The nonalcoholic fatty liver disease (NAFLD) fibrosis score, cardiovascular risk stratification and a strategy for secondary prevention with ezetimibe
The nonalcoholic fatty liver disease fibrosis score (NFS) is comprised of unique metabolic risk indicators that may accurately predict residual cardiovascular (CV) risk in patients with established coronary disease and metabolic dysfunction. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 26, 2018 Category: Cardiology Authors: Tracey G. Simon, Kathleen E. Corey, Christopher P. Cannon, Michael Blazing, Jeong-Gun Park, Michelle L. O'Donoghue, Raymond T. Chung, Robert P. Giugliano Source Type: research

LDL extracellular vesicle coagulation protein levels change after initiation of statin therapy. Findings from the METEOR trial
Statins are thought to have pleiotropic properties, including anticoagulant effects, in addition to reducing lipoprotein (LDL) levels. Plasma extracellular vesicles (EVs) are small bilayer membrane vesicles involved in various biological processes including coagulation. Since subsets of EVs in the LDL plasma fraction (LDL-EVs) correlate with thrombin activity, we hypothesized that changes in LDL-EVs after statin therapy may differ from that of serum levels of coagulation proteins, providing insight into the effects of statins on coagulation. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 26, 2018 Category: Cardiology Authors: Laura Verbree-Willemsen, Ya-Nan Zhang, Crystel M. Gijsberts, Arjan H. Schoneveld, Jiong-Wei Wang, Carolyn S.P. Lam, Floor Vernooij, Michiel L. Bots, Linda M. Peelen, Diederick E. Grobbee, Joel S. Raichlen, Dominique P.V. de Kleijn, METEOR Study Group Source Type: research

Prognostic value of myocardial deformation imaging by cardiac magnetic resonance feature-tracking in patients with a first ST-segment elevation myocardial infarction
Scarce data are available whether cardiac magnetic resonance (CMR) assessment of myocardial deformation provides independent and incremental prognostic information in patients with ST-segment elevation myocardial infarction (STEMI). The aim of the present study was to investigate the prognostic utility of CMR feature-tracking derived left ventricular (LV) global circumferential strain (GCS) in STEMI patients. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 26, 2018 Category: Cardiology Authors: Gaetano Nucifora, Daniele Muser, Chiara Tioni, Ranjit Shah, Joseph B. Selvanayagam Source Type: research

Cardiology consultation for non-cardiac surgery: Medical and legal explorations for clinicians
Cardiologists performing preoperative cardiac evaluations for non-cardiac surgery have a unique opportunity to assess and optimize the patient's baseline and general health; determine the patient's inherent surgical risk based upon a comprehensive history, physical examination and pertinent laboratory data; ensure the patient has made an informed choice regarding surgery, and identify post-operative risks that must be considered to reduce the potential for major adverse cardiovascular events. There is always a small but inherent risk in surgical procedures. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 25, 2018 Category: Cardiology Authors: Nachiket J. Patel, Zachary R. Paterick, Matthew Schmidt, A. Jamil Tajik, Timothy E. Paterick Tags: Short communication Source Type: research

Improvement in quality indicators using NCDR ® registries: First international experience
The National Cardiovascular Data Registry (NCDR ®) Database is commonly used for quality-improvement initiatives in North America, but little is known about the application of this tool in other regions of the world. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 25, 2018 Category: Cardiology Authors: Pedro Gabriel Melo de Barros e Silva, Henrique Barbosa Ribeiro, Renato Delascio Lopes, Thiago Andrade Macedo, Fabio Conejo, Ant ônio Cláudio do Amaral Baruzzi, Mariana Yumi Okada, Jose Carlos Teixeira Garcia, Marcelo Jamus Rodrigues, Valter Furlan, Expe Tags: Short communication Source Type: research

Blunted peripheral blood supply and underdeveloped skeletal muscle in Fontan patients: The impact on functional capacity
The objective of this study was to investigate the forearm blood flow (FBF), cross-sectional area (CSA) of the thigh and functional capacity in asymptomatic clinically stable patients undergoing Fontan surgery. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 25, 2018 Category: Cardiology Authors: Aida Luiza Ribeiro Turquetto, Marcelo Rodrigues dos Santos, Ana Luiza Carrari Sayegh, Francis Ribeiro de Souza, Daniela Regina Agostinho, Patr ícia Alves de Oliveira, Yarla Alves dos Santos, Gabriela Liberato, Maria Angélica Binotto, Maria Concepcion Ga Source Type: research

Sonolysis in risk reduction of symptomatic and silent brain infarctions during coronary stenting (SONOREDUCE): Randomized, controlled trial
Silent brain infarcts can be detected on magnetic resonance imaging (MRI) in ~22% of patients after coronary angioplasty and stenting (CS). The effect of periprocedural sonolysis on the risk of new brain infarcts during CS was examined. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 25, 2018 Category: Cardiology Authors: Da ša Viszlayová, Miroslav Brozman, Kateřina Langová, Roman Herzig, David Školoudík, a SONOREDUCE Trial Group Source Type: research

Epidemiology of lower extremity artery disease in a rural setting in Benin, West Africa: The TAHES study
Cardiovascular diseases (CVD) are the leading cause of death worldwide and are mainly due to atherosclerosis [1]. Lower extremity artery disease (LEAD) is one of the main localizations of atherosclerosis, but also a risk marker of cardiovascular events. Globally, 202  million people were living with LEAD in 2010 (more than people living with HIV), and 69.7% of them in Low and Middle-Income Countries (LMIC). During 2001–2010 the number of individuals with LEAD increased respectively by 28.7% in LMIC and 13.1% in High Income Countries (HIC) [2]. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 25, 2018 Category: Cardiology Authors: Salimanou Ariyoh Amidou, Yessito Corine Houehanou, Stephan Dismand Houinato, Victor Aboyans, Arnaud Sonou, Dominique Saka, Maryse Houinato, Ileana Desormais, Julien Magne, Martin Dedonougbo Houenassi, Pierre-Marie Preux, Philippe Lacroix, TAHES Group Source Type: research

Robotic magnetic catheter navigation as a first step in the automation of the ablation procedures for ventricular arrhythmia
Radiofrequency ablation procedures have become an important treatment for ventricular arrhythmia (VA) in the absence of structural heart disease. Although acute success rates vary by study, several groups report more than 75% reduction of ventricular ectopy post-procedure [1,2]. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 25, 2018 Category: Cardiology Authors: N. Ben-Dov, D. Newman, E. Crystal Tags: Editorial Source Type: research

Patterns of clustering of the metabolic syndrome components and its association with coronary heart disease in the Multi-Ethnic Study of Atherosclerosis (MESA): A latent class analysis
The Metabolic syndrome (MetS), refers to one of the most challenging public health issues across the world. The aim of this study was to explore the clusters of participants on the basis of MetS components and determine its effect on coronary heart disease (CHD). (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 24, 2018 Category: Cardiology Authors: Seyed Mohammad Riahi, Soraya Moamer, Mahshid Namdari, Yaser Mokhayeri, Mohammad Amin Pourhoseingholi, Seyed Saeed Hashemi-Nazari Source Type: research

Percutaneous coronary intervention versus conservative treatment for non ST-segment elevation myocardial infarction in patients above 80  years of age
There is a paucity of data if there is a benefit for patients above 80  years of age with non-ST-segment elevation myocardial infarction (NSTEMI) to undergo percutaneous coronary intervention (PCI). (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 24, 2018 Category: Cardiology Authors: Peter Reinius, Linda Mellbin, Martin J. Holzmann, Anwar J. Siddiqui Source Type: research

Prognostic impact of reducing myocardial ischemia identified using ECG-gated myocardial perfusion SPECT in Japanese patients with coronary artery disease: J-ACCESS 4 study
Whether myocardial ischemia identified using myocardial perfusion imaging (MPI) can be an alternative target of coronary revascularization to reduce the incidence of cardiac events remains unclear. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 24, 2018 Category: Cardiology Authors: Mamoru Nanasato, Naoya Matsumoto, Kenichi Nakajima, Taishiro Chikamori, Masao Moroi, Kazuya Takehana, Mitsuru Momose, Hidetaka Nishina, Tokuo Kasai, Shunichi Yoda, Keisuke Kiso, Hiroyuki Yamamoto, Shigeyuki Nishimura, Akira Yamashina, Hideo Kusuoka, Atsus Source Type: research

Extracellular signal-regulated kinase (ERK) activation preserves cardiac function in pressure overload induced hypertrophy
Chronic pressure overload and a variety of mediators induce concentric cardiac hypertrophy. When prolonged, cardiac hypertrophy culminates in decreased myocardial function and heart failure. Activation of the extracellular signal-regulated kinase (ERK) is consistently observed in animal models of hypertrophy and in human patients, but its role in the process is controversial. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 24, 2018 Category: Cardiology Authors: Michael Mutlak, Michal Schlezinger-Lau, Tali Haas, Rona Shofti, Nimer Ballan, Yair E. Lewis, Mor Zuler, Yaniv Zohar, Lilac H. Caspi, Izhak Kehat Source Type: research

Low population prevalence of atrial fibrillation in rural Uganda: A community-based cross-sectional study
Atrial fibrillation (AF) is a major risk factor for stroke, which is the leading cause of cardiovascular mortality in sub-Saharan Africa. However, there is limited population-based epidemiological data on AF in sub-Saharan Africa. We sought to estimate the prevalence and correlates of AF in rural Uganda. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 24, 2018 Category: Cardiology Authors: Rahul G. Muthalaly, Bruce A. Koplan, Alfred Albano, Crystal North, Jeffrey I. Campbell, Bernard Kakuhikire, Dagmar Vo řechovská, John D. Kraemer, Alexander C. Tsai, Mark J. Siedner Source Type: research

Depression may be a risk factor for coronary heart disease in midlife women < 65  years: A 9-year prospective cohort study
Depression has been suggested as a risk factor for coronary heart disease (CHD). However, whether the risk may be affected by age is unknown. We seek to assess the difference in long-term CHD risk between younger ( (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 24, 2018 Category: Cardiology Authors: Xuezhi Jiang, Ragad Asmaro, David M. O'Sullivan, Jaymin Modi, Elizabeth Budnik, Peter F. Schnatz Source Type: research

Adiponectin/AdiopR1 signal inactivation contributes to impaired angiogenesis in mice of advanced age
The mechanism by which angiogenesis declines with aging remains largely unknown. Given that the plasma levels of adiponectin (APN) are decreased in the presence of ischemic cardiovascular disease, we explore the possible mechanisms by which APN/adiponectin receptor1 (AdipoR1) axis inactivation contributes to the decline in vascular regeneration capacity in elderly animals. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 24, 2018 Category: Cardiology Authors: Limei Piao, Chenglin Yu, Wenhu Xu, Aiko Inoue, Rei Shibata, Xiang Li, Yongshan Nan, Guangxian Zhao, Hailong Wang, Xiangkun Meng, Yanna Lei, Hiroki Goto, Noriyuki Ouchi, Toyoaki Murohara, Masafumi Kuzuya, Xian Wu Cheng Source Type: research

An ordinal prediction model of the diagnosis of non-obstructive coronary artery and multi-vessel disease in the CARDIIGAN cohort
The extent of coronary artery disease (CAD) is relevant for the evaluation and the choice of treatment of patients and consists of the severity of stenoses and their distribution within the coronary tree. Diagnosis is not easy and severe CAD should not be missed. For low-risk patients one wants to avoid the invasive angiography. We aim to propose a diagnostic prediction model of CAD respecting the degree of disease severity. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 24, 2018 Category: Cardiology Authors: Michael Edlinger, Jakob D örler, Hanno Ulmer, Maria Wanitschek, Ewout W. Steyerberg, Hannes F. Alber, Ben Van Calster Source Type: research

Is there a role for invasive assessment of the coronary microcirculation in patients with unobstructed epicardial coronary arteries in clinical practice?
Registries demonstrate that up to 49% of patients undergoing coronary angiography for investigation for angina-type chest pain, do not have significant epicardial coronary stenosis [1]. The Women's Ischemic Syndrome Evaluation (WISE) databases suggest that at least 3 to 4 million women and men with signs or symptoms suggestive of myocardial ischaemia have no obstructive coronary artery disease (CAD) [2]. Such individuals have major morbidity and incur significant ongoing healthcare costs similar to those patients with obstructive CAD, driven by repeat investigations and hospitalisation for angina [2]. (Source: Internationa...
Source: International Journal of Cardiology - May 24, 2018 Category: Cardiology Authors: Tina Z. Khan, Ranil de Silva Tags: Editorial Source Type: research

Trying to catch the octopus in the trap: Takotsubo syndrome natural history
Unto a broken heartNo other one may goWithout the high prerogativeItself hath suffered too(Emily Dickinson) (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 24, 2018 Category: Cardiology Authors: Guido Parodi, Giuseppe D. Sanna Tags: Editorial Source Type: research

Major bleeding with old and novel oral anticoagulants: How to manage it
In the last decade, the introduction of non-vitamin K antagonist oral anticoagulants (NOACs) in clinical practice has changed the therapeutic landscape in the prevention of thromboembolic events. Although NOACs compared to vitamin K antagonists (VKAs) have demonstrated a similar or slightly lower rate of major bleeding and a lower rate of intracranial or fatal bleeding, hemorrhaging still represents the main adverse effect of anticoagulant treatment. This review reports data on the rates of major bleeding with old and new oral anticoagulants. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 23, 2018 Category: Cardiology Authors: Stefania Angela Di Fusco, Fabiana Luc à, Manuela Benvenuto, Annamaria Iorio, Damiana Fiscella, Fabrizio D'Ascenzo, Andrea Madeo, Furio Colivicchi, Andrea Di Lenarda, Michele Massimo Gulizia Source Type: research

Different modalities of exercise improve macrovascular function but not microvascular function in metabolic syndrome: The RESOLVE randomized trial
To determine which modality of exercise program (endurance and/or resistance dominance) is the most effective for improving vascular function in the micro- and macrocirculation in metabolic syndrome (MetS). (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 23, 2018 Category: Cardiology Authors: Agn ès Vinet, Philippe Obert, Daniel Courteix, Robert Chapier, Bruno Lesourd, Julien Verney, Frédéric Dutheil, Guillaume Walther Source Type: research

Relationship of serum irisin levels to prevalence and progression of coronary artery calcification: A prospective, population-based study
We examined whether higher serum irisin levels are associated with lower prevalence and progression of coronary atherosclerosis. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 23, 2018 Category: Cardiology Authors: Takashi Hisamatsu, Katsuyuki Miura, Hisatomi Arima, Akira Fujiyoshi, Aya Kadota, Sayaka Kadowaki, Maryam Zaid, Naoko Miyagawa, Atsushi Satoh, Ayako Kunimura, Minoru Horie, Hirotsugu Ueshima, for the SESSA Research Group Source Type: research

MINOCA – A personalised medicine approach
Acute myocardial infarction (AMI) diagnostic criteria are well established and the management of these patients extensively detailed in evidence-based guidelines, when angiography reveals obstructive coronary artery disease. In contrast, patients experiencing ‘Myocardial Infarction with Non-Obstructive Coronary Arteries’ (MINOCA) are often neglected and represent a clinical conundrum in relation to their ongoing diagnostic evaluation and management. The diagnostic criteria for MINOCA includes (i) the universal definition of AMI [1], (ii) non-obstruct ive coronary arteries on angiography (no stenosis ≥50%), a...
Source: International Journal of Cardiology - May 23, 2018 Category: Cardiology Authors: Rosanna Tavella, Sivabaskari Pasupathy, John F. Beltrame Tags: Editorial Source Type: research

Quality of life and outcome in heart failure with preserved ejection fraction: When sex matters
The clinical manifestations of heart failure (HF) differ widely between women and men [1]. Most notably, women are usually older at presentation, have a greater burden of comorbidities, and have often a preserved left ventricular ejection fraction (LVEF); on the other hand, men have typically ischemic heart disease, reduced LVEF, and are more often on guideline-recommended medical and device treatment [2]. Moreover, among patients with HF, women have overall better prognosis that is not explained by LVEF or by the etiology of HF [3]. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 23, 2018 Category: Cardiology Authors: Claudio Passino, Alberto Aimo, Michele Emdin, Giuseppe Vergaro Tags: Editorial Source Type: research

Is there a “renal paradox” in chronic heart failure?
Chronic heart failure (CHF) and chronic kidney disease (CKD) are well known to share common risk factors and pathways (including atherosclerotic artery disease, hypertension, neurohormonal activation, endothelial dysfunction and inflammation) and are frequently coexistent, finally resulting in the “cardio-renal syndrome” [1,2]. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 23, 2018 Category: Cardiology Authors: Giuseppe Vergaro, Massimo Iacoviello Tags: Editorial Source Type: research

Heart failure and the development of atrial fibrillation in Hispanics, African Americans and non-Hispanic Whites
Atrial fibrillation (AF) is the most common cardiac arrhythmia [1], whose prevalence is increasing [1,2]. It represents a major public health problem and is closely related to stroke, mortality, decreased quality of life and a high health-care cost burden [3]. Heart failure (HF) is a growing epidemic and likely to impact 9 million US adults by 2030 [16]. AF and HF are closely linked [5], sharing similar risk factors with neurohormonal, cellular, extracellular and electrophysiologic changes of one predisposing the other [6 –8]. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 22, 2018 Category: Cardiology Authors: Eric Shulman, Tina Shah, Alon Y. Mazori, Jay J. Chudow, Faraj Kargoli, Dmitriy Nevelev, Jorge Romero, Luigi Di Biase, John Fisher, Jay Gross, Kevin J. Ferrick, Andrew Krumerman Source Type: research

High bleeding risk patients with acute coronary syndromes treated with contemporary drug-eluting stents and Clopidogrel or Ticagrelor: Insights from CHANGE DAPT
The prospective observational CHANGE DAPT study compared clopidogrel versus ticagrelor-based dual antiplatelet (DAPT) regimens in consecutive patients with acute coronary syndrome (ACS), treated with percutaneous coronary intervention (PCI) with contemporary drug-eluting stents (DES). During the ticagrelor period (TP, May 2014 –August 2015) there were more major bleedings than during the clopidogrel period (CP, December 2012–April 2014). (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 22, 2018 Category: Cardiology Authors: Paolo Zocca, Marlies M. Kok, Liefke C. van der Heijden, K. Gert van Houwelingen, Marc Hartmann, Frits H.A.F. de Man, Martin G. Stoel, J.(Hans) W. Louwerenburg, Iris L. Knottnerus, Gerard C.M. Linssen, Carine J.M. Doggen, Clemens von Birgelen Source Type: research

Biological versus mechanical heart valve prosthesis during pregnancy in women with congenital heart disease
We evaluate pregnancy outcome and anticoagulation regimes in women with mechanical and biological prosthetic heart valves (PHV) for congenital heart disease. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 22, 2018 Category: Cardiology Authors: Heleen Lameijer, Ymkje J. van Slooten, Monique R.M. Jongbloed, Martijn A. Oudijk, Marlies A.M. Kampman, Arie P. van Dijk, Marco C. Post, Barbara J. Mulder, Krystyna M. Sollie, Dirk J. van Veldhuisen, Tjark Ebels, Joost P. van Melle, Petronella G. Pieper Source Type: research

Transcatheter closure of large atrial septal defects (ASDs) in symptomatic children with device/weight ratio ≥1.5
Atrial septal defects (ASDs) can be symptomatic in small children in cases of co-morbidities. Transcatheter closure remains controversial for large defects in small children. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 22, 2018 Category: Cardiology Authors: Ali Houeijeh, Sebastien Hasco ët, Hélène Bouvaist, Khaled Hadeed, Jérôme Petit, François Godart, Alain Fraisse Source Type: research

Toll-like receptor 2: On the crossroad between immune response, cardiac fibrosis and liquorice candy
In mammals, Toll-like receptors (TLRs) represent the front line of the immune response against broad range of infective microorganisms. TLRs recognize conserved components of bacteria, viruses and other pathogens, called pathogen-associated molecular patterns (PAMPs) and initiate a cascade of molecular events activating cells of the innate immune system. The family of TLRs contains more than 10 members and individual TLR is typically involved in recognition of one specific class of PAMPs. TLR2 is an example of receptor sensing bacterial lipoproteins, therefore mice lacking TLR2 following infection with Mycobacterium, Liste...
Source: International Journal of Cardiology - May 22, 2018 Category: Cardiology Authors: Przemys ław Błyszczuk Tags: Editorial Source Type: research

Major bleeding with old and novel oral anticoagulants: How to manage it. Focus on reversal agents
Even though vitamin K antagonists (VKAs) have been employed for>50  years, there is still some uncertainty about the best strategy to reverse anticoagulation due to VKAs in cases of major bleeding. Furthermore, there is also scarce evidence about the most appropriate way to treat serious bleeding associated with non-vitamin K antagonist oral anticoagulants. This review analyses the main advantages and disadvantages of the various forthcoming therapeutic options to restore a normal coagulation status in anticoagulated patients with ongoing serious bleeding. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 21, 2018 Category: Cardiology Authors: Stefania Angela Di Fusco, Fabiana Luc à, Manuela Benvenuto, Annamaria Iorio, Damiana Fiscella, Fabrizio D'Ascenzo, Andrea Madeo, Furio Colivicchi, Andrea Di Lenarda, Michele Massimo Gulizia Source Type: research

Major bleeding with old and novel oral anticoagulants: How to manage it: Focus on reversal agents
Even though vitamin K antagonists (VKAs) have been employed for>50  years, there is still some uncertainty about the best strategy to reverse anticoagulation due to VKAs in cases of major bleeding. Furthermore, there is also scarce evidence about the most appropriate way to treat serious bleeding associated with non-vitamin K antagonist oral anticoagulants. This review analyses the main advantages and disadvantages of the various forthcoming therapeutic options to restore a normal coagulation status in anticoagulated patients with ongoing serious bleeding. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 21, 2018 Category: Cardiology Authors: Stefania Angela Di Fusco, Fabiana Luc à, Manuela Benvenuto, Annamaria Iorio, Damiana Fiscella, Fabrizio D'Ascenzo, Andrea Madeo, Furio Colivicchi, Andrea Di Lenarda, Michele Massimo Gulizia Source Type: research

Mitochondrial calcium uniporter inhibition provides cardioprotection in pressure overload-induced heart failure through autophagy enhancement
HF incurs high disease burden, and the effectiveness of known HF treatments is unsatisfactory. Therefore, seeking novel therapeutic target of HF is important. The present study aimed to investigate the role of the mitochondrial calcium uniporter (MCU) and its relationship with autophagy in overload-induced heart failure (HF). (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 20, 2018 Category: Cardiology Authors: Ziqing Yu, Ruizhen Chen, Minghui Li, Yong Yu, Yixiu Liang, Fei Han, Shengmei Qin, Xueying Chen, Yangang Su, Junbo Ge Source Type: research

Assessment of a conduction-repolarisation metric to predict Arrhythmogenesis in right ventricular disorders
This study aimed to test feasibility of an RVI-based algorithm to predict the earliest endocardial activation site of ventricular tachycardia (VT) during electrophysiological studies and occurrence of haemodynamically significant ventricular arrhythmias in follow-up. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 20, 2018 Category: Cardiology Authors: C.A. Martin, M. Orini, N. Srinivasan, J. Bhar-Amato, S. Honarbakhsh, A. Chow, M.D. Lowe, R.D. Simon, P.M. Elliott, P. Taggart, P.D. Lambiase Source Type: research

Sacubitril/valsartan: Can haemodynamic monitoring help with up-take?
This article refers to ‘Effect of Sacubitril/Valsartan on cardiac filling pressures in patients with left ventricular systolic dysfunction’, by Khan and colleagues., published in this issue on pages xxx–xxx [1]. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 20, 2018 Category: Cardiology Authors: Andrew J. Stewart Coats Tags: Editorial Source Type: research

Analysis and interpretation of the electrocardiogram by the computer
The marriage between computers and electrocardiography (ECG) dates back to the 1960s. Despite its enormous achievements, I am not sure if half a century later it can be considered a very successful marriage from the standpoint of everyday clinical electrocardiography. Numerous deep concepts based on mathematical computerised ECG analysis were developed (e.g. autonomic indices such as heart rate variability/turbulence and deceleration capacity, morphological ECG wave analysis, signal-averaged electrocardiography, beat-to-beat amplitude and morphology variability, etc.) but they all have almost zero impact on everyday ECG-ba...
Source: International Journal of Cardiology - May 20, 2018 Category: Cardiology Authors: Velislav Nikolaev Batchvarov Tags: Editorial Source Type: research

Epigenetic regulation in diabetes-associated oxidative stress and myocardial dysfunction
Diabetes is an important risk factor for ischemic heart disease and is associated with worse outcomes compared to non-diabetic patients following acute myocardial infarction (AMI). Specifically, the mortality following AMI was several times higher in diabetic patients compared to nondiabetics [1]. Emerging evidence indicates that hyperglycemia exerts long-lasting unfavorable effects on the cardiovascular system even after blood glucose normalization [2]. Short-term exposure to hyperglycemia may induce “Hyperglycemic memory” and cause long-lasting effects on myocardium [3]. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 20, 2018 Category: Cardiology Authors: Liya Yin, William M. Chilian, Feng Dong Tags: Editorial Source Type: research

Bioprosthetic valve durability: TAVR versus SAVR using different definitions of valve deterioration
Transcatheter aortic valve replacement (TAVR) has become the treatment of choice for patients with symptomatic severe aortic stenosis who are at high or extreme risk for surgical aortic valve replacement (SAVR) [1,2]. Two landmark randomised trials have recently reported data supporting the use of TAVR in intermediate surgical risk patients [3,4]. Newer generations of transcatheter valve design and optimization of patient selection, procedural planning and technique have driven continued improvements in efficacy and reduction in complication rates. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 20, 2018 Category: Cardiology Authors: David Smith Tags: Editorial Source Type: research

Use of intravenous iron in cyanotic patients with congenital heart disease and/or pulmonary hypertension
We describe our experience using intravenous ferrous carboxymaltose. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 19, 2018 Category: Cardiology Authors: Coralie Blanche, Rafael Alonso-Gonzalez, Aitor Uribarri, Aleksander Kempny, Lorna Swan, Laura Price, Stephen J. Wort, Maurice Beghetti, Konstantinos Dimopoulos Source Type: research

Use of IV iron in cyanotic patients with congenital heart disease and/or pulmonary hypertension
We describe our experience using intravenous ferrous carboxymaltose. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 19, 2018 Category: Cardiology Authors: Coralie Blanche, Rafael Alonso-Gonzalez, Aitor Uribarri, Aleksander Kempny, Lorna Swan, Laura Price, Stephen J. Wort, Maurice Beghetti, Konstantinos Dimopoulos Source Type: research

The IL-33/ST2 pathway, inflammation and atherosclerosis: Trigger and target?
The “inflammatory hypothesis” of atherosclerosis postulates that inflammatory cell signalling drives the formation, growth and ultimately the instability of atherosclerotic plaques, setting up the substrate for the thrombotic response that causes myocardial damage or infarction. The recent Canakinum ab Antiinflammatory Thrombosis Outcome Study (CANTOS) trial has been hailed as the first demonstration, ex iuvantibus, of the inflammatory hypothesis. Indeed, interleukin (IL)-1β inhibition was found to reduce cardiovascular events in patients with previous myocardial infarction and raised high-sen sitivity C-r...
Source: International Journal of Cardiology - May 19, 2018 Category: Cardiology Authors: Alberto Aimo, Paola Migliorini, Giuseppe Vergaro, Maria Franzini, Claudio Passino, Alan Maisel, Michele Emdin Source Type: research

Sitagliptin on carotid intima-media thickness in type 2 diabetes patients receiving primary or secondary prevention of cardiovascular disease: A subgroup analysis of the PROLOGUE study
Whether a dipeptidyl peptidase-4 (DPP-4) inhibitor can attenuate atherosclerosis is still controversial. Some clinical trials reported that DPP-4 inhibitors in diabetes patients without a previous history of cardiovascular (CV) events could reduce carotid intima-media thickness (IMT). However, in the PROLOGUE study, which enrolled diabetes patients both with and without previous CV events, sitagliptin failed to slow the progression of carotid IMT relative to conventional therapy. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 19, 2018 Category: Cardiology Authors: Atsushi Tanaka, Hisako Yoshida, Mamoru Nanasato, Jun-ichi Oyama, Tomoko Ishizu, Masayoshi Ajioka, Ryoji Ishiki, Makoto Saito, Yoshisato Shibata, Kohei Kaku, Koji Maemura, Yukihito Higashi, Teruo Inoue, Toyoaki Murohara, Koichi Node Tags: Short communication Source Type: research

Expressing diagnostic test performance, whose perspective — God's or Man's?
Despite advances in therapy, coronary artery disease (CAD) and myocardial infarction (MI) are leading causes of mortality in western societies and identification of patients at risk in clinical routine remains challenging [1]. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 19, 2018 Category: Cardiology Authors: Luming Shi, Qishi Zheng, Edwin Chan Tags: Editorial Source Type: research

The not-so-sweet problem of hearts aflutter: Dissecting stroke risk in atrial fibrillation with concomitant diabetes
Stroke is an important clinical condition associated with increased morbidity and mortality. Despite availability of effective oral anticoagulants (OAC), stroke prevention remains inadequate, particularly in patients with diabetes mellitus [1]. The study by XXXX and colleagues [2] in this issue of the International Journal of Cardiology examined for the first time if diabetes type 1 (T1D) or type 2 (T2D) impact differently on stroke risk specifically in patients with atrial fibrillation (AF). The investigators further explored if timing of OAC initiation once AF is diagnosed differs between T1D and T2D patients. (Source: I...
Source: International Journal of Cardiology - May 19, 2018 Category: Cardiology Authors: Anke C. Fender, Dobromir Dobrev Tags: Editorial Source Type: research

Genetic predictors of testosterone and their associations with cardiovascular disease and risk factors: A Mendelian randomization investigation
Testosterone supplementation has been linked to increased cardiovascular disease risk in some observational studies. The causal role of testosterone can be investigated using a Mendelian randomization approach. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 18, 2018 Category: Cardiology Authors: C. Mary Schooling, Shan Luo, Shiu Lun Au Yeung, Deborah J. Thompson, Savita Karthikeyan, Thomas R. Bolton, Amy M. Mason, Erik Ingelsson, Stephen Burgess Source Type: research

Increased risk of myocardial infarction with dabigatran etexilate: fact or fiction? A critical meta-analysis of over 580,000 patients from integrating randomized controlled trials and real-world studies
The question of whether the use of dabigatran etexilate is associated with a high risk of myocardial infarction (MI) remains unanswered owing to the lack of critical evidences. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 18, 2018 Category: Cardiology Authors: An-Hua Wei, Zhi-Chun Gu, Chi Zhang, Yu-Feng Ding, Dong Liu, Juan Li, Xiao-Yan Liu, Hou-Wen Lin, Jun Pu Source Type: research

Advanced interatrial block predicts new-onset atrial fibrillation and ischemic stroke in patients with heart failure: The “Bayes' Syndrome-HF” study
We examined the prevalence of IAB and whether advanced IAB could predict new-ons et AF and/or stroke in HF patients. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 18, 2018 Category: Cardiology Authors: Luis Alberto Escobar-Robledo, Antoni Bay és-de-Luna, Josep Lupón, Adrian Baranchuk, Pedro Moliner, Manuel Martínez-Sellés, Elisabet Zamora, Marta de Antonio, Mar Domingo, Germán Cediel, Julio Núñez, Evelyn Santiago-Vacas, Antoni Bayés-Genís Source Type: research

Role of oxidative stress in the process of vascular remodeling following coronary revascularization
Percutaneous coronary interventions (PCI), including balloon angioplasty and implantation of both bare metal and drug eluting coronary stents, are associated with risk of restenosis and in-stent thrombosis. A better understanding of signals that regulate cellular proliferation, neointimal formation and vessel wall thickening following PCI may contribute to identify novel preventive and therapeutic strategies aimed to reduce the atherosclerosis progression and the consequent vascular sequelae.Among the possible mechanisms, an increased level of reactive oxygen species (ROS) is associated with endothelial dysfunction and vas...
Source: International Journal of Cardiology - May 18, 2018 Category: Cardiology Authors: Giovanna Gallo, Giorgia Pierelli, Maurizio Forte, Roberta Coluccia, Massimo Volpe, Speranza Rubattu Source Type: research

Prevalence of subclinical cardiac abnormalities in patients with metal-on-metal hip replacements
Metal-on-metal (MOM) hip prostheses have a higher failure rate than conventional prostheses and leaching of cobalt and chromium has been linked to cardiomyopathy. We screened MOM subjects to evaluate if cobalt and chromium are related to subclinical cardiac dysfunction. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 17, 2018 Category: Cardiology Authors: F. Lodge, R. Khatun, R. Lord, A. John, A.G. Fraser, Z. Yousef Source Type: research

Mendelian randomization: A powerful method to determine causality of biomarkers in diseases
Assessing the influence of a marker or exposure on a given outcome is a challenging task, since a multitude of factors can influence levels of given marker, and therefore confound correlation-causation inferences. Notable exceptions are genetic markers, since those are innate and not bound to change through an individual's lifetime. Furthermore, inheritance of each trait is independent of every other according to Mendel's law of inheritance [1]. That's the principle behind Mendelian randomization (MR), a method proposed in the 80's by Katan [2] to understand if alterations in plasma cholesterol levels in cancer patients we...
Source: International Journal of Cardiology - May 17, 2018 Category: Cardiology Authors: Vinicius Tragante, Folkert W. Asselbergs Tags: Editorial Source Type: research