LKB1 inhibits the phenotypic transformation of vascular smooth muscle cells by activating SIRT6

Most recently, Chen et al. reported that vascular smooth muscle cell (VSMC)-specific overexpression of LKB1 in atherosclerotic mice inhibited the phenotypic transition of VSMCs and alleviated lipid accumulation within plaques, leading to the mitigation of atherogenesis [1]. This finding demonstrates the critical role of LKB1 in the phenotypic transformation of VSMCs and atherosclerosis, whereas the underlying mechanisms need further investigation.

Source: International Journal of Cardiology - April 24, 2024 Category: Cardiology Authors: Lin Zhu, Yu-Ping Wang, Xiao-Dan Xu, Xi Xu, Fu-Rong Shao, Kun Ren Source Type: research