Aucubin protects against myocardial ischemia-reperfusion injury by regulating STAT3/NF- κB/HMGB-1 pathway
The objective of this research was to investigate if AU treatment could mitigate myocardial inflammation and apoptosis caused by ischemia/reperfusion (I/R) in both laboratory and animal models, and to elucidate its underlying mechanism. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - January 18, 2024 Category: Cardiology Authors: Yanwu Liu, Xian Cheng, Bingcai Qi, Yuchao Wang, Yue Zheng, Xiaoyu Liang, Yun Chang, Meng Ning, Wenqing Gao, Tong Li Source Type: research

For the management of protein-losing enteropathy, Gut-heart-relation in patients with Fontan circulation
Protein-losing enteropathy, PLE, is the abnormal loss of serum proteins into the intestinal lumen. It occurs in 5% to 12% of individuals after Fontan palliation, described as early as 1980 by Crupi et al. (1), followed by the first multicentre study published in 1998 by Mertens et al. [1]. Although Survival among those with PLE has improved from 50% to 88% at 5  years with improved treatment strategies in the current era [2], morbidity after diagnosis remains high [3]. Morbidity has been associated with higher pressure of the Fontan route, higher pulmonary vascular resistance, decreased ventricular function, lower cardia...
Source: International Journal of Cardiology - January 18, 2024 Category: Cardiology Authors: Yusuke Yumita, Koichiro Niwa Tags: Editorial Source Type: research

Clozapine metabolism and cardiotoxicity: A prospective longitudinal study
Clozapine-induced myocarditis and cardiomyopathy are difficult to detect clinically and may be fatal if not detected early. The current/routine biomarkers for clozapine-induced myocarditis are non-specific indicators of inflammation (C-reactive protein) or cardiomyocyte damage (troponins I and T) that lack sensitivity, and for which changes often arise too late to be clinically useful. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - January 18, 2024 Category: Cardiology Authors: Brandi L. Bellissima, Kathryn E. Burns, Nuala A. Helsby, Ellen L. Kingston, Fintan Garavan, Malcom D. Tingle Source Type: research

Adiponectin/leptin ratio predicts the remission of metabolic syndrome: A pilot study
Adipokines are key mediators of inflammation in metabolic syndrome perpetuating the effect of excess nutrient intake by setting a self-maintaining vicious circle. Here, we assess levels of adiponectin and leptin in a cohort of individuals with MetS undergoing dietary and behavioral counselling. Specifically, we investigate their role as predictors of metabolic syndrome remission after 1  year. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - January 17, 2024 Category: Cardiology Authors: Luca Liberale, Federico Carbone, Aldo Bonaventura, Simon Kraler, Maria Bertolotto, Nathan Artom, Roberto Pontremoli, Francesca C. Viazzi, Aldo Pende, Livia Pisciotta, Fabrizio Montecucco Tags: Short communication Source Type: research

Clinical characteristics and outcome of end stage hypertrophic cardiomyopathy: Role of age and heart failure phenotypes
A minority of patients with hypertrophic cardiomyopathy (HCM) presents advanced heart failure (HF) during their clinical course, in the context of left ventricular (LV) remodeling with reduced LV ejection fraction (LVEF), or of severe diastolic dysfunction without impaired LVEF. Aim of this study was to describe a multicentric end stage (ES) HCM population and analyze clinical course and outcome among its different phenotypes. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - January 17, 2024 Category: Cardiology Authors: Beatrice Musumeci, Giacomo Tini, Elena Biagini, Marco Merlo, Chiara Calore, Enrico Ammirati, Mattia Zampieri, Domitilla Russo, Giulia Grilli, Caterina Santolamazza, Riccardo Vio, Marta Rubino, Raffaello Ditaranto, Annamaria Del Franco, Paola Sormani, Vand Source Type: research

S-100 β level is closely associated with myocardial work in patients with acute ischemic stroke
This study aimed to determine the relationship between myocardial work and S100 β, a quantitative biomarker of active cerebral lesions, in patients with acute ischemic stroke (AIS). (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - January 17, 2024 Category: Cardiology Authors: Ran Cao, Lijuan Zhang, Xiaozhi Zheng Source Type: research

Predictors of prolonged hospital stay and in-hospital mortality in female patients with acute myocardial infarction with specific reference to diabetes
This study aimed to determine predictors of prolonged length of stay (LOS) and mortality in female STEMI patients with diabetes in comparison to female STEMI patients without diabetes. This retrospective single-center study was conducted between 2015 and 2020 as part of the STEMI registry in our center and included all STEMI patients. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - January 17, 2024 Category: Cardiology Authors: Ghada Shalaby, Sameh Sabri, Asma Nabat Safar Alsilami, Reem Yousef Alhassani, Suha Hashem Alsayed, Mohannd Amin Wasel Alhazmi, Mohamed Thabet Aoudallah, Sheeren Khaled Source Type: research

Comparative efficacy of vericiguat to sacubitril/valsartan for patients with heart failure reduced ejection fraction: Systematic review and network meta-analysis
This study aimed to assess the relative efficacy of vericiguat and sacubitril/valsartan through a systematic review, network meta-analysis, and non-inferiority tests. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - January 17, 2024 Category: Cardiology Authors: Dong-Won Kang, Seung-Ho Kang, Kyungmin Lee, Kyungae Nam, Eui-Soon Kim, Jong-Chan Yoon, Sun-Kyeong Park Source Type: research

Impact of concomitant surgical interventions on outcomes of septal myectomy in obstructive hypertrophic cardiomyopathy
Septal myectomy (SM) is offered to symptomatic patients with obstructive hypertrophic cardiomyopathy (oHCM) despite medical therapy. Frequently, patients undergo concomitant planned or ad-hoc mitral valve replacement (MVR), aortic valve replacement (SAVR), or coronary artery bypass grafting (CABG). (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - January 17, 2024 Category: Cardiology Authors: Ahmed M. Altibi, Abharika Sapru, Fares Ghanem, Yuanzi Zhao, Ahmad Alani, Joaquin Cigarroa, Babak Nazer, Howard K. Song, Ahmad Masri Source Type: research

Changes in walking speed 6  months after discharge may be more sensitive to subsequent prognosis than handgrip strength in patients hospitalized for heart failure
This study aimed to examine the association between changes after discharge and the subsequent prognosis. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - January 11, 2024 Category: Cardiology Authors: Satoru Hanada, Takuji Adachi, Kotaro Iwatsu, Kenta Kamisaka, Kuniyasu Kamiya, Sumio Yamada, On behalf of the FLAGSHIP collaborators Source Type: research

Role of genetics in inflammatory cardiomyopathy
Traditional cardiomyopathy paradigms segregate inflammatory etiologies from those caused by genetic variants. An identified or presumed trigger is implicated in acute myocarditis or chronic inflammatory cardiomyopathy but growing evidence suggests a significant proportion of patients have an underlying cardiomyopathy-associated genetic variant often even when a clear inflammatory trigger is identified. Recognizing a possible genetic contribution to inflammatory cardiomyopathy may have major downstream implications for both the patient and family. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - January 11, 2024 Category: Cardiology Authors: Paul J. Scheel, Iside Cartella, Brittney Murray, Nisha A. Gilotra, Enrico Ammirati Source Type: research

Changes in walking speed 6  months after discharge may be more sensitive to subsequent prognosis than handgrip strength in patients hospitalized for heart failure
This study aimed to examine the association between changes after discharge and the subsequent prognosis. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - January 11, 2024 Category: Cardiology Authors: Satoru Hanada, Takuji Adachi, Kotaro Iwatsu, Kenta Kamisaka, Kuniyasu Kamiya, Sumio Yamada, On behalf of the FLAGSHIP collaborators Source Type: research

Relationship between hyperuricemia and the risk of cardiovascular events and chronic kidney disease in both the general population and hypertensive patients: A systematic review and meta-analysis
To explore the relationships between hyperuricemia and the risk of cardiovascular diseases (CVD) and chronic kidney disease (CKD) in both the general population and hypertensive patients through meta-analysis. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - January 11, 2024 Category: Cardiology Authors: Li Zheng, Yue Zhu, Yuhan Ma, Honghong Zhang, Haijing Zhao, Yingyue Zhang, Zeng ’ao Yang, Yuqi Liu Source Type: research

Intermediate monocytes are associated with the first major adverse cardiovascular event in patients with stable coronary artery disease
Traditional risk stratification modestly predicts adverse cardiovascular events in patients with coronary artery disease (CAD). Our aim was to investigate the association between monocyte subsets numbers and function, and the first major adverse cardiovascular event (MACE) in patients with symptomatic stable CAD and angiographically documented coronary atherosclerosis. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - January 11, 2024 Category: Cardiology Authors: Mihaela I. Dregoesc, Adrian B. Țigu, Siroon Bekkering, Charlotte D.C.C. van der Heijden, Laura Rodwell, Sorana D. Bolboacă, Leo A.B. Joosten, Mihai G. Netea, Niels P. Riksen, Adrian C. Iancu Source Type: research

Global left ventricular myocardial work index and medium-term adverse cardiovascular events after ST-elevation myocardial infarction
Left ventricular global longitudinal strain (GLS) has incremental prognostic value over ejection fraction (EF) in patients with ST-segment-elevation myocardial infarction (STEMI), but it is also load dependent. It has been recently demonstrated that Myocardial work (MW), integrating blood pressure with GLS, predicts long-term all-cause mortality. We aimed to further explore the prognostic value of MW for cardiovascular endpoints in patients with STEMI. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - January 11, 2024 Category: Cardiology Authors: Ana Teresa Tim óteo, Luísa Moura Branco, Ana Galrinho, Pedro Rio, Ana Luísa Papoila, Marta Alves, Rui Cruz Ferreira Source Type: research