Fluid-filled versus sensor-tipped pressure guidewires for FFR and Pd/Pa measurement; PW-COMPARE study
This study aimed to compare simultaneous pressure measurements with fluid-filled and sensor-tipped pressure guidewires. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - March 28, 2024 Category: Cardiology Authors: Rob Eerdekens, Pim A.L. Tonino, Frederik M. Zimmermann, Koen Teeuwen, Pieter-Jan Vlaar, Guus A. de Waard, Niels van Royen, Lokien X. van Nunen Source Type: research

Temporal progression of replacement and interstitial fibrosis in optimally managed dilated cardiomyopathy patients: A prospective study
Background: To prospectively examine the dynamic evolution of fibrotic processes within a one-year in patients with dilated cardiomyopathy (DCM). Methods: Between May 2019 and September 2020, 102 DCM patients (mean age 45.2  ± 11.8 years, EF 29.9 ± 11.6%) underwent cardiac magnetic resonance (CMR-1). After 13.9 ± 2.9 months, 92 of these patients underwent a follow-up CMR (CMR-2). Replacement fibrosis was assessed via late gadolinium enhancement (LGE), quantified in terms of LGE mass and extent. Inter stitial fibrosis was evaluated via T1-mapping and expressed as extracellular volume fraction (ECV). (Sour...
Source: International Journal of Cardiology - March 26, 2024 Category: Cardiology Authors: Pawel Rubi ś, Paweł Banyś, Maciej Krupiński, Małgorzata Mielnik, Sylwia Wiśniowska-Śmiałek, Ewa Dziewięcka, Małgorzata Urbańczyk-Zawadzka Source Type: research

Comment on “Subclinical myocardial injury increases the risk of heart failure in patients with and without type 2 diabetes post-acute coronary syndrome”
In this study, 50 acute coronary syndrome (ACS) patients who underwent revascularization were prospectively enrolled, and the univariate analysis was used for the evaluation of the effect of subclinical myocardial injury (sMi) on heart failure risk after ACS. They found and concluded that the sMi increased the risk of heart failure after ACS, irrespective of diabetes status. However, we raise some statistical concerns which could change the conclusion of this study. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - March 23, 2024 Category: Cardiology Authors: Yun Cheng, Qinggang Zhang Source Type: research

Machine learning to identify a composite indicator to predict cardiac death in ischemic heart disease
Machine learning (ML) employs algorithms that learn from data, building models with the potential to predict events by aggregating a large number of variables and assessing their complex interactions. The aim of this study is to assess ML potential in identifying patients with ischemic heart disease (IHD) at high risk of cardiac death (CD). (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - March 23, 2024 Category: Cardiology Authors: Alessandro Pingitore, Chenxiang Zhang, Cristina Vassalle, Paolo Ferragina, Patrizia Landi, Francesca Mastorci, Rosa Sicari, Alessandro Tommasi, Cesare Zavattari, Giuseppe Prencipe, Alina S îrbu Source Type: research

Enhancing walking performance in patients with peripheral arterial disease: An intervention with ankle-foot orthosis
This study aimed to employ advanced biomechanical gait analysis to evaluate the impact of AFO intervention on gait performance among patients with PAD. Patients with claudication had hip, knee, and ankle joint kinetics and kinematics assessed using a cross-over intervention design. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - March 23, 2024 Category: Cardiology Authors: Farahnaz Fallahtafti, Kaeli Samson, Zahra Salamifar, Jason Johanning, Iraklis Pipinos, Sara A. Myers Source Type: research

Advancing precision medicine in INOCA research: The INOCA-IT registry
Ischemia with non-obstructive coronary artery disease (INOCA) poses a significant challenge in cardiovascular medicine, characterized by debilitating symptoms despite the absence of significant coronary artery stenoses [1]. In this issue of the International Journal of Cardiology, Ghizzoni et al. [2] present the rationale and design of the INOCA-IT Multicenter Registry, offering a promising avenue for patients and clinicians navigating this complex condition. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - March 21, 2024 Category: Cardiology Authors: Johanna McChord, Peter Ong Source Type: research

Development and validation of a novel score for predicting perioperative major adverse cardiovascular events in patients with stable coronary artery disease undergoing noncardiac surgery
A model developed specifically for stable coronary artery disease (SCAD) patients to predict perioperative major adverse cardiovascular events (MACE) has not been previously reported. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - March 21, 2024 Category: Cardiology Authors: Yunpeng Jin, Liang Shen, Runze Ye, Min Zhou, Xiaogang Guo Source Type: research

Quantification of ventricular stress in univentricular hearts during early childhood using age-independent zlog-NT-proBNP
Children with univentricular hearts (UVH) undergo up to three palliative surgical procedures to achieve complete circulatory separation (Fontan circulation). As a marker of cardiac wall stress, NT-proBNP is a promising tool to assess systemic ventricular load in these patients. However, different reference intervals (RI) apply to each stage, as NT-proBNP is highly age-dependent. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - March 21, 2024 Category: Cardiology Authors: Jonas Palm, Masamichi Ono, Carolin Niedermaier, J ürgen Hörer, Georg Hoffmann, Stefan Holdenrieder, Frank Klawonn, Peter Ewert Source Type: research

The miR-195-3p/BDNF axis is a promising therapeutic for heart failure
Dear Editor, (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - March 21, 2024 Category: Cardiology Authors: Luyuan Yao, Xiaofang Gong, Yongpan Liu, Kun Hao, Jinlong Jiang, Zhihuan Luo Source Type: research

Prognosis of anemic patients with atrial fibrillation undergoing percutaneous coronary intervention
There are limited data regarding whether anemia is associated with adverse clinical outcomes in patients with atrial fibrillation (AF) after percutaneous coronary intervention (PCI). (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - March 21, 2024 Category: Cardiology Authors: Kaori Abe, Hideki Kitahara, Sakuramaru Suzuki, Takashi Hiraga, Tatsuro Yamazaki, Yuji Ohno, Junya Harada, Kenichi Fukushima, Tatsuhiko Asano, Naoki Ishio, Raita Uchiyama, Hirofumi Miyahara, Shinichi Okino, Masanori Sano, Nehiro Kuriyama, Masashi Yamamoto, Source Type: research

Combined polygenic scores for ischemic stroke risk factors aid risk assessment of ischemic stroke
Current risk assessment for ischemic stroke (IS) is limited to clinical variables. We hypothesize that polygenic scores (PGS) of IS (PGSIS) and IS-associated diseases such as atrial fibrillation (AF), venous thromboembolism (VTE), coronary artery disease (CAD), hypertension (HTN), and Type 2 diabetes (T2D) may improve the performance of IS risk assessment. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - March 21, 2024 Category: Cardiology Authors: Sarah Huang, Abhishek Joshi, Zhuqing Shi, Jun Wei, Huy Tran, S. Lilly Zheng, David Duggan, Annabelle Ashworth, Liana Billings, Brian T. Helfand, Arman Qamar, Zachary Bulwa, Alfonso Tafur, Jianfeng Xu Source Type: research

Pulsed field ablation: A promising approach for ventricular tachycardia ablation
Radiofrequency ablation (RFA) has been a central therapeutic strategy for ventricular tachycardia (VT). However, concerns about its long-term effectiveness and complications have arisen. Pulsed field ablation (PFA), characterized by its nonthermal, highly tissue-selective ablation technique, has emerged as a promising alternative. This comprehensive review delves into the potential advantages and opportunities presented by PFA in the realm of VT, drawing insights from both animal experimentation and clinical case studies. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - March 19, 2024 Category: Cardiology Authors: Zixi Zhang, Yichao Xiao, Cancan Wang, Jiabao Zhou, Qiuzhen Lin, Tao Tu, Keke Wu, Yunying Huang, Zeying Zhang, Chan Liu, Qiming Liu Source Type: research

ST Elevation is a poor surrogate for acute coronary occlusion. Let's Replace STEMI with Occlusion MI (OMI)!!
In this issue of the IJC, de Alencar Neto et al. publish a well done meta-analysis of all studies (total of 3) which report the sensitivity of ST Elevation (STE) criteria for angiographic Acute Coronary Occlusion MI (ACOMI, or OMI), and found that the pooled sensitivity was only 43.6%, in spite of the fact that it is generally taken for granted that STE is an adequate surrogate for OMI [1]. That the STEMI/NonSTEMI dichotomy has been in use for over 20  years without angiographic data on its validity is shocking. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - March 19, 2024 Category: Cardiology Authors: Stephen W. Smith, H. Pendell Meyers Source Type: research

Role of interleukin 6 signaling pathway in the anti-inflammatory effects of statins on coronary artery disease: Evidence from Mendelian randomization analysis
Statins are currently widely used in the prevention of coronary artery disease (CAD) primarily for lipid-lowering with a potential anti-inflammatory effect. However, it is not clear if their potential anti-inflammatory effects are mediated through the interleukin 6 (IL-6) signaling pathway. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - March 19, 2024 Category: Cardiology Authors: Mojgan Yazdanpanah, Nahid Yazdanpanah, Mojtaba Chardoli, Abbas Dehghan Source Type: research

Response to: Regard to assessing agreement between two raters with kappa statistics
We thank Dr. Yu et al. for their interest in our manuscript. As the authors state, there are a variety of statistical methods that may be used to assess inter-operator agreement – in this case between the Risk-SCD and ACC/AHA scores used to stratify risk of sudden cardiac arrest in hypertrophic cardiomyopathy (HCM) [1]. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - March 19, 2024 Category: Cardiology Authors: Elizabeth D. Paratz, Dion Stub, Nigel Sutherland, Sarah Gutman, Andre La Gerche, Justin Mariani, Andrew Taylor, Andris Ellims Source Type: research