The Reduced Uterine Perfusion Pressure as a model for preeclampsia and fetal growth restriction in murine: a systematic review and meta-analysis
DISCUSSION: The RUPP is a robust model considering the evident differences in maternal and fetal outcomes. The high heterogeneity reflects the observed variability in phenotype. Due to underreporting, we observed reporting bias and a high risk of bias. We recommend standardizing study design by optimal time point and method chosen for readout measures to limit the variability. This contributes to improved reproducibility and thereby eventually improves the translational value of the RUPP model.PMID:38758122 | DOI:10.1152/ajpheart.00056.2024 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 17, 2024 Category: Physiology Authors: Caren M van Kammen Seija E L Taal Kimberley E Wever Joey P Granger A Titia Lely Fieke Terstappen Source Type: research

The Relation Between Frailty and Hypertension is Partially Mediated by Physical Activity Among Males and Females in the Canadian Longitudinal Study on Aging
Am J Physiol Heart Circ Physiol. 2024 May 17. doi: 10.1152/ajpheart.00179.2024. Online ahead of print.ABSTRACTFrailty reflects the heterogeneity in aging and may lead to the development of hypertension and heart disease, but the frailty-cardiovascular relation and whether physical activity modifies this relation in males and females is unclear. We tested if higher frailty was positively associated with hypertension and heart disease in males and females, and if habitual movement mediated this relation. The relation between baseline frailty with follow-up hypertension and heart disease was investigated using the Canadian Lo...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 17, 2024 Category: Physiology Authors: Myles W O'Brien Olga Theou Source Type: research

Cell-to-cell heterogeneity in ion channel conductance impacts substrate vulnerability to arrhythmia
This study sought to explore the impact of cell-to-cell heterogeneity in ion channel conductance on substrate vulnerability to arrhythmia by measuring the duration of the vulnerable window in computational models of 1-dimensional cables of ventricular cardiomyocytes. We began by using a population of uniform cable models to determine the mechanisms underlying the vulnerable window phenomenon. We found that in addition to the known importance of GNa, the conductances GCaL and GKr also play a minor role in determining the vulnerable window duration. We also found that a steeper slope of the repolarizing action potential duri...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 17, 2024 Category: Physiology Authors: Taylor K Pullinger Eric A Sobie Source Type: research

Through the Haze: Unveiling the Link Between Smoking and Atrial Fibrillation
Am J Physiol Heart Circ Physiol. 2024 May 17. doi: 10.1152/ajpheart.00286.2024. Online ahead of print.NO ABSTRACTPMID:38758125 | DOI:10.1152/ajpheart.00286.2024 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 17, 2024 Category: Physiology Authors: Fleur E Mason Niels Voigt Source Type: research

Fetal cardiac troponin I levels decline towards birth in sheep
CONCLUSIONS We newly report that fetal hs-cTnI levels decline concomitant with reduced proliferation of cardiomyocytes towards term.PMID:38758126 | DOI:10.1152/ajpheart.00224.2024 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 17, 2024 Category: Physiology Authors: Sonnet S Jonker Samantha Louey Source Type: research

Guidelines for Assessing Maternal Cardiovascular Physiology During Pregnancy and Postpartum
Am J Physiol Heart Circ Physiol. 2024 May 17. doi: 10.1152/ajpheart.00055.2024. Online ahead of print.ABSTRACTMaternal mortality rates are at an all-time high across the world and are set to increase in subsequent years. Cardiovascular disease is the leading cause of death during pregnancy and postpartum, especially in the US. Therefore, understanding the physiological changes in the cardiovascular system during normal pregnancy is necessary to understand disease-related pathology. Significant systemic and cardiovascular physiological changes occur during pregnancy that are essential for supporting the maternal-fetal dyad....
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 17, 2024 Category: Physiology Authors: Helen E Collins Barbara T Alexander Alison S Care Margie H Davenport Sandra T Davidge Mansoureh Eghbali Dino A Giussani Martijn F Hoes Colleen G Julian Holly A LaVoie I Mark Olfert Susan E Ozanne Egle Bytautiene Prewit Junie P Warrington Lubo Zhang Stylia Source Type: research

Identification of congenital aortic valve malformations in juvenile natriuretic peptide receptor 2 deficient ( < em > Npr2+/-) < /em > mice using high frequency ultrasound
Am J Physiol Heart Circ Physiol. 2024 May 17. doi: 10.1152/ajpheart.00769.2023. Online ahead of print.ABSTRACTMouse models of congenital aortic valve malformations are useful for studying disease pathobiology, but most models have incomplete penetrance (e.g., ~2 to 77% prevalence of bicuspid aortic valves (BAVs) across multiple models). For longitudinal studies of pathologies associated with BAVs and other congenital valve malformations, which manifest over months in mice, it is operationally inefficient, economically burdensome, and ethically challenging to enroll large numbers of mice in studies without first identifying...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 17, 2024 Category: Physiology Authors: Vrushali Guruji Yu-Qing Zhou Mingyi Tang Zahra Mirzaei Yu Ding Malak Elbatarny Neda Latifi Craig A Simmons Source Type: research

Chronotype and metabolic syndrome in midlife - findings from the Northern Finland Birth Cohort 1966
Am J Physiol Heart Circ Physiol. 2024 May 17. doi: 10.1152/ajpheart.00051.2024. Online ahead of print.ABSTRACTEvening chronotype is known to be associated with various chronic diseases and cardiovascular risk factors. Metabolic syndrome is a group of conditions that together raise the risk of coronary heart disease, diabetes, stroke, and other serious health problems. Only a few studies have been published on the association between chronotype and metabolic syndrome in unselected population data, with conflicting results. The aim of this study was to evaluate the association between chronotype and metabolic syndrome at pop...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 17, 2024 Category: Physiology Authors: Taru Lappalainen Heidi Jurvelin Mikko P Tulppo Paula Pesonen Juha Auvinen Markku Timonen Source Type: research

Both endothelial mineralocorticoid receptor expression and hyperleptinemia are required for clinical characteristics of placental ischemia in mice
CONCLUSIONS: Our data indicate that high leptin levels drive endothelial dysfunction inPE and that ECMR is required for clinical characteristics of hypertension and fetal growth restriction in placental ischemia PE. Collectively, we show that both ECMR and leptin play a role to mediate PE.PMID:38758130 | DOI:10.1152/ajpheart.00188.2024 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 17, 2024 Category: Physiology Authors: Desmond Moronge Victor Ayulo Mona Elgazzaz Elisabeth Mellott Safia Ogbi Jessica L Faulkner Source Type: research

The Reduced Uterine Perfusion Pressure as a model for preeclampsia and fetal growth restriction in murine: a systematic review and meta-analysis
DISCUSSION: The RUPP is a robust model considering the evident differences in maternal and fetal outcomes. The high heterogeneity reflects the observed variability in phenotype. Due to underreporting, we observed reporting bias and a high risk of bias. We recommend standardizing study design by optimal time point and method chosen for readout measures to limit the variability. This contributes to improved reproducibility and thereby eventually improves the translational value of the RUPP model.PMID:38758122 | DOI:10.1152/ajpheart.00056.2024 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 17, 2024 Category: Physiology Authors: Caren M van Kammen Seija E L Taal Kimberley E Wever Joey P Granger A Titia Lely Fieke Terstappen Source Type: research

The Relation Between Frailty and Hypertension is Partially Mediated by Physical Activity Among Males and Females in the Canadian Longitudinal Study on Aging
Am J Physiol Heart Circ Physiol. 2024 May 17. doi: 10.1152/ajpheart.00179.2024. Online ahead of print.ABSTRACTFrailty reflects the heterogeneity in aging and may lead to the development of hypertension and heart disease, but the frailty-cardiovascular relation and whether physical activity modifies this relation in males and females is unclear. We tested if higher frailty was positively associated with hypertension and heart disease in males and females, and if habitual movement mediated this relation. The relation between baseline frailty with follow-up hypertension and heart disease was investigated using the Canadian Lo...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 17, 2024 Category: Physiology Authors: Myles W O'Brien Olga Theou Source Type: research

Cell-to-cell heterogeneity in ion channel conductance impacts substrate vulnerability to arrhythmia
This study sought to explore the impact of cell-to-cell heterogeneity in ion channel conductance on substrate vulnerability to arrhythmia by measuring the duration of the vulnerable window in computational models of 1-dimensional cables of ventricular cardiomyocytes. We began by using a population of uniform cable models to determine the mechanisms underlying the vulnerable window phenomenon. We found that in addition to the known importance of GNa, the conductances GCaL and GKr also play a minor role in determining the vulnerable window duration. We also found that a steeper slope of the repolarizing action potential duri...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 17, 2024 Category: Physiology Authors: Taylor K Pullinger Eric A Sobie Source Type: research

Through the Haze: Unveiling the Link Between Smoking and Atrial Fibrillation
Am J Physiol Heart Circ Physiol. 2024 May 17. doi: 10.1152/ajpheart.00286.2024. Online ahead of print.NO ABSTRACTPMID:38758125 | DOI:10.1152/ajpheart.00286.2024 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 17, 2024 Category: Physiology Authors: Fleur E Mason Niels Voigt Source Type: research

Fetal cardiac troponin I levels decline towards birth in sheep
CONCLUSIONS We newly report that fetal hs-cTnI levels decline concomitant with reduced proliferation of cardiomyocytes towards term.PMID:38758126 | DOI:10.1152/ajpheart.00224.2024 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 17, 2024 Category: Physiology Authors: Sonnet S Jonker Samantha Louey Source Type: research

Guidelines for Assessing Maternal Cardiovascular Physiology During Pregnancy and Postpartum
Am J Physiol Heart Circ Physiol. 2024 May 17. doi: 10.1152/ajpheart.00055.2024. Online ahead of print.ABSTRACTMaternal mortality rates are at an all-time high across the world and are set to increase in subsequent years. Cardiovascular disease is the leading cause of death during pregnancy and postpartum, especially in the US. Therefore, understanding the physiological changes in the cardiovascular system during normal pregnancy is necessary to understand disease-related pathology. Significant systemic and cardiovascular physiological changes occur during pregnancy that are essential for supporting the maternal-fetal dyad....
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 17, 2024 Category: Physiology Authors: Helen E Collins Barbara T Alexander Alison S Care Margie H Davenport Sandra T Davidge Mansoureh Eghbali Dino A Giussani Martijn F Hoes Colleen G Julian Holly A LaVoie I Mark Olfert Susan E Ozanne Egle Bytautiene Prewit Junie P Warrington Lubo Zhang Stylia Source Type: research