Inhibition of miRNA-222-3p Relieves Staphylococcal Enterotoxin B-Induced Liver Inflammatory Injury by Upregulating Suppressors of Cytokine Signaling 1.
CONCLUSION: Inhibition of miR-222-3p relieves SEB-induced liver inflammatory injury by upregulating SOCS1, thereby providing the first evidence of miR-222-3p in SEB-induced liver injury. PMID: 31637892 [PubMed - in process] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - October 23, 2019 Category: Information Technology Authors: Zhang P, Yu J, Gui Y, Sun C, Han W Tags: Yonsei Med J Source Type: research

Synthesis and structure activity relationship of 1, 3-benzo-thiazine-2-thiones as selective HDAC8 inhibitors.
lmes FJ Abstract Human histone deacetylase 8 (HDAC8) is a highly promising target for neuroblastoma and other types of cancer. Several HDAC inhibitors are approved for the treatment of special cancer subtypes or are evaluated in clinical trials. By far the most drugs or drug candidates contain a hydroxamate group that chelates the catalytic zinc ion within HDACs. Most hydroxamate inhibitors are more or less unselective, although there are considerable exceptions demonstrating the general feasibility to develop at least HDAC isoenzyme selective inhibitors. In addition, hydroxamates have recently come under discussi...
Source: Methods of Information in Medicine - October 7, 2019 Category: Information Technology Authors: Wolff B, Jänsch N, Sugiarto WO, Frühschulz S, Lang M, Altintas R, Oehme I, Meyer-Almes FJ Tags: Eur J Med Chem Source Type: research

A Clinical Feasibility Study To Image Angiogenesis in Patients With Arteriovenous Malformations Using 68Ga-RGD PET/CT.
Conclusion: This feasibility study showed increased radiotracer uptake in AVM with angiogenic activity compared to surrounding tissue without angiogenic activity, suggesting that 68Ga-RGD PET/CT imaging can be used as a tool to quantitatively determine angiogenesis in AVM. Further studies will be conducted to explore the potential of 68Ga-RGD PET/CT imaging for guiding current treatment decisions and for assessment of response to anti-angiogenic treatment. PMID: 31519800 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - September 13, 2019 Category: Information Technology Authors: Lobeek D, Bouwman FCM, Aarntzen EHJG, Molkenboer-Kuenen JDM, Flucke UE, Nguyen HL, Vikkula M, Boon LM, Klein W, Laverman P, Oyen WJG, Boerman OC, Terry SYA, SchultzeKool LJ, Rijpkema M Tags: J Nucl Med Source Type: research

Impact of inferior vena cava ligation on mortality in trauma patients.
Abstract OBJECTIVE: Inferior vena cava (IVC) injuries are potentially lethal and require prompt intervention. Repair of complex IVC injuries may require the use of a prosthetic graft or a complicated panel or spiral vein graft reconstruction to avoid the need for ligation. Collateral venous drainage may be sufficient to allow acceptable results from IVC ligation; however, previous studies have suffered from low numbers and have differing results. The aims of this study were to assess the outcomes of isolated IVC injuries overall and to compare IVC ligation with repair. METHODS: Patients in the National Trauma...
Source: Methods of Information in Medicine - September 9, 2019 Category: Information Technology Authors: Byerly S, Cheng V, Plotkin A, Matsushima K, Inaba K, Magee GA Tags: J Vasc Surg Venous Lymphat Disord Source Type: research

The Differing Effect of Gender and Clinical Specialty on Physicians' Intention to Use Electronic Medical Record.
CONCLUSIONS:  The proposed research framework contributes to the conclusive explanation for interpreting physicians' intention to use EMR. Physicians generally have a higher level of computer literacy. Therefore, the factor of PEOU could not be critical regarding adopting new health information technology (HIT). This study also brings perspectives from the gender, and clinical differences have primarily been missing in the literature of the physicians' intention to use HIT. In doing so, it infers how gender, and clinical specialty, may complement (and in some instances, reinforce) the influence of technological and at...
Source: Methods of Information in Medicine - September 9, 2019 Category: Information Technology Authors: Hwang HG, Dutta B, Chang HC Tags: Methods Inf Med Source Type: research

Clinical Decision-Support Systems for Detection of Systemic Inflammatory Response Syndrome, Sepsis, and Septic Shock in Critically Ill Patients: A Systematic Review.
CONCLUSIONS:  The review demonstrated the high variety of research in this context successfully. A clear trend is observable toward the use of data-driven algorithms, and a lack of research could be identified in covering the pediatric population as well as acknowledging SIRS as an independent and threatening condition. The quality as well as the significance of the presented evaluations for assessing the performances of the algorithms in clinical routine settings are often not meeting the current standard of scientific work. Our future interest will be concentrated on these realistic settings by implementing and eval...
Source: Methods of Information in Medicine - September 9, 2019 Category: Information Technology Authors: Wulff A, Montag S, Marschollek M, Jack T Tags: Methods Inf Med Source Type: research

Laparoscopic Suprapancreatic Lymph Node Dissection Using a Systematic Mesogastric Excision Concept for Gastric Cancer.
CONCLUSIONS: We believe that this laparoscopic suprapancreatic lymphadenectomy using SME takes advantage of the surgical anatomy and achieves en bloc removal of the primary tumor and gastric mesentery. This series is a proof of concept that this procedure can be performed in a timely manner and is feasible. PMID: 31407184 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - August 12, 2019 Category: Information Technology Authors: Kumamoto T, Kurahashi Y, Niwa H, Nakanishi Y, Ozawa R, Okumura K, Ishida Y, Shinohara H Tags: Ann Surg Oncol Source Type: research

Hyper-G: An Artificial Intelligence Tool for Optimal Decision-Making and Management of Blood Glucose Levels in Surgery Patients.
CONCLUSIONS:  Machine learning models are able to accurately predict peak glucose levels during surgery. Implementation of such a model as a web-based application can facilitate optimal decision-making and advance planning of glucose management strategies. PMID: 31398727 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - August 9, 2019 Category: Information Technology Authors: Nair AA, Velagapudi M, Behara L, Venigandla R, Fong CT, Horibe M, Nair BG Tags: Methods Inf Med Source Type: research

Comparison of PSMA-ligand PET/CT and multiparametric MRI for the detection of recurrent prostate cancer in the pelvis.
CONCLUSIONS: PSMA-PET/CT detected more pelvic lesions characteristic for rPC when compared to MRI. In order to detect rPC, a potential future scenario could be conducting first a PSMA-PET/CT. Combining the advantages of both modalities in hybrid PET/MRI scanners would be an ideal future scenario. PMID: 31350604 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - July 27, 2019 Category: Information Technology Authors: Afshar-Oromieh A, Vollnberg B, Alberts I, Bähler A, Sachpekidis C, Dijkstra L, Haupt F, Boxler S, Gross T, Holland-Letz T, Thalmann G, Heverhagen J, Rominger A, Härmä K, Maurer MH Tags: Eur J Nucl Med Mol Imaging Source Type: research

Directions for surgical capacity developments in Nepal: a population-based assessment.
CONCLUSIONS: This study defined four focus areas that showed the largest unmet needs that resulted in a perceived disability. For those areas, affordability, availability, and acceptability of surgical need to be addressed through technical developments, capacity building, and raising awareness. This article is protected by copyright. All rights reserved. PMID: 31328362 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - July 22, 2019 Category: Information Technology Authors: Knulst AJ, Gupta S, Groen RS, Maharjan D, Kapendra AS, Dankelman J, Kushner AL Tags: Trop Med Int Health Source Type: research

The effect of a spectral filter on visual quality in patients with an extended-depth-of-focus intraocular lens.
CONCLUSIONS: Symfony's spectral dependence was observed to affect visual acuity and contrast sensitivity. Although the red filter did not improve distance vision, it caused visual deterioration at near. One might take this effect into account when optimizing the reading performance of patients with diffractive IOLs. PMID: 31323200 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - July 16, 2019 Category: Information Technology Authors: Łabuz G, Auffarth GU, Özen A, van den Berg TJ, Yildirim TM, Son HS, Khoramnia R Tags: Am J Ophthalmol Source Type: research

Pacemaker cell characteristics of differentiated and HCN4-transduced human mesenchymal stem cells.
izer PA Abstract AIMS: Cell-based biological pacemakers aim to overcome limitations and side effects of electronic pacemaker devices. We here developed and tested different approaches to achieve nodal-type differentiation using human adipose- and bone marrow-derived mesenchymal stem cells (haMSC, hbMSC). MAIN METHODS: haMSC and hbMSC were differentiated using customized protocols. Quantitative RT-PCR was applied for transcriptional pacemaker-gene profiling. Protein membrane expression was analyzed by immunocytochemistry. Pacemaker current (If) was studied in haMSC with and without lentiviral HCN4-transduction...
Source: Methods of Information in Medicine - July 7, 2019 Category: Information Technology Authors: Darche FF, Rivinius R, Köllensperger E, Leimer U, Germann G, Seckinger A, Hose D, Schröter J, Bruehl C, Draguhn A, Gabriel R, Schmidt M, Koenen M, Thomas D, Katus HA, Schweizer PA Tags: Life Sci Source Type: research

Effect of Dexmedetomidine-Mediated Insulin-Like Growth Factor 2 (IGF2) Signal Pathway on Immune Function and Invasion and Migration of Cancer Cells in Rats with Ovarian Cancer.
Abstract BACKGROUND The aim of this study was to explore the effect of dexmedetomidine (DEX)-mediated insulin-like growth factor 2 (IGF2) signal pathway on immune function and cancer cell invasion and migration in rats with ovarian cancer. MATERIAL AND METHODS Forty rats with ovarian cancer were divided into 4 groups: model group, and low dose (0.2 μg/kg/hour DEX), medium dose (1.0 μg/kg/hour DEX), and high dose (5.0 μg/kg/hour DEX) DEX groups. In addition, 10 Fischer344 rats were selected as a normal group. Human NUTU-19 poorly differentiated epithelial ovarian cancer cell line cells were divided into 4 ...
Source: Methods of Information in Medicine - June 23, 2019 Category: Information Technology Authors: Tian H, Hou L, Xiong Y, Cheng Q, Huang J Tags: Med Sci Monit Source Type: research

Inhibitory effects of oxymatrine on hepatic stellate cells activation through TGF- β/miR-195/Smad signaling pathway.
In this study, we investigated whether OM could inhibit HSCs activation through TGF-β1/miR-195/Smads signaling or not. METHODS: First, the effects of OM on HSC-T6 in different concentrations and time points were tested by MTT assay. We choose three appropriate concentrations of OM as treatment concentrations in following experiment. By Quantitative Real-time PCR and Western Blot, then we investigated the effect of OM on miR-195, Smad7 and α-SMA's expressions to prove the correlation between OM and the TGF-β1/miR-195/Smads signaling. Last, miR-195 mimic and INF-γ were used to investigate the relat...
Source: Methods of Information in Medicine - June 20, 2019 Category: Information Technology Authors: Song LY, Ma YT, Fang WJ, He Y, Wu JL, Zuo SR, Deng ZZ, Wang SF, Liu SK Tags: BMC Complement Altern Med Source Type: research

[Health and primary care surveillance among asylum seekers in reception centres in Germany: concept, development, and implementation].
CONCLUSIONS: For the first time in Germany, a harmonized infrastructure spanning federal states was implemented in healthcare settings ensuring medical documentation and surveillance of health and healthcare of asylum seekers in conformity with data protection requirements. The surveillance is feasible; the long-term benefits of routine surveillance and research within the network will be assessed in the future. PMID: 31201445 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - June 14, 2019 Category: Information Technology Authors: Nöst S, Jahn R, Aluttis F, Drepper J, Preussler S, Qreini M, Breckenkamp J, Razum O, Bozorgmehr K Tags: Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz Source Type: research

Correlations between P53 Mutation Status and Texture Features of CT Images for Hepatocellular Carcinoma.
CONCLUSIONS:  There was a direct relationship between P53 mutations and gray-level co-occurrence matrix, but not with histograms for HCC patients. Correlation and entropy seemed to be the most promising in differentiating P53 (-) from P53(+). PMID: 31163452 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - June 4, 2019 Category: Information Technology Authors: Wu H, Chen X, Chen J, Luo Y, Jiang X, Wei X, Tang W, Liu Y, Liang Y, Liu W, Guo Y Tags: Methods Inf Med Source Type: research

Assistive Conversational Agent for Health Coaching: A Validation Study.
CONCLUSIONS:  The study provided a set of dimensions when building a human-conversational agent powered health intervention tool. The results provided interesting insights when using human-conversational agent mediated approach in health coaching systems. The findings revealed that users who were highly engaged were also more adherent to conversational-agent activities. This research made key contributions to the literature on techniques in providing social, yet tailored health coaching support: (1) identifying habitual patterns to understand user preferences; (2) the role of a conversational agent in delivering healt...
Source: Methods of Information in Medicine - May 22, 2019 Category: Information Technology Authors: Fadhil A, Wang Y, Reiterer H Tags: Methods Inf Med Source Type: research

Ketoprofen and tramadol pharmacokinetics in patients with chronic pancreatitis.
CONCLUSIONS: Chronic pancreatitis led to a decrease in the total amount of absorbed ketoprofen. Consequently, the analgesic effect of the drug may be weaker. Cmax of tramadol for most CP patients was within the therapeutic range associated with its analgesic activity. M1/TRM ratios for Cmax and AUC were unchanged. PMID: 31115034 [PubMed - in process] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - May 1, 2019 Category: Information Technology Authors: Siepsiak-Połom M, Szałek E, Porażka J, Karbownik A, Grabowski T, Mziray M, Adrych K, Grześkowiak E Tags: Eur Rev Med Pharmacol Sci Source Type: research

Is MRCP necessary to diagnose pancreas divisum?
Abstract BACKGROUND: The purpose of this study is to compare the performance of three-dimensional magnetic resonance cholangiopancreatography (3D-MRCP) with non-MRCP T2-weighted magnetic resonance imaging (MRI) sequences for diagnosis of pancreas divisum (PD). METHODS: This is a retrospective study of 342 consecutive patients with abdominal MRI including 3D-MRCP. 3D-MRCP was a coronal respiration-navigated T2-weighted sequence with 1.5 mm slice thickness. Non-MRCP T2-weighted sequences were (1) a coronal inversion recovery sequence (TIRM) with 6 mm slice thickness and (2) a transverse single sho...
Source: Methods of Information in Medicine - April 29, 2019 Category: Information Technology Authors: Bogveradze N, Hasse F, Mayer P, Rupp C, Tjaden C, Klauss M, Kauczor HU, Weber TF Tags: BMC Med Imaging Source Type: research

Effects of Crinum jagus Water/Ethanol Extract on Shigella flexneri-Induced Diarrhea in Rats.
This study aimed to evaluate anti-Shigella flexneri activities of Crinum jagus water/ethanol extract. In vitro activities were assayed by disc diffusion and agar dilution methods and in vivo section on Shigella flexneri-induced diarrhea in rats. This was done by oral administration of 9 X 108 CFU of Shigella flexneri to rats that were treated twice daily with Crinum jagus water/ethanol extract for seven consecutive days. Ciprofloxacin was used as positive control. Daily Shigella flexneri load was evaluated. After one treatment week, animals were then sacrificed and interleukins (IL-2 and INF-γ), immunoglobulins (IgA ...
Source: Methods of Information in Medicine - April 18, 2019 Category: Information Technology Authors: Noubissi PA, Fokam Tagne MA, Fankem GO, Ngakou Mukam J, Wambe H, Kamgang R Tags: Evid Based Complement Alternat Med Source Type: research

Pharmacokinetics and Abuse Potential of Asalhydromorphone, a Novel Prodrug of Hydromorphone, After Intranasal Administration in Recreational Drug Users.
CONCLUSIONS: The novel hydromorphone prodrug ASAL-HM produced marked reductions in hydromorphone exposure and abuse-related effects following IN administration compared with HM. ASAL-HM has desirable molecular features for incorporation into putative abuse-deterrent immediate-release and extended-release hydromorphone products. PMID: 30986302 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - April 15, 2019 Category: Information Technology Authors: Guenther S, Mickle TC, Barrett AC, Smith A, Braeckman R, Kelsh D, Vince B Tags: Pain Med Source Type: research

Using country of origin to inform targeted tuberculosis screening in asylum seekers: a modelling study of screening data in a German federal state, 2002-2015.
CONCLUSIONS: WHO's TB data can inform the estimation of screening yield and thus be used to improve screening efficiency in asylum seekers. This may help to develop more targeted screening strategies by reducing uncertainty in estimates of expected country-specific yield, and identify thresholds with lowest loss in sensitivity. Further modelling studies are needed which combine clinical, diagnostic and country-specific parameters. PMID: 30943917 [PubMed - in process] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - April 3, 2019 Category: Information Technology Authors: Bozorgmehr K, Preussler S, Wagner U, Joggerst B, Szecsenyi J, Razum O, Stock C Tags: BMC Infect Dis Source Type: research

Research Subjects and Research Trends in Medical Informatics.
CONCLUSIONS:  Beside classical subjects of medical informatics on organizing, representing, and analyzing data, we observed new developments in the context of mobile health and clinical informatics. These subjects tended to grow over the past years, and we can expect this trend to continue. PMID: 30919405 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - March 27, 2019 Category: Information Technology Authors: Gülkesen KH, Haux R Tags: Methods Inf Med Source Type: research

Effect of Serum Deprivation Stress on Signal Induction Regulatory Protein-Alpha (SIRP-Alpha)-Mediated Erythrophagocytosis by Macrophages.
CONCLUSIONS Serum deprivation and LPS/INF-Gamma induction resulted in increased SIRP-alpha expression and erythrophagocytosis. Using SIRP-alpha Ab during this condition decreased the rate of erythrophagocytosis, which indicates that SIRP-alpha receptor can have pro-phagocytic activity. PMID: 30894504 [PubMed - in process] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - March 21, 2019 Category: Information Technology Authors: Hindi Z, Gad A, Jarvis C, Zahoor T, Spellman C, Filleur S Tags: Med Sci Monit Basic Res Source Type: research

Increased volumes of mildly elevated capillary transit time heterogeneity positively predict favorable outcome and negatively predict intracranial hemorrhage in acute ischemic stroke with large vessel occlusion.
CONCLUSION: An increased volume of mildly elevated CTH is a positive predictor of favorable outcome and a negative predictor for ICH in patients with acute ischemic stroke and mismatch undergoing ET. KEY POINTS: • The classification of potentially salvageable tissue and infarct core based on traditional net perfusion parameters (as Tmax or CBF) does not account for the microvascular distribution of blood. • However, the microvascular distribution of blood, as indexed by the capillary transit time heterogeneity (CTH), directly affects the availability of oxygen within the hypoperfused tissue and should theref...
Source: Methods of Information in Medicine - March 18, 2019 Category: Information Technology Authors: Potreck A, Loebel S, Pfaff J, Østergaard L, Mouridsen K, Radbruch A, Bendszus M, Mundiyanapurath S Tags: Eur Radiol Source Type: research

Deep Learning versus Conventional Machine Learning for Detection of Healthcare-Associated Infections in French Clinical Narratives.
CONCLUSIONS:  The main drawback of CNNs is their opacity. To address this issue, we investigated CNN inner layers' activation values to visualize the most meaningful phrases in a document. This method could be used to build a phrase-based medical assistant algorithm to help the infection control practitioner to select relevant medical records. Our study demonstrated that deep learning approach outperforms other classification learning algorithms for automatically identifying HAIs in medical reports. PMID: 30877683 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - March 15, 2019 Category: Information Technology Authors: Rabhi S, Jakubowicz J, Metzger MH Tags: Methods Inf Med Source Type: research

Erratum to: Machine Learning and Data Analytics in Pervasive Health.
Abstract PMID: 30763967 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - February 14, 2019 Category: Information Technology Authors: Oliver N, Mayora O, Marschollek M Tags: Methods Inf Med Source Type: research

The Novel X-Ray Visible Zein-Based Non-adhesive Precipitating Liquid Embolic HEIE1_2017: An Exploratory Study.
CONCLUSION: HEIE1_2017 is a promising novel zein-based liquid embolic. Further preclinical and clinical studies with higher case numbers and long-term follow-up are needed to further assess the value of this embolic material. PMID: 30761410 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - February 13, 2019 Category: Information Technology Authors: Vollherbst DF, Do TD, Jugold M, Eichwald V, Macher-Göppinger S, Pereira PL, Bendszus M, Möhlenbruch MA, Richter GM, Kauczor HU, Sommer CM Tags: Cardiovasc Intervent Radiol Source Type: research

Evaluation of 11C-LSN3172176 as a novel PET tracer for imaging M1 muscarinic acetylcholine receptors in non-human primates.
Conclusion: 11C-LSN3172176 exhibits excellent in vivo binding and imaging characteristics in non-human primates and appears to be the first appropriate radiotracer for PET imaging of human M1 AChR. PMID: 30733324 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - February 7, 2019 Category: Information Technology Authors: Nabulsi NB, Holden D, Zheng MQ, Bois F, Lin SF, Najafzadeh S, Gao H, Ropchan J, Lara-Jaime T, Labaree D, Shirali A, Slieker LJ, Jesudason CD, Barth VN, Navarro A, Kant N, Carson RE, Huang H Tags: J Nucl Med Source Type: research

Simplified disease activity changes in real-world practice: a nationwide observational study of seropositive rheumatoid arthritis patients with moderate-to-high disease activity.
The objective of this study was to compare changes in the simplified disease activity index (SDAI) between biologic (b) and conventional (c) disease-modifying antirheumatic drugs (DMARD) users with seropositive rheumatoid arthritis (RA) in daily clinical practice. Methods: This was a nationwide multicenter observational study. Patients who had three or more active joint counts and abnormal inf lammatory marker in blood test were enrolled. The selection of DMARDs was determined by the attending rheumatologist. Clinical parameters, laboratory findings, and Health Assessment Questionnaire (HAQ) scores were obtained at ba...
Source: Methods of Information in Medicine - January 28, 2019 Category: Information Technology Authors: Shin K, Kim SS, Lee SH, Hong SJ, Choi SJ, Choe JY, Lee SG, Cha HS, Lee EY, Park SH, Hur JW, Na SS, Suh CH, So MW, Choi SW, Sheen DH, Park W, Lee SS, Ryu WH, Kim JS, Song JS, Lee HS, Kim SH, Yoo DH Tags: Korean J Intern Med Source Type: research

The influence of a magnetic field on photon beam radiotherapy in a normal human TK6 lymphoblastoid cell line.
CONCLUSION: A 1.0 Tesla MF does not affect the clonogenicity of TK6 cells irradiated with 1-4 Gy 6MV photons. This supports the use of MRI guided RT, however ongoing research on the interaction of MF and radiotherapy is warranted. PMID: 30654822 [PubMed - in process] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - January 17, 2019 Category: Information Technology Authors: Yudhistiara B, Zwicker F, Weber KJ, Huber PE, Ruehle A, Brons S, Haering P, Debus J, Hauswald SH Tags: Radiat Oncol Source Type: research

Compatibility of 3D printing materials and printing techniques with PAGAT gel dosimetry.
Abstract Polymer gel (PG) dosimetry enables three dimensional (3D) measurement of complex dose distributions. However, PGs are strongly reactive with oxygen and other contaminations, limiting their applicability by the need to use specific container materials. We investigate different 3D printing materials and printing techniques for their compatibility with PG. Suitable 3D printing materials may provide the possibility to perform PG dosimetry in complex-shaped phantoms. 3D printed and PG-filled test vials were irradiated homogenously. The signal response was evaluated with respect to homogeneity and compared to t...
Source: Methods of Information in Medicine - January 16, 2019 Category: Information Technology Authors: Elter A, Dorsch S, Mann P, Runz A, Johnen W, Karger CP Tags: Phys Med Biol Source Type: research

Microbubble-mediated delivery of human adenoviruses does not elicit innate and adaptive immunity response in an immunocompetent mouse model of prostate cancer.
CONCLUSIONS: This study brings us a step closer to demonstrating the feasibility of murine cancer models to investigate the clinical translation of image guided site-specific adenoviral gene therapy mediated by ultrasound-targeted microbubble destruction. PMID: 30635014 [PubMed - in process] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - January 11, 2019 Category: Information Technology Authors: De Carlo F, Thomas L, Brooke B, Varney ET, Nande R, Boskovic O, Marshall GD, Claudio PP, Howard CM Tags: J Transl Med Source Type: research

Addendum to: Approaches to Regularized Regression - A Comparison between Gradient Boosting and the Lasso.
Abstract PMID: 30634196 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - January 11, 2019 Category: Information Technology Authors: Hepp T, Schmid M, Gefeller O, Waldmann E, Mayr A Tags: Methods Inf Med Source Type: research

Combined nitrous oxide 70% with intranasal fentanyl for procedural analgosedation in children: a prospective, randomised, double-blind, placebo-controlled trial.
CONCLUSION: Combining N2O 70% with INF resulted in no differences with regard to FLACC scale score, self-reported pain, MBPS score, patient and parental satisfaction rate, sedation depth, and adverse events. TRIAL REGISTRATION NUMBER: NCT02533908. PMID: 30630844 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - January 10, 2019 Category: Information Technology Authors: Seiler M, Staubli G, Landolt MA Tags: Emerg Med J Source Type: research

Development and dosimetry of 203Pb/212Pb-labelled PSMA ligands: bringing "the lead" into PSMA-targeted alpha therapy?
CONCLUSION: 212Pb-CA012 is a promising candidate for PSMA-targeted alpha therapy of prostate cancer. The dosimetry estimate for radiopharmaceuticals decaying with the release of unstable daughter nuclides has some inherent limitations, thus clinical translation should be done cautiously. PMID: 30603987 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - January 3, 2019 Category: Information Technology Authors: Dos Santos JC, Schäfer M, Bauder-Wüst U, Lehnert W, Leotta K, Morgenstern A, Kopka K, Haberkorn U, Mier W, Kratochwil C Tags: Eur J Nucl Med Mol Imaging Source Type: research

A Pharmacogenomics Clinical Decision Support Service Based on FHIR and CDS Hooks.
CONCLUSIONS:  In conclusion, we have found that PGx CDS based on FHIR and CDS Hooks appears to represent a promising means of genomics-EHR integration. More real-world testing along with a set of use-case driven GACS interface requirements will push us closer to the U.S. National Human Genome Research Institute vision of a plug-in PGx app. PMID: 30605914 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - January 3, 2019 Category: Information Technology Authors: Dolin RH, Boxwala A, Shalaby J Tags: Methods Inf Med Source Type: research

Immunosuppressive therapy influences the accelerated age-dependent T-helper cell differentiation in systemic lupus erythematosus remission patients.
CONCLUSIONS: Our data reveal that the currently used immunosuppressive therapy has a favorable effect on the differentiation and proliferation of Tresps but has a rather unfavorable effect on the proliferation of Tregs. Newer substances with more specific effects on the immune system would be desirable. PMID: 30563559 [PubMed - in process] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - December 18, 2018 Category: Information Technology Authors: Schaier M, Gottschalk C, Uhlmann L, Speer C, Kälble F, Eckstein V, Müller-Tidow C, Meuer S, Mahnke K, Lorenz HM, Zeier M, Steinborn A Tags: Arthritis Res Ther Source Type: research

Role and regulation of proapoptotic Bax in oral squamous cell carcinoma and drug resistance.
CONCLUSION: Hence, the Bax gene alteration and its deregulation through p53/Akt pathway are important for OSCC progression and drug resistance. Akt Inhibitor VIII and nimbolide synergistically induce Bax, and it is therefore beneficial for chemosensitizing cisplatin-resistant human OSCC. PMID: 30549344 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - December 14, 2018 Category: Information Technology Authors: Alam M, Kashyap T, Mishra P, Panda AK, Nagini S, Mishra R Tags: Head Neck Source Type: research

Linking Electronic Health Record and Trauma Registry Data: Assessing the Value of Probabilistic Linkage.
CONCLUSION:  The combination of deterministic and an additional probabilistic method represents a robust approach for linking EHR data to trauma registry data. This approach may be generalizable to studies involving other registries and databases. PMID: 30453337 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - November 19, 2018 Category: Information Technology Authors: Durojaiye AB, Puett LL, Levin S, Toerper M, McGeorge NM, Webster KLW, Deol GS, Kharrazi H, Lehmann HP, Gurses AP Tags: Methods Inf Med Source Type: research

Leveraging Electronic Dental Record Data to Classify Patients Based on Their Smoking Intensity.
CONCLUSION:  EDR data could serve as a valuable source for obtaining patients' detailed smoking information based on their smoking intensity that may not be readily available in the EHR. PMID: 30453338 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - November 19, 2018 Category: Information Technology Authors: Patel J, Siddiqui Z, Krishnan A, Thyvalikakath TP Tags: Methods Inf Med Source Type: research

Electronic Collection of Multilingual Patient-Reported Outcomes across Europe.
CONCLUSIONS:  This study represents the first use of an ePRO system for the collection of multilingual PROs in an international, multicenter setting. MoPat2 has been evaluated by both clinicians and patients in the context of a European dermatological study, resulting in a high user satisfaction. The system will be further developed to include new features such as patient follow-ups outside of the clinical setting. PMID: 30453339 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - November 19, 2018 Category: Information Technology Authors: Soto-Rey I, Rehr M, Bruland P, Zeidler C, Riepe C, Steinke S, Ständer S, Dugas M, Storck M Tags: Methods Inf Med Source Type: research

Pathological tumor infiltrative pattern and sites of initial recurrence in stage II/III gastric cancer: Propensity score matching analysis of a multi-institutional dataset.
CONCLUSIONS: INF may represent an important predictor of recurrence patterns after curative resection of stage II/III gastric cancer. PMID: 30411544 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - November 8, 2018 Category: Information Technology Authors: Nakagawa N, Kanda M, Ito S, Mochizuki Y, Teramoto H, Ishigure K, Murai T, Asada T, Ishiyama A, Matsushita H, Tanaka C, Kobayashi D, Fujiwara M, Murotani K, Kodera Y Tags: Cancer Med Source Type: research

Do Anti-TNF Agents Increase the Risk of Inflammatory Bowel Disease Evolution in Patients with Ankylosing Spondylitis? Real Life Data.
CONCLUSION: Despite the increased risk of new-onset IBD development during the course of AS, paradoxical response to anti-TNF drugs must also be considered as a source that triggers onset of IBD. PMID: 30389147 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - October 30, 2018 Category: Information Technology Authors: Üsküdar Cansu D, Üsküdar Teke H, Temel T, Ertürk A, Kahraman O, Korkmaz C Tags: J Natl Med Assoc Source Type: research

Differences in pregnancy outcomes and obstetric care between asylum seeking and resident women: a cross-sectional study in a German federal state, 2010-2016.
Abstract BACKGROUND: Despite large numbers of asylum seekers, there is a lack of evidence on pregnancy outcomes and obstetric care of asylum seeking women in Germany. METHODS: Cross-sectional study (2010-2016) using administrative data of the main referral hospital for pregnant asylum seekers of the reception center of a large federal state in South Germany. INCLUSION CRITERIA: women aged 12-50 years, admitted in relation to pregnancy, childbirth or post-partum complications. OUTCOMES: differences between asylum seekers and residents in the prevalence of high-risk pregnancy conditions, abortive...
Source: Methods of Information in Medicine - October 24, 2018 Category: Information Technology Authors: Bozorgmehr K, Biddle L, Preussler S, Mueller A, Szecsenyi J Tags: BMC Pregnancy Childbirth Source Type: research

Analysis of Machine Learning Algorithms for Diagnosis of Diffuse Lung Diseases.
CONCLUSIONS:  This work contributes to the analysis and selection of features that can efficiently characterize the DLDs studied. PMID: 30296808 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - October 8, 2018 Category: Information Technology Authors: Cardoso I, Almeida E, Allende-Cid H, Frery AC, Rangayyan RM, Azevedo-Marques PM, Ramos HS Tags: Methods Inf Med Source Type: research

Prehospital Telemedical Emergency Management of Severely Injured Trauma Patients.
CONCLUSION:  The review indicates that TMA and TPN are accompanying telemedical concepts in out-of-hospital trauma care. Well-designed populated studies are needed to fully assess the effect of telemedicine in acute trauma care. Therefore, evidence regarding the effectiveness of telemedicine in prehospital setting for trauma patients is still limited. PMID: 30296809 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - October 8, 2018 Category: Information Technology Authors: Eder PA, Reime B, Wurmb T, Kippnich U, Shammas L, Rashid A Tags: Methods Inf Med Source Type: research

A technique for total skin electron therapy (TSET) of an anesthetized pediatric patient.
CONCLUSION: TSET can be delivered to pediatric patients using a customized couch top on a conventional linear accelerator. PMID: 30267453 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - September 29, 2018 Category: Information Technology Authors: Kron T, Donahoo G, Lonski P, Wheeler G Tags: J Appl Clin Med Phys Source Type: research

Cytokines in relation to hCG are significantly altered in asymptomatic women with miscarriage - a pilot study.
CONCLUSIONS: We have shown that cytokines in relation to hCG after 4 weeks of gestation are significantly altered in women with miscarriage, promising potential as a prognostic biomarker. PMID: 30266090 [PubMed - in process] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - September 28, 2018 Category: Information Technology Authors: Freis A, Schlegel J, Daniel V, Jauckus J, Strowitzki T, Germeyer A Tags: Reprod Biol Endocrinol Source Type: research

Beneficial effects of probiotic combination with omega-3 fatty acids in NAFLD: a randomized clinical study.
Abstract BACKGROUND: The manipulation of gut microbiota via administration of probiotics has been proposed as a potential strategy for the treatment of non-alcoholic fatty liver disease (NAFLD). Hence, we performed a double-blind single center randomized placebo-controlled trial (RCT) to evaluate the efficacy of co-administration of probiotics with omega-3 vs. placebo in type-2 diabetic patients with NAFLD. METHODS: A total of 48 patients met the criteria for inclusion. They were randomly assigned to receive "Symbiter Omega" combination of probiotic biomass supplemented with flax and wheat germ oil ...
Source: Methods of Information in Medicine - September 13, 2018 Category: Information Technology Authors: Kobyliak N, Abenavoli L, Falalyeyeva T, Mykhalchyshyn G, Boccuto L, Kononenko L, Kyriienko D, Komisarenko I, Dynnyk O Tags: Minerva Med Source Type: research