Aortic thrombosis and acute kidney injury due to atherosclerosis in a dog
J Am Vet Med Assoc. 2024 Apr 26:1-4. doi: 10.2460/javma.24.03.0154. Online ahead of print.ABSTRACTOBJECTIVE: Atherosclerosis is a chronic lipid-driven inflammatory disease of the arterial wall. Due to its cardiovascular ischemic complications, it is one of the most common causes of death in people. However, atherosclerosis is seldomly reported in dogs.ANIMAL: A 10-year-old male mixed-breed dog.CLINICAL PRESENTATION, PROGRESSION, AND PROCEDURES: Severe acute kidney injury associated with thrombosis of the abdominal aorta.TREATMENT AND OUTCOME: Treatment included renal replacement therapy, antithrombotic therapy, and support...
Source: Atherosclerosis - April 26, 2024 Category: Cardiology Authors: Andrea Gonz ález-Domínguez Jorge Rosell Tormo Vicente J Herrer ía-Bustillo Source Type: research
Association of the trimethylamine N-oxide with cardiovascular risk and vascular alterations in middle-aged patients with risk factors for cardiovascular diseases
Conclusions: TMAO levels are increased with expanded CVD risk. Across different types of vascular damage, TMAO is associated with atherosclerotic changes.PMID:38669041 | DOI:10.1042/BSR20232090 (Source: Atherosclerosis)
Source: Atherosclerosis - April 26, 2024 Category: Cardiology Authors: Natalia Spasova Desislava Somleva Bozhidar Krastev Radostina Ilieva Angelina Borizanova Dobrin Svinarov Elena Kinova Assen Goudev Source Type: research
Non-Invasive Assessment of Micro- and Macrovascular Function after Initiation of JAK Inhibitors in Patients with Rheumatoid Arthritis
CONCLUSIONS: Three-month treatment with JAK inhibitors may exert significant effects on microcirculation as assessed with nailfold videocapillaroscopy, whereas macrovascular structure and function appears largely unaffected. Further research toward this direction may add substantial information to the available literature regarding cardiovascular aspects of JAK inhibitors in RA.PMID:38667479 | PMC:PMC11048865 | DOI:10.3390/diagnostics14080834 (Source: Atherosclerosis)
Source: Atherosclerosis - April 26, 2024 Category: Cardiology Authors: Panagiota Anyfanti Elena Angeloudi Athanasia Dara Eleni Pagkopoulou Georgia-Savina Moysidou Kleopatra Deuteraiou Maria Boutel Eleni Bekiari Michael Doumas George D Kitas Theodoros Dimitroulas Source Type: research
Longitudinal associations of the alternative healthy eating index with coronary artery calcification and pericardial adiposity in US adults with and without type 1 diabetes
CONCLUSION: The AHEI score is inversely associated with PAT; the association revealed greater magnitude of PAT reduction in the non-DM group. The AHEI score did not associate with CAC progression.PMID:38670920 | DOI:10.1016/j.numecd.2024.03.019 (Source: Atherosclerosis)
Source: Atherosclerosis - April 26, 2024 Category: Cardiology Authors: Leigh Ann Richardson Arpita Basu Lung-Chang Chien Tiantian Pang Amy C Alman Janet K Snell-Bergeon Source Type: research
Atherosclerosis Residual Lipid Risk-Overview of Existing and Future Pharmacotherapies
J Cardiovasc Dev Dis. 2024 Apr 21;11(4):126. doi: 10.3390/jcdd11040126.ABSTRACTPatients with atherosclerotic disease remain at increased risk of future events despite receiving optimal medical treatment. This residual risk is widely heterogeneous, but lipoprotein particles and their content play a major role in determining future cardiovascular events. Beyond low-density lipoprotein cholesterol (LDL-c), other lipoprotein particles have not demonstrated similar contribution to the progression of atherosclerosis. Statins, ezetimibe, and more recently, proprotein convertase subtilisin kexin 9 (PCSK9) inhibitors and bempedoic ...
Source: Atherosclerosis - April 26, 2024 Category: Cardiology Authors: Muntaser Omari Mohammad Alkhalil Source Type: research
Simplified Criteria for Identification of Familial Hypercholesterolemia in Children: Application in Real Life
CONCLUSIONS: In the pediatric population, the combination of LDL-C ≥95th percentile in the proband and the dominant inheritance pattern of hypercholesterolemia, with LDL-C ≥95th percentile in one parent, is a simple, useful and effective diagnostic criterion, showing high MDR. This pattern is crucial for early FH diagnosis. EAS, SBR and LIPIGEN-FH-PED criteria can underestimate the real number of patients with gene mutations and cannot be considered strictly discriminant for the execution of molecular analysis.PMID:38667741 | PMC:PMC11050898 | DOI:10.3390/jcdd11040123 (Source: Atherosclerosis)
Source: Atherosclerosis - April 26, 2024 Category: Cardiology Authors: Raffaele Buganza Giulia Massini Maria Donata Di Taranto Giovanna Cardiero Luisa de Sanctis Ornella Guardamagna Source Type: research
Inflammatory Cells in Adipose Tissue and Skeletal Muscle of Patients with Peripheral Arterial Disease or Chronic Venous Disease: A Prospective, Observational, and Histological Study
J Cardiovasc Dev Dis. 2024 Apr 16;11(4):121. doi: 10.3390/jcdd11040121.ABSTRACTThe main goal of this study was to assess whether the presence of peripheral arterial disease (PAD) correlates with increased inflammatory cell infiltration. An observational, single-centre, and prospective study was conducted from January 2018 to July 2022. Clinical characteristics and anthropometric measures were registered. Consecutive PAD patients with surgical indications for a common femoral artery approach and patients with varicose veins with an indication for surgical ligation of the saphenofemoral junction were included. In both groups...
Source: Atherosclerosis - April 26, 2024 Category: Cardiology Authors: Joana Ferreira Adhemar Longatto-Filho Julieta Afonso Susana Roque Alexandre Lima Carneiro Isabel Vila Cristina Silva Cristina Cunha Am ílcar Mesquita Jorge Cotter Margarida Correia-Neves Armando Mansilha Pedro Cunha Source Type: research
Contemporary management of obesity: A comparison of bariatric metabolic surgery and novel incretin mimetic drugs
Diabetes Technol Ther. 2024 Apr 26. doi: 10.1089/dia.2024.0122. Online ahead of print.ABSTRACTThe global prevalence of obesity has risen sharply during the past half-century, reaching pandemic proportions and creating a public health crisis. Obesity is a recognized risk factor for the development of diabetes, atherosclerosis, hypertension, hepatic steatosis, and many other cardiometabolic disorders with significant resultant morbidity and mortality. Though treatment of obesity can prevent or slow the progression of these aforementioned illnesses, efforts to help patients achieve reliable and sustainable weight loss have ha...
Source: Atherosclerosis - April 26, 2024 Category: Cardiology Authors: Abhayjit Singh Steven E Nissen Source Type: research
Lactylation Modification in Cardiometabolic Disorders: Function and Mechanism
This article discusses the molecular biology of lactylation modifications and outlines the roles and mechanisms of lactylation modifications in cardiometabolic disorders, offering valuable insights for the diagnosis and treatment of such conditions.PMID:38668345 | PMC:PMC11052226 | DOI:10.3390/metabo14040217 (Source: Atherosclerosis)
Source: Atherosclerosis - April 26, 2024 Category: Cardiology Authors: Xu Li Pingdong Cai Xinyuan Tang Yingzi Wu Yue Zhang Xianglu Rong Source Type: research
The Interplay of Microbiome Dysbiosis and Cardiovascular Disease
Cardiol Rev. 2024 Apr 26. doi: 10.1097/CRD.0000000000000701. Online ahead of print.ABSTRACTThe intricate ecosystem of the mammalian gut, which hosts a diverse microbiome, plays a vital role in various physiological functions. Trillions of bacteria within the gut contribute to host metabolism, immune modulation, energy homeostasis, and more. Emerging research highlights the gut microbiota's significant impact on cardiovascular diseases (CVDs), with intestinal dysbiosis identified as a risk factor for conditions such as obesity and diabetes, both linked to atherosclerosis. Chronic inflammation, pivotal in atherosclerosis, is...
Source: Atherosclerosis - April 26, 2024 Category: Cardiology Authors: Anas Zaher Jude Elsaygh Stephen J Peterson Ilan S Weisberg Manish A Parikh William H Frishman Source Type: research
The relationship between atherosclerosis and dementia
CONCLUSION: Cognitively impaired individuals, in particular those with vascular cognitive impairment, have poorer quality of life and shorter survival. Risk factors contributing to such impairment are similar to those for ischaemic or haemorrhagic stroke. It may be concluded that most of the analysed risk factors play a role in the development of both atherosclerosis and dementia.PMID:38669152 | DOI:10.21101/cejph.a7848 (Source: Atherosclerosis)
Source: Atherosclerosis - April 26, 2024 Category: Cardiology Authors: Jana Janoutov á Ond řej Machaczka Martina Kovalov á Anna Zatloukalov á Petr Ambroz Veronika Koutn á Eva Mr ázková Michal Bar Martin Roubec Petra B ártová Richard Novobilsk ý Martin Sabela Pavl ína Kušnierová David Stejskal Lucie Faldynov á S Source Type: research
Cardiovascular Risk Associated With Social Determinants of Health at Individual and Area Levels
CONCLUSIONS AND RELEVANCE: In this cohort study, both individual- and area-level SDOH were associated with ASCVD risk; adding both individual- and area-level SDOH to the PCEs modestly improved discrimination and calibration for estimating ASCVD risk for Black individuals, and adding individual-level SDOH to PREVENT plus SDI also modestly improved calibration. These findings suggest that both individual- and area-level SDOH may be considered in future development of ASCVD risk assessment tools, particularly among Black individuals.PMID:38669015 | DOI:10.1001/jamanetworkopen.2024.8584 (Source: Atherosclerosis)
Source: Atherosclerosis - April 26, 2024 Category: Cardiology Authors: Mengying Xia Jaejin An Monika M Safford Lisandro D Colantonio Mario Sims Kristi Reynolds Andrew E Moran Yiyi Zhang Source Type: research
Unravelling the role of cathepsins in cardiovascular diseases
Mol Biol Rep. 2024 Apr 26;51(1):579. doi: 10.1007/s11033-024-09518-1.ABSTRACTLysosomal cathepsins as a regulatory medium have been assessed as potential therapeutic targets for the treatment of various cardiac diseases such as abdominal aortic aneurysm, hypertension, cardiomyopathy, coronary heart disease, atherosclerosis, etc. They are ubiquitous lysosomal proteases with papain-like folded protein structures that are involved in a variety of physiological processes, such as the digestion of proteins, activation of pro-inflammatory molecules, degradation of extracellular matrix components, and maturation of peptide hormone...
Source: Atherosclerosis - April 26, 2024 Category: Cardiology Authors: Sonali Maheshwari Bhoomika M Patel Source Type: research
A Novel Artificial Coronary Plaque to Model Coronary Heart Disease
CONCLUSION: This artificial atherosclerotic plaque model works as a simulating tool for future medical testing and could be crucial for further specified research on coronary artery disease and is going to help to provide information about the optimal interventional and surgical care of the disease.PMID:38667208 | PMC:PMC11048636 | DOI:10.3390/biomimetics9040197 (Source: Atherosclerosis)
Source: Atherosclerosis - April 26, 2024 Category: Cardiology Authors: Philipp Lindenhahn Jannik Richter Iliyana Pepelanova Bettina Seeger Holger A Volk Rabea Hinkel Bernhard Hiebl Thomas Scheper Jan B Hinrichs Lena S Becker Axel Haverich Tim Kaufeld Source Type: research
Aortic valve replacement for aortic stenosis: Influence of centre volume on TAVR adoption rates and outcomes in France
CONCLUSIONS: In a centralized public healthcare system, the total number of AVRs increased linearly between 2007 and 2019, mostly due to an increase in TAVR, irrespective of centre volume. Progressive declines in patient risk profiles and death rates were observed in all terciles; in 2017-2019 death rates were similar in all terciles, although lower in high-volume centres for SAVR.PMID:38670869 | DOI:10.1016/j.acvd.2024.02.007 (Source: Archives of Cardiovascular Diseases)
Source: Archives of Cardiovascular Diseases - April 26, 2024 Category: Cardiology Authors: Nadav Willner Virginia Nguyen Graeme Prosperi-Porta Helene Eltchaninoff Ian G Burwash Morgane Michel Eric Durand Martine Gilard Christel Dindorf Julien Dreyfus Bernard Iung Alain Cribier Alec Vahanian Karine Chevreul David Messika-Zeitoun Source Type: research
