Sex differences in the impact of parental obesity on offspring cardiac SIRT3 expression, mitochondrial efficiency and diastolic function early in life
Am J Physiol Heart Circ Physiol. 2021 Jul 23. doi: 10.1152/ajpheart.00176.2021. Online ahead of print.ABSTRACTPrevious studies suggest that parental obesity may adversely impact long-term metabolic health of the offspring. We tested the hypothesis that parental (paternal + maternal) obesity impairs cardiac function in the offspring early in life. Within 1-3 days after weaning, offspring from obese rats fed a high fat diet (HFD-Offs) and age-matched offspring from lean rats (ND-Offs) were submitted to echocardiography and cardiac catheterization for assessment of pressure-volume relationships. Then, hearts were digested and...
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 23, 2021 Category: Physiology Authors: Jussara M do Carmo Ana C M Omoto Xuemei Dai Sydney P Moak Gabriela S Mega Xuan Li Zhen Wang Alan J Mouton John E Hall Alexandre A da Silva Source Type: research

Notch2 Suppression Mimicking Changes in Human Pulmonary Hypertension Modulates Notch1 and Promotes Endothelial Cell Proliferation
Am J Physiol Heart Circ Physiol. 2021 Jul 23. doi: 10.1152/ajpheart.00125.2021. Online ahead of print.ABSTRACTPulmonary arterial hypertension (PAH) is a fatal cardiopulmonary disease characterized by increased vascular cell proliferation with resistance to apoptosis and occlusive remodeling of the small pulmonary arteries in humans. The Notch family of proteins are proximal signaling mediators of an evolutionarily conserved pathway that effect cell proliferation, fate determination, and development. In endothelial cells (ECs), Notch receptor 2 (Notch2) has been shown to promote endothelial apoptosis. However, a pro- or ant...
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 23, 2021 Category: Physiology Authors: Sanghamitra Sahoo Yao Li Daniel de Jesus John Charles Sembrat Ii Mauricio M Rojas Elena Goncharova Eugenia Cifuentes-Pagano Adam C Straub Patrick J Pagano Source Type: research

Blunted peripheral but not cerebral vasodilator function in young otherwise healthy adults with persistent symptoms following COVID-19
Am J Physiol Heart Circ Physiol. 2021 Jul 23. doi: 10.1152/ajpheart.00368.2021. Online ahead of print.ABSTRACTRecent findings suggest that COVID-19 causes vascular dysfunction during the acute phase of the illness in otherwise healthy young adults. To date, no studies have investigated the longer-term effects of COVID-19 on vascular function. Herein, we hypothesized that young, otherwise healthy adults who are past the acute phase of COVID-19 would exhibit blunted peripheral (brachial artery flow-mediated dilation (FMD) and reactive hyperemia) and cerebral vasodilator function (cerebral vasomotor reactivity to hypercapnia;...
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 23, 2021 Category: Physiology Authors: Damsara Nandadeva Benjamin E Young Brandi Y Stephens Ann-Katrin Grotle Rachel J Skow Angela J Middleton Florence P Haseltine Paul J Fadel Source Type: research

Vascular Calcification: a left-handed compliment for aging
Am J Physiol Heart Circ Physiol. 2021 Jul 23. doi: 10.1152/ajpheart.00300.2021. Online ahead of print.NO ABSTRACTPMID:34296967 | DOI:10.1152/ajpheart.00300.2021 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 23, 2021 Category: Physiology Authors: Luke P Brewster Source Type: research

CaMKII inhibition has dual effects on spontaneous Ca < sup > 2+ < /sup > release and Ca < sup > 2+ < /sup > alternans in ventricular cardiomyocytes from mice with a gain-of-function RyR2 mutation
CONCLUSIONS: Inhibition of CaMKII efficiently reduces spontaneous Ca2+-release, but promotes Ca2+ alternans in RyR2-R2474S cardiomyocytes with a gain-of-function RyR2 mutation. The dominant effect in RyR2-R2474S is to reduce spontaneous Ca2+-release, which supports this intervention as a therapeutic strategy in this specific condition. However, future studies on CaMKII inhibition in conditions with increased propensity for Ca2+ alternans should include investigation of both phenomena.PMID:34270372 | DOI:10.1152/ajpheart.00011.2021 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 16, 2021 Category: Physiology Authors: Mani Sadredini Marie Haugsten Hansen Michael Frisk William E Louch Stephan E Lehnart Ivar Sjaastad Mathis Korseberg Stokke Source Type: research

Angiotensin II -induced overexpression of Sirtuin-1 contributes to enhanced expression of Gi α proteins and hyperproliferation of vascular smooth muscle cells
Am J Physiol Heart Circ Physiol. 2021 Jul 16. doi: 10.1152/ajpheart.00898.2020. Online ahead of print.ABSTRACTAngiotensin II (Ang II) plays an important role in the regulation of various physiological functions including proliferation, hypertrophy of vascular smooth muscle cells (VSMC) through the overexpression of Giα proteins. Sirtuin1 (Sirt1), a class III histone deacetylase and epigenetic regulator is implicated in a wide range of cellular functions, including migration and growth of VSMC as well as in Ang II-induced hypertension. The present study was undertaken to examine the role of Sirt1 in Ang II-induced ove...
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 16, 2021 Category: Physiology Authors: Ekhtear Hossain Yuan Li Madhu B Anand-Srivastava Source Type: research

Voltage-Gated Potassium Channel Dysfunction in Dorsal Root Ganglia Contributes to the Exaggerated Exercise Pressor Reflex in Rats with Chronic Heart Failure
Am J Physiol Heart Circ Physiol. 2021 Jul 16. doi: 10.1152/ajpheart.00256.2021. Online ahead of print.ABSTRACTAn exaggerated exercise pressor reflex (EPR) causes excessive sympatho-excitation and exercise intolerance during physical activity in the chronic heart failure (CHF) state. Muscle afferent sensitization contributes to the genesis of the exaggerated EPR in CHF. However, the cellular mechanisms underlying muscle afferent sensitization in CHF remain unclear. Considering that voltage-gated potassium (Kv) channels critically regulate afferent neuronal excitability, we examined the potential role of Kv channels in media...
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 16, 2021 Category: Physiology Authors: Juan Hong Shubin Fu Lie Gao Yanhui Cai Eric D Lazartigues Han-Jun Wang Source Type: research

CaMKII inhibition has dual effects on spontaneous Ca < sup > 2+ < /sup > release and Ca < sup > 2+ < /sup > alternans in ventricular cardiomyocytes from mice with a gain-of-function RyR2 mutation
CONCLUSIONS: Inhibition of CaMKII efficiently reduces spontaneous Ca2+-release, but promotes Ca2+ alternans in RyR2-R2474S cardiomyocytes with a gain-of-function RyR2 mutation. The dominant effect in RyR2-R2474S is to reduce spontaneous Ca2+-release, which supports this intervention as a therapeutic strategy in this specific condition. However, future studies on CaMKII inhibition in conditions with increased propensity for Ca2+ alternans should include investigation of both phenomena.PMID:34270372 | DOI:10.1152/ajpheart.00011.2021 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 16, 2021 Category: Physiology Authors: Mani Sadredini Marie Haugsten Hansen Michael Frisk William E Louch Stephan E Lehnart Ivar Sjaastad Mathis Korseberg Stokke Source Type: research

Angiotensin II -induced overexpression of Sirtuin-1 contributes to enhanced expression of Gi α proteins and hyperproliferation of vascular smooth muscle cells
Am J Physiol Heart Circ Physiol. 2021 Jul 16. doi: 10.1152/ajpheart.00898.2020. Online ahead of print.ABSTRACTAngiotensin II (Ang II) plays an important role in the regulation of various physiological functions including proliferation, hypertrophy of vascular smooth muscle cells (VSMC) through the overexpression of Giα proteins. Sirtuin1 (Sirt1), a class III histone deacetylase and epigenetic regulator is implicated in a wide range of cellular functions, including migration and growth of VSMC as well as in Ang II-induced hypertension. The present study was undertaken to examine the role of Sirt1 in Ang II-induced ove...
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 16, 2021 Category: Physiology Authors: Ekhtear Hossain Yuan Li Madhu B Anand-Srivastava Source Type: research

Voltage-Gated Potassium Channel Dysfunction in Dorsal Root Ganglia Contributes to the Exaggerated Exercise Pressor Reflex in Rats with Chronic Heart Failure
Am J Physiol Heart Circ Physiol. 2021 Jul 16. doi: 10.1152/ajpheart.00256.2021. Online ahead of print.ABSTRACTAn exaggerated exercise pressor reflex (EPR) causes excessive sympatho-excitation and exercise intolerance during physical activity in the chronic heart failure (CHF) state. Muscle afferent sensitization contributes to the genesis of the exaggerated EPR in CHF. However, the cellular mechanisms underlying muscle afferent sensitization in CHF remain unclear. Considering that voltage-gated potassium (Kv) channels critically regulate afferent neuronal excitability, we examined the potential role of Kv channels in media...
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 16, 2021 Category: Physiology Authors: Juan Hong Shubin Fu Lie Gao Yanhui Cai Eric D Lazartigues Han-Jun Wang Source Type: research

CaMKII inhibition has dual effects on spontaneous Ca < sup > 2+ < /sup > release and Ca < sup > 2+ < /sup > alternans in ventricular cardiomyocytes from mice with a gain-of-function RyR2 mutation
CONCLUSIONS: Inhibition of CaMKII efficiently reduces spontaneous Ca2+-release, but promotes Ca2+ alternans in RyR2-R2474S cardiomyocytes with a gain-of-function RyR2 mutation. The dominant effect in RyR2-R2474S is to reduce spontaneous Ca2+-release, which supports this intervention as a therapeutic strategy in this specific condition. However, future studies on CaMKII inhibition in conditions with increased propensity for Ca2+ alternans should include investigation of both phenomena.PMID:34270372 | DOI:10.1152/ajpheart.00011.2021 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 16, 2021 Category: Physiology Authors: Mani Sadredini Marie Haugsten Hansen Michael Frisk William E Louch Stephan E Lehnart Ivar Sjaastad Mathis Korseberg Stokke Source Type: research

Angiotensin II -induced overexpression of Sirtuin-1 contributes to enhanced expression of Gi α proteins and hyperproliferation of vascular smooth muscle cells
Am J Physiol Heart Circ Physiol. 2021 Jul 16. doi: 10.1152/ajpheart.00898.2020. Online ahead of print.ABSTRACTAngiotensin II (Ang II) plays an important role in the regulation of various physiological functions including proliferation, hypertrophy of vascular smooth muscle cells (VSMC) through the overexpression of Giα proteins. Sirtuin1 (Sirt1), a class III histone deacetylase and epigenetic regulator is implicated in a wide range of cellular functions, including migration and growth of VSMC as well as in Ang II-induced hypertension. The present study was undertaken to examine the role of Sirt1 in Ang II-induced ove...
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 16, 2021 Category: Physiology Authors: Ekhtear Hossain Yuan Li Madhu B Anand-Srivastava Source Type: research

Voltage-Gated Potassium Channel Dysfunction in Dorsal Root Ganglia Contributes to the Exaggerated Exercise Pressor Reflex in Rats with Chronic Heart Failure
Am J Physiol Heart Circ Physiol. 2021 Jul 16. doi: 10.1152/ajpheart.00256.2021. Online ahead of print.ABSTRACTAn exaggerated exercise pressor reflex (EPR) causes excessive sympatho-excitation and exercise intolerance during physical activity in the chronic heart failure (CHF) state. Muscle afferent sensitization contributes to the genesis of the exaggerated EPR in CHF. However, the cellular mechanisms underlying muscle afferent sensitization in CHF remain unclear. Considering that voltage-gated potassium (Kv) channels critically regulate afferent neuronal excitability, we examined the potential role of Kv channels in media...
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 16, 2021 Category: Physiology Authors: Juan Hong Shubin Fu Lie Gao Yanhui Cai Eric D Lazartigues Han-Jun Wang Source Type: research

CaMKII inhibition has dual effects on spontaneous Ca < sup > 2+ < /sup > release and Ca < sup > 2+ < /sup > alternans in ventricular cardiomyocytes from mice with a gain-of-function RyR2 mutation
CONCLUSIONS: Inhibition of CaMKII efficiently reduces spontaneous Ca2+-release, but promotes Ca2+ alternans in RyR2-R2474S cardiomyocytes with a gain-of-function RyR2 mutation. The dominant effect in RyR2-R2474S is to reduce spontaneous Ca2+-release, which supports this intervention as a therapeutic strategy in this specific condition. However, future studies on CaMKII inhibition in conditions with increased propensity for Ca2+ alternans should include investigation of both phenomena.PMID:34270372 | DOI:10.1152/ajpheart.00011.2021 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 16, 2021 Category: Physiology Authors: Mani Sadredini Marie Haugsten Hansen Michael Frisk William E Louch Stephan E Lehnart Ivar Sjaastad Mathis Korseberg Stokke Source Type: research

Angiotensin II -induced overexpression of Sirtuin-1 contributes to enhanced expression of Gi α proteins and hyperproliferation of vascular smooth muscle cells
Am J Physiol Heart Circ Physiol. 2021 Jul 16. doi: 10.1152/ajpheart.00898.2020. Online ahead of print.ABSTRACTAngiotensin II (Ang II) plays an important role in the regulation of various physiological functions including proliferation, hypertrophy of vascular smooth muscle cells (VSMC) through the overexpression of Giα proteins. Sirtuin1 (Sirt1), a class III histone deacetylase and epigenetic regulator is implicated in a wide range of cellular functions, including migration and growth of VSMC as well as in Ang II-induced hypertension. The present study was undertaken to examine the role of Sirt1 in Ang II-induced ove...
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 16, 2021 Category: Physiology Authors: Ekhtear Hossain Yuan Li Madhu B Anand-Srivastava Source Type: research

Voltage-Gated Potassium Channel Dysfunction in Dorsal Root Ganglia Contributes to the Exaggerated Exercise Pressor Reflex in Rats with Chronic Heart Failure
Am J Physiol Heart Circ Physiol. 2021 Jul 16. doi: 10.1152/ajpheart.00256.2021. Online ahead of print.ABSTRACTAn exaggerated exercise pressor reflex (EPR) causes excessive sympatho-excitation and exercise intolerance during physical activity in the chronic heart failure (CHF) state. Muscle afferent sensitization contributes to the genesis of the exaggerated EPR in CHF. However, the cellular mechanisms underlying muscle afferent sensitization in CHF remain unclear. Considering that voltage-gated potassium (Kv) channels critically regulate afferent neuronal excitability, we examined the potential role of Kv channels in media...
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 16, 2021 Category: Physiology Authors: Juan Hong Shubin Fu Lie Gao Yanhui Cai Eric D Lazartigues Han-Jun Wang Source Type: research

CaMKII inhibition has dual effects on spontaneous Ca < sup > 2+ < /sup > release and Ca < sup > 2+ < /sup > alternans in ventricular cardiomyocytes from mice with a gain-of-function RyR2 mutation
CONCLUSIONS: Inhibition of CaMKII efficiently reduces spontaneous Ca2+-release, but promotes Ca2+ alternans in RyR2-R2474S cardiomyocytes with a gain-of-function RyR2 mutation. The dominant effect in RyR2-R2474S is to reduce spontaneous Ca2+-release, which supports this intervention as a therapeutic strategy in this specific condition. However, future studies on CaMKII inhibition in conditions with increased propensity for Ca2+ alternans should include investigation of both phenomena.PMID:34270372 | DOI:10.1152/ajpheart.00011.2021 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 16, 2021 Category: Physiology Authors: Mani Sadredini Marie Haugsten Hansen Michael Frisk William E Louch Stephan E Lehnart Ivar Sjaastad Mathis Korseberg Stokke Source Type: research

Angiotensin II -induced overexpression of Sirtuin-1 contributes to enhanced expression of Gi α proteins and hyperproliferation of vascular smooth muscle cells
Am J Physiol Heart Circ Physiol. 2021 Jul 16. doi: 10.1152/ajpheart.00898.2020. Online ahead of print.ABSTRACTAngiotensin II (Ang II) plays an important role in the regulation of various physiological functions including proliferation, hypertrophy of vascular smooth muscle cells (VSMC) through the overexpression of Giα proteins. Sirtuin1 (Sirt1), a class III histone deacetylase and epigenetic regulator is implicated in a wide range of cellular functions, including migration and growth of VSMC as well as in Ang II-induced hypertension. The present study was undertaken to examine the role of Sirt1 in Ang II-induced ove...
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 16, 2021 Category: Physiology Authors: Ekhtear Hossain Yuan Li Madhu B Anand-Srivastava Source Type: research

Voltage-Gated Potassium Channel Dysfunction in Dorsal Root Ganglia Contributes to the Exaggerated Exercise Pressor Reflex in Rats with Chronic Heart Failure
Am J Physiol Heart Circ Physiol. 2021 Jul 16. doi: 10.1152/ajpheart.00256.2021. Online ahead of print.ABSTRACTAn exaggerated exercise pressor reflex (EPR) causes excessive sympatho-excitation and exercise intolerance during physical activity in the chronic heart failure (CHF) state. Muscle afferent sensitization contributes to the genesis of the exaggerated EPR in CHF. However, the cellular mechanisms underlying muscle afferent sensitization in CHF remain unclear. Considering that voltage-gated potassium (Kv) channels critically regulate afferent neuronal excitability, we examined the potential role of Kv channels in media...
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 16, 2021 Category: Physiology Authors: Juan Hong Shubin Fu Lie Gao Yanhui Cai Eric D Lazartigues Han-Jun Wang Source Type: research

CaMKII inhibition has dual effects on spontaneous Ca < sup > 2+ < /sup > release and Ca < sup > 2+ < /sup > alternans in ventricular cardiomyocytes from mice with a gain-of-function RyR2 mutation
CONCLUSIONS: Inhibition of CaMKII efficiently reduces spontaneous Ca2+-release, but promotes Ca2+ alternans in RyR2-R2474S cardiomyocytes with a gain-of-function RyR2 mutation. The dominant effect in RyR2-R2474S is to reduce spontaneous Ca2+-release, which supports this intervention as a therapeutic strategy in this specific condition. However, future studies on CaMKII inhibition in conditions with increased propensity for Ca2+ alternans should include investigation of both phenomena.PMID:34270372 | DOI:10.1152/ajpheart.00011.2021 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 16, 2021 Category: Physiology Authors: Mani Sadredini Marie Haugsten Hansen Michael Frisk William E Louch Stephan E Lehnart Ivar Sjaastad Mathis Korseberg Stokke Source Type: research

Angiotensin II -induced overexpression of Sirtuin-1 contributes to enhanced expression of Gi α proteins and hyperproliferation of vascular smooth muscle cells
Am J Physiol Heart Circ Physiol. 2021 Jul 16. doi: 10.1152/ajpheart.00898.2020. Online ahead of print.ABSTRACTAngiotensin II (Ang II) plays an important role in the regulation of various physiological functions including proliferation, hypertrophy of vascular smooth muscle cells (VSMC) through the overexpression of Giα proteins. Sirtuin1 (Sirt1), a class III histone deacetylase and epigenetic regulator is implicated in a wide range of cellular functions, including migration and growth of VSMC as well as in Ang II-induced hypertension. The present study was undertaken to examine the role of Sirt1 in Ang II-induced ove...
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 16, 2021 Category: Physiology Authors: Ekhtear Hossain Yuan Li Madhu B Anand-Srivastava Source Type: research

Voltage-Gated Potassium Channel Dysfunction in Dorsal Root Ganglia Contributes to the Exaggerated Exercise Pressor Reflex in Rats with Chronic Heart Failure
Am J Physiol Heart Circ Physiol. 2021 Jul 16. doi: 10.1152/ajpheart.00256.2021. Online ahead of print.ABSTRACTAn exaggerated exercise pressor reflex (EPR) causes excessive sympatho-excitation and exercise intolerance during physical activity in the chronic heart failure (CHF) state. Muscle afferent sensitization contributes to the genesis of the exaggerated EPR in CHF. However, the cellular mechanisms underlying muscle afferent sensitization in CHF remain unclear. Considering that voltage-gated potassium (Kv) channels critically regulate afferent neuronal excitability, we examined the potential role of Kv channels in media...
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 16, 2021 Category: Physiology Authors: Juan Hong Shubin Fu Lie Gao Yanhui Cai Eric D Lazartigues Han-Jun Wang Source Type: research

Mutation of the 5' untranslated region stem-loop mRNA structure reduces type I collagen deposition and arterial stiffness in male obese mice
Am J Physiol Heart Circ Physiol. 2021 Jul 9. doi: 10.1152/ajpheart.00076.2021. Online ahead of print.ABSTRACTArterial stiffening, a characteristic feature of obesity and type 2 diabetes, contributes to the development and progression of cardiovascular diseases (CVD). Currently, no effective prophylaxis or therapeutics is available to prevent or treat arterial stiffening. A better understanding of the molecular mechanisms underlying arterial stiffening is vital to identify newer targets and strategies to reduce CVD burden. A major contributor to arterial stiffening is increased collagen deposition. In the 5' untranslated re...
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 9, 2021 Category: Physiology Authors: Francisco I Ramirez-Perez Makenzie L Woodford Mariana Morales-Quinones Zachary I Grunewald Francisco J Cabral-Amador Tadashi Yoshida David A Brenner Camila Manrique-Acevedo Luis A Martinez-Lemus Bysani Chandrasekar Jaume Padilla Source Type: research

Left ventricular dyssynchrony and post-systolic shortening in young bodybuilders using anabolic-androgenic steroids
CONCLUSION: The results strongly support that the specific LV remodeling observed in young AAS users was associated with an increase in LV dyssynchrony. The correlations with ejection fraction suggested that wasted energy, due to post-systolic shortenings, contributed in part to the decrease in LV function in strength-trained athletes using AAS.PMID:34242095 | DOI:10.1152/ajpheart.00136.2021 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 9, 2021 Category: Physiology Authors: Antoine Grandperrin Iris Schuster Thomas Rupp Omar Izem Philippe Obert St éphane Nottin Source Type: research

Mutation of the 5' untranslated region stem-loop mRNA structure reduces type I collagen deposition and arterial stiffness in male obese mice
Am J Physiol Heart Circ Physiol. 2021 Jul 9. doi: 10.1152/ajpheart.00076.2021. Online ahead of print.ABSTRACTArterial stiffening, a characteristic feature of obesity and type 2 diabetes, contributes to the development and progression of cardiovascular diseases (CVD). Currently, no effective prophylaxis or therapeutics is available to prevent or treat arterial stiffening. A better understanding of the molecular mechanisms underlying arterial stiffening is vital to identify newer targets and strategies to reduce CVD burden. A major contributor to arterial stiffening is increased collagen deposition. In the 5' untranslated re...
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 9, 2021 Category: Physiology Authors: Francisco I Ramirez-Perez Makenzie L Woodford Mariana Morales-Quinones Zachary I Grunewald Francisco J Cabral-Amador Tadashi Yoshida David A Brenner Camila Manrique-Acevedo Luis A Martinez-Lemus Bysani Chandrasekar Jaume Padilla Source Type: research

Left ventricular dyssynchrony and post-systolic shortening in young bodybuilders using anabolic-androgenic steroids
CONCLUSION: The results strongly support that the specific LV remodeling observed in young AAS users was associated with an increase in LV dyssynchrony. The correlations with ejection fraction suggested that wasted energy, due to post-systolic shortenings, contributed in part to the decrease in LV function in strength-trained athletes using AAS.PMID:34242095 | DOI:10.1152/ajpheart.00136.2021 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 9, 2021 Category: Physiology Authors: Antoine Grandperrin Iris Schuster Thomas Rupp Omar Izem Philippe Obert St éphane Nottin Source Type: research

Mutation of the 5' untranslated region stem-loop mRNA structure reduces type I collagen deposition and arterial stiffness in male obese mice
Am J Physiol Heart Circ Physiol. 2021 Jul 9. doi: 10.1152/ajpheart.00076.2021. Online ahead of print.ABSTRACTArterial stiffening, a characteristic feature of obesity and type 2 diabetes, contributes to the development and progression of cardiovascular diseases (CVD). Currently, no effective prophylaxis or therapeutics is available to prevent or treat arterial stiffening. A better understanding of the molecular mechanisms underlying arterial stiffening is vital to identify newer targets and strategies to reduce CVD burden. A major contributor to arterial stiffening is increased collagen deposition. In the 5' untranslated re...
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 9, 2021 Category: Physiology Authors: Francisco I Ramirez-Perez Makenzie L Woodford Mariana Morales-Quinones Zachary I Grunewald Francisco J Cabral-Amador Tadashi Yoshida David A Brenner Camila Manrique-Acevedo Luis A Martinez-Lemus Bysani Chandrasekar Jaume Padilla Source Type: research

Left ventricular dyssynchrony and post-systolic shortening in young bodybuilders using anabolic-androgenic steroids
CONCLUSION: The results strongly support that the specific LV remodeling observed in young AAS users was associated with an increase in LV dyssynchrony. The correlations with ejection fraction suggested that wasted energy, due to post-systolic shortenings, contributed in part to the decrease in LV function in strength-trained athletes using AAS.PMID:34242095 | DOI:10.1152/ajpheart.00136.2021 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 9, 2021 Category: Physiology Authors: Antoine Grandperrin Iris Schuster Thomas Rupp Omar Izem Philippe Obert St éphane Nottin Source Type: research

Mutation of the 5' untranslated region stem-loop mRNA structure reduces type I collagen deposition and arterial stiffness in male obese mice
Am J Physiol Heart Circ Physiol. 2021 Jul 9. doi: 10.1152/ajpheart.00076.2021. Online ahead of print.ABSTRACTArterial stiffening, a characteristic feature of obesity and type 2 diabetes, contributes to the development and progression of cardiovascular diseases (CVD). Currently, no effective prophylaxis or therapeutics is available to prevent or treat arterial stiffening. A better understanding of the molecular mechanisms underlying arterial stiffening is vital to identify newer targets and strategies to reduce CVD burden. A major contributor to arterial stiffening is increased collagen deposition. In the 5' untranslated re...
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 9, 2021 Category: Physiology Authors: Francisco I Ramirez-Perez Makenzie L Woodford Mariana Morales-Quinones Zachary I Grunewald Francisco J Cabral-Amador Tadashi Yoshida David A Brenner Camila Manrique-Acevedo Luis A Martinez-Lemus Bysani Chandrasekar Jaume Padilla Source Type: research

Left ventricular dyssynchrony and post-systolic shortening in young bodybuilders using anabolic-androgenic steroids
CONCLUSION: The results strongly support that the specific LV remodeling observed in young AAS users was associated with an increase in LV dyssynchrony. The correlations with ejection fraction suggested that wasted energy, due to post-systolic shortenings, contributed in part to the decrease in LV function in strength-trained athletes using AAS.PMID:34242095 | DOI:10.1152/ajpheart.00136.2021 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 9, 2021 Category: Physiology Authors: Antoine Grandperrin Iris Schuster Thomas Rupp Omar Izem Philippe Obert St éphane Nottin Source Type: research

Mutation of the 5' untranslated region stem-loop mRNA structure reduces type I collagen deposition and arterial stiffness in male obese mice
Am J Physiol Heart Circ Physiol. 2021 Jul 9. doi: 10.1152/ajpheart.00076.2021. Online ahead of print.ABSTRACTArterial stiffening, a characteristic feature of obesity and type 2 diabetes, contributes to the development and progression of cardiovascular diseases (CVD). Currently, no effective prophylaxis or therapeutics is available to prevent or treat arterial stiffening. A better understanding of the molecular mechanisms underlying arterial stiffening is vital to identify newer targets and strategies to reduce CVD burden. A major contributor to arterial stiffening is increased collagen deposition. In the 5' untranslated re...
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 9, 2021 Category: Physiology Authors: Francisco I Ramirez-Perez Makenzie L Woodford Mariana Morales-Quinones Zachary I Grunewald Francisco J Cabral-Amador Tadashi Yoshida David A Brenner Camila Manrique-Acevedo Luis A Martinez-Lemus Bysani Chandrasekar Jaume Padilla Source Type: research

Left ventricular dyssynchrony and post-systolic shortening in young bodybuilders using anabolic-androgenic steroids
CONCLUSION: The results strongly support that the specific LV remodeling observed in young AAS users was associated with an increase in LV dyssynchrony. The correlations with ejection fraction suggested that wasted energy, due to post-systolic shortenings, contributed in part to the decrease in LV function in strength-trained athletes using AAS.PMID:34242095 | DOI:10.1152/ajpheart.00136.2021 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 9, 2021 Category: Physiology Authors: Antoine Grandperrin Iris Schuster Thomas Rupp Omar Izem Philippe Obert St éphane Nottin Source Type: research

Mutation of the 5' untranslated region stem-loop mRNA structure reduces type I collagen deposition and arterial stiffness in male obese mice
Am J Physiol Heart Circ Physiol. 2021 Jul 9. doi: 10.1152/ajpheart.00076.2021. Online ahead of print.ABSTRACTArterial stiffening, a characteristic feature of obesity and type 2 diabetes, contributes to the development and progression of cardiovascular diseases (CVD). Currently, no effective prophylaxis or therapeutics is available to prevent or treat arterial stiffening. A better understanding of the molecular mechanisms underlying arterial stiffening is vital to identify newer targets and strategies to reduce CVD burden. A major contributor to arterial stiffening is increased collagen deposition. In the 5' untranslated re...
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 9, 2021 Category: Physiology Authors: Francisco I Ramirez-Perez Makenzie L Woodford Mariana Morales-Quinones Zachary I Grunewald Francisco J Cabral-Amador Tadashi Yoshida David A Brenner Camila Manrique-Acevedo Luis A Martinez-Lemus Bysani Chandrasekar Jaume Padilla Source Type: research

Left ventricular dyssynchrony and post-systolic shortening in young bodybuilders using anabolic-androgenic steroids
CONCLUSION: The results strongly support that the specific LV remodeling observed in young AAS users was associated with an increase in LV dyssynchrony. The correlations with ejection fraction suggested that wasted energy, due to post-systolic shortenings, contributed in part to the decrease in LV function in strength-trained athletes using AAS.PMID:34242095 | DOI:10.1152/ajpheart.00136.2021 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 9, 2021 Category: Physiology Authors: Antoine Grandperrin Iris Schuster Thomas Rupp Omar Izem Philippe Obert St éphane Nottin Source Type: research

Vascular complications from SARS-CoV2: a unique finding or a common feature of viral infections?
Am J Physiol Heart Circ Physiol. 2021 Jul 1;321(1):H253. doi: 10.1152/ajpheart.00249.2021.NO ABSTRACTPMID:34233135 | DOI:10.1152/ajpheart.00249.2021 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 7, 2021 Category: Physiology Authors: Igor Vaz Source Type: research

Reply to Vaz
Am J Physiol Heart Circ Physiol. 2021 Jul 1;321(1):H254-H255. doi: 10.1152/ajpheart.00325.2021.NO ABSTRACTPMID:34233136 | DOI:10.1152/ajpheart.00325.2021 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 7, 2021 Category: Physiology Authors: Abigail S L Stickford Jonathon L Stickford Stephen M Ratchford Source Type: research

Vascular complications from SARS-CoV2: a unique finding or a common feature of viral infections?
Am J Physiol Heart Circ Physiol. 2021 Jul 1;321(1):H253. doi: 10.1152/ajpheart.00249.2021.NO ABSTRACTPMID:34233135 | DOI:10.1152/ajpheart.00249.2021 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 7, 2021 Category: Physiology Authors: Igor Vaz Source Type: research

Reply to Vaz
Am J Physiol Heart Circ Physiol. 2021 Jul 1;321(1):H254-H255. doi: 10.1152/ajpheart.00325.2021.NO ABSTRACTPMID:34233136 | DOI:10.1152/ajpheart.00325.2021 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 7, 2021 Category: Physiology Authors: Abigail S L Stickford Jonathon L Stickford Stephen M Ratchford Source Type: research

On the assessment of arterial compliance from carotid pressure waveform
Am J Physiol Heart Circ Physiol. 2021 Jul 2. doi: 10.1152/ajpheart.00241.2021. Online ahead of print.ABSTRACTIn a progressively aging population, it is of utmost importance to develop reliable, noninvasive, and cost-effective tools to estimate biomarkers which can be indicative of cardiovascular risk. Various pathophysiological conditions are associated to changes in the total arterial compliance (CT), and thus its estimation via an accurate and simple method is valuable.Direct noninvasive measurement of CT is not feasible in the clinical practice. Previous methods exist for indirect estimation of CT, which, however, requi...
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 2, 2021 Category: Physiology Authors: Vasiliki Bikia Patrick Segers Georgios Rovas Stamatia Pagoulatou Nikos Stergiopulos Source Type: research

A Novel Metric Linking Stellate Ganglion Neuronal Population Dynamics to Cardiopulmonary Physiology
CONCLUSIONS: Stellate ganglion neuronal populations exhibit cardiopulmonary integration and profound specificity toward the near-peak systolic phase of the cardiac cycle. This novel approach provides practically deployable tools to probe stellate ganglion function and its relationship to cardiopulmonary pathophysiology.PMID:34213390 | DOI:10.1152/ajpheart.00138.2021 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 2, 2021 Category: Physiology Authors: Koustubh B Sudarshan Yuichi Hori M Amer Swid Alexander C Karavos Christian Wooten J Andrew Armour Guy Kember Olujimi A Ajijola Source Type: research

Regional cardiac strain mapping by 4-dimensional ultrasound provides earlier detection of systolic and diastolic dysfunction
Am J Physiol Heart Circ Physiol. 2021 Jul 2. doi: 10.1152/ajpheart.00335.2021. Online ahead of print.NO ABSTRACTPMID:34213391 | DOI:10.1152/ajpheart.00335.2021 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 2, 2021 Category: Physiology Authors: Leslie M Ogilvie Bridget Coyle-Asbil Keith R Brunt Jeremy A Simpson Source Type: research

Increased hemoglobin affinity for oxygen with gbt1118 improves hypoxia tolerance in sickle cell mice
In this study, GBT1118, an analog of voxelotor, was used to assess the impact of increasing Hb affinity for O2 on brain tissue oxygenation, blood pressure, heart rate, O2 delivery, and tolerance to hypoxia in Townes transgenic SCD mice. Brain oxygenation and O2 delivery were studied during normoxia and severe hypoxic challenges. GBT1118's pharmacokinetics in SCD mice allowed it to achieve the degree of Hb modification that voxelotor targets clinically. Chronic treatment with GBT1118 increased Hb affinity for O2, reducing the PO2 for 50% Hb O2 saturation (P50) in SCD mice from 31 mmHg to 18 mmHg. Chronic treatment with GBT1...
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 2, 2021 Category: Physiology Authors: Kobina Dufu Alexander T Williams Cynthia R Rodrigues Muller Cynthia M Walser Alfredo Lucas Allyn M Eaker Carsten Alt Brian E Cathers Donna Oksenberg Pedro Cabrales Source Type: research

A novel system for mapping regional electrical properties and characterizing arrhythmia in isolated intact rat atria
CONCLUSION: Our new methodology provides a robust means of 1) quantifying regional electrical properties in the intact rat atria at higher spatio-temporal resolution than previously reported, and 2) characterizing reentrant arrhythmia and analyzing mechanisms that give rise to it.PMID:34213393 | DOI:10.1152/ajpheart.00185.2021 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 2, 2021 Category: Physiology Authors: Girish S Ramlugun Gregory B Sands Jichao Zhao Ian J LeGrice Bruce H Smaill Source Type: research

On the assessment of arterial compliance from carotid pressure waveform
Am J Physiol Heart Circ Physiol. 2021 Jul 2. doi: 10.1152/ajpheart.00241.2021. Online ahead of print.ABSTRACTIn a progressively aging population, it is of utmost importance to develop reliable, noninvasive, and cost-effective tools to estimate biomarkers which can be indicative of cardiovascular risk. Various pathophysiological conditions are associated to changes in the total arterial compliance (CT), and thus its estimation via an accurate and simple method is valuable.Direct noninvasive measurement of CT is not feasible in the clinical practice. Previous methods exist for indirect estimation of CT, which, however, requi...
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 2, 2021 Category: Physiology Authors: Vasiliki Bikia Patrick Segers Georgios Rovas Stamatia Pagoulatou Nikos Stergiopulos Source Type: research

A Novel Metric Linking Stellate Ganglion Neuronal Population Dynamics to Cardiopulmonary Physiology
CONCLUSIONS: Stellate ganglion neuronal populations exhibit cardiopulmonary integration and profound specificity toward the near-peak systolic phase of the cardiac cycle. This novel approach provides practically deployable tools to probe stellate ganglion function and its relationship to cardiopulmonary pathophysiology.PMID:34213390 | DOI:10.1152/ajpheart.00138.2021 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 2, 2021 Category: Physiology Authors: Koustubh B Sudarshan Yuichi Hori M Amer Swid Alexander C Karavos Christian Wooten J Andrew Armour Guy Kember Olujimi A Ajijola Source Type: research

Regional cardiac strain mapping by 4-dimensional ultrasound provides earlier detection of systolic and diastolic dysfunction
Am J Physiol Heart Circ Physiol. 2021 Jul 2. doi: 10.1152/ajpheart.00335.2021. Online ahead of print.NO ABSTRACTPMID:34213391 | DOI:10.1152/ajpheart.00335.2021 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 2, 2021 Category: Physiology Authors: Leslie M Ogilvie Bridget Coyle-Asbil Keith R Brunt Jeremy A Simpson Source Type: research

Increased hemoglobin affinity for oxygen with gbt1118 improves hypoxia tolerance in sickle cell mice
In this study, GBT1118, an analog of voxelotor, was used to assess the impact of increasing Hb affinity for O2 on brain tissue oxygenation, blood pressure, heart rate, O2 delivery, and tolerance to hypoxia in Townes transgenic SCD mice. Brain oxygenation and O2 delivery were studied during normoxia and severe hypoxic challenges. GBT1118's pharmacokinetics in SCD mice allowed it to achieve the degree of Hb modification that voxelotor targets clinically. Chronic treatment with GBT1118 increased Hb affinity for O2, reducing the PO2 for 50% Hb O2 saturation (P50) in SCD mice from 31 mmHg to 18 mmHg. Chronic treatment with GBT1...
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 2, 2021 Category: Physiology Authors: Kobina Dufu Alexander T Williams Cynthia R Rodrigues Muller Cynthia M Walser Alfredo Lucas Allyn M Eaker Carsten Alt Brian E Cathers Donna Oksenberg Pedro Cabrales Source Type: research

A novel system for mapping regional electrical properties and characterizing arrhythmia in isolated intact rat atria
CONCLUSION: Our new methodology provides a robust means of 1) quantifying regional electrical properties in the intact rat atria at higher spatio-temporal resolution than previously reported, and 2) characterizing reentrant arrhythmia and analyzing mechanisms that give rise to it.PMID:34213393 | DOI:10.1152/ajpheart.00185.2021 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 2, 2021 Category: Physiology Authors: Girish S Ramlugun Gregory B Sands Jichao Zhao Ian J LeGrice Bruce H Smaill Source Type: research

On the assessment of arterial compliance from carotid pressure waveform
Am J Physiol Heart Circ Physiol. 2021 Jul 2. doi: 10.1152/ajpheart.00241.2021. Online ahead of print.ABSTRACTIn a progressively aging population, it is of utmost importance to develop reliable, noninvasive, and cost-effective tools to estimate biomarkers which can be indicative of cardiovascular risk. Various pathophysiological conditions are associated to changes in the total arterial compliance (CT), and thus its estimation via an accurate and simple method is valuable.Direct noninvasive measurement of CT is not feasible in the clinical practice. Previous methods exist for indirect estimation of CT, which, however, requi...
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 2, 2021 Category: Physiology Authors: Vasiliki Bikia Patrick Segers Georgios Rovas Stamatia Pagoulatou Nikos Stergiopulos Source Type: research

A Novel Metric Linking Stellate Ganglion Neuronal Population Dynamics to Cardiopulmonary Physiology
CONCLUSIONS: Stellate ganglion neuronal populations exhibit cardiopulmonary integration and profound specificity toward the near-peak systolic phase of the cardiac cycle. This novel approach provides practically deployable tools to probe stellate ganglion function and its relationship to cardiopulmonary pathophysiology.PMID:34213390 | DOI:10.1152/ajpheart.00138.2021 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 2, 2021 Category: Physiology Authors: Koustubh B Sudarshan Yuichi Hori M Amer Swid Alexander C Karavos Christian Wooten J Andrew Armour Guy Kember Olujimi A Ajijola Source Type: research