Short term outcomes of Impella in cardiogenic shock: A review and meta-analysis of observational studies
Introduction: The clinical impact of invasive hemodynamic support with Impella in patients with cardiogenic shock (CS) remains to be defined.Methods: Only studies including patients treated with Impella in CS were selected. The primary endpoint was short term mortality, while secondary endpoints were major vascular complications and major bleeding.Results: 17 studies and 3933 patients were included in the analysis. Median age was 61.9 (IQR 59.2 –63.5) years, CS was mainly related to acute coronary syndrome (ACS): 79.6% (IQR 75.1–79.6). (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - September 21, 2020 Category: Cardiology Authors: Iannaccone Mario, Stefano Albani, Francesco Giannini, Salvatore Colangelo, Giacomo G. Boccuzzi, Garbo Roberto, Emmanouil S. Brilakis, D ’ascenzo Fabrizio, Gaetano Maria de Ferrari, Antonio Colombo Source Type: research

Rapid reduction in plaque inflammation by sonodynamic therapy in patients with symptomatic femoropopliteal peripheral artery disease: A randomized controlled trial
Inflammation is actively involved in the clinical manifestation of peripheral artery disease (PAD). Sonodynamic therapy (SDT), a novel non-invasive, plaque-based, macrophage-targeted anti-inflammatory regimen for atherosclerosis has the potential to improve walking performance by reducing plaque inflammation. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - September 20, 2020 Category: Cardiology Authors: Yongxing Jiang, Jingxue Fan, Yong Li, Guodong Wu, Yuanqi Wang, Jiemei Yang, Mengjiao Wang, Zhengyu Cao, Qiannan Li, Hui Wang, Zhengyan Zhang, Yu Wang, Bicheng Li, Fengyu Sun, Haiyu Zhang, Zhiguo Zhang, Kang Li, Ye Tian Source Type: research

Impact of instantaneous wave-free ratio on graft failure after coronary artery bypass graft surgery
We aimed to assess an impact of instantaneous wave-free ratio (iFR) on a graft failure after coronary artery bypass grafting (CABG). (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - September 20, 2020 Category: Cardiology Authors: Teruaki Wada, Yasutsugu Shiono, Takashi Kubo, Kentaro Honda, Masahiro Takahata, Kunihiro Shimamura, Mitsuru Yuzaki, Takashi Tanimoto, Yoshiki Matsuo, Atsushi Tanaka, Takeshi Hozumi, Yoshiharu Nishimura, Takashi Akasaka Source Type: research

Association between time of out-of-hospital cardiac arrest and survival: Examination of the all-Japan Utstein registry and comparison with the 2005 and 2010 international resuscitation guidelines
We examined whether the one-month survival rate for out-of-hospital cardiac arrests differed depending on whether the cardiac arrest occurred during the day or night. Further, we examined whether this rate differed when comparing the period succeeding the 2005 International Resuscitation Guidelines (2006 –2010) with that following the 2010 guidelines (2011–2015). (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - September 19, 2020 Category: Cardiology Authors: Katsuhito Kato, Toshiaki Otsuka, Yoshihiko Seino, Yoshio Tahara, Naohiro Yonemoto, Hiroshi Nonogi, Ken Nagao, Takanori Ikeda, Naoki Sato, Hiroyuki Tsutsui, Japanese Circulation Society with Resuscitation Science Study (JCS-ReSS) Group Source Type: research

Assessing QT interval in COVID-19 patients: Safety of Hydroxychloroquine-azithromycin combination regimen
Hydroxychloroquine (HCQ) and azithromycin (AZT) have been proposed for COVID-19 treatment. Data available in the literature reported a potential increased risk of fatal arrhythmias under these therapies. The aim of this study was to assess the effects of these drugs on QT interval and outcome in a COVID-19 population. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - September 18, 2020 Category: Cardiology Authors: Andrea Bernardini, Giuseppe Ciconte, Gabriele Negro, Roberto Rondine, Valerio Mecarocci, Tommaso Viva, Francesca Santini, Carlo de Innocentiis, Luigi Giannelli, Ewa Witkowska, Emanuela Teresina Locati, Serenella Castelvecchio, Massimiliano Marrocco-Trisch Source Type: research

MicroRNA-3614 regulates inflammatory response via targeting TRAF6-mediated MAPKs and NF- κB signaling in the epicardial adipose tissue with coronary artery disease
The inflammatory status of epicardial adipose tissue (EAT) is one of the factors leading to the development of related diseases such as coronary artery disease (CAD). The thickness of CAD EAT increases and is accompanied with increased macrophage infiltration and heightened inflammatory responses. However, microRNAs (miRNAs) regulating the inflammatory responses of macrophages in CAD EAT remain unclear. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - September 17, 2020 Category: Cardiology Authors: Wenhua Huang, Xinggang Wu, Yajun Xue, Yijun Zhou, Hui Xiang, Wenkai Yang, Yutao Wei Source Type: research

Outcome of patients on heart transplant list treated with a continuous-flow left ventricular assist device: Insights from the TRans-Atlantic registry on VAd and TrAnsplant (TRAViATA)
Geographic variations in management and outcomes of individuals supported by continuous-flow left ventricular assist devices (CF-LVAD) between the United States (US) and Europe (EU) is largely unknown. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - September 17, 2020 Category: Cardiology Authors: Enrico Ammirati, Michela Brambatti, Oscar Ö. Braun, Palak Shah, Manlio Cipriani, Quan M. Bui, Jesse Veenis, Euyhyun Lee, Ronghui Xu, Kimberly N. Hong, Caroline M. Van de Heyning, Enrico Perna, Philippe Timmermans, Maja Cikes, Jasper J. Brugts, Giacomo Ve Source Type: research

Percutaneous coronary intervention underperforms in Takayasu Arteritis
“Percutaneous coronary intervention underperforms in Takayasu Arteritis” (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - September 16, 2020 Category: Cardiology Authors: Sourabh Agstam, Ankur Gupta Tags: Letter to the Editor Source Type: research

The optimal transferrin saturation level in patients with heart failure and anemia
We have read with great interest the article of Ambrosy et al., demonstrating transferrin saturation (TSAT) is an independent risk factor for heart failure (HF) hospitalizations and all-cause mortality in patients with HF and anemia [1]. We have two concerns that would improve the implication of their findings. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - September 16, 2020 Category: Cardiology Authors: Toshihide Izumida, Teruhiko Imamura Tags: Letter to the Editor Source Type: research

Letter to the editor: Inspiratory muscle training did not improve exercise capacity and lung function in adult patients with Fontan circulation: A randomized controlled trial
We read with great interest the article by Fritz et al. [1], which revealed the efficacy of 6  months of daily home-based inspiratory muscle training (IMT) on exercise capacity and lung function in adult patients with Fontan circulation. However, we would like to know more about the results of this report. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - September 16, 2020 Category: Cardiology Authors: Kosuke Sasaki, Yoshimitsu Takahashi, Takeo Nakayama Tags: Letter to the editor Source Type: research

Editorial Board
(Source: International Journal of Cardiology)
Source: International Journal of Cardiology - September 16, 2020 Category: Cardiology Source Type: research

MicroRNA-26b might be a novel therapeutic target in the treatment of myocardial infarction
Dear Editor, (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - September 16, 2020 Category: Cardiology Authors: Fu Zhu, Yanhong Liu, Keqing Tang Tags: Letter to the Editor Source Type: research

High prevalence of subtle systolic and diastolic dysfunction in genotype-positive phenotype-negative relatives of dilated cardiomyopathy patients
The early diagnosis of genetically determined dilated cardiomyopathy (DCM) could improve the prognosis in mutation carriers. Left ventricular global longitudinal strain (LV GLS) and peak left atrial longitudinal strain (PALS) are promising techniques for the detection of subtle systolic and diastolic dysfunction. We sought to evaluate the prevalence of subtle systolic and diastolic dysfunction by LV GLS and PALS in a cohort of genotype-positive phenotype-negative (GPFN) DCM relatives. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - September 16, 2020 Category: Cardiology Authors: Alessia Paldino, Giulia De Angelis, Matteo Dal Ferro, Giorgio Faganello, Aldostefano Porcari, Giulia Barbati, Renata Korcova, Piero Gentile, Jessica Artico, Antonio Cannat à, Marta Gigli, Bruno Pinamonti, Marco Merlo, Gianfranco Sinagra Source Type: research

Clinical impact of red blood cell transfusion on adverse clinical events in acute heart failure patients with anemia
Anemia has been recognized an important comorbidity in patients with acute heart failure (AHF) and is associated with adverse clinical events. However, the clinical impact of red blood cell (RBC) transfusion in such patients is unclear. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - September 15, 2020 Category: Cardiology Authors: Satoshi Higuchi, Noritaka Hata, Shigeki Shibata, Kazukuni Hirabuki, Tomoya Suda, Kazuna Honda, Hiroshi Hasegawa, Takeaki Matsuda Source Type: research

Are all left bundle branch blocks the same? Myocardial mechanical implications by cardiovascular magnetic resonance
Aims: Left bundle branch block (LBBB) is usually associated with structural myocardial diseases progressively leading to left ventricular (LV) dysfunction. We sought to determine the mechanical implications of LBBB (as defined based on Strauss' criteria) by Cardiovascular Magnetic Resonance (CMR). (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - September 14, 2020 Category: Cardiology Authors: A. Baritussio, G. Biglino, S. Moharem-Elgamal, E. De Garate, I. Harries, A. Ghosh Dastidar, E.G. Milano, C. Bucciarelli-Ducci Source Type: research

Cardiac implantable device outcomes and lead survival in adult congenital heart disease
Long-term outcomes of cardiac implantable electronic devices (CIEDs) are ill-defined in adult congenital heart disease (ACHD). (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - September 14, 2020 Category: Cardiology Authors: Hilary C. Bowman, Kevin M. Shannon, Reshma Biniwale, Jeremy P. Moore Source Type: research

Somatic growth, valve and artery size, and cardiac function; the relevance of growth parameters for patients born with a single ventricle.
The Fontan procedure has provided a lifeline for many patients born with a single ventricle circulation. Patients still experience a high incidence of morbidity and mortality compared to their biventricular counterparts [1]. Many factors remain under investigation regarding their contribution to poor clinical outcome. The work of Granegger et al. [2] presents a wealth of data on growth and many cardiac parameters. It can therefore be of great use to illustrate the impact of a single ventricle circulation on physical growth and, conversely, the impact of nutritional status and body mass on patient outcome. (Source: Internat...
Source: International Journal of Cardiology - September 14, 2020 Category: Cardiology Authors: Yves d'UdekemMD, Emma PayneBBMed Tags: Editorial Source Type: research

Regional variation in patients and outcomes in the GLOBAL LEADERS trial
Despite the overall neutral results of the GLOBAL-LEADERS trial, results from a prespecified subgroup analysis showed that patients from Western Europe had a significantly lower rate of the primary endpoint when treated with ticagrelor monotherapy. Therefore, we aimed to examine the regional disparities in patients' baseline characteristics and their response to ticagrelor monotherapy. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - September 14, 2020 Category: Cardiology Authors: Chao Gao, Kuniaki Takahashi, Scot Garg, Hironori Hara, Rutao Wang, Hideyuki Kawashima, Masafumi Ono, Gilles Montalescot, Michael Haude, Ton Slagboom, Pascal Vranckx, Marco Valgimigli, Stephan Windecker, Christian Hamm, Philippe Gabriel Steg, Robert Storey Source Type: research

Diagnostic utility of right atrial reservoir strain to identify elevated right atrial pressure in heart failure
This study aimed to evaluate the utility of right atrial reservoir strain (RASr) assessed by speckle-tracking echocardiography to identify elevated RAP in HF and compare diagnostic performance with estimated RAP employing inferior vena cava size and collapsibility (RAPIVC), in addition to RA area. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - September 14, 2020 Category: Cardiology Authors: Nabiliah Tafannum Miah, Ulrika Ljung Fax én, Lars H. Lund, Ashwin Venkateshvaran Source Type: research

Heart transplantation in adult congenital heart disease: Importance of timely referral
In the growing population of adults with congenital heart disease (CHD) heart failure (HF) remains the leading cause of premature death [1]. Pharmacological therapy and assist devices are used with limited success and heart transplantation represents the final option for a select number of patients with end-stage CHD. However, transplant programs in this unique population are challenged due to specific considerations such as previous operations and sternotomies, human leucocyte antigen (HLA) sensitisation, complex cardiac anatomies and skeletal abnormalities, pulmonary vascular disease, reasons to require transplantation i...
Source: International Journal of Cardiology - September 14, 2020 Category: Cardiology Authors: Margarita Brida Tags: Editorial Source Type: research

Two arteries better than one? The jury is still out
The meta-analysis by Saraiva et al. [1] adds more weight to the body of circumstantial evidence in the literature that was built up over the last two decades. The addition of a second arterial conduit is associated with better long-term survival than single arterial grafting [2,3] —longer patency of arterial grafts as compared to veins likely drives these outcomes. This becomes evident in the long-term follow-up. The angiographic patency of the left internal mammary artery is>95% at 15  years, and that of the right internal mammary artery>90% at ten years [4]. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - September 14, 2020 Category: Cardiology Authors: Daniel P. Fudulu, Gianni D. Angelini Tags: Editorial Source Type: research

The dynamic of ECG in Takotsubo Syndrome and myocardial infarction: the long quest for an intriguing non-invasive differential diagnosis between ischemic syndromes
Takotsubo syndrome (TTS), from its first description [1], shares many clinical features with acute coronary syndromes (ACS): TTS is defined as a heterogenous stress triggered syndrome characterized by transient wall motion abnormalities of the left ventricle without significant epicardial coronary artery disease and dynamic ST segment and/or T wave abnormalities, with only modest elevation of cardiac biomarkers disproportionate to the extent of wall motion/ECG abnormalities [2,3]. TTS accounts for about 2% of all patients presenting with symptoms of ACS [4]. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - September 13, 2020 Category: Cardiology Authors: Ancona Francesco Tags: Editorial Source Type: research

Prevalence and clinical significance of totally occluded infarct-related arteries in patients with non-ST-segment elevation acute coronary syndromes
Background Seemingly conflicting findings exist regarding the prognostic impact of totally occluded infarct-related arteries (oIRA) in non-ST elevation acute coronary syndromes (NSTE-ACS).Methods Retrospective analysis of prospective multicenter registry data comprising a single-center NSTE-ACS cohort, aimed at assessing the impact of occluded (TIMI flow 0/1) versus patent culprit vessels (pIRA, TIMI flow 2/3) on the composite endpoint of all-cause death and cardiogenic shock events at 30  days.Results Of 568 patients, 183 (32.5%) had oIRA. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - September 12, 2020 Category: Cardiology Authors: Almendro-Delia Manuel, Seoane Garc ía Tania, Villar Calle Pablo, García González Néstor, Lorenzo López Beatriz, Cortés Francisco Javier, García del Río Manuel, Ruiz García María del Pilar, J. Hidalgo Urbano Rafael, C. García-Rubira Juan Source Type: research

Timing of cardiovascular magnetic resonance in clinical trials evaluating cardioprotective therapies to reduce infarct size
Although the short- and long-term clinical outcomes of patients with ST-segment elevation myocardial infarction (STEMI) has improved substantially over the last 2 decades the risk of future cardiovascular events, in particular heart failure, remains high [1]. The most important determinant of long-term clinical outcomes after STEMI is infarct size (IS). In a recent meta-analysis, IS measured within 1  month after primary percutaneous intervention (pPCI) was strongly associated with all-cause mortality and hospitalization for heart failure within 1 year [2]. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - September 12, 2020 Category: Cardiology Authors: Joseph B. Selvanayagam, Rajiv Ananthakrishna, Cheerag Shirodaria, Keith Channon Tags: Commentary Source Type: research

Traumatic brain injury donation is not associated with poorer outcomes following orthotopic heart transplantation
Great concern has been expressed within the transplant community regarding the utilisation of hearts from donors following traumatic brain death (TBD). Brain death initiates pathological endothelial activation, up-regulation of cell adhesion molecules, and release of pro-inflammatory cytokines and other mediators through complex neuro-hormonal pathways. These processes manifest with haemodynamic disturbance, myocardial impairment from diffuse endothelial injury, calcium overload and impaired coronary blood flow, and a reduction in the cardioprotective effects of ischaemic pre-conditioning, which ultimately compromise graft...
Source: International Journal of Cardiology - September 12, 2020 Category: Cardiology Authors: Metesh Acharya, Aron-Frederik Popov Tags: Editorial Source Type: research

Association of Body Mass Index with Endothelial Function in Asian Men.
Background: The association of body weight with cardiovascular events is still controversial. We evaluated the relationship between body mass index (BMI) and endothelial function.Methods: We measured flow-mediated vasodilation (FMD) and BMI in 7682 men. All participants were divided into four groups by BMI: underweight ( (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - September 12, 2020 Category: Cardiology Authors: Masato Kajikawa, Tatsuya Maruhashi, Shinji Kishimoto, Haruki Hashimoto, Yuji Takaeko, Takayuki Yamaji, Takahiro Harada, Yu Hashimoto, Yiming Han, Yasuki Kihara, Eisuke Hida, Kazuaki Chayama, Chikara Goto, Farina Mohamad Yusoff, Ayumu Nakashima, Yukihito H Source Type: research

Relationship between sclerostin and coronary tortuosity in postmenopausal females with non-obstructive coronary artery disease
Coronary tortuosity (CT) is commonly encountered in postmenopausal females and is usually present without obstructive lesions. Circulating sclerostin levels are elevated in postmenopausal females. In view of sclerostin's vasculoprotective effect, we aimed to find possible association between circulating sclerostin and CT. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - September 12, 2020 Category: Cardiology Authors: Ismail Mohamed Ibrahim, El-Sayed Mohamed Farag, Mohamed Abd El-Shafy Tabl, Mahmoud Abdelaziz Source Type: research

“Concealed cardiomyopathy” as a cause of previously unexplained sudden cardiac arrest
Background: Genetic heart disease is a common cause of sudden cardiac arrest (SCA) in the young and those without an ischaemic precipitant. Identifying a cause of SCA in these patients allows for targeted care and family screening. Current guidelines recommend limited, phenotype-guided genetic testing in SCA survivors where a specific genetic condition is suspected and genetic testing is not recommended in clinically-idiopathic SCA survivors.Objective: To investigate the diagnostic utility of broad, multi-phenotype genetic testing in clinically-idiopathic SCA survivors. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - September 12, 2020 Category: Cardiology Authors: Julia C. Isbister, Natalie Nowak BAnVetBioSc, Alexandra Butters, Laura Yeates, Belinda GrayMBBS, Raymond W. SyMBBS, Jodie InglesPhD, Richard D. BagnallPhD, Christopher SemsarianMBBS Source Type: research

Comparison of risk stratification models for pregnancy in congenital heart disease
This study was set up as an exploratory study to provide a head-to-head comparison of the 4 most commonly used models: CARPREG, CARPREG II and ZAHARA risk scores and mWHO risk classification. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - September 12, 2020 Category: Cardiology Authors: Nathalie Denayer, Els Troost, B éatrice Santens, Pieter De Meester, Leen Roggen, Philip Moons, Kristel Van Calsteren, Werner Budts, Alexander Van De Bruaene Source Type: research

Spectrum of cardiac involvement in patients with dengue fever
Dengue fever (DF) is an infectious disease of viral origin common in the tropics. Studies on a large number of patients with dengue infection to assess associated cardiac involvement are rare. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - September 12, 2020 Category: Cardiology Authors: Chintan Shah, Govindan Vijayaraghavan, Chandrasekharan C. Kartha Source Type: research

Direct oral anticoagulants in the prevention of stroke in breast cancer patients with atrial fibrillation during adjuvant endocrine therapy: A cohort study
Atrial fibrillation (AF) is a frequent comorbidity in malignant patients. Anticancer therapies complicate anticoagulant strategy. We evaluated the safety and efficacy of long-term use of direct oral anticoagulants (DOACs) in breast cancer women. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - September 12, 2020 Category: Cardiology Authors: Renata Pacholczak-Madej, Stanis ława Bazan-Socha, Lech Zaręba, Anetta Undas, Jerzy Dropiński Source Type: research

Radio-contrast medium exposure and Dialysis risk in patients with chronic kidney disease and congestive heart failure: A case-only study
Background: Dialysis for end stage renal disease is considered a major public health challenge. Pre-existing chronic kidney disease (CKD) and congestive heart failure (CHF) may be independent risk factors for contrast-induced acute kidney injury. The aim of this study is to investigate dialysis risk in patients with CKD and CHF after radio-contrast medium exposure or coronary catheterization.Methods: This case-crossover design used the Health Insurance Database to identify incident dialysis patients with CKD and CHF. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - September 11, 2020 Category: Cardiology Authors: Mei-Yi Wu, Tzu-Ting Chen, Mai-Szu Wu, Yu-Kang Tu Source Type: research

The mid-range ejection fraction following ST elevation myocardial infarction
We thank Drs Zhou et al, for their interest in our work. The authors raised some concerns regarding the use of multivariate Cox proportional regression analysis and whether other confounders were included in the model. The reported hazard ratios were adjusted for the differences among the groups of preserved, mid-range, and reduced ejection fraction (EF). This included age, gender, kidney function, infarct location, troponin values, and medications on discharge [1]. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - September 11, 2020 Category: Cardiology Authors: Mohammad Alkhalil Tags: Letter to the Editor Source Type: research

Left atrial strain as a pre-operative prognostic marker for patients with severe mitral regurgitation
In patients with severe mitral regurgitation (MR), additional echocardiographic indices could be helpful to optimize surgical timing before irreversible left heart myocardial dysfunction has occurred. We investigated the correlation of left atrial (LA) strain by speckle tracking echocardiography with prognosis after mitral surgery for severe MR, and its association with LA fibrosis. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - September 10, 2020 Category: Cardiology Authors: Giulia Elena Mandoli, Maria Concetta Pastore, Giovanni Benfari, Gianluigi Bisleri, Massimo Maccherini, Gianfranco Lisi, Paolo Cameli, Matteo Lisi, Aleksandr Dokollari, Chiara Carrucola, Mariangela Vigna, Gianfranco Montesi, Serafina Valente, Sergio Mondil Source Type: research

Recovery of atrial contractile function after cut-and-sew maze for long-standing persistent valvular atrial fibrillation
The recovery of atrial contractile (AC) after maze has been concerned and even questioned. Now, studied the AC recovery degree and its influencing factors . (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - September 10, 2020 Category: Cardiology Authors: Yan Jin, Hui-Shan Wang, Jin-Song Han, Jian Zhang, Yu-Ji Zhang, Fang-Ran Xin, Yan Yu, Yang Zhao Source Type: research

DNA methylation of hypertension-related genes and effect of riboflavin supplementation in adults stratified by genotype for the MTHFR C677T polymorphism
The interaction between genetic, epigenetic and environmental factors plays an important role in the aetiology of hypertension. GWAS and observational studies link the C677T polymorphism in methylenetetrahydrofolate reductase (MTHFR) with hypertension, while riboflavin, the MTHFR cofactor, has been shown to reduce blood pressure and global DNA methylation in homozygous (TT genotype) individuals. It is currently unclear whether riboflavin modulates DNA methylation of other hypertension-related genes. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - September 10, 2020 Category: Cardiology Authors: Sophia D. Amenyah, Mary Ward, Amy McMahon, Jennifer Deane, Helene McNulty, Catherine Hughes, J.J. Strain, Geraldine Horigan, John Purvis, Colum P. Walsh, Diane J. Lees-Murdock Source Type: research

The differential diagnosis of STEMI should also be taken into account
Strategies to mitigate delay in door-to-balloon(DTB) time [1] should take into account the fact that the differential diagnosis of ST-elevation myocardial infarction(STEMI) includes pulmonary embolism(PE), PE-related paradoxical coronary embolism [2], dissecting aneurysm of the aorta(DAA) [3], and spontaneous tension pneumothorax, the latter either co-existing with STEMI [4], or being the sole and reversible cause of ST segment elevation. Accordingly, the “quickly screening method for high-risk Type 1 MI patients” [1] should include point-of-care TTE and ultrasound to optimise identification of the 4 STEMI-like...
Source: International Journal of Cardiology - September 10, 2020 Category: Cardiology Authors: Oscar M.P. Jolobe Tags: Letter to the Editor Source Type: research

The potentially fatal consequences of fibrinolysis in misdiagnosed subjects with aortic dissection
The assertion that “fibrinolysis with subsequent revascularization is associated with excellent outcomes in STEMI” [1] should be tempered with the recognition that STEMI can be simulated by aortic dissection, a diagnosis which is incompatible with fibrinolytic therapy. The prevalence of STEMI-like aortic dissectio n amounted to 1.5% of the 385 consecutive patients with STEMI-like presentation evaluated by Wang et al. [2]. Subjects so misdiagnosed could experience fatal haemopericadium in the event of administration of fibrinolytic agents [3]. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - September 10, 2020 Category: Cardiology Authors: Oscar M.P. Jolobe Tags: Letter to the Editor Source Type: research

Angiotensin-converting enzyme 2, sex differences, and COVID-19: The missing link
We read with interest the article by Elgendy and Pepine [1] regarding the still poorly understood factors contributing to the observed sex differences in COVID-19 outcomes in men and women. Although the authors made an attempt to connect differential expression of angiotensin-converting enzyme 2 (ACE2) in men and women with COVID-19 outcomes, the proposed link is tenuous. In the study they cite, no differences could be demonstrated in plasma ACE2 between healthy men and women at any age [2]. Recently, a study in heart failure patients (who are known to have lower ACE2 levels) showed a slight (6%), but significantly, higher...
Source: International Journal of Cardiology - September 10, 2020 Category: Cardiology Authors: Jef Van den Eynde, Keir R.G. McCutcheon Tags: Letter to the Editor Source Type: research

Blockade of apoptosis signal-regulating kinase 1 ameliorates cardiac dysfunction in cardiorenal syndrome via enhancing angiogenesis
We have recently read the article by Feby Savira concerning “Inhibition of apoptosis signal-regulating kinase 1 ameliorates left ventricular dysfunction by reducing hypertrophy and fibrosis in a rat model of cardiorenal syndrome” [1]. It indicated that inhibition of apoptosis signal-regulating kinase 1 (ASK1) attenuated left ventricular dysfunction and d iminished cardiac hypertrophy and cardiorenal fibrosis in a rat model of cardiorenal syndrome. The ASK1 inhibitor, GSK2261818A (G226), could be beneficial in the neurodegenerative disorders and inflammatory diseases, owing to its regulatory effect on stress-act...
Source: International Journal of Cardiology - September 10, 2020 Category: Cardiology Authors: Wen-Ying Wei, Zhe-Xun Lian, Ji Yang, Ning Zhang Tags: Letter to the Editor Source Type: research

Economic consequences of rheumatic heart disease: A scoping review
Rheumatic heart disease (RHD) remains endemic in less-resourced regions and countries and results in high medical and non-medical costs to households, health systems, and society. This scoping review maps out the available evidence on the economic impact of RHD and its antecedents and suggests future research priorities. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - September 10, 2020 Category: Cardiology Authors: Chinonso C. Opara, Negeen Aghassibake, David A. Watkins Source Type: research

RE: Inhibition of apoptosis signal-regulating kinase 1 might be a novel therapeutic target in the treatment of cardiorenal syndrome
It is encouraging to see other studies supporting our recent research into the prominent role of ASK1 in the CRS setting [1,2], as well as the role of ASK1 in cardiac remodelling via renin-angiotensin-aldosterone system (RAAS) [3,4] and non-RAAS mechanisms [5]. While ASK1 is predominantly activated by hypertrophic stimuli, its mechanistic involvement in directing the cardiac growth program is still controversial. The study by Liu et al indeed suggest the role of ASK1 in cardiac hypertrophy may be indirect [6]. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - September 10, 2020 Category: Cardiology Authors: Feby Savira, Amanda J. Edgley, Beat M. Jucker, Robert N. Willette, Henry Krum, Darren J. Kelly, Andrew R. Kompa, Bing H. Wang Tags: Letter to the Editor Source Type: research

Upregulation of microRNA-195 might be a novel therapeutic target in the treatment of aortic valve calcification
I read with great interest the article by Yang et al. [1] revealing that upregulation of miR-195 ameliorated aortic valve calcification by repressing von Willebrand factor (VWF) and p38 mitogen-activated protein kinase (p38-MAPK) signaling pathway. It indicated that miR-195/VWF/p38-MAPK signaling pathway played a critical role in the pathogenesis of calcific aortic valve disease (CAVD) and that may be beneficial in discovering a novel therapy for patients with CAVD. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - September 10, 2020 Category: Cardiology Authors: Wei Sun, Lulu Qu Tags: Letter to the Editor Source Type: research

The early dynamic of ECG in takotsubo syndrome presenting with ST-elevation: A comparison with age and gender-matched ST-elevation myocardial infarction
We would like to thank Dr. Madias for the interest in our work and for raising some extremely good scientific questions. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - September 10, 2020 Category: Cardiology Authors: Caroline Scally, WaiKah Choo, Amelia Rudd, Christopher Neil, Nishat Siddiqi, Alice M. Mezincescu, Heather M. Wilson, Michael Frenneaux, Graham Horgan, Paul Broadhurst, Dana K. Dawson Tags: Letter to the Editor Source Type: research

Unusual arterial thrombotic events in Covid-19 patients
COVID-19 infection is commonly complicated with pro-thrombotic state and endothelial dysfunction. While several studies reported a high incidence of venous thromboembolic events. The occurrence of arterial thromboses are yet rarely described and could be underestimated. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - September 9, 2020 Category: Cardiology Authors: C. de Roquetaillade, B.G. Chousterman, D. Tomasoni, M. Zeitouni, E. Houdart, A. Guedon, P. Reiner, R. Bordier, E. Gayat, G. Montalescot, M. Metra, A. Mebazaa Tags: Short communication Source Type: research

Peripheral arterial disease and intermittent claudication in coronary heart disease patients
Peripheral artery disease (PAD) is associated with an increased risk of fatal and non-fatal coronary heart disease (CHD). The aims of the this study were 1) to investigate the prevalence of PAD and suspected PAD in a large population of established CHD patients, and 2) to assess the prevalence and control of risk factors in these patients as well health-related quality of life. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - September 9, 2020 Category: Cardiology Authors: Željko Reiner, Johan De Sutter, Lars Ryden, Erkin Mirrakhimov, Nana Pogosova, Marina Dolzhenko, Zlatko Fras, Kornelia Kotseva, David Wood, Dirk De Bacquer Source Type: research

Is troponin T elevation associated with a poor outcome in infective endocarditis?
We have read with great interest the recently published original paper entitled “Troponin elevation is very common in patients with infective endocarditis and is associated with a poor outcome” by A. Postigo and colleagues [1]. This work concluded that TnT elevation is very common in patients with infective endocarditis (IE), particularly when the high-sensitivity assay is used, and the increase in TnT is associated with higher in-hospital mortality and frequency of complications. According to the protocol detailed in the paper, blood samples were drawn during hospitalization and stored in a lithium heparin con...
Source: International Journal of Cardiology - September 8, 2020 Category: Cardiology Authors: Xiaodong Wei, Yongjun Qian Tags: Letter to the Editor Source Type: research

Troponin T elevation is associated with a poor outcome in infective endocarditis
Thank you for your interest. Due to the retrospective design of our study, troponin (Tn) levels during infective endocarditis hospitalization were not available for all patients as pointed out in Limitations. Table 1 of our manuscript [1] depicts how this problem is common in previous studies and is related to the fact that Tn determination is not supported by current clinical guidelines [2]. Even the moment when Tn levels should be determined is not clear [3]. Since Tn is as a marker of myocardial damage, we recorded the highest level presented by each patient during hospitalization. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - September 8, 2020 Category: Cardiology Authors: Andrea Postigo, Manuel Mart ínez-Sellés Tags: Letter to the editor Source Type: research

Editorial Board
(Source: International Journal of Cardiology)
Source: International Journal of Cardiology - September 8, 2020 Category: Cardiology Source Type: research

Assessment of injury current during leadless pacemaker implantation
The objective is to investigate the role of a local injury current (IC) in leadless pacemaker implantations. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - September 8, 2020 Category: Cardiology Authors: Alexander Breitenstein, Ardan M. Saguner, Alessio Gasperetti, Daniel Hofer, Pascal Koepfli, Fran çois Regoli, Jan Steffel Source Type: research