Levosimendan or dobutamine in patients with low cardiac output syndrome: Results from meta-analysis
We read with great interest the article “Perioperative levosimendan in cardiac surgery: A systematic review with meta-analysis” by Putzu et al., where the authors found no beneficial effects of levosimendan on postoperative outcomes [1]. Putzu et al. analysed both patients with normal and reduced ejection fraction, and compared levosi mendan with placebo or no treatment [1]. Consequently, the pooled patient population was heterogeneous. We sought to determine the effects of levosimendan compared with dobutamine in the specific subgroup of patients with low cardiac output syndrome (LCOS). (Source: International ...
Source: International Journal of Cardiology - February 23, 2021 Category: Cardiology Authors: Milosz J. Jaguszewski, Aleksandra Gasecka, Krzysztof J. Filipiak, Lukasz Szarpak Tags: Letter to the editor Source Type: research

The number and activity of CD3+TCR V α7.2+CD161+ cells are increased in children with acute rheumatic fever
Acute rheumatic fever (ARF) is an autoimmune disease caused by group A β-hemolytic streptococci (GAS) and may develop into rheumatic heart disease (RHD). The pathogenesis of the ARF and RHD involves molecular mimicry and antibody-mediated mechanisms. T cell involvement is described in various stages of the disease. Mucosal associated invariant T (MAIT) cells are enric hed at the mucosa and are present in the blood and may be activated by GAS. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 22, 2021 Category: Cardiology Authors: Mehmet Ozkaya, Ali Baykan, Mustafa Cakir, Cagdas Vural, Suleyman Sunkak, Ekrem Unal, Ahmet Eken Source Type: research

Assessment of administering antithrombosis in COVID-19 patients with acute hypoxemic respiratory failure
Dear Editor: (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 22, 2021 Category: Cardiology Authors: Ping Wang, Rong Wang, Juanjuan Tang, Yang Li, Jinjun Ma Tags: Letter to the Editor Source Type: research

Work from home culture and acute cardiovascular events: A bidirectional conundrum yet to be resolved!
We read with utmost interest the article by Versaci et al. [1], and realize that while it is true that the reduced pollution levels during working from home culture have a beneficial impact on cardiovascular health, it is imperative to note its negative impact through physical inactivity, social isolation and loneliness, which are known risk factors for cardiovascular disease. Coupled with this, a surge in alcohol consumption and drug abuse that has also been evident during the lockdown, has its implications on non-communicable diseases, especially cardiovascular disease [2]. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 21, 2021 Category: Cardiology Authors: Sonali Sachdeva, Rupak Desai, Sandeep Singh, Gautam Kumar, Rajesh Sachdeva Tags: Letter to the Editor Source Type: research

Response to Zhou et al. regarding Cardiac injury prediction and lymphocyte immunity and inflammation analysis in hospitalized patients with coronavirus disease 2019 (COVID-19)
We are grateful for the response to our letter and the insight which you have provided. We agree that more data will enable clinicians and researchers to establish the risk Covid-19 poses to cardiac tissue. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 21, 2021 Category: Cardiology Authors: Alexander Tan, Daniel M. Jones, Mahmood Ahmad Tags: Letter to the Editor Source Type: research

Reply to: RV dysfunction in Covid-19 ARDS: Is there a difference in the impact of mechanical ventilation and ECMO?
We reported the pattern and degree of right ventricular (RV) dysfunction in 90 consecutive mechanically ventilated patients (42.2% VV-ECMO) with severe COVID-19 infection [1]. The authors raise the important issue of whether use of veno-venous extracorporeal membrane oxygenation (VV-ECMO) could impact RV function differently to conventional invasive ventilation. During VV ECMO, ‘rest’ ventilator settings minimise energy delivery to the lungs by reducing volumes but maintaining positive end expiratory pressure (PEEP). (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 21, 2021 Category: Cardiology Authors: Caroline Bleakley, Suveer Singh, Antonio de Marvao, Marco Morosin, Emmanouil Androulakis, Antonio Cannata, Susanna Price Tags: Letter to the Editor Source Type: research

ApoA-I mimetics improve aortic stenosis-associated left-ventricular diastolic dysfunction but fail to benefit rabbit models with normal aortic valves
Left-ventricular diastolic dysfunction (LVDD) affects about one quarter of the general population and its prevalence is expected to further increase owing to population ageing [1]. Besides coronary artery disease and arterial hypertension, aortic valve stenosis (AVS) represents a major driver of LVDD. Indeed, the elevated left-ventricular (LV) pressure imposed by the narrowed valve orifice produces interstitial fibrosis which hampers normal diastolic function, leading to overt heart failure and ultimately premature death. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 21, 2021 Category: Cardiology Authors: Simon Kraler, Florian A. Wenzl, Alexander Akhmedov, Mark C. Blaser, Elena Aikawa, Thomas F. L üscher Tags: Editorial Source Type: research

Is the Left Atrial Appendage (LAA) anatomical shape really meaningless measure for stroke risk assessment?
Since atrial fibrillation (AF) associated stroke is mostly originated from thrombogenesis in the left atrial appendage (LAA), it has been thought that the anatomical morphology of LAA would be an important contributing factor in the process of thrombogenesis [1]. However, recent studies remained controversies in terms of their association between stroke risk and LAA morphology [2 –4]. There are several reasons for these controversies. First, LAA morphology is so diverse that its classification into several pre-defined types (i.e. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 21, 2021 Category: Cardiology Authors: Seung Yong Shin, Jai-Wun Park Tags: Editorial Source Type: research

Effect of empagliflozin on cholesterol synthesis and absorption markers in patients with type 2 diabetes: Any role of DPP-4 inhibitors?
We really appreciated the results presented by Jojima and colleagues [1]. Notably, researchers demonstrated that 12-week treatment with empagliflozin resulted in a significant increase in plasma levels of campesterol, while among statin non-users it also significantly decreased plasma levels of lathosterol [1]. The observed increase in campesterol levels significantly correlated with an increase in high-density lipoprotein cholesterol (HDL-C) levels [1]. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 21, 2021 Category: Cardiology Authors: Dimitrios Patoulias, Christodoulos Papadopoulos, Michael Doumas Tags: Letter to the Editor Source Type: research

Ideal cardiovascular health in women with systemic lupus erythematosus: Association with arterial stiffness, inflammation, and fitness
Systemic Lupus Erythematosus (SLE) is closely related to cardiovascular morbidity and mortality. We aimed to examine the association of ideal cardiovascular health (ICH) with arterial stiffness, inflammation, and physical fitness in women with SLE. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 20, 2021 Category: Cardiology Authors: Alba Hern ández-Martínez, Blanca Gavilán-Carrera, José A. Vargas-Hitos, Pablo Morillas-de-Laguno, Sergio Sola-Rodríguez, Antonio Rosales-Castillo, Enrique G. Artero, José M. Sabio, Alberto Soriano-Maldonado Source Type: research

Quality indicators in the management of atrial fibrillation: the BALKAN-AF survey
The implementation of quality indicators in the atrial fibrillation (AF) care should be considered to improve quality of management and patient outcome. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 20, 2021 Category: Cardiology Authors: Monika Kozie ł, Miroslav Mihajlovic, Milan Nedeljkovic, Nikola Pavlovic, Vilma Paparisto, Ljilja Music, Elina Trendafilova, Anca Rodica Dan, Zumreta Kusljugic, Gheorghe-Andrei Dan, Gregory Y.H. Lip, Tatjana S. Potpara, on behalf of the BALKAN-AF Investig Source Type: research

Differentiation of athlete's heart and hypertrophic cardiomyopathy by the fractal dimension of left ventricular trabeculae
This study aimed to assess whether left ventricular (LV) fractal pattern could permit to differentiate athlete's heart from HCM. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 20, 2021 Category: Cardiology Authors: David Vilades, Xavier Garcia-Moll, Marta Gomez-Llorente, Sandra Pujadas, Andreu Ferrero-Gregori, Teresa Do ñate, Sonia Mirabet, Ruben Leta, Guillem Pons-Lladó, Francesc Carreras, Juan Cinca Source Type: research

Risk of stent failure in patients with diabetes treated with glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors: A nationwide observational study
Incretins are a group of glucose-lowering drugs with favourable cardiovascular (CV) effects against neoatherosclerosis. Incretins' potential effect in stent failure is unknown. The aim of this study is to determine if incretin treatment decreases the risk of stent-thrombosis (ST), and/or in-stent restenosis (ISR) after percutaneous coronary intervention (PCI) with implanted drug-eluting stents (DES). (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 20, 2021 Category: Cardiology Authors: Irene Santos-Pardo, Bo Lagerqvist, Viveca Ritsinger, Nils Witt, Anna Norhammar, Thomas Nystr öm Source Type: research

Transcatheter aortic valve replacement performed with selective telemetry monitoring: A prospective study
Telemetry monitoring (TM) with or without intensive care unit (ICU) admission is the standard of care after Transcatheter aortic valve replacement (TAVR). Regarding to improvements of the technique and procedural results, TM may be considered only in selected patients. We aimed to confirm feasibility and safety of selective TM in patients undergoing TAVR. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 20, 2021 Category: Cardiology Authors: Mariama Akodad, Eissa Aldhaheri, Gregory Marin, Fran çois Roubille, Jean-Christophe Macia, Thomas Gandet, Delphine Delseny, Laurent Schmutz, Benoit Lattuca, Pierre Robert, Arnaud Dubard, Gabriel Robert, Frederic Targosz, Eric Maupas, Bernard Albat, Guill Source Type: research

Impact of renal function on outcomes of patients with cardiac troponin elevation and non-obstructive coronary arteries
Patients with signs and symptoms suggestive of myocardial infarction and non-obstructive coronary arteries are at increased risk of adverse events. The aim of this study was to investigate the predictive role of renal function in troponin-positive patients with non-obstructive coronary arteries. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 20, 2021 Category: Cardiology Authors: Julia Steiner, Marei Kerschl, Aslihan Erbay, Youssef S. Abdelwahed, Philipp Jakob, Ulf Landmesser, David M. Leistner, Barbara E. St ähli Source Type: research

Refinement of a modified simplified Pulmonary Embolism Severity Index for elderly patients with acute pulmonary embolism
To evaluate the utility of a modified (i.e., without the variable “Age>80 years ”) simplified Pulmonary Embolism Severity Index (sPESI) in elderly patients with acute symptomatic pulmonary embolism (PE), and to derive and validate a refined version of the sPESI for identification of elderly patients at low risk of adverse events. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 19, 2021 Category: Cardiology Authors: Raquel Morillo, David Jim énez, Behnood Bikdeli, Carmen Rodríguez, Andrés Tenes, Yugo Yamashita, Takeshi Morimoto, Takeshi Kimura, Gemma Vidal, Nuria Ruiz-Giménez, Olivier Espitia, Manuel Monreal, the RIETE investigators Source Type: research

Role of pulmonary arterial capacitance in predicting mortality in patients with pulmonary hypertension: A systematic review and meta-analysis
Pulmonary arterial capacitance or compliance (PAC) has been reported as an independent predictor of mortality in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension secondary to left heart disease (pH-LHD). (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 19, 2021 Category: Cardiology Authors: Kartikeya Rajdev, Shubham Lahan, Tammy Wichman Source Type: research

Editorial Board
(Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 17, 2021 Category: Cardiology Source Type: research

Age-specific trends and outcomes of hospitalizations with acute heart failure in the United States
To analyze the national age-specific temporal trends, in-hospital outcomes and readmissions for acute heart failure (HF). (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 17, 2021 Category: Cardiology Authors: Ayman Elbadawi, Alexander Dang, Islam Y. Elgendy, Ravi Thakker, Aiham Albaeni, Mohamed A. Omer, Ahmed H. Mohamed, Syed Gilani, Khaled Chatila, Wissam Khalife, Ahmed Almustafa Source Type: research

Rationale and design of the African Cardiomyopathy and Myocarditis Registry Program: The IMHOTEP study
Heart failure (HF), the dominant form of cardiovascular disease in Africans, is mainly due to hypertension, rheumatic heart disease and cardiomyopathy. Cardiomyopathies pose a great challenge because of poor prognosis and high prevalence in low- and middle-income countries (LMICs). Little is known about the etiology and outcome of cardiomyopathy in Africa. Specifically, the role of myocarditis and the genetic causes of cardiomyopathy are largely unidentified in Africans. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 16, 2021 Category: Cardiology Authors: Sarah M. Kraus, Gasnat Shaboodien, Veronica Francis, Nakita Laing, Jacqui Cirota, Ashley Chin, Shahiemah Pandie, John Lawrenson, George A.M. Comitis, Barend Fourie, Liesl Z ühlke, Ambroise Wonkam, Helen Wainwright, Albertino Damasceno, Ana Olga Mocumbi, Source Type: research

Gender, an additional cardiovascular risk factor?
Sex and gender have been used interchangeably in the cardiovascular (CV) literature for many years. Nevertheless, these are quite different concepts, and the World Health Organisation (WHO) defines sex as a biological character assigned at birth, which depends on the combination of genetic material (sex chromosomes) and hormonal regulators (sex hormones). Sex is used as dichotomous variable (male versus female), which excludes rare chromosomic abnormalities. Gender, on the other hand, is a social construct, where boys and girls learn to become men and women, through imposed social norms, expected behaviour and established ...
Source: International Journal of Cardiology - February 16, 2021 Category: Cardiology Authors: Ana Barradas-Pires, Vennela Boyalla, Konstantinos Dimopoulos Tags: Editorial Source Type: research

A dilemma regarding the treatment of emergency percutaneous coronary intervention patients with prior contrast reaction: What can we do to prevent “one lethal reaction”?
With the advances in medical imaging for diagnostic purposes and catheter intervention, the opportunities of using iodine contrast media (ICM) have been increasing during the last few decades [1,2]. Administration of ICM may cause immediate (5 –60 min) and delayed (several hours–1 week) side effects [3]. ICM adverse reactions and symptoms vary from mild, like urticaria and nausea, to rare but severe, like cardiopulmonary arrest. Therefore, premedication with steroids for patients with prior contrast reaction may be attempted to re duce the risk of recurrent ICM reactions. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 15, 2021 Category: Cardiology Authors: Hideaki Kanazawa Tags: Editorial Source Type: research

Transient takotsubo syndrome and its recurrence: Why does it happen, why does it end, and why does it rarely reappear?
After reading a new, interesting, but limited report by Arcari et al. [1] on recurrent transient takotsubo syndrome (TTS; also known as takotsubo cardiomyopathy), I propose that we should abandon simple curiosity and face the persistent question, “What happened to my patients who had TTS?” This requires delving deeper into the pathophysiology of why the TTS initially occurred, why it stopped, and why it did not return for some time in most patients—especially given that TTS is supposedly a manifestation of common and persistent stresso rs, such as anxiety, catecholamines, adrenergic receptors, pain, depre...
Source: International Journal of Cardiology - February 15, 2021 Category: Cardiology Authors: Paolo Angelini Tags: Editorial Source Type: research

Comparison of the effect of morphine and fEntanyl in patients with acute coronary syndrome - The COMET randomized controlled trial
Dual antiplatelet therapy (DAPT) remains the cornerstone of acute coronary syndrome (ACS) management, and ticagrelor is one of the commonly used second antiplatelet agents. There is some evidence to suggest that morphine may reduce the antiplatelet effect of ticagrelor. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 15, 2021 Category: Cardiology Authors: Nagendra Boopathy Senguttuvan, Febe Suman, TamilAnbu Paneerselvam, Balakrishna Malepati, Sankaran Ramesh, Mano Vikash Vallivedu, Phalgun Badimela, Mahalakshmi Ramadoss, Meena Iyer, Preetam Krishnamurthy, Balakrishnan Vinod Kumar, Jayanthy Venkata Balasubr Source Type: research

Right ventricular strain in Anderson-Fabry disease
In this study we aimed to: 1) test the hypothesis that 2DSTE may unveil subtle RV systolic dysfunction in patients with Fabry disease; 2) investigate whether the physiologic difference between the 3-segment (RV-FWS) and the 6-segment (RV-GLS) RV strain ( ∆RV strain) is preserved in Fabry patients. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 14, 2021 Category: Cardiology Authors: Rosa Lillo, Francesca Graziani, Elena Panaioli, Erica Mencarelli, Maurizio Pieroni, Antonia Camporeale, Raffaele Manna, Ludovico Luca Sicignano, Elena Verrecchia, Antonella Lombardo, Gaetano Antonio Lanza, Filippo Crea Source Type: research

Estimating the causal effect of BMI on mortality risk in people with heart disease, diabetes and cancer using Mendelian randomization
Observational data have reported that being overweight or obese, compared to being normal weight, is associated with a lower risk for death - the “obesity paradox”. We used Mendelian randomization (MR) to estimate causal effects of body mass index (BMI) on mortality risks in people with coronary heart disease (CHD), type 2 diabetes mellitus (T2DM) or malignancy in whom this paradox has been often reported. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 13, 2021 Category: Cardiology Authors: David A. Jenkins, Kaitlin H. Wade, David Carslake, Jack Bowden, Naveed Sattar, Ruth J.F. Loos, Nicholas J. Timpson, Matthew Sperrin, Martin K. Rutter Source Type: research

Cardiac conduction abnormalities in patients with degenerated bioprostheses undergoing transcatheter aortic valve-in-valve implantations and their impact on long-term outcomes
The relationship between preoperative cardiac conduction abnormalities (CCA) and long-term outcomes after transcatheter aortic valve-in-valve implantation (TAVI-VIV) remains unclear. The aim of the study was to evaluate the effects of preoperative CCA on mortality and morbidity after TAVI-VIV and to estimate the impact of new-onset CCA on postoperative outcomes. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 13, 2021 Category: Cardiology Authors: Tomasz Stankowski, Norman Mangner, Axel Linke, Sleiman Sebastian Aboul-Hassan, Tomasz G ąsior, Anja Muehle, Volker Herwig, Axel Harnath, Mohammed Salem, Michał Szłapka, Oliver Grimmig, Soeren Just, Dirk Fritzsche, Bartłomiej Perek Source Type: research

Infective endocarditis in patients with aortic grafts
This study describes the clinical features, diagnosis and outcome of these patients. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 13, 2021 Category: Cardiology Authors: Daniel Garc ía-Arribas, Carmen Olmos, Isidre Vilacosta, Carlos Nicolás Perez-García, Carlos Ferrera, Adrián Jerónimo, Manuel Carnero, Aida Ortega Candil, Carmen Sáez, Pablo-Elpidio García-Granja, Cristina Sarriá, Javier López, José Alberto San R Source Type: research

Prognostic value of longitudinal strain and ejection fraction in Friedreich ataxia
Friedreich's ataxia (FA) is a rare autosomal recessive mitochondrial disease most commonly due to a triplet repeat expansion guanine-adenine-adenine (GAA) in the FXN gene. Cardiac disease is the major cause of death, patients with reduced left ventricular ejection fraction (LVEF) having the worse prognosis. Longitudinal strain (LS) appeared to be a better predictor of outcome than LVEF in different diseases. We compared the prognostic value of LS measured from the 4 chambers view to LVEF. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 13, 2021 Category: Cardiology Authors: L. Legrand, C. Heuze, A. Diallo, M.L. Monin, C. Ewenczyk, E. Vicaut, G. Montalescot, R. Isnard, A. Durr, F. Pousset Source Type: research

Combining sodium-glucose cotransporter 2 inhibitors and angiotensin receptor-neprilysin inhibitors in heart failure patients with reduced ejection fraction and diabetes mellitus: A multi-institutional study
Few studies investigated the combination of sodium-glucose cotransporter 2 inhibitors (SGLT2is) and angiotensin receptor-neprilysin inhibitors (ARNIs) in patients with heart failure with reduced ejection fraction (HFrEF) and type 2 diabetes mellitus (T2DM). (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 12, 2021 Category: Cardiology Authors: Fu-Chih Hsiao, Chia-Pin Lin, Ying-Chang Tung, Po-Cheng Chang, John J.V. McMurray, Pao-Hsien Chu Source Type: research

Aortic enlargement in chronic obstructive pulmonary disease (COPD) and emphysema: The multi-ethnic study of atherosclerosis (MESA) COPD study
This study assessed aorta dilation in smokers stratified by presence of COPD, emphysema and airway thickening. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 12, 2021 Category: Cardiology Authors: Kana Fujikura, Alessandra Albini, R. Graham Barr, Megha Parikh, Julia Kern, Eric Hoffman, Grant T. Hiura, David A. Bluemke, James Carr, Jo ão Lima, Erin D. Michos, Antoinette S. Gomes, Martin R. Prince Source Type: research

Differential and prognostic value of cardiovascular magnetic resonance derived scoring algorithm in cardiac tumors
To establish a scoring algorithm based on cardiovascular magnetic resonance (CMR) parameters for differentiating between benign and malignant cardiac tumors and for predicting outcome. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 11, 2021 Category: Cardiology Authors: Pengfei Yue, Ziqian Xu, Ke Wan, Xiaotong Xie, Shuming Ji, Jiayu Sun, Yucheng Chen Source Type: research

Clinical management of young competitive athletes with premature ventricular beats: A prospective cohort study
Premature ventricular beats (PVBs) are not an unusual finding and their interpretation is sometimes challenging. Unfortunately, few data on the characteristics of PVBs that correlate with the risk of an underlying heart disease are available in athletes. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 11, 2021 Category: Cardiology Authors: Alex Di Florio, Chiara Fusi, Francesca Anselmi, Luna Cavigli, Marta Focardi, Matteo Cameli, Andrea Felici, Massimo Capitani, Serafina Valente, Marco Bonifazi, Alessandro Zorzi, Domenico Corrado, Sergio Mondillo, Flavio D'Ascenzi Source Type: research

Treatment prescription, adherence, and persistence after the first hospitalization for heart failure: A population-based retrospective study on 100,785 patients
This study evaluates, in a real-world setting, to what extent the recommended therapies by international guidelines, are prescribed after a first hospitalization for heart failure (HF), and to analyse adherence and persistence, and the effect of treatment adherence on mortality and re-hospitalization. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 11, 2021 Category: Cardiology Authors: Simonetta Scalvini, Palmira Bernocchi, Stefania Villa, Anna Maria Paganoni, Maria Teresa La Rovere, Maria Frigerio Source Type: research

Effectiveness and safety of infliximab in cardiac Sarcoidosis
Immunosuppressive therapy in active cardiac sarcoidosis (CS) might prevent potential life-threatening complications. Infliximab (IFX) is a tumor necrosis factor alpha monoclonal antibody proven to be effective in refractory extracardiac sarcoidosis. It is sparsely used in CS, because of its association with worsening heart failure in prior studies. The goal of this study is to assess the effectiveness and safety of IFX in CS. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 11, 2021 Category: Cardiology Authors: A.L.M. Bakker, H. Mathijssen, J. Azzahhafi, M. Swaans, M. Veltkamp, R. Keijsers, F. Akdim, M.C. Post, J.C. Grutters Source Type: research

Cardiac magnetic resonance T1 mapping: A novel quality assurance program paving the way towards standardization and wider clinical practice
Cardiovascular magnetic resonance (CMR) is an instrumental tool for evaluating heart failure patients. It is widely regarded as the imaging gold standard for measuring chamber sizes and ejection fraction with high accuracy and reproducibility, and can characterize myocardial tissue composition to distinguish between ischemic and non-ischemic pathologies, with and without the use of gadolinium contrast [1,2]. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 11, 2021 Category: Cardiology Authors: Kanae Mukai Tags: Editorial Source Type: research

Cardiac resynchronization therapy with- or without defibrillator. Estimating the risk of arrhythmic death or assessing the likelihood of non-arrhythmic mortality?
Cardiac resynchronization therapy (CRT) became the standard of care for heart failure patients with broad QRS complex ( ≥130 ms) and reduced left ventricular function (LVEF≤35%). However, it is not easy to decide which patients will need defibrillator back-up with CRT (CRT-D) or should just receive a biventricular pacing device without ICD (CRT-P). [1,2] (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 11, 2021 Category: Cardiology Authors: Helmut U. Klein Tags: Editorial Source Type: research

Evaluation of twelve formulas for LDL-C estimation in a large, blinded, random Italian population.
In this study we analyzed the accuracy of twelve formulae for LDL-C estimation in an Italian population of 114,774 individuals. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 10, 2021 Category: Cardiology Authors: Federica Piani, Arrigo F.G. Cicero, Fulvio Ventura, Ada Dormi, Federica Fogacci, Daniela Patrono, Rita Mancini, Eric Ramazzotti, Claudio Borghi, Sergio D'Addato, on behalf of the BLIP Study Group Source Type: research

Investigation of current models of care for genetic heart disease in Australia: A national clinical audit
This sub-study of the Australian Genomics Cardiovascular Genetic Disorders Flagship sought to conduct the first nation-wide audit in Australia to establish the current practices across cardiac genetics clinics. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 10, 2021 Category: Cardiology Authors: Rachel Austin, Michael C.J. Quinn, Clifford Afoakwah, Alejandro Metke-Jimenez, Hugo Leroux, John Atherton, Jaye S. Brown, Linda J. Wornham, Ivan Macciocca, Michelle G. de Silva, Tina Thompson, Ellenore Martin, Desiree Hilton, Sophie Devery, Kathy H.C. Wu, Source Type: research

Sacubitril –valsartan treatment is associated with decrease in central apneas in patients with heart failure with reduced ejection fraction
To assess the impact of sacubitril-valsartan on apneic burden in patients with heart failure with reduced ejection fraction (HFrEF), 51 stable HFrEF patients planned for switching from an ACE-i/ARB to sacubitril-valsartan were prospectively enrolled. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 10, 2021 Category: Cardiology Authors: Claudio Passino, Paolo Sciarrone, Giuseppe Vergaro, Chiara Borrelli, Jens Spiesshoefer, Francesco Gentile, Michele Emdin, Alberto Giannoni Source Type: research

Left Atrial Strain changes in patients with breast cancer during anthracycline therapy
Cardiotoxicity has become a significant adverse effect of cancer therapy, with Anthracyclines (ANT) in particular. There is a crucial need for new imaging techniques for the early subclinical detection of cardiotoxic effect. We aimed to evaluate left atrial strain (LAS) changes during ANT therapy and to assess the correlation between LAS and the routine echocardiographic diastolic parameters. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 10, 2021 Category: Cardiology Authors: Michal Laufer-Perl, Orly Arias, Svetlana Sirota Dorfman, Guy Baruch, Ehud Rothschild, Gil Beer, Shira Peleg Hasson, Yaron Arbel, Zach Rozenbaum, Yan Topilsky, Livia Kapusta Source Type: research

Variability in utilization of diagnostic imaging tests in patients with symptomatic peripheral artery disease
This study describes the rates and variability in non-invasive and invasive imaging for patients presenting to vascular specialty clinics for symptomatic PAD. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 10, 2021 Category: Cardiology Authors: Laith A. Derbas, Krishna K. Patel, Preetham R. Muskula, Jingyan Wang, Kensey Gosch, Robert Fitridge, John A. Spertus, Kim G. Smolderen Source Type: research

Clinical impact of red blood cell transfusion on adverse clinical events in acute heart failure patients with anemia
In this article entitled “Clinical impact of red blood cell transfusion on adverse clinical events in acute heart failure patients with anemia” published in International Journal of Cardiology [1], Higuchi and colleagues explored the effect of red blood cell (RBC) transfusion on adverse events in patients with acute hea rt failure (AHF) and anemia. Admittedly, this is an interesting study, but the following issues need further explanation. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 10, 2021 Category: Cardiology Authors: Xiaohua Wang, Xiaofei Li Tags: Letter to the Editor Source Type: research

Reply to “Clinical Significance of B-type Natriuretic Peptide in Patient with Acute Decompensated Heart Failure”
We thank Dr. Toshihide Izumida, et al. for their interest regarding our article [1] and would like to response to their concerns about our study. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 10, 2021 Category: Cardiology Authors: Kazushi Sakane, Yumiko Kanzaki, Masaaki Hoshiga Tags: Letter to the Editor Source Type: research

Cardiovascular disease-specific mortality in 270,618 patients with non-small cell lung cancer
This study aimed to investigate the trend of cardiovascular disease (CVD)-specific mortality in patients with non-small cell lung cancer (NSCLC) and identify prognostic factors for CVD-specific death in stage NSCLC patients. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 10, 2021 Category: Cardiology Authors: Jin-Yu Sun, Zhen-Ye Zhang, Qiang Qu, Ning Wang, Yu-Min Zhang, Ling-Feng Miao, Ji Wang, Li-Da Wu, Ying Liu, Chang-Ying Zhang, Ru-Xing Wang Source Type: research

Editorial Board
(Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 9, 2021 Category: Cardiology Source Type: research

Changes in strain parameters at different deterioration levels of left ventricular function: A cardiac magnetic resonance feature-tracking study of patients with left ventricular noncompaction
There is a lack of cardiac MRI information on left ventricular (LV) strain and rotational parameters of left ventricular noncompaction (LVNC) patients with reduced ejection fraction (EF). Thus, we sought to use feature tracking (FT) to describe these changes at different levels of EF deterioration. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 9, 2021 Category: Cardiology Authors: Andrea Sz űcs, Anna Réka Kiss, Zsófia Gregor, Márton Horváth, Attila Tóth, Zsófia Dohy, Liliána Erzsébet Szabó, Ferenc Imre Suhai, Béla Merkely, Hajnalka Vágó Source Type: research

Clinical characteristics and outcomes in patients with echocardiographic left ventricular spontaneous echo contrast
This study aims to demonstrate the clinical characteristics and outcomes of patients with left ventricular spontaneous echo contrast (LV-SEC). (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 9, 2021 Category: Cardiology Authors: Dongjie Liang, Ruiyu Shi, Kenneth I. Zheng, Xiaodong Zhou, Qianli Zhu, Mengmeng Chen, Liangguo Wang, Ying Fang, Chenglong Xue, Weijian Huang, Peiren Shan Source Type: research

The STEMI/NonSTEMI Dichotomy needs to be replaced by Occlusion MI vs. Non-Occlusion MI
We agree with the authors that ST-elevation (STE) is a poor surrogate for acute coronary occlusion (ACO) causing myocardial infarction (MI) [1]. Unfortunately, the term “STEMI” makes us forget what we are after in the first place: ACO needing emergent reperfusion. Thus, we have been calling for a new ACO-MI (OMI for short)/non-OMI paradigm since 2018 [2]. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 9, 2021 Category: Cardiology Authors: Emre K. Aslanger, H. Pendell Meyers, Alexander Bracey, Stephen W. Smith Tags: Letter to the editor Source Type: research

Aerobic exercise and inspiratory muscle training increase functional capacity in patients with univentricular physiology after Fontan operation: A randomized controlled trial
The effect of exercise training and its mechanisms on the functional capacity improvement in Fontan patients (FP) are virtually unknown. This trial evaluated four-month aerobic exercise training and inspiratory muscle training on functional capacity, pulmonary function, and autonomic control in patients after Fontan operation. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 8, 2021 Category: Cardiology Authors: Aida Luiza Ribeiro Turquetto, Marcelo Rodrigues dos Santos, Daniela Regina Agostinho, Ana Luiza Carrari Sayegh, Francis Ribeiro de Souza, Luciana Patrick Amato, Milena Schiezari Ru Barnabe, Patr ícia Alves de Oliveira, Gabriela Liberato, Maria Angélica Source Type: research