Assessment of Arterial Stiffness in Patients with Resistant Hypertension: Additional Insights into the Pathophysiology of this condition?
Abstract Good understanding of the pathophysiological mechanism(s) of resistant hypertension (RH) and the relationship to vascular dysfunction is important for optimal blood pressure control. The aim of this review article is to summarise the available data on the methods of arterial stiffness assessment, and their usefulness in RH. Several studies that provide information on the non-invasive methods of evaluation of arterial stiffness have been discussed; specifically, pulse wave velocity (PWV) and augmentation index (AIx) tests. Increased arterial stiffness, elevated AIx and impaired endothelial function all act...
Source: American Journal of Hypertension - October 14, 2019 Category: Cardiology Authors: Alsharari R, Lip GYH, Shantsila A Tags: Am J Hypertens Source Type: research

Two days ABPM-derived indices and mortality in hemodialysis patients.
CONCLUSIONS: These findings indicate a strong relationship between arterial stiffness and cardiovascular risk and support a wider use of 44-h ABPM recording for risk stratification in hemodialysis patients. PMID: 31605486 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - October 12, 2019 Category: Cardiology Authors: Viazzi F, Cappadona F, Leoncini G, Ratto E, Gonnella A, Bonino B, Verzola D, Garibotto G, Pontremoli R Tags: Am J Hypertens Source Type: research

More precise and unbiased blood pressure measures: automatic office blood pressure.
PMID: 31585461 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - October 5, 2019 Category: Cardiology Authors: Cheng HM, Chuang SY Tags: Am J Hypertens Source Type: research

High-Salt Intake Reduces Apomorphine-Induced Penile Erection and Increases Neurally Mediated Contractile Responses of the Cavernosal Smooth Muscle in Rats.
CONCLUSIONS: A high-salt diet alone rendered the animals less responsive to apomorphine-induced penile erection and enhanced neurally mediated contractile responses in the corpus cavernosum, a clear indication that overconsumption of sodium can lead to erectile dysfunction even without the development of hypertension. PMID: 31584631 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - October 4, 2019 Category: Cardiology Authors: Leitolis A, Crestani S, Linder ÁE, da Silva-Santos JE Tags: Am J Hypertens Source Type: research

miR-27a in extracellular vesicles - Is it a novel modulator of hypertension?
VA PMID: 31576410 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - October 2, 2019 Category: Cardiology Authors: Carlström M, Braga VA Tags: Am J Hypertens Source Type: research

The current status of devices for the treatment of resistant hypertension.
d F Abstract Arterial hypertension is associated with increased cardiovascular morbidity and mortality. Although blood pressure-lowering therapies significantly reduce the risk of major cardiovascular events, blood pressure control remains unsatisfactorily low. Several device-based antihypertensive therapies have been investigated in patients with treatment-resistant hypertension and in patients unable or unwilling to adhere to antihypertensive medication. As the field of device-based therapies is subject to constant change, this review aims at providing an up-to-date overview of different device-based approaches ...
Source: American Journal of Hypertension - October 1, 2019 Category: Cardiology Authors: Kunz M, Lauder L, Ewen S, Böhm M, Mahfoud F Tags: Am J Hypertens Source Type: research

Regular exercise participation contributes to better proteostasis, inflammatory and vasoactive profiles in patients with hypertension.
CONCLUSIONS: Individuals with regular exercise participation showed better proteostasis, quality of life, inflammatory profile, antioxidant defences, and eNOS levels. PMID: 31560738 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - September 27, 2019 Category: Cardiology Authors: Teixeira M, Gouveia M, Duarte A, Ferreira M, Simões MI, Conceição M, Silva G, Magalhães S, Ferreira R, Nunes A, Vieira SI, Ribeiro F Tags: Am J Hypertens Source Type: research

Role of blood pressure in mediating carotid artery dilation in response to sympathetic stimulation in healthy, middle-aged individuals.
CONCLUSION: Our data suggests that the characteristic increase in MAP during the CPT does not mediates carotid artery vasomotion. PMID: 31560753 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - September 27, 2019 Category: Cardiology Authors: Peace A, Pinna V, Timmen F, Speretta G, Jones H, Lotto R, Jones I, Thijssen D Tags: Am J Hypertens Source Type: research

Copeptin levels in patients with treatment resistant hypertension before and six months after renal denervation.
CONCLUSION: Patients with TRH showed 2 fold higher copeptin levels than patients with HT. RDN did not lead to any change of copeptin levels in patients with TRH 6 months after procedure despite significant fall in BP. PMID: 31555795 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - September 26, 2019 Category: Cardiology Authors: Bosch A, Schmid A, Ott C, Kannenkeril D, Karg M, Ditting T, Veelken R, Uder M, Schmieder RE Tags: Am J Hypertens Source Type: research

Hypertension and brachydactyly syndrome associated with vertebral artery malformation caused by a PDE3A missense mutation.
CONCLUSIONS: Genetic screening can significantly improve the diagnosis of HTNB patients at an early age. Our study not only adds to the spectrum of PDE3A mutations in the Chinese population and extends the phenotype of HTNB patients to include vertebral malformation but also improves the awareness of pathogenesis in HTNB patients. We emphasize the importance of antihypertensive treatment and long term follow-up to prevent stroke and adverse cardiovascular events. PMID: 31549136 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - September 24, 2019 Category: Cardiology Authors: Fan P, Zhang D, Yang KQ, Zhang QY, Luo F, Lou Y, Liu YX, Zhang HM, Song L, Cai J, Wu HY, Zhou XL Tags: Am J Hypertens Source Type: research

Erratum.
Authors: PMID: 31550042 [PubMed - in process] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - September 24, 2019 Category: Cardiology Tags: Am J Hypertens Source Type: research

Mechanotransduction and uterine blood flow in preeclampsia- The role of mechanosensing Piezo 1 ion channels.
Abstract There is a large increase in uterine arterial blood flow during normal pregnancy. Structural and cellular adjustments occur in the uterine vasculature during pregnancy to accommodate this increased blood flow through a complex adaptive process that is dependent on multiple coordinated and interactive influences and this process is known as 'vascular remodeling'. The etiology of preeclampsia involves aberrant placentation and vascular remodeling leading to reduced uteroplacental perfusion. The placental ischemia leads to development of hypertension and proteinuria in the mother, intrauterine growth restric...
Source: American Journal of Hypertension - September 23, 2019 Category: Cardiology Authors: Arishe OO, Ebeigbe AB, Webb RC Tags: Am J Hypertens Source Type: research

Genome wide association study of apparent treatment resistant hypertension in the CHARGE consortium: The CHARGE Pharmacogenetics Working Group.
aresan A, Lange L, Correa A, Stott DJ, Ford I, Jukema JW, Gudnason V, Mook-Kanamori DO, Trompet S, Palmas W, Warren HR, Hellwege JN, Giri A, O'Donnell C, Hung AM, Edwards TL, Ahluwalia TS, Arnett DK, Avery CL, VA Million Veteran Program and the CHARGE Pharmacogenetics Working group Abstract BACKGROUND: Only a handful of genetic discovery efforts in apparent treatment resistant hypertension (aTRH) have been described. METHODS: We conducted a case-control genome-wide association study (GWAS) of aTRH among persons treated for hypertension, using data from 10 cohorts of European ancestry (EA) and 5 cohorts of Afr...
Source: American Journal of Hypertension - September 23, 2019 Category: Cardiology Authors: Irvin MR, Sitlani CM, Floyd JS, Psaty BM, Bis JC, Wiggins KL, Whitsel EA, Sturmer T, Stewart J, Raffield L, Sun F, Liu CT, Xu H, Cupples AL, Tanner RM, Rossing P, Smith A, Zilhão NR, Launer LJ, Noordam R, Rotter JI, Yao J, Li X, Guo X, Limdi N, Sundaresa Tags: Am J Hypertens Source Type: research

Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitors Across the Spectrum of Hypertension.
Abstract Sodium glucose cotransporter 2 (SGLT2) inhibitors represent a novel class of oral antihyperglycemic drugs that have been approved over the last decade for the management of type 2 diabetes mellitus. Except the glucose lowering effects, robust evidence also suggests that SGLT2 inhibitors confer benefits in cardiovascular system. The purpose of this review was to investigate the effects of SGLT2 inhibitors across the spectrum of arterial hypertension. PMID: 31541572 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - September 21, 2019 Category: Cardiology Authors: Sanidas EA, Papadopoulos DP, Hatziagelaki E, Grassos C, Velliou M, Barbetseas J Tags: Am J Hypertens Source Type: research

Reducing Hypertension in a Post-Stroke Black and Hispanic Homecare Population: Results of a Pragmatic Randomized Controlled Trial.
CONCLUSION: The significant across-the-board SBP decreases suggest that UHC nurse/patient/physician interactions were the central component of SBP reduction and that additional efforts to lower recurrent stroke risk should test incremental improvements in usual care, not resource-intensive transitional care interventions. They also suggest the potential value of pragmatic homecare programs as part of a broader strategy to overcome HTN treatment barriers and improve secondary stroke prevention globally. PMID: 31541606 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - September 21, 2019 Category: Cardiology Authors: Feldman PH, McDonald MV, Trachtenberg M, Trifilio M, Onorato N, Sridharan S, Silver S, Eimicke J, Teresi J Tags: Am J Hypertens Source Type: research

Association between High FSH, Low Progesterone and Idiopathic Pulmonary Arterial Hypertension in Women of Reproductive Age.
CONCLUSIONS: In reproductive women with IPAH, high follicle stimulating hormone and low progesterone tended to be associated with high risk of IPAH and mortality among patients. PMID: 31504137 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - August 29, 2019 Category: Cardiology Authors: Zhang YX, Wang L, Lu WZ, Yuan P, Wu WH, Zhou YP, Zhao QH, Zhang SJ, Li Y, Wu T, Jiang X, Jing ZC Tags: Am J Hypertens Source Type: research

Heart-thigh cuff pulse wave velocity: Aiming for the best of both worlds?
PMID: 31504130 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - August 24, 2019 Category: Cardiology Authors: Yu S, McEniery CM Tags: Am J Hypertens Source Type: research

Is Central Blood Pressure a Determinant of Flow-Mediated Dilation in Patients With Coronary Artery Disease?
PMID: 31504128 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - August 23, 2019 Category: Cardiology Authors: Ghiadoni L, Bruno RM Tags: Am J Hypertens Source Type: research

Intracranial Atherosclerosis and Stage 1 Hypertension Defined by the 2017 ACC/AHA Guideline.
In this study, we evaluated the relationship between this newly defined stage 1 hypertension and the presence of intracranial atherosclerosis (ICAS) lesions in neurologically healthy participants. METHODS: We assessed consecutive participants in routine health check-ups between January 2006 and December 2013. BP was classified according to the 2017 ACC/AHA hypertension guideline, and ICAS was defined as occlusion or ≥ 50% stenosis of intracranial vessels on flight magnetic resonance angiography. RESULTS: Among 3,111 healthy participants (mean age: 56 years, sex: 54% men), 85 (3%) had ICAS lesions. In multivari...
Source: American Journal of Hypertension - August 21, 2019 Category: Cardiology Authors: Nam KW, Kwon HM, Jeong HY, Park JH, Kwon H, Jeong SM Tags: Am J Hypertens Source Type: research

Augmenting Renal Lymphatic Density Prevents Angiotensin II-Induced Hypertension in Male and Female Mice.
CONCLUSION: Renal lymphatics play a significant role in renal immune cell trafficking and blood pressure regulation, and represent a novel avenue of therapy for hypertension. PMID: 31429865 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - August 20, 2019 Category: Cardiology Authors: Balasubbramanian D, Lopez Gelston CA, Lopez AH, Iskander G, Tate W, Holderness H, Rutkowski JM, Mitchell BM Tags: Am J Hypertens Source Type: research

Complement components sC5b-9 and CH50 predict prognosis in heart failure patients combined with hypertension.
Abstract BACKGROUND: Heart failure (HF), resulting from inflammation and vessel injury, is one of the leading causes of poor quality of life and premature death. The complement system plays a leading role in vessel integrity and inflammation response. However, the association between serum complement level and the prognosis of HF remains unclear. METHODS: In our study, a total of 263 newly diagnosed hypertension patients with HF were included. Eight classical Cardiovascular(CV) risk factors were collected, and plasma C3a, C3b, C5a, sC5b-9, and CH50 levels were detected. RESULTS: Compared with control group, plasma C5a(p
Source: American Journal of Hypertension - August 20, 2019 Category: Cardiology Authors: Wang W, Cai D Tags: Am J Hypertens Source Type: research

Determinants of increased central excess pressure in dialysis: role of dialysis modality and arteriovenous fistula.
CONCLUSION: This study suggests that higher XSPI in HD patients is related to the presence of AVF. PMID: 31419806 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - August 17, 2019 Category: Cardiology Authors: Paré M, Goupil R, Fortier C, Mac-Way F, Madore F, Marquis K, Hametner B, Wassertheurer S, Schultz MG, Sharman JE, Agharazii M Tags: Am J Hypertens Source Type: research

Circadian blood pressure variations computed from 1.7 million measurements in an acute hospital setting.
CONCLUSION: Hospitalised patients' circadian patterns of BP largely mirror those found in the community. High-quality hospital data may allow for identification of patients at significant cardiovascular risk through either opportunistic or systematic screening. PMID: 31418774 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - August 16, 2019 Category: Cardiology Authors: Mahdi A, Watkinson P, McManus RJ, Tarassenko L Tags: Am J Hypertens Source Type: research

Association of Rising Violent Crime with Blood Pressure and Cardiovascular Risk: Longitudinal Evidence from Chicago, 2014-2016.
CONCLUSION: Rising violent crime was associated with increased BP during a temporal crime surge. PMID: 31414132 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - August 15, 2019 Category: Cardiology Authors: Tung EL, Besser SA, Chua RFM, Lindau ST, Kolak M, Anyanwu E, Liao JK, Tabit CE Tags: Am J Hypertens Source Type: research

A novel mutation in the glucocorticoid receptor gene causing resistant hypertension: a case report.
PMID: 31414133 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - August 15, 2019 Category: Cardiology Authors: Lin L, Wu X, Hou YM, Zheng F, Xu R Tags: Am J Hypertens Source Type: research

Hemodynamic Stress, Pulse Pressure, and Blood Pressure Variability may be Strong Triggers of Cardiovascular Events in Diabetes.
PMID: 31407770 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - August 13, 2019 Category: Cardiology Authors: Narita K, Hoshide S, Kario K Tags: Am J Hypertens Source Type: research

Association of sleep duration and blood pressure in adolescents: a multicenter study.
This study is part of the Study of Cardiovascular Risk in Adolescents (ERICA), a multicenter, school-based, cross-sectional study in 273 municipalities in Brazil. The sample consisted of 65,643 adolescents. Sleep duration was measured by a subjective method, and BP was measured by the oscillometric method. Multiple linear regression analyses were performed to evaluate the association between sleep duration and BP. RESULTS: The mean sleep duration was 8.14 hours (± 1.40), with significant difference between the groups according to blood pressure levels (p
Source: American Journal of Hypertension - August 13, 2019 Category: Cardiology Authors: Santos ESG, Souza OF Tags: Am J Hypertens Source Type: research

Voluntary Wheel Running Attenuates Salt-Induced Vascular Stiffness Independent of Blood Pressure.
Abstract BACKGROUND: Excess dietary salt can lead to the development of arterial stiffness and high blood pressure (BP). Regular physical activity can protect against arterial stiffening and lower BP. Less is known regarding the role of exercise on the vasculature independent of BP under high salt conditions. The aim of the study was to determine if wheel running protects against the development of dietary salt-induced arterial stiffness independent of BP. METHODS: Rats were maintained on either normal salt (NS; 0.49%NaCl) or high salt (HS; 4.0%NaCl) diet for 6 weeks and further divided into a voluntary wheel...
Source: American Journal of Hypertension - August 11, 2019 Category: Cardiology Authors: Guers JJ, Farquhar WB, Edwards DG, Lennon SL Tags: Am J Hypertens Source Type: research

Heterogenous treatment response by race cannot be claimed in the absence of evidence.
PMID: 31374115 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - August 2, 2019 Category: Cardiology Authors: Merckx J, Kaufman JS Tags: Am J Hypertens Source Type: research

Fasting blood glucose predicts incidence of hypertension independent of HbA1c levels and insulin resistance in middle-aged Japanese: The Saku study.
This study aimed to investigate the association between indices of diabetes and the incidence of hypertension and compare the predictive powers of these indices in middle-aged Japanese. METHODS: This 5-year cohort study included 2210 Japanese aged 30-64 years without hypertension. Hazard ratios of high fasting blood glucose (FBG) levels, high post-loaded BG levels, high glycated haemoglobin (HbA1c) levels, insulin resistance (defined by homeostasis model assessment of insulin resistance [HOMA-IR]) and impaired insulin secretion at baseline for the incidence of hypertension were estimated using multivariable-adjusted C...
Source: American Journal of Hypertension - August 1, 2019 Category: Cardiology Authors: Tatsumi Y, Morimoto A, Asayama K, Sonoda N, Miyamatsu N, Ohno Y, Miyamoto Y, Izawa S, Ohkubo T Tags: Am J Hypertens Source Type: research

New-onset resistant hypertension in a newly diagnosed prostate cancer patient.
We report the case of a 69-year-old man who developed severe resistant hypertension despite the use of 6 antihypertensive medications, including diuretics. He had metabolic alkalosis and hypokalemia with suppressed plasma renin activity and serum aldosterone. Concurrently, he was diagnosed with small cell neuroendocrine carcinoma of the prostate gland, a rare form of prostate cancer. Despite absence of typical Cushingoid features, investigation confirmed the diagnosis of ectopic ACTH syndrome (EAS) from neuroendocrine prostate cancer. Due to the severity of his hypercortisolism, he underwent urgent bilateral adrenalectomy ...
Source: American Journal of Hypertension - July 29, 2019 Category: Cardiology Authors: Klomjit N, Rowan DJ, Kattah AG, Bancos I, Taler SJ Tags: Am J Hypertens Source Type: research

Heart-Thigh Cuff Pulse Wave Velocity: A Novel Nontechnical Measure of Arterial Stiffness.
Abstract BACKGROUND: Recently, a novel index of arterial stiffness was developed to eliminate the placements of transducers on the carotid and femoral arteries and to make the measurement substantially easier. We evaluated the agreement of this new methodology with the well-established carotid-femoral pulse wave velocity (cfPWV). METHODS: A total of 50 adults (28 men and 22 women) varying widely in age and blood pressure were studied. Heart-thigh PWV (htPWV) and cfPWV were measured and compared. RESULTS: Mean values of cfPWV and htPWV were 713±145 cm/sec and 699±150 cm/sec and were not sign...
Source: American Journal of Hypertension - July 29, 2019 Category: Cardiology Authors: Fico BG, Gourley DD, Wooten SV, Tanaka H Tags: Am J Hypertens Source Type: research

Endothelial microvesicles circulating in peripheral and coronary circulation are associated with central blood pressure in coronary artery disease.
CONCLUSIONS: EMVs emerge as novel markers of ongoing underlying vascular damage, further augmenting the vicious cycle of inflammation and thrombosis mainly in ACS but also in stable CAD. PMID: 31350539 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - July 27, 2019 Category: Cardiology Authors: Gkaliagkousi E, Gavriilaki E, Vasileiadis I, Nikolaidou B, Yiannaki E, Lazaridis A, Triantafyllou A, Anyfanti P, Markala D, Zarifis I, Douma S Tags: Am J Hypertens Source Type: research

Acute Blood Pressure and Cardiovascular Effects of Near-Roadway Exposures with and without N95-Respirators.
Abstract BACKGROUND: The risk for cardiovascular events increases within hours of near-roadway exposures. We aimed to determine the traffic-related air pollutants (TRAP) and biological mechanisms involved and if reducing particulate matter
Source: American Journal of Hypertension - July 27, 2019 Category: Cardiology Authors: Morishita M, Wang L, Speth K, Zhou N, Bard RL, Li F, Brook JR, Rajagopalan S, Brook RD Tags: Am J Hypertens Source Type: research

Impact of Clinic-Based Blood Pressure Approaches on Blood Pressure Measurement.
Abstract BACKGROUND: Clinic-based blood pressure (BP) is a closely-tracked metric of healthcare quality, but is prone to inaccuracy and measurement imprecision. Recent guidelines have advocated for automatic office-based BP (AOBP) devices to improve clinic-based BP assessments. METHODS: Patients from a single hypertension clinic underwent a 3-day evaluation that included a 24-hour ambulatory BP monitor (ABPM), two manual clinic-based BP measurements (over two visits), and an unattended AOBP measurement (single visit). All measurements were compared to the average wake-time systolic BP (SBP) and diastolic BP (...
Source: American Journal of Hypertension - July 27, 2019 Category: Cardiology Authors: Juraschek SP, Ishak A, Mukamal KJ, Cohen ML, Beach JL Tags: Am J Hypertens Source Type: research

Circulating Plasma Metabolomic Profiles Differentiate Rodent Models of Pulmonary Hypertension and Idiopathic Pulmonary Arterial Hypertension Patients.
CONCLUSIONS: These two models may develop PAH through different metabolomic pathways and each of the two classical PH model resembles IPAH patients in certain aspects. PMID: 31350549 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - July 27, 2019 Category: Cardiology Authors: Zhao JH, He YY, Guo SS, Yan Y, Wang Z, Ye J, Zhang JL, Wang Y, Pang XB, Xie XM, Lin JH, Jing ZC, Han ZY Tags: Am J Hypertens Source Type: research

Blood Pressure Screening Campaign in Jamaica: May Measurement Month 2017.
Abstract BACKGROUND: Hypertension is responsible for a significant disease burden in Jamaica. We are reporting the results of the 2017 blood pressure (BP) screening campaign May Measurement Month in Jamaica that aimed to increase the awareness of hypertension. METHODS: Adults, 18 years old and older, from different parishes of Jamaica were invited to participate during May-June 2017. Demographic data were collected. BP, weight and height were measured and recorded. RESULTS: Five hundred and sixty six participants (n=566) were enrolled, 91.6% (519) from urban areas, and 72.6% (410) were females. The avera...
Source: American Journal of Hypertension - July 27, 2019 Category: Cardiology Authors: Nwokocha M, Romero CA, Holder C, Whylie N, Wong H, Lietch J, Wilks R, Hosang M, Francis S, Brown PD, Paul T, Abel W, Barton E, Wilks R, Nwokocha C Tags: Am J Hypertens Source Type: research

Response to "The effect of arteriovenous fistula (AVF) on hard endpoints should be observed prospectively in both CKD and non-CKD patients".
Response to "The effect of arteriovenous fistula (AVF) on hard endpoints should be observed prospectively in both CKD and non-CKD patients". Am J Hypertens. 2019 Jul 26;: Authors: Mathew RO, Fleg J, Rangaswami J, Cai B, Asif A, Sidhu MS, Bangalore S PMID: 31346596 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - July 26, 2019 Category: Cardiology Authors: Mathew RO, Fleg J, Rangaswami J, Cai B, Asif A, Sidhu MS, Bangalore S Tags: Am J Hypertens Source Type: research

Secreted Monocyte miR-27a, via Mesenteric Arterial Mas Receptor-eNOS Pathway, Causes Hypertension.
CONCLUSIONS: Monocyte miR-27a in EVs decreases Mas receptor expression and eNOS phosphorylation in endothelium, impairs Ang-(1-7)-mediated vasodilation and causes hypertension. Understanding the contributions of EVs in the pathogenesis of hypertension may facilitate their use as a diagnostic biomarker. PMID: 31328772 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - July 22, 2019 Category: Cardiology Authors: Zou X, Wang J, Chen C, Tan X, Huang Y, Jose PA, Yang J, Zeng C Tags: Am J Hypertens Source Type: research

The ACC/AHA and ESC/ESH Hypertension Guidelines: Contrasting Versions of Idiosyncratic Excellence.
PMID: 31314900 [PubMed - in process] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - July 17, 2019 Category: Cardiology Authors: Flack JM, Calhoun D Tags: Am J Hypertens Source Type: research

New Coverage Schemes in Health, Income Level, Costs, and Use of Services in the Management of Hypertension.
PMID: 31310272 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - July 16, 2019 Category: Cardiology Authors: Arredondo A, Recaman AL Tags: Am J Hypertens Source Type: research

Angiotensin 1-7 and the Sympathetic Nervous System in Hypertensive Kidney Disease.
PMID: 31310274 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - July 15, 2019 Category: Cardiology Authors: Tsuda K Tags: Am J Hypertens Source Type: research

Clinical Course, Management, and Outcomes of Pediatric Takayasu Arteritis Initially Presenting with Hypertension: a 16-year overview.
This study retrospectively reviewed medical charts of 96 inpatient c-TA cases from 2002/01 to 2016/12, with 5 additional patients being prospectively recruited from 2017/01 to 2017/12. Data were compared between c-TA groups initially presenting with and without hypertension. Blood pressure(BP) control, event-free survival, and associated risk factors were assessed by logistic regression, Kaplan-Meier survival curve, and COX regression models. RESULTS: The hypertensive cohort(n=71, 28.2% males) as compared with non-hypertensive cohort had significantly fewer active diseases; fewer episodes of claudication, syncope, blu...
Source: American Journal of Hypertension - July 5, 2019 Category: Cardiology Authors: Fan L, Zhang H, Cai J, Yang L, Wei D, Yu J, Fan J, Song L, Ma W, Lou Y Tags: Am J Hypertens Source Type: research

H2FPEF Score as a Prognostic Value in HFpEF patients.
This study was a retrospective, single-center, observational study. We calculated the H2FPEF scores for 404 consecutive HFpEF patients. Subjects were subdivided into low- (0-3), intermediate- (4-6), and high-score (7-9) groups and followed for 50-months. The primary and secondary endpoints were composite cardiovascular/ cerebrovascular events (cardiovascular death, non-fatal myocardial infarction, unstable angina pectoris, hospitalization for HF decompensation and non-fatal stroke) occurrence and HF-related events (hospitalization for HF decompensation) occurrence at 50-months, respectively. RESULTS: Kaplan-Meier anal...
Source: American Journal of Hypertension - July 4, 2019 Category: Cardiology Authors: Sueta D, Yamamoto E, Nishihara T, Tokitsu T, Fujisue K, Oike F, Takae M, Usuku H, Takashio S, Arima Y, Suzuki S, Nakamura T, Ito M, Kanazawa H, Sakamoto K, Kaikita K, Tsujita K Tags: Am J Hypertens Source Type: research

Prenatal alcohol exposure and the associated risk of elevated blood pressure: A cross-sectional analysis of 3 to 17-year- olds in Germany.
CONCLUSIONS: Contrary to our initial hypothesis, PAE reduces the risk of pre-hypertension. Animal studies suggest that vasodilation is induced by nitric oxide in small quantities of PAE. PMID: 31269195 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - July 3, 2019 Category: Cardiology Authors: Arnold C, Ullrich C, Wensing M, Pfinder M Tags: Am J Hypertens Source Type: research

Influence of prediabetes on the effects of intensive systolic blood pressure control on kidney events.
We examined whether prediabetes modified the effects of intensive SBP lowering on the incidence of chronic kidney disease (CKD) and acute kidney injury (AKI) events in a post-hoc analysis of the Systolic Blood Pressure Intervention Trial (SPRINT). Diabetes was a SPRINT exclusion criterion. We defined normoglycemia and prediabetes as fasting plasma glucose
Source: American Journal of Hypertension - June 29, 2019 Category: Cardiology Authors: Rathi N, Whelton PK, Chertow GM, Cushman WC, Cheung AK, Wei G, Boucher R, Kimmel PL, Bress A, Kramer HJ, Al-Marji C, Greene T, Beddhu S Tags: Am J Hypertens Source Type: research

Sex and body mass index modify the association between leptin and sodium excretion: a cross-sectional study in an African population.
Abstract BACKGROUND: Renal sodium handling could be a potential mediator linking adipokines to hypertension. The aim of the study was to assess the relationship of leptin with urinary sodium excretion and proximal sodium reabsorption in humans. METHODS: This crossectional study was conducted on participants of hypertensive families from the Seychelles Island. A split urine (daytime and nighttime) collection and plasma leptin were measured. Endogenous lithium clearance was used to assess proximal sodium reabsorption. Mixed multiple linear regression tests adjusted for confounding factors were used. RESULT...
Source: American Journal of Hypertension - June 29, 2019 Category: Cardiology Authors: Schwotzer N, Burnier M, Maillard M, Bovet P, Paccaud F, Bochud M, Wuerzner G Tags: Am J Hypertens Source Type: research

24-hour vs Spot Urinary Sodium and Potassium Measurements in Adult Hypertensive patients; A Cohort Validation Study.
We examined 419 hypertensive patients from the UCL Complex Hypertension Clinic. 77 had matched and complete 24-hour and spot urinary and serum biochemistry to examine. RESULTS: Our cohort was 58% male and the median age was 41 years. The 24-hour and spot Na concentrations correlated moderately (r=0.4633, p
Source: American Journal of Hypertension - June 27, 2019 Category: Cardiology Authors: Wan ER, Cross J, Sofat R, Walsh SB Tags: Am J Hypertens Source Type: research

Association between intra-arterial invasive central and peripheral blood pressure and endothelial function (assessed by flow-mediated dilatation) in stable coronary artery disease.
Abstract BACKGROUND: Endothelial function is an independent predictor of coronary artery disease (CAD) and is regulated by a number of factors, including blood pressure. OBJECTIVES: The current study was designed to test the hypothesis that intra-arterial invasive central blood pressure is strongly associated with endothelial function in patients with CAD. METHODS: In patient with CAD (diameter stenosis ≥30%), invasive central (aortic) and left peripheral (brachial) blood pressures were determined during transradial coronary angiography. The endothelial function was evaluated by way of flow-mediated d...
Source: American Journal of Hypertension - June 22, 2019 Category: Cardiology Authors: Park KH, Park WJ, Han SJ, Kim HS, Jo SH, Kim SA, Suh SW Tags: Am J Hypertens Source Type: research

Trends in Blood Pressure and High-Sensitivity Cardiac Troponin-T with Cardiovascular Disease: The Cardiovascular Health Study.
Abstract BACKGROUND: High-sensitivity cardiac troponin T (hs-cTnT) is individually associated with incident hypertension (HTN) and cardiovascular disease (CVD) events. We hypothesize that the increases in hs-cTnT with increases in blood pressure will be related to higher incidence of CVD. METHODS: The Cardiovascular Health Study is a longitudinal cohort of older adults. Those with hs-cTnT data and CVD risk factors at baseline and follow-up (2-3 years later) were stratified based on systolic blood pressure (SBP) (optimal:
Source: American Journal of Hypertension - June 21, 2019 Category: Cardiology Authors: Tehrani DM, Fan W, Nambi V, Gardin J, Hirsch CH, Amsterdam E, deFilippi CR, Polonsky T, Wong ND Tags: Am J Hypertens Source Type: research