Predicting Lipid-Lowering Medication Persistence after the First Cardiovascular Disease Hospitalization.
CONCLUSION:  The results suggest that development of a machine learning-based clinical decision support tool to focus improvements in secondary prevention of CVD is feasible. PMID: 32726811 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - July 29, 2020 Category: Information Technology Authors: Hu F, Warren J, Exeter DJ Tags: Methods Inf Med Source Type: research

Protective Effects of Ischemic Postconditioning on Livers in Rats with Limb Ischemia-Reperfusion via Glycogen Synthase Kinase 3 beta (GSK-3 β)/Fyn/Nuclear Receptor-Erythroid-2-Related Factor (Nrf2) Pathway.
CONCLUSIONS IPO protects against liver injury caused by I/R injury of the hindlimb, possibly via the GSK-3ß/Fyn/Nrf2 pathway. PMID: 32686659 [PubMed - in process] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - July 20, 2020 Category: Information Technology Authors: Niu Q, Sun W, Chen Q, Long Y, Cao W, Wen S, Li A, Dong F, Shi H Tags: Med Sci Monit Source Type: research

Tofacitinib in Treatment-Refractory Moderate to Severe Ulcerative Colitis: Real-World Experience from a Retrospective Multicenter Observational Study.
Abstract (1) Background: Tofacitinib is approved in Europe for the treatment of adults with moderately to severely active ulcerative colitis since 2018. Real-world efficacy and safety data are currently scarce. (2) Methods: We performed a retrospective multicenter study at three German tertiary outpatient clinics for inflammatory bowel diseases and included all patients who started tofacitinib therapy between August 2018 and March 2020. The primary endpoint was a combined endpoint of steroid-free clinical remission, steroid-free clinical response, or clinical response at week 8. Secondary endpoints were biochemica...
Source: Methods of Information in Medicine - July 10, 2020 Category: Information Technology Authors: Hoffmann P, Globig AM, Thomann AK, Grigorian M, Krisam J, Hasselblatt P, Reindl W, Gauss A Tags: J Clin Med Source Type: research

A Systematic Review of the Effectiveness of Telerehabilitation Interventions for Therapeutic Purposes in the Elderly.
CONCLUSION:  Telerehabilitation services can be regarded as an alternative to traditional rehabilitation approaches to reduce outpatient resource utilization and improve quality of life. However, more rigorous studies are suggested to investigate the effectiveness of telerehabilitation services for specific diseases or health conditions. PMID: 32629502 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - July 6, 2020 Category: Information Technology Authors: Velayati F, Ayatollahi H, Hemmat M Tags: Methods Inf Med Source Type: research

Mental health of postgraduate trainees in primary care: a cross-sectional study.
Abstract BACKGROUND: General Practitioners (GPs) are increasingly affected by stress-related complaints and burnout. Although many studies have addressed this issue, little is known about the stress burden and burnout rates of postgraduate trainees specialising in General Practice (GP). This cross-sectional study was performed to explore the prevalence and risk of depression, stress and burnout in a large cohort of GP trainees. METHODS: All GP trainees enrolled in the postgraduate training programme KWBW Verbundweiterbildungplus© in southwest Germany were invited to participate. A paper-based survey for ...
Source: Methods of Information in Medicine - June 27, 2020 Category: Information Technology Authors: Bugaj TJ, Krug K, Rentschler A, Nikendei C, Szecsenyi J, Schwill S Tags: BMC Fam Pract Source Type: research

Mortality and functional outcome after surgical evacuation of traumatic acute subdural hematomas in octa- and nonagenarians.
CONCLUSION: Outcome after surgical treatment of aSDH in octa- and nonagenarians is not detrimental per se. Predictors for a favorable outcome are a non-comatose state on admission (GCS > 8), ≤ 1 preexisting comorbidity and a lower aSDH volume in patients aged ≥ 80 years. In individual patients, surgical evacuation of aSDH might remain a treatment option even in high ages. PMID: 32594213 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - June 27, 2020 Category: Information Technology Authors: Younsi A, Fischer J, Habel C, Riemann L, Scherer M, Unterberg A, Zweckberger K Tags: Eur J Trauma Emerg Surg Source Type: research

Comparison of loss of response between anti-tumor necrosis factor alone and combined use with immunomodulators in patients with inflammatory bowel disease.
Conclusions: Anti-TNF and IMM combination therapy did not prove efficacious in preventing the development of LOR in IBD patients. Female sex was associated with the development of LOR to anti-TNF; further studies are required to confirm these results. PMID: 32580540 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - June 25, 2020 Category: Information Technology Authors: Hong SW, Park J, Yoon H, Yang HR, Shin CM, Park YS, Kim N, Lee DH, Kim JS Tags: Korean J Intern Med Source Type: research

Comparison of Two Information Sources for Cause-of-Death Follow-up in the Russian Federation: The Asbest Chrysotile Cohort Study.
CONCLUSIONS:  RL completeness and agreement of cause-of-death information obtained from ZAGS and from MIAC were both very high. This is reassuring for the quality of cancer mortality follow-up of the Asbest chrysotile cohort. For future epidemiological studies in the Russian Federation, ZAGS appears to be a reliable information source for mortality follow-up, if the automated RL is complemented with manual searches of cohort members. MIAC is a good resource for prospective studies. PMID: 32535878 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - June 14, 2020 Category: Information Technology Authors: Schüz J, Kovalevskiy E, Moissonnier M, Olsson A, Hashim D, Kromhout H, Kashanskiy S, Chernov O, Bukhtiyarov I, Ostroumova E Tags: Methods Inf Med Source Type: research

Applying FAIR Principles to Improve Data Searchability of Emergency Department Datasets: A Case Study for HCUP-SEDD.
CONCLUSION:  In this case study, the distribution of datasets from HCUP-SEDD was made more FAIR through the development of a search tool, EDCat. EDCat will be evaluated and developed further to include datasets from other sources. PMID: 32535879 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - June 14, 2020 Category: Information Technology Authors: Bhatia K, Tanch J, Chen ES, Sarkar IN Tags: Methods Inf Med Source Type: research

Design of a Low-Cost, Wearable Device for Kinematic Analysis in Physical Therapy Settings.
CONCLUSION:  Device-guided home physical rehabilitation can allow for individualized treatment protocols and improve exercise self-efficacy through kinematic analysis. Future studies should implement clinical testing to evaluate the impact a wearable device can have on rehabilitation outcomes. PMID: 32535880 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - June 14, 2020 Category: Information Technology Authors: Hua A, Johnson N, Quinton J, Chaudhary P, Buchner D, Hernandez ME Tags: Methods Inf Med Source Type: research

Low-resolution pressure reactivity index and its derived optimal cerebral perfusion pressure in adult traumatic brain injury: a CENTER-TBI study.
CONCLUSIONS: LPRx and its derived "optimal CPP" which are based on low-resolution data were significantly associated with outcome after TBI. However, they did not reach the discriminative ability of the high-resolution PRx and its derived "optimal CPP." Nevertheless, LPRx might still be an interesting tool to assess cerebrovascular reactivity in centers without high-resolution signal monitoring. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT02210221. First submitted July 29, 2014. First posted August 6, 2014. PMID: 32456684 [PubMed - in process] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - May 26, 2020 Category: Information Technology Authors: Riemann L, Beqiri E, Smielewski P, Czosnyka M, Stocchetti N, Sakowitz O, Zweckberger K, Unterberg A, Younsi A, CENTER-TBI High Resolution ICU (HR ICU) Sub-Study Participants and Investigators Tags: Crit Care Source Type: research

TNF- α - 308 G/A and IFN-γ + 874 A/T gene polymorphisms in Saudi patients with cutaneous leishmaniasis.
This study was undertaken to test the association of TNF-α - 308 and IFN-γ + 874 gene polymorphisms with the susceptibility of Leishmania (L) species among CL patients in central region of Saudi Arabia. METHODS: This is a case-control study involved 169 Saudi subjects with different L. species and 199 healthy controls from central region of Saudi Arabia. All subjects were characterized by TNF-α - 308 G/A and IFN-γ + 874 A/T gene polymorphisms using PCR. RESULTS: Evaluation of genotyping and allelic frequency of TNF-α&thin...
Source: Methods of Information in Medicine - May 13, 2020 Category: Information Technology Authors: Ahmed AA, Rasheed Z, Salem T, Al-Dhubaibi MS, Al Robaee AA, Alzolibani AA Tags: BMC Med Genet Source Type: research

Cryoballoon pulmonary vein isolation-mediated rise of sinus rate in patients with paroxysmal atrial fibrillation.
Abstract BACKGROUND: Modulation of the cardiac autonomic nervous system by pulmonary vein isolation (PVI) influences the sinoatrial nodal rate. Little is known about the causes, maintenance and prognostic value of this phenomenon. We set out to explore the effects of cryoballoon PVI (cryo-PVI) on sinus rate and its significance for clinical outcome. METHODS AND RESULTS: We evaluated 110 patients with paroxysmal atrial fibrillation (AF), who underwent PVI using a second-generation 28 mm cryoballoon by pre-, peri- and postprocedural heart rate acquisition and analysis of clinical outcome. Ninety-one patien...
Source: Methods of Information in Medicine - May 13, 2020 Category: Information Technology Authors: Wagner L, Darche FF, Thomas D, Lugenbiel P, Xynogalos P, Seide S, Scholz EP, Katus HA, Schweizer PA Tags: Clin Res Cardiol Source Type: research

A Method to Extract Feature Variables Contributed in Nonlinear Machine Learning Prediction.
CONCLUSION:  The results showed that models can be evaluated from different viewpoints by using different factor extraction techniques. In the future, we hope to use this technique to verify the characteristics of features extracted by factor extraction technique, and to perform clinical studies using the genes, we extracted in this experiment. PMID: 32380557 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - May 7, 2020 Category: Information Technology Authors: Suzuki M, Shibahara T, Muragaki Y Tags: Methods Inf Med Source Type: research

The effect of diabetes on vitreous levels of adiponectin and inflammatory cytokines in experimental rat model.
m Z Abstract BACKGROUND: Diabetic retinopathy is one of the most common eye diseases faced by diabetic patients. It is a slow-progressing complication that results from damage to the blood vessels of the retina. OBJECTIVES: To investigate the role of adiponectin and inflammatory cytokines in the vitreous of diabetic rats. MATERIAL AND METHODS: The study was conducted in 3-4-month-old male albino Wistar rats (180-240 g). The animals were divided into 2 groups (n = 40 in each group): the diabetes group and the control group. A single dose of streptozotocin (STZ) (45 mg/kg) in citrate buffer (0.1 M; pH 4.5)...
Source: Methods of Information in Medicine - April 28, 2020 Category: Information Technology Authors: Özay Y, Ozek D, Yıldırım F, Yıldırım Z Tags: Adv Clin Exp Med Source Type: research

Role of NF- κB transcriptional factor activation during chronic fluoride intoxication in development of oxidative-nitrosative stress in rat's gastric mucosa.
CONCLUSIONS: Activation of NF-κB during chronic fluoride intoxication leads to the development of hyperproduction of NO and development of oxidative-nitrosative stress. PMID: 32344277 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - April 19, 2020 Category: Information Technology Authors: Akimov OY, Kostenko VO Tags: J Trace Elem Med Biol Source Type: research

Protective effect of total flavonoids from Ixeris Sonchifolia on herpes simplex virus keratitis in mice.
CONCLUSIONS: ISH could increase the anti-virus ability, promote the healing of corneal inflammation and alleviate the pathological damage of cornea, which suggested that ISH has a potential and valuable therapeutic effect on the HSK. PMID: 32295580 [PubMed - in process] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - April 15, 2020 Category: Information Technology Authors: Wang YQ, Cai L, Zhang N, Zhang J, Wang HH, Zhu W Tags: BMC Complement Med Ther Source Type: research

How to ensure basic competencies in end of life care - a mixed methods study with post-graduate trainees in primary care in Germany.
Abstract BACKGROUND: Providing end of life care (EoLC) is an important aspect of primary care, which reduces the risk of hospital admission for most patients. However, general practitioners (GPs) seem to have low confidence in their ability to provide EoLC. Little is known about an adequate volume and kind of training in EoLC among GP trainees. METHODS: We performed a before-after comparison in all post-graduate GP trainees who were registered in the vocational training program (KWBW VerbundweiterbildungPLUS). They were offered participation within a two-day seminar focussing on palliative care in 2017. Those...
Source: Methods of Information in Medicine - March 24, 2020 Category: Information Technology Authors: Schwill S, Reith D, Walter T, Engeser P, Wensing M, Flum E, Szecsenyi J, Krug K Tags: BMC Palliat Care Source Type: research

Notoginsenoside R1 Suppresses Inflammatory Signaling and Rescues Renal Ischemia-Reperfusion Injury in Experimental Rats.
CONCLUSIONS NR suppressed I/R-induced inflammatory cytokines production by suppressing oxidative stress and kidney markers, suggesting that NR is a promising drug candidate for prevention, progression, and treatment of renal dysfunction. PMID: 32198879 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - March 21, 2020 Category: Information Technology Authors: Fan C, Chen Q, Ren J, Yang X, Ru J, Zhang H, Yang X Tags: Med Sci Monit Source Type: research

Disease awareness or subtle product placement? Orphan diseases featured in the television series "House, M.D." - a cross-sectional analysis.
This study aimed to describe the presentation of orphan diseases in the television series "House, M.D.", to test in an exploratory fashion the hypothesis that treatable orphan conditions are overrepresented in "House, M.D." and to discuss whether such marketing practices may or may not be ethical. METHODS: A list of all medical cases depicted in the television series "House, M.D." was obtained and classified as orphan or non-orphan according to the Orphanet database. The ratios of orphan diseases among all diseases, such with an orphan drug designation and such with an orphan drug approva...
Source: Methods of Information in Medicine - March 14, 2020 Category: Information Technology Authors: Mechler K, Rausch J, Mountford WK, Ries M Tags: BMC Med Ethics Source Type: research

Modeling Care Team Structures in the Neonatal Intensive Care Unit through Network Analysis of EHR Audit Logs.
CONCLUSION:  Network analysis can be applied to EHR log data to model acuity-based NICU teams capturing interactions between providers within the predesigned core team as well as those outside of the core team. In the NICU, dissemination of information may be linked to reduced PSLOS. EHR log data provide an efficient, accessible, and research-friendly way to study provider interaction networks. Findings should guide improvements in the EHR system design to facilitate effective interactions between providers. PMID: 32170716 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - March 13, 2020 Category: Information Technology Authors: Chen Y, Lehmann CU, Hatch LD, Schremp E, Malin BA, France DJ Tags: Methods Inf Med Source Type: research

Effective Factors in Adoption of Mobile Health Applications between Medical Sciences Students Using the UTAUT Model.
CONCLUSIONS:  The present study provides valuable information on mobile health acceptance factors for widespread use of this device among students of universities of medical sciences as a base infrastructure for a variety of information about health services and learning. Review and comparison of results with other studies showed that mHealth acceptance factors were different from other end users (elderly, patients, and health professionals). PMID: 32170717 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - March 13, 2020 Category: Information Technology Authors: Garavand A, Samadbeik M, Nadri H, Rahimi B, Asadi H Tags: Methods Inf Med Source Type: research

Identification and Validation of Requirements for a Registry System of Children's Developmental Motor Disorders in Iran.
Abstract BACKGROUND:  Despite recent advances in the field of medical sciences, children's developmental motor disorders (DMDs) are considered as one of the challenges in this area. Establishment of electronic systems for recording and monitoring children's DMDs can play an effective role in identifying patients and reducing the costs and consequences of the disease management. The aim of this study was to identify and validate the requirements for a registry system of children's DMDs in Iran. METHODS:  The present descriptive-analytical study was performed in three main stages. In the first step, t...
Source: Methods of Information in Medicine - March 13, 2020 Category: Information Technology Authors: Gozali E, Safdari R, Ghazisaeedi M, Rahimi B, Eslamlou HF, Mehraeen E Tags: Methods Inf Med Source Type: research

Evaluating Manual Mappings of Russian Proprietary Formats and Terminologies to FHIR.
CONCLUSION:  Mapping medical formats is a challenge. The obtained overlaps are promising in comparison with the investigated results. The study showed that standardization of data exchange between proprietary formats and FHIR is possible in Russia, and national terminologies can be used in FHIR-based information systems. PMID: 32170719 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - March 13, 2020 Category: Information Technology Authors: Lenivtceva ID, Kopanitsa G Tags: Methods Inf Med Source Type: research

Applicability of scoring systems predicting outcome of transarterial chemoembolization for hepatocellular carcinoma.
Abstract PURPOSE: Several scoring systems have been proposed to predict the outcome of transarterial chemoembolization (TACE) in patients with hepatocellular carcinoma (HCC). However, the application of these scores to a bridging to transplant setting is poorly validated. Evaluation of the applicability of prognostic scores for patients undergoing TACE in palliative intention vs. bridging therapy to liver transplantation (LT) is necessary. METHODS: Between 2008 and 2017, 148 patients with HCC received 492 completed TACE procedures (158 for bridging to transplant; 334 TACE procedures in palliative treatment in...
Source: Methods of Information in Medicine - February 27, 2020 Category: Information Technology Authors: Vogeler M, Mohr I, Pfeiffenberger J, Sprengel SD, Klauss M, Teufel A, Chang DH, Springfeld C, Longerich T, Merle U, Mehrabi A, Weiss KH, Mieth M Tags: J Cancer Res Clin Oncol Source Type: research

Separation of HCM and LQT Cardiac Diseases with Machine Learning of Ca2+ Transient Profiles.
CONCLUSION:  The results indicate that the methods applied would be efficient for the identification of these genetic cardiac diseases. PMID: 32079026 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - February 20, 2020 Category: Information Technology Authors: Joutsijoki H, Penttinen K, Juhola M, Aalto-Setälä K Tags: Methods Inf Med Source Type: research

Information Extraction from Echocardiography Reports for a Clinical Follow-up Study-Comparison of Extracted Variables Intended for General Use in a Data Warehouse with Those Intended Specifically for the Study.
CONCLUSION:  Data from information extractions can be used for large clinical studies. However, preexisting information extraction processes should be treated with caution, as the time and effort spent defining each variable in the information extraction process may not be clear. PMID: 32000268 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - January 30, 2020 Category: Information Technology Authors: Kaspar M, Morbach C, Fette G, Ertl M, Seidlmayer LK, Krebs J, Dietrich G, Liman L, Puppe F, Störk S Tags: Methods Inf Med Source Type: research

In Vitro Characterization of a Novel Type of Radiopaque Doxorubicin-Loaded Microsphere.
CONCLUSION: V-100 is a promising novel type of radiopaque doxorubicin-loaded microsphere. Compared with the controls, V-100 shows good inherent radiopacity without adverse imaging artifacts and with comparable doxorubicin loading efficacy. Further advantages of V-100 include narrow-sized distribution and excellent suspension, rheology, and stability features. PMID: 31965224 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - January 21, 2020 Category: Information Technology Authors: Pan F, Schneider D, Ryschich E, Qian B, Vollherbst DF, Möhlenbruch MA, Jugold M, Eichwald V, Stenzel P, Pereira PL, Richter GM, Kauczor HU, Sommer CM, Do TD Tags: Cardiovasc Intervent Radiol Source Type: research

Interdisciplinary approach allows minimally invasive, nerve-sparing removal of retroperitoneal peripheral nerve sheath tumors.
CONCLUSIONS: Interdisciplinary, nerve-sparing removal of retroperitoneal PNST is well suited to improve preoperative symptoms and maintain neurological function, while achieving an oncological outcome and a surgical morbidity similar to previously reported results for radical retroperitoneal PNST resection. Radical re-resection was feasible in a patient with post hoc MPNST diagnosis. PMID: 31925504 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - January 11, 2020 Category: Information Technology Authors: Hajiabadi MM, Campos B, Sedlaczek O, Khajeh E, Nikdad M, von Deimling A, Mehrabi A, Unterberg A, Ahmadi R Tags: Langenbecks Arch Surg Source Type: research

Changes in the etiology of viral lower respiratory tract infections in hospitalized children in Wenzhou, China: 2008-2017.
This study investigated the seasonality and secular trends in the etiology of viral lower respiratory tract infections (LRTIs) among hospitalized children in Wenzhou, southeastern China. METHODS: A retrospective review was conducted concerning viral LRTIs in children hospitalized at a university hospital between January 1, 2008 and December 31, 2017. Direct immunofluorescence was used to detect respiratory syncytial virus (RSV), adenovirus (AdV), influenza A virus (Inf A), influenza B virus (Inf B), and human parainfluenza virus types 1-3 (hPIV1-3). RESULTS: Of 89,898 children tested, at least one viral respirato...
Source: Methods of Information in Medicine - December 30, 2019 Category: Information Technology Authors: Wen S, Yu M, Zheng G, Lv F, Chen X, Lin L, Li C, Zhang H Tags: J Med Virol Source Type: research

One Step Away from Technology but One Step Towards Domain Experts-MDRBridge: A Template-Based ISO 11179-Compliant Metadata Processing Pipeline.
CONCLUSION:  A high degree of acceptance was achieved by adapting the working methods of clinical domain experts. The designed process is capable of transforming all relevant data elements according to the ISO 11179-3 format. MDRSheet is used as an intermediate format to present the information at a glance and to allow editing or supplementing by domain experts. PMID: 31853911 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - December 18, 2019 Category: Information Technology Authors: Kock-Schoppenhauer AK, Kroll B, Lambarki M, Ulrich H, Stahl-Toyota S, Habermann JK, Duhm-Harbeck P, Ingenerf J, Lablans M Tags: Methods Inf Med Source Type: research

Tumor necrosis factor alpha mediates orofacial discomfort in an occlusal dental interference model in rats: the role of trigeminal ganglion inflammation.
In this study, we investigated the its role in orofacial discomfort in rats subjected to occlusal dental interference (ODI). METHODS: Female Wistar rats (180-200 g) were divided in three groups (n=30/group): Sham group, without ODI, and two experimental groups with ODI pretreated with 0.1 ml/kg saline (ODI+SAL) or 5 mg/kg infliximab (ODI+INF) and treated every three days. The animals were euthanized after 1, 3 and 7 days. The number of bites and scratches and grimace scale scores were determined daily, and the bilateral trigeminal ganglion was histomorphometrically (neuronal body area) analyzed and submitted for immun...
Source: Methods of Information in Medicine - December 12, 2019 Category: Information Technology Authors: de Barros Silva PG, de Lima Martins JO, de Lima Praxedes Neto RA, Mota Lemos JV, Machado LC, Matos Carlos ACA, Alves APNN, Lima RA Tags: J Oral Pathol Med Source Type: research

A Statistical Approach for the Learning Curve of Physicians in Utilization of Electronic Order Sets.
CONCLUSION:  Based on our finding, we reject our initial hypothesis. PMID: 31822033 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - December 10, 2019 Category: Information Technology Authors: Lee J, Hulse NC Tags: Methods Inf Med Source Type: research

DNA methylation-based profiling of uterine neoplasms: a novel tool to improve gynecologic cancer diagnostics.
CONCLUSION: Herein, we describe distinct DNA methylation signatures in uterine neoplasms and show that array-based DNA methylation analysis holds promise as an ancillary tool to further characterize uterine neoplasms, especially in cases which are diagnostically challenging by conventional techniques. PMID: 31768620 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - November 25, 2019 Category: Information Technology Authors: Kommoss FKF, Stichel D, Schrimpf D, Kriegsmann M, Tessier-Cloutier B, Talhouk A, McAlpine JN, Chang KTE, Sturm D, Pfister SM, Romero-Pérez L, Kirchner T, Grünewald TGP, Buslei R, Sinn HP, Mechtersheimer G, Schirmacher P, Schmidt D, Lehr HA, Sahm F, Hunt Tags: J Cancer Res Clin Oncol Source Type: research

Overrating Classifier Performance in ROC Analysis in the Absence of a Test Set: Evidence from Simulation and Italian CARATkids Validation.
CONCLUSIONS:  Splitting into training and test set avoids overrating the test performance in ROC analysis. Validated through this method, the Italian CARATkids is valid for assessing disease control in children with asthma and rhinitis. PMID: 31746447 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - November 19, 2019 Category: Information Technology Authors: Cilluffo G, Fasola S, Ferrante G, Montalbano L, Baiardini I, Indinnimeo L, Viegi G, Fonseca JA, La Grutta S Tags: Methods Inf Med Source Type: research

Serum potential biomarkers according to sputum inflammatory cell profiles in adult asthmatics.
Conclusions: The serum periostin and EDN levels may be used as predictors to discriminate the eosinophilic asthma group from patients having eosinophilic or mixed granulocytic asthma, and the serum folliculin level is significantly elevated in patients with paucigranulocytic asthma compared to those with different inflammatory cell profile. PMID: 31722514 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - November 15, 2019 Category: Information Technology Authors: Hur GY, Ye YM, Yang E, Park HS Tags: Korean J Intern Med Source Type: research

Methamphetamine Induces Intestinal Inflammatory Injury via Nod-Like Receptor 3 Protein (NLRP3) Inflammasome Overexpression In Vitro and In Vivo.
CONCLUSIONS METH, in addition to being a confirmed neurotoxic drug, can also cause severe intestinal inflammatory injury via NLRP3 inflammasome overexpression. NF-kappaB may be an activator of the NLRP3 inflammasome in METH intestinal inflammatory injury. PMID: 31712546 [PubMed - in process] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - November 12, 2019 Category: Information Technology Authors: Zhao J, Shen S, Dai Y, Chen F, Wang K Tags: Med Sci Monit Source Type: research

Inhibition of miRNA-222-3p Relieves Staphylococcal Enterotoxin B-Induced Liver Inflammatory Injury by Upregulating Suppressors of Cytokine Signaling 1.
CONCLUSION: Inhibition of miR-222-3p relieves SEB-induced liver inflammatory injury by upregulating SOCS1, thereby providing the first evidence of miR-222-3p in SEB-induced liver injury. PMID: 31637892 [PubMed - in process] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - October 23, 2019 Category: Information Technology Authors: Zhang P, Yu J, Gui Y, Sun C, Han W Tags: Yonsei Med J Source Type: research

Synthesis and structure activity relationship of 1, 3-benzo-thiazine-2-thiones as selective HDAC8 inhibitors.
lmes FJ Abstract Human histone deacetylase 8 (HDAC8) is a highly promising target for neuroblastoma and other types of cancer. Several HDAC inhibitors are approved for the treatment of special cancer subtypes or are evaluated in clinical trials. By far the most drugs or drug candidates contain a hydroxamate group that chelates the catalytic zinc ion within HDACs. Most hydroxamate inhibitors are more or less unselective, although there are considerable exceptions demonstrating the general feasibility to develop at least HDAC isoenzyme selective inhibitors. In addition, hydroxamates have recently come under discussi...
Source: Methods of Information in Medicine - October 7, 2019 Category: Information Technology Authors: Wolff B, Jänsch N, Sugiarto WO, Frühschulz S, Lang M, Altintas R, Oehme I, Meyer-Almes FJ Tags: Eur J Med Chem Source Type: research

A Clinical Feasibility Study To Image Angiogenesis in Patients With Arteriovenous Malformations Using 68Ga-RGD PET/CT.
Conclusion: This feasibility study showed increased radiotracer uptake in AVM with angiogenic activity compared to surrounding tissue without angiogenic activity, suggesting that 68Ga-RGD PET/CT imaging can be used as a tool to quantitatively determine angiogenesis in AVM. Further studies will be conducted to explore the potential of 68Ga-RGD PET/CT imaging for guiding current treatment decisions and for assessment of response to anti-angiogenic treatment. PMID: 31519800 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - September 13, 2019 Category: Information Technology Authors: Lobeek D, Bouwman FCM, Aarntzen EHJG, Molkenboer-Kuenen JDM, Flucke UE, Nguyen HL, Vikkula M, Boon LM, Klein W, Laverman P, Oyen WJG, Boerman OC, Terry SYA, SchultzeKool LJ, Rijpkema M Tags: J Nucl Med Source Type: research

Impact of inferior vena cava ligation on mortality in trauma patients.
Abstract OBJECTIVE: Inferior vena cava (IVC) injuries are potentially lethal and require prompt intervention. Repair of complex IVC injuries may require the use of a prosthetic graft or a complicated panel or spiral vein graft reconstruction to avoid the need for ligation. Collateral venous drainage may be sufficient to allow acceptable results from IVC ligation; however, previous studies have suffered from low numbers and have differing results. The aims of this study were to assess the outcomes of isolated IVC injuries overall and to compare IVC ligation with repair. METHODS: Patients in the National Trauma...
Source: Methods of Information in Medicine - September 9, 2019 Category: Information Technology Authors: Byerly S, Cheng V, Plotkin A, Matsushima K, Inaba K, Magee GA Tags: J Vasc Surg Venous Lymphat Disord Source Type: research

The Differing Effect of Gender and Clinical Specialty on Physicians' Intention to Use Electronic Medical Record.
CONCLUSIONS:  The proposed research framework contributes to the conclusive explanation for interpreting physicians' intention to use EMR. Physicians generally have a higher level of computer literacy. Therefore, the factor of PEOU could not be critical regarding adopting new health information technology (HIT). This study also brings perspectives from the gender, and clinical differences have primarily been missing in the literature of the physicians' intention to use HIT. In doing so, it infers how gender, and clinical specialty, may complement (and in some instances, reinforce) the influence of technological and at...
Source: Methods of Information in Medicine - September 9, 2019 Category: Information Technology Authors: Hwang HG, Dutta B, Chang HC Tags: Methods Inf Med Source Type: research

Clinical Decision-Support Systems for Detection of Systemic Inflammatory Response Syndrome, Sepsis, and Septic Shock in Critically Ill Patients: A Systematic Review.
CONCLUSIONS:  The review demonstrated the high variety of research in this context successfully. A clear trend is observable toward the use of data-driven algorithms, and a lack of research could be identified in covering the pediatric population as well as acknowledging SIRS as an independent and threatening condition. The quality as well as the significance of the presented evaluations for assessing the performances of the algorithms in clinical routine settings are often not meeting the current standard of scientific work. Our future interest will be concentrated on these realistic settings by implementing and eval...
Source: Methods of Information in Medicine - September 9, 2019 Category: Information Technology Authors: Wulff A, Montag S, Marschollek M, Jack T Tags: Methods Inf Med Source Type: research

Laparoscopic Suprapancreatic Lymph Node Dissection Using a Systematic Mesogastric Excision Concept for Gastric Cancer.
CONCLUSIONS: We believe that this laparoscopic suprapancreatic lymphadenectomy using SME takes advantage of the surgical anatomy and achieves en bloc removal of the primary tumor and gastric mesentery. This series is a proof of concept that this procedure can be performed in a timely manner and is feasible. PMID: 31407184 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - August 12, 2019 Category: Information Technology Authors: Kumamoto T, Kurahashi Y, Niwa H, Nakanishi Y, Ozawa R, Okumura K, Ishida Y, Shinohara H Tags: Ann Surg Oncol Source Type: research

Hyper-G: An Artificial Intelligence Tool for Optimal Decision-Making and Management of Blood Glucose Levels in Surgery Patients.
CONCLUSIONS:  Machine learning models are able to accurately predict peak glucose levels during surgery. Implementation of such a model as a web-based application can facilitate optimal decision-making and advance planning of glucose management strategies. PMID: 31398727 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - August 9, 2019 Category: Information Technology Authors: Nair AA, Velagapudi M, Behara L, Venigandla R, Fong CT, Horibe M, Nair BG Tags: Methods Inf Med Source Type: research

Comparison of PSMA-ligand PET/CT and multiparametric MRI for the detection of recurrent prostate cancer in the pelvis.
CONCLUSIONS: PSMA-PET/CT detected more pelvic lesions characteristic for rPC when compared to MRI. In order to detect rPC, a potential future scenario could be conducting first a PSMA-PET/CT. Combining the advantages of both modalities in hybrid PET/MRI scanners would be an ideal future scenario. PMID: 31350604 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - July 27, 2019 Category: Information Technology Authors: Afshar-Oromieh A, Vollnberg B, Alberts I, Bähler A, Sachpekidis C, Dijkstra L, Haupt F, Boxler S, Gross T, Holland-Letz T, Thalmann G, Heverhagen J, Rominger A, Härmä K, Maurer MH Tags: Eur J Nucl Med Mol Imaging Source Type: research

Directions for surgical capacity developments in Nepal: a population-based assessment.
CONCLUSIONS: This study defined four focus areas that showed the largest unmet needs that resulted in a perceived disability. For those areas, affordability, availability, and acceptability of surgical need to be addressed through technical developments, capacity building, and raising awareness. This article is protected by copyright. All rights reserved. PMID: 31328362 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - July 22, 2019 Category: Information Technology Authors: Knulst AJ, Gupta S, Groen RS, Maharjan D, Kapendra AS, Dankelman J, Kushner AL Tags: Trop Med Int Health Source Type: research

The effect of a spectral filter on visual quality in patients with an extended-depth-of-focus intraocular lens.
CONCLUSIONS: Symfony's spectral dependence was observed to affect visual acuity and contrast sensitivity. Although the red filter did not improve distance vision, it caused visual deterioration at near. One might take this effect into account when optimizing the reading performance of patients with diffractive IOLs. PMID: 31323200 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - July 16, 2019 Category: Information Technology Authors: Łabuz G, Auffarth GU, Özen A, van den Berg TJ, Yildirim TM, Son HS, Khoramnia R Tags: Am J Ophthalmol Source Type: research

Pacemaker cell characteristics of differentiated and HCN4-transduced human mesenchymal stem cells.
izer PA Abstract AIMS: Cell-based biological pacemakers aim to overcome limitations and side effects of electronic pacemaker devices. We here developed and tested different approaches to achieve nodal-type differentiation using human adipose- and bone marrow-derived mesenchymal stem cells (haMSC, hbMSC). MAIN METHODS: haMSC and hbMSC were differentiated using customized protocols. Quantitative RT-PCR was applied for transcriptional pacemaker-gene profiling. Protein membrane expression was analyzed by immunocytochemistry. Pacemaker current (If) was studied in haMSC with and without lentiviral HCN4-transduction...
Source: Methods of Information in Medicine - July 7, 2019 Category: Information Technology Authors: Darche FF, Rivinius R, Köllensperger E, Leimer U, Germann G, Seckinger A, Hose D, Schröter J, Bruehl C, Draguhn A, Gabriel R, Schmidt M, Koenen M, Thomas D, Katus HA, Schweizer PA Tags: Life Sci Source Type: research

Effect of Dexmedetomidine-Mediated Insulin-Like Growth Factor 2 (IGF2) Signal Pathway on Immune Function and Invasion and Migration of Cancer Cells in Rats with Ovarian Cancer.
Abstract BACKGROUND The aim of this study was to explore the effect of dexmedetomidine (DEX)-mediated insulin-like growth factor 2 (IGF2) signal pathway on immune function and cancer cell invasion and migration in rats with ovarian cancer. MATERIAL AND METHODS Forty rats with ovarian cancer were divided into 4 groups: model group, and low dose (0.2 μg/kg/hour DEX), medium dose (1.0 μg/kg/hour DEX), and high dose (5.0 μg/kg/hour DEX) DEX groups. In addition, 10 Fischer344 rats were selected as a normal group. Human NUTU-19 poorly differentiated epithelial ovarian cancer cell line cells were divided into 4 ...
Source: Methods of Information in Medicine - June 23, 2019 Category: Information Technology Authors: Tian H, Hou L, Xiong Y, Cheng Q, Huang J Tags: Med Sci Monit Source Type: research