Amplification of Salt-Sensitive Hypertension and Kidney Damage by Immune Mechanisms.
Abstract Humans with salt-sensitive hypertension demonstrate increased morbidity, increased mortality, and renal end-organ damage when compared to normotensive subjects or those with salt-resistant hypertension. Increasing evidence indicates that immune mechanisms play an important role in the full development of salt-sensitive hypertension and associated renal damage. Recent experimental advances and studies in animal models have permitted a greater understanding of the mechanisms of activation and action of immunity in this disease process. Evidence favors a role of both innate and adaptive immune mechanisms tha...
Source: American Journal of Hypertension - July 29, 2020 Category: Cardiology Authors: Mattson DL, Dasinger JH, Abais-Battad JM Tags: Am J Hypertens Source Type: research

Integrating qualitative factors to face the challenges of medication adherence in patients with hypertension.
acute;jar T PMID: 32725196 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - July 29, 2020 Category: Cardiology Authors: Arredondo A, Recamán AL, Véjar T Tags: Am J Hypertens Source Type: research

Blood Pressure Variability and Dementia: A State-of-the-art Review.
Abstract Accumulating evidence demonstrates that blood pressure variability (BPV) may contribute to target organ damage, causing coronary heart disease, stroke, and renal disease independent of the level of BP. Several lines of evidence have also linked increased BPV to a higher risk of cognitive decline and incident dementia. The estimated number of dementia cases worldwide is nearly 50 million, and this number continues to grow with increasing life expectancy. Because there is no effective treatment to modify the course of dementia, targeting modifiable vascular factors continues as a top priority for dementia p...
Source: American Journal of Hypertension - July 25, 2020 Category: Cardiology Authors: Ma Y, Tully PJ, Hofman A, Tzourio C Tags: Am J Hypertens Source Type: research

A Clinical Prediction Model of Medication Adherence in Hypertensive Patients in a Chinese Community Hospital in Beijing.
CONCLUSIONS: Our data provide new insights into the improvements of the compliance to antihypertensive medications, which is beneficial for the management of hypertension, and the compliance predictive model may be used in community-based hypertension management. PMID: 32710736 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - July 25, 2020 Category: Cardiology Authors: Gao W, Liu H, Ge C, Liu X, Jia H, Wu H, Peng X Tags: Am J Hypertens Source Type: research

Maternal hypertension-related genotypes and congenital heart defects.
CONCLUSIONS: We replicated a previously reported association between rs633185 and conotruncal defects. Although additional hypertension-related SNPs were also associated with congenital heart defects, more work is needed to better understand the relationship between genetic risk for maternal hypertension and congenital heart defects occurrence. PMID: 32710738 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - July 25, 2020 Category: Cardiology Authors: Lei Y, Ludorf KL, Yu X, Benjamin RH, Gu X, Lin Y, Finnell RH, Mitchell LE, Musfee FI, Malik S, Canfield MA, Morrison AC, Hobbs CA, Van Zutphen AR, Fisher S, Agopian AJ, National Birth Defects Prevention Study Tags: Am J Hypertens Source Type: research

Short-term but not long-term blood pressure variability is a predictor of adverse cardiovascular outcomes in young untreated hypertensives.
CONCLUSIONS: In young hypertensive subjects only short-term BPV resulted a significant predictor of MACE on top of traditional ABPM parameters. Whether reduction of short-term BPV with therapy may reduce the cardiovascular risk independently from the effects on 24h BP is a matter for future research. PMID: 32710778 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - July 25, 2020 Category: Cardiology Authors: Saladini F, Fania C, Mos L, Vriz O, Mazzer A, Spinella P, Garavelli G, Ermolao A, Rattazzi M, Palatini P Tags: Am J Hypertens Source Type: research

Comparison of Three Devices for 24-hour Ambulatory Blood Pressure Monitoring in a Nonclinical Environment Through a Randomized Trial.
Abstract BACKGROUND: The U.S. Preventive Services Task Force recommends the use of 24-hour ambulatory blood pressure monitoring (ABPM) as part of screening and diagnosis of hypertension. The optimal ABPM device for population-based surveys is unknown. OBJECTIVE: Among three ABPM devices, we compared the proportion of valid BP readings, mean awake and asleep BP readings, differences between awake ABPM readings and initial standardized BP readings, and sleep experience. RESULTS: The proportions of valid blood pressure readings were not different among the three devices ( p> 0.45). Mean awake and asleep sy...
Source: American Journal of Hypertension - July 23, 2020 Category: Cardiology Authors: Nwankwo T, Coleman King SM, Ostchega Y, Zhang G, Loustalot F, Gillespie C, Chang TE, Begley EB, George MG, Shimbo D, Schwartz JE, Muntner P, Kronish IM, Hong Y, Merritt R Tags: Am J Hypertens Source Type: research

Using predicted atherosclerotic cardiovascular disease risk for discrimination of awake or nocturnal hypertension.
Abstract BACKGROUND: Several atherosclerotic cardiovascular disease (ASCVD) risk factors are associated with awake and nocturnal hypertension. METHODS: We assessed the association between a composite ASCVD risk score and awake or nocturnal hypertension using data from participants aged 40-79 years who completed ambulatory blood pressure monitoring at the Year 30 Coronary Artery Risk Development in Young Adults study exam in 2015-2016 (n=716) and the baseline Jackson Heart Study exam in 2000-2004 (n=770). Ten-year predicted ASCVD risk was calculated using the Pooled Cohort risk equations. Awake hypertension wa...
Source: American Journal of Hypertension - July 13, 2020 Category: Cardiology Authors: Sakhuja S, Booth Iii JN, Anstey DE, Jaeger BC, Lewis CE, Lloyd-Jones DM, Schwartz JE, Shimbo D, Shikany JM, Sims M, Muntner P Tags: Am J Hypertens Source Type: research

Age-specific acute changes in carotid-femoral pulse wave velocity with head-up tilt.
Abstract BACKGROUND: Aortic stiffness as measured by carotid-femoral pulse wave velocity (cfPWV) is known to depend on blood pressure (BP), and this dependency may change with age. Therefore, the hydrostatic BP gradient resulting from a change in body posture may elicit a cfPWV change that is age-dependent. We aimed to analyze the relationship between BP gradient - induced by head-up body tilting - and related changes in cfPWV in individuals of varying age. METHODS: cfPWV and other hemodynamic parameters were measured in 30 healthy individuals at a head-up tilt of 0° (supine), 30°, and 60°. At eac...
Source: American Journal of Hypertension - July 7, 2020 Category: Cardiology Authors: Pucci G, Spronck B, Avolio AP, Tap L, Vaudo G, Anastasio F, Van Den Meiracker A, Mattace-Raso F Tags: Am J Hypertens Source Type: research

The renal dangers of an increased Cardio-Ankle Vascular Index.
one S PMID: 32629473 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - July 7, 2020 Category: Cardiology Authors: MulÈ' G, Sinatra N, Vario MG, Vadala' M, Cottone S Tags: Am J Hypertens Source Type: research

The Road to Implementing Home Blood Pressure Monitoring: Are We There Yet?
PMID: 32629475 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - July 7, 2020 Category: Cardiology Authors: Anstey DE, Bradley C, Shimbo D Tags: Am J Hypertens Source Type: research

Effect of lower blood pressure goals on left ventricular structure and function in patients with subclinical hypertensive heart disease.
EFFECT OF LOWER BLOOD PRESSURE GOALS ON LEFT VENTRICULAR STRUCTURE AND FUNCTION IN PATIENTS WITH SUBCLINICAL HYPERTENSIVE HEART DISEASE. Am J Hypertens. 2020 Jul 05;: Authors: Levy PD, Burla MJ, Twiner M, Marinica AL, Mahn JJ, Reed B, Brody A, Ehrman R, Brodsky A, Zhang Y, Nasser SA, Flack JM Abstract BACKGROUND: Subclinical hypertensive heart disease (SHHD) is a precursor to heart failure. Blood pressure (BP) reduction is an important component of secondary disease prevention in patients with SHHD. Treating patients with SHHD utilizing a more intensive BP target (120/80 mm Hg), may lead to improved c...
Source: American Journal of Hypertension - July 5, 2020 Category: Cardiology Authors: Levy PD, Burla MJ, Twiner M, Marinica AL, Mahn JJ, Reed B, Brody A, Ehrman R, Brodsky A, Zhang Y, Nasser SA, Flack JM Tags: Am J Hypertens Source Type: research

Dietary Sodium Intake and Sodium Density in the United States - Estimates from NHANES 2005-2006 and 2015-2016.
Abstract BACKGROUND: In the United States, current guidelines recommend a total sodium intake
Source: American Journal of Hypertension - July 3, 2020 Category: Cardiology Authors: Hu JR, Sahni S, Mukamal KJ, Millar CL, Wu Y, Appel LJ, Juraschek SP Tags: Am J Hypertens Source Type: research

Microbiota and hypertension: role of the sympathetic nervous system and the immune system.
Abstract There are numerous studies indicating a direct association between hypertension and gut microbiota in both animal models and humans. In this review we focused on the imbalance in the gut microbiota composition relative to healthy state or homeostasis, termed dysbiosis, associated with hypertension and discuss the current knowledge regarding how microbiota regulates blood pressure, involving the sympathetic nervous system and the immune system. The profile of ecological parameters and bacterial genera composition of gut dysbiosis in hypertension varies according to the experimental model of hypertension. R...
Source: American Journal of Hypertension - July 2, 2020 Category: Cardiology Authors: Robles-Vera I, Toral M, Duarte J Tags: Am J Hypertens Source Type: research

Artificial Intelligence and Hypertension: Recent Advances and Future Outlook.
Abstract Prevention and treatment of hypertension (HTN) is a challenging public health problem. Recent evidence suggests that artificial intelligence (AI) has potential to be a promising tool for reducing the global burden of HTN, and furthering precision medicine related to cardiovascular (CV) diseases including HTN. Since AI can stimulate human thought processes and learning with complex algorithms and advanced computational power, AI can be applied to multimodal and big data, including genetics, epigenetics, proteomics, metabolomics, CV imaging, socioeconomic, behavioral and environmental factors. AI demonstrat...
Source: American Journal of Hypertension - July 2, 2020 Category: Cardiology Authors: Chaikijurajai T, Laffin LJ, Tang WHW Tags: Am J Hypertens Source Type: research

Factors associated with physician recommendation of home blood pressure monitoring and blood pressure in the US population.
CONCLUSIONS: HBPM use was associated with lower BP and higher medication adherence. Use of HBPM was higher among those with a physician recommendation. These results support a role for physicians in counseling and partnering with patients on HBPM use for BP management. PMID: 32542320 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - June 15, 2020 Category: Cardiology Authors: Tang O, Foti K, Miller ER, Appel LJ, Juraschek SP Tags: Am J Hypertens Source Type: research

Antihypertensive Drugs and Risk of Cancer. Between Scylla and Charybdis.
Abstract Antihypertensive drugs namely angiotensin converting enzyme (ACE) inhibitors, angiotensin II receptor blockers (ARBs), calcium channel blockers (CCBs), beta blockers and diuretics are among the most clearly documented regimens worldwide with an overall cardioprotective benefit. Given that malignancy is the second leading cause of mortality, numerous observational studies aimed to investigate the carcinogenic potential of these agents with conflicting results. The purpose of this review was to summarize current data in an effort to explore rare side effects and new mechanisms linking antihypertensive drugs...
Source: American Journal of Hypertension - June 12, 2020 Category: Cardiology Authors: Sanidas E, Velliou M, Papadopoulos D, Fotsali A, Iliopoulos D, Mantzourani M, Toutouzas K, Barbetseas J Tags: Am J Hypertens Source Type: research

Association of arterial stiffness with kidney function among adults without chronic kidney disease.
Abstract BACKGROUND: Our aims were to assess whether arterial stiffness is associated with a higher risk for kidney dysfunction among persons without chronic kidney disease (CKD). METHODS: We analyzed data from the national health check-up system in Japan; for our analyses, we selected records of individuals who completed assessments of cardio-ankle vascular index (CAVI) and kidney function from 2005 to 2016. We excluded participants who had CKD at baseline, defined as the presence of proteinuria or estimated glomerular filtration rate (eGFR)
Source: American Journal of Hypertension - June 12, 2020 Category: Cardiology Authors: Itano S, Yano Y, Nagasu H, Tomiyama H, Kanegae H, Makino H, Higashi Y, Kobayashi Y, Sogawa Y, Satoh M, Suzuki K, Townsend RR, Budoff M, Bakris G, Kashihara N Tags: Am J Hypertens Source Type: research

Associations between day-by-day home blood pressure variability and renal function and albuminuria in patients with and without diabetes.
Abstract BACKGROUND: The phenotype of diabetic kidney disease represents a lower estimated glomerular filtration rate (eGFR) and albuminuria. We investigated the association between day-by-day home blood pressure (BP) variability and the eGFR in subjects with diabetes and compared this association with that in subjects without diabetes. We then attempted to determine whether the association is present in albuminuria. METHODS: We analyzed 4,231 patients with risk factors of cardiovascular disease (24.4% with diabetes) from the J-HOP (Japan Morning Surge-Home blood pressure) study. Home BP was measured in the m...
Source: American Journal of Hypertension - June 12, 2020 Category: Cardiology Authors: Suzuki D, Hoshide S, Kario K Tags: Am J Hypertens Source Type: research

The Peripheral Nervous System and Changes in Blood Pressure: Lights and Darkness.
eltrán-Romero LM PMID: 32521544 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - June 10, 2020 Category: Cardiology Authors: Stiefel P, Muñoz-Hernández R, Alfaro-Lara V, González-Estrada A, Espinosa-Torre F, Beltrán-Romero LM Tags: Am J Hypertens Source Type: research

Potential impact of the 2017 high blood pressure guideline beyond the United States: A case study of the People's Republic of China.
CONCLUSIONS: The 2017 ACC/AHA guideline brings potential for risk reduction in China and selectively recommends medication for those who would benefit most. Realizing such benefits would ultimately depend on the acceptance, adherence and feasibility of adopting this guideline. PMID: 32521545 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - June 10, 2020 Category: Cardiology Authors: Barszczyk A, Yang D, Wei J, Huang W, Feng ZP, Lee K, Luo H Tags: Am J Hypertens Source Type: research

Cuff-less, personal, ambulatory blood pressure devices and disruption of existing blood pressure measurement paradigms.
PMID: 32515800 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - June 9, 2020 Category: Cardiology Authors: van Helmond N, Day W, Martin SS, Plante TB Tags: Am J Hypertens Source Type: research

Use of RAAS inhibitors and risk of clinical deterioration in COVID-19: results from an Italian cohort of 133 hypertensives.
CONCLUSIONS: Our data suggest that chronic use of RAAS inhibitors does not negatively affect clinical course of COVID-19 in hypertensive patients. Further studies are needed to confirm this finding and determine whether RAAS inhibitors may have a protective effect on COVID 19-related morbidity and mortality. PMID: 32511678 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - June 8, 2020 Category: Cardiology Authors: Felice C, Nardin C, Di Tanna GL, Grossi U, Bernardi E, Scaldaferri L, Romagnoli M, Tonon L, Cavasin P, Novello S, Scarpa R, Farnia A, De Menis E, Rigoli R, Cinetto F, Pauletto P, Agostini C, Rattazzi M Tags: Am J Hypertens Source Type: research

Advances and challenges in the electrocardiographic diagnosis of left ventricular hypertrophy in hypertensive individuals.
PMID: 32506126 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - June 7, 2020 Category: Cardiology Authors: Kabutoya T, Hoshide S, Kario K Tags: Am J Hypertens Source Type: research

TNF α and Reactive Oxygen Signaling in Vascular Smooth Muscle Cells in Hypertension and Atherosclerosis.
TNFα and Reactive Oxygen Signaling in Vascular Smooth Muscle Cells in Hypertension and Atherosclerosis. Am J Hypertens. 2020 Jun 05;: Authors: Lamb FS, Choi H, Miller MR, Stark RJ Abstract Hypertension and atherosclerosis, the predecessors of stroke and myocardial infarction, are chronic vascular inflammatory reactions. Tumor necrosis factor alpha (TNFα), the "master" pro-inflammatory cytokine, contributes to both the initiation and maintenance of vascular inflammation. TNFα induces reactive oxygen species (ROS) production which drives the redox reactions that constitute &q...
Source: American Journal of Hypertension - June 5, 2020 Category: Cardiology Authors: Lamb FS, Choi H, Miller MR, Stark RJ Tags: Am J Hypertens Source Type: research

Association of Obstructive Sleep Apnea with Nighttime Blood Pressure in African Americans: the Jackson Heart Study.
We examined the association of OSA with nighttime BP among African Americans who completed 24-hour ambulatory BP monitoring at Exam 1 (2000-2004) of the Jackson Heart Study (JHS) and subsequently participated in the JHS Sleep Study (2012-2016). Type 3 home sleep apnea testing was used to assess OSA measures, including respiratory event index (REI4%) and percent sleep time
Source: American Journal of Hypertension - June 3, 2020 Category: Cardiology Authors: Thomas SJ, Johnson DA, Guo N, Abdalla M, Booth JN, Spruill TM, Jackson CL, Yano Y, Sims M, Calhoun D, Muntner P, Redline S Tags: Am J Hypertens Source Type: research

MiR-17 knockdown promotes vascular smooth muscle cell phenotypic modulation through upregulated interferon regulator factor 9 expression.
CONCLUSIONS: Taken together, our results demonstrated that miR-17 knockdown accelerated VSMC phenotypic modulation partially through directly targeting to IRF9, which suggested that miR-17 may act as a novel therapeutic target for intimal hyperplasia management. PMID: 32484213 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - June 2, 2020 Category: Cardiology Authors: Li W, Wang J, Li Z Tags: Am J Hypertens Source Type: research

Performance of Electrocardiographic Criteria for Echocardiographically Diagnosed Left Ventricular Hypertrophy in Chinese Hypertensive Patients.
Abstract BACKGROUND: Performance of electrocardiographic (ECG) criteria for echocardiographically diagnosed left ventricular hypertrophy (LVH) in Chinese hypertensive patients is not well known. We investigated the accuracy of various ECG criteria for the diagnosis of the echocardiographic LVH according to the new cutoff values of left ventricular mass (LVM) index (>115 g/m2 for men and>95 g/m2 for women) in Chinese hypertensive patients. METHODS: Our study included 702 consecutive hypertensive inpatients including 92 (13.1%) concentric and 121 (17.2%) eccentric LVH on standard echocardiography. Diagnos...
Source: American Journal of Hypertension - June 2, 2020 Category: Cardiology Authors: Wang D, Xu JZ, Zhang W, Chen Y, Li J, An Y, Bian R, Wang JG Tags: Am J Hypertens Source Type: research

Hyperhomocysteinemia-induced oxidative stress aggravates renal damage in hypertensive rats.
CONCLUSIONS: HHcy appears to synergistically increase hypertensive renal damage by enhancing oxidative stress. PMID: 32484231 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - June 2, 2020 Category: Cardiology Authors: Gao N, Zhang Y, Li L, Lei L, Cao P, Zhao X, Lin L, Xu R Tags: Am J Hypertens Source Type: research

Chemerin as a driver of hypertension: a consideration.
Abstract The protein chemerin (tazarotene induced gene, TIG2; RARRES2) is a relatively new adipokine. Many studies support that circulating chemerin levels associate strongly and positively with BMI, visceral fat and blood pressure. Here, we focus on the specific relationship of chemerin and blood pressure with the goal of understanding whether and how chemerin drives (pathological) changes in blood pressure such that it could be interfered with therapeutically. We dissect the biosynthesis of chemerin and how current antihypertensive medications change chemerin metabolism. This is followed with a review of what is...
Source: American Journal of Hypertension - May 26, 2020 Category: Cardiology Authors: Ferland DJ, Mullick AE, Watts SW Tags: Am J Hypertens Source Type: research

Cost-Related Antihypertensive Medication Nonadherence:Action in the Time of COVID-19 and Beyond.
PMID: 32449903 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - May 25, 2020 Category: Cardiology Authors: Tajeu GS, Muntner P Tags: Am J Hypertens Source Type: research

Response to: Socioeconomic Status and Hypertension in African Americans from the Jackson Heart Study.
PMID: 32434217 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - May 21, 2020 Category: Cardiology Authors: Sims M, Glover LM, Gebreab SY Tags: Am J Hypertens Source Type: research

Unraveling the prevalence of Angiotensin II type 1 receptor antibodies in hypertension.
PMID: 32432661 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - May 20, 2020 Category: Cardiology Authors: Philippe A Tags: Am J Hypertens Source Type: research

Aortic Hemodynamics and Cognitive Performance in Postmenopausal Women: Impact of Pregnancy History.
CONCLUSIONS: Elevated aortic hemodynamics may negatively impact cognitive function in postmenopausal women with specific executive functions, such as letter fluency, being impacted more by a pregnancy history of PE. PMID: 32421781 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - May 18, 2020 Category: Cardiology Authors: Miller KB, Fields JA, Harvey RE, Lahr BD, Bailey KR, Joyner MJ, Miller VM, Barnes JN Tags: Am J Hypertens Source Type: research

Prognostic Value of Masked Uncontrolled Hypertension Defined by Different Ambulatory Blood Pressure Criteria.
CONCLUSIONS: The prognostic impact of MUCH defined according to various ambulatory BP definitions may be different. PMID: 32421785 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - May 18, 2020 Category: Cardiology Authors: Coccina F, Pierdomenico AM, Cuccurullo C, Pizzicannella J, Madonna R, Trubiani O, Cipollone F, Pierdomenico SD Tags: Am J Hypertens Source Type: research

COVID-19 and ACEI/ARB: NOT ASSOCIATED?
PMID: 32415832 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - May 16, 2020 Category: Cardiology Authors: Hajra A, Bandyopadhyay D Tags: Am J Hypertens Source Type: research

Response to COVID-19 and ACEI/ARB: NOT ASSOCIATED?
PMID: 32415836 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - May 16, 2020 Category: Cardiology Authors: Schiffrin EL, Flack JM, Ito S, Muntner P, Webb RC Tags: Am J Hypertens Source Type: research

Relationship of socioeconomic status to arterial stiffness: comparison between medical aid beneficiaries and National Health Insurance beneficiaries.
This study was conducted to investigate the association between healthcare systems and arterial stiffness. METHODS: A total of 8929 subjects (60 years old and 55% were male) who underwent brachial-ankle pulse wave velocity (baPWV) measurement were retrospectively analyzed. There were 8237 National Health Insurance (NHI) beneficiaries (92.2%) and 692 medical aid (MA) beneficiaries (7.8%). The median value of baPWV was 1540 cm/s. RESULTS: Subjects with higher baPWV values (≥ 1540 cm/s) were older, and more frequently had cardiovascular risk factors and unfavorable laboratory findings than those with lower values baPWV (
Source: American Journal of Hypertension - May 11, 2020 Category: Cardiology Authors: Kim HL, Lee JY, Lim WH, Seo JB, Kim SH, Zo ZH, Kim MA Tags: Am J Hypertens Source Type: research

Sympathetic Activation in Hypertension: Importance of the Central Nervous System.
Abstract The sympathetic nervous system plays a critical role in the pathogenesis of hypertension. The central nervous system (CNS) organizes the sympathetic outflow and various inputs from the periphery. The brain renin-angiotensin system has been studied in various regions involved in controlling sympathetic outflow. Recent progress in cardiovascular research, particularly in vascular biology and neuroscience, as well as in traditional physiological approaches, has advanced the field of the neural control of hypertension in which the CNS plays a vital role. Cardiovascular research relating to hypertension has fo...
Source: American Journal of Hypertension - May 6, 2020 Category: Cardiology Authors: Hirooka Y Tags: Am J Hypertens Source Type: research

Association between cost-related medication nonadherence and hypertension management among US adults.
The objective of this study was to examine the association between cost-related medication nonadherence and self-reported antihypertensive medication use and self-reported normal blood pressure among US adults with self-reported hypertension. METHODS: Participants with self-reported hypertension from the 2017 National Health Interview Survey were included (n=7,498). Cost-related medication nonadherence was defined using standard questions. Hypertension management included: 1) self-reported current antihypertensive medication use, and 2) self-reported normal blood pressure within the past 12 months. Adjusted prevalence...
Source: American Journal of Hypertension - May 5, 2020 Category: Cardiology Authors: Fang J, Chang T, Wang G, Loustalot F Tags: Am J Hypertens Source Type: research

Empagliflozin for Patients with Presumed Resistant Hypertension: a Post Hoc Analysis of the EMPA-REG OUTCOME Trial.
Abstract BACKGROUND: Type 2 diabetes (T2D) and resistant hypertension (rHT) often coexist, greatly increasing risk of target-organ damage and death. We explored the effects of empagliflozin in patients with and without presumed resistant hypertension (prHT) in a post hoc analysis of EMPA-REG OUTCOME (NCT01131676). METHODS: Overall, 7020 patients received empagliflozin 10mg, 25mg, or placebo with median follow-up of 3.1 years. We defined baseline prHT as ≥3 classes of antihypertensive drugs including a diuretic and uncontrolled BP (SBP≥140 and/or diastolic BP [DBP]≥90 mmHg), or ≥4 classes of antihy...
Source: American Journal of Hypertension - May 5, 2020 Category: Cardiology Authors: Ferreira JP, Fitchett D, Ofstad AP, Kraus BJ, Wanner C, Zwiener I, Zinman B, Lauer S, George JT, Rossignol P, Zannad F Tags: Am J Hypertens Source Type: research

American Versus European Hypertension Guidelines: The Case of White Coat Hypertension.
Abstract BACKGROUND: The impact of the 2017 American College Cardiology/American Heart Association guidelines on reclassification of white coat hypertension (WCH) and white coat uncontrolled hypertension (WUCH) phenotypes has not been thoroughly investigated, so far. The aim of the present analysis was to compare the prevalence rates of WCH and WUCH according to either 2018 European Society Hypertension/European Society Cardiology and 2017 ACC/AHA hypertension guidelines. METHODS: A large database of individual 24-hour ambulatory blood pressure (BP) recordings from untreated and treated hypertensive individua...
Source: American Journal of Hypertension - April 29, 2020 Category: Cardiology Authors: Cuspidi C, Paoletti F, Tadic M, Sala C, Dell'Oro R, Grassi G, Mancia G Tags: Am J Hypertens Source Type: research

White Coat Hypertension-A Case for Assessing Vascular Age?
PMID: 32347902 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - April 29, 2020 Category: Cardiology Authors: Climie RE, Lambert EA, Schlaich MP, Lambert GW Tags: Am J Hypertens Source Type: research

Use of a Combination of Insulin Sensitizers and Antioxidant Supplements in the Management of Pregnancy Hypertensive Disorders.
PMID: 32337574 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - April 27, 2020 Category: Cardiology Authors: Arishe OO, Ebeigbe AB, Webb RC Tags: Am J Hypertens Source Type: research

Prevalence of Angiotensin II Type 1 Receptor Antibodies in Persons with Hypertension and Relation to Blood Pressure and Medication.
CONCLUSION: AT1RAb was prevalent among hypertensive adults and was associated with higher BP among persons on an ARB. PMID: 32330222 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - April 24, 2020 Category: Cardiology Authors: Philogene MC, Han D, Alvarado F, Fedarko NS, Zonderman AB, Evans MK, Crews DC Tags: Am J Hypertens Source Type: research

Associations of maternal early-pregnancy glucose concentrations with placental hemodynamics, blood pressure and gestational hypertensive disorders.
CONCLUSIONS: Maternal early-pregnancy non-fasting glucose concentrations within the normal range are associated with blood pressure in early pregnancy, but do not seem to affect placental hemodynamics and the risks of gestational hypertensive disorders. PMID: 32322887 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - April 23, 2020 Category: Cardiology Authors: Erkamp JS, Geurtsen ML, Duijts L, Reiss IKM, Mulders AGMGJ, Steegers EAP, Gaillard R, Jaddoe VWV Tags: Am J Hypertens Source Type: research

How to Manage Hypertension in People with Diabetes.
Abstract Hypertension is a common condition that is often seen in patients with diabetes. Both diseases increase the risk of morbidity and mortality from CV events and kidney disease progression. Factors that influence blood pressure control in diabetes include the persons' genetic background for hypertension and kidney disease, level of obesity and insulin resistance, the magnitude of pre-existing kidney disease, and lifestyle factors such as level of sodium and potassium intake, sleep quality and exercise effort all of which can affect levels of sympathetic nerve activity and contribute to increased blood pressu...
Source: American Journal of Hypertension - April 20, 2020 Category: Cardiology Authors: Ali W, Bakris GL Tags: Am J Hypertens Source Type: research

Hypertension Management in Emergency Departments.
Abstract Elevated blood pressure is pervasive among patients that visit emergency departments for their care. In this review article, we outline the current approach to the management of these individuals and highlight the crucial role emergency medicine clinicians play in reducing the morbidity associated with elevated blood pressure. We highlight the critical importance of immediate treatment when elevated blood pressure contributes to new or worsening end-organ injury but emphasize that such hypertensive emergencies are rare. For the vast majority of patients with elevated blood pressure in the emergency depart...
Source: American Journal of Hypertension - April 20, 2020 Category: Cardiology Authors: Miller J, McNaughton C, Joyce K, Binz S, Levy P Tags: Am J Hypertens Source Type: research

Resistant hypertension in a patient with chronic type B aortic dissection. A selective indication for renal artery denervation treatment.
PMID: 32307546 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - April 20, 2020 Category: Cardiology Authors: Trabattoni D, Galli S, Rogacka R, Teruzzi G, Montorsi P Tags: Am J Hypertens Source Type: research

Reserpine: A new consideration of an old drug for Hypertension?
PMID: 32303749 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - April 18, 2020 Category: Cardiology Authors: Weir MR Tags: Am J Hypertens Source Type: research