International Journal of Cardiology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Lactate load in acute myocardial infarction: Old but gold?
Healthcare systems have recognized and understood the improvements granted by early recognition of dangerous courses in diseases often encountered in the general population and with a possible volatile development. For these diseases, searching for the one accurate biomarker to predict an adverse outcome might revolutionize diagnosis and treatment and represent a tip of current clinical research. Acute myocardial infarction (AMI), a condition where the myocardium is deprived of perfusion and oxygen supply, is often encountered in older individuals and is one of the main reasons for death worldwide. (Source: International J...
Source: International Journal of Cardiology - January 9, 2024 Category: Cardiology Authors: Dragos Andrei Duse, Malte Kelm, Ralf Erkens Tags: Editorial Source Type: research

Myocardial work and left heart deformation parameters across primary mitral regurgitation severity
Myocardial work (MW) estimation by pressure-strain loops using speckle tracking echocardiography (STE) has shown to evaluate left ventricular (LV) contraction overcoming the load-dependency limit of LV global longitudinal strain (GLS). This has proved useful hemodynamic variation settings e.g. heart failure and valvular heart disease. However, the variation of MW and strain parameters across different stages of primary mitral regurgitation (MR) and its impact on symptoms, which was the aim of our study, has never been investigated. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - January 9, 2024 Category: Cardiology Authors: Maria Concetta Pastore, Francesca Vannuccini, Giulia Elena Mandoli, Matteo Lisi, Maria Alma Iuliano, Alfonso Santoro, Francesco Paolo Niglio, Enrico Emilio Diviggiano, Veronica Lorenz, Gianfranco Montesi, Luna Cavigli, Marta Focardi, Flavio D'Ascenzi, Mat Source Type: research

A V-shaped association between high-density lipoprotein cholesterol levels and poor outcomes in patients after percutaneous coronary intervention
High density lipoprotein cholesterol (HDLC) is considered as “good cholesterol”. Recent evidence suggests that a high HDL-C level may increase the risk of poor outcomes in some populations. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - January 9, 2024 Category: Cardiology Authors: Xiao-Fang Chen, Yi-Fei Xiang, Xiao-Ling Cai, Jun-Han Chen, Xue-Qin Lin, Bi-Ting Lin, Wen-Jia Liang, Geng-Yu Zhou, Yan-Song Guo, Kai-Yang Lin Source Type: research

A comprehensive guide on the optimal timing of PCI in the setting of acute coronary syndrome: An updated meta-analysis
Invasive revascularization is recommended for cohorts of patients with ST-elevation myocardial infarction (STEMI) and non-ST-elevation acute coronary syndrome (NSTE-ACS). However, the optimal timing of invasive revascularization is still controversial and no defined consensus is established. We aim to give a comprehensive appraisal on the optimal timing of invasive strategy in the heterogenous population of ACS. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - January 9, 2024 Category: Cardiology Authors: Ahmed Abdelaziz, Hanaa Elsayed, Karim Atta, Ahmed Mechi, Hallas Kadhim, Aya Moustafa Aboutaleb, Ahmed Elaraby, Mohamed Hatem Ellabban, Mahmoud Eid, Hadeer Elsaeed AboElfarh, Rahma AbdElfattah Ibrahim, Emad Addin Zawaneh, Mahmoud Ezzat, Mohamed Abdelaziz, Source Type: research

The impact of early in-hospital use of PCSK9 inhibitors on cardiovascular outcomes in acute coronary syndrome patients: A systematic review and meta-analysis
To explore the safety and assess the cardiovascular impact of early in-hospital administration of PCSK9 inhibitors in patients with acute coronary syndrome (ACS). (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - January 9, 2024 Category: Cardiology Authors: Deng Yifan, Ma Yue, Zhang Yubin, Gao Jiapei, Sun Xu, He Shenghu, Zhu Li, Zhang Jing Source Type: research

Performance of a non-irrigated bipolar radiofrequency ablation clamp on beating human hearts
This study is intended to examine the efficacy of a non-irrigated bipolar RF clamp and explore the factors that can influence its performance on beating human hearts using the electrophysiology mapping method. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - January 8, 2024 Category: Cardiology Authors: Fan Weng, Tao Yan, Miao Zhu, Shijie Zhu, Kai Zhu, Chunsheng Wang, Zongliang Zhao, Changfa Guo Source Type: research

Reply to “Loganin: A potential pharmacological agent for myocardial ischemia-reperfusion injury”
Our recent work published in the International Journal of Cardiology suggests that loganin treatment inhibits oxidative stress and cellular apoptosis in myocardial ischemia-reperfusion injury (MIRI) in part via Janus kinase 2 (JAK2)/Signal Transducer and Activator of Transcription 3 (STAT3) [1]. We greatly appreciate the comments of Li et al. suggesting that the anti-inflammatory property of loganin may also explain its protective effect against MIRI. We agree with this view, because our follow-up experiments showed that loganin significantly altered the expression of interleukin-10 (IL-10) in the ischemic area of the left...
Source: International Journal of Cardiology - January 6, 2024 Category: Cardiology Authors: Boyu Xia, Jiaqi Ding, Qi Li, Koulong Zheng, Jingjing Wu, Chao Huang, Kun Liu, Qingsheng You, Xiaomei Yuan Tags: Letter to the Editor Source Type: research

Response to: “Evolut R and Evolut PRO vs. Sapien 3 for transcatheter aortic valve implantation – The ‘generation gap’ and beyond”
We appreciate the commentary by Miros ław Gozdek and Mariusz Kowalewski on our meta-analysis. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - January 4, 2024 Category: Cardiology Authors: Tsahi T. Lerman, Amos Levi, Ran Kornowski Tags: Letter to the Editor Source Type: research

Letter to the editor: Clinical evaluation of Sepsis-1 and Sepsis-3 in infective endocarditis
This study reported the Sepsis-3 criteria were independently associated with both in-hospital and 6-month mortality among patients with IE. In contrast, the Sepsis-1 criteria did not demonstrate a similar association with the in-hospital and 6-month mortality in these patients. Moreover, the Sequential Organ Failure Assessment (SOFA) score exhibited greater discriminative ability compared to the Systemic Inflammatory Response Syndrome (SIRS) criteria in accurately predicting in-hospital mortality in IE patients.However, we would like to add a few more points concerning the study's validity [1]. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - January 4, 2024 Category: Cardiology Authors: Xi Li, Tao Yu, Jin Tan Tags: Letter to the Editor Source Type: research

Effect of six month's treatment with omega-3 acid ethyl esters on long-term outcomes after acute myocardial infarction: The OMEGA-REMODEL randomized clinical trial
Omega-3 polyunsaturated fatty acids (O3-FA) have been shown to reduce inflammation and adverse cardiac remodeling after acute myocardial infarction (AMI). However, the impact O3FA on long-term clinical outcomes remains uncertain. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - January 3, 2024 Category: Cardiology Authors: Benedikt Bernhard, Bobak Heydari, Shuaib Abdullah, Sanjeev A. Francis, Heidi Lumish, Wei Wang, Michael Jerosch-Herold, William S. Harris, Raymond Y. Kwong Source Type: research

AAV vectors advance cardiac gene therapy while overcoming challenges.
The idea of gene therapy, in which nucleic acids are introduced into cells to restore lost functions, was proposed in the 1970s with the progress of molecular biology [1]. Development has focused on methods to replenish genes by expressing normal cDNAs of damaged genes in cells, but there are also methods to express miRNAs and shRNAs that suppress the expression of harmful genes. Recently, genome editing technologies have also started to be applied clinically. In the last decade, gene therapy developments have increased exponentially, with more than 2000 in the development pipeline, including targeting cardiovascular and m...
Source: International Journal of Cardiology - January 3, 2024 Category: Cardiology Authors: Shin-ichi Muramatsu Tags: Editorial Source Type: research

Reply to: Supported PCI reduced one-year all-cause mortality compared to standard PCI?
I would like to congratulate the authors for their precise research letter entitled: “supported PCI reduced one-year all-cause mortality compared to standard PCI?”. The authors should be acknowledged for their concise and timely work in trying to underline the problem of consistency in meta-analysis that consider also non RCTs evidence. Their comment is appropriate and clear. Ne vertheless, some observations must be addressed, and some issues must be taken in consideration in the case of the study from Iannaccone et al., especially regarding the choice between fixed and random effect in pair-wise meta-analysis, a field...
Source: International Journal of Cardiology - January 3, 2024 Category: Cardiology Authors: Mario Iannaccone, Luca Franchin Tags: Letter to the Editor Source Type: research

Patients with surgically repaired ASD in childhood: living happily ever after?
It has been over 30  years since the publication of the first comprehensive cohort study of patients with surgical repair of atrial septal defects (ASD) [1]. In the renowned study from the Mayo Clinic, individuals with ASD repaired at a pediatric age demonstrated an overall positive outcome, with low mortality rates and a reduced incidence of supraventricular arrhythmias at 30 years in comparison to those operated later in life. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - January 3, 2024 Category: Cardiology Authors: V. Gonz ález-Fernández, L. Dos-Subirà Tags: Editorial Source Type: research

Circulating biomarkers of the CS4P and CLIP scores are not altered in a pig model of acute cardiogenic shock and additional short-term circulatory support
Cardiogenic shock (CS) is the leading cause of death in patients with myocardial infarction with a mortality rate>50%. Recently, the CS 4 Proteins (CS4P) and CLIP scores have been developed to predict survival in CS patients. However, their impact in acute CS and additional short-term left ventricular (LV) circulatory support as prognostic markers remains to be determined. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - January 2, 2024 Category: Cardiology Authors: Christian Riehle, Jan-Thorben Sieweke, Nanna Louise Junker Udesen, Ole K.L. Helgestad, Natali Froese, Hanne Berg Ravn, Ralf Lichtinghagen, Jacob E. M øller, Johann Bauersachs, Andreas Schäfer Tags: Short communication Source Type: research

A novel genetically engineered mouse model for investigating heart failure mechanisms and therapeutic interventions
Heart failure is a critical and challenging health issue that is the end-stage manifestation of many heart diseases with high mortality rates [1]. The urgent need to address this global health burden has prompted efforts to develop animal models for heart failure research [2]. In the new publication by Li et al., the authors present a novel approach targeting the dopamine D5 receptor in a cardiac-specific manner to induce stable and heritable heart failure in mice [3]. The authors convincingly argue that the limitations of existing experimental models emphasize the need for one that accurately reflects the gradual progress...
Source: International Journal of Cardiology - January 2, 2024 Category: Cardiology Authors: Toru Miyoshi Tags: Editorial Source Type: research