Editorial Board
(Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 27, 2022 Category: Cardiology Source Type: research

Novel multiple sclerosis agents-associated cardiotoxicity: A real-world pharmacovigilance study
Background:Emerging novel therapeutics have been developed to hamper the progression of multiple sclerosis (MS). However, the adverse events related to these new agents remain largely unknown. Therefore, we sought to investigate the cardiovascular complications of these drugs.Methods: Utilizing data from the U.S. food and drug administration (FDA) adverse events reporting system (FAERS), we comprehensively evaluated the cardiovascular complications of the newly FDA-approved anti-MS modifying therapies approved since 2015. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 25, 2022 Category: Cardiology Authors: Zaki Al-Yafeai, Alexander Carvajal-Gonz ález, Hamzah Abduljabar, Muhammed Arvas, Shaan Patel, Neev Patel Source Type: research

Revisiting QT prolongation in acute rheumatic fever – Relevance for hydroxychloroquine treatment
In-vitro evidence suggests hydroxychloroquine could be a potential immunomodulator for the inflammatory carditis of acute rheumatic fever (ARF). Hydroxychloroquine used as an anti-inflammatory agent has a low side effect profile but its use in the Covid-19 pandemic raised concerns about QTc interval prolongation and cardiac arrhythmias. The prolongation of QTc in ARF appears benign but has not been widely studied. We aim to report QTc intervals in a contemporary ARF population and consider implications for hydroxychloroquine use in ARF. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 25, 2022 Category: Cardiology Authors: Fiona Perelini, Joshua Agnew, Jonathan R. Skinner, Dug Yeo Han, Ross Nicholson, Nigel Wilson Tags: Short communication Source Type: research

SARS-CoV-2 infects human cardiac myocytes promoted by inflammation and oxidative stress
The respiratory illness triggered by severe acute respiratory syndrome virus-2 (SARS-CoV-2) is often particularly serious or fatal amongst patients with pre-existing heart conditions. Although the mechanisms underlying SARS-CoV-2-related cardiac damage remain elusive, inflammation (i.e. ‘cytokine storm’) and oxidative stress are likely involved. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 25, 2022 Category: Cardiology Authors: Melina Tangos, Heidi Budde, Detmar Kolijn, Marcel Sieme, Saltanat Zhazykbayeva, M ária Lódi, Melissa Herwig, Kamilla Gömöri, Roua Hassoun, Emma Louise Robinson, Toni Luise Meister, Kornelia Jaquet, Árpád Kovács, Julian Mustroph, Katja Evert, Nina B Source Type: research

Depression and ischemic heart disease
Depression is common in patients with ischemic heart disease, and depressed patients are more likely to develop atherosclerosis and experience major cardiac events compared with the general population. The underlying pathophysiological mechanisms of these two diseases are highly interwoven and include an increased release of stress hormones, dysregulation of the autonomic nervous system, alterations of pathways related to primary and secondary hemostasis, endothelial dysfunction, and higher level of residual inflammation. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 25, 2022 Category: Cardiology Authors: Carlo A. Pivato, Rishi Chandiramani, Marija Petrovic, Johny Nicolas, Alessandro Spirito, Davide Cao, Roxana Mehran Tags: Review Source Type: research

When should patients with acute myocardial infarction undergo CABG? A question much in need of a randomized clinical trial?
A significant fraction of patients presenting with non-ST-elevation myocardial infarction (NSTEMI) will undergo coronary artery bypass grafting (CABG) for revascularization which is associated with increased mortality (1) compared to elective surgery. However, the optimal timing of when to perform CABG following myocardial infarction remains a matter of contention. The benefits of early revascularization include reducing ischemia and infarct expansion and lower utilization of resources. However, these are counterbalanced by the potential risks of early CABG that include increased hemodynamic instability, arrhythmias and bl...
Source: International Journal of Cardiology - May 25, 2022 Category: Cardiology Authors: Jay H. Traverse Tags: Editorial Source Type: research

Sensitivity and specificity of different exercise oscillatory ventilation definitions to predict 2-year major adverse cardiovascular outcomes in chronic heart failure patients
This study aims to analyze the sensitivity and specificity of three EOV diagnostic definitions to predict adverse outcomes at a 2-year follow-up and to compare its EOV prevalence and relations with the patient's profile. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 24, 2022 Category: Cardiology Authors: Gustavo dos Santos Ribeiro, Lu ís Fernando Deresz, Elisabetta Salvioni, Dominique Hansen, Piergiuseppe Agostoni, Marlus Karsten Source Type: research

Association between comorbidities and left and right atrial dysfunction in patients with paroxysmal atrial fibrillation: Analysis of AF-RISK
To identify the association between comorbidities and left atrial (LA) and right atrial (RA) function in patients with paroxysmal atrial fibrillation (AF). (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 23, 2022 Category: Cardiology Authors: Manouk J.W. Van Mourik, Vicente Artola Arita, Aurore Lyon, Joost Lumens, Ruben R. De With, Joost P. van Melle, Ulrich Schotten, Sebastiaan C.A.M. Bekkers, Harry J.G.M. Crijns, Isabelle C. Van Gelder, Michiel Rienstra, Dominik K. Linz Source Type: research

HAND2-AS1: A novel therapeutic target for atherosclerosis
Dear Editor, (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 23, 2022 Category: Cardiology Authors: Guang-Gui Zeng, Heng Li, Chao-Ke Tang Tags: Letter to the Editor Source Type: research

Juvenile myocardial infarction: Sex matters
(See Fig. 1.) (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 23, 2022 Category: Cardiology Authors: Marco Bernardi, Luigi Spadafora, Giuseppe Biondi-Zoccai, Arturo Giordano Tags: Editorial Source Type: research

Breast arterial calcification and Epicardial adipose tissue volume but not density are independently associated with cardiovascular risk
Mammographically detected breast arterial calcification (BAC) has been proposed as surrogate marker for coronary artery disease (CAD) in women. Epicardial adipose tissue (EAT) and peri-coronary adipose tissue (PCAT) are inflammatory fat depots linked to atherogenesis. BAC has demonstrated association with inflammation, therefore we aimed to determine the association between BAC, EAT and PCAT. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 23, 2022 Category: Cardiology Authors: Vinay Goel, Ella Spear, William Cameron, Udit Thakur, Nushrat Sultana, Jasmine Chan, Sean Tan, Mitwa Joshi, Andrew Roberts, Yeong Chee Cheen, Hannah Youn, Damini Dey, Esther Davis, Stephen Nicholls, Adam Brown, Nitesh Nerlekar Source Type: research

Psychological factors and risk of atrial fibrillation: A meta-analysis and systematic review
Background:Multiple studies have shown that mental disorders are common risk factors for cardiovascular diseases (CVD). However, the relationship between psychological factors and atrial fibrillation (AF) incidence remains unclear. Therefore, we performed a systematic review and meta-analysis to assess the risk of AF due to psychological factors.Methods: PubMed, Embase, Web of Science, and Cochrane Library were searched from inception to January 2022. Relevant and eligible cohort studies were included. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 23, 2022 Category: Cardiology Authors: Hao Wu, Chenxing Li, Bolin Li, Tao Zheng, Kaiyue Feng, Yue Wu Tags: Review Source Type: research

CA125 a cause or an effect in heart failure?
Dear Editor, (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 23, 2022 Category: Cardiology Authors: Zhuoling LiMD, Santan LiMD Tags: Letter to the Editor Source Type: research

Untangling diffuse CAD: Light at the end of the tunnel?
A growing number of patients with diffuse coronary artery disease (CAD) are not considered candidates for revascularization, as the complexity of this condition is often an inhibitory factor for both percutaneous coronary intervention (PCI) and coronary artery bypass graft surgery (CABG). As such, these patients are frequently treated by means of optimal medical therapy (OMT). There is no general consensus at present how to define diffuse CAD; different investigators propose different criteria based on angiography, pressure ratios like fractional flow reserve (FFR), and vessel diameter (1,2). (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 21, 2022 Category: Cardiology Authors: Konstantinos Stathogiannis, William F. Fearon Tags: Editorial Source Type: research

Trends in mortality from aortic dissection analyzed from the World Health Organization mortality database from 2000 to 2017
Background:We assessed trends in aortic dissection (AD) death rates in 23 countries from 2000 to 2017.Methods: We extracted AD mortality data for countries with high usability data from the World Health Organization (WHO) Mortality Database and from the Center for Disease Control (CDC) WONDER Database for the United States of America (USA). Age Standardized Death Rates (ASDRs) per 100,000 population were computed. Trends were assessed by locally weighted scatter plot smoother (LOWESS) regression. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 21, 2022 Category: Cardiology Authors: N. Abdallah, C. Mouchati, C. Crowley, L. Hanna, R. Goodall, J.D. Salciccioli, D.C. Marshall, R.G.J. Gibbs, J. Shalhoub Source Type: research