A novel genetically engineered mouse model for investigating heart failure mechanisms and therapeutic interventions

Heart failure is a critical and challenging health issue that is the end-stage manifestation of many heart diseases with high mortality rates [1]. The urgent need to address this global health burden has prompted efforts to develop animal models for heart failure research [2]. In the new publication by Li et al., the authors present a novel approach targeting the dopamine D5 receptor in a cardiac-specific manner to induce stable and heritable heart failure in mice [3]. The authors convincingly argue that the limitations of existing experimental models emphasize the need for one that accurately reflects the gradual progression of human heart failure.
Source: International Journal of Cardiology - Category: Cardiology Authors: Tags: Editorial Source Type: research