Cardiac MRI assessed protection by direct stenting in STEMI: Effect of local and remote ischemic postconditioning
We read with great interest the well-designed paper by Saad et al. [1] online published in IJC in Dec 3, 2018. They conducted a subgroup analysis with well-matched STEMI population of a previous published randomized LIPSIA CONDITIONING trials [2], to explore the potential effect of stenting technique [direct (n  = 171) versus non-direct (n = 171)] on the myocardial protection assessed by cardiac MRI and 6-mon mortality in the univariate and multivariate Cox regression analyses. Finally, direct stenting was identified as the independent predictive factor of 6-mon mortality. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 24, 2019 Category: Cardiology Authors: Baohui Lou, Chenghui Zhou Tags: Letter to the Editor Source Type: research

How to improve patient response to cardiac resynchronization therapy?
I read the study by Strik et al. [1] about the application of activation delay vector (ADV) obtained by electrocardiographic mapping (ECM) to identify the electrical substrate for cardiac resynchronization therapy (CRT) with great interest. However, the authors neglected to discuss important findings that did not support their results and other simpler methods that might improve patient selection for CRT. In contrast to the authors' results based solely on acute response to left ventricular (LV) pacing optimization, echocardiographic latest peak radial strain-guided LV lead placement improved patient outcomes compared with...
Source: International Journal of Cardiology - April 24, 2019 Category: Cardiology Authors: Andr ás Vereckei Tags: Letter to the Editor Source Type: research

Role of ischemic conditioning and direct stenting on myocardial protection
We appreciate the interest in our article [1]. The authors raised the issue that ischemic conditioning (IC) may have also affected our study results of reduced myocardial injury and improved clinical outcome in patients with acute ST-segment elevation myocardial infarction (STEMI) undergoing direct stenting (DS) and recommend to include the IC intervention in our Cox regression analyses for identification of independent predictors of improved prognosis. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 24, 2019 Category: Cardiology Authors: Mohammed Saad, Thomas Stiermaier, Ingo Eitel Tags: Letter to the Editor Source Type: research

LncRNA NEAT1 aggravates diabetic myocardial ischemia-reperfusion injury through regulating PINK1 by targeting miR-27b
We have recently read the report by Li et al. that inhibition of PTEN-induced putative kinase 1 (PINK1)/Parkin pathway activation is an effective treatment to improve myocardial ischemia/reperfusion (MI/R) injury [1]. However, the specific mechanism by which PINK1 expression is regulated in MI/R injury has not yet been elucidated. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 24, 2019 Category: Cardiology Authors: Zhihua Ruan, Shuang Wang, Wenqian Yu, Fan Deng Tags: Letter to the Editor Source Type: research

Editorial Board
(Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 24, 2019 Category: Cardiology Source Type: research

Cognitive outcomes following coronary artery bypass grafting: A systematic review and meta-analysis of 91,829 patients
Cognitive impairments, including delirium, are common after coronary artery bypass grafting (CABG) surgery, as described in over three decades of research. Our aim was to pool estimates across the literature for the first-time, relative to time (from pre- to post-CABG) and diagnosis (cognitive impairment, delirium and dementia). (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 24, 2019 Category: Cardiology Authors: Danielle Greaves, Peter J. Psaltis, Tyler J. Ross, Daniel Davis, Ashleigh E. Smith, Monique S. Boord, Hannah A.D. Keage Source Type: research

Novel blood pressure targets in patients with high-normal levels and grade 1 hypertension: Room for monotherapy?
The 2018 European and 2017 American guidelines recommend to start antihypertensive treatment with combinations of two or more drugs in most hypertensive patients, as a consequence of the suggested more ambitious blood pressure (BP) targets (systolic BP between 130 and 120  mmHg in most patients, diastolic BP between 80 and 70 mmHg).Monotherapy, however, is still suggested as first choice in some specific classes of patients.In this article, we analyze the subgroups of hypertensive patients that should properly started and even maintained on monotherapy, with a fo cus on subjects with BP in the high-normal range or grad...
Source: International Journal of Cardiology - April 24, 2019 Category: Cardiology Authors: Massimo Volpe, Giovanna Gallo, Giuliano Tocci Source Type: research

Overwork death among doctors a challenging issue in China
China, as a country, is drawing the attention of the world, because overwork death among doctors has become a more serious problem. The death becomes critical social issues and contemporary health problems, challenging medical education and hospital management [1]. In our statistical analysis, from January 2007 and December 2018, the number of death was 110 cases, and most of which have occurred since 2012, especially in 2017. The mean ages of men and women were 41.74  ± 8.75 years and 34.71 ± 8.83 years, respectively. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 24, 2019 Category: Cardiology Authors: Xiujuan Gao, Yingjiang Xu Tags: Letter to the Editor Source Type: research

Plaque erosion: Towards precision medicine in acute coronary syndromes
“Doctors have always recognized that every patient is unique, and doctors have always tried to tailor their treatments as best they can to individuals. […] What if matching a cancer cure to our genetic code was just as easy, just as standard? What if figuring out the right dose of medicine was a s simple as taking our temperature?”– President Barack Obama, January 30, 2015. The Precision Medicine Initiative. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 23, 2019 Category: Cardiology Authors: Filippo Crea, Rocco Vergallo Tags: Editorial Source Type: research

Dual quantitative coronary angiography accurately quantifies intracoronary thrombotic burden in patients with acute coronary syndrome: Comparison with optical coherence tomography imaging
Dual quantitative coronary angiography (QCA) has been recently tested for assessment of intracoronary thrombus volume in experimental models. The present study aimed to validate dual QCA in vivo for the assessment of thrombus burden by exploring the correlations between dual QCA-thrombus volume and optical coherence tomography (OCT)-derived indices of thrombotic burden. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 22, 2019 Category: Cardiology Authors: Rocco Vergallo, Italo Porto, Giovanni Luigi De Maria, Domenico D'Amario, Gianmarco Annibali, Mattia Galli, Stefano Migliaro, Giorgio Buccimazza, Cristina Aurigemma, Antonio Maria Leone, Giampaolo Niccoli, Rajesh Kharbanda, Francesco Burzotta, Bernard D. P Source Type: research

Incidence and predictors of readmissions to non-index hospitals after transcatheter aortic valve replacement and the impact on in-hospital outcomes: From the nationwide readmission database
Whether readmission to non-index hospitals (where the initial procedure was not performed) could result in adverse outcomes and increased utilization of healthcare resources compared with readmission to index hospitals after transcatheter aortic valve replacement (TAVR) remains unclear. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 22, 2019 Category: Cardiology Authors: Tomo Ando, Oluwole Adegbala, Pedro Villablanca, Emmanuel Akintoye, Said Ashraf, Mohamed Shokr, Fayez Siddiqui, Hisato Takagi, Cindy L. Grines, Luis Afonso, Alexandros Briasoulis Source Type: research

Comments on diabetes complications severity index (DCSI) in atrial fibrillation risk prediction - Reply
I appreciate the interest of Babayigit et al. in our recent study entitled “Comparisons of changes in the adapted diabetes complications severity index and CHA2DS2-VASc score for atrial fibrillation risk stratification in patients with type 2 diabetes mellitus: a nationwide cohort study” [1]. This is an investigation about the comparative effect of dynamic changes in t wo different risk scores for the development of atrial fibrillation (AF) - the CHA2DS2-VASc score and the adapted diabetes complications severity index (DCSI) score - in patients with new onset diabetes mellitus (DM). (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 22, 2019 Category: Cardiology Authors: Wei-Syun Hu Tags: Letter to the Editor Source Type: research

Cardioprotection by PEDF: A novel form of GLUT4 membrane translocation to reduce myocardial ischemic injury
Despite the significant improvements in medical therapy, acute ST-elevation myocardial infarction is still the major contributor to mortality and morbidity worldwide. Although, timely reperfusion of the occluded coronary artery is necessary for salvage of cardiac cells and functional recovery of the heart, reperfusion of the jeopardized myocardium results in a cascade of harmful events, referred as reperfusion-injury [1]. Of importance, reperfusion-injury itself contributes to the enlargement of myocardial infarction leading to adverse left ventricle remodelling and subsequently to progressive heart failure. (Source: Inter...
Source: International Journal of Cardiology - April 22, 2019 Category: Cardiology Authors: Attila Kiss, Bruno K. Podesser Tags: Editorial Source Type: research

Real-world persistence with direct oral anticoagulants (DOACs) in na ïve patients with non-valvular atrial fibrillation
Anticoagulation therapy is central for the management of stroke in patients with non-valvular atrial fibrillation (NVAF). Persistence with oral anticoagulation is essential to prevent thromboembolic complications. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 19, 2019 Category: Cardiology Authors: Eliana Ferroni, Nicola Gennaro, Giorgio Costa, Ugo Fedeli, Gentian Denas, Vittorio Pengo, Maria Chiara Corti Source Type: research

Should cardiac CT replace echocardiography to assess RV function before tricuspid valve surgery?
Compared with the literature concerning left valvar disease [1], the data concerning tricuspid regurgitation (TR) is very limited. Recently, the prevalence, and distribution patterns of significant ( ≥moderate) TR in the Community were described by the Mayo Clinic group. TR was shown to be prevalent (≈0.55%), increasing up to 3% in patients ≥75 years, with similar prevalence to aortic stenosis [2]. Furthermore, community patients with isolated severe tricuspid valve (TV) disease, present ed with progressive right heart failure, and excess mortality even in the absence of other cardiac or systemic comorbiditie...
Source: International Journal of Cardiology - April 19, 2019 Category: Cardiology Authors: Yan Topilsky Tags: Editorial Source Type: research

Management of mitral regurgitation in patients undergoing transcatheter aortic valve replacement
Mitral regurgitation (MR) is common among patients with severe aortic stenosis (AS), but its management remains largely empirical. Conflicting results have been reported on how MR impacts on outcomes after surgical or transcatheter aortic valve replacement (TAVR), and the effects of aortic valve replacement on the evolution of MR are largely unpredictable [1]. The optimal management strategy therefore remains controversial, particularly when MR is less than severe. In the study by Abdelghani et al. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 19, 2019 Category: Cardiology Authors: Philippe Unger Tags: Editorial Source Type: research

Cardiac rehabilitation goal attainment after myocardial infarction with versus without diabetes: A nationwide registry study
Patients with first-time myocardial infarction (MI) and diabetes mellitus (DM) constitute a vulnerable subgroup of cardiovascular (CV) patients for which secondary prevention is particularly important. We investigated if patients with versus without DM differ in attaining four main lifestyle-related cardiac rehabilitation (CR) targets, one-year post-MI. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 18, 2019 Category: Cardiology Authors: John Wallert, Adam Mitchell, Claes Held, Emil Hagstr öm, Margret Leosdottir, Erik M.G. Olsson Source Type: research

Is anticoagulant therapy always indicated in “medium-risk” patients with first diagnosed atrial fibrillation? Insights from a real world, 10-year observational study
The choice of antithrombotic prophylaxis in the so-called “medium-risk” patients (i.e., CHA2DS2-VASc score = 1 in males or 2 in females) is one of the major enigmatic issues in clinical management of atrial fibrillation (AF). (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 18, 2019 Category: Cardiology Authors: Laura Bonfanti, Giuseppe Lippi, Valentina Donelli, Federica Pigna, Carlotta Saccenti, Gianfranco Cervellin Source Type: research

How to perform and report a cardiopulmonary exercise test in patients with chronic heart failure
In the present practice review, we will explain how to perform and interpret a cardiopulmonary exercise test (CPET) in heart failure patients. Specifically, we will explain why cycle ergometer should be preferred to treadmill, the type of protocol needed, and the ideal exercise duration. Thereafter, we will discuss how to interpret CPET findings and determine the parameters that should be included. We will focus specifically on: peak VO2 (absolute value and a percentage of its predicted value), exercise duration, respiratory exchange ratio, peak work rate, heart rate, O2 pulse, end-tidal carbon dioxide pressure (PetCO2), P...
Source: International Journal of Cardiology - April 18, 2019 Category: Cardiology Authors: Piergiuseppe Agostoni, Daniel Dumitrescu Tags: Review Source Type: research

Types of anatomic relationship between left main coronary artery and pulmonary sinus of Valsalva: Implications for balloon pulmonary angioplasty and catheter ablation in the pulmonary root
Concerns have been raised upon the risk of left main coronary artery (LMCA) injury when balloon angioplasty or ablation is performed within the pulmonary sinus of Valsalva (PSV). (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 17, 2019 Category: Cardiology Authors: Xiaonan Dong, Qi Sun, Min Tang, Shu Zhang Source Type: research

“Treat-to-close”: Non-repairable ASD-PAH in the adult
Adults presenting with an unrepaired atrial septal defect and pulmonary arterial hypertension (ASD-PAH) are typically classified as “correctable” or “non-correctable”. The use of directed PAH medical therapy in non-correctable ASD-PAH leading to favorable closure candidacy, repair status and long-term follow-up is not well studied. We therefore sought to characterize response to PAH targeted therapy in ‘non-correctable ’ ASD-PAH. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 17, 2019 Category: Cardiology Authors: Elisa A. Bradley, Naser Ammash, Sara C. Martinez, Kelly Chin, Camden Hebson, Harsimran S. Singh, Jamil Aboulhosn, Jasmine Grewal, Joseph Billadello, Murali M. Chakinala, Curt J. Daniels, Ali N. Zaidi Source Type: research

Prognosis of Streptococcus pneumoniae endocarditis in France, a multicenter observational study (2000 –2015)
Streptococcus pneumoniae is responsible for (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 17, 2019 Category: Cardiology Authors: Amandine P érier, Mathieu Puyade, Matthieu Revest, Pierre Tattevin, Louis Bernard, Adrien Lemaignen, David Boutoille, Joseph Allal, France Roblot, Blandine Rammaert Source Type: research

Recurrent arterial occlusive events in patients with chronic myeloid leukemia treated with second- and third-generation tyrosine kinase inhibitors and role of secondary prevention
Risk of death is particularly high in patients with a previous history of arterial occlusive events (AOEs) and the probability for a recurrent event is around 20%. Little is known about recurrent AOE and the role of secondary prevention in patients with Chronic Myeloid Leukemia (CML) with previous AOE, treated with second- and third-generation tyrosine kinase inhibitors (2ndG/3rdG TKIs), nilotinib, dasatinib, bosutinib and ponatinib. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 17, 2019 Category: Cardiology Authors: Giovanni Caocci, Olga Mulas, Massimiliano Bonifacio, Elisabetta Abruzzese, Sara Galimberti, Ester Maria Orlandi, Alessandra Iurlo, Mario Annunziata, Luigiana Luciano, Fausto Castagnetti, Antonella Gozzini, Fabio Stagno, Gianni Binotto, Patrizia Pregno, Fr Tags: Short communication Source Type: research

Correlation between intracoronary physiology and myocardial perfusion imaging in patients with severe aortic stenosis
Aortic stenosis (AS) is frequently associated with coronary artery disease (CAD). However, the best tool to functionally assess CAD in AS remains undetermined. Fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) have never been validated in AS. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 17, 2019 Category: Cardiology Authors: Roberto Scarsini, Rosaria Cantone, Gabriele Venturi, Giovanni Luigi De Maria, Andrea Variola, Paolo Braggio, Mattia Lunardi, Gabriele Pesarini, Marco Ferdeghini, Anna Piccoli, Mauro Feola, Rajesh K. Kharbanda, Adrian P. Banning, Flavio Ribichini Tags: Short communication Source Type: research

Evaluation of ventriculo-arterial coupling in ST elevation myocardial infarction with left ventricular dysfunction treated with levosimendan
In this study, we aimed at investigating the role of levosimendan on cardiovascular determinants of contractility and afterload in patients with AHF following STEMI treated with percutaneous coronary intervention (PCI). (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 17, 2019 Category: Cardiology Authors: Paolo Trambaiolo, Pietro Bertini, Nunzia Borrelli, Marco Poli, Silvio Romano, Giuseppe Ferraiuolo, Maria Penco, Fabio Guarracino Source Type: research

Atrial high-rate episodes and thromboembolism in patients without atrial fibrillation: The West Birmingham Atrial Fibrillation Project
Patients with cardiac implantable electronic device (CIED) developing atrial high-rate episodes (AHRE) have a significant risk of thromboembolic events (TEs), but risk factors have been scarcely investigated. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 17, 2019 Category: Cardiology Authors: Yan-Guang Li, Kazuo Miyazawa, Daniele Pastori, Orsolya Szekely, Farhan Shahid, Gregory Y.H. Lip Source Type: research

Prediction and prevention of sudden cardiac death in transposition of the great arteries: A step closer
Recently, Khairy et al. investigated the pathophysiology of sudden cardiac death (SCD) in patients with dextro-transposition of the great arteries (d-TGA) and Mustard or Senning baffles [1]. Based on his findings he postulated that myocardial oxygen supply/demand mismatch may provoke ischemia related tachyarrhythmias leading to SCD. In the current issue of this journal, Khairy et al. provide for the first time histopathological evidence in favor of this theory [2]. In the last decades, drastic changes in management of patients with d-TGA have resulted in excellent survival rates and improvements in quality of life. (Source...
Source: International Journal of Cardiology - April 17, 2019 Category: Cardiology Authors: R.K. Kharbanda, N.M.S. De Groot Tags: Editorial Source Type: research

Epicardial adipose tissue GLP-1 receptor is associated with genes involved in fatty acid oxidation and white-to-brown fat differentiation: A target to modulate cardiovascular risk?
Epicardial adipose tissue (EAT) is a risk factor for cardiovascular diseases. Glucagon-like peptide 1 analogs (GLP-1A) may have beneficial cardiovascular effects and reduce EAT, possibly throughout targeting GLP-1 receptor (GLP-1R). Nevertheless, the role of EAT GLP-1R, GLP-2R and their interplay with EAT genes involved in adipogenesis and fatty acid (FA) metabolism are unknown. We analyzed whether EAT transcriptome is related to GLP-1R/GLP-2R gene expression, and GLP-1/GLP-2 plasma levels in coronary artery disease patients (CAD). (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 15, 2019 Category: Cardiology Authors: Elena Dozio, Elena Vianello, Alexis E. Malavazos, Lorenza Tacchini, Gerd Schmitz, Gianluca Iacobellis, Massimiliano M. Corsi Romanelli Source Type: research

Myocardial Infarction with Non Obstructive Coronary Arteries (MINOCA): Are there ethnic differences?
The diagnosis and management of acute myocardial infarction (MI) is well documented in guidelines from professional societies [1,2]. These guideline recommendations are based on the premise that atherothrombosis is the underlying pathophysiological process responsible for the acute MI presentation; a concept that is consistent with the presence of obstructive coronary artery disease (CAD) on coronary angiography. Accordingly, therapies targeting the atherothrombotic process have been evaluated and shown to be of benefit with a large evidence-base. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 15, 2019 Category: Cardiology Authors: Sivabaskari Pasupathy, Rosanna Tavella, John F. Beltrame Tags: Editorial Source Type: research

Risk of contrast-induced nephropathy in patients undergoing complex percutaneous coronary intervention
Complex percutaneous coronary intervention (PCI) is associated with increased procedural challenges and high contrast load. We aimed to evaluate the association between complex PCI and contrast-induced nephropathy (CIN). (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 14, 2019 Category: Cardiology Authors: Lorenzo Azzalini, Enrico Poletti, Francesca Lombardo, Alessandra Laricchia, Alessandro Beneduce, Silvia Moscardelli, Barbara Bellini, Davide Maccagni, Alberto Cappelletti, Marco B. Ancona, Mauro Carlino, Alaide Chieffo, Antonio Colombo, Matteo Montorfano Source Type: research

Electrical storm is associated with impaired prognosis compared to ventricular tachyarrhythmias
Because data on electrical storm (ES) is limited, this study sought to compare the prognostic outcome of patients with ES to those with ventricular tachyarrhythmias (VTA) on mortality, rehospitalization and major adverse cardiac events (MACE). (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 12, 2019 Category: Cardiology Authors: Michael Behnes, Julian M üller, Dominik Ellguth, Tobias Schupp, Gabriel Taton, Linda Reiser, Thomas Reichelt, Armin Bollow, Seung-Hyun Kim, Christian Barth, Ahmad Saleh, Jonas Rusnak, Kathrin Weidner, Christoph A. Nienaber, Kambis Mashayekhi, Muharrem Ak Source Type: research

International expert consensus on a scientific approach to training novice cardiac resynchronization therapy implanters using performance quality metrics
Pacing and Cardiac Resynchronization Therapy (CRT) procedural training for novice operators usually takes place in-vivo and methods vary across countries/institutions. No common system exists to objectively assess trainee ability to perform required tasks at predetermined performance levels prior to in-vivo practice. We sought to characterize and validate with experts a reference approach to pacing/CRT implants based on objective and explicit performance quality metrics, for the development of a reproducible, simulation-based, training curriculum aiming to operator proficiency. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 12, 2019 Category: Cardiology Authors: Jorio Mascheroni, Llu ís Mont, Martin Stockburger, Ashish Patwala, Hartwig Retzlaff, Anthony G. Gallagher, CRT-PROBIT group Source Type: research

Editorial Board
(Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 11, 2019 Category: Cardiology Source Type: research

New-generation drug eluting stent vs. bare metal stent in saphenous vein graft – 1 year outcomes by a propensity score ascertainment (SVG Baltic Registry)
Data regarding the efficacy of the percutaneous coronary intervention (PCI) with new-designed drug-eluting stent (new-DES) vs. bare metal stent (BMS) of saphenous vein grafts (SVG) stenosis is scarce. The primary objective was to compare one-year clinical outcomes of PCI in stenosis of SVG using new-DES vs. BMS in a real-world population. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 11, 2019 Category: Cardiology Authors: Wojciech Wa ńha, Maksymilian Mielczarek, Tomasz Roleder, Szymon Ładziński, Marek Milewski, Natasza Gilis-Malinowska, Michał Chmielecki, Dariusz Ciećwierz, Witold Bachorski, Piotr Kunik, Agata Trznadel, Klaudia Męcka, Alicja Genc, Rafał Januszek, Pi Source Type: research

Effect of early, individualised and intensified follow-up after open heart valve surgery on unplanned cardiac hospital readmissions and all-cause mortality
The objective was to investigate the effect of individualised follow-up after open heart valve surgery on a composite endpoint of first unplanned cardiac hospital readmission or all-cause mortality within 180  days of discharge. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 11, 2019 Category: Cardiology Authors: Britt Borregaard, Jordi Sanchez Dahl, Lars Peter Sch ødt Riber, Ola Ekholm, Kirstine Lærum Sibilitz, Marc Weiss, Jan Sørensen, Selina Kikkenborg Berg, Jacob Eifer Møller Source Type: research

Elevated non-invasive liver fibrosis markers and risk of liver carcinoma in adult patients after repair of tetralogy of Fallot
Congestive hepatopathy and hepatocellular carcinoma is a serious complication after Fontan procedure. Liver fibrosis due to hepatic congestion could occur also in adult patients after repair of tetralogy of Fallot (rTOF). However, the incidence and severity remain unclear. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 11, 2019 Category: Cardiology Authors: Kenichiro Yamamura, Ichiro Sakamoto, Eiji Morihana, Yuichiro Hirata, Hazumu Nagata, Yuzo Yamasaki, Yukihiko Okumura, Kenichi Kohashi, Kazuhiro Koto, Hiroyuki Tsutsui, Shouichi Ohga Source Type: research

Sex-specific differences regarding seasonal variations of incidence and mortality in patients with myocardial infarction in Germany
Seasonal variation regarding the incidence and the short-term mortality of acute myocardial infarction (MI) was frequently reported, but data about sex-specific differences are sparse. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 11, 2019 Category: Cardiology Authors: Karsten Keller, Lukas Hobohm, Thomas M ünzel, Mir Abolfazl Ostad Source Type: research

N-terminal pro-B-type natriuretic peptide in chronic heart failure: The impact of sex across the ejection fraction spectrum
The aim was to assess sex-specific differences in N-terminal B-type natriuretic peptide (NT-proBNP) regarding concentrations, predictors of high concentrations, and prognostic role, in a large and unselected population with chronic heart failure (HF) with preserved (HFpEF), mid-range (HFmrEF), and reduced ejection fraction (HFrEF). (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 11, 2019 Category: Cardiology Authors: Ulrika Ljung Fax én, Lars H. Lund, Nicola Orsini, Anna Strömberg, Daniel Andersson, Cecilia Linde, Ulf Dahlström, Gianluigi Savarese Source Type: research

Statin therapy for Takayasu Arteritis
First marketed>30  years ago, statins quickly became a therapeutic cornerstone in coronary artery disease primary and secondary prevention. Statins exert their low density lipoprotein-cholesterol lowering effect through inhibition of 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase, the rate-limiting enzy me in the L-mevalonate pathway. During the last several years, knowledge on statins pharmacologic properties has constantly expanded, unveiling a surprisingly wide array of metabolic interactions which accounts, at least in part, for their complex biologic effects in vivo [1]. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 11, 2019 Category: Cardiology Authors: Fulvio Salvo, Stefano Franchini Tags: Editorial Source Type: research

Prospective validation of current quantitative electrocardiographic criteria for ST-elevation myocardial infarction
Rapid and reliable diagnosis of ST-elevation myocardial infarction (STEMI) as a surrogate for acute coronary occlusion is critical for early reperfusion therapy. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 11, 2019 Category: Cardiology Authors: Petra Hillinger, Ivo Strebel, Roger Ab ächerli, Raphael Twerenbold, Karin Wildi, Denise Bernhard, Thomas Nestelberger, Jasper Boeddinghaus, Patrick Badertscher, Desiree Wussler, Luca Koechlin, Tobias Zimmermann, Christian Puelacher, Maria Rubini Gimenez, Source Type: research

Is sex associated with adverse outcomes after percutaneous coronary intervention for CTO?
Conflicting results have been reported regarding sex differences in percutaneous coronary intervention (PCI), but their potential influence on clinical outcomes after chronic total coronary occlusion (CTO) PCI remains unknown. We aimed to identify sex-related differences in long-term clinical outcomes after CTO PCI. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 10, 2019 Category: Cardiology Authors: Mariama Akodad, Marco Spaziano, Carlos J. Garcia-Alonso, Yves Louvard, Francesca Sanguineti, Philippe Garot, Thomas Hovasse, Thierry Unterseeh, Bernard Chevalier, Thierry Lef èvre, Hakim Benamer Source Type: research

ST-segment elevation and cardiac magnetic resonance imaging findings in myocardial infarction with non-obstructive coronary arteries
Patients with myocardial infarction and non-obstructive coronary arteries (MINOCA) may present with or without ST-elevation (STE) on the electrocardiogram (ECG). Previous studies have shown that STE was associated with higher risk of early mortality and long-term major adverse coronary events, and that cardiac magnetic resonance imaging (CMR) can help to determine whether the cause of a MINOCA presentation is ischemic or non-ischemic. We set out to determine the relationship between STE and CMR findings in patients presenting with MINOCA. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 10, 2019 Category: Cardiology Authors: Anais Hausvater, Sivabaskari Pasupathy, Per Tornvall, Himali Gandhi, Rosanna Tavella, John Beltrame, Stefan Agewall, Christina Ekenb äck, Elin Bacsovics Brolin, Judith S. Hochman, Olov Collste, Harmony R. Reynolds Tags: Short communication Source Type: research

Long term cardiovascular magnetic resonance phenotyping of anthracycline cardiomyopathy
This study sought to describe the phenotype of long-term anthracycline cardiomyopathy, the prevalence of myocardial fibrosis and its association with cardiac remodeling, systolic function and clinical outcomes in the. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 10, 2019 Category: Cardiology Authors: Iwan Harries, Giovanni Biglino, Anna Baritussio, Estefania De Garate, Amardeep Dastidar, Juan Carlos Plana, Chiara Bucciarelli-Ducci Source Type: research

Plasma FABP4 levels are associated with left atrial fat volume in persistent atrial fibrillation and predict recurrence after catheter ablation
Imaging techniques have shown the association between left atrial adipose tissue (LAAT) volume and atrial fibrillation (AF) risk. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 10, 2019 Category: Cardiology Authors: J. Nicolas Lopez Canoa, Aurora Baluja, Marinela Couselo-Seijas, Anaberta Bermudez Naveira, Laila Gonzalez-Melchor, Adriana Rozados, Luis Mart ínez-Sande, Javier García-Seara, X. Alberte Fernandez-Lopez, A.L. Fernandez, Jose Ramon Gonzalez-Juanatey, Soni Source Type: research

Added value of exercise test findings beyond traditional risk factors for cardiovascular risk stratification
Functional aerobic capacity (FAC) determined by treadmill exercise testing (TMET) is associated with cardiovascular (CV) disease mortality independent of traditional CV risk factors and is a potentially underutilized tool. The purpose of this study was to determine added prognostic value of reduced FAC and other exercise test abnormalities beyond CV risk factors for predicting total and CV mortality. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 10, 2019 Category: Cardiology Authors: Amanda R. Bonikowske, Francisco Lopez-Jimenez, Maria Irene Barillas-Lara, Ahmad Barout, Sonia Fortin-Gamero, Nora Sydo, Thomas G. Allison Source Type: research

Catheter based therapies in massive pulmonary embolism
Pulmonary embolism (PE) is the third most common cardiovascular disease claiming 100,000 deaths annually in the United States (U.S.). It also the leading cause of preventable deaths in hospitalized adults [1]. Risk stratification remains the essential first step to tailor PE treatment. Majority of the radiologically diagnosed acute PE are low risk with mortality rate (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 10, 2019 Category: Cardiology Authors: Nileshkumar J. Patel, Varunsiri Atti, Mir B. Basir, Vikas Aggarwal Source Type: research

Sugars make the difference – Glycosylation of cardiodepressant antibodies regulates their activity in dilated cardiomyopathy
Cardiodepressant antibodies contribute to cardiac dysfunction in dilated cardiomyopathy (DCM). Changes in immunoglobulin G (IgG) glycosylation modulate the activity of various autoimmune diseases and influence disease activity as well as severity of various autoimmune diseases. We hypothesized that alterations in IgG glycosylation are involved in the disease course of DCM. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 9, 2019 Category: Cardiology Authors: Yvonne Reinke, Stephanie K önemann, Bishwas Chamling, Stefan Gross, Kerstin Weitmann, Wolfgang Hoffmann, Karin Klingel, Matthias Nauck, Jens Fielitz, Marcus Dörr, Stephan B. Felix Tags: Short communication Source Type: research

High-sensitive cardiac Troponin T and exercise stress test for evaluation of angiographically significant coronary disease
Exercise stress test (EST) has a moderate precision for diagnosis of CAD and could potentially obtain improved accuracy if adding a reliable cardiac biomarker to the test. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 8, 2019 Category: Cardiology Authors: Joanna Cwikiel, Ingebj ørg Seljeflot, Morten W. Fagerland, Kristian Wachtell, Harald Arnesen, Eivind Berge, Arnljot Flaa Source Type: research

Right ventricular pressure overload alters cardiac lipid composition
Right ventricular (RV) failure due to pressure load is an important determinant of clinical outcome in pulmonary hypertension, congenital heart disease and left ventricular failure. The last decades it has become clear that metabolic dysregulation is associated with the development of RV-failure. However, underlying mechanisms remain to be unraveled. Recently, disruption of intracardiac lipid content has been suggested as potential inducer of RV failure. In the present study, we used a rat model of RV-dysfunction and aimed to obtain insight in temporal changes in RV-function, -remodelling and -metabolism and relate this to...
Source: International Journal of Cardiology - April 8, 2019 Category: Cardiology Authors: A.M.C. Koop, Q.A.J. Hagdorn, G.P.L. Bossers, T. van Leusden, A. Gerding, M. van Weeghel, F.M. Vaz, D.P.Y. Koonen, H.H.W. Sillj é, R.M.F. Berger, B. Bartelds Source Type: research

Early invasive assessment of the coronary microcirculation predicts subsequent acute rejection after heart transplantation
This study aimed to investigate baseline clinical and diagnostic variables associated with subsequent AAR during the first year post-transplant, especially focusing on early physiologic and anatomic measures. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 8, 2019 Category: Cardiology Authors: Kozo Okada, Yasuhiro Honda, Helen Luikart, Paul G. Yock, Peter J. Fitzgerald, Alan C. Yeung, Hannah A. Valantine, Kiran K. Khush, William F. Fearon Source Type: research