Vasopressin antagonism for decompensated right-sided heart failure
Targeted treatment for decompensated right heart failure (RHF) with or without left heart failure is lacking. Vasopressin antagonists (vaptans) may offer an option by increasing urine output and fluid mobilization when used in acute decompensated HF without impacting blood pressure or renal function, both common complications of loop diuretics. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - August 13, 2018 Category: Cardiology Authors: Andrija Vidic, Jerrica E. Shuster, Zackary D. Goff, Anuradha Godishala, Susan M. Joseph, John T. Chibnall, Paul J. Hauptman Tags: Short communication Source Type: research

Cardiovascular risk assessment tools in non-Western populations
There is a growing burden of cardiovascular diseases, given the rising prevalence and incidence of risk factors such as an aging population, abdominal obesity, hypertension, diabetes mellitus, dyslipidaemia and metabolic syndrome. Primary prevention of cardiovascular diseases is therefore highly relevant for clinicians and government policy makers. Currently, several robust cardiovascular risk assessment tools have been devised using large datasets from Western populations. The American Heart Association (AHA)/American College of Cardiology (ACC) widened their indications for statin prescription [1], whereas the European S...
Source: International Journal of Cardiology - August 13, 2018 Category: Cardiology Authors: Gary Tse, Leonardo Roever, Martin C.S. Wong, Tong Liu Tags: Editorial Source Type: research

Cryoballoon ablation in high versus low volume centers – Does experience make a difference?
Pulmonary vein isolation (PVI) has become the widely accepted cornerstone of atrial fibrillation (AF) ablation to suppress initiation of atrial fibrillation by triggers located within the pulmonary veins [1,2]. Isolation of the pulmonary veins can be achieved by point-by-point radiofrequency (RF) ablation either fluoroscopically guided close to the ostium (segmental PVI) or by creating an ablation line at a greater distance around the ipsilateral pulmonary veins (circumferential ablation) guided by a 3D electroanatomical mapping system, the latter now being the gold standard [2,3]. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - August 13, 2018 Category: Cardiology Authors: Tillman Dahme Tags: Editorial Source Type: research

Moving beyond description to intervention to improve self-management knowledge for patients with atrial fibrillation
Remarkable progress has been made in therapies to treat atrial fibrillation (AF), but the long term success of such therapies rely on patients' engagement to adopt attitudes and behaviors that will promote optimal treatment outcomes. Patients with AF require knowledge to build skills and confidence to engage actively with their provider to make decisions about multiple treatment options for AF, prevent complications related to AF or its treatment, and manage risk factors that contribute to the progression of AF [1]. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - August 13, 2018 Category: Cardiology Authors: Pamela J. McCabe Tags: Editorial Source Type: research

Pulmonary vein potentials during cryoballoon ablation of atrial fibrillation. If you don't see them, look forward …and make a good lesion!
The progressist always looks forward, even if he does not see anything. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - August 13, 2018 Category: Cardiology Authors: Francesco De Sensi, Antonio Berruezo Tags: Editorial Source Type: research

There's a time for everything
Cardiovascular diseases show diurnal variation, with a higher incidence of adverse events in the early morning than in the evening. Traditionally, this diurnal variation has been ascribed to extrinsic (extracardiac) factors, including posture, physical exertion, food consumption, drug intake, temperature and light exposure, influencing the neuroendocrine, metabolic and prothrombotic status of a patient [1]. Among environmental conditions, also a less efficient medical response during the night has been hypothesized in the reported worst outcomes occurring early in the morning. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - August 13, 2018 Category: Cardiology Authors: Andrea Barison Tags: Editorial Source Type: research

Pulmonary hypertension due to lung diseases: Updated recommendations from the Cologne Consensus Conference 2018
The 2015 European Guidelines on Pulmonary Hypertension did not only cover pulmonary arterial hypertension (PAH) but also some aspects of pulmonary hypertension (PH) associated with chronic lung disease. The European Guidelines point out that the drugs currently used to treat patients with PAH (prostanoids, endothelin receptor antagonists, phosphodiesterase ‑5 inhibitors, sGC stimulators) have not been sufficiently investigated in other forms of PH. Therefore, the European Guidelines do not recommend the use of these drugs in patients with chronic lung disease and PH. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - August 11, 2018 Category: Cardiology Authors: Horst Olschewski, J ürgen Behr, Hinrich Bremer, Martin Claussen, Philipp Douschan, Michael Halank, Matthias Held, Marius M. Hoeper, Stephan Holt, Hans Klose, Stephan Krüger, Tobias J. Lange, Frank Reichenberger, Dirk Skowasch, Silvia Ulrich, Heinrike Wi Source Type: research

Impact of statin therapy on the immature platelet count in patients with coronary artery disease: A single centre cohort study
Statins represent a pivotal therapy among patients with coronary artery disease (CAD), providing both lipid-lowering and pleiotropic, anti-thrombotic and anti-inflammatory benefits. Immature platelet count (IPC) has been proposed as the fraction of younger and potentially more reactive platelets, therefore potentially affecting the risk of major cardiovascular ischemic events. The aim of the present study was to evaluate the impact of statin therapy on IPC in patients with CAD. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - August 10, 2018 Category: Cardiology Authors: Monica Verdoia, Matteo Nardin, Federica Negro, Roberta Rolla, Giuseppe De Luca, Novara Atherosclerosis Study Group (NAS) Source Type: research

Ethnic and sex differences in ambulance activation among hospitalized patients with acute coronary syndromes: Insights from the Alberta contemporary acute coronary syndrome patients invasive treatment strategies (COAPT) study
We examined whether ground EMS use varied by sex or ethnicity among a population-based cohort of ACS patients. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - August 10, 2018 Category: Cardiology Authors: Kevin R. Bainey, Wendimagegn Alemayehu, Arjun K. Gupta, Samantha L. Bowker, Robert C. Welsh, Padma Kaul Source Type: research

Intracellular acidosis via activation of Akt-Girdin signaling promotes post ischemic angiogenesis during hyperglycemia
The impaired angiogenesis is the major cause of diabetic delayed wound healing. The molecular insight remains unknown. Previous study has shown that high glucose (HG) activates Na+/H+ exchanger 1 (NHE1) and induces intracellular alkalinization, resulting in endothelial dysfunction. The aim of this study is to investigate whether activation of NHE1 in endothelial cells by HG damages the angiogenesis in vitro and in vivo. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - August 10, 2018 Category: Cardiology Authors: Hong-Ming Zhang, Mo-Yan Liu, Jun-Xiu Lu, Mo-Li Zhu, Qun Jin, Song Ping, Peng Li, Xu Jian, Ya-Ling Han, Shuang-Xi Wang, Xiao-Yan Li Source Type: research

Long-term outcome, survival and predictors of mortality after MitraClip therapy: Results from the German Transcatheter Mitral Valve Interventions (TRAMI) registry
MitraClip therapy is increasingly used in patients deemed inoperable to treat severe mitral regurgitation (MR), but long-tern data is scarce. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - August 10, 2018 Category: Cardiology Authors: Daniel Kalbacher, Ulrich Sch äfer, R. Stephan v. Bardeleben, Holger Eggebrecht, Horst Sievert, Georg Nickenig, Christian Butter, Andreas E. May, Raffi Bekeredjian, Taoufik Ouarrak, Karl-Heinz Kuck, Björn Plicht, Ralf Zahn, Stephan Baldus, Hüseyin Ince, Source Type: research

Long-term use of the wearable cardioverter defibrillator in patients with explanted ICD
To evaluate the effectiveness of wearable cardioverter defibrillator (WCD) use in protecting patients from sudden cardiac arrest (SCA) while they were treated in nonhospital settings until re-implantation of an Implantable cardioverter-defibrillator (ICD) was feasible. We sought to determine whether the WCD could be successfully utilized long term ( ≥1 year) after ICD extraction in patients at continued risk of SCD in which ICD re-implantation was not practical. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - August 10, 2018 Category: Cardiology Authors: Georgy Kaspar, Kumar Sanam, Gunjan Gholkar, Nicole R. Bianco, Steven Szymkiewicz, Dipak Shah Source Type: research

Temporal trends of the prevalence and incidence of atrial fibrillation and stroke among Asian patients with hypertrophic cardiomyopathy: A nationwide population-based study
Atrial fibrillation (AF) and stroke are common in hypertrophic cardiomyopathy (HCM). We aimed to determine the prevalence and incidence of AF and stroke in patients with HCM during a 10-year period. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - August 10, 2018 Category: Cardiology Authors: You-Jung Choi, Eue-Keun Choi, Kyung-Do Han, Jin-Hyung Jung, Jiesuck Park, Euijae Lee, Wonseok Choe, So-Ryoung Lee, Myung-Jin Cha, Woo-Hyun Lim, Seil Oh Source Type: research

Improved risk stratification for patients with atrial fibrillation by advancing the concept of atrial cardiomyopathy?
Although individualized consultation and treatment of patients with atrial fibrillation is part of the daily routine and current guidelines implicate comprehensive recommendations, there are still a lot of challenging clinical constellations, where optimal strategies are debatable, as exemplified in different recommendations from major guidelines. For instance, this applies to the recommendations for oral anticoagulation in case of low-risk for systemic embolism and long-term rhythm control in case of persistent or even long-standing persistent atrial fibrillation. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - August 10, 2018 Category: Cardiology Authors: Nils B ögeholz, Dirk G. Dechering, Lars Eckardt Tags: Editorial Source Type: research

Socioeconomic disadvantages in childhood and metabolic syndrome risk: A call to action?
Cardiovascular diseases are the leading cause of death in developed countries and in Europe, accounting for more than 20% of deaths [1]. Metabolic syndrome, which is defined by an aggregation of several risk factors, namely hypertension, high triglycerides, low HDL-cholesterol, glucose intolerance/diabetes and increased waist circumference, is a well-established risk factor for cardiovascular diseases and several studies and meta-analysis performed in the last decade have consistently confirmed that association, particularly in primary prevention [2 –5]. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - August 10, 2018 Category: Cardiology Authors: Ana Teresa Tim óteo Source Type: research

Validation of the MB-LATER score for prediction of late recurrence after catheter-ablation of atrial fibrillation
Reliable identification of atrial fibrillation (AF) patients more likely to be AF-free long-term post-single catheter ablation (CA) would facilitate appropriate risk communication to patients. We validated the recently proposed MB-LATER score for prediction of late recurrences of AF (LRAF) post-CA. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - August 10, 2018 Category: Cardiology Authors: Tatjana S. Potpara, Nebojsa Mujovic, Bhradeev Sivasambu, Alena Shantsila, Milan Marinkovic, Hugh Calkins, David Spragg, Gregory Y.H. Lip Source Type: research

Plasminogen activator inhibitor-1 and tissue plasminogen activator and incident AF: Data from the PREVEND study
Tissue-type plasminogen activator (TPA) and plasminogen activator inhibitor-1 (PAI-1) have been shown to be associated with increased risk for stroke, however, the association with incident atrial fibrillation (AF) is unknown. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - August 10, 2018 Category: Cardiology Authors: Bart A. Mulder, Bastiaan Geelhoed, Pim van der Harst, Henri M. Spronk, Isabelle C. Van Gelder, Folkert W. Asselbergs, Michiel Rienstra Tags: Short communication Source Type: research

Evolving insights into the role of local shear stress in late stent failure from neoatherosclerosis formation and plaque destabilization
The process of neoatherosclerosis formation in stented portions of the coronary arteries is central to an understanding of the natural history of stent outcomes, both in the short- and long-term. Early studies demonstrated that the short-term tissue response to stent implantation was related in part to the local hemodynamic microenvironment, i.e., endothelial shear stress (ESS), such that low ESS led to increased neointimal thickness in bare-metal stents (BMS) compared to first generation drug eluting stents (DES), within which the anti-proliferative agent suppressed the neointimal hyperplasia response. (Source: Internatio...
Source: International Journal of Cardiology - August 10, 2018 Category: Cardiology Authors: Peter H. Stone, Ahmet Umit Coskun, Kevin J. Croce Tags: Editorial Source Type: research

Advanced interatrial block predicts atrial fibrillation recurrence across different populations: Learning Bay és syndrome
Interatrial block (IAB), which occurs due to a conduction delay between the right and left atria, is a significant predictor for both new onset and recurrent atrial fibrillation (AF) [1]. The substrate for IAB is electrical atrial remodeling due to fibrosis, inducing interatrial dyssynchrony. The electromechanical dysfunction of the left atrium (LA) induces a pathophysiological chain of events: abnormal activation of the LA, increased LA pressure, LA dilatation, endothelial dysfunction, atrial fibrosis, and ultimately, thrombogenic cascade. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - August 10, 2018 Category: Cardiology Authors: Adrian Baranchuk, Cynthia Yeung Tags: Editorial Source Type: research

Impact of vascular access on the development of contrast induced nephropathy in patients undergoing coronary angiography and/or percutaneous coronary intervention
Contrast induced nephropathy (CIN) is a common complication of procedures that foresee the use of contrast media. Several risk factors have been identified as independent predictors of CIN, but, to date, no definitive data are available about the association between the angiographic approach and its development. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - August 9, 2018 Category: Cardiology Authors: Lucia Barbieri, Monica Verdoia, Harry Suryapranata, Giuseppe De Luca, on behalf of the Novara Atherosclerosis Study Group (NAS) Source Type: research

Fractional flow reserve in acute coronary syndromes and in stable ischemic heart disease: Clinical implications
Fractional Flow Reserve (FFR) in Stable Ischemic Heart Disease (SIHD) is universally accepted, while in Acute Coronary Syndromes (ACS) is less established.Aims of this retrospective study were: to compare in patients undergoing FFR assessment the prognostic impact of ACS vs SIHD, to evaluate the clinical relevance of the modality of utilization and timing of FFR assessment and to assess the different outcomes associated with an FFR> or ≤0.80. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - August 9, 2018 Category: Cardiology Authors: Antonio Maria Leone, Pio Cialdella, Francesca Lassandro Pepe, Eloisa Basile, Giuseppe Zimbardo, Manfredi Arioti, Giovanna Ciriello, Domenico D'Amario, Antonino Buffon, Francesco Burzotta, Italo Porto, Cristina Aurigemma, Giampaolo Niccoli, Antonio G. Rebu Source Type: research

Transcatheter aortic valve implantation in patients younger than 75  years: Guidelines-based patients selection and clinical outcome
Patients treated by transcatheter aortic valve implantation (TAVI) in all major recent trials are still mostly octogenarians. Aim of this study is to analyze the risk profile and outcome of TAVI patients (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - August 9, 2018 Category: Cardiology Authors: Chiara Fraccaro, Luca Testa, Alessandro Schiavo, Nedy Brambilla, Massimo Napodano, Danila Azzolina, Francesco Bedogni, Giuseppe Tarantini Source Type: research

Dual versus triple therapy in patients on oral anticoagulants and undergoing coronary stent implantation: A systematic review and meta-analysis
There is contrasting evidence regarding the optimal antithrombotic regimen after percutaneous coronary stent implantation in patients on oral anticoagulants. A systematic review and meta-analysis was performed to explore the comparative efficacy and safety of dual (an antiplatelet plus an oral anticoagulant) versus triple therapy (dual antiplatelet therapy plus an oral anticoagulant). (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - August 9, 2018 Category: Cardiology Authors: Federico Fortuni, Marco Ferlini, Sergio Leonardi, Filippo Angelini, Gabriele Crimi, Alberto Somaschini, Stefano Cornara, Antonella Potenza, Stefano De Servi, Luigi Oltrona Visconti, Gaetano Maria De Ferrari Source Type: research

A potential and novel therapeutic approach to ischemic heart failure: Algisyl-LVR
We have read with great interest of the recently published article entitled “Efficacy of intramyocardial injection of Algisyl-LVR for the treatment of ischemic heart failure (HF) in swine” by Choy et al. [1]. Their results revealed that Algisyl-LVR is an effective strategy that serves as a micro-left ventricular (LV) assist device to reduce LV wall stress and hence prev ent or reverse maladaptive cardiac remodeling caused by HF. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - August 9, 2018 Category: Cardiology Authors: Suiyang Tong, Liangliang Zhang, Jacob Joseph, Xuejun Jiang Tags: Letter to the Editor Source Type: research

Ventricular arrhythmias and myocardial inflammation: Long-term follow-up of patients with suspected myocarditis
Inflammatory heart disease is known to be associated with ventricular arrhythmias (VA) and impaired ventricular function at presentation or during follow-up. We aimed to investigate the need for implanted cardioverter defibrillator (ICD) due to ventricular dysfunction and occurrence of VA during long-term follow-up in patients admitted with suspected myocarditis. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - August 8, 2018 Category: Cardiology Authors: Valerie Pavlicek, Ingrid Kindermann, Jan Wintrich, Felix Mahfoud, Karin Klingel, Michael B öhm, Christian Ukena Source Type: research

The risk-treatment paradox in non-ST-elevation myocardial infarction patients according to their estimated GRACE risk
The purpose was to describe the treatment and outcomes of non-ST-elevation myocardial infarction (NSTEMI) in Estonia according to patients' estimated mortality risk by the Global Registry of Acute Coronary Events (GRACE) score and investigate if inequalities in treatment had an impact on prognosis. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - August 8, 2018 Category: Cardiology Authors: Aet Saar, Toomas Marandi, Tiia Ainla, Krista Fischer, Mai Bl öndal, Jaan Eha Source Type: research

Risk factors of pericardial effusion in native valve infective endocarditis and its influence on outcome: A multicenter prospective cohort study
Pericardial effusion is a frequent finding in the setting of infective endocarditis. Limited data exists on clinical characteristics and outcomes in this group of patients. We aimed to determine the associated factors, clinical characteristics, and outcomes of patients who had pericardial effusion and native valve infective endocarditis. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - August 7, 2018 Category: Cardiology Authors: Ander Regueiro, Carlos Falces, Juan M. Peric ás, Patricia Muñoz, Manuel Martínez Sellés, Maricela Valerio, Dolores Sousa Regueiro, Laura Castelo, Arístides de Alarcón, Manuel Cobo Belaustegui, Miguel Angel Goenaga, Carmen Hidalgo-Tenorio, Francisco Source Type: research

Identification of suitable patients for ICD therapy
Despite the results of randomized trials performed>10  years ago showing that prophylactic implantation of cardioverter-defibrillator (ICD) for patients with impaired left ventricular ejection fraction (LVEF) improves survival in both ischemic and non-ischemic cardiomyopathy [1,2], prophylactic ICD therapy has been challenged in the current era. It h as been proposed that ICD candidates today exhibit lower rates of fatal arrhythmias and have better outcome without an ICD than patients included in the seminal trials reported>10  years ago, most probably due to improvements in pharmacological and invasive non-ICD t...
Source: International Journal of Cardiology - August 7, 2018 Category: Cardiology Authors: Heikki Huikuri, Alfred E. Buxton Tags: Editorial Source Type: research

Statin therapy contributes to plaque-stability by increasing the presence of calcification of plaque
We read with great interest the article by Mujaj B and colleagues [1]. Authors concluded that current statin treatment, in particular long-term usage or high dosage of statin, played a protective role in plaque stability. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - August 7, 2018 Category: Cardiology Authors: Xiao Du, Shilan Zhang, Ling Liu Tags: Letter to the Editor Source Type: research

Reply to “PCSK9: Entering a new era of cardiovascular risk prediction”
We would thank Dr. Schindler and Leucker for their valuable comments [1] on our recent publication in International Journal of Cardiology [2]. We have particularly appreciated their focus on the main innovative aspect of our research study: the potential pro-atherosclerotic activity of proprotein convertase subtilisin/kexin type 9 (PCSK9), which are independent of low density lipoprotein (LDL) levels. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - August 7, 2018 Category: Cardiology Authors: Luca Liberale, Aldo Bonaventura, Federico Carbone, Fabrizio Montecucco Tags: Letter to the Editor Source Type: research

Circulating long noncoding RNA DKFZP434I0714 predicts adverse cardiovascular outcomes in patients with end-stage renal disease
Cardiovascular (CV) diseases are major causes of mortality in uremic patients. Conventional risk factors fail to identify uremic patients with increased propensity for adverse CV outcomes. We aimed to test the hypothesis that circulating long noncoding RNAs (lncRNAs) could be a prognostic marker to predict adverse CV outcomes in uremic patients. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - August 6, 2018 Category: Cardiology Authors: Chun-Fu Lai, Yen-Ting Chen, Jian Gu, Jeanne M. Nerbonne, Chin-Hsien Lin, Kai-Chien Yang Source Type: research

Effect of sacubitril/valsartan on cardiac filling pressures in patients with left ventricular systolic dysfunction
Sacubitril/valsartan is the newest neurohormonal agent approved for therapy in patients with heart failure with reduced ejection fraction (HFrEF). Little is known about its acute and incremental hemodynamic effects. We aimed to evaluate the change in hemodynamic profiles measured using an implanted monitoring device in HFrEF patients initiated on sacubitril/valsartan therapy. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - August 6, 2018 Category: Cardiology Authors: Zubair Khan, Gunjan Gholkar, Sunit Tolia, Herman Kado, Marcel Zughaib Source Type: research

Dose-dependent efficacy of β-blocker in patients with chronic heart failure and atrial fibrillation
The usefulness of β-blockers in heart failure (HF) patients with permanent atrial fibrillation (AF) has been questioned. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - August 6, 2018 Category: Cardiology Authors: Jeness Campodonico, Massimo Piepoli, Francesco Clemenza, Alice Bonomi, Stefania Paolillo, Elisabetta Salvioni, Ugo Corr à, Simone Binno, Fabrizio Veglia, Rocco Lagioia, Gianfranco Sinagra, Gaia Cattadori, Angela B. Scardovi, Marco Metra, Michele Senni, D Source Type: research

Clinical and prognostic impact of chronotropic incompetence in patients with hypertrophic cardiomyopathy
A blunted heart rate (HR) response is associated with an impaired peak oxygen uptake (pVO2), a powerful outcome predictor in hypertrophic cardiomyopathy (HCM). The present multicenter study sought to determine the prognostic role for exercise-induced HR response in HCM. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - August 6, 2018 Category: Cardiology Authors: Damiano Magri, Piergiuseppe Agostoni, Gianfranco Sinagra, Federica Re, Michele Correale, Giuseppe Limongelli, Elisabetta Zachara, Vittoria Mastromarino, Caterina Santolamazza, Matteo Casenghi, Giuseppe Pacileo, Fabio Valente, Marco Morosin, Beatrice Musum Source Type: research

Cardiovascular risk factors in adults with congenital heart defects — Recognised but not treated? An analysis of the German National Register for Congenital Heart Defects
As adult congenital heart disease (ACHD) patients are aging, a high prevalence of cardiovascular risk factors is encountered similar to the general population. Currently, data regarding the primary and secondary prevention of acquired cardiovascular disease in ACHD is lacking. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - August 6, 2018 Category: Cardiology Authors: Ulrike M.M. Bauer, Marc-Andr é Körten, Gerhard-Paul Diller, Paul Helm, Helmut Baumgartner, Peter Ewert, Oktay Tutarel Source Type: research

Association of body mass index and diastolic function in metabolically healthy obese with preserved ejection fraction
Small scale cohorts demonstrated an association between body mass index (BMI) and diastolic function in a metabolically healthy population. We aimed to characterize the relation between BMI and diastolic function in a relatively large cohort of metabolically healthy obese with preserved ejection fraction. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - August 6, 2018 Category: Cardiology Authors: Zach Rozenbaum, Yan Topilsky, Shafik Khoury, David Pereg, Michal Laufer-Perl Source Type: research

Does second-generation cryoballoon ablation using the current single short freeze strategy produce pulmonary vein stenosis?
This study aimed to evaluate the incidence of PV stenosis after CB2-PVI with the current standard strategy. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - August 6, 2018 Category: Cardiology Authors: Shinsuke Miyazaki, Takatsugu Kajiyama, Masahiro Hada, Hiroaki Nakamura, Hitoshi Hachiya, Hiroshi Tada, Kenzo Hirao, Yoshito Iesaka Source Type: research

Automatic annular sizing - What's in a millimeter?
Transcatheter aortic valve replacement (TAVR) has largely replaced surgery in elderly and other high-risk patients with severe aortic stenosis and is also widely utilized in moderate-risk patients. Safety and outcome following TAVR have significantly improved with time, largely due to improved prosthetic design [1] and due to more accurate 3-dimensional pre-procedural planning using multidetector computed tomography (MDCT) [2,3]. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - August 6, 2018 Category: Cardiology Authors: Jonathan Lessick, Doron Aronson Tags: Editorial Source Type: research

Heart rate variability as a marker of healthy ageing
With population ageing a significant concern, modifiable factors contributing to healthy ageing must be identified. Autonomic responding reflected by heart rate variability (HRV) has well-established links to general health and wellbeing in younger populations; but has yet to be explored in older individuals. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - August 3, 2018 Category: Cardiology Authors: Jason Por How Tan, Jessica Elise Beilharz, Ut é Vollmer-Conna, Erin Cvejic Tags: Short communication Source Type: research

Performing diagnostic coronary angiography to evaluate high-risk cardiac donors: A French nationwide cohort study
Allograft shortage might be overcome by the use of hearts from expanded-criteria donors (ECD) but their estimated high-risk of coronary artery disease (CAD) results in a limited utilization of these hearts for transplantation. We aimed to determine if performing coronary angiography (CA) in ECD enhances cardiac procurement and to develop a predictive model estimating their probability of absence of CAD. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - August 3, 2018 Category: Cardiology Authors: Fabrice Ivanes, Christelle Cantrelle, Thibaud Genet, Claude Le Feuvre, Camille Legeai, Carine Jasseron, Isabelle Pipien, Eric Epailly, Olivier Bastien, Denis Angoulvant, Richard Dorent Source Type: research

Comparison of long-term clinical outcomes between revascularization versus medical treatment in patients with silent myocardial ischemia
There have been limited and conflicting results regarding the prognostic impact of revascularization treatment on the long-term clinical outcomes of silent ischemia. The current study aimed to determine whether revascularization treatment compared with medical treatment (MT) alone reduces long-term risk of cardiac death of asymptomatic patients with objective evidence of inducible myocardial ischemia. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - August 3, 2018 Category: Cardiology Authors: Ki Hong Choi, Joo Myung Lee, Il Park, Jihoon Kim, Tae-Min Rhee, Doyeon Hwang, Jonghanne Park, Taek Kyu Park, Jeong Hoon Yang, Young Bin Song, Joo-Yong Hahn, Dong Seop Jeong, Yang Hyun Cho, Wook Sung Kim, Kiick Sung, Mi Ja Jang, Ji Dong Sung, Jin-Ho Choi, Source Type: research

Utility of temporal profiles of new cardio-renal and pulmonary candidate biomarkers in chronic heart failure
Our aim was to explore potential use of temporal profiles of seven emerging cardio-renal and two pulmonary candidate biomarkers for predicting future adverse clinical outcome in stable patients with chronic heart failure (CHF). (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - August 3, 2018 Category: Cardiology Authors: Milos Brankovic, K. Martijn Akkerhuis, Henk Mouthaan, Alina Constantinescu, Kadir Caliskan, Jan van Ramshorst, Tjeerd Germans, Victor Umans, Isabella Kardys Source Type: research

Prediction of myocardial infarction, stroke and cardiovascular mortality with urinary biomarkers of oxidative stress: Results from a large cohort study
Oxidative stress contributes to endothelial dysfunction and is involved in the pathogenesis of cardiovascular diseases (CVD). However, large population-based cohort studies are sparse and biomarkers of oxidative stress have not been evaluated for CVD risk prediction so far. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - August 3, 2018 Category: Cardiology Authors: Yang Xuan, X īn Gào, Bernd Holleczek, Hermann Brenner, Ben Schöttker Source Type: research

Reducing late maternal death due to cardiovascular disease - A pragmatic pilot study
Late maternal mortality (up-to 1-year postpartum) is poorly reported globally and is commonly due to cardiovascular disease (CVD). We investigated targeted interventions aiming at reducing peripartum heart failure admission and late maternal death. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - August 3, 2018 Category: Cardiology Authors: Karen Sliwa, Feriel Azibani, Johann Baard, Ayesha Osman, Liesl Z ühlke, Anthony Lachmann, Elena Libhaber, Ashley Chin, Mpiko Ntsekhe, Priya Soma-Pillay, Mark R. Johnson, Jolien Roos-Hesselink, John Anthony Source Type: research

Pulse pressure for selecting the optimal cardiac strategy in patients with type 2 diabetes and coronary artery disease
This study aimed to assess the association between the cardiac treatment strategies and risk of major adverse cardiovascular events (MACE) in patients with type 2 diabetes and coronary artery disease (CAD), based on low or high levels of pulse pressure. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - August 2, 2018 Category: Cardiology Authors: Tetsuro Tsujimoto, Hiroshi Kajio Source Type: research

Editorial: Automating subcutaneous ICD screening and future sensing refinements
The avoidance of transvenous leads is the key innovation of the Subcutaneous ICD (S-ICD) carrying the benefits of preventing longterm vascular complications& lead issues requiring potentially hazardous interventions especially extraction. However, this brings the challenge of ensuring optimal sensing of ventricular arrhythmias in the absence of intracardiac electrograms. By utilising the 3 sensing vectors to differentiate the R wave from T wave, very effective sensing is possible avoiding unnecessary shocks for SVT outperforming transvenous device algorithms for the latter [1]. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - August 2, 2018 Category: Cardiology Authors: P.D. Lambiase Tags: Editorial Source Type: research

Ramipril and left ventricular diastolic function in stable patients with pulmonary regurgitation after repair of tetralogy of Fallot
Measures of left ventricular (LV) systolic and diastolic function are known predictors of mortality after repair of tetralogy of Fallot. We aimed to characterise LV reverse remodelling achievable with ramipril therapy. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - August 1, 2018 Category: Cardiology Authors: Sylvia Krupickova, Wei Li, Mun Hong Cheang, Michael L. Rigby, Anselm Uebing, Periklis Davlouros, Konstantinos Dimopoulos, Giovanni Di Salvo, Alain Fraisse, Lorna Swan, Rafael Alonso-Gonzalez, Aleksander Kempny, Dudley J. Pennell, Roxy Senior, Michael A. G Source Type: research

Initial single centre experience with the novel Rhythmia © high density mapping system in an all comer collective of 400 electrophysiological patients
A novel, automatically annotating ultra-high density mapping system (Rhythmia ©, Boston Scientific) collects a high number and quality of electrograms (EGMs). So far, data on general use in the electrophysiological laboratory are sparse. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - August 1, 2018 Category: Cardiology Authors: Korbinian Lackermair, Stefanie Kellner, Antonia Kellnar, Lisa M. Riesinger, Reza Wakili, Moritz F. Sinner, Konstantinos D. Rizas, Stephanie Fichtner, Heidi L. Estner Source Type: research

Admission heart rate and in-hospital course of patients with Takotsubo syndrome
In-hospital course of patients with Takotsubo syndrome (TS) is quite heterogeneous and life-threatening complications are not uncommon in the acute phase. The role of heart rate (HR) as a predictor of prognosis has not been sufficiently investigated in this setting. The study aims to assess the impact of HR at presentation on in-hospital course of patients with TS. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - August 1, 2018 Category: Cardiology Authors: Luca Arcari, Luca Rosario Limite, Luca Cacciotti, Matteo Sclafani, Domitilla Russo, Ilaria Passaseo, Giuseppe Marazzi, Gerardo Ansalone, Massimo Volpe, Camillo Autore, Maria Beatrice Musumeci Source Type: research

The CARVIVA HF trial- Is the devil in the detail?
Volterrani and colleagues [1] published a prospective, randomised, blinded study in patients with heart failure (HF). They studied patients exercise capacity at baseline and after carvedilol monotherapy, ivabradine monotherapy or dual therapy. They used the 6-min walk test (6MWT) and VO2 peak as their primary end-points along with modalities such as echo, NYHA classification and quality of life. They have concluded that ivabradine and dual therapy improve exercise capacity and quality of life in HF patients. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - August 1, 2018 Category: Cardiology Authors: Murray Richard Williams Tags: Letter to the editor Source Type: research