Using functional principal component analysis (FPCA) to quantify sitting patterns derived from wearable sensors
CONCLUSION: In this work we implemented MFPCA to identify variation in movement patterns during sitting bouts, and showed that these patterns were associated with cardiovascular health. Unlike existing methods, MFPCA does not require pre-specified cut-points to define activity intensity, and thus offers a novel powerful statistical tool to elucidate variation in SB patterns and health.TRIAL REGISTRATION: ClinicalTrials.gov NCT03473145; Registered 22 March 2018; https://clinicaltrials.gov/ct2/show/NCT03473145 ; International Registered Report Identifier (IRRID): DERR1-10.2196/28684.PMID:38671485 | DOI:10.1186/s12966-024-015...
Source: Health Physics - April 26, 2024 Category: Physics Authors: Rong W Zablocki Sheri J Hartman Chongzhi Di Jingjing Zou Jordan A Carlson Paul R Hibbing Dori E Rosenberg Mikael Anne Greenwood-Hickman Lindsay Dillon Andrea Z LaCroix Loki Natarajan Source Type: research
A Review of Phyto- and Microbial-remediation of indoor volatile organic compounds
This study presents the major sources of VOCs in indoor environments and their compositions. Various herbaceous and woody plants used to mitigate indoor VOCs are summarized and their VOCs removal performance is compared. Moreover, this paper reviews the current state of active phytoremediation and microbial remediation for the control of indoor VOCs, and discusses future directions.PMID:38670503 | DOI:10.1016/j.chemosphere.2024.142120 (Source: Chemosphere)
Source: Chemosphere - April 26, 2024 Category: Chemistry Authors: Min-Hao Yuan Sookyung Kang Kyung-Suk Cho Source Type: research
Construct validity and test-retest reliability of a chrononutrition questionnaire for shift work and non-shift work populations
Chronobiol Int. 2024 Apr 26:1-15. doi: 10.1080/07420528.2024.2342937. Online ahead of print.ABSTRACTThe irregular eating patterns of both shift workers and evening chronotypes adversely affect cardiometabolic health. A tool that conveniently captures temporal patterns of eating alongside an indicator of circadian rhythm such as chronotype will enable researchers to explore relationships with diverse health outcome measures. We aimed to investigate the test-retest reliability and convergent validity of a Chrononutrition Questionnaire (CNQ) that captures temporal patterns of eating and chronotype in the general population (n...
Source: Chronobiology International - April 26, 2024 Category: Biology Authors: Yan Yin Phoi Maxine P Bonham Michelle Rogers Jillian Dorrian Alison M Coates Source Type: research
Computational model captures cardiac growth in hypertensive pregnancies and in the postpartum period
In this study, we evaluated whether this model could capture heart growth beyond normal pregnancy. After further validation of our normal pregnancy predictions, we tested our model predictions of three rat studies of hypertensive pregnancies. Next, we simulated the postpartum period and examined the impact of lactation on cardiac growth in rats. We demonstrate that our multiscale model can capture cardiac growth associated with new-onset hypertension during pregnancy and lactation status in the postpartum period. We conclude by elaborating on the potential clinical utility of our model in the future.PMID:38668702 | DOI:10....
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 26, 2024 Category: Physiology Authors: Molly S Kaissar Kyoko Yoshida Source Type: research
Understanding changes in echocardiographic parameters at different ages following fetal growth restriction: a systematic review and meta-analysis
Am J Physiol Heart Circ Physiol. 2024 Apr 26. doi: 10.1152/ajpheart.00052.2024. Online ahead of print.ABSTRACTFetal growth restriction (FGR) increases cardiovascular risk by cardiac remodeling and programming. This systematic review and meta-analysis across species examines the use of echocardiography in FGR offspring at different ages. PubMed and Embase.com were searched for animal and human studies reporting on echocardiographic parameters in placental insufficiency-induced FGR offspring. We included 6 animal and 49 human studies. While unable to perform a meta-analysis of animal studies due to insufficient number of stu...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 26, 2024 Category: Physiology Authors: Mette van de Meent Kirsten T Nijholt Shary C A Joemmanbaks Judith Kooiman Henk S Schipper Kim E Wever A Titia Lely Fieke Terstappen Source Type: research
Modeling heart failure with preserved ejection fraction in female mice: an elusive target
Am J Physiol Heart Circ Physiol. 2024 Apr 26. doi: 10.1152/ajpheart.00139.2024. Online ahead of print.NO ABSTRACTPMID:38668704 | DOI:10.1152/ajpheart.00139.2024 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 26, 2024 Category: Physiology Authors: Taben M Hale Erik A Blackwood Source Type: research
Unravelling the role of cathepsins in cardiovascular diseases
Mol Biol Rep. 2024 Apr 26;51(1):579. doi: 10.1007/s11033-024-09518-1.ABSTRACTLysosomal cathepsins as a regulatory medium have been assessed as potential therapeutic targets for the treatment of various cardiac diseases such as abdominal aortic aneurysm, hypertension, cardiomyopathy, coronary heart disease, atherosclerosis, etc. They are ubiquitous lysosomal proteases with papain-like folded protein structures that are involved in a variety of physiological processes, such as the digestion of proteins, activation of pro-inflammatory molecules, degradation of extracellular matrix components, and maturation of peptide hormone...
Source: Molecular Biology Reports - April 26, 2024 Category: Molecular Biology Authors: Sonali Maheshwari Bhoomika M Patel Source Type: research
Effects of Trehalose Preconditioning on H9C2 Cell Viability and Autophagy Activation in a Model of Donation after Circulatory Death for Heart Transplantation
Curr Issues Mol Biol. 2024 Apr 12;46(4):3353-3363. doi: 10.3390/cimb46040210.ABSTRACTDonation after circulatory death (DCD) is a promising strategy for alleviating donor shortage in heart transplantation. Trehalose, an autophagy inducer, has been shown to be cardioprotective in an ischemia-reperfusion (IR) model; however, its role in IR injury in DCD remains unknown. In the present study, we evaluated the effects of trehalose on cardiomyocyte viability and autophagy activation in a DCD model. In the DCD model, cardiomyocytes (H9C2) were exposed to 1 h warm ischemia, 1 h cold ischemia, and 1 h reperfusion. Trehalose was adm...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Jingwen Gao Yasushige Shingu Satoru Wakasa Source Type: research
A preoperative use of manual therapy in a patient with idiopathic pulmonary fibrosis awaiting lung transplant: a case report
DISCUSSION: The utilization of MT appeared to address the patient's impairments, improved quality of life, improved pulmonary function and improved transplant outcomes.PMID:38666526 | DOI:10.1080/09593985.2024.2343046 (Source: Physiotherapy Theory and Practice)
Source: Physiotherapy Theory and Practice - April 26, 2024 Category: Physiotherapy Authors: Beth Moody Jones Adam Walsh Kathy Lee Bishop Source Type: research
The inhibitory effects of endophytic metabolites on glycated proteins under non-communicable disease conditions: A review
Int J Biol Macromol. 2024 Apr 24:131869. doi: 10.1016/j.ijbiomac.2024.131869. Online ahead of print.ABSTRACTProtein glycation in human body is closely linked to the onset/progression of diabetes associated complications. These glycated proteins are commonly known as advanced glycation end products (AGEs). Recent literature has also highlighted the involvement of AGEs in other non-communicable diseases (NCDs) such as cardiovascular, cancer, and Alzheimer's diseases and explored the impact of plant metabolites on AGEs formation. However, the significance of endophytic metabolites against AGEs has recently garnered attention ...
Source: International Journal of Biological Macromolecules - April 26, 2024 Category: Biochemistry Authors: Muhammad Nawaz Muhammad Naveed Afridi Irfan Ullah Iftikhar Ali Khan Muhammad Saqib Ishaq Yuting Su Hafiz Muhammad Rizwan Ka-Wing Cheng Qian Zhou Mingfu Wang Source Type: research
Gelatin/heparin coated bio-inspired polyurethane composite fibers to construct small-caliber artificial blood vessel grafts
Int J Biol Macromol. 2024 Apr 24:131849. doi: 10.1016/j.ijbiomac.2024.131849. Online ahead of print.ABSTRACTLong-term patency and ability for revascularization remain challenges for small-caliber blood vessel grafts to treat cardiovascular diseases clinically. Here, a gelatin/heparin coated bio-inspired polyurethane composite fibers-based artificial blood vessel with continuous release of NO and biopeptides to regulate vascular tissue repair and maintain long-term patency is fabricated. A biodegradable polyurethane elastomer that can catalyze S-nitrosothiols in the blood to release NO is synthesized (NPU). Then, the NPU co...
Source: International Journal of Biological Macromolecules - April 26, 2024 Category: Biochemistry Authors: Zehong Xiang Honghong Chen Baofeng Xu Haozheng Wang Tianci Zhang Xinghua Guan Zhifang Ma Kuntang Liang Qiang Shi Source Type: research
A Review of Phyto- and Microbial-remediation of indoor volatile organic compounds
This study presents the major sources of VOCs in indoor environments and their compositions. Various herbaceous and woody plants used to mitigate indoor VOCs are summarized and their VOCs removal performance is compared. Moreover, this paper reviews the current state of active phytoremediation and microbial remediation for the control of indoor VOCs, and discusses future directions.PMID:38670503 | DOI:10.1016/j.chemosphere.2024.142120 (Source: Chemosphere)
Source: Chemosphere - April 26, 2024 Category: Chemistry Authors: Min-Hao Yuan Sookyung Kang Kyung-Suk Cho Source Type: research
Roles of AhR/CYP1s Signal Pathway Mediated ROS Production in Uremic Cardiomyopathy
CONCLUSION: This study provides evidence that the AhR/CYP1s pathway is activated in UCM rats, and this activation is correlated with the uremic toxin IS. In vitro studies indicate that IS can stimulate the AhR translocation in cardiomyocyte, triggering to the production of intracellular ROS via CYP1s. This process leads to prolonged oxidative stress stimulation and thus contributes to the progression of uremic toxin-mediated cardiomyopathy.PMID:38670245 | DOI:10.1016/j.toxlet.2024.04.005 (Source: Toxicology Letters)
Source: Toxicology Letters - April 26, 2024 Category: Toxicology Authors: Wei Lu Shi Cheng Jiarui Xu Zilong Xiao Yong Yu Qiwen Xie Yi Fang Ruizhen Chen Bo Shen Yeqing Xie Xiaoqiang Ding Source Type: research
Cardiovascular Arrest Due to Postrenal Kidney Injury
Dtsch Arztebl Int. 2024 Mar 22;121(6):181. doi: 10.3238/arztebl.m2023.0105.NO ABSTRACTPMID:38666671 | DOI:10.3238/arztebl.m2023.0105 (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - April 26, 2024 Category: General Medicine Authors: Juri Mattern Marc-Sebastian Baier J ürgen Majolk Source Type: research
Association of the trimethylamine N-oxide with cardiovascular risk and vascular alterations in middle-aged patients with risk factors for cardiovascular diseases
Conclusions: TMAO levels are increased with expanded CVD risk. Across different types of vascular damage, TMAO is associated with atherosclerotic changes.PMID:38669041 | DOI:10.1042/BSR20232090 (Source: Bioscience Reports)
Source: Bioscience Reports - April 26, 2024 Category: Biomedical Science Authors: Natalia Spasova Desislava Somleva Bozhidar Krastev Radostina Ilieva Angelina Borizanova Dobrin Svinarov Elena Kinova Assen Goudev Source Type: research
