Treat-to-target or treat-to-dissolve strategy to improve gout treatment
Nature Reviews Rheumatology, Published online: 26 April 2024; doi:10.1038/s41584-024-01117-5Medication adherence in gout is low, and discontinuation of urate-lowering therapy puts patients at risk of flares and cardiovascular events. A strategy to regularly monitor serum urate levels and the dissolution of urate deposits (particularly if visualized by patients) might encourage adherence in the long term. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - April 26, 2024 Category: Rheumatology Authors: Pascal Richette Nicola Dalbeth Source Type: research
Applications of SGLT2 inhibitors beyond glycaemic control
Nature Reviews Nephrology, Published online: 26 April 2024; doi:10.1038/s41581-024-00836-yHere, the authors discuss the beneficial effects of sodium–glucose cotransporter 2 (SGLT2) inhibitors for a range of clinical outcomes beyond glucose lowering, including kidney and cardiovascular protection. They also discuss the need for implementation and adherence initiatives to help translate the benefits of these agents into real-world clinical outcomes. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 26, 2024 Category: Urology & Nephrology Authors: Daniel V. O ’Hara Carolyn S. P. Lam John J. V. McMurray Tae Won Yi Samantha Hocking Jessica Dawson Smriti Raichand Andrzej S. Januszewski Meg J. Jardine Source Type: research
Molecules, Vol. 29, Pages 2005: Potential Targets of Natural Products for Improving Cardiac Ischemic Injury: The Role of Nrf2 Signaling Transduction
Zhang
Myocardial ischemia is the leading cause of health loss from cardiovascular disease worldwide. Myocardial ischemia and hypoxia during exercise trigger the risk of sudden exercise death which, in severe cases, will further lead to myocardial infarction. The Nrf2 transcription factor is an important antioxidant regulator that is extensively engaged in biological processes such as oxidative stress, inflammatory response, apoptosis, and mitochondrial malfunction. It has a significant role in the prevention and treatment of several cardiovascular illnesses, since it can control not only the expression of several an...
Source: Molecules - April 26, 2024 Category: Chemistry Authors: Wang Han Dmitrii Zhang Tags: Review Source Type: research
Molecules, Vol. 29, Pages 2007: Pharmacological Potential of Kaempferol, a Flavonoid in the Management of Pathogenesis via Modulation of Inflammation and Other Biological Activities
udi
Rahmani
Natural products and their bioactive compounds have been used for centuries to prevent and treat numerous diseases. Kaempferol, a flavonoid found in vegetables, fruits, and spices, is recognized for its various beneficial properties, including its antioxidant and anti-inflammatory potential. This molecule has been identified as a potential means of managing different pathogenesis due to its capability to manage various biological activities. Moreover, this compound has a wide range of health-promoting benefits, such as cardioprotective, neuroprotective, hepatoprotective, and anti-diabetic, and has a role...
Source: Molecules - April 26, 2024 Category: Chemistry Authors: Alrumaihi Almatroodi Alharbi Alwanian Alharbi Almatroudi Rahmani Tags: Review Source Type: research
IJERPH, Vol. 21, Pages 549: Wrist Circumference Cutoff Points for Determining Excess Weight Levels and Predicting Cardiometabolic Risk in Adults
Conclusions: Wrist circumference showed a significant correlation with other adiposity indicators and can be used to identify adults with excess weight and predict cardiometabolic risk. (Source: International Journal of Environmental Research and Public Health)
Source: International Journal of Environmental Research and Public Health - April 26, 2024 Category: Environmental Health Authors: Larissa Monteiro Costa Pereira M árcia Ferreira Cândido de Souza Felipe J. Aidar M árcio Getirana-Mota Alex Menezes dos Santos-Junior Mario Francisco Dantas de Santana Filho Marcos Antonio Almeida-Santos Raysa Manuelle Santos Rocha Rebeca Rocha de Alme Tags: Article Source Type: research
Effect of acute high-intensity interval exercise on a mouse model of doxorubicin-induced cardiotoxicity: a pilot study
ConclusionsIn this pilot murine study, one single HIIE session did not exacerbate acute doxorubicin-induced cardiotoxicity. The timing of the HIIE session following DOX injection and the level of compliance to exercise could influence the negative impact of DOX on cardiac function. (Source: BMC Sports Science, Medicine and Rehabilitation)
Source: BMC Sports Science, Medicine and Rehabilitation - April 26, 2024 Category: Sports Medicine Source Type: research
Response to: The Synergism of Public Health Policies and Social Work May Reduce Mortality from Cancer, Liver Disease and Cardiovascular Disease
We appreciate the interest that emerged from our recent publication [1], ‘Association between public health policies on alcohol and worldwide cancer, liver disease, and cardiovascular disease outcomes’ [2]. In our research, we evidenced a strong relationship between alcohol-related public health policies (PHP) establishment and the decrease of alcohol-related health consequences over time among 169 countries, including liver disease and other significant causes of burden of disease worldwide. These associations were stronger over time, and consistent with the framework SAFER proposed by the World Health Organization (W...
Source: Journal of Hepatology - April 26, 2024 Category: Gastroenterology Authors: Luis Antonio D íaz, Eduardo Fuentes-López, Juan Pablo Arab Tags: Letter to the Editor Source Type: research
Guanfacine poisoning resulting in transient ST-segment elevation: a case report
ConclusionsThis case highlights the need for careful monitoring of guanfacine poisoning patients due to the potential for various cardiovascular events. (Source: International Journal of Emergency Medicine)
Source: International Journal of Emergency Medicine - April 26, 2024 Category: Emergency Medicine Source Type: research
Cardiovascular Health and Disease in the Pakistani American Population
AbstractPurpose of ReviewThis narrative review seeks to elucidate clinical and social factors influencing cardiovascular health, explore the challenges and potential solutions for enhancing cardiovascular health, and identify areas where further research is needed to better understand cardiovascular issues in native and American Pakistani populations.Recent FindingsThe prevalence of cardiometabolic disease is high not only in Pakistan but also among its global diaspora. This situation is further complicated by the inadequacy of current cardiovascular risk assessment tools, which often fall short of accurately gauging the r...
Source: Current Atherosclerosis Reports - April 26, 2024 Category: Cardiology Source Type: research
Long-Term Efficacy and Safety of Once-Weekly Semaglutide for Weight Loss in Patients Without Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Semaglutide, a glucagon-like peptide-1 receptor agonist, has demonstrated clinically important weight loss effects in patients with type 2 diabetes. However, its effects on sustained weight loss among individuals without diabetes remains unclear. Our objective was to examine the long-term efficacy and safety of semaglutide use for weight loss among individuals with overweight/obesity and without diabetes. MEDLINE, Embase, and the Cochrane Libraries were systematically searched to identify randomized controlled trials (RCTs) that randomized participants with overweight/obesity but without diabetes to once-weekly 2.4 mg subc...
Source: The American Journal of Cardiology - April 26, 2024 Category: Cardiology Authors: Areesha Moiz, Jeremy Y. Levett, Kristian B. Filion, Katya Peri, Pauline Reynier, Mark J. Eisenberg Source Type: research
Trends in percutaneous left atrial appendage occlusion and 1-year mortality 2013 –2021: A nationwide observational study
Percutaneous left atrial appendage occlusion (LAAO) is increasingly used for stroke prevention in patients with atrial fibrillation and anticoagulant-related complications. Yet, real-life studies evaluating changes in patient characteristics and indications for LAAO remain scarce. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 26, 2024 Category: Cardiology Authors: Olivia J. Madsen, Morten Lamberts, Jonas B. Olesen, Morten L. Hansen, Thomas K ümler, Erik L. Grove, Niels H. Andersen, Emil Fosbøl, Ole De Backer, Jarl E. Strange Source Type: research
The SR-B1 ΔCT/LDLR KO mouse: A new tool to shed light on coronary artery disease.
Coronary artery disease (CAD) is known to be one of the leading causes of death in humans [1]. It occurs when atherosclerotic lesions gradually build up in the coronary arteries, leading to a narrowing or obstruction of these arteries, the function of which is to supply oxygenated blood and nutrients to the heart [2]. CAD can result in a range of clinical presentations, with mild symptoms such as chest pain or shortness of breath, to life-threatening conditions, namely myocardial infarction [2]. (Source: Atherosclerosis)
Source: Atherosclerosis - April 26, 2024 Category: Cardiology Authors: Bartolo Ferraro Source Type: research
My Journey as a Heart Transplantation Patient …and What I Want Providers to Know: Part II
JCF is honored to share this Patient Experience Series over the next 3 weeks. If you have not yet read the first part of this series, you can do so here (https://doi.org/10.1016/j.cardfail.2024.04.005). Part II of the series is below. The full story will be published in the May 2024 issue and online under our Patient and Caregiver Center at www.jcfonline.com. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - April 26, 2024 Category: Cardiology Authors: Mark Booras Source Type: research
A gene mutation turned these fish into intrepid explorers
The 240 species of cichlid fish in Africa’s Lake Tanganyika come in an astonishing variety of shapes and sizes, from the paper clip–size “sheller” that lives in abandoned snail shells to the nearly meter-long emperor cichlid. Biologists have long wondered what drove this burst of evolutionary creativity. Now, researchers have demonstrated what many suspected but had not been able to prove: that the behavior of an ancestral species—in this case, an appetite for exploration—set the stage for the rapid evolution.
The work, which appears today in
Science
, also
ties this behavioral trait to a...
Source: Science of Aging Knowledge Environment - April 25, 2024 Category: Geriatrics Source Type: research
Can science find ways to ease loneliness?
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Kelly Servick
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Ariana Remmel
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Valerie Thompson
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25 Apr 2024
One Wednesday in May 2023, a small group gathered at an outdoor café in Barcelona, Spain, sipping coffee in t...
Source: Science of Aging Knowledge Environment - April 25, 2024 Category: Geriatrics Source Type: research
