Cardiopulmonary dysfunction in adults with a small, unrepaired ventricular septal defect: A long-term follow-up
There are increasing reports of cardiac and exercise dysfunction in adults with small, unrepaired ventricular septal defects (VSDs). The primary aim of this study was to evaluate pulmonary function in adults with unrepaired VSDs, and secondly to assess the effects of 900  μg salbutamol on lung function and exercise capacity. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 27, 2020 Category: Cardiology Authors: Filip Eckerstr öm, Christian Emil Rex, Marie Maagaard, Johan Heiberg, Sune Rubak, Andrew Redington, Vibeke Elisabeth Hjortdal Source Type: research

Echocardiographic predictors of severe right ventricular diastolic dysfunction in tetralogy of Fallot: Relations to patient outcomes
Previous studies have described echocardiographic indices of right ventricular (RV) diastolic function in patients with tetralogy of Fallot (TOF) but these indices have not been validated against invasive hemodynamic data. The purpose of this study was to determine echocardiographic predictors of severe RV diastolic dysfunction, and the impact of severe RV diastolic dysfunction on transplant-free survival. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 27, 2020 Category: Cardiology Authors: Alexander C. Egbe, Patricia A. Pellikka, William R. Miranda, Crystal Bonnichsen, Yogesh N.V. Reddy, Barry A. Borlaug, Heidi M. Connolly Source Type: research

Comparison of the self-expanding Evolut-PRO transcatheter aortic valve to its predecessor Evolut-R in the real world multicenter ATLAS registry
The Evolut PRO self-expanding transcatheter aortic valve has been designed to feature an outer pericardial wrap that aims to reduce paravalvular regurgitation (PVR) rates. Medium-term clinical outcomes, compared to its predecessor Evolut R, in a real-world setting, have not been investigated. The aim of the present study was to compare the two valves with regards to peri-procedural complications, early outcomes and mid-term survival. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 27, 2020 Category: Cardiology Authors: Konstantinos Kalogeras, Neil Ruparelia, Tito Kabir, Richard Jabbour, Toru Naganuma, Manolis Vavuranakis, Sunao Nakamura, Brian Wang, Sayan Sen, Nearchos Hadjiloizou, Iqbal S. Malik, Ghada Mikhail, Miles Dalby, Vasileios Panoulas Source Type: research

Are recurrence of ischemic mitral regurgitation and left ventricular reverse remodeling after restrictive annuloplasty ring dependent?
This meta-analysis investigates MR recurrence and degree of left ventricular reverse remodeling (LVRR) in CIMR patients in mitral annuloplasty employing different ring designs. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 27, 2020 Category: Cardiology Authors: Linda Renata Micali, Gianmarco Parise, Amalia Ioanna Moula, Yazeed Alayed, Orlando Parise, Francesco Matteucci, Monique de Jong, Cecilia Tetta, Sandro Gelsomino Source Type: research

Device deformation and left pulmonary artery obstruction after transcatheter patent ductus arteriosus closure in preterm infants
This study describes the outcomes and complications of transcatheter closure of patent ductus arteriosus (PDA) in preterm infants weighing (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 27, 2020 Category: Cardiology Authors: Yu-Hsuan Chien, Hsuan-Hui Wang, Ming-Tai Lin, Hsin-Chia Lin, Chun-Wei Lu, Shuenn-Nan Chiu, Mei-Hwan Wu, Jou-Kou Wang, Chun-An Chen Source Type: research

22q11.2 deletion syndrome is associated with increased mortality in adults with tetralogy of Fallot and pulmonary atresia with ventricular septal defect
22q11.2 Deletion syndrome (22q11.2DS) is common in patients with tetralogy of Fallot (TOF) or pulmonary atresia with ventricular septal defect (PA/VSD) and is associated with worse outcomes in children. Whether this impaired prognosis is also translated into adulthood is unknown, as data in adult patients are limited. We aimed to compare long-term outcomes in adults with TOF or PA/VSD both with and without 22q11.2DS. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 27, 2020 Category: Cardiology Authors: Dirkjan Kauw, Odilia I. Woudstra, Klaartje van Engelen, Folkert J. Meijboom, Barbara J.M. Mulder, Mark J. Schuuring, Berto J. Bouma Source Type: research

Long-term follow-up and predictors of target lesion failure after implantation of everolimus-eluting bioresorbable scaffolds in real-world practice
Bioresorbable scaffolds (BRS) have been shown to be inferior to drug-eluting stents in randomized trials. Nevertheless, patients treated during daily routine differ from those treated within randomized trials and thus need further long-term evaluation. The present investigation aims to address this lack. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 27, 2020 Category: Cardiology Authors: Jens Wiebe, Moritz Baquet, Oliver D örr, Petra Hoppmann, David Jochheim, Tobias Rheude, Niklas Boeder, David Grundman, Florian Blachutzik, Hans Theiss, Salvatore Cassese, Felix J. Hofmann, Sarah Gschwendtner, Albrecht Elsässer, Steffen Massberg, Christi Source Type: research

Renal function and Fontan patients: What is the real impact in the long-term outcomes?
The Fontan procedure is usually the final step in the surgical treatment of children with univentricular physiology, allowing for a better survival of this population into adulthood. While separating the systemic from the pulmonary venous blood returns, the Fontan circulation is characterized by the absence of a sub pulmonary ventricle and abnormal, non-pulsatile flow in the lungs. This leads to elevated central venous pressure and a relatively low cardiac output, in a state of chronic ventricular volume deprivation [1]. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 27, 2020 Category: Cardiology Authors: Maria Ang élica Binotto Tags: Editorial Source Type: research

Improved percent-predicted peak VO2 is associated with lower risk of hospitalization in patients with coronary heart disease. Analysis from the FRIEND registry
This study was undertaken to examine the association between percentage of age-predicted VO2peak and all-cause hospital readmission in cardiac outpatients who were referred to an exercise-based secondary prevention program. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 24, 2020 Category: Cardiology Authors: G. Chiaranda, J. Myers, R. Arena, L. Kaminsky, B. Sassone, G. Pasanisi, S. Mandini, M. Pizzolato, M. Franchi, N. Napoli, F. Guerzoni, L. Caruso, G. Mazzoni, G. Grazzi Source Type: research

Atrial function in Fontan patients assessed by CMR: Relation with exercise capacity and long-term outcomes
To assess the role of atrial function on exercise capacity and clinical events in Fontan patients. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 24, 2020 Category: Cardiology Authors: Jelle P.G. van der Ven, Tarek Alsaied, Saeed Juggan, Sjoerd S.M. Bossers, Eva van den Bosch, Livia Kapusta, Irene M. Kuipers, Lucia J.M. Kroft, Arend D.J. ten Harkel, Gabrielle G. van Iperen, Rahul H. Rathod, Willem A. Helbing Source Type: research

Structural brain abnormalities in adults with congenital heart disease: Prevalence and association with estimated intelligence quotient
Little is known about the prevalence of structural brain abnormalities and cognitive functioning in the growing population of patients with adult congenital heart disease (ACHD). Thus, our aim was to assess structural abnormalities on brain magnetic resonance imaging (MRI) and their association with intelligence quotient (IQ) in ACHD patients. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 24, 2020 Category: Cardiology Authors: Nora Kessler, Maria Feldmann, Ladina Schlosser, Sarah Rometsch, Peter Brugger, Raimund Kottke, Walter Knirsch, Angela Oxenius, Matthias Greutmann, Beatrice Latal Source Type: research

Effect of the baseline pulse wave velocity on short term and long term blood pressure control in primary hypertension
Arterial stiffness may affect antihypertensive response to antihypertensive treatment. However, sufficient clinical evidence is lacking. This longitudinal study aimed to evaluate the effect of baseline arterial stiffness measured by the brachial-ankle pulse wave velocity (baPWV) on response to short-term and long-term enalapril-based treatment in 3310 hypertensive adults from the China Stroke Primary Prevention Trial (CSPPT). (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 24, 2020 Category: Cardiology Authors: Y. Fan, W. Gao, J. Li, F. Fan, X. Qin, L. Liu, X. Cheng, X. Xu, X. Wang, B. Wang, Y. Huo Source Type: research

Transcriptional evaluation of relaxin and endothelin-1 axis in heart failure patients: First evidence of its involvement during left ventricular assist device support
Left ventricular assist devices (LVAD) are implanted in patients with end-stage heart failure (ESHF) as a mechanical support for the failing myocardium, which is characterized by an activation of the neuro-hormonal system, with release of vasoactive mediators, such as endothelin (ET) and relaxin (RLX). The aim of this study was to evaluate whether LVAD is able to modulate the RLX and ET-1 system expression in ESHF patients. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 24, 2020 Category: Cardiology Authors: Manuela Cabiati, Luca Botta, Chiara Caselli, Silvia Del Ry Source Type: research

Use of Lifetech ™ Konar-MF, a device for both perimembranous and muscular ventricular septal defects: A multicentre study
The objective of this study was to evaluate the safety and efficacy of transcatheter closure of ventricular septal defects (VSD) using the LifeTech ™ multifunctional occluder device (MF-Konar). (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 22, 2020 Category: Cardiology Authors: Ibrahim Cansaran Tanidir, Osman Baspinar, Murat Saygi, Mehmet Kervancioglu, Alper Guzeltas, Ender Odemis Source Type: research

Temporal trends in cause-specific readmissions and their risk factors in heart failure patients in Sweden
This study aimed to determine the temporal short- and long-term trends of cause-specific rehospitalization and their risk factors in a Swedish context. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 21, 2020 Category: Cardiology Authors: Xiaotong Cui, Jingmin Zhou, Aldina Pivodic, Ulf Dahlstr öm, Junbo Ge, Michael Fu Source Type: research

Health economic evaluation of implantable cardioverter defibrillators in hypertrophic cardiomyopathy in adults
Hypertrophic cardiomyopathy is a heterogeneous disease in which an implantable cardioverter defibrillator (ICD) effectively prevents sudden cardiac death in at-risk individuals. Nevertheless, the cost-effectiveness of ICDs in this specific patient group has not been evaluated. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 20, 2020 Category: Cardiology Authors: Peter Magnusson, Anders Wimo Source Type: research

Should we predict post-operative atrial fibrillation with atrial cardiomyopathy biomarkers?
In the current issue of the International Journal of Cardiology, the article by Rizvi et al. adds significant evidence to the current body of knowledge regarding the pathophysiological mechanisms involved in post cardiac surgery new onset atrial fibrillation (PoAF) [1]. The incidence [2], predictive factors [3] and prognostic value of this PoAF have been thoroughly studied, but no randomized study has managed to obtain a decrease in incidence or an improvement in prognosis. Moreover, it is still unclear whether PoAF should be treated as an epiphenomenon linked to the acute setting and cardiac injury, or as the first sympto...
Source: International Journal of Cardiology - February 20, 2020 Category: Cardiology Authors: Charles Guenancia, Audrey Sagnard, Olivier Bouchot, Luc Lorgis Tags: Editorial Source Type: research

Comparing the effects of different management strategies on long-term outcomes for significant coronary stenosis in patients with Takayasu arteritis
The long-term outcomes and optimal treatment strategy for patients with Takayasu arteritis (TA) and significant coronary stenosis remain unclear. We aim to investigate the prognosis of these patients according to the initial management strategy. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 19, 2020 Category: Cardiology Authors: Hui Wang, Yang Zhang, Zhujun Shen, Ligang Fang, Zhenyu Liu, Shuyang Zhang Source Type: research

Body mass index and in-hospital outcomes in patient's ≥80 years with ST Elevation Myocardial Infarction. Results from low income country without coronary intervention
In most scenarios from low/middle income countries, pharmacological approach for ST elevation Myocardial Infarction is still use. In these setting and increase proportion of elderly patients is awaited. So it is also expected to have older patients with suboptimal treatment and risk stratification. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 19, 2020 Category: Cardiology Authors: Miguel Alejandro Rodr íguez-Ramos, Dayani Arteaga-Guerra, Michel Guillermo-Segredo, Leonel Simancas-Broche Tags: Short communication Source Type: research

Transition protocol from subcutaneous treprostinil to intravenous epoprostenol in deteriorating patients with pulmonary arterial hypertension
Despite advantages in the treatment options of pulmonary arterial hypertension, continuous parenteral prostanoid administration, although often complicated by serious side effects, remains the treatment of choice for patients with advanced disease. The need of transitioning from one parenteral prostanoid agent to the other is often faced in the daily clinical practise. Up to today, there is no established transition protocol from subcutaneous treprostinil to intravenous epoprostenol. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 19, 2020 Category: Cardiology Authors: Sophia Anastasia Mouratoglou, Anthoula Patsiala, Christos Feloukidis, Haralambos Karvounis, George Giannakoulas Tags: Short communication Source Type: research

Transcatheter aortic valve replacement with the balloon-expandable SAPIEN 3 valve: Impact of calcium score on valve performance and clinical outcomes
Aortic valve calcification severity has been associated with higher rates of aortic regurgitation (AR) following TAVR, but scarce data exist on its impact with the use of newer generation transcatheter heart valves. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 18, 2020 Category: Cardiology Authors: Leonardo Guimar ães, Alfredo Nunes Ferreira-Neto, Marina Urena, Luis Nombela-Franco, Jerome Wintzer-Wehekind, Marie-Helene Levesque, Dominique Himbert, Quentin Fischer, German Armijo, Rafael Vera, Dimitri Kalavrouziotis, Josep Rodés-Cabau Source Type: research

Microvascular function, diabetes and coronary risk
The coronary microcirculation is the major determinant of coronary blood flow in the absence of critical epicardial stenoses. For decades, microvascular dysfunction has been measured by means of coronary flow reserve (CFR) –that is, the ratio of hyperemic over baseline coronary flow– with a normal cutoff between 2.0 and 2.5. However, CFR has several shortcomings, such as depending on baseline coronary flow and not being completely specific of the microcirculation, but also affected by epicardial stenoses. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 18, 2020 Category: Cardiology Authors: Enrique Guti érrez Tags: Editorial Source Type: research

Electrocardiographic sex-related differences in patients with atrial fibrillation: Do they allow a better risk stratification?
Atrial fibrillation (AF) is the most common arrhythmia and is associated with increased morbidity and mortality. Its prevalence is increasing with the aging of the population and there is a clear need for more reliable diagnosis and improved therapy. Current therapeutic approaches for AF have only moderate efficacy, substantial side effects and eminent limitations due to the complex treatment of concomitant thromboembolism, cardiac ischemia and heart failure [1,2]. Sex-related differences in the prevalence, presentation, associated co-morbidities and therapy outcomes further complicate the management of this important clin...
Source: International Journal of Cardiology - February 18, 2020 Category: Cardiology Authors: Sotirios Nedios, Dobromir Dobrev Tags: Editorial Source Type: research

Corrigendum to “Assessment of myocardial tissue characterization in hypertension with left ventricular diastolic dysfunction” [Int. J. Cardiol., 297S (2019) 7–8]
The authors' names have been misspelled and put in the wrong order. The authors would like to apologise for any inconvenience caused. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 18, 2020 Category: Cardiology Authors: H.A. Zainal Abidin, H. Zhou, L. Arcari, C. Arendt, E. Nagel, V.O. Puntmann Tags: Corrigendum Source Type: research

Coronary anomalies in tetralogy of Fallot – A meta-analysis
An anomalous coronary artery is reported in 2% to 23% of patients with tetralogy of Fallot (TOF). Knowledge of coronary anatomy prior to corrective surgery is vital to avoid damage to vessels crossing the right ventricular outflow tract (RVOT). A meta-analysis on the prevalence of anomalous coronary arteries in TOF is lacking to date. Here, an overview of coronary anomalies in TOF is provided and implications for patient management are discussed. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 18, 2020 Category: Cardiology Authors: Claire J. Koppel, Monique R.M. Jongbloed, Philippine Ki ès, Mark G. Hazekamp, Bart J.A. Mertens, Martin J. Schalij, Hubert W. Vliegen Source Type: research

Temporal changes in left ventricular ejection fraction and their prognostic impacts in patients with Stage B heart failure
We have recently demonstrated that left ventricular ejection fraction (LVEF) dynamically changes over time with prognostic impacts in Stage C/D patients, namely, those who have a current or past history of heart failure (HF). However, it is unknown whether this is also the case in asymptomatic Stage B patients, namely, those who have a risk of HF, but do not have a history of HF. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 15, 2020 Category: Cardiology Authors: Hajime Aoyanagi, Kotaro Nochioka, Yasuhiko Sakata, Masanobu Miura, Takashi Shiroto, Ruri Abe, Shintaro Kasahara, Masayuki Sato, Takahide Fujihashi, Shinsuke Yamanaka, Hideka Hayashi, Koichiro Sugimura, Jun Takahashi, Satoshi Miyata, Hiroaki Shimokawa, CHA Source Type: research

Validation of the long-term prognostic capability of the SYNTAX score II in patients undergoing biodegradable polymer-based Sirolimus-eluting stents: 2-years outcomes from the PANDA III trial
This study aimed to assess the prognostic ability of SYNTAX (Synergy Between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery) Score II (SS-II) in LM and/or 3VD patients undergoing biodegradable polymer-based drug-eluting stents (BP-DES) in the multi-central randomized PANDA III trial. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 15, 2020 Category: Cardiology Authors: Ying Song, Changdong Guan, Xuebin Cao, Lei Qin, Yi Li, Zhanquan Li, Shaoping Nie, Shuang Hou, Min Zhang, Runlin Gao, Jinqing Yuan, Bo Xu, the PANDA III Investigators Source Type: research

Early cardio-renal interactions among apparently healthy individuals undergoing coronary CT
Previously we found that cardiac chambers' volumes correlate with estimated glomerular filtration rate (eGFR) of hospitalized patients. Currently we aimed to demonstrate this relation among apparently healthy individuals. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 15, 2020 Category: Cardiology Authors: Zach Rozenbaum, Lilian Atlan, Philippe Taieb, Tamar Shalmon, Shlomo Berliner, Yaron Arbel, Galit Aviram Source Type: research

Strain predicts left ventricular functional recovery after acute myocardial infarction with systolic dysfunction
Regional and global longitudinal strain (RLS-GLS) are considered reliable indexes of myocardial viability in chronic ischemic patients and prediction of left ventricular (LV) functional recovery after acute myocardial infarction (MI) with preserved left ventricular ejection fraction (LVEF). We tested in the present study whether RLS and GLS could also identify transmural extent of myocardial scar and predict LV functional recovery and remodeling in patients with reduced LVEF after acute MI. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 15, 2020 Category: Cardiology Authors: Ahmed Ben Driss, Caroline Ben Driss Lepage, Anis Sfaxi, Maher Hakim, Simon Elhadad, Jean Yves Tabet, Ahmed Salhi, Virginie Brandao Carreira, Madjid Hattab, Philippe Meurin, H élène Weber, Phalla Ou, Jean François Quignodon, Guillaume Jondeau, Jean Pier Source Type: research

Serpina3 in myocardial infarction
The letter to the editor regarding our manuscript “Circulating Serpina3 levels predict the major adverse cardiac events in patients with myocardial infarction” [1] raises insightful comments. We did not report molecular mechanisms of serpina3 in myocardial infarction, but the letter suggests one possible explanation. Long non-coding RNA (lncRNA ), a novel class of non-coding RNA, combine with biological molecules (e.g. miRNAs, proteins) and influence key signaling pathways in different pathophysiologic process [2]. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 15, 2020 Category: Cardiology Authors: Lei Zhao, Mulei Chen, Xinchun Yang Tags: Letter to the Editor Source Type: research

The convergent procedure versus catheter ablation alone in longstanding persistent atrial fibrillation: A single centre, propensity-matched cohort study
This study evaluates the safety and efficacy of the convergent procedure versus catheter ablation alone in longstanding PeAF. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 14, 2020 Category: Cardiology Authors: E. Maclean, J. Yap, B. Saberwal, S. Kolvekar, W. Lim, N. Wijesuriya, N. Papageorgiou, G. Dhillon, R.J. Hunter, M. Lowe, P. Lambiase, A. Chow, H. Abbas, R. Schilling, E. Rowland, S. Ahsan Source Type: research

Worsening of mitral regurgitation following transcatheter aortic valve replacement
Given candidates of transcatheter aortic valve replacement (TAVR) often have concomitant functional mitral regurgitation (MR) due to increased preload on left ventricle, how to manage peri-procedural MR is required for the successful TAVR. I congratulate Ben-Assa and colleagues for demonstrating that post-procedural significant MR (instead of pre-procedural) was associated with mortality and morbidity following TAVR [1]. Their findings would help us post-procedural risk stratification and might encourage us intervene to the post-procedural MR following TAVR. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 14, 2020 Category: Cardiology Authors: Teruhiko Imamura Source Type: research

Stroke in pulmonary hypertension: Is it predictable or preventable?
Dear Editor, (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 14, 2020 Category: Cardiology Authors: Lingdan Chen, Wenjun He, Fei Liu, Tao Wang Tags: Letter to the Editor Source Type: research

Should the distribution of valve lesion be considered in the autoimmune response of rheumatic heart disease?
Pathogenesis of rheumatic heart disease (RHD) has been investigated but the precise mechanism remains unclear, in addition to group A streptococcal infection, both genetic and environmental factors, as well as humoral and cellular autoimmune responses are involved in the development of RHD [1]. The recent study by Soares et al. reported the levels of imflammatory cytokines of CD4+ T cell subsets were associated with RHD severity [2], which could provide more evidence for the clinical risk stratification and development of individualized solution. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 14, 2020 Category: Cardiology Authors: Yue Zhong, Ying Peng, Li Rao Tags: Letter to the Editor Source Type: research

Editorial Board
(Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 14, 2020 Category: Cardiology Source Type: research

Long-term outcomes after second-generation cryoballoon ablation of paroxysmal atrial fibrillation – Feasibility of a single short freeze strategy without bonus applications
A paucity of data exists about long-term outcomes after second-generation cryoballoon ablation (2nd-CBA), and the feasibility of short freeze strategies remains under debate. We assessed the long-term follow-up outcomes. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 14, 2020 Category: Cardiology Authors: Satoshi Hara, Shinsuke Miyazaki, Hitoshi Hachiya, Takatsugu Kajiyama, Tomonori Watanabe, Hiroaki Nakamura, Hiroshi Tada, Yoshito Iesaka Source Type: research

National prevalence, trends and outcomes of takotsubo syndrome in hospitalizations with prior history of mediastinal/intrathoracic cancer and radiation therapy
Radiation therapy (RT) for cancers in thoracic/mediastinal region has been linked with heart damage following years of radiation exposure. However, prevalence of takotsubo syndrome (TTS) in patients with prior intrathoracic/mediastinal malignancies treated with RT has never been analyzed on a large scale. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 14, 2020 Category: Cardiology Authors: Rupak Desai, Aakash Desai, Shabber A. Abbas, Upenkumar Patel, Snehal Bansod, Nanush Damarlapally, Rajkumar Doshi, Sejal Savani, Kishorbhai Gangani, Rajesh Sachdeva, Gautam Kumar Tags: Short communication Source Type: research

Femoral transcatheter valve-in-valve implantation as alternative strategy for failed aortic bioprostheses: A single-centre experience with long-term follow-up
Surgical reoperation is still a standard procedure performed for degenerated aortic bioprostheses. On the other hand femoral minimally invasive valve-in-valve implantation (femTAVI-VIV) is an intriguing alternative. This clinical study was design to compare the early and late outcomes of redo-surgery (Redo-AVR) and femTAVI-VIV procedures for failed aortic bioprostheses. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 13, 2020 Category: Cardiology Authors: Tomasz Stankowski, Sleiman Sebastian Aboul-Hassan, Farzaneh Seifi-Zinab, Volker Herwig, Piotr St ępiński, Oliver Grimmig, Soeren Just, Axel Harnath, Anja Muehle, Dirk Fritzsche, Bartłomiej Perek Source Type: research

Identification of a pulmonary arterial hypertension (PAH) patient cohort and study of its burden of illness in Programme de M édicalisation des Systèmes d'information (PMSI)
Define a French PAH cohort using an evidence-based algorithm and describe its burden of disease in terms of healthcare resource use and costs. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 13, 2020 Category: Cardiology Authors: Fernando Exposto, Nicoleta Petric ă, Evan Davies, Amélie Beaudet Source Type: research

Acute myocardial infarction-cardiogenic shock in patients with prior coronary artery bypass grafting: A 16-year national cohort analysis of temporal trends, management and outcomes
There are limited data on the outcomes of acute myocardial infarction with cardiogenic shock (AMI-CS) in patients with prior coronary artery bypass grafting (CABG). (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 13, 2020 Category: Cardiology Authors: Saraschandra Vallabhajosyula, Vinayak Kumar, Saarwaani Vallabhajosyula, Anna V. Subramaniam, Sri Harsha Patlolla, Dhiran Verghese, Lina Ya'Qoub, John M. Stulak, Gurpreet S. Sandhu, Abhiram Prasad, David R. Holmes, Gregory W. Barsness Source Type: research

Left atrial appendage mechanical dispersion provides incremental value for thromboembolic risk stratification over CHA2DS2-VASc Score in nonvalvular atrial fibrillation
Left atrial appendage (LAA) dysfunction is associated with increased risk of thromboembolic events. However, little is known about LAA mechanical dispersion (MD) would provide additional information toward thromboembolism over the CHA2DS2-VASc score. The aim of this study was to determine the association of LAA mechanics as assessed by speckle-tracking imaging with thromboembolic events in patients with nonvalvular atrial fbrillation (AF). (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 13, 2020 Category: Cardiology Authors: Yankai Mao, Mingming Ma, Yuan Yang, Chan Yu, Yunhe Wang, Ruhong Jiang, Chenyang Jiang Source Type: research

Troponin elevation is very common in patients with infective endocarditis and is associated with a poor outcome
We sought to study the prevalence of cardiac troponin T (TnT) elevation in patients with infective endocarditis (IE) and its association with in-hospital outcomes. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 12, 2020 Category: Cardiology Authors: Andrea Postigo, Javier Bermejo, Patricia Mu ñoz, Maricela Valerio, Mercedes Marín, Blanca Pinilla, Gregorio Cuerpo, Amaia Marí, Antonia Delgado-Montero, Emilio Bouza, Francisco Fernández-Avilés, Manuel Martínez-Sellés Source Type: research

Is risk stratification with the Larissa Heart Failure Risk Score useful in Japanese acute heart failure patients?
Acute heart failure (AHF) is a growing worldwide medical problem with a higher in-hospital, post-discharge mortality, and rehospitalization rates. Despite recent advances in the management of AHF, the clinical outcomes of AHF are dismal, because AHF patients are getting sicker, older, and having more complicated comorbidities. Previous studies have shown that several clinical HF risk scores such as the BIOSTAT, SEATTLE-HF, APACHE-HF, ELAN-HF, OPTIMIZE-HF, ADHERE, ESCAPE scores have been developed and internal or external validated for in-hospital and post-discharge mortality in a large number of patients, but most of these...
Source: International Journal of Cardiology - February 12, 2020 Category: Cardiology Authors: Kyeong-Hyeon Chun, Seok-Min Kang Tags: Editorial Source Type: research

Left ventricular end-diastolic pressure and contrast-induced acute kidney injury: A new chapter of the cardio-renal saga
Contrast-induced acute kidney injury (CI-AKI) is a frequent complication of percutaneous coronary intervention (PCI), and has been linked to serious adverse events, including need for dialysis, permanent decline in renal function, and mortality [1]. As part of a strategy to minimize CI-AKI incidence, prompt identification of at-risk subjects is of paramount importance. This is based on validated risk scores [2 –4], which in turn rely on the recognition of CI-AKI risk factors (patient- and procedure-related variables) [1,5]. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 12, 2020 Category: Cardiology Authors: Lorenzo Azzalini Tags: Editorial Source Type: research

Diphosphonate single-photon emission computed tomography in cardiac transthyretin amyloidosis
Planar diphosphonate scintigraphy is an established diagnostic tool for amyloid transthyretin (ATTR) cardiomyopathy. Characterization of the amyloid burden up to the segmental level by single photon emission computed tomography (SPECT) has not been evaluated so far. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 11, 2020 Category: Cardiology Authors: Chrysanthos Grigoratos, Alberto Aimo, Claudio Rapezzi, Dario Genovesi, Andrea Barison, Giovanni Donato Aquaro, Giuseppe Vergaro, Angela Pucci, Claudio Passino, Paolo Marzullo, Alessia Gimelli, Michele Emdin Source Type: research

Risk of sudden cardiac death in New York Heart Association class I patients with dilated cardiomyopathy: A competing risk analysis
This study sought to assess the competing risk of sudden cardiac death (SCD) in DCM patients with left ventricular ejection fraction (EF) ≤35% and NYHA I class. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 10, 2020 Category: Cardiology Authors: Davide Stolfo, Stefano Albani, Gianluigi Savarese, Giulia Barbati, Federica Ramani, Marta Gigli, Federico Biondi, Matteo Dal Ferro, Massimo Zecchin, Marco Merlo, Gianfranco Sinagra Source Type: research

The extent and location of late gadolinium enhancement predict defibrillator shock and cardiac mortality in patients with non-ischaemic dilated cardiomyopathy
In non-ischaemic dilated cardiomyopathy (NIDCM), it is uncertain which late gadolinium enhancement (LGE) pattern, extent and location predict ventricular arrhythmias. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 10, 2020 Category: Cardiology Authors: Andrea Barison, Alberto Aimo, Gianluca Mirizzi, Vincenzo Castiglione, Andrea Ripoli, Luca Panchetti, Andrea Rossi, Alberto Giannoni, Umberto Startari, Giovanni Donato Aquaro, Michele Emdin, Marcello Piacenti Source Type: research

Short-term effects of low-dose tolvaptan in acute decompensated heart failure patients with severe aortic stenosis: The LOHAS registry
This study aimed to evaluate the short-term effects of tolvaptan in ADHF patients with severe AS. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 7, 2020 Category: Cardiology Authors: Yusuke Watanabe, Yugo Nara, Hirofumi Hioki, Hideyuki Kawashima, Akihisa Kataoka, Makoto Nakashima, Yosuke Nishihata, Kentaro Hayashida, Masanori Yamamoto, Jun Tanaka, Kazuki Mizutani, Kentaro Jujo, Gaku Nakazawa, Masaki Izumo, Ken Kozuma Source Type: research

Innovators in atherosclerosis research: A historical review
This review presents a retrospective analysis of the significance of the contributions of pathologists and kindred investigators in the latter half of the twentieth century to the advancement of understanding of atherosclerosis, a major disease and affliction of humankind. These outstanding investigators contributed importantly to the development of a large body of evidence encompassing population-based autopsy studies, experimental animal studies and cell biological investigations that, coupled with insights from epidemiological studies, serve as the underpinning for the current dominant response to injury theory of ather...
Source: International Journal of Cardiology - February 7, 2020 Category: Cardiology Authors: L. Maximilian Buja Source Type: research

Risk of de-novo heart failure and competing risk in asymptomatic patients with structural heart diseases
Asymptomatic patients with structural heart diseases are classified as a population at high risk for heart failure (HF) in Stage B. However, limited data are available regarding incidence and related factors of de-novo HF (DNHF) considering competing risk in this population. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 6, 2020 Category: Cardiology Authors: Tsuyoshi Takada, Yasuhiko Sakata, Kotaro Nochioka, Masanobu Miura, Ruri Abe, Shintaro Kasahara, Masayuki Sato, Hajime Aoyanagi, Takahide Fujihashi, Shinsuke Yamanaka, Kota Suzuki, Takashi Shiroto, Koichiro Sugimura, Jun Takahashi, Satoshi Miyata, Hiroaki Source Type: research