Impact of myocardial injury and inflammation due to ablation on the short-term and mid-term outcomes: Cryoballoon versus laser balloon ablation
Cryoballoon ablation (CBA) and laser balloon ablation (LBA) were developed as alternatives to conventional radiofrequency ablation for paroxysmal atrial fibrillation (PAF). Pathological findings after ablation such as myocardial injury and inflammation are thought to be different between CBA and LBA. However, the different impact of myocardial injury and inflammation after ablation on short- and mid-term outcomes remains unclear. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - June 11, 2021 Category: Cardiology Authors: Masamichi Yano, Yasuyuki Egami, Kohei Ukita, Akito Kawamura, Hitoshi Nakamura, Yutaka Matsuhiro, Koji Yasumoto, Masaki Tsuda, Naotaka Okamoto, Yasuharu Matsunaga-Lee, Ryu Shutta, Masami Nishino, Jun Tanouchi Source Type: research

Efficacy and safety of ticagrelor versus prasugrel in smokers and nonsmokers with acute coronary syndromes
The efficacy and safety of ticagrelor versus prasugrel according to smoking status in patients with acute coronary syndromes (ACS) are not known. We assessed the efficacy and safety of ticagrelor versus prasugrel according to smoking status in patients with ACS undergoing invasive management. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - June 11, 2021 Category: Cardiology Authors: Shqipdona Lahu, Gjin Ndrepepa, Senta Gewalt, Stefanie Sch üpke, Costanza Pellegrini, Isabell Bernlochner, Alp Aytekin, Franz-Josef Neumann, Maurizio Menichelli, Gert Richardt, Salvatore Cassese, Erion Xhepa, Sebastian Kufner, Hendrik B. Sager, Michael Jo Source Type: research

Functional heart recovery in an adult mammal, the spiny mouse
Ischemic heart disease and the resulting heart failure continue to carry high morbidity and mortality, and a breakthrough in our understanding of this disorder is needed. The adult spiny mouse (Acomys cahirinus) has evolved the remarkable capacity to regenerate full-thickness skin tissue, including microvasculature and cartilage, without fibrosis or scarring. We hypothesized that lack of scarring and resulting functional regeneration also applies to the adult Acomys heart. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - June 11, 2021 Category: Cardiology Authors: Yanfei Qi, Osama Dasa, Malcolm Maden, Ravneet Vohra, Abhinandan Batra, Glenn Walter, Joshua F. Yarrow, Juan M. Aranda, Mohan K. Raizada, Carl J. Pepine Source Type: research

Levosimendan is safe to patients with advanced heart failure and hypotension
Dear Editor: (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - June 9, 2021 Category: Cardiology Authors: Min Wang, Beibei Luo Tags: Letter to the Editor Source Type: research

Right atrial area to left atrial area ratio, a diagnostic and prognostic parameter worth studying in pulmonary hypertension due to left heart disease
We read with great interest the article entitled “Impact of the new definition of pulmonary hypertension according to world symposium of pulmonary hypertension 2018 on diagnosis of post-capillary pulmonary hypertension” [1], in which the authors described an interesting shift of cases from isolated post-capillary pulmonary hypertension (Ipc-PH ) to combined post-capillary and pre-capillary PH (Cpc-PH) due to the updated hemodynamic definition of PH [2]. Diastolic pressure gradient (DPG) might have underestimated the number of Cpc-PH cases, and the search for an ideal predictor of outcome in PH-LHD has never com...
Source: International Journal of Cardiology - June 9, 2021 Category: Cardiology Authors: Jianmin Lu, Riken Chen, Haimin Liu, Cheng Hong Tags: Letter to the Editor Source Type: research

Magnetic resonance imaging in all patients with implanted cardiac devices – Yes, We Can!
The use of magnetic resonance imaging (MRI) poses potential safety concerns for patients with implanted cardiac devices due to magnetic field –induced cardiac lead heating, which could result in myocardial thermal injury and detrimental changes in pacing properties [1]. Today, there are still issues when patients with implantable cardiac defibrillator (ICD) or cardiac pacemaker (PM) are scheduled to undergo MRI scanning, even when it ot herwise may be considered to be the most appropriate diagnostic imaging method for the patient's clinical care. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - June 9, 2021 Category: Cardiology Authors: Christian Sohns, Philipp Sommer Tags: Editorial Source Type: research

Reply to to the editor, in response to: Assessment of oxygenation after balloon pulmonary angioplasty for patients with inoperable chronic thromboembolic pulmonary hypertension
We appreciate the letter responding to our study. We are greatly encouraged as BPA operators by the suggestion that exertional oxygenation could be improved. The 6-min walk test (6MWT) is not intended to document exercise induced desaturation (EID) during exertion but is often used for this purpose [1]. Due to its simplicity, desaturation in 6MWT is proposed to evaluate EID in many patients with pulmonary hypertension or lung disease [2]. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - June 9, 2021 Category: Cardiology Authors: Yoichiro Matsuoka, Yu Taniguchi, Keisuke Miwa, Keiko Sumimoto, Yasunori Tsuboi, Hiroyuki Onishi, Kenichi Yanaka, Noriaki Emoto, Kenichi Hirata Tags: Letter to the Editor Source Type: research

Editorial Board
(Source: International Journal of Cardiology)
Source: International Journal of Cardiology - June 8, 2021 Category: Cardiology Source Type: research

Oxygenation: An important indicator for evaluating the effect of treating pulmonary hypertension
We have read with great interest of the recently published article by Matsuoka et al. [1], in which indicates that although hemodynamics of patients with inoperable chronic thromboembolic pulmonary hypertension(CTEPH) after balloon pulmonary angioplasty(BPA) nearly normalized, oxygenation did not. Moreover, exertional desaturation remained unchanged that might cause residual symptom after BPA. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - June 8, 2021 Category: Cardiology Authors: Zhenzhen Zheng, Riken Chen, Yue Zhong, Jianmin Lu, Chunying Zhuang, Haimin Liu, Nuofu Zhang, Cheng Hong Tags: Letter to the Editor Source Type: research

Cardiac amyloidosis: Watching the tip of the iceberg emerging from the “heart of the sea”
“…And now here is my secret, a very simple secret: It is only with the heart that one can see rightly; what is essential is invisible to the eye.” The Little Prince. Antoine de Saint-Exupery. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - June 8, 2021 Category: Cardiology Authors: Cristiano Amarelli, Giuseppe Limongelli Tags: Editorial Source Type: research

Mitral annular disjunction: A myocardial abnormality too?
Mitral annular disjunction (MAD) is a structural abnormality in which there is atrial displacement of the mitral valve hinge point away from the left ventricular myocardium. This can be seen as a separation between the atrial wall-mitral valve junction and the crest of the ventricular myocardium. First identified in the 1980s [1,2] MAD was originally described in association with myxomatous mitral valve disease [2] and has since been linked to increased risk of arrhythmias and sudden cardiac death [3]. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - June 5, 2021 Category: Cardiology Authors: Savalan Babapoor-Farrokhran, Gregg S. Pressman Tags: Editorial Source Type: research

Metagenomic analysis of gut microbiota reveals its role in trimethylamine metabolism in heart failure
We had previously reported an increase in trimethylamine N-oxide (TMAO) levels in patients with both compensated and decompensated heart failure (HF) and alteration in gut microbiota composition using 16S rRNA gene amplicon analysis. Although a metagenome-wide analysis showed that choline-TMA lyase levels increased in HF patients, which TMA generation pathway from choline, carnitine, or betaine contributes to the increase in TMAO levels in HF needs to be elucidated. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - June 5, 2021 Category: Cardiology Authors: Takuo Emoto, Tomohiro Hayashi, Tokiko Tabata, Tomoya Yamashita, Hikaru Watanabe, Tomoya Takahashi, Yasuhiro Gotoh, Kenjiro Kami, Naofumi Yoshida, Yoshihiro Saito, Hidekazu Tanaka, Kensuke Matsumoto, Tetsuya Hayashi, Takuji Yamada, Ken-ichi Hirata Tags: Short communication Source Type: research

Overcoming the low yield of histology for the diagnosis of cardiac sarcoidosis
Cardiac sarcoidosis (CS) is a rare type of inflammatory cardiomyopathy that presents most commonly with complete atrioventricular (AV) block, ventricular arrhythmias (VA), left ventricular systolic dysfunction (LVSD) and HF [1,2]. The hazard ratio (HR) in the population with sarcoidosis compared with a background population is 7.49 for the risk of HF, 6.95 for the risk of VA, cardiac arrest or need for an implantable cardioverter defibrillator, 3.25 for the risk of atrial fibrillation or flutter and 3.63 for the risk of mortality [3]. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - June 4, 2021 Category: Cardiology Authors: Enrico Ammirati, Paolo G. Camici, Jukka Lehtonen Tags: Editorial Source Type: research

Aortic angle distribution and predictors of horizontal aorta in patients undergoing transcatheter aortic valve replacement
Horizontal aorta (HA) is an anatomical feature that can pose significant technical challenges for the successful positioning of the bioprosthetic valve during transcatheter aortic valve replacement (TAVR). Physiological range of aortic angle (AA) is unknown; hence there is no cutoff AA for classifying HA. Moreover, patient characteristics predicting HA are under-investigated. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - June 3, 2021 Category: Cardiology Authors: Marco Moscarelli, Francesco Gallo, Guglielmo Gallone, Won-Keun Kim, J örg Reifart, Verena Veulemans, Tobias Zeus, Stefan Toggweiler, Ole De Backer, Lars Søndergaard, Antonio Mangieri, Federico De Marco, Damiano Regazzoli, Bernhard Reimers, Guillem Munta Source Type: research

Risk stratification in patients with arrhythmogenic cardiomyopathy
Meaningful risk stratification starts with a correct diagnosis. Awareness of frequent left ventricular (LV) involvement in arrhythmogenic right ventricular cardiomyopathy (ARVC) promoted the use of arrhythmogenic cardiomyopathy (ACM) as a more appropriate name for this disease. However, ARVC and ACM are not the same. ACM is broader and includes predominantly RV disease or classic ARVC, biventricular disease, and predominant LV disease (ALVC). ACM diagnosis is facilitated by the 2010 international consensus-based revised task force criteria (2010 TFC) [1]. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - June 3, 2021 Category: Cardiology Authors: Richard N.W. Hauer, Birgitta K. Velthuis Tags: Editorial Source Type: research

Coronary computed tomography angiography radiomics: A potential noninvasive tool for detecting myocardial fibrosis
Myocardial fibrosis (MF) is a common histopathological change observed in patients with hypertrophic cardiomyopathy (HCM) [1]. Currently, cardiac late gadolinium enhancement (LGE) magnetic resonance (MR) imaging is the noninvasive gold standard for the identification and quantification of MF [2]. The extent of MF as detected by LGE is an independent prognostic factor for hard events including all-cause mortality, future hospitalization, and sudden cardiac death [2,3]. However, cardiac MR (CMR) is not available for some patients who have a contraindication to CMR such as the placement of implantable cardioverter defibrillat...
Source: International Journal of Cardiology - June 3, 2021 Category: Cardiology Authors: Rui Wang, Lei Xu Tags: Editorial Source Type: research

Cost-utility analysis of heart surgeries for young adults with severe rheumatic mitral valve disease in India
Rheumatic mitral valve disease (RMVD) is a major cause of acquired valvular disease in India. We compared the cost-effectiveness of surgical treatment strategies for young adults with severe RMVD from an Indian public payer perspective. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - June 3, 2021 Category: Cardiology Authors: Jhanna Uy, Amita Girish Ketkar, Allison Portnoy, Jane J. Kim Source Type: research

Slow flow phenomenon in peripheral artery disease: Response to the editor
In comparison to coronaries where non-reflow is usually seen post intervention, authors propose slow flow phenomenon in peripheral artery disease(PAD) that occurs prior to intervention and suggest that this may contribute to variation in ordering imaging modalities due to lack of standardized approach in diagnosing and treating this disease entity. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - June 2, 2021 Category: Cardiology Authors: LaithA. Derbas, Kim Smolderen, Carlos Mena Tags: Letter to the Editor Source Type: research

Reply to the letter by Wei et al. regarding the article, “Temporal trends of acute kidney injury in patients undergoing percutaneous coronary intervention over a span of 12 years”
We appreciate the interest in our article mapping the possible determinants of risk for acute kidney injury (AKI) following percutaneous coronary intervention (PCI), and the temporal trends of the complication [1]. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - June 2, 2021 Category: Cardiology Authors: Keren Skalsky, Leor Perl Tags: Letter to the Editor Source Type: research

INOCA: Role for dynamic myocardial CT perfusion and CTCA?
In this issue of the IJC, authors of the manuscript entitled “Prevalence and disease features of myocardial ischemia with non-obstructive coronary arteries: insights from a dynamic CT myocardial perfusion imaging study” report the following main findings: (1) relatively low INOCA prevalence of 6.4% (20/314 patients); (2) INOCA patients demonstrated signif icantly more positive remodeling (40% versus 17%) compared with patients with normal (negative dCTP and CTCA) or near normal (negative dCTP and mild stenosis on CTA) findings and (3) patients with obstructive coronary artery disease demonstrate significant mor...
Source: International Journal of Cardiology - June 2, 2021 Category: Cardiology Authors: Jesse Habets Tags: Editorial Source Type: research

LncRNA KCNQ1OT1 as a miR-26a-5p sponge regulates ATG12-mediated cardiomyocyte autophagy and aggravates myocardial infarction
As a dominant cardiovascular disease, myocardial infarction (MI) causes a considerable mortality globally. KCNQ1 overlapping transcript 1 (KCNQ1OT1) was reported to be overexpressed in MI patients. However, the detailed mechanisms remain unclear. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - June 2, 2021 Category: Cardiology Authors: Jinbei Li, Yalin Tong, Yanjun Zhou, Zhanying Han, Xule Wang, Tongbin Ding, Yongsheng Qu, Zhiliang Zhang, Chao Chang, Xiaoli Zhang, Chunguang Qiu Source Type: research

Associations of time-varying obesity and metabolic syndrome with risk of incident heart failure and its subtypes: Findings from the Multi-Ethnic Study of Atherosclerosis
Most previous studies have examined associations between metabolic disorders measured at a single point in time and risk of heart failure (HF). However, there are many situations where the values of exposures vary over time before HF occurs. We aimed to examine the associations of time-varying obesity and metabolic syndrome (MetSyn) measured at multiple points in time with HF. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - June 1, 2021 Category: Cardiology Authors: Longjian Liu, Joao A.C. Lima, Wendy S. Post, Moyses Szklo Source Type: research

The role of a comprehensive two-step diagnostic evaluation to unravel the pathophysiology of MINOCA: A review
The role of cardiac magnetic resonance (CMR) in identifying mechanisms for myocardial infarction with non-obstructed coronary arteries (MINOCA) is well established. Recent reports have highlighted the potentially key role of invasive management in this diagnostic process. Intravascular ultrasound (IVUS) and optical coherence tomography (OCT) allow precise evaluation of coronary anatomy, and assessment of coronary physiology in the catheter laboratory provides information on the hemodynamic significance of sub-critical atherosclerosis and on coronary microvascular dysfunction (CMD). (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - June 1, 2021 Category: Cardiology Authors: Francesco Pelliccia, Carl J. Pepine, Colin Berry, Paolo G. Camici Source Type: research

Insight into functional tricuspid valve regurgitation pathogenesis, pathological stages, and surgical management
This article reviews the interfering factors in the function of the tricuspid valve to better identify the entity of the term “functional” and clarify its different pathological stages includin g the surgical procedures recommended in each stage. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - June 1, 2021 Category: Cardiology Authors: Anas Sarraj Asil, Pablo Diez Villanueva Source Type: research

Cardiac glycosides are not associated with increased mortality or hospitalization rates in ICD and CRT-ICD patients after adjustment for baseline-characteristics at one-year follow-up: Results from the German DEVICE registry
Despite lacking supporting randomized trials, cardiac glycosides (CGs) are widely used in heart failure and/or atrial fibrillation. Moreover, several pro- and retrospective studies and registry- data have recently raised serious concerns in terms of efficacy and safety of CGs in this field. We have therefore examined the association between CGs and clinical outcome of implantable cardioverter-defibrillator (ICD) and cardiac resynchronization (CRT-ICD) patients of the large German DEVICE registry. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - June 1, 2021 Category: Cardiology Authors: Niklas Bode, Matthias Hochadel, Dietrich Andresen, Ralf Zahn, Stefan G. Spitzer, Johannes Brachmann, Christoph Stellbrink, Werner Jung, Bernd-Dieter Gonska, Florian Reinke, Jochen Senges, Lars Eckardt Source Type: research

The black box of coronary microcirculation: Is it at the tip of the finger?
Ischemic heart disease is a major cause of morbidity and mortality, and it has become increasingly clear that ischemic heart disease is not synonymous with obstructive coronary artery disease (CAD) [1]. Ischemia and No Obstructive Coronary Arteries (INOCA) is a common condition that is associated with adverse cardiovascular outcomes, and a majority of INOCA patients are thought to have coronary vascular dysfunction, either in the epicardial vessels, the microcirculation, or both [2]. Diagnostic tools to easily identify patients at risk of future cardiovascular events would be helpful for improved primary and secondary prev...
Source: International Journal of Cardiology - June 1, 2021 Category: Cardiology Authors: Puja K. Mehta, Olga Toleva, Arshed A. Quyyumi Tags: Editorial Source Type: research

Letter by Wei et al. Regarding article, “Temporal trends of acute kidney injury in patients undergoing percutaneous coronary intervention over a span of 12 years”
We read with interest the study by Skalsky et al. [1] evaluating the temporal changes of the rates of acute kidney injury (AKI) after percutaneous coronary intervention (PCI), and exploring the potential risk factors closely related to the incidence and prognosis of AKI. Undoubtedly, their research provides strong theoretical support for clinically identifying high-risk patients with AKI, and taking preventive measures to reduce the incidence of AKI after PCI. However, if the discussion on the following issues can be increased, the conclusions will be more reliable. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 31, 2021 Category: Cardiology Authors: Jie Wei, Dalang Fang Tags: Letter to the Editor Source Type: research

A prospective study on the consequences of SARS-CoV-2 infection on the heart of young adult competitive athletes: Implications for a safe return-to-play
The COVID-19 pandemic has shocked the sports world because of the suspension of competitions and the spread of SARS-CoV-2 among athletes. After SARS-CoV-2 infection, cardio-pulmonary complications can occur and, before the resumption of sports competitions, a screening has been recommended. However, few data are available and discrepancies exist in the screening modalities. We conducted this prospective study to investigate the incidence of cardiovascular consequences following SARS-CoV-2 infection in young adult competitive athletes and the appropriate screening strategies for a safe return-to-play. (Source: International...
Source: International Journal of Cardiology - May 31, 2021 Category: Cardiology Authors: Luna Cavigli, Federica Frascaro, Francesca Turchini, Nicola Mochi, Patrizio Sarto, Stefano Bianchi, Antonio Parri, Nicol ò Carraro, Serafina Valente, Marta Focardi, Matteo Cameli, Marco Bonifazi, Flavio D'Ascenzi Source Type: research

LncRNA PART1 alleviated myocardial ischemia/reperfusion injury via suppressing miR-503-5p/BIRC5 mediated mitochondrial apoptosis
Long non-coding RNA (lncRNA) is crucial for heart development and for adult heart structural maintenance and function. Herein, we performed a study to explore the effect of lncRNA PART1 on myocardial ischemia-reperfusion (I/R) injury by targeting BIRC5 through miR-503-5p pathway. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 31, 2021 Category: Cardiology Authors: Zhihao Guo, Ming Zhao, Guowei Jia, Rui Ma, Meili Li Source Type: research

Antithrombotic strategies in elderly patients with atrial fibrillation revascularized with drug-eluting stents: PACO-PCI (EPIC-15) registry
We sought to investigate the antithrombotic regimens applied and their prognostic effects in patients over 75  years old with atrial fibrillation (AF) after revascularization with drug-eluting stents (DES). (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 29, 2021 Category: Cardiology Authors: Jose M. de la Torre Hernandez, Jos é Luis Ferreiro, Ramon Lopez-Palop, Soledad Ojeda, David Marti, Pablo Avanzas, Jose A. Linares, Alejandro Diego, Ignacio J. Amat, Miren Telleria, Belen Cid, Imanol Otaegui, Iñigo Lozano, David Serrano, Eduardo Pinar, R Source Type: research

Editorial Board
(Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 28, 2021 Category: Cardiology Source Type: research

Reply to commentary on the article entitled “Iron deficiency for prognosis in acute coronary syndrome - A systematic review and meta-analysis”
Thank you for interest in our study [1] and highlighting some of the very well recognized limitations of meta-analyses in general. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 28, 2021 Category: Cardiology Authors: Johannes Reinhold, Charikleia Papadopoulou, Ranu Baral, Vassilios S. Vassiliou Tags: Letter to the Editor Source Type: research

Sex-based differences in clinical outcomes and resource utilization of type 2 myocardial infarction
Sex-based differences in clinical outcomes have been previously well described in type 1 myocardial infarction (T1MI). However, type 2 myocardial infarction (T2MI) is more common in contemporary practice, with scarce data regarding sex-based differences of outcomes. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 28, 2021 Category: Cardiology Authors: Robert W. Ariss, Ahmed M. Elzanaty, Abdul Mannan Khan Minhas, Salik Nazir, Sajjad Gul, Neha Patel, Keerat Rai Ahuja, Angnieszka Mochon, Ehab A. Eltahawy Source Type: research

Cardiologist's approach to the diabetic patient: No further delay for a paradigm shift
Type 2 diabetes mellitus (DM) is constantly increasing worldwide and its most critical determinant of morbidity and mortality is still represented by cardiovascular (CV) complications. For years, cardiologists' approach to diabetic patients has been focused on risk factors optimization, with positive results. However, the management of DM per se was not truly considered in order to obtain prevention from major CV events, because medications used for glycemic control were not expected to gain CV benefit. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 28, 2021 Category: Cardiology Authors: Francesco Maranta, Lorenzo Cianfanelli, Carlo Gaspardone, Vincenzo Rizza, Rocco Grippo, Marco Ambrosetti, Domenico Cianflone Source Type: research

Human coronary inflammation by computed tomography: Relationship with coronary microvascular dysfunction
BackgroundA new imaging metric using coronary computed tomography angiography (CCTA), addressing the peri-coronary adipose tissue (PCAT) computed tomography (CT) attenuation, has been clinically validated. This method provides information regarding coronary inflammation. It is unclear how coronary inflammation affects microvascular function. The non-invasive evaluation of coronary flow velocity reserve is widely used in clinical practice using Doppler measurement on the left anterior descending coronary artery (CFVR-lad) during stress-echocardiography (SE). (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 27, 2021 Category: Cardiology Authors: Maria Cristina Pasqualetto, Domenico Tuttolomondo, Antonio Cutruzzol à, Giampaolo Niccoli, Damini Dey, Alessandro Greco, Chiara Martini, Concetta Irace, Fausto Rigo, Nicola Gaibazzi Source Type: research

Temporal trends and socioeconomic differences in treatment and mortality following a diagnosis of aortic stenosis
This study aims at determining the temporal trends and the socioeconomic differences in treatment and mortality following a diagnosis of aortic stenosis. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 26, 2021 Category: Cardiology Authors: Lene von Kappelgaard, Gunnar Gislason, Michael Davidsen, Ann-Dorthe Zwisler, Knud Juel Source Type: research

Reply to the letter: “Kounis syndrome: Towards a new classification”
We would like to thank Özlek et al. [1] for their kind reply to our letter [2]. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 25, 2021 Category: Cardiology Authors: Mattia Giovannini, Ioanna Koniari, Francesca Mori, Simona Barni, Elio Novembre, Nicholas George Kounis Tags: Letter to the Editor Source Type: research

Electrophysiologic and imaging evidence for an occult myopathic substrate in patients with idiopathic ventricular arrhythmias
Idiopathic VA are traditionally considered benign, although occasional patients develop an ectopy-mediated cardiomyopathy (EMC). It is unclear whether patients with idiopathic VA in the absence of left ventricular (LV) dysfunction harbor a subclinical cardiomyopathy. We aim to assess for cardiomyopathic substrate in patients with idiopathic ventricular arrhythmias (VA) using imaging and electrophysiologic markers of early fibrosis. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 25, 2021 Category: Cardiology Authors: Adam C. Lee, Wendy Strugnell, Eric Vittinghoff, Christian Hamilton-Craig, Haris M. Haqqani Source Type: research

Impact of age, sex and ethnicity on intra-cardiac flow components and left ventricular kinetic energy derived from 4D flow CMR
Four-dimensional flow cardiovascular magnetic resonance (4D flow CMR) allows quantification of left ventricular (LV) blood flow. We aimed to 1) establish reference ranges for 4D flow CMR-derived LV relative flow components and kinetic energy parameters indexed to end-diastolic volume (KEiEDV) among healthy Asian subjects, 2) assess effects of age and sex on these parameters, and 3) compare these parameters between Asian and Caucasian subjects. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 24, 2021 Category: Cardiology Authors: Xiaodan Zhao, Ru-San Tan, Pankaj Garg, Ping Chai, Shuang Leng, Jennifer Bryant, Lynette L.S. Teo, Ching Ching Ong, Rob J. van der Geest, John C. Allen, James W. Yip, Ju Le Tan, Sven Plein, Jos Westenberg, Liang Zhong Source Type: research

Where do we go from here? Beyond the MagnaSafe trial: A focus beyond a ‘safety-first’ notion. An MRI study in 500 consecutive patients
In patients with conventional pacemakers or ICD's, MRI is infrequently performed due to safety concerns. Recent reports have allayed many of these concerns. However, the additive clinical value of scanning patients with cardiac implants has not been established. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 21, 2021 Category: Cardiology Authors: Francesco Mangini, Huma Samar, Loretta Gevenosky, Ronald B. Williams, Moneal Shah, Mark Doyle, June A. Yamrozik, Richard Lombardi, Christopher A. Bonnet, Anas Mansour, Robert W.W. Biederman Source Type: research

Systemic microangiopathy in Eisenmenger syndrome – The missing link?
More than a century ago, Victor Eisenmenger published the case of a “powerfully-built” man in his thirties with longstanding cyanosis and effort-induced breathlessness, who eventually developed heart failure, oedema and died suddenly following “violent” haemoptysis. The patient, who was found to have a large ventricular septal defect (VSD) on autopsy, repres ented the first case in the scientific literature of what would posthumously be called Eisenmenger complex. Sixty years later, Paul Wood described the core pathophysiological features of Eisenmenger syndrome (ES): severe pulmonary vascular disea...
Source: International Journal of Cardiology - May 21, 2021 Category: Cardiology Authors: Ana Barradas-Pires, Teresa Segura de la Cal, Andrew Constantine, Konstantinos Dimopoulos Tags: Editorial Source Type: research

Safety and efficacy of coronary sinus narrowing in chronic refractory angina: Insights from the RESOURCE study
Refractory angina (RA) is considered the end-stage of coronary artery disease, and often has no interventional treatment options. Coronary sinus Reducer (CSR) is a recent addition to the therapeutic arsenal, but its efficacy has only been evaluated on small populations. The RESOURCE registry provides further insights into this therapy. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 21, 2021 Category: Cardiology Authors: Francesco Ponticelli, Arif A. Khokhar, Geert Leenders, Maayan Konigstein, Carlo Zivelonghi, Pierfrancesco Agostoni, Jan-Peter van Kuijk, Issameddine Ajmi, Steven Lindsay, Matja ž Bunc, Matteo Tebaldi, Alessandro Cafaro, Kevin Cheng, Alfonso Ielasi, Tiffa Source Type: research

Metabolomic correlates of coronary atherosclerosis, cardiovascular risk, both or neither. Results of the 2  × 2 phenotypic CAPIRE study
Traditional cardiovascular risk factors (RFs) and coronary artery disease (CAD) do not always run parallel. We investigated functional-metabolic correlations of CAD, RFs, or neither in the CAPIRE (Coronary Atherosclerosis in Outlier Subjects: Protective and Novel Individual Risk Factors Evaluation) 2  × 2 phenotypic observational study. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 19, 2021 Category: Cardiology Authors: Martino Deidda, Antonio Noto, Christian Cadeddu Dessalvi, Daniele Andreini, Felicita Andreotti, Eleuterio Ferrannini, Roberto Latini, Aldo P. Maggioni, Marco Magnoni, Attilio Maseri, Giuseppe Mercuro, on behalf of the CAPIRE Investigators Source Type: research

Laser for balloon uncrossable and undilatable chronic total occlusion interventions
We examined the impact of laser on the outcomes of balloon uncrossable and balloon undilatable chronic total occlusions (CTO) PCI. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 19, 2021 Category: Cardiology Authors: Judit Karacsonyi, Khaldoon Alaswad, James W. Choi, Evangelia Vemmou, Ilias Nikolakopoulos, Paul Poommipanit, Nidal Abi Rafeh, Ahmed ElGuindy, Imre Ungi, Mohaned Egred, Emmanouil S. Brilakis Source Type: research

Discharge FGF23 level predicts one year outcome in patients admitted with acute heart failure
We examined if plasma FGF23 changes during an episode of AHF, and if FGF23 holds prognostic significance in this setting. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 18, 2021 Category: Cardiology Authors: Giuseppe Vergaro, Alberto Aimo, Ester Taurino, Annamaria Del Franco, Iacopo Fabiani, Concetta Prontera, Silvia Masotti, Veronica Musetti, Michele Emdin, Claudio Passino Source Type: research

Longitudinal changes in cardiac biomarkers and outcome in heart failure: Sex-related differences
Circulating biomarkers related to disease pathways involved in heart failure (HF) development and progression may be valuable tools for the diagnosis and management of HF [1,2]. Natriuretic peptides (NPs) are cardiac protective hormones released by cardiomyocytes in response to pressure or volume overload. Measurement of B-type NP (BNP) or N-terminal pro-BNP (NT-proBNP) is recommended for risk stratification. The added value of serial measurements and the interpretation of changes in NPs over time are less well established. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 18, 2021 Category: Cardiology Authors: Alberto Aimo Tags: Editorial Source Type: research

Discharge FGF23 levels predicts one year outcome in patients admitted with acute heart failure
We examined if plasma FGF23 changes during an episode of AHF, and if FGF23 holds prognostic significance in this setting. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 18, 2021 Category: Cardiology Authors: Giuseppe Vergaro, Alberto Aimo, Ester Taurino, Annamaria Del Franco, Iacopo Fabiani, Concetta Prontera, Silvia Masotti, Veronica Musetti, Michele Emdin, Claudio Passino Source Type: research

A prospective study on the incidence of contrast-associated acute kidney injury after recanalization of chronic total coronary occlusions with contemporary interventional techniques
This study should evaluate the incidence of CA-AKI in an era of advanced strategies of recanalization techniques and identify modifiable determinants. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 17, 2021 Category: Cardiology Authors: Gerald S. Werner, Simon Lorenz, Kenji Yaginuma, Mathias Koch, Karlheinz Tischer, Juliane Werner, Thomas Keuser, Hiller Moehlis, Werner Riegel Source Type: research

Transient ST-elevation myocardial infarction versus persistent ST-elevation myocardial infarction. An appraisal of patient characteristics and functional outcome
Up to 24% of patients presenting with ST-elevation myocardial infarction (STEMI) show resolution of ST-elevation and symptoms before revascularization. The mechanisms of spontaneous reperfusion are unclear. Given the more favorable outcome of transient STEMI, it is important to obtain further insights in differential aspects. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 15, 2021 Category: Cardiology Authors: Gladys N. Janssens, Jorrit S. Lemkes, Nina W. van der Hoeven, Maarten A.H. van Leeuwen, Henk Everaars, Peter M. van de Ven, Stijn L. Brinckman, Jorik R. Timmer, Martijn Meuwissen, Joost C.M. Meijers, Arno P. van der Weerdt, Tim J.F. ten Cate, Jan J. Piek, Source Type: research

Assessment of oxygenation after balloon pulmonary angioplasty for patients with inoperable chronic thromboembolic pulmonary hypertension
In response to: Assessment of oxygenation after balloon pulmonary angioplasty for patients with inoperable chronic thromboembolic pulmonary hypertension. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 15, 2021 Category: Cardiology Authors: Craig R. Aitken, Glenn Stewart, James Walsh, Helen Seale, Norman R. Morris Tags: Letter to the Editor Source Type: research