The latest emerging drugs for the treatment of diabetic cardiomyopathy
Expert Opin Pharmacother. 2024 Apr 25. doi: 10.1080/14656566.2024.2347468. Online ahead of print.ABSTRACTINTRODUCTION: Diabetic cardiomyopathy (DCM) is a serious complication of diabetes mellitus involving multiple pathophysiologic mechanisms. In addition to hypoglycemic agents commonly used in diabetes, metabolism-related drugs, natural plant extracts, melatonin, exosomes, and rennin-angiotensin-aldosterone system are cardioprotective in DCM. However, there is a lack of systematic summarization of drugs for DCM.AREAS COVERED: In this review, the authors systematically summarize the most recent drugs used for the treatment...
Source: Expert Opinion on Pharmacotherapy - April 25, 2024 Category: Drugs & Pharmacology Authors: Minghao Li Lin Liu Chunyu Zhang Li Deng Yi Zhong Bin Liao Xiuying Li Ying Wan Jian Feng Source Type: research
Stereo-selective cardiac toxicity induced by metconazole via oxidative stress and the Wnt/ β-catenin signaling pathway in zebrafish embryos
We report stereoselectivity and severe cardiovascular defects in zebrafish, including pericardial oedema, decreased heart rate, increased sinus venous and bulbous arteries distances, intersegmental vessel defects, and altered cardiovascular development genes (hand2, gata4, nkx2.5, tbx5, vmhc, amhc, dll4, vegfaa, and vegfc). Further, MEZ significantly increased oxidative stress and apoptosis in zebrafish, primarily in the cardiac region. Isoquercetin, an antioxidant found in plants, partially mitigates MEZ-induced cardiac defects. Furthermore, MEZ upregulated the Wnt/β-catenin pathway genes (wnt3, β-catenin, axin2, and gs...
Source: Environmental Pollution - April 25, 2024 Category: Environmental Health Authors: Lulu Liu Fengzhong Wang Zhong Zhang Bei Fan Ying Luo Lin Li Yifan Zhang Zhihui Yan Zhiqiang Kong Fr édéric Francis Minmin Li Source Type: research
Implications of Cardiopulmonary Risk for the Management of COPD: A Narrative Review
Adv Ther. 2024 Apr 25. doi: 10.1007/s12325-024-02855-4. Online ahead of print.ABSTRACTChronic obstructive pulmonary disease (COPD) constitutes a major global health burden and is the third leading cause of death worldwide. A high proportion of patients with COPD have cardiovascular disease, but there is also evidence that COPD is a risk factor for adverse outcomes in cardiovascular disease. Patients with COPD frequently die of respiratory and cardiovascular causes, yet the identification and management of cardiopulmonary risk remain suboptimal owing to limited awareness and clinical intervention. Acute exacerbations punctu...
Source: Adv Data - April 25, 2024 Category: Epidemiology Authors: Dave Singh MeiLan K Han Nathaniel M Hawkins John R Hurst Janwillem W H Kocks Neil Skolnik Daiana Stolz Jad El Khoury Chris P Gale Source Type: research
Parents' Trigger Tool for Children with Medical Complexity - PAT-CMC: Development of a recognition tool for clinical deterioration at home
CONCLUSION: Priority indicators of clinical deterioration of CMC were identified and integrated into a validated trigger tool designed for parents or other lay caregivers at home, to recognize signs of acute severe illness and initiate healthcare interventions.IMPACT: The PAT-CMC was developed to guide families in recognizing signs of deterioration in CMC and has potential for initiating an early escalation of care. This tool may also be useful to support education provided by healthcare providers to families before hospital discharge.PATIENT OR PUBLIC CONTRIBUTION: Parents of CMC were directly involved in the selection of...
Source: Adv Data - April 25, 2024 Category: Epidemiology Authors: Catia Genna Kiara Ros Thekkan Caterina Geremia Michela Di Furia Corrado Cecchetti Emilia Rufini Michele Salata Daniela Perrotta Immacolata Dall'Oglio Emanuela Tiozzo Massimiliano Raponi Orsola Gawronski Source Type: research
Effects of residential socioeconomic polarization on high blood pressure among nursing home residents
CONCLUSIONS: We achieved our objective by demonstrating that concentrated deprivation is associated with worse cardiovascular outcomes even in a population with equal access to care. Measures that jointly consider economic and racial/ethnic polarization elucidate larger disparities than single domain measures.PMID:38663339 | DOI:10.1016/j.healthplace.2024.103243 (Source: Health and Place)
Source: Health and Place - April 25, 2024 Category: Environmental Health Authors: Hoda S Abdel Magid Samuel Jaros Yongmei Li Michael A Steinman Sei Lee Carmen Peralta Bocheng Jing Kathy Fung Christine K Liu Xiaojuan Liu Laura A Graham Michelle C Odden Source Type: research
Development and characterization of a first-in-class adjustable-dose gene therapy system
CONCLUSION: We report the development of a novel, low-cost therapeutic platform, designed to enable the replacement of subcutaneously administered protein treatments with a single-injection, adjustable-dose gene therapy.PMID:38663689 | DOI:10.1016/j.gene.2024.148500 (Source: Gene)
Source: Gene - April 25, 2024 Category: Genetics & Stem Cells Authors: Alex Goraltchouk Jared Lourie Judith M Hollander H Grace Rosen Atsutaro A Fujishiro Francesco Luppino Kai Zou Alexey Seregin Source Type: research
SGLT2-independent effects of canagliflozin on NHE3 and mitochondrial complex I activity inhibit proximal tubule fluid transport and albumin uptake
Am J Physiol Renal Physiol. 2024 Apr 25. doi: 10.1152/ajprenal.00005.2024. Online ahead of print.ABSTRACTBeyond glycemic control, SGLT2 inhibitors (SGLT2i) have protective effects on cardiorenal function. Renoprotection has been suggested to involve inhibition of NHE3 leading to reduced ATP-dependent tubular workload and mitochondrial oxygen consumption. NHE3 activity is also important for regulation of endosomal pH, but the effects of SGLT2i on endocytosis are unknown. We used a highly differentiated cell culture model of proximal tubule (PT) cells to determine the direct effects of SGLT2i on Na+-dependent fluid transport...
Source: Am J Physiol Renal P... - April 25, 2024 Category: Urology & Nephrology Authors: Wafaa N Albalawy Elynna B Youm Katherine E Shipman Keelan J Trull Catherine J Baty Kimberly R Long Youssef Rbaibi Xue-Ping Wang Olayemi G Fagunloye Katharine A White Michael J Jurczak Ossama B Kashlan Ora A Weisz Source Type: research
Reply: Asthma and cardiovascular disease: the strength of triangulation
Eur Respir J. 2024 Apr 25;63(4):2400554. doi: 10.1183/13993003.00554-2024. Print 2024 Apr.NO ABSTRACTPMID:38663973 | DOI:10.1183/13993003.00554-2024 (Source: Respiratory Care)
Source: Respiratory Care - April 25, 2024 Category: Respiratory Medicine Authors: Chloe I Bloom Source Type: research
Does engagement matter? The impact of patient and community engagement on implementation of cardiovascular health materials in primary care settings
CONCLUSIONS: In this study, patients and community members generated common and unique messages and materials for cardiovascular disease prevention relevant to their regional and community culture. Primary care practices preferred the materials created in their region. The greater uptake of locally created materials over non-local materials supports the use of patient engagement methods such as BCT to increase the implementation and delivery of guideline-based care. Yes, patient and community engagement matters.TRIAL REGISTRATION AND IRB: Trial registration was prospectively registered on July 31, 2015 at ClinicalTrials.go...
Source: Primary Care - April 25, 2024 Category: Primary Care Authors: Linda Zittleman John M Westfall Danelle Callen Alisha M Herrick Carolina Nkouaga Matthew Simpson L Miriam Dickinson Douglas Fernald Arthur Kaufman Aimee F English W Perry Dickinson Donald E Nease Source Type: research
A Bibliometric Analysis of Study of Associations of Certain Genotypes with the Cardiovascular Form of Diabetic Neuropathy
Biomed Res Int. 2024 Apr 15;2024:6761451. doi: 10.1155/2024/6761451. eCollection 2024.ABSTRACTThis bibliometric analysis explores the landscape of research on the associations between specific genotypes and the cardiovascular form of diabetic neuropathy. Diabetes mellitus (DM) is a major contributor to premature mortality, primarily due to increased susceptibility to cardiovascular diseases. The global prevalence of DM is rising, with projections indicating further increases. Diabetic neuropathy, a complication of DM, includes the cardiovascular subtype, posing challenges in diagnosis and management. Understanding the gene...
Source: Biomed Res - April 25, 2024 Category: Research Authors: Nazira B Bekenova Tamara A Vochshenkova Nurgul Ablakimova Aliya Zhylkybekova Nadiar M Mussin Rustam K Albayev Asset A Kaliyev Amin Tamadon Source Type: research
Impact of abdominal compression on heart and stomach motion for stereotactic arrhythmia radioablation
CONCLUSIONS: AC was not a consistent motion management method for STAR, nor does not uniformly affect the separation distance between LVCs and the stomach. If AC is employed in future STAR protocols, the motion of the target volume and its relative distance to the stomach should be compared on two 4DCTs: one while the patient is FB and one under AC.PMID:38661250 | DOI:10.1002/acm2.14346 (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - April 25, 2024 Category: Information Technology Authors: Daniel David Cecchi Nicolas Paul Ploquin Salman Faruqi Hali Morrison Source Type: research
Growth differentiation factor-15 serum concentrations reflect disease severity and anemia in patients with inflammatory bowel disease
CONCLUSION: For the first time, we demonstrated that serum concentrations of GDF-15 are elevated in patients with IBD in comparison to healthy controls, and the results imply that GDF-15 might be involved in IBD pathophysiology. Yet, it remains elusive whether GDF-15 could serve as a prognostic indicator in these patients.PMID:38659482 | PMC:PMC11036493 | DOI:10.3748/wjg.v30.i13.1899 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 25, 2024 Category: Gastroenterology Authors: Ante Tonkic Marko Kumric Ivna Akrapovic Olic Doris Rusic Piero Marin Zivkovic Daniela Supe Domic Zeljko Sundov Ivan Males Josko Bozic Source Type: research
Phospholipid Analyses of Rabbit Ocular Surface Tissues
This study (1) establishes PL profiles of the two ocular tissues of the integument that cover the surface of the eye, (2) compares and contrasts indices comprised of ratios and combinations of PL, and (3) describes pathway-specific metabolic interrelations among these tissues to serve as baselines for studies involving the distribution of tissue phospholipids.PMID:38663719 | DOI:10.1016/j.exer.2024.109911 (Source: Experimental Eye Research)
Source: Experimental Eye Research - April 25, 2024 Category: Opthalmology Authors: Jack V Greiner Thomas Glonek Source Type: research
Temporal trend in mortality due to congenital heart disease in China from 2008 to 2021
CONCLUSIONS: CHD mortality in China has dramatically decreased from 2008 to 2021. The slower decrease in CHD mortality in the central and western regions than in the eastern regions suggested that public health policymakers should pay more attention to health resources and health education for central and western regions.PMID:38663857 | DOI:10.1097/CM9.0000000000003057 (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - April 25, 2024 Category: General Medicine Authors: Youping Tian Xiaojing Hu Qing Gu Miao Yang Pin Jia Xiaojing Ma Xiaoling Ge Quming Zhao Fang Liu Ming Ye Weili Yan Guoying Huang Source Type: research
Two Symptom Clusters Identified in Patients with Acute Heart Failure
According to this study: Two distinct symptom clusters were identified in patients with acute heart failure: one with severe congestion and the other with mild congestion.Identification of these symptom clusters in the ED could help with symptom management, patient triage, diagnosis, and self-care at home.PMID:38661705 | DOI:10.1097/01.NAJ.0001016392.13580.5b (Source: The American Journal of Nursing)
Source: The American Journal of Nursing - April 25, 2024 Category: Nursing Authors: Karen Rosenberg Source Type: research
