Fibroblast Growth Factor 23 (FGF23) Induces Ventricular Arrhythmias and Prolongs QTc Interval in Mice in an FGF Receptor 4-Dependent Manner
Am J Physiol Heart Circ Physiol. 2021 Apr 30. doi: 10.1152/ajpheart.00798.2020. Online ahead of print.ABSTRACTFibroblast growth factor 23 (FGF23) is a phosphate regulating protein hormone released by osteocytes. FGF23 becomes markedly elevated in chronic kidney disease (CKD), for which the leading cause of death is cardiovascular disease, particularly sudden cardiac death. Previously, we found that FGF23 increases intracellular Ca2+ in cardiomyocytes and alters contractility in mouse ventricles ex vivo via FGF-receptor 4 (FGFR4). In the present study, we demonstrate that FGF23 induces cardiac arrhythmias and prolongs QTc i...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 30, 2021 Category: Physiology Authors: Jonah M Graves Julian A Vallejo Chelsea S Hamill Derek Wang Rohan Ahuja Shaan Patel Christian Faul Michael J Wacker Source Type: research

Deficiency of Ataxia-Telangiectasia Mutated Kinase Modulates Functional and Biochemical Parameters of the Heart in Response to Western-type Diet
Am J Physiol Heart Circ Physiol. 2021 Apr 30. doi: 10.1152/ajpheart.00990.2020. Online ahead of print.ABSTRACTAtaxia telangiectasia mutated kinase (ATM) deficiency exacerbates heart dysfunction late after myocardial infarction. Here, we hypothesized that ATM deficiency modulates Western-type diet (WD)-induced cardiac remodeling with an emphasis on functional and biochemical parameters of the heart. Weight gain was assessed in male wild-type (WT) and ATM heterozygous knockout (hKO) mice on weekly basis, while cardiac functional and biochemical parameters were measured 14 weeks post-WD. hKO-WD mice exhibited rapid body weigh...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 30, 2021 Category: Physiology Authors: Mary C Wingard Suman Dalal Paige L Shook Rachel Myers Barbara A Connelly Douglas P Thewke Mahipal Singh Krishna Singh Source Type: research

Male and Female High Fat Fed Dahl SS rats are largely protected from vascular dysfunctions: PVAT contributions reveal sex differences
Am J Physiol Heart Circ Physiol. 2021 Apr 30. doi: 10.1152/ajpheart.00131.2021. Online ahead of print.ABSTRACTVascular dysfunctions are observed in arteries from hypertensive subjects. The establishment of the Dahl SS male and female rat model to develop a reproducible hypertension with high fat (HF) diet feeding from weaning allows addressing the question of whether HF-diet associated hypertension results in vascular dysfunction similar to that of essential hypertension in both sexes. We hypothesized that dysfunction of three distinct vascular layers -- endothelial, smooth muscle and perivascular adipose tissue (PVAT) -- ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 30, 2021 Category: Physiology Authors: Stephanie W Watts Emma S Darios G Andres Contreras Hannah Garver Gregory D Fink Source Type: research

Barth Syndrome-Related Cardiomyopathy is Associated with a Reduction in Myocardial Glucose Oxidation
Am J Physiol Heart Circ Physiol. 2021 Apr 30. doi: 10.1152/ajpheart.00873.2020. Online ahead of print.ABSTRACTHeart failure presents as the leading cause of infant mortality in individuals with Barth syndrome (BTHS), a rare genetic disorder due to mutations in the tafazzin (TAZ) gene affecting mitochondrial structure and function. Investigations into the perturbed bioenergetics in the BTHS heart remain limited. Hence, our objective was to identify the potential alterations in myocardial energy metabolism and molecular underpinnings that may contribute to the early cardiomyopathy and heart failure development in BTHS. Cardi...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 30, 2021 Category: Physiology Authors: Amanda A Greenwell Keshav Gopal Tariq Altamimi Christina T Saed Faqi Wang Seyed Amirhossein Tabatabaei-Dakhili Kim L Ho Liyan Zhang Farah Eaton Jennifer L Kruger Rami Al Batran Gary D Lopaschuk Gavin Y Oudit John R Ussher Source Type: research

Fibroblast Growth Factor 23 (FGF23) Induces Ventricular Arrhythmias and Prolongs QTc Interval in Mice in an FGF Receptor 4-Dependent Manner
Am J Physiol Heart Circ Physiol. 2021 Apr 30. doi: 10.1152/ajpheart.00798.2020. Online ahead of print.ABSTRACTFibroblast growth factor 23 (FGF23) is a phosphate regulating protein hormone released by osteocytes. FGF23 becomes markedly elevated in chronic kidney disease (CKD), for which the leading cause of death is cardiovascular disease, particularly sudden cardiac death. Previously, we found that FGF23 increases intracellular Ca2+ in cardiomyocytes and alters contractility in mouse ventricles ex vivo via FGF-receptor 4 (FGFR4). In the present study, we demonstrate that FGF23 induces cardiac arrhythmias and prolongs QTc i...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 30, 2021 Category: Physiology Authors: Jonah M Graves Julian A Vallejo Chelsea S Hamill Derek Wang Rohan Ahuja Shaan Patel Christian Faul Michael J Wacker Source Type: research

Deficiency of Ataxia-Telangiectasia Mutated Kinase Modulates Functional and Biochemical Parameters of the Heart in Response to Western-type Diet
Am J Physiol Heart Circ Physiol. 2021 Apr 30. doi: 10.1152/ajpheart.00990.2020. Online ahead of print.ABSTRACTAtaxia telangiectasia mutated kinase (ATM) deficiency exacerbates heart dysfunction late after myocardial infarction. Here, we hypothesized that ATM deficiency modulates Western-type diet (WD)-induced cardiac remodeling with an emphasis on functional and biochemical parameters of the heart. Weight gain was assessed in male wild-type (WT) and ATM heterozygous knockout (hKO) mice on weekly basis, while cardiac functional and biochemical parameters were measured 14 weeks post-WD. hKO-WD mice exhibited rapid body weigh...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 30, 2021 Category: Physiology Authors: Mary C Wingard Suman Dalal Paige L Shook Rachel Myers Barbara A Connelly Douglas P Thewke Mahipal Singh Krishna Singh Source Type: research

Male and Female High Fat Fed Dahl SS rats are largely protected from vascular dysfunctions: PVAT contributions reveal sex differences
Am J Physiol Heart Circ Physiol. 2021 Apr 30. doi: 10.1152/ajpheart.00131.2021. Online ahead of print.ABSTRACTVascular dysfunctions are observed in arteries from hypertensive subjects. The establishment of the Dahl SS male and female rat model to develop a reproducible hypertension with high fat (HF) diet feeding from weaning allows addressing the question of whether HF-diet associated hypertension results in vascular dysfunction similar to that of essential hypertension in both sexes. We hypothesized that dysfunction of three distinct vascular layers -- endothelial, smooth muscle and perivascular adipose tissue (PVAT) -- ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 30, 2021 Category: Physiology Authors: Stephanie W Watts Emma S Darios G Andres Contreras Hannah Garver Gregory D Fink Source Type: research

Barth Syndrome-Related Cardiomyopathy is Associated with a Reduction in Myocardial Glucose Oxidation
Am J Physiol Heart Circ Physiol. 2021 Apr 30. doi: 10.1152/ajpheart.00873.2020. Online ahead of print.ABSTRACTHeart failure presents as the leading cause of infant mortality in individuals with Barth syndrome (BTHS), a rare genetic disorder due to mutations in the tafazzin (TAZ) gene affecting mitochondrial structure and function. Investigations into the perturbed bioenergetics in the BTHS heart remain limited. Hence, our objective was to identify the potential alterations in myocardial energy metabolism and molecular underpinnings that may contribute to the early cardiomyopathy and heart failure development in BTHS. Cardi...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 30, 2021 Category: Physiology Authors: Amanda A Greenwell Keshav Gopal Tariq Altamimi Christina T Saed Faqi Wang Seyed Amirhossein Tabatabaei-Dakhili Kim L Ho Liyan Zhang Farah Eaton Jennifer L Kruger Rami Al Batran Gary D Lopaschuk Gavin Y Oudit John R Ussher Source Type: research

Fibroblast Growth Factor 23 (FGF23) Induces Ventricular Arrhythmias and Prolongs QTc Interval in Mice in an FGF Receptor 4-Dependent Manner
Am J Physiol Heart Circ Physiol. 2021 Apr 30. doi: 10.1152/ajpheart.00798.2020. Online ahead of print.ABSTRACTFibroblast growth factor 23 (FGF23) is a phosphate regulating protein hormone released by osteocytes. FGF23 becomes markedly elevated in chronic kidney disease (CKD), for which the leading cause of death is cardiovascular disease, particularly sudden cardiac death. Previously, we found that FGF23 increases intracellular Ca2+ in cardiomyocytes and alters contractility in mouse ventricles ex vivo via FGF-receptor 4 (FGFR4). In the present study, we demonstrate that FGF23 induces cardiac arrhythmias and prolongs QTc i...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 30, 2021 Category: Physiology Authors: Jonah M Graves Julian A Vallejo Chelsea S Hamill Derek Wang Rohan Ahuja Shaan Patel Christian Faul Michael J Wacker Source Type: research

Deficiency of Ataxia-Telangiectasia Mutated Kinase Modulates Functional and Biochemical Parameters of the Heart in Response to Western-type Diet
Am J Physiol Heart Circ Physiol. 2021 Apr 30. doi: 10.1152/ajpheart.00990.2020. Online ahead of print.ABSTRACTAtaxia telangiectasia mutated kinase (ATM) deficiency exacerbates heart dysfunction late after myocardial infarction. Here, we hypothesized that ATM deficiency modulates Western-type diet (WD)-induced cardiac remodeling with an emphasis on functional and biochemical parameters of the heart. Weight gain was assessed in male wild-type (WT) and ATM heterozygous knockout (hKO) mice on weekly basis, while cardiac functional and biochemical parameters were measured 14 weeks post-WD. hKO-WD mice exhibited rapid body weigh...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 30, 2021 Category: Physiology Authors: Mary C Wingard Suman Dalal Paige L Shook Rachel Myers Barbara A Connelly Douglas P Thewke Mahipal Singh Krishna Singh Source Type: research

Male and Female High Fat Fed Dahl SS rats are largely protected from vascular dysfunctions: PVAT contributions reveal sex differences
Am J Physiol Heart Circ Physiol. 2021 Apr 30. doi: 10.1152/ajpheart.00131.2021. Online ahead of print.ABSTRACTVascular dysfunctions are observed in arteries from hypertensive subjects. The establishment of the Dahl SS male and female rat model to develop a reproducible hypertension with high fat (HF) diet feeding from weaning allows addressing the question of whether HF-diet associated hypertension results in vascular dysfunction similar to that of essential hypertension in both sexes. We hypothesized that dysfunction of three distinct vascular layers -- endothelial, smooth muscle and perivascular adipose tissue (PVAT) -- ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 30, 2021 Category: Physiology Authors: Stephanie W Watts Emma S Darios G Andres Contreras Hannah Garver Gregory D Fink Source Type: research

Barth Syndrome-Related Cardiomyopathy is Associated with a Reduction in Myocardial Glucose Oxidation
Am J Physiol Heart Circ Physiol. 2021 Apr 30. doi: 10.1152/ajpheart.00873.2020. Online ahead of print.ABSTRACTHeart failure presents as the leading cause of infant mortality in individuals with Barth syndrome (BTHS), a rare genetic disorder due to mutations in the tafazzin (TAZ) gene affecting mitochondrial structure and function. Investigations into the perturbed bioenergetics in the BTHS heart remain limited. Hence, our objective was to identify the potential alterations in myocardial energy metabolism and molecular underpinnings that may contribute to the early cardiomyopathy and heart failure development in BTHS. Cardi...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 30, 2021 Category: Physiology Authors: Amanda A Greenwell Keshav Gopal Tariq Altamimi Christina T Saed Faqi Wang Seyed Amirhossein Tabatabaei-Dakhili Kim L Ho Liyan Zhang Farah Eaton Jennifer L Kruger Rami Al Batran Gary D Lopaschuk Gavin Y Oudit John R Ussher Source Type: research

Find the Stimulus, Save the Heart: A Heroes Story
Am J Physiol Heart Circ Physiol. 2021 Apr 23. doi: 10.1152/ajpheart.00194.2021. Online ahead of print.NO ABSTRACTPMID:33891514 | DOI:10.1152/ajpheart.00194.2021 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 23, 2021 Category: Physiology Authors: Baylee Westbury Dawson Bolus Kristine Y DeLeon-Pennell Source Type: research

Ivabradine augments high-frequency dynamic gain of the heart rate response to low- and moderate-intensity vagal nerve stimulation under beta-blockade
Am J Physiol Heart Circ Physiol. 2021 Apr 23. doi: 10.1152/ajpheart.00057.2021. Online ahead of print.ABSTRACTOur previous study indicated that intravenously administered ivabradine (IVA) augmented the dynamic heart rate (HR) response to moderate-intensity vagal nerve stimulation (VNS). Considering an accentuated antagonism, the results were somewhat paradoxical; i.e., the accentuated antagonism indicates that an activation of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels via the accumulation of intracellular cyclic adenosine monophosphate (cAMP) augments the HR response to VNS, whereas the inhibition ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 23, 2021 Category: Physiology Authors: Toru Kawada Hiromi Yamamoto Kazunori Uemura Yohsuke Hayama Takuya Nishikawa Can Zheng Meihua Li Tadayoshi Miyamoto Masaru Sugimachi Source Type: research

Find the Stimulus, Save the Heart: A Heroes Story
Am J Physiol Heart Circ Physiol. 2021 Apr 23. doi: 10.1152/ajpheart.00194.2021. Online ahead of print.NO ABSTRACTPMID:33891514 | DOI:10.1152/ajpheart.00194.2021 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 23, 2021 Category: Physiology Authors: Baylee Westbury Dawson Bolus Kristine Y DeLeon-Pennell Source Type: research

Ivabradine augments high-frequency dynamic gain of the heart rate response to low- and moderate-intensity vagal nerve stimulation under beta-blockade
Am J Physiol Heart Circ Physiol. 2021 Apr 23. doi: 10.1152/ajpheart.00057.2021. Online ahead of print.ABSTRACTOur previous study indicated that intravenously administered ivabradine (IVA) augmented the dynamic heart rate (HR) response to moderate-intensity vagal nerve stimulation (VNS). Considering an accentuated antagonism, the results were somewhat paradoxical; i.e., the accentuated antagonism indicates that an activation of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels via the accumulation of intracellular cyclic adenosine monophosphate (cAMP) augments the HR response to VNS, whereas the inhibition ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 23, 2021 Category: Physiology Authors: Toru Kawada Hiromi Yamamoto Kazunori Uemura Yohsuke Hayama Takuya Nishikawa Can Zheng Meihua Li Tadayoshi Miyamoto Masaru Sugimachi Source Type: research

Find the Stimulus, Save the Heart: A Heroes Story
Am J Physiol Heart Circ Physiol. 2021 Apr 23. doi: 10.1152/ajpheart.00194.2021. Online ahead of print.NO ABSTRACTPMID:33891514 | DOI:10.1152/ajpheart.00194.2021 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 23, 2021 Category: Physiology Authors: Baylee Westbury Dawson Bolus Kristine Y DeLeon-Pennell Source Type: research

Ivabradine augments high-frequency dynamic gain of the heart rate response to low- and moderate-intensity vagal nerve stimulation under beta-blockade
Am J Physiol Heart Circ Physiol. 2021 Apr 23. doi: 10.1152/ajpheart.00057.2021. Online ahead of print.ABSTRACTOur previous study indicated that intravenously administered ivabradine (IVA) augmented the dynamic heart rate (HR) response to moderate-intensity vagal nerve stimulation (VNS). Considering an accentuated antagonism, the results were somewhat paradoxical; i.e., the accentuated antagonism indicates that an activation of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels via the accumulation of intracellular cyclic adenosine monophosphate (cAMP) augments the HR response to VNS, whereas the inhibition ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 23, 2021 Category: Physiology Authors: Toru Kawada Hiromi Yamamoto Kazunori Uemura Yohsuke Hayama Takuya Nishikawa Can Zheng Meihua Li Tadayoshi Miyamoto Masaru Sugimachi Source Type: research

Find the Stimulus, Save the Heart: A Heroes Story
Am J Physiol Heart Circ Physiol. 2021 Apr 23. doi: 10.1152/ajpheart.00194.2021. Online ahead of print.NO ABSTRACTPMID:33891514 | DOI:10.1152/ajpheart.00194.2021 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 23, 2021 Category: Physiology Authors: Baylee Westbury Dawson Bolus Kristine Y DeLeon-Pennell Source Type: research

Ivabradine augments high-frequency dynamic gain of the heart rate response to low- and moderate-intensity vagal nerve stimulation under beta-blockade
Am J Physiol Heart Circ Physiol. 2021 Apr 23. doi: 10.1152/ajpheart.00057.2021. Online ahead of print.ABSTRACTOur previous study indicated that intravenously administered ivabradine (IVA) augmented the dynamic heart rate (HR) response to moderate-intensity vagal nerve stimulation (VNS). Considering an accentuated antagonism, the results were somewhat paradoxical; i.e., the accentuated antagonism indicates that an activation of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels via the accumulation of intracellular cyclic adenosine monophosphate (cAMP) augments the HR response to VNS, whereas the inhibition ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 23, 2021 Category: Physiology Authors: Toru Kawada Hiromi Yamamoto Kazunori Uemura Yohsuke Hayama Takuya Nishikawa Can Zheng Meihua Li Tadayoshi Miyamoto Masaru Sugimachi Source Type: research

Find the Stimulus, Save the Heart: A Heroes Story
Am J Physiol Heart Circ Physiol. 2021 Apr 23. doi: 10.1152/ajpheart.00194.2021. Online ahead of print.NO ABSTRACTPMID:33891514 | DOI:10.1152/ajpheart.00194.2021 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 23, 2021 Category: Physiology Authors: Baylee Westbury Dawson Bolus Kristine Y DeLeon-Pennell Source Type: research

Ivabradine augments high-frequency dynamic gain of the heart rate response to low- and moderate-intensity vagal nerve stimulation under beta-blockade
Am J Physiol Heart Circ Physiol. 2021 Apr 23. doi: 10.1152/ajpheart.00057.2021. Online ahead of print.ABSTRACTOur previous study indicated that intravenously administered ivabradine (IVA) augmented the dynamic heart rate (HR) response to moderate-intensity vagal nerve stimulation (VNS). Considering an accentuated antagonism, the results were somewhat paradoxical; i.e., the accentuated antagonism indicates that an activation of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels via the accumulation of intracellular cyclic adenosine monophosphate (cAMP) augments the HR response to VNS, whereas the inhibition ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 23, 2021 Category: Physiology Authors: Toru Kawada Hiromi Yamamoto Kazunori Uemura Yohsuke Hayama Takuya Nishikawa Can Zheng Meihua Li Tadayoshi Miyamoto Masaru Sugimachi Source Type: research

Find the Stimulus, Save the Heart: A Heroes Story
Am J Physiol Heart Circ Physiol. 2021 Apr 23. doi: 10.1152/ajpheart.00194.2021. Online ahead of print.NO ABSTRACTPMID:33891514 | DOI:10.1152/ajpheart.00194.2021 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 23, 2021 Category: Physiology Authors: Baylee Westbury Dawson Bolus Kristine Y DeLeon-Pennell Source Type: research

Ivabradine augments high-frequency dynamic gain of the heart rate response to low- and moderate-intensity vagal nerve stimulation under beta-blockade
Am J Physiol Heart Circ Physiol. 2021 Apr 23. doi: 10.1152/ajpheart.00057.2021. Online ahead of print.ABSTRACTOur previous study indicated that intravenously administered ivabradine (IVA) augmented the dynamic heart rate (HR) response to moderate-intensity vagal nerve stimulation (VNS). Considering an accentuated antagonism, the results were somewhat paradoxical; i.e., the accentuated antagonism indicates that an activation of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels via the accumulation of intracellular cyclic adenosine monophosphate (cAMP) augments the HR response to VNS, whereas the inhibition ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 23, 2021 Category: Physiology Authors: Toru Kawada Hiromi Yamamoto Kazunori Uemura Yohsuke Hayama Takuya Nishikawa Can Zheng Meihua Li Tadayoshi Miyamoto Masaru Sugimachi Source Type: research

Serca2a-Phospholamban Interaction Monitored by an Interposed Circularly Permutated Green Fluorescent Protein
Am J Physiol Heart Circ Physiol. 2021 Apr 16. doi: 10.1152/ajpheart.00858.2020. Online ahead of print.ABSTRACTBACKGROUND: The interaction of phospholamban (PLB) and the sarcoplasmic reticulum Ca2+-ATPase (Serca2a) is a key regulator of cardiac contractility and a therapeutic target in heart failure (HF). PLB mediated increases in Serca2a activity improve cardiac function and HF. Clinically this mechanism can only be exploited by a general activation of the proteinkinase A (PKA) which is associated with side effects and adverse clinical outcomes. A selective interference of the PLB-Serca2a interaction is desirable but will ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 16, 2021 Category: Physiology Authors: Maren E Arnold Wolfgang R Dostmann Jody Martin Michael J Previs Bradley Palmer Martin LeWinter Markus Meyer Source Type: research

Deficiency in Nebulin Repeats of Sarcomeric Nebulette is Detrimental for Cardiomyocyte Tolerance to Exercise and Biomechanical Stress
CONCLUSIONS: Upon stretch, NEBL deficiency causes disturbed sarcomere, Z-disks and desmin organization, and prevents NEBL redistribution to focal adhesions in cardiomyocytes, weakening cardiac tolerance to stress.PMID:33861145 | DOI:10.1152/ajpheart.00732.2020 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 16, 2021 Category: Physiology Authors: Ramona M Vejandla Buyan-Ochir Orgil Neely R Alberson Ning Li Undral Munkhsaikhan Zaza Khuchua Ruben Martherus Evren U Azeloglu Fuyi Xu Lu Lu Jeffrey A Towbin Enkhsaikhan Purevjav Source Type: research

Insulin Stimulation Reduces Aortic Waveform in Adults with Metabolic Syndrome
Am J Physiol Heart Circ Physiol. 2021 Apr 16. doi: 10.1152/ajpheart.00975.2020. Online ahead of print.ABSTRACTAdults with metabolic syndrome (MetS) have increased fasting arterial stiffness and altered central hemodynamics that contribute, partly, to increased cardiovascular disease (CVD) risk. Although insulin affects aortic wave reflections in healthy adults, the effects in individuals with MetS are unclear. We hypothesized that insulin stimulation would reduce measures of pressure waveforms and hemodynamics in people with MetS. Thirty-five adults with obesity (27F; 54.2 ± 6.0 yr; 37.1 ± 4.8 kg/m2) were sel...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 16, 2021 Category: Physiology Authors: Brielle L Dotson Emily M Heiston Stephanie L Miller Steven K Malin Source Type: research

A New Trick for an Old Dog? Myocardial-Specific Roles for Prostaglandins as Mediators of Ischemic Injury and Repair
Am J Physiol Heart Circ Physiol. 2021 Apr 16. doi: 10.1152/ajpheart.00872.2020. Online ahead of print.ABSTRACTThe small lipid-derived paracrine signalling molecules known as prostaglandins have been recognized for their ability to modulate many facets of cardiovascular physiology since their initial discovery more than 85 years ago. While the role of prostaglandins in the vasculature has gained significant attention across time, a handful of historical studies have also directly implicated the cardiomyocyte in both prostaglandin synthesis and release. Recently our understanding of how prostaglandin receptor modulation impa...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 16, 2021 Category: Physiology Authors: Matthew D Martens Amy S Fernando Joseph W Gordon Source Type: research

Sildenafil Administration Improves Right Ventricular Function on 4D Flow MRI in Young Adults Born Premature
Am J Physiol Heart Circ Physiol. 2021 Apr 16. doi: 10.1152/ajpheart.00824.2020. Online ahead of print.ABSTRACTBACKGROUND: Extreme preterm birth conveys an elevated risk of heart failure by young adulthood. Smaller biventricular chamber size, diastolic dysfunction, and pulmonary hypertension may contribute to reduced ventricular-vascular coupling. However, how hemodynamic manipulations may affect right ventricular (RV) function and coupling remains unknown.METHODS: As a pilot study, 4D flow MRI was used to assess the effect of afterload reduction and heart rate reduction on cardiac hemodynamics and function. Young adults bo...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 16, 2021 Category: Physiology Authors: Philip A Corrado Gregory P Barton Christopher J Fran çois Oliver Wieben Kara N Goss Source Type: research

Mesenchymal stem cell-derived extracellular vesicles in the failing heart: past, present, and future
Am J Physiol Heart Circ Physiol. 2021 Apr 16. doi: 10.1152/ajpheart.00951.2020. Online ahead of print.ABSTRACTCardiovascular disease (CVD) is the leading cause of death globally. Current treatment options include lifestyle changes, medication, and surgical intervention. However, many patients are unsuitable candidates for surgeries due to comorbidities, diffuse coronary artery disease or advanced stages of heart failure. The search for new treatment options has recently transitioned from cell-based therapies to stem-cell derived extracellular vesicles (EVs). A number of challenges remain in the EV field, including the effe...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 16, 2021 Category: Physiology Authors: Catherine Karbasiafshar Frank W Sellke M Ruhul Abid Source Type: research

Serca2a-Phospholamban Interaction Monitored by an Interposed Circularly Permutated Green Fluorescent Protein
Am J Physiol Heart Circ Physiol. 2021 Apr 16. doi: 10.1152/ajpheart.00858.2020. Online ahead of print.ABSTRACTBACKGROUND: The interaction of phospholamban (PLB) and the sarcoplasmic reticulum Ca2+-ATPase (Serca2a) is a key regulator of cardiac contractility and a therapeutic target in heart failure (HF). PLB mediated increases in Serca2a activity improve cardiac function and HF. Clinically this mechanism can only be exploited by a general activation of the proteinkinase A (PKA) which is associated with side effects and adverse clinical outcomes. A selective interference of the PLB-Serca2a interaction is desirable but will ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 16, 2021 Category: Physiology Authors: Maren E Arnold Wolfgang R Dostmann Jody Martin Michael J Previs Bradley Palmer Martin LeWinter Markus Meyer Source Type: research

Deficiency in Nebulin Repeats of Sarcomeric Nebulette is Detrimental for Cardiomyocyte Tolerance to Exercise and Biomechanical Stress
CONCLUSIONS: Upon stretch, NEBL deficiency causes disturbed sarcomere, Z-disks and desmin organization, and prevents NEBL redistribution to focal adhesions in cardiomyocytes, weakening cardiac tolerance to stress.PMID:33861145 | DOI:10.1152/ajpheart.00732.2020 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 16, 2021 Category: Physiology Authors: Ramona M Vejandla Buyan-Ochir Orgil Neely R Alberson Ning Li Undral Munkhsaikhan Zaza Khuchua Ruben Martherus Evren U Azeloglu Fuyi Xu Lu Lu Jeffrey A Towbin Enkhsaikhan Purevjav Source Type: research

Insulin Stimulation Reduces Aortic Waveform in Adults with Metabolic Syndrome
Am J Physiol Heart Circ Physiol. 2021 Apr 16. doi: 10.1152/ajpheart.00975.2020. Online ahead of print.ABSTRACTAdults with metabolic syndrome (MetS) have increased fasting arterial stiffness and altered central hemodynamics that contribute, partly, to increased cardiovascular disease (CVD) risk. Although insulin affects aortic wave reflections in healthy adults, the effects in individuals with MetS are unclear. We hypothesized that insulin stimulation would reduce measures of pressure waveforms and hemodynamics in people with MetS. Thirty-five adults with obesity (27F; 54.2 ± 6.0 yr; 37.1 ± 4.8 kg/m2) were sel...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 16, 2021 Category: Physiology Authors: Brielle L Dotson Emily M Heiston Stephanie L Miller Steven K Malin Source Type: research

A New Trick for an Old Dog? Myocardial-Specific Roles for Prostaglandins as Mediators of Ischemic Injury and Repair
Am J Physiol Heart Circ Physiol. 2021 Apr 16. doi: 10.1152/ajpheart.00872.2020. Online ahead of print.ABSTRACTThe small lipid-derived paracrine signalling molecules known as prostaglandins have been recognized for their ability to modulate many facets of cardiovascular physiology since their initial discovery more than 85 years ago. While the role of prostaglandins in the vasculature has gained significant attention across time, a handful of historical studies have also directly implicated the cardiomyocyte in both prostaglandin synthesis and release. Recently our understanding of how prostaglandin receptor modulation impa...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 16, 2021 Category: Physiology Authors: Matthew D Martens Amy S Amy Fernando Joseph W Gordon Source Type: research

Sildenafil Administration Improves Right Ventricular Function on 4D Flow MRI in Young Adults Born Premature
Am J Physiol Heart Circ Physiol. 2021 Apr 16. doi: 10.1152/ajpheart.00824.2020. Online ahead of print.ABSTRACTBACKGROUND: Extreme preterm birth conveys an elevated risk of heart failure by young adulthood. Smaller biventricular chamber size, diastolic dysfunction, and pulmonary hypertension may contribute to reduced ventricular-vascular coupling. However, how hemodynamic manipulations may affect right ventricular (RV) function and coupling remains unknown.METHODS: As a pilot study, 4D flow MRI was used to assess the effect of afterload reduction and heart rate reduction on cardiac hemodynamics and function. Young adults bo...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 16, 2021 Category: Physiology Authors: Philip A Corrado Gregory P Barton Christopher J Fran çois Oliver Wieben Kara N Goss Source Type: research

Mesenchymal stem cell-derived extracellular vesicles in the failing heart: past, present, and future
Am J Physiol Heart Circ Physiol. 2021 Apr 16. doi: 10.1152/ajpheart.00951.2020. Online ahead of print.ABSTRACTCardiovascular disease (CVD) is the leading cause of death globally. Current treatment options include lifestyle changes, medication, and surgical intervention. However, many patients are unsuitable candidates for surgeries due to comorbidities, diffuse coronary artery disease or advanced stages of heart failure. The search for new treatment options has recently transitioned from cell-based therapies to stem-cell derived extracellular vesicles (EVs). A number of challenges remain in the EV field, including the effe...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 16, 2021 Category: Physiology Authors: Catherine Karbasiafshar Frank W Sellke M Ruhul Abid Source Type: research

Serca2a-Phospholamban Interaction Monitored by an Interposed Circularly Permutated Green Fluorescent Protein
Am J Physiol Heart Circ Physiol. 2021 Apr 16. doi: 10.1152/ajpheart.00858.2020. Online ahead of print.ABSTRACTBACKGROUND: The interaction of phospholamban (PLB) and the sarcoplasmic reticulum Ca2+-ATPase (Serca2a) is a key regulator of cardiac contractility and a therapeutic target in heart failure (HF). PLB mediated increases in Serca2a activity improve cardiac function and HF. Clinically this mechanism can only be exploited by a general activation of the proteinkinase A (PKA) which is associated with side effects and adverse clinical outcomes. A selective interference of the PLB-Serca2a interaction is desirable but will ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 16, 2021 Category: Physiology Authors: Maren E Arnold Wolfgang R Dostmann Jody Martin Michael J Previs Bradley Palmer Martin LeWinter Markus Meyer Source Type: research

Deficiency in Nebulin Repeats of Sarcomeric Nebulette is Detrimental for Cardiomyocyte Tolerance to Exercise and Biomechanical Stress
CONCLUSIONS: Upon stretch, NEBL deficiency causes disturbed sarcomere, Z-disks and desmin organization, and prevents NEBL redistribution to focal adhesions in cardiomyocytes, weakening cardiac tolerance to stress.PMID:33861145 | DOI:10.1152/ajpheart.00732.2020 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 16, 2021 Category: Physiology Authors: Ramona M Vejandla Buyan-Ochir Orgil Neely R Alberson Ning Li Undral Munkhsaikhan Zaza Khuchua Ruben Martherus Evren U Azeloglu Fuyi Xu Lu Lu Jeffrey A Towbin Enkhsaikhan Purevjav Source Type: research

Insulin Stimulation Reduces Aortic Waveform in Adults with Metabolic Syndrome
Am J Physiol Heart Circ Physiol. 2021 Apr 16. doi: 10.1152/ajpheart.00975.2020. Online ahead of print.ABSTRACTAdults with metabolic syndrome (MetS) have increased fasting arterial stiffness and altered central hemodynamics that contribute, partly, to increased cardiovascular disease (CVD) risk. Although insulin affects aortic wave reflections in healthy adults, the effects in individuals with MetS are unclear. We hypothesized that insulin stimulation would reduce measures of pressure waveforms and hemodynamics in people with MetS. Thirty-five adults with obesity (27F; 54.2 ± 6.0 yr; 37.1 ± 4.8 kg/m2) were sel...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 16, 2021 Category: Physiology Authors: Brielle L Dotson Emily M Heiston Stephanie L Miller Steven K Malin Source Type: research

A New Trick for an Old Dog? Myocardial-Specific Roles for Prostaglandins as Mediators of Ischemic Injury and Repair
Am J Physiol Heart Circ Physiol. 2021 Apr 16. doi: 10.1152/ajpheart.00872.2020. Online ahead of print.ABSTRACTThe small lipid-derived paracrine signalling molecules known as prostaglandins have been recognized for their ability to modulate many facets of cardiovascular physiology since their initial discovery more than 85 years ago. While the role of prostaglandins in the vasculature has gained significant attention across time, a handful of historical studies have also directly implicated the cardiomyocyte in both prostaglandin synthesis and release. Recently our understanding of how prostaglandin receptor modulation impa...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 16, 2021 Category: Physiology Authors: Matthew D Martens Amy S Amy Fernando Joseph W Gordon Source Type: research

Sildenafil Administration Improves Right Ventricular Function on 4D Flow MRI in Young Adults Born Premature
Am J Physiol Heart Circ Physiol. 2021 Apr 16. doi: 10.1152/ajpheart.00824.2020. Online ahead of print.ABSTRACTBACKGROUND: Extreme preterm birth conveys an elevated risk of heart failure by young adulthood. Smaller biventricular chamber size, diastolic dysfunction, and pulmonary hypertension may contribute to reduced ventricular-vascular coupling. However, how hemodynamic manipulations may affect right ventricular (RV) function and coupling remains unknown.METHODS: As a pilot study, 4D flow MRI was used to assess the effect of afterload reduction and heart rate reduction on cardiac hemodynamics and function. Young adults bo...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 16, 2021 Category: Physiology Authors: Philip A Corrado Gregory P Barton Christopher J Fran çois Oliver Wieben Kara N Goss Source Type: research

Mesenchymal stem cell-derived extracellular vesicles in the failing heart: past, present, and future
Am J Physiol Heart Circ Physiol. 2021 Apr 16. doi: 10.1152/ajpheart.00951.2020. Online ahead of print.ABSTRACTCardiovascular disease (CVD) is the leading cause of death globally. Current treatment options include lifestyle changes, medication, and surgical intervention. However, many patients are unsuitable candidates for surgeries due to comorbidities, diffuse coronary artery disease or advanced stages of heart failure. The search for new treatment options has recently transitioned from cell-based therapies to stem-cell derived extracellular vesicles (EVs). A number of challenges remain in the EV field, including the effe...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 16, 2021 Category: Physiology Authors: Catherine Karbasiafshar Frank W Sellke M Ruhul Abid Source Type: research

Serca2a-Phospholamban Interaction Monitored by an Interposed Circularly Permutated Green Fluorescent Protein
Am J Physiol Heart Circ Physiol. 2021 Apr 16. doi: 10.1152/ajpheart.00858.2020. Online ahead of print.ABSTRACTBACKGROUND: The interaction of phospholamban (PLB) and the sarcoplasmic reticulum Ca2+-ATPase (Serca2a) is a key regulator of cardiac contractility and a therapeutic target in heart failure (HF). PLB mediated increases in Serca2a activity improve cardiac function and HF. Clinically this mechanism can only be exploited by a general activation of the proteinkinase A (PKA) which is associated with side effects and adverse clinical outcomes. A selective interference of the PLB-Serca2a interaction is desirable but will ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 16, 2021 Category: Physiology Authors: Maren E Arnold Wolfgang R Dostmann Jody Martin Michael J Previs Bradley Palmer Martin LeWinter Markus Meyer Source Type: research

Deficiency in Nebulin Repeats of Sarcomeric Nebulette is Detrimental for Cardiomyocyte Tolerance to Exercise and Biomechanical Stress
CONCLUSIONS: Upon stretch, NEBL deficiency causes disturbed sarcomere, Z-disks and desmin organization, and prevents NEBL redistribution to focal adhesions in cardiomyocytes, weakening cardiac tolerance to stress.PMID:33861145 | DOI:10.1152/ajpheart.00732.2020 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 16, 2021 Category: Physiology Authors: Ramona M Vejandla Buyan-Ochir Orgil Neely R Alberson Ning Li Undral Munkhsaikhan Zaza Khuchua Ruben Martherus Evren U Azeloglu Fuyi Xu Lu Lu Jeffrey A Towbin Enkhsaikhan Purevjav Source Type: research

Insulin Stimulation Reduces Aortic Waveform in Adults with Metabolic Syndrome
Am J Physiol Heart Circ Physiol. 2021 Apr 16. doi: 10.1152/ajpheart.00975.2020. Online ahead of print.ABSTRACTAdults with metabolic syndrome (MetS) have increased fasting arterial stiffness and altered central hemodynamics that contribute, partly, to increased cardiovascular disease (CVD) risk. Although insulin affects aortic wave reflections in healthy adults, the effects in individuals with MetS are unclear. We hypothesized that insulin stimulation would reduce measures of pressure waveforms and hemodynamics in people with MetS. Thirty-five adults with obesity (27F; 54.2 ± 6.0 yr; 37.1 ± 4.8 kg/m2) were sel...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 16, 2021 Category: Physiology Authors: Brielle L Dotson Emily M Heiston Stephanie L Miller Steven K Malin Source Type: research

A New Trick for an Old Dog? Myocardial-Specific Roles for Prostaglandins as Mediators of Ischemic Injury and Repair
Am J Physiol Heart Circ Physiol. 2021 Apr 16. doi: 10.1152/ajpheart.00872.2020. Online ahead of print.ABSTRACTThe small lipid-derived paracrine signalling molecules known as prostaglandins have been recognized for their ability to modulate many facets of cardiovascular physiology since their initial discovery more than 85 years ago. While the role of prostaglandins in the vasculature has gained significant attention across time, a handful of historical studies have also directly implicated the cardiomyocyte in both prostaglandin synthesis and release. Recently our understanding of how prostaglandin receptor modulation impa...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 16, 2021 Category: Physiology Authors: Matthew D Martens Amy S Amy Fernando Joseph W Gordon Source Type: research

Sildenafil Administration Improves Right Ventricular Function on 4D Flow MRI in Young Adults Born Premature
Am J Physiol Heart Circ Physiol. 2021 Apr 16. doi: 10.1152/ajpheart.00824.2020. Online ahead of print.ABSTRACTBACKGROUND: Extreme preterm birth conveys an elevated risk of heart failure by young adulthood. Smaller biventricular chamber size, diastolic dysfunction, and pulmonary hypertension may contribute to reduced ventricular-vascular coupling. However, how hemodynamic manipulations may affect right ventricular (RV) function and coupling remains unknown.METHODS: As a pilot study, 4D flow MRI was used to assess the effect of afterload reduction and heart rate reduction on cardiac hemodynamics and function. Young adults bo...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 16, 2021 Category: Physiology Authors: Philip A Corrado Gregory P Barton Christopher J Fran çois Oliver Wieben Kara N Goss Source Type: research

Mesenchymal stem cell-derived extracellular vesicles in the failing heart: past, present, and future
Am J Physiol Heart Circ Physiol. 2021 Apr 16. doi: 10.1152/ajpheart.00951.2020. Online ahead of print.ABSTRACTCardiovascular disease (CVD) is the leading cause of death globally. Current treatment options include lifestyle changes, medication, and surgical intervention. However, many patients are unsuitable candidates for surgeries due to comorbidities, diffuse coronary artery disease or advanced stages of heart failure. The search for new treatment options has recently transitioned from cell-based therapies to stem-cell derived extracellular vesicles (EVs). A number of challenges remain in the EV field, including the effe...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 16, 2021 Category: Physiology Authors: Catherine Karbasiafshar Frank W Sellke M Ruhul Abid Source Type: research

Serca2a-Phospholamban Interaction Monitored by an Interposed Circularly Permutated Green Fluorescent Protein
Am J Physiol Heart Circ Physiol. 2021 Apr 16. doi: 10.1152/ajpheart.00858.2020. Online ahead of print.ABSTRACTBACKGROUND: The interaction of phospholamban (PLB) and the sarcoplasmic reticulum Ca2+-ATPase (Serca2a) is a key regulator of cardiac contractility and a therapeutic target in heart failure (HF). PLB mediated increases in Serca2a activity improve cardiac function and HF. Clinically this mechanism can only be exploited by a general activation of the proteinkinase A (PKA) which is associated with side effects and adverse clinical outcomes. A selective interference of the PLB-Serca2a interaction is desirable but will ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 16, 2021 Category: Physiology Authors: Maren E Arnold Wolfgang R Dostmann Jody Martin Michael J Previs Bradley Palmer Martin LeWinter Markus Meyer Source Type: research

Deficiency in Nebulin Repeats of Sarcomeric Nebulette is Detrimental for Cardiomyocyte Tolerance to Exercise and Biomechanical Stress
CONCLUSIONS: Upon stretch, NEBL deficiency causes disturbed sarcomere, Z-disks and desmin organization, and prevents NEBL redistribution to focal adhesions in cardiomyocytes, weakening cardiac tolerance to stress.PMID:33861145 | DOI:10.1152/ajpheart.00732.2020 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 16, 2021 Category: Physiology Authors: Ramona M Vejandla Buyan-Ochir Orgil Neely R Alberson Ning Li Undral Munkhsaikhan Zaza Khuchua Ruben Martherus Evren U Azeloglu Fuyi Xu Lu Lu Jeffrey A Towbin Enkhsaikhan Purevjav Source Type: research