Roles of AhR/CYP1s Signal Pathway Mediated ROS Production in Uremic Cardiomyopathy
CONCLUSION: This study provides evidence that the AhR/CYP1s pathway is activated in UCM rats, and this activation is correlated with the uremic toxin IS. In vitro studies indicate that IS can stimulate the AhR translocation in cardiomyocyte, triggering to the production of intracellular ROS via CYP1s. This process leads to prolonged oxidative stress stimulation and thus contributes to the progression of uremic toxin-mediated cardiomyopathy.PMID:38670245 | DOI:10.1016/j.toxlet.2024.04.005 (Source: Toxicology Letters)
Source: Toxicology Letters - April 26, 2024 Category: Toxicology Authors: Wei Lu Shi Cheng Jiarui Xu Zilong Xiao Yong Yu Qiwen Xie Yi Fang Ruizhen Chen Bo Shen Yeqing Xie Xiaoqiang Ding Source Type: research
Cardiovascular Arrest Due to Postrenal Kidney Injury
Dtsch Arztebl Int. 2024 Mar 22;121(6):181. doi: 10.3238/arztebl.m2023.0105.NO ABSTRACTPMID:38666671 | DOI:10.3238/arztebl.m2023.0105 (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - April 26, 2024 Category: General Medicine Authors: Juri Mattern Marc-Sebastian Baier J ürgen Majolk Source Type: research
Association of the trimethylamine N-oxide with cardiovascular risk and vascular alterations in middle-aged patients with risk factors for cardiovascular diseases
Conclusions: TMAO levels are increased with expanded CVD risk. Across different types of vascular damage, TMAO is associated with atherosclerotic changes.PMID:38669041 | DOI:10.1042/BSR20232090 (Source: Bioscience Reports)
Source: Bioscience Reports - April 26, 2024 Category: Biomedical Science Authors: Natalia Spasova Desislava Somleva Bozhidar Krastev Radostina Ilieva Angelina Borizanova Dobrin Svinarov Elena Kinova Assen Goudev Source Type: research
Transition from pediatrics to adult health care in girls with turner syndrome
Expert Rev Endocrinol Metab. 2024 Apr 25:1-12. doi: 10.1080/17446651.2024.2347265. Online ahead of print.ABSTRACTINTRODUCTION: Turner Syndrome is a rare condition secondary to a complete or partial loss of one X chromosome, leading to a wide spectrum of clinical manifestations. Short stature, gonadal dysgenesis, cardiovascular malformations, and dysmorphic features characterize its common clinical picture.AREAS COVERED: The main endocrine challenges in adolescent girls with Turner Syndrome are puberty induction (closely intertwined with growth) and fertility preservation. We discuss the most important clinical aspects that...
Source: Expert Review of Endocrinology and Metabolism - April 26, 2024 Category: Endocrinology Authors: Chiara Sabbadin Loris Marin Jacopo Manso Chiara Mozzato Valentina Camozzi Alessandra Andrisani Cinzia Sacchetti Caterina Mian Carla Scaroni Laura Guazzarotti Filippo Ceccato Source Type: research
Role of cyclophilin A in aggravation of myocardial ischemia reperfusion injury via regulation of apoptosis mediated by thioredoxin-interacting protein
CONCLUSION: These findings highlight the critical role CypA plays in myocardial injury caused by oxidative stress-induced apoptosis, indicating that CypA can be a viable biomarker and a therapeutic target candidate for MI/RI.PMID:38669522 | DOI:10.3233/CH-242142 (Source: Work)
Source: Work - April 26, 2024 Category: Occupational Health Authors: Madina Mahesutihan Ju Yan Hasidaer Midilibieke Li Yu Reyizha Dawulin Wen-Xian Yang Muhuyati Wulasihan Source Type: research
Impact of Prior COVID-19 Infections on Cardiac Rehabilitation Completion Rates and Outcomes
CONCLUSIONS: Having a prior COVID-19 infection did not negatively impact the mental and physical health benefits obtained by completing the CR program, regardless of the American Association of Cardiovascular and Pulmonary Rehabilitation risk category.PMID:38669342 | DOI:10.1097/HCR.0000000000000841 (Source: Journal of Cardiopulmonary Rehabilitation and Prevention)
Source: Journal of Cardiopulmonary Rehabilitation and Prevention - April 26, 2024 Category: Rehabilitation Authors: Matthew A Taylor Julia L Berkowitz Kevin Chen Julianne DeAngelis Wen-Chih Wu Source Type: research
Pulmonary Rehabilitation: Refer Patients Earlier to Enhance Outcomes
J Cardiopulm Rehabil Prev. 2024 Apr 29. doi: 10.1097/HCR.0000000000000875. Online ahead of print.NO ABSTRACTPMID:38669313 | DOI:10.1097/HCR.0000000000000875 (Source: Journal of Cardiopulmonary Rehabilitation and Prevention)
Source: Journal of Cardiopulmonary Rehabilitation and Prevention - April 26, 2024 Category: Rehabilitation Authors: Brian Carlin Joel W Hughes Source Type: research
County-Level Cardiac Rehabilitation and Broadband Availability: Opportunities for Hybrid Care in the United States
CONCLUSIONS: Almost half of US adults live in CR deserts. Given that up to 97% of adults living in CR deserts may have broadband access, implementation of hybrid CR programs that include a telehealth component could expand CR availability to as many as 113 million US adults.PMID:38669319 | DOI:10.1097/HCR.0000000000000865 (Source: Journal of Cardiopulmonary Rehabilitation and Prevention)
Source: Journal of Cardiopulmonary Rehabilitation and Prevention - April 26, 2024 Category: Rehabilitation Authors: David L DeLara Lisa M Pollack Hilary K Wall Anping Chang Linda Schieb Kevin Matthews Haley Stolp Quinn R Pack Michele Casper Sandra L Jackson Source Type: research
Clinician perspectives regarding CYP2C19 genotype testing in patients with critical limb ischemia: A Delphi approach
CONCLUSIONS: PAD interventionalists practicing at an academic health system recognize the heterogenous response of their patients to clopidogrel therapy but are unsure when to leverage genetic testing to improve outcomes for their patients. Our study identified gaps regarding PAD interventionalists' knowledge, perceived barriers, and attitudes toward CYP2C19 testing in PAD. This information highlights the need for randomized data on genetic testing for clopidogrel responsiveness in peripheral vascular disease following intervention to help guide antiplatelet management.PMID:38669051 | DOI:10.1177/17085381241246318 (Source: Vascular)
Source: Vascular - April 26, 2024 Category: Surgery Authors: Christopher Regan Lindsey E Scierka Alan Dardik Britt Tonnessen Cassius Iyad Ochoa Chaar Costin Ionescu Edouard Aboian Jonathan Cardella Naiem Nassiri Raul Guzman Robert Attaran Sameer Nagpal Samit Shah Kim G Smolderen Carlos Mena-Hurtado Source Type: research
Exploring Regular Exercisers' Experiences with Readiness/Recovery Scores Produced by Wearable Devices: A Descriptive Qualitative Study
This study explores individuals' experiences with wearable devices and their associated readiness or recovery scores. Seventeen regular exercisers who owned and used a Whoop™ band or Oura™ ring for at least 3 months participated in a one-on-one virtual semi-structured interview. Interviews were analyzed using reflexive thematic analysis, with themes supported by 'in-vivo' quotes. This paper focuses on three key themes for a comprehensive demonstration. Theme 1, 'It's more about how I can make adjustments to optimize my programming,' (MPR) highlights users' intended use of wearables for guiding training decisions. Theme...
Source: Applied Psychophysiology and Biofeedback - April 26, 2024 Category: Psychiatry & Psychology Authors: Adam H Ibrahim Cory T Beaumont Kelley Strohacker Source Type: research
Association of the trimethylamine N-oxide with cardiovascular risk and vascular alterations in middle-aged patients with risk factors for cardiovascular diseases
Conclusions: TMAO levels are increased with expanded CVD risk. Across different types of vascular damage, TMAO is associated with atherosclerotic changes.PMID:38669041 | DOI:10.1042/BSR20232090 (Source: Atherosclerosis)
Source: Atherosclerosis - April 26, 2024 Category: Cardiology Authors: Natalia Spasova Desislava Somleva Bozhidar Krastev Radostina Ilieva Angelina Borizanova Dobrin Svinarov Elena Kinova Assen Goudev Source Type: research
Non-Invasive Assessment of Micro- and Macrovascular Function after Initiation of JAK Inhibitors in Patients with Rheumatoid Arthritis
CONCLUSIONS: Three-month treatment with JAK inhibitors may exert significant effects on microcirculation as assessed with nailfold videocapillaroscopy, whereas macrovascular structure and function appears largely unaffected. Further research toward this direction may add substantial information to the available literature regarding cardiovascular aspects of JAK inhibitors in RA.PMID:38667479 | DOI:10.3390/diagnostics14080834 (Source: Atherosclerosis)
Source: Atherosclerosis - April 26, 2024 Category: Cardiology Authors: Panagiota Anyfanti Elena Angeloudi Athanasia Dara Eleni Pagkopoulou Georgia-Savina Moysidou Kleopatra Deuteraiou Maria Boutel Eleni Bekiari Michael Doumas George D Kitas Theodoros Dimitroulas Source Type: research
Decreased Ubiquitination and Acetylation of Histones 3 and 4 Are Associated with Obesity-Induced Disorders of Spermatogenesis in Mice
CONCLUSION: These results suggest that low levels of histone ubiquitination and acetylation are linked with obesity-induced disorders during spermatogenesis, contributing to a better understanding of obesity-induced damage to male reproduction.PMID:38668519 | DOI:10.3390/toxics12040296 (Source: Cancer Control)
Source: Cancer Control - April 26, 2024 Category: Cancer & Oncology Authors: Mahamadou Fofana Zhenyang Li Han Li Wenqi Li Lu Wu Lu Lu Qizhan Liu Source Type: research
Hypertension Prevalence and Control Among People With and Without HIV - United States, 2022
CONCLUSIONS: PWH were more likely to have hypertension than people without HIV. Geographic and racial disparities in hypertension prevalence and control were observed among PWH. Optimal care for PWH includes comprehensive strategies to screen for, prevent, and manage hypertension.PMID:38668635 | DOI:10.1093/ajh/hpae048 (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - April 26, 2024 Category: Cardiology Authors: Xingran Weng Lyudmyla Kompaniyets Kate Buchacz Angela M Thompson-Paul Rebecca C Woodruff Karen W Hoover Ya-Lin A Huang Jun Li Sandra L Jackson Source Type: research
Association of Cardiovascular Health in Young Adulthood with Long-Term Blood Pressure Trajectories
CONCLUSIONS: Moderate or low CVH status in YA is associated with elevated mid-life BP trajectory. These data suggest that young adult CVH promotion may be important for primordial prevention of hypertension.PMID:38666584 | DOI:10.1093/ajh/hpae047 (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - April 26, 2024 Category: Cardiology Authors: James W Guo Hongyan Ning Norrina B Allen Orna Reges Kelley Pettee Gabriel Donald M Lloyd-Jones Source Type: research
