Diagnostic value of LGE and T1 mapping in multiple myeloma patients ’heart
Unidentified heart failure occurs in patients with multiple myeloma when their heart was involved. CMR with late gadolinium enhancement (LGE) and T1 mapping can identify myocardial amyloid infiltrations. (Source: BMC Cardiovascular Disorders)
Source: BMC Cardiovascular Disorders - April 27, 2024 Category: Cardiology Authors: Qian Cui, Jing Yu, Xihong Ge, Guangfeng Gao, Yang Liu, Qiang He and Wen Shen Tags: Research Source Type: research
Immunological Aspects of Kabuki Syndrome: A Retrospective Multicenter Study of the Italian Primary Immunodeficiency Network (IPINet)
In conclusion, immunological manifestations of KS in our cohort include susceptibility to infections, antibody deficiency, and autoimmunity. Autoimmune cytopenia is correlated with thymectomy and elevated CD3 + TCRαβ + CD4-CD8-T-cells, and benefits from treatment with mycophenolate. (Source: Journal of Clinical Immunology)
Source: Journal of Clinical Immunology - April 27, 2024 Category: Allergy & Immunology Source Type: research
Unlocking the potential: Baicalin's apoptosis-reducing power and activation of NRF2/P62 for alleviating diabetic cardiomyopathy in rats
ConclusionBaicalin may reduce the effects of DCM by activating NRF2 through KEAP1 suppression and regulating autophagy activation. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - April 27, 2024 Category: Cytology Source Type: research
Associations between non-insulin-based insulin resistance indices and heart failure prevalence in overweight/obesity adults without diabetes mellitus: evidence from the NHANES 2001 –2018
The triglyceride glucose (TyG) index and triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio are recognized as simple non-insulin-based insulin resistance indices. Our study aimed to explore ... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - April 27, 2024 Category: Lipidology Authors: Di-yu Cui, Chao Zhang, Yi Chen, Gang-zhen Qian, Wan-xiang Zheng, Zhi-hui Zhang, Yu Zhang and Ping Zhu Tags: Research Source Type: research
Mitral valve surgery in patients with Marfan syndrome
To review the pathology of the mitral valve (MV) and long-term outcomes of surgery in patients with Marfan syndrome (MFS). (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 27, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Tirone E. David, Joy Park, Chun-Po Steve Fan Tags: Adult Source Type: research
Transient receptor potential vanilloid 4 channel inhibition attenuates lung ischemia-reperfusion injury in a porcine lung transplant model
Transient receptor potential vanilloid 4 (TRPV4) is a nonselective cation channel important in many physiological and pathophysiological processes, including pulmonary disease. Using a murine model, we previously demonstrated that TRPV4 mediates lung ischemia-reperfusion injury, the major cause of primary graft dysfunction after transplant. The current study tests the hypothesis that treatment with a TRPV4 inhibitor will attenuate lung ischemia-reperfusion injury in a clinically relevant porcine lung transplant model. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 27, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Raymond J. Strobel, Huy Q. Ta, Andrew M. Young, Alex M. Wisniewski, Anthony V. Norman, Evan P. Rotar, Mark H. Stoler, Irving L. Kron, Swapnil K. Sonkusare, Mark E. Roeser, Victor E. Laubach Tags: Thoracic Source Type: research
Reply: Defining successful decannulation from extracorporeal life support (ECLS)
We appreciate the interest in our article and commentary by Mariani and colleagues1 regarding our retrospective, single-center study of outcomes of patients successfully weaned from extracorporeal life support.2 First, we agree wholeheartedly that there is a need for standardized language in the extracorporeal membrane oxygenation (ECMO) space regarding what defines successful decannulation/weaning, myocardial recovery. In addition, we applaud Dr Mariani's and Dr Lorruso's team's efforts to shed light on reporting differences in the literature and define the “venoarterial-ECMO gap,” or the patients who are weaned from ...
Source: The Journal of Thoracic and Cardiovascular Surgery - April 27, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Ashley Zhang, Koji Takeda Tags: Letter to the Editor Source Type: research
The American Association for Thoracic Surgery (AATS) 2024 Expert Consensus Document: Management of neonates and infants with Ebstein anomaly.
Symptomatic neonates and infants with Ebstein Anomaly (EA) require complex management. A group of experts was commissioned by the American Association for Thoracic Surgery to provide a framework on this topic focusing on risk stratification and management. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 27, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Igor E. Konstantinov, Paul Chai, Emile Bacha, Christopher A. Caldarone, Jose Pedro Da Silva, Luciana Da Fonseca Da Silva, Joseph Dearani, Lisa Hornberger, Christopher Knott-Craig, Pedro del Nido, Muhammad Qureshi, George Sarris, Vaughn Starnes, Victor Tsa Source Type: research
Personalizing Patient Risk of a Life Altering Event: An Application of Machine Learning to Hemiarch Surgery
To assess a machine learning model ’s ability to predict the occurrence of life altering events (LAE) in hemiarch surgery and determine contributing patient characteristics and intraoperative factors. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 27, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Adam M. Carroll, Nicolas Chanes, Ananya Shah, Lance Dzubinski, Muhammad Aftab, T. Brett Reece Source Type: research
Statin Therapy and Cardiovascular Protection in Type 2 Diabetes: The Role of Baseline LDL-Cholesterol Levels: A Systematic Review and Meta-analysis of Observational Studies
This study aimed to determine the association of statin use in T2D patients with major adverse cardiovascular events (MACE) and all-cause mortality and whether this association differs by baseline LDL-C levels. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 27, 2024 Category: Nutrition Authors: Negin Soroush, Mitra Nekouei Shahraki, Soroush Mohammadi Jouabadi, Masoud Amiri, Elif Aribas, Bruno H. Stricker, Fariba Ahmadizar Source Type: research
Bystander cardiopulmonary resuscitation differences by sex – the role of arrest recognition
Out-of-hospital cardiac arrest (OHCA) is associated with poor survival [1,2,3]. Bystander response, including cardiopulmonary resuscitation (CPR) and the use of an automated external defibrillator (AED), is associated with greater survival and better neurological outcomes [4,5,6]. However, the provision of bystander CPR varies by physical, social, and attitudinal factors related to the bystander and patient [7,8]. There is also emerging evidence that bystander response may differ depending on the patient ’s sex [9,10,11]. (Source: Resuscitation)
Source: Resuscitation - April 27, 2024 Category: Emergency Medicine Authors: Sonali Munot, Janet E Bray, Julie Redfern, Adrian Bauman, Simone Marschner, Christopher Semsarian, Alan Robert Denniss, Andrew Coggins, Paul M Middleton, Garry Jennings, Blake Angell, Saurabh Kumar, Pramesh Kovoor, Matthew Vukasovic, Jason C Bendall, T Ev Tags: Clinical paper Source Type: research
IL-1 signaling pathway, an important target for inflammation surrounding in myocardial infarction
This article reviews the complex series of responses after myocardial infarction, including the involvement of inflammatory cells and the role of cytokines and chemokines, focusing on the progression of the IL-1 family in myocardial infarction as well as the performance of current targeted therapy drugs in experiments. (Source: Inflammopharmacology)
Source: Inflammopharmacology - April 27, 2024 Category: Drugs & Pharmacology Source Type: research
Comparison of six Z-score formulas based on echocardiography for coronary artery lesions in Kawasaki disease
Kawasaki disease (KD) patients are at risk of developing the serious complication of coronary artery dilation (CAD). To diagnose CAD caused by KD, various Z-Score formulas are used worldwide. This paper aims to evaluate the differences and inclusiveness among the six most commonly used Z-Score formulas in diagnosing CAD in Suzhou, China. Additionally, the study seeks to compare the differences in CAD diagnosis among different high-risk factor groups. By doing so, this research provides a valuable reference for accurately diagnosing CAD in KD patients. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 27, 2024 Category: Cardiology Authors: Xueying Si, Cui Hou, Hui Wang, Wenying Yan, Yunjia Tang, Xinlu Hu, Juncheng Ni, Ling Sun, Haitao Lv, Qiu-Qin Xu Source Type: research
Revascularizing Multivessel Coronary Artery Disease in Acute Coronary Syndromes: Choices and Questions
Acute coronary syndrome (ACS) is a leading cause of hospital admissions and mortality worldwide1. Revascularization of coronary artery disease (CAD) has been shown to improve cardiovascular outcomes including mortality in this patient population2. When a clear, single vessel culprit coronary artery lesion is identified on invasive coronary angiography, then the revascularization decision is straightforward with percutaneous coronary intervention (PCI) as the best option3. However, approximately 50% of patients presenting with ACS are found to have multivessel CAD, and then the decision on which revascularization strategy t...
Source: The American Journal of Cardiology - April 27, 2024 Category: Cardiology Authors: Rafic F. Berbarie Tags: Editorial Source Type: research
Precision Cardio-oncology: Update on Omics-Based Diagnostic Methods
Opinion statementCardio-oncology is an emerging interdisciplinary field dedicated to the early detection and treatment of adverse cardiovascular events associated with anticancer treatment, and current clinical management of anticancer-treatment-related cardiovascular toxicity (CTR-CVT) remains limited by a lack of detailed phenotypic data. However, the promise of diagnosing CTR-CVT using deep phenotyping has emerged with the development of precision medicine, particularly the use of omics-based methodologies to discover sensitive biomarkers of the disease. In the future, combining information produced by a variety of omic...
Source: Current Treatment Options in Oncology - April 27, 2024 Category: Cancer & Oncology Source Type: research
