher when it is associated with urinary tract infection (UTI). Hence, we investigated the prevalence of renal scars among children under one-year-old with the first UTI in Qom, Iran. We conducted this retrospective study on 140 infants divided in two reflux (n = 70) and non-reflux (n = 70) groups. Participant's records had been analyzed by descriptive and analytic statistics. The prevalence of renal scar was 32.12% among all 140 infants. The prevalence of renal scars among chi...
Source: Iranian Journal of Kidney Diseases - July 14, 2020 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Proteinuria in Two Sisters with Beaulieu-Boycott-Innes Syndrome, A Case Report.
We report two sisters (13- and 4-year-old) presenting with moderate intellectual disability, dysmorphic facial features, intermittent hematuria, proteinuria, and dental caries. Their parents and other family members were not affected. Whole-exome sequencing was performed to screen the underlying genetic cause. These patients have been analyzed using Next-Generation Sequencing (NGS) method and homozygote variant (c.890delC) has been detected in the THOC6 gene. Direct Sanger sequencing confirmed that they are homozygote for the pathogenic variant mutations in the THOC6 gene, which is associated with Beaulieu-Boycott-Innes sy...
Source: Iranian Journal of Kidney Diseases - July 14, 2020 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Peritoneal Dialysis in Extremely Obese Patient From Palestine, A Case Report.
CONCLUSION: Obesity should not impede the beneficial effects of PD. The obstacles of obesity, which we faced; could be overcome with the collaboration between a highly qualified multidisciplinary team. PMID: 32655028 [PubMed - in process] (Source: Iranian Journal of Kidney Diseases)
Source: Iranian Journal of Kidney Diseases - July 14, 2020 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Late Acute Cellular Rejection After Anakinra Treatment in a Kidney Transplant Patient, Is It a Coincidence?
Authors: Yeter HH, Yetkin N, Akcay O, Derici U, Arinsoy T Abstract Familial mediterranean fever (FMF) is an autosomal recessive auto-inflammatory disorder, which could lead to secondary (AA) amyloidosis. Anakinra is an IL-1 receptor blocker and a treatment option for patients with FMF. There is no reported rejection episode associated with the use of Anakinra in the literature. A fortynine years old woman with a history of kidney transplantation is described here. Anakinra was initiated in the patients whose FMF attacks were exacerbated, and the inflammation could not be controlled under the colchicine treatment. A...
Source: Iranian Journal of Kidney Diseases - July 14, 2020 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Surveillance and Isolation Based Strategies to Prevent COVID-19 in a Dialysis Center of Tehran, a Customized Approach.
Authors: Najafi MT, Abbasi MR, Dehghan Manshadi SA, Rahimzadeh S, Shojamoradi MH PMID: 32655030 [PubMed - in process] (Source: Iranian Journal of Kidney Diseases)
Source: Iranian Journal of Kidney Diseases - July 14, 2020 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Comment: Newly Diagnosed Glomerulonephritis During COVID-19 Infection Undergoing Immunosuppression Therapy, a Case Report.
Authors: Mubarak M, Tolouian R, Kowalewska J, Nasri H PMID: 32655031 [PubMed - in process] (Source: Iranian Journal of Kidney Diseases)
Source: Iranian Journal of Kidney Diseases - July 14, 2020 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research