A “simple” way for enhanced exosomes to alter gene expression: Simple but wrong–complex but right
Exosomes are a subtype of transport vesicles that are released by almost all cell types and are present in most if not all biologic fluids. Exosomes carry biologically active cargo, especially microRNA (miRNA), and can alter the phenotype of recipient cells. After the Nobel Prize in Physiology or Medicine in 2013 was awarded to 3 groups of investigators for their work on defining how cells communicate with exosomes, there was understandable enthusiasm regarding the possibility of manipulating cellular function with synthetically enhanced exosomes. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 17, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Victor A. Ferraris Tags: Letter to the Editor Source Type: research

Single Ventricle Reconstruction 2.0: A Closer Look at our Understanding of Care for Infants Undergoing the Norwood Procedure
(Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 17, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Tara Karamlou, James Meza, Hani Najm, John J. Nigro, Kevin D. Hill Source Type: research

The Goldilocks Principle and Perioperative Red Cell Transfusion: Overuse, Underuse, Getting it Just Right
(Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 17, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Nadia B. Hensley, Charles H. Brown, Steven M. Frank, Colleen G. Koch Source Type: research

Perioperative chemotherapy is not associated with improved survival in stage I pleomorphic lung cancer
This study aimed to evaluate current trends in treatment and survival of pleomorphic carcinoma. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 17, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Brandon S. Hendriksen, Christopher S. Hollenbeak, Michael F. Reed, Matthew D. Taylor Source Type: research

MicroRNA-25 upregulation protects spinal cords, yet is bad for the heart: The dark side of noncoding RNAS
We read with great interest the article published by Zhao and colleagues,1 which reported that neuroprotection of ischemic spinal cords can be enhanced by exosomes overexpressing microRNA (miRNA) 25 (miR-25). Although a growing number of novel therapies have been developed for the spinal cord damage, a trend toward the discovery of noncoding components of the genome including miRNA can significantly contribute to the clinical medicine and this study served as a prime example. Despite their promise however, the fact remains that miRNA-based therapeutics have yet to enter the clinic. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 16, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Michael G. Katz, Anthony S. Fargnoli, Roger J. Hajjar, Dongtak Jeong Tags: Letter to the Editor Source Type: research

Microrna-based spinal cord protection: The possible side effect cannot be neglected
MicroRNAs (miRNAs) are short, single-stranded, noncoding RNAs that modulate the expression of target proteins by annealing to complementary sequences in their target messenger RNAs (mRNAs). Because individual miRNAs often target numerous related mRNAs, the modulation of a single miRNA can have multiple biologic functions through regulation of different target proteins in different tissues or cells in different physiologic or pathophysiologic processes. Although miRNA-targeted modifications are becoming an attractive tool in preclinical study, they still have not entered the clinic. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 16, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Enyi Shi Tags: Letter to the Editor Source Type: research

Higher clinical suspicion is needed for prompt diagnosis of esophageal adenocarcinoma in young patients
Esophageal cancer is considered a disease of the elderly. Although the incidence of esophageal adenocarcinoma in young patients is increasing, guidelines for endoscopic evaluation of gastroesophageal reflux disease and Barrett ’s esophagus include age as a cutoff. There is a paucity of data on the presentation and treatment of esophageal cancer in young patients. Most studies are limited by small sample sizes and conflicting findings are reported regarding delayed diagnosis and survival compared to older patients. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 16, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Tamar Nobel, Michael Curry, Renee Gennarelli, David Jones, Daniela Molena Source Type: research

Return to Intended Oncologic Treatment After Surgery for Malignant Pleural Mesothelioma
Trimodality therapy may prolong survival for patients with resectable malignant pleural mesothelioma (MPM). However, many patients are unable to complete therapy. We sought to identify risk factors for failing to complete adjuvant intensity modulated radiation therapy (IMRT) after cytoreduction for MPM. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 16, 2019 Category: Cardiovascular & Thoracic Surgery Authors: David B. Nelson, David C. Rice, Kyle G. Mitchell, Anne S. Tsao, Daniel R. Gomez, Boris Sepesi, Reza J. Mehran Source Type: research

Left Ventricular Assist Device Implantation May Be Feasible in Appropriately Selected Patients With Severe Renal Insufficiency
Severe renal insufficiency is considered a relative contraindication to left ventricular assist device (LVAD) implantation. After establishing an algorithmic approach to these patients, we hypothesized that LVAD implantation with severe renal insufficiency could be performed without increasing morbidity or mortality. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 15, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Chetan Pasrija, Douglas Tran, Praveen George, Erik Sorensen, David J. Kaczorowski, Van-Khue Ton, Zachary N. Kon, LVAD in Renal Failure Group Source Type: research

Computer tomography guided platinum microcoil lung surgery: A cross sectional study
To provide a 5-year update on our tertiary-level institutional experience with CT-guided platinum microcoil lung surgery. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 14, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Anna L. McGuire, Arthur Vieira, Kyle Grant, John Mayo, Tony Sedlic, James Choi, John Yee Source Type: research

Frozen elephant trunk does not increase incidence of paraplegia in patients with acute type A aortic dissection
We seek to assess the safety of total arch replacement (TAR) with frozen elephant trunk (FET) for acute type A aortic dissection (ATAAD) in respect to the risks of operative mortality, stroke and paraplegia using an international multi-centre registry (ARCH). (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 14, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Shi Sum Poon, David H. Tian, Tristan Yan, Deborah Harrington, Omar Nawaytou, Manoj Kuduvalli, Axel Haverich, Marek Ehrlich, Wei-Guo Ma, Li-Zhong Sun, Anthony L. Estrera, Mark Field, International Aortic Arch Surgery Study Group (IAASSG) Source Type: research

Aortic homografts: Should we really lose the opportunity?
We thank Crestanello1 for the precise analysis of our report. As rightfully stated, the results published on the long-term follow-up of cryopreserved allograft (CA) for aortic valve replacement drop a veil of uncertainty on the durability of allogenic tissue in the second  decade after implantation, considering the increased rate of reoperation for structural valve degeneration and its associated risk. We agree that the use of CA should be tailored to certain categories of patients and indeed in our study the main indication for allograft implantation was infective endocarditis (IE). (Source: The Journal of Thoracic a...
Source: The Journal of Thoracic and Cardiovascular Surgery - April 13, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Francesco Nappi, Cristiano Spadaccio, Massimo Chello Tags: Adult: Aorta Valve: Letter to the Editor Source Type: research

Discussion
Dr Daniela Molena (New York, NY). I want to congratulate you for the excellent presentation and for being an example for all of us on how you can use technology to improve patient care. You and your colleagues have extensive experience in using intraoperative molecular imaging both with receptor and no receptor targeted dyes, and we saw a beautiful presentation in our skill sessions on Saturday as well. You have used tumor fluorescence for localization but also for margin assessment, and now, as we saw in this presentation, for finding metastasis. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 13, 2019 Category: Cardiovascular & Thoracic Surgery Source Type: research

Discussion
Dr Scott Silvestry (Orlando, Fla). Thank you for the opportunity to discuss this paper and thank you as well for the copy of the manuscript ahead of time. In our paper that we published in the Journal of Heart and Lung Transplantation in January, we found nearly the same results in that no survival difference and a suggestion of delay to readmission in a large trial, a large database. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 13, 2019 Category: Cardiovascular & Thoracic Surgery Source Type: research

Editorial Board
(Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 13, 2019 Category: Cardiovascular & Thoracic Surgery Source Type: research

Table of Contents
(Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 13, 2019 Category: Cardiovascular & Thoracic Surgery Source Type: research

Recent Papers in the Seminars and Op Techs
Readers who found these articles interesting may also like to read these papers that can be found in recent issues of our sister publications, Seminars in Thoracic and Cardiovascular Surgery and Operative Techniques in Thoracic and Cardiovascular Surgery. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 13, 2019 Category: Cardiovascular & Thoracic Surgery Source Type: research

Information for Readers
(Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 13, 2019 Category: Cardiovascular & Thoracic Surgery Source Type: research

AATS Foundation
The AATS Foundation is a vital part of the American Association for Thoracic Surgery ’s mission, providing a significant impact on a broad number of individuals by training the leaders of the future. Your support is critical to enhancing the skills and knowledge of the next generation of cardiothoracic surgeons throughout the world and continuing the advancement of global innovat ion in the specialty. Please make a gift to the AATS Foundation today. Donating to an AATS Foundation program helps to fulfill the mission of supporting cardiothoracic surgeons in research and education. (Source: The Journal of Thoracic...
Source: The Journal of Thoracic and Cardiovascular Surgery - April 13, 2019 Category: Cardiovascular & Thoracic Surgery Tags: Announcement Source Type: research

WTSA 45th Annual Meeting
June 26-29, 2019 (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 13, 2019 Category: Cardiovascular & Thoracic Surgery Tags: Announcement Source Type: research

Applications for WTSA Membership
The WTSA is now accepting Applications for Membership online for Active as well as Candidate membership status for  the 2020 membership cycle. Visit the WTSA Web site at www.westernthoracic.org to read the complete membership eligibility requirements and to initiate an online application. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 13, 2019 Category: Cardiovascular & Thoracic Surgery Tags: Announcement Source Type: research

ABTS Announcement
The American Board of Thoracic Surgery's Maintenance of Certification program was adopted 9 years ago. Since that time, there has been a continuous evaluation in the Board's thinking about the overall process, based upon internal discussions and input from our Diplomates. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 13, 2019 Category: Cardiovascular & Thoracic Surgery Tags: Announcement Source Type: research

ABTS Requirements for the 10-Year Milestone for Maintenance of Certification
Diplomates of the American Board of Thoracic Surgery (ABTS) who plan to participate in the 10-Year Milestone for the Maintenance of Certification (MOC) process as Certified-Active must hold a currently valid, full, and unrestricted license to practice medicine. Diplomates must  have privileges at a hospital(s) accredited by the JCAHO or other institutions judged acceptable by the Board. Diplomates must also submit letter(s) of reference documenting their level of clinical activity and stature within the surgical community from the VP of Medical Affairs and one other re sponsible member on staff at their prin...
Source: The Journal of Thoracic and Cardiovascular Surgery - April 13, 2019 Category: Cardiovascular & Thoracic Surgery Tags: Announcement Source Type: research

A new tool to assess frailty
Yanagawa and colleagues1 propose another tool to properly assess frailty before cardiac surgery. The comprehensive assessment of frailty score, based on a group of simple and readily available clinical and laboratory measures, carries the potential not only to predict hospital stay after surgery but also to predict 30-day and 1-year mortality. Further studies should propose the simplest and most effective way to identify frailty and to predict results after surgery. Yanagawa and colleagues1 conclude that evidence-based scales of frailty should be used not only to guide patient selection for surgery but also to determine ho...
Source: The Journal of Thoracic and Cardiovascular Surgery - April 13, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Michel Carrier Tags: Letter to the Editor Source Type: research

Current evidence for prosthesis selection: What can we really say?
(Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 13, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Peter Chiu, Andrew B. Goldstone, Michael P. Fischbein, Y.Joseph Woo Source Type: research

Foregut Function Before and After Lung Transplant
Esophageal dysmotility and gastroesophageal reflux disease (GERD) are common in patients with advanced lung disease, and can potentially affect outcomes of lung transplant (LTx); however, the effects of LTx on foregut function remain unknown. We assessed foregut function before and after bilateral LTx. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 13, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Takahiro Masuda, Sumeet K. Mittal, Bal ázs Kovács, Michael A. Smith, Rajat Walia, Jasmine L. Huang, Ross M. Bremner Source Type: research

A Year at the Forefront of General Thoracic Surgery
(Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 12, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Bryan M. Burt Source Type: research

Discussion
Dr Christian P. Brizard (Parkville, Australia). Thank you very much, Dr Mainwaring, for this nice presentation and for sending me all the data beforehand. Your team at Stanford has put a lot of effort into promoting and educating the community in the technique that you are advocating, and the goal has been attained many times over, and we want to congratulate you for that, too. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 11, 2019 Category: Cardiovascular & Thoracic Surgery Source Type: research

Back to the drawing board
Neonates and infants with complex congenital heart disease are at increased risk for adverse neurodevelopmental outcomes relative to children without heart disease. If risk factors for such adverse outcomes could be identified, alternative treatment approaches tailored to different phenotypes might be developed. Further, insights about the mechanistic explanation for adverse outcomes associated with certain risk factors may suggest strategies to mitigate the potential deleterious impact of the risk factor. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 10, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Erin E. Gordon, Robert D.B. Jaquiss Tags: Letter to the Editor Source Type: research

Comprehensive assessment of frailty score as a tool to assess potential recovery in cardiac surgery
We read with great interest the recent article by Yanagawa and colleagues.1 The authors conclude that routine frailty assessments should be implemented in cardiac surgery, and that we need to develop better tools with long-term outcome measures to assess potential recovery. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 10, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Yaron D. Barac, Efrat Kurtzwald Josefson, Milton Saute, Danny Gorphil, Victor Rubchevsky, Dan Aravot Tags: Letter to the Editor Source Type: research

Accurate reporting of clinical trials
We were surprised to read Dr Lamy's Editorial Commentary,1 in which he describes his first reaction ( “I was reading fake news”) when asked to review our manuscripts reporting the 1-year results of the Aspirin and Tranexamic Acid for Coronary Artery Surgery (ATACAS) trial.2,3 We wish to reassure readers of the Journal that the content of these articles accurately represents the work undertaken a nd the observed results. It is disappointing that Dr Lamy does not encourage readers to read the entire article, in which the answers to his queries can be found. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 10, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Paul S. Myles, Julian A. Smith Tags: Letter to the Editor Source Type: research

Minimizing the gap between expectations and reality of mitral valve repair in infective endocarditis
We thank Nappi and colleagues for their letter in response to our report, which used a nationwide population-based database to demonstrate the superior outcomes achieved through mitral valve (MV) repair compared with MV replacement in patients with infective endocarditis (IE), even after correction of confounders including basic demographics, comorbidities, and level of hospital.1 Shortly before the publication of our study, Toyoda and colleagues2 used the New York State database and reported similar findings in the Journal. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 9, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Shao-Wei Chen, Hsiu-An Lee, Victor Chien-Chia Wu Tags: Letter to the Editor Source Type: research

Comparison of Pulmonary Segmentectomy and Lobectomy: Safety Results of a Randomized Trial
Segmentectomy showed no difference in almost all postoperative measures of intraoperative and postoperative complications compared with lobectomy, except segmentectomy was associated with higher chance of air leak. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 9, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Kenji Suzuki, Hisashi Saji, Keiju Aokage, Shun-ichi Watanabe, Morihito Okada, Junki Mizusawa, Ryu Nakajima, Masahiro Tsuboi, Shinichiro Nakamura, Kenichi Nakamura, Tetsuya Mitsudomi, Hisao Asamura, West Japan Oncology Group (WJOG) and Japan Clinical Oncol Source Type: research

Anomalous systemic arterial to right upper lobe pulmonary artery fistula: A case report
(Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 9, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Yoshitaro Saito, Hideki Kawai Source Type: research

Cerebral perfusion in debranching thoracic endovascular aortic repair monitored by orbital Doppler
(Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 8, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Nobuo Kondo, Nobuyuki Hirose, Kazuki Kihara, Kazumasa Orihashi Source Type: research

Intercostal Artery Stent Grafting to Prevent Paraplegia During Endovascular Treatment of an Intercostal Loop Graft Aneurysm After Thoracoabdominal Aortic Aneurysm Repair
(Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 8, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Bruce L. Tjaden, Anthony L. Estrera, Rana O. Afifi Source Type: research

Discussion
Dr Anthony L. Estrera (Houston, Tex). I have nothing to disclose regarding this presentation. Congratulations, Dr Heo, on a nicely presented article. The authors previously demonstrated the unfavorable remodeling that has occurred when residual dissection involves the arch vessels after type A dissection repair after open conventional repair, basically hemiarch repair. Moving more distally, in this article they wanted to analyze the effect of the tear on dissection on longer-term outcomes with regard to type A dissection repair and performed and excluded all the patients who did not have total arch replacement. (Source: Th...
Source: The Journal of Thoracic and Cardiovascular Surgery - April 8, 2019 Category: Cardiovascular & Thoracic Surgery Source Type: research

Discussion
Dr Ram Kumar Subramanyan (Los Angeles, Calif). Yerebakan and colleagues provide valuable animal model data on the benefit of cPAB after doxorubicin-induced cardiac dysfunction. The concept is of significance to the scientific community, today's presentation was excellent, and the manuscript you sent me is absolutely well written. Congratulations on a job well done. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 8, 2019 Category: Cardiovascular & Thoracic Surgery Source Type: research

Discussion
Craig J. Baker (Los Angeles, Calif). The next presentation is entitled, “Outcomes After Thoracic Endovascular Aortic Repair in Patients With Chronic Kidney Disease in the Medicare Population,” presented by Chase Brown on behalf of his colleagues from the University of Pennsylvania. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 5, 2019 Category: Cardiovascular & Thoracic Surgery Source Type: research

Discussion
Dr J. Gaynor (Philadelphia, Pa). As we have heard this morning, most of the children who undergo an unroofing for anomalous aortic origin of the coronary are asymptomatic, and we are essentially performing a prophylactic operation. So in that case, both the short- and long-term safety have to be of utmost importance, and unfortunately as we have heard and as you suggested here, late competence of the aortic valve cannot always be guaranteed with the standard operation. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 5, 2019 Category: Cardiovascular & Thoracic Surgery Source Type: research

Surfactant protein A and D personalized medicine: A healthy day at the SP-A
We thank Drs Guo and Krupnick, and Dr Lin, for starting the dialog with their commentaries. Lin says that apart from surfactant protein (SP) –A, steroids have multiple effects on cytokine production and so on. We would like to note that SP-A has been shown to affect proinflammatory cytokine production (tumor necrosis factor-α, interleukin [IL]-1β, IL-6, IL-8, etc) in a dose dependent manner by either peripheral blood mononuclear cell s or a macrophagelike cell line, and also that the human SP-A variants have been shown to differentially affect the production of cytokines. (Source: The Journal of Thoracic a...
Source: The Journal of Thoracic and Cardiovascular Surgery - April 5, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Joanna Floros, Frank D'Ovidio Tags: Letter to the Editor Source Type: research

The clinical decision algorithm: If it's too complicated, we won't remember it, if it's too hard, we won't use it
We thank Barac and colleagues1 for their interest in our work and for sharing their experiences with use of the comprehensive assessment of frailty (CAF) tool to predict duration of hospitalization as a measure of recovery after cardiac surgery. We agree that the development of clinical prediction scores that incorporate frailty measures are urgently needed.2 Rapid advances in medical informatics will make available patient data from larger and larger databases to develop such scores for vulnerable subpopulations. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 5, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Bobby Yanagawa, Rakesh C. Arora Tags: Letter to the Editor Source Type: research

Noncoronary sinus segment: Nuances of a decision to resect
We thank Assi and colleagues from the University of Pennsylvania group for their letter regarding our recently-published study on the natural history of the aortic root after replacement of the aortic valve and ascending aorta in patients with bicuspid and tricuspid aortic valves.1 Their questions regarding the inclusion of patients who underwent replacement of the noncoronary sinus (NCS) in our study are valid and have prompted us to do a subgroup analysis of this subpopulation. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 4, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Sonya K. Hui, Christopher M. Feindel, Maral Ouzounian Tags: Letter to the Editor Source Type: research

Discussion
Dr Manuel Antunes (Coimbra, Portugal). I would like to thank the Association for the privilege of discussing this interesting paper. Dr Brown, I enjoyed your short presentation and thank you for sending me the manuscript in advance. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 4, 2019 Category: Cardiovascular & Thoracic Surgery Source Type: research

Discussion
Dr Daniel Kreisel (St Louis, Mo). Congratulations on your nice presentation and thank you for sending me the paper in advance. Your group published this model in The American Journal of Transplantation in 2016, and this current work represents a very nice and elegant model to study the responses of cells isolated from lung transplant recipients in vivo. Your results suggest that the development of transplant arteriosclerosis in humanized mice correlates with the development of chronic lung allograft dysfunction (CLAD) in human lung recipients and that regulatory T cells may inhibit the development of graft pathology. (Sour...
Source: The Journal of Thoracic and Cardiovascular Surgery - April 4, 2019 Category: Cardiovascular & Thoracic Surgery Source Type: research

Apical Myectomy for Patients with Hypertrophic Cardiomyopathy and Advanced Heart Failure
In this study, we describe early outcomes of patients with apical HCM following transapical myectomy and compare survival to that of patients with hypertrophic cardiomyopathy listed for heart transplantation. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 4, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Anita Nguyen, Hartzell V. Schaff, Rick A. Nishimura, Jeffrey B. Geske, Joseph A. Dearani, Katherine S. King, Steve R. Ommen Source Type: research

4D Flow MRI reveals altered blood flow patterns in the ascending aorta of VSARR patients
To compare aortic flow patterns in patients following David valve-sparing aortic root replacement (VSARR) with physiologically shaped sinus prostheses (SP) or conventional tube grafts (TG) to healthy volunteers. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 4, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Thekla H. Oechtering, Malte Sieren, Peter Hunold, Anja Hennemuth, Markus Huellebrand, Michael Scharfschwerdt, Doreen Richardt, Hans-Hinrich Sievers, J örg Barkhausen, Alex Frydrychowicz Source Type: research

Right Ventricular Function and Residual Mitral Regurgitation After LVAD Determines the Incidence of Right Heart Failure
Impact of significant mitral regurgitation (MR) on outcomes following continuous flow left ventricular assist device (cfLVAD) remains unclear. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 4, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Paul C. Tang, Jonathan W. Haft, Matthew A. Romano, Abbas Bitar, Reema Hasan, Maryse Palardy, Xiaoting Wu, Keith D. Aaronson, Francis D. Pagani Source Type: research

Discussion
Dr Thomas L. Spray (Philadelphia, Pa). These authors have collected extensive preoperative, intraoperative, and postoperative data on 216 neonates and infants with truncus over a 7-year period at 15 centers in the United States to evaluate the potential risk factors for major adverse cardiac events after repair. Twenty-one percent of the population had a major event and 16 patients died, or 7% of the total, 10% required ECMO, and 12% cardiopulmonary resuscitation in the postoperative period. The data from these 15 centers is remarkably similar to the collected data from the STS Congenital Heart Surgery Database in terms of...
Source: The Journal of Thoracic and Cardiovascular Surgery - April 3, 2019 Category: Cardiovascular & Thoracic Surgery Source Type: research

Discussion
Dr Sai Yendamuri (Buffalo, NY). Thank you for the opportunity to discuss this paper, excellent work, Brendon, and thanks for sending me the manuscript well ahead of time. I have a few quick questions. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 3, 2019 Category: Cardiovascular & Thoracic Surgery Source Type: research