Embryology of coronary arteries and anatomy/pathophysiology of coronary anomalies. A comprehensive update
This paper reviews new findings in both embryology of coronary arteries and in clinical observations of coronary artery anomalies. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - December 11, 2018 Category: Cardiology Authors: Robert Tomanek, Paolo Angelini Source Type: research

Natriuretic peptides in heart failure: Current achievements and future perspectives
The last two centuries have witnessed countless discoveries in the field of medicine that found their roots in the up growing development of technology as well as in the visionary ideas of brilliant scientists and research groups.One of the most important discoveries in the field of cardiovascular medicine allowed to break the paradigm identifying the heart with mere mechanical pump and to characterize its intriguing endocrine properties. Indeed, the discovery of hormones produced by the cardiac chambers, the natriuretic peptides, represents one of the milestones of the current conception of complexity of integrated human ...
Source: International Journal of Cardiology - December 10, 2018 Category: Cardiology Authors: Massimo Volpe, Allegra Battistoni, Speranza Rubattu Tags: Review Source Type: research

Moderate-to-high intensity inspiratory muscle training improves the effects of combined training on exercise capacity in patients after coronary artery bypass graft surgery: A randomized clinical trial
This study aimed to determine the effects of moderate-to-high intensity IMT  + CT on exercise capacity, respiratory muscle strength, inspiratory muscle endurance, quality of life (QoL), and laboratory biomarkers in patients after CABG who were participants of a phase II cardiac rehabilitation program. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - December 10, 2018 Category: Cardiology Authors: Tamires Daros dos Santos, Sergio Nunes Pereira, Luiz Os ório Cruz Portela, Dannuey Machado Cardoso, Pedro Dal Lago, Naiara dos Santos Guarda, Rafael Noal Moresco, Marisa Bastos Pereira, Isabella Martins de Albuquerque Source Type: research

Trends in prevalence and outcomes of acute coronary syndrome associated with cocaine consumption: The RUTI-cocaine study
In this study, we aimed to analyze the prevalence, and in-hospital and long-term outcomes of acute coronary syndrome (ACS) associated with cocaine consumption (ACS-ACC). (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - December 10, 2018 Category: Cardiology Authors: Carrillo Xavier, Vilalta Victoria, Cediel German, Fernandez-Nofrerias Eduard, Rodriguez-Leor Oriol, Mauri Josepa, Abdul Jawad-Altisent Omar, Garcia-Garcia Cosme, Serra Jordi, Bayes-Genis Antoni Source Type: research

Surgical repair of aortic aneurysms and reduced incidence of dementia
Dementia and aortic aneurysms share clinical risk factors and molecular signaling pathways. However, the association between dementia and aortic aneurysms has not been examined. The potential effects of open surgical repair (OSR) of aortic aneurysms on future dementia events are unknown. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - December 7, 2018 Category: Cardiology Authors: Jen-Chun Wang, Wu-Chien Chien, Nian-Sheng Tzeng, Chi-Hsiang Chung, Chih-Yuan Lin, Shih-Hung Tsai Source Type: research

Silencing salusin β ameliorates heart failure in aged spontaneously hypertensive rats by ROS-relative MAPK/NF-κB pathways in the paraventricular nucleus
Sustained hypertension is a major cause of heart failure in aging hypertensive patients. Salusin β, a novel bioactive peptide of 20 amino acids, has been reported to participate in various cardiovascular diseases, including hypertension. We therefore hypothesized that central knockdown of salusin β might be effective for hypertension-induced heart failure treatment. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - December 7, 2018 Category: Cardiology Authors: Hong-Bao Li, Xiao-Jing Yu, Juan Bai, Qing Su, Mo-Lin Wang, Chan-Juan Huo, Wen-Jie Xia, Qiu-Yue Yi, Kai-Li Liu, Li-Yan Fu, Guo-Qing Zhu, Jie Qi, Yu-Ming Kang Source Type: research

Impact of symptomatic atherosclerosis in patients with pulmonary embolism
Atherosclerosis is associated with increased cardiovascular mortality. Associations between venous thromboembolism and atherosclerosis were recently reported. We aimed to investigate the impact of symptomatic atherosclerosis on adverse outcomes in patients with pulmonary embolism (PE) and to identify significant differences among patients with PE stratified by symptomatic atherosclerosis. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - December 7, 2018 Category: Cardiology Authors: Karsten Keller, Lukas Hobohm, Thomas M ünzel, Mir Abolfazl Ostad Source Type: research

Genetic characterization and genotype-phenotype associations in a large cohort of patients with hypertrophic cardiomyopathy – An ancillary study of the Portuguese registry of hypertrophic cardiomyopathy
We present an ancillary study of the Portuguese Registry of Hypertrophic Cardiomyopathy (PRo-HCM). This is one of the largest HCM genetic studies based on a registry. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - December 7, 2018 Category: Cardiology Authors: Luis Rocha Lopes, Dulce Brito, Adriana Belo, Nuno Cardim, Portuguese Registry of Hypertrophic Cardiomyopathy Source Type: research

Administrative database, observational research and the Tower of Babel
Over the last decades, a number of methodological approaches have been used for depicting the epidemiology and natural history of diseases. Several strategies need to be utilized to obtain a large and comprehensive knowledge of a disease from the real-world perspective. This may be especially relevant when it comes to heart failure (HF), for which intensive effort is necessary to meet research challenges and plan effective disease management programs, quality improvement initiatives, and future clinical trial interventions. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - December 5, 2018 Category: Cardiology Authors: Annamaria Iorio, Gianfranco Sinagra, Andrea Di Lenarda Tags: Editorial Source Type: research

Evaluation of a new ultra-sensitivity troponin I assay in patients with suspected myocardial infarction
Troponin is the gold-standard for diagnostic evaluation of patients with suspected myocardial infarction (MI). We aimed to evaluate the diagnostic and prognostic performance of a new ultra-sensitivity troponin I (us-TnI) assay in patients with suspected MI. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - December 5, 2018 Category: Cardiology Authors: Johannes Tobias Neumann, Nils Arne S örensen, Nicole Rübsamen, Francisco Ojeda, Alina Schock, Parisa Seddighizadeh, Tanja Zeller, Dirk Westermann, Stefan Blankenberg Source Type: research

Handheld versus conventional vascular ultrasound for assessing carotid artery plaque
This study sought to determine whether a handheld vascular ultrasound device could be used as an accurate point-of-care imaging tool for the assessment of carotid artery plaque. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - December 5, 2018 Category: Cardiology Authors: Laura E. Mantella, Kayla Colledanchise, Milena Bullen, Marie-France H étu, Andrew G. Day, Catherine S. McLellan, Amer M. Johri Source Type: research

Anxiety weights down the heart – New evidence for a toxic cardiovascular risk factor
“…. As early as 1806 Napoleon's physician, Corvisart, described the main features of cardiac psychosis: depression, restlessness and irritability, rising in some cases to excitement with confusion, and continuous anxiety.”Joseph Wortis [1] (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - December 5, 2018 Category: Cardiology Authors: Karl-Heinz Ladwig Tags: Editorial Source Type: research

Age-and-sex stratified prevalence of atrial fibrillation in rural Western India: Results of SMART-India, a population-based screening study
Early detection of Atrial Fibrillation (AF) is a public health priority across the globe because AF-related strokes are preventable. Despite an ongoing stroke epidemic in India, a public health strategy for AF screening and treatment is missing because the epidemiology of AF in India remains poorly defined. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - December 5, 2018 Category: Cardiology Authors: Apurv Soni, Sunil Karna, Nisha Fahey, Saket Sanghai, Harshil Patil, Shyamsundar Raithatha, Sunil Thanvi, Somashekhar Nimbalkar, Ben Freedman, Jeroan Allison, David D. McManus Source Type: research

The challenge of risk stratification in Ebstein's anomaly
Ebstein's anomaly (EA) is characterized by a disturbed right heart development due to an incomplete delineation of variable degree of the septal, posterior and anterior leaflets of the tricuspid valve leading to a displacement of the valvular hinge points and the functional tricuspid annulus to the apex and right ventricular (RV) outflow tract. The consequence is an “atrialization” of the inlet portion of the right ventricle (RV). The myocardium of this atrialized part of the RV is thin, associated with a severely reduced or absent contractility. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - December 5, 2018 Category: Cardiology Authors: Tobias Rutz, Andreas K ühn Tags: Editorial Source Type: research

Coronary stenosis and left ventricular function - Major prognostic factors in patients with ischemic heart disease: Has something changed in the era of “precision medicine”?
In this issue of International Journal of Cardiology publication, “Prognostic impact of residual stenosis (RS) after percutaneous coronary intervention (PCI) in patients with ischemic heart failure (HF) – a report from the CHART-2 study” (NCT00418041) by Hao et al. [1], in a large prospective hospital-based study, it was shown that in 851/1307 (65.1%) post-P CI patients, who had RS ≥70% with symptomatic HF in the median follow-up period of 3.2 years, RS had a clinically significant impact on higher all-cause mortality. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - December 5, 2018 Category: Cardiology Authors: Miodrag Ostojic, Bojan M. Stanetic, Tamara Kovacevic-Preradovic, Darko Boljevic, Dusko Vulic Tags: Editorial Source Type: research

Lessons learned from cryoballon pulmonary vein isolation in elderly patients – Should we go “cold for the old”?
Incidence and prevalence of atrial fibrillation (AF) increases with age and occurs in>5% of patients aged over 75  years [1]. In recent years, it turned out that AF catheter ablation is superior to antiarrhythmic drug-based rhythm control [2]. Thus, catheter ablation in AF patients has become a class-I-indication in patients that remain symptomatic on antiarrhythmic therapy and can even be considered as first -line therapy [3]. However, most AF ablation trials did not include patients over 75 years of age [2,4]. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - December 5, 2018 Category: Cardiology Authors: Alexander Pott, Tillman Dahme Tags: Editorial Source Type: research

To screen or not to screen, what do the Pacific Island athletes teach us?
It is well established, that physical activity confers substantial health benefits and prolongs life [1]. Paradoxically, however, intensive exercise may also act as a trigger for life-threatening ventricular arrhythmias in case of an underlying cardiac disease [2], occasionally leading to sudden death of a young and apparently healthy person, a catastrophic event with far-reaching implications for families and communities involved. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - December 5, 2018 Category: Cardiology Authors: Aapo L. Aro Tags: Editorial Source Type: research

Cost-comparison of third generation transcatheter aortic valve implantation (TAVI) devices in the German Health Care System
Transcatheter aortic valve implantation (TAVI) has a substantial impact on daily cardiovascular care delivery based on issues such as cost effectiveness and economic value within a restricted health care budget. Until now, potential financial benefits of third generation valve models have not been evaluated in a real-world setting. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - December 4, 2018 Category: Cardiology Authors: Verena Veulemans, Kerstin Piayda, Shazia Afzal, Amin Polzin, Christine Quast, Christian Jung, Ralf Westenfeld, Tobias Zeus, Malte Kelm, Katharina Hellhammer Source Type: research

Haemodynamic effects of pharmacologic stress with adenosine in patients with left ventricular systolic dysfunction
In patients with heart failure, downregulation of adenosine receptor gene expression and impaired adenosine-related signal transduction may result in a diminished response to adenosine. This may have implications for cardiac stress testing. We evaluated the haemodynamic response to intravenous adenosine in patients with left ventricular systolic dysfunction (LVSD) undergoing stress cardiovascular magnetic resonance imaging (CMR). (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - December 4, 2018 Category: Cardiology Authors: Gaurav S. Gulsin, Ahmed M.S.E.K. Abdelaty, Abhishek Shetye, Florence Y. Lai, Amrita Bajaj, Indrajeet Das, Aparna Deshpande, Praveen P.G. Rao, Jeffrey Khoo, Gerry P. McCann, Jayanth R. Arnold Source Type: research

Type 1 diabetes is associated with increased risk of atrial fibrillation
We read with great interest the article titled “Type 1 and type 2 diabetes mellitus and incidence of seven cardiovascular diseases.” by Larsson et al. [1]. The authors present a study regarding the association of type 1 diabetes mellitus (T1DM) with the incidence of seven cardiovascular diseases and conclude that there is no association betw een T1DM and atrial fibrillation (AF) [1]. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - December 4, 2018 Category: Cardiology Authors: Michael Spartalis, Eleni Tzatzaki, Stavroula A. Paschou, Eleftherios Spartalis Tags: Letter to the Editor Source Type: research

A new score based on the PEGASUS-TIMI 54 criteria for risk stratification of patients with acute myocardial infarction
Acute myocardial infarction (AMI) patients are at increased risk of death and recurrent ischemic events. We aimed to elaborate a risk score, based on the PEGASUS-TIMI 54 criteria, to predict mortality and non-fatal AMI in AMI patients. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - December 4, 2018 Category: Cardiology Authors: Nicola Cosentino, Jeness Campodonico, Pompilio Faggiano, Monica De Metrio, Mara Rubino, Valentina Milazzo, Marco Sbolli, Carlotta Perego, Martino Provini, Alice Bonomi, Fabrizio Veglia, Antonio L. Bartorelli, Giancarlo Marenzi Source Type: research

Is high thromboembolic risk not really associated with low time in therapeutic range in patients with prosthetic heart valves?
We have recently read with great interest the article reported by Poli et al. which was published in the last issue of International Journal of Cardiology [1]. We appreciate the authors for valuable contribution to the literature, however, we believe that there are several major drawbacks that need to be addressed. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - December 4, 2018 Category: Cardiology Authors: Ahmet Guner, Macit Kalcik, Mustafa Ozan Gursoy, Mehmet Ozkan Tags: Letter to the Editor Source Type: research

Anti-anginal drugs: Systematic review and clinical implications
The cornerstone of the treatment of patients affected by stable angina is based on drugs administration classified as first (beta-blockers, calcium channel blockers, short acting nitrates) or second line treatment (long-acting nitrates, ivabradine, nicorandil, ranolazine and trimetazidine). However, few data on comparison between different classes of drugs justify that one class of drugs is superior to another. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - December 4, 2018 Category: Cardiology Authors: Rita Pavasini, Paolo G. Camici, Filippo Crea, Nicolas Danchin, Kim Fox, Athanasios J. Manolis, Mario Marzilli, Giuseppe M.C. Rosano, Jos é L. Lopez-Sendon, Fausto Pinto, Cristina Balla, Roberto Ferrari Source Type: research

Structurally-based electrical predictors of atrial arrhythmias
Mechanisms of atrial tachycardias (AT) can be defined as reentrant (micro- or macro-) or focal (automatic or triggered) once the rhythm is expressed. However, in the absence of typical atrial flutter or inducible arrhythmia, it is difficult to predict the location or substrates for atrial arrhythmias. This is distinct from VT, in which low voltage channels in sinus rhythm and other predictors may help in identification [1]. ATs provide some hints, however, such as the fact that up to 40% of ATs after prior ablation for atrial fibrillation (AF) are due to microreentry [2], which requires areas of slow conduction which often...
Source: International Journal of Cardiology - December 4, 2018 Category: Cardiology Authors: Albert J. Rogers, Nosheen F. Moosvi, Chad Brodt, Sanjiv M. Narayan Tags: Editorial Source Type: research

Further insights into CRT delivered through a trans septal LV endocardial lead
Cardiac resynchronization therapy (CRT) is an effective electrical therapy for patients with drug refractory heart failure symptoms, severely impaired left ventricular systolic function and prolonged QRS duration measured by surface ECG. Improvement in quality of life, exercise tolerance, heart failure hospitalizations and mortality have all been demonstrated; however, a sizeable proportion of patients fail to derive benefit (Daubert et al. 2012). (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - December 4, 2018 Category: Cardiology Authors: J.M. Behar Tags: Editorial Source Type: research

Impact of direct stenting on myocardial injury assessed by cardiac magnetic resonance imaging and prognosis in ST-elevation myocardial infarction
The results of studies investigating the clinical benefit of a direct stenting (DS) strategy in ST-elevation myocardial infarction (STEMI) are inconsistent and data regarding cardiac magnetic resonance (CMR) parameters of myocardial injury are lacking. The aim of this study was to investigate the effect of DS on myocardial damage in comparison to a conventional stenting technique (CS) with predilation in patients with reperfused STEMI. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - December 3, 2018 Category: Cardiology Authors: Mohammed Saad, Thomas Stiermaier, Georg Fuernau, Janine P öss, Suzanne de Waha-Thiele, Steffen Desch, Holger Thiele, Ingo Eitel Source Type: research

Comparison of fourteen rule-out strategies for acute myocardial infarction
The clinical availability of high-sensitivity cardiac troponin (hs-cTn) has enabled the development of several innovative strategies for the rapid rule-out of acute myocardial infarction (AMI). Due to the lack of direct comparisons, selection of the best strategy for clinical practice is challenging. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - December 3, 2018 Category: Cardiology Authors: Karin Wildi, Jasper Boeddinghaus, Thomas Nestelberger, Raphael Twerenbold, Patrick Badertscher, Desiree Wussler, Maria Rubini Gim énez, Christian Puelacher, Jeanne du Fay de Lavallaz, Sebastian Dietsche, Joan Walter, Nikola Kozhuharov, Beata Morawiec, Ò Source Type: research

The role of CD27-CD70 signaling in myocardial infarction and cardiac remodeling
CD4+ T cells are key players in regulating the inflammatory processes and physiological repair mechanisms engaged after acute myocardial infarction (AMI). Although signaling though the CD27-CD70 co-stimulatory pathway are known to be important in CD4+ T cell activation and proliferation in certain contexts, the role of the CD27-CD70 pathway in AMI remains unclear. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - December 3, 2018 Category: Cardiology Authors: Wei Li, Fengxiao Zhang, Chenhui Ju, Suying Lv, Kai Huang Source Type: research

The FAST-MI 2005-2010-2015 registries in the light of the COMPASS trial: The COMPASS criteria applied to a post-MI population
The COMPASS trial assessed the impact of adding low dose rivaroxaban to aspirin in selected patients (pts). After an acute myocardial infarction (MI), when dual antiplatelet treatment is no longer needed, patients might be eligible for aspirin/rivaroxaban co-therapy. The characteristics and risks of such a population are unclear. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - December 3, 2018 Category: Cardiology Authors: Fran çois Schiele, Etienne Puymirat, Jean Ferrières, Tabassome Simon, Keith A.A. Fox, John Eikelboom, Nicolas Danchin, FAST-MI investigators Source Type: research

Second-generation cryo-pulmonary vein isolation for persistent atrial fibrillation: Is it really time to think out of the ‘veins’?
In the last two decades, we have witnessed the evolution of radiofrequency catheter ablation (RFCA) from an experimental procedure to a well-established treatment option for many atrial fibrillation (AF) patients. Pulmonary veins (PV) represent one of the main contributing drivers, however, several atrial sites and structural remodeling may play a critical role in the maintenance and perpetuation of the arrhythmia, as long as it progresses to more persistent form [1]. Nevertheless, PV isolation (PVI) gained widespread consensus, whereas commonly applied ablation sets (e.g. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - December 3, 2018 Category: Cardiology Authors: Giuseppe Ciconte Tags: Editorial Source Type: research

Advanced care planning in adult congenital heart disease: A life-long journey
Adults born with congenital heart disease (CHD) represent a remarkable success story in the field of cardiology and cardiac surgery. In the 1950s, survival of children born with CHD was only around 15%. Due to the advances in pediatric cardiology, innovations in surgical and interventional procedures, more than 90% of children nowadays born with CHD are expected to reach adulthood [1]. However, behind this success story many challenges remain. Although the majority of these patients had operation(s) in childhood they are rarely cured, but rather palliated and therefore need to live with a chronic disease. (Source: Internat...
Source: International Journal of Cardiology - December 3, 2018 Category: Cardiology Authors: Margarita Brida Tags: Editorial Source Type: research

Mid-term outcomes after percutaneous interventions in coronary bifurcations
The optimal treatment of patients undergoing percutaneous coronary interventions (PCI) for lesions located at coronary bifurcations is still debated. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - December 2, 2018 Category: Cardiology Authors: Marco Zimarino, Carlo Briguori, Ignacio J. Amat-Santos, Francesco Radico, Emanuele Barbato, Alaide Chieffo, Plinio Cirillo, Ricardo A. Costa, Andrejs Erglis, Habib Gamra, Robert J. Gil, Vojko Kanic, Sasko A. Kedev, Nicola Maddestra, Sunao Nakamura, Marian Source Type: research

Impact of dronedarone on the risk of myocardial infarction and stroke in atrial fibrillation patients followed in general practices in Germany
The goal of this study was to analyze the impact of dronedarone on the risk of myocardial infarction and stroke in atrial fibrillation (AF) patients followed in general practices in Germany. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - December 1, 2018 Category: Cardiology Authors: Joachim R. Ehrlich, Christiane Look, Karel Kostev, Carsten W. Israel, Andreas Goette Source Type: research

The imminent epidemic of atrial fibrillation and its concomitant diseases – Myocardial infarction and heart failure - A cause for concern
Atrial fibrillation (AF) is increasingly common in the general population. It often coincides with myocardial infarction (MI) and heart failure (HF) which are also diseases in older adults. All three conditions share common cardiovascular risk factors. While hypertension and obesity are central risk factors for all three diseases, smoking and diabetes appear to have less impact on AF. To date, age is the single most important risk factor for AF in the general population. Further, epidemiological studies suggest a strong association of AF to MI and HF. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - November 30, 2018 Category: Cardiology Authors: Christin S. B örschel, Renate B. Schnabel Tags: Review Source Type: research

Treatment of cardiac sarcoidosis: A comparative study of steroids and steroids plus immunosuppressive drugs
We aimed to compare the efficacy of steroids alone or associated with immunosuppressive drugs for the prevention of relapse in cardiac sarcoidosis (CS). (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - November 30, 2018 Category: Cardiology Authors: Thomas Ballul, Raphael Borie, Bruno Crestani, Eric Daugas, Vincent Descamps, Philippe Dieude, Antoine Dossier, Fabrice Extramiana, Damien van Gysel, Thomas Papo, Karim Sacre Tags: Short communication Source Type: research

It is time to have better oversite and accountability in performing too many not indicated percutaneous coronary interventions in patients with chronic total occlusions
With the introduction of percutaneous coronary intervention (PCI) by Dr. Gruntzig [1], treatment of coronary disease underwent revolution and led to PCI being one of most commonly performed procedures in the world. Since the first PCI, many decades had passed with numerous clinical trials that are available to address various clinical scenarios. It is now clear that real mortality benefit of PCI occurs mostly in the treatment of patients with acute coronary syndrome [2]. PCI performed in the setting of stable coronary artery disease has rarely shown any mortality benefit even in the case of proven ischemia [3,4]. (Source: ...
Source: International Journal of Cardiology - November 29, 2018 Category: Cardiology Authors: Mohammad Reza Movahed Tags: Editorial Source Type: research

Custom tailoring of medical implants for pulmonary artery bifurcation stenosis
Despite considerable evolution in stent technology and implantation techniques pulmonary bifurcation stenosis (PBS) remains one of the complex lesion subsets challenging the interventional cardiologist. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - November 29, 2018 Category: Cardiology Authors: Ina Michel-Behnke Tags: Editorial Source Type: research

Persistent atrial fibrillation: A systematic review and meta-analysis of invasive strategies
Persistent atrial fibrillation (AF) is associated with higher stroke and mortality risk than paroxysmal AF (pAF). Outcomes of catheter or surgical ablation are worse in patients with persistent AF than in pAF, and the optimal invasive rhythm control strategy has not been established. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - November 29, 2018 Category: Cardiology Authors: Wouter R. Berger, Eva R. Meulendijks, Jacqueline Limpens, Nicoline W.E. van den Berg, Jolien Neefs, Antoine H.G. Driessen, S ébastien P.J. Krul, Wim Jan P. van Boven, Joris R. de Groot Source Type: research

Corrigendum to “M2b macrophages reduce early reperfusion injury after myocardial ischemia in mice: A predominant role of inhibiting apoptosis via A20” [Int. J. Cardiol. 245 (2017) 228–235]
The authors regret that the affiliation ‘Key Laboratory on Assisted Circulation, Ministry of Health, Guangzhou 510080, China’ was not included in the original article and this has now been included. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - November 29, 2018 Category: Cardiology Authors: Yuan Yue, Xiao Yang, Kangni Feng, Lexun Wang, Jian Hou, Bo Mei, Han Qin, Mengya Liang, Guangxian Chen, Zhongkai Wu Tags: Corrigendum Source Type: research

Cardiac valve calcification and use of anticoagulants: Preliminary observation of a potentially modifiable risk factor
Direct oral anticoagulant (DOAC) has been recently introduced in the clinical practice. Rather than interfering with vitamin K-dependent posttranscriptional modification of various proteins, DOACs selectively inhibit factors involved in the coagulation cascade. In particular, in contrast with Warfarin, Rivaroxabn does not interfere with activation of matrix Gla Protein (MGP), a potent vascular calcification Inhibitor. We herein sought to investigate the impact of Rivaroxaban and Warfarin on cardiac valve calcifications in a cohort of moderate-to advanced CKD patients. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - November 29, 2018 Category: Cardiology Authors: Luca Di Lullo, Giovanni Tripepi, Claudio Ronco, Graziella D'Arrigo, Vincenzo Barbera, Domenico Russo, Biagio Raffaele Di Iorio, Massimo Uguccioni, Ernesto Paoletti, Maura Ravera, Maria Fusaro, Antonio Bellasi Source Type: research

It is time to have better oversite and accountability in performing many not indicated percutaneous coronary interventions in patients with chronic total occlusions
With the introduction of percutaneous coronary intervention (PCI) by Dr. Gruntzig [1], treatment of coronary disease underwent revolution and led to PCI being one of most commonly performed procedures in the world. Since the first PCI, many decades had passed with numerous clinical trials that are available to address various clinical scenarios. It is now clear that real mortality benefit of PCI occurs mostly in the treatment of patients with acute coronary syndrome [2]. PCI performed in the setting of stable coronary disease has rarely shown any mortality benefit even in the case of proven ischemia [3,4]. (Source: Interna...
Source: International Journal of Cardiology - November 29, 2018 Category: Cardiology Authors: Mohammad Reza Movahed Tags: Editorial Source Type: research

Antithrombotic therapy after acute coronary syndromes in patients with atrial fibrillation: Shouldn't we pay more attention to the risk of ischemic and thromboembolic events?
The management of antithrombotic therapy in patients with atrial fibrillation (AF) presenting an acute coronary syndrome (ACS) or undergoing percutaneous coronary intervention (PCI) is particularly complex. Oral anticoagulation (OAC) is superior to single or dual antiplatelet therapy (DAPT) for the prevention of thromboembolic complications (stroke and systemic embolism) due to AF, whereas DAPT with low-dose aspirin and a P2Y12 inhibitor is the recommended antithrombotic treatment to prevent ischemic events (myocardial infarction and stent thrombosis) in patients with ACS or undergoing PCI. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - November 29, 2018 Category: Cardiology Authors: Jos é Luis Ferreiro, Joan Antoni Gómez-Hospital Tags: Editorial Source Type: research

Editorial Board
(Source: International Journal of Cardiology)
Source: International Journal of Cardiology - November 28, 2018 Category: Cardiology Source Type: research

Clinical importance of atrial cardiomyopathy
Atrial fibrillation (AF) is the most common cause of thromboembolic complications. The risk of suffering a thromboembolic complication correlates with the CHA2DS2-VASc score identifying patients at increased risk. It is based on patient age, prior thromboembolic events, and clinical comorbidities, but not based on pathophysiological changes in different types of atrial cardiomyopathy (ACM) as classified in the expert consensus on ACM published in 2016. The impact of different types of ACM has also been acknowledged in the expert consensus statement on catheter ablation of atrial fibrillation. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - November 28, 2018 Category: Cardiology Authors: Matthias Hammw öhner, Alicia Bukowska, Wisnu Mahardika, Andreas Goette Source Type: research

A priori-defined Mediterranean-like dietary pattern predicts cardiovascular events better in north Europe than in Mediterranean countries
The Mediterranean Diet (MD) is a model of healthy eating contributing to a favorable health status, but its clinical usefulness is still debated. The aim of this study was to relate the adherence to MD with the incidence of cardio/cerebro-vascular events (VEs) in north and south European participants of the IMPROVE study. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - November 28, 2018 Category: Cardiology Authors: Fabrizio Veglia, Damiano Baldassarre, Ulf de Faire, Sudhir Kurl, Andries J. Smit, Rainer Rauramaa, Philippe Giral, Mauro Amato, Alessandro Di Minno, Alessio Ravani, Beatrice Frigerio, Samuela Castelnuovo, Daniela Sansaro, Daniela Coggi, Alice Bonomi, Calo Source Type: research

Emerging roles of proteoglycans in cardiac remodeling
Cardiac remodeling is the response of the heart to a range of pathological stimuli. Cardiac remodeling is initially adaptive; however, if sustained, it ultimately causes adverse clinical outcomes. Cardiomyocyte loss or hypertrophy, inflammation and fibrosis are hallmarks of cardiac remodeling. Proteoglycans, which are composed of glycosaminoglycans and a core protein, are a non-structural component of the extracellular matrix. The lack of proteoglycans results in cardiovascular defects during development. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - November 28, 2018 Category: Cardiology Authors: Xiaoya Wang, Yi Lu, Yao Xie, Jian Shen, Meixiang Xiang Source Type: research

Comparison of biomechanical properties in ascending aortic aneurysms of patients with congenital bicuspid aortic valve and Marfan syndrome
We examined the hemodynamic profiles and ultrastructures of aneurysmal specimens, focusing on vascular remodeling to better understand AscAA pathogenesis. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - November 26, 2018 Category: Cardiology Authors: Junfeng Yan, Ann-Cathrin Lehsau, Benjamin Sauer, Barbara Pieper, Salah A. Mohamed, Mechanistic Interrogation of Bicuspid Aortic Valve associated Aortopathy (MIBAVA) Leducq Consortium Source Type: research

What can we use to predict late recurrence after catheter ablation of atrial fibrillation?
Catheter ablation (CA) is much more effective in reducing symptoms and rhythm control compared to anti-arrhythmic drugs and recommended as a first-line treatment for patients with symptomatic atrial fibrillation (AF) [1]. In spite of the ever-increasing evidences on benefits of CA, AF recurrence is common post CA and fewer AF patients are willing to accept ablation treatment in the clinical practice, which need to be taken consideration by the physicians before making the decision. Many clinical diseases or factors such as hypertension, type 2 diabetes mellitus, untreated obstructive sleep apnea, metabolic syndrome, chroni...
Source: International Journal of Cardiology - November 26, 2018 Category: Cardiology Authors: Hai Deng, Shulin Wu Tags: Editorial Source Type: research

Rare diseases hiding in the cardiomyopathy clinic - The importance of seeing and observing
“You see, but you do not observe.”(Sherlock Holmes - A scandal in Bohemia) (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - November 26, 2018 Category: Cardiology Authors: Juan Pablo Kaski, Sian Chivers Tags: Editorial Source Type: research

Left ventricular mass independently associates with 24-hour sodium excretion in young masked hypertensive adults: The African-PREDICT study
Due to the known contribution of excess sodium intake on elevations in blood pressure, salt reduction regulations are being introduced in countries all over the world. To study the contribution of sodium intake on cardiovascular disease development, we determined whether left ventricular mass associates with sodium excretion in young adults free from overt cardiovascular disease and those with masked hypertension. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - November 24, 2018 Category: Cardiology Authors: Bianca van der Westhuizen, Aletta E. Schutte, Lebo Gafane-Matemane, Ruan Kruger Source Type: research