Associations between Social Determinants and Hypertension, Stage 2 Hypertension and Controlled Blood Pressure among Men and Women in the US.
Abstract BACKGROUND: Social determinants influence the development and control of hypertension. METHODS: National Health and Nutrition Examination Survey (2011-2018) data for adults aged ≥18 included education, income, employment, race/ethnicity, healthcare access, marital status, and nativity status. Outcomes were hypertension (blood pressure (BP) ≥130/80 mm Hg or self-reported hypertension medication use), stage 2 hypertension (BP ≥140/90 mm Hg), and controlled BP (BP
Source: American Journal of Hypertension - January 11, 2021 Category: Cardiology Authors: Commodore-Mensah Y, Turkson-Ocran RA, Foti K, Cooper LA, Himmelfarb CD Tags: Am J Hypertens Source Type: research

The Role of Mitochondrial Dysfunction in Preeclampsia: Causative Factor or Collateral Damage?
Abstract Preeclampsia, new onset hypertension in pregnancy, affects ~ 5 -10% of the world's population. Preeclampsia is the leading cause of morbidity and mortality for both the mother and fetus. As of today, there is no cure for this disease except for delivery of the fetal-placental unit. The exact causation and onset of the disease is unknown. However, recent studies have shown a strong correlation between mitochondrial dysfunction and preeclampsia. Circulating mitochondrial DNA, elevated reactive oxygen species, angiotensin II type-1 receptor agonistic autoantibodies (AT1-AA), activated natural killer cells, a...
Source: American Journal of Hypertension - January 8, 2021 Category: Cardiology Authors: Smith AN, Wang X, Thomas DG, Tatum RE, Booz GW, Cunningham MW Tags: Am J Hypertens Source Type: research

Masked Nocturnal Hypertension:A Complex Phenomenon to Detect in Clinical Practice.
PMID: 33417669 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - January 8, 2021 Category: Cardiology Authors: Angeli F, Reboldi G, Verdecchia P Tags: Am J Hypertens Source Type: research

Genes, genetic polymorphism, diet, soluble mediators, and their role in the pathobiology of type 2 diabetes mellitus and hypertension.
PMID: 33417678 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - January 8, 2021 Category: Cardiology Authors: Das UN Tags: Am J Hypertens Source Type: research

High systolic blood pressure at hospital admission is an important risk factor in models predicting outcome of COVID-19 patients.
CONCLUSIONS: Using an unbiased approach, we developed models predicting outcome of COVID-19 patients based on data available at hospital admission. This can contribute to evidence-based risk prediction and appropriate decision-making at hospital triage to provide the most appropriate care and ensure the best patient outcome. High SBP, a cause of end-organ damage and an important comorbid factor, was identified as a covariate in both mortality and survival prediction models. PMID: 33386395 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - January 2, 2021 Category: Cardiology Authors: Caillon A, Zhao K, Klein KO, Greenwood C, Lu Z, Paradis P, Schiffrin EL Tags: Am J Hypertens Source Type: research

SARS-COV-2 RECEPTOR ACE2 GENE is associated with hypertension and SEVERity of COVID 19: interaction with sex, obesity and SMOKING.
CONCLUSION: This is the first report that ACE2 variants are associated with earlier penetrance and more severe hypertension and with more severe outcomes of COVID-19 in obese smoking males. PMID: 33386398 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - January 2, 2021 Category: Cardiology Authors: Hamet P, Pausova Z, Attaoua R, Hishmih C, Haloui M, Shin J, Paus T, Abrhamowicz M, Gaudet D, Santucci L, Kotchen TA, Cowley AW, Hussin J, Tremblay J Tags: Am J Hypertens Source Type: research

N-Terminal Pro-B-Type Natriuretic Peptide and Longitudinal Risk of Hypertension.
CONCLUSIONS: NT-proBNP was not associated with incident hypertension; this did not differ by race or sex. Cross-sectional associations of natriuretic peptides with hypertension are likely due to myocardial stretch due to increased afterload. PMID: 33378421 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - December 30, 2020 Category: Cardiology Authors: Nicoli CD, Plante TB, Long DL, Judd SE, McClure LA, Arora P, Cushman M Tags: Am J Hypertens Source Type: research

Angiotensin II and Amyloid- β Synergistically Induce Brain Vascular Smooth Muscle Cell Senescence.
CONCLUSIONS: Ang II and Aβ synergistically promoted BVSMC senescence at least due to enhancement of the p-ERK-p16-pRb signaling pathway, oxidative stress and NF-κB/IκB activity. PMID: 33349854 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - December 22, 2020 Category: Cardiology Authors: Bai HY, Min LJ, Shan BS, Iwanami J, Kan-No H, Kanagawa M, Mogi M, Horiuchi M Tags: Am J Hypertens Source Type: research

Hypertension in chronic kidney disease (CKD): diagnosis, classification and therapeutic targets.
Abstract Blood pressure (BP) in the office is often recorded without standardization of the technique of measurement. When office BP measurement is performed with a research-grade methodology, it can inform better therapeutic decisions. The reference-standard method of ambulatory BP monitoring together with the assessment of BP in the office enables the identification of white-coat and masked hypertension, facilitating the stratification of cardiorenal risk. Compared with general population, the prevalence of resistant hypertension is 2- to 3-fold higher among patients with chronic kidney disease (CKD). The use of...
Source: American Journal of Hypertension - December 17, 2020 Category: Cardiology Authors: Georgianos PI, Agarwal R Tags: Am J Hypertens Source Type: research

C-reactive protein and hypertension incidence in black and white Americans: REasons for Geographic And Racial Differences in Stroke (REGARDS) study.
CONCLUSIONS: Elevated CRP attenuated a portion of the unadjusted excess risk of hypertension in black adults, but this excess risk was attenuated when controlling for measures of obesity in females and diet and socioeconomic factors in males. Inflammation related to these risk factors might explain part of the black-white disparity in hypertension. PMID: 33326556 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - December 16, 2020 Category: Cardiology Authors: Plante TB, Long DL, Guo B, Howard G, Carson AP, Howard VJ, Judd SE, Jenny NS, Zakai NA, Cushman M Tags: Am J Hypertens Source Type: research

The perils of automated wrist-cuff devices and dental chairs in opportunistic blood pressure screening.
PMID: 33326575 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - December 16, 2020 Category: Cardiology Authors: Elias MF, Goodell AL, Davey A Tags: Am J Hypertens Source Type: research

Response to "ACE-2 downregulation and incidence of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection".
Response to "ACE-2 downregulation and incidence of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection". Am J Hypertens. 2020 Dec 15;: Authors: Dublin S, Walker R, Floyd JS, Shortreed SM, Fuller S, Albertson-Junkans L, Harrington LB, Greenwood-Hickman MA, Green BB, Psaty BM PMID: 33320177 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - December 15, 2020 Category: Cardiology Authors: Dublin S, Walker R, Floyd JS, Shortreed SM, Fuller S, Albertson-Junkans L, Harrington LB, Greenwood-Hickman MA, Green BB, Psaty BM Tags: Am J Hypertens Source Type: research

Prevalence and Determinants of Masked Hypertension in Nigeria: The REMAH Study.
Abstract BACKGROUND: Estimating the burden of hypertension in Nigeria hitherto relied on clinic blood pressure (BP) measurement alone. This excludes individuals with masked hypertension (MH) i.e. normotensive clinic but hypertensive out-of-clinic BP. METHOD: In a nationally representative sample of adult Nigerians, we obtained clinic BP using auscultatory method and out-of-clinic BP by self-measured home BP with semi-automated oscillometric device. Clinic BP was average of 5 consecutive measurements and home BP was average of 3 days duplicate morning and evening readings. MH was clinic BP
Source: American Journal of Hypertension - December 14, 2020 Category: Cardiology Authors: Odili AN, Danladi B, Chori BS, Oshaju H, Nwakile PC, Okoye IC, Abdullahi U, Nwegbu MM, Zawaya K, Essien I, Sada K, Ogedengbe JO, Aje A, Isiguzo GC Tags: Am J Hypertens Source Type: research

Paradoxical increase of 24-hour urinary aldosterone levels in obese patients with resistant hypertension on a high salt diet.
In this study, 1572 individuals with complete 24 h urine collections were analyzed. Mean BMI was 32.5±7.1 kg/m 2 and ranged from 24.6±2.4 kg/m 2 (1st quartile) to 41.0±4.2 kg/m2 (4th quartile). BMI was positively associated with 24h UNa and UAldo levels (p
Source: American Journal of Hypertension - December 8, 2020 Category: Cardiology Authors: Dudenbostel T, Li P, Calhoun DA Tags: Am J Hypertens Source Type: research

Renovascular hypertension induces myocardial mitochondrial damage, contributing to cardiac injury and dysfunction in pigs with metabolic syndrome.
CONCLUSIONS: Superimposition of MetS on swine RVH induces myocardial mitochondrial damage and dysfunction. MetS+RVH failed to activate mitophagy, resulting in greater cardiac remodeling, fibrosis, and diastolic dysfunction. Mitochondrial injury and impaired mitophagy may constitute important mechanisms and potential therapeutic targets to ameliorate cardiac damage and dysfunction in patients with coexisting MetS and RVH. PMID: 33277650 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - December 5, 2020 Category: Cardiology Authors: Aghajani Nargesi A, Farah MC, Zhu XY, Zhang L, Tang H, Jordan KL, Saadiq IM, Lerman A, Lerman LO, Eirin A Tags: Am J Hypertens Source Type: research

Dapagliflozin does not affect short-term blood pressure variability in patients with type-2 diabetes mellitus.
CONCLUSIONS: This study is the first to evaluate the effects of an SGLT-2 inhibitor on short-term BPV in patients with T2DM, showing no effect on dapagliflozin on all BPV indexes studied. PMID: 33277990 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - December 5, 2020 Category: Cardiology Authors: Papadopoulou E, Theodorakopoulou MP, Loutradis C, Tzanis G, Tzatzagou G, Kotsa K, Zografou I, Tsapas A, Karagiannis A, Sarafidis P Tags: Am J Hypertens Source Type: research

Changes in hypertension control in a community-based population of older adults, 2011-2013 to 2016-2017.
Abstract BACKGROUND: The 2014 hypertension guideline raised treatment goals in older adults. The study objective was to examine changes in blood pressure (BP) control (
Source: American Journal of Hypertension - December 5, 2020 Category: Cardiology Authors: Foti K, Matsushita K, Koton S, Walker KA, Coresh J, Appel LJ, Selvin E Tags: Am J Hypertens Source Type: research

Genome-wide and candidate gene association analyses identify a 14-SNPs combination for hypertension in patients with type 2 diabetes.
This study included 999 T2D (cohort 1) patients for the first genome scan stage and 922 T2D (cohort 2) patients for the replication stage. Here, we investigated the genetic susceptibility and cumulative weighted genetic risk score for hypertension in T2D patients of Han Chinese descent in Taiwan. RESULTS: Thirty novel genetic single nucleotide polymorphisms (SNPs) were associated with hypertension in T2D after adjusting for age and body mass index (p-value
Source: American Journal of Hypertension - December 4, 2020 Category: Cardiology Authors: Cheng CF, Hsieh AR, Liang WM, Chen CC, Chen CH, Wu JY, Lin TH, Liao CC, Huang SM, Huang YC, Ban B, Lin YJ, Tsai FJ Tags: Am J Hypertens Source Type: research

Circadian variation and arterial stiffness in chronic kidney disease and their treatment.
PMID: 33252663 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - November 30, 2020 Category: Cardiology Authors: Hoshide S, Suzuki D, Kario K Tags: Am J Hypertens Source Type: research

Mechanisms of Vascular Remodeling in Hypertension.
Abstract Hypertension is both a cause and a consequence of central artery stiffening, which in turn is an initiator and indicator of myriad disease conditions and thus all-cause mortality. Such stiffening results from a remodeling of the arterial wall that is driven by mechanical stimuli and mediated by inflammatory signals, which together lead to differential gene expression and concomitant changes in extracellular matrix composition and organization. This review focuses on biomechanical mechanisms by which central arteries remodel in hypertension within the context of homeostasis - what promotes it, what prevent...
Source: American Journal of Hypertension - November 27, 2020 Category: Cardiology Authors: Humphrey JD Tags: Am J Hypertens Source Type: research

Long term habitual vigorous physical activity is associated with lower visit-to-visit systolic blood pressure variability.
Abstract OBJECTIVE: Our work aimed to investigate the association between vigorous physical activity and visit-to-visit systolic blood pressure variability (BPV). METHODS: We conducted a post hoc analysis of SPRINT (Systolic Blood Pressure Intervention Trial), a well-characterized cohort of participants randomized to intensive (
Source: American Journal of Hypertension - November 27, 2020 Category: Cardiology Authors: Xu X, Meng X, Oka SI Tags: Am J Hypertens Source Type: research

Seasonal Variation in Masked Nocturnal Hypertension: The J-HOP Nocturnal Blood Pressure Study.
In this study, 2544 outpatients (mean age 63 years; hypertensives 92%) with cardiovascular risks underwent morning, evening and nighttime home BP measurements (measured at 2:00, 3:00, and 4:00 AM) using validated, automatic and oscillometric home BP devices. RESULTS: Our analysis showed that nighttime home systolic BP (SBP) was higher in summer than in other seasons (summer, 123.3±14.6 mmHg vs. spring, 120.7±14.8 mmHg; autumn, 121.1±14.8 mmHg; winter, 119.3±14.0 mmHg; all p
Source: American Journal of Hypertension - November 27, 2020 Category: Cardiology Authors: Narita K, Hoshide S, Kanegae H, Kario K Tags: Am J Hypertens Source Type: research

Digit Preference in Office Blood Pressure Measurements, United States 2015-2019.
The objective was to evaluate national trends in terminal digit preference in office BP measurements among adults with treated hypertension. METHODS: Data were from IQVIA's National Disease and Therapeutic Index, a nationally representative, serial cross-sectional survey of office-based physicians. The analysis included office visits from 2015 to 2019 among adults aged ≥18 years receiving antihypertensive treatment. Annual trends were examined in the percent of systolic and diastolic BP measurements ending in zero by patient sex, age, and race/ethnicity, physician specialty, and first or subsequent hypertension tre...
Source: American Journal of Hypertension - November 27, 2020 Category: Cardiology Authors: Foti KE, Appel LJ, Matsushita K, Coresh J, Alexander GC, Selvin E Tags: Am J Hypertens Source Type: research

Hypertensive Urgency: An Emergency Department Pipeline to Primary Care Pilot Study.
CONCLUSIONS: In this pilot study, coordinated referral between the ED and primary care provides safe, timely care for this high ASCVD risk population and leads to sustained reductions in BP and ED utilization. PMID: 33216142 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - November 20, 2020 Category: Cardiology Authors: Giaimo AA, Kang AJ, Huot SJ Tags: Am J Hypertens Source Type: research

Cardiovascular Benefits of Angiotensin Converting Enzyme Inhibition plus Calcium Channel Blockade in Patients Achieving Tight Blood Pressure Control and with Resistant Hypertension.
ors Abstract BACKGROUND: The 2017 hypertension guidelines lowered systolic blood pressure goals to
Source: American Journal of Hypertension - November 20, 2020 Category: Cardiology Authors: Brook RD, Kaciroti N, Bakris G, Dahlöf B, Pitt B, Velazquez E, Weber MA, Jamerson KA, ACCOMPLISH investigators Tags: Am J Hypertens Source Type: research

ACE-2 downregulation and incidence of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection.
PMID: 33206164 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - November 18, 2020 Category: Cardiology Authors: Weir RAP, Glen C, McDowell K Tags: Am J Hypertens Source Type: research

Urinary Sodium and Potassium, and Risk of Ischaemic and Haemorrhagic Stroke (INTERSTROKE): a case-control study.
a N, Weimar C, Diaz R, Yusoff K, Yusufali A, Oguz A, Wang X, Lanas F, Ogah OS, Ogunniyi A, Iversen HK, Malaga G, Rumboldt Z, Oveisgharan S, Hussain FA, Yusuf S Abstract BACKGROUND: Although low sodium intake (3·5g/day) are proposed as public health interventions to reduce stroke risk, there is uncertainty about the benefit and feasibility of this combined recommendation on prevention of stroke and its subtypes. METHODS: We obtained random urine samples from 9,275 cases of acute first stroke and 9,726 matched controls (8,761 matched pairs for conditional analysis) from 27 countries and estimated the 24-...
Source: American Journal of Hypertension - November 17, 2020 Category: Cardiology Authors: Judge C, O'Donnell MJ, Hankey GJ, Rangarajan S, Chin SL, Rao-Melacini P, Ferguson J, Smyth A, Xavier D, Lisheng L, Zhang H, Lopez-Jaramillo P, Damasceno A, Langhorne P, Rosengren A, Dans AL, Elsayed A, Avezum A, Mondo C, Ryglewicz D, Czlonkowska A, Pogoso Tags: Am J Hypertens Source Type: research

Response to: How important is the assessment of soluble ACE-2 in COVID-19?
PMID: 33201224 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - November 17, 2020 Category: Cardiology Authors: Rieder M, Bode C, Duerschmied D, Lother A Tags: Am J Hypertens Source Type: research

Twenty-Five-Year Changes in Office and Ambulatory Blood Pressure: Results from the Coronary Artery Risk Development in Young Adults (CARDIA) Study.
Abstract BACKGROUND: Blood pressure (BP) measured in the office setting increases from early through later adulthood. However, it is unknown to what extent out-of-office BP derived via ambulatory BP monitoring (ABPM) increases over time, and which participant characteristics and risk factors might contribute to these increases. METHODS: We assessed 25-year change in office- and ABPM-derived BP across sex, race, diabetes mellitus (DM), and body mass index (BMI) subgroups in the Coronary Artery Risk Development in Young Adults study using multivariable-adjusted linear mixed effects models. RESULTS: We incl...
Source: American Journal of Hypertension - November 17, 2020 Category: Cardiology Authors: Bundy JD, Jaeger BC, Huffman MD, Knox SS, Thomas SJ, Shimbo D, Booth Iii JN, Lewis CE, Edwards LJ, Schwartz JE, Muntner P Tags: Am J Hypertens Source Type: research

Risk of Atrial Fibrillation in Masked and White Coat Uncontrolled Hypertension.
CONCLUSIONS: When compared to patients with CH, those with MUCH and SUCH are at higher risk (approximately doubled) of new-onset AF, whereas those with WUCH are not. PMID: 33186441 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - November 13, 2020 Category: Cardiology Authors: Coccina F, Pierdomenico AM, De Rosa M, Belli L, Foglietta M, Petrilli I, Vitulli P, Pizzicannella J, Trubiani O, Cipollone F, Renda G, Pierdomenico SD Tags: Am J Hypertens Source Type: research

The Association of Orthostatic Hypotension with Ambulatory Blood Pressure Phenotypes in SPRINT.
We examined the association of OH with WCE and night-to-daytime systolic BP (SBP) in a subpopulation of SPRINT, a randomized trial testing the effects of intensive or standard (
Source: American Journal of Hypertension - November 13, 2020 Category: Cardiology Authors: Ghazi L, Drawz PE, Pajewski NM, Juraschek SP Tags: Am J Hypertens Source Type: research

Variability of Aldosterone Measurements During Adrenal Venous Sampling for Primary Aldosteronism.
CONCLUSIONS: Circulating aldosterone levels can reach nadirs conventionally considered incompatible with the primary aldosteronism diagnosis, and adrenal venous aldosterone concentrations exhibit acute variability that can confound AVS interpretation. A single venous aldosterone measurement lacks precision and reproducibility in primary aldosteronism. PMID: 33179734 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - November 12, 2020 Category: Cardiology Authors: Yozamp N, Hundemer GL, Moussa M, Underhill J, Fudim T, Sacks B, Vaidya A Tags: Am J Hypertens Source Type: research

Vasohibin-2 Aggravates Development of Ascending Aortic Aneurysms But Not Abdominal Aortic Aneurysms Nor Atherosclerosis in ApoE Deficient Mice.
CONCLUSION: The present study demonstrated that augmented VASH2 expression had no effect of AngII-induced abdominal AAs or atherosclerosis, while increasing dilation in the ascending aorta. PMID: 33180898 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - November 12, 2020 Category: Cardiology Authors: Otaka N, Uchida HA, Okuyama M, Hada Y, Onishi Y, Kakio Y, Takeuchi H, Umebayashi R, Tanabe K, Subramanian V, Daugherty A, Sato Y, Wada J Tags: Am J Hypertens Source Type: research

Sex and Age Differences in Ambulatory Blood Pressure Monitoring Tolerability.
CONCLUSIONS: Although ABPM was generally well-tolerated overall, we did identify age and sex differences in tolerability. These factors should be considered to ensure patient acceptance and tolerability of ABPM. PMID: 33180905 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - November 12, 2020 Category: Cardiology Authors: Khaddage SJ, Patterson JA, Sargent LJ, Price ET, Dixon DL Tags: Am J Hypertens Source Type: research

Effect of the Nonsteroidal Mineralocorticoid Receptor Blocker, Esaxerenone, on Nocturnal Hypertension: A Post Hoc Analysis of the ESAX-HTN Study.
CONCLUSIONS: Esaxerenone may be an effective treatment option for nocturnal hypertension, especially in older patients and those with a non-dipper pattern of nocturnal BP. PMID: 33165570 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - November 9, 2020 Category: Cardiology Authors: Kario K, Ito S, Itoh H, Rakugi H, Okuda Y, Yoshimura M, Yamakawa S Tags: Am J Hypertens Source Type: research

How important is the assessment of soluble ACE-2 in COVID-19?
group PMID: 33156903 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - November 6, 2020 Category: Cardiology Authors: Rojas M, Acosta-Ampudia Y, M Monsalve D, Ramírez-Santana C, Anaya JM, CP-COVID-19 group Tags: Am J Hypertens Source Type: research

Angiotensin Converting Enzyme Inhibitors, Angiotensin Receptor Blockers and COVID-19: Demonstrating the Actionability of Real World Evidence.
PMID: 33156920 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - November 6, 2020 Category: Cardiology Authors: Hennessy S, Cohen JB Tags: Am J Hypertens Source Type: research

Corrigendum to: Uric Acid Is Not Associated With Blood Pressure Phenotypes and Target Organ Damage According to Blood Pressure Phenotypes.
Authors: PMID: 33150932 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - November 5, 2020 Category: Cardiology Tags: Am J Hypertens Source Type: research

ACE2 and SARS-CoV-2 - tissue or plasma, good or bad?
PMID: 33151267 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - November 5, 2020 Category: Cardiology Authors: Wenzel UO, Kintscher U Tags: Am J Hypertens Source Type: research

Corrigendum to: Reserpine: A New Consideration of an Old Drug for Refractory Hypertension.
Authors: PMID: 33152063 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - November 5, 2020 Category: Cardiology Tags: Am J Hypertens Source Type: research

Automated non-invasive central blood pressure measurements by oscillometric radial pulse wave analysis - results of the MEASURE-cBP validation studies.
Abstract BACKGROUND: Central blood pressure becomes increasingly accepted as an important diagnostic and therapeutic parameter in the management of cardiovascular disease. This led to development of several non-invasive techniques most commonly based on peripheral pulse wave analysis. Accuracy of widespread applanation tonometry can be affected by calibration and operator training. To overcome this, we aimed to evaluate a novel device (VascAssist 2) using automated oscillometric radial pulse wave analysis and a refined multi-compartment model of the arterial tree. METHODS: 225 patients were prospectively enro...
Source: American Journal of Hypertension - November 3, 2020 Category: Cardiology Authors: Trinkmann F, Benck U, Halder J, Semmelweis A, Saur J, Borggrefe M, Akin I, Kaden JJ Tags: Am J Hypertens Source Type: research

Characteristics of US adults who would be recommended for lifestyle modification without antihypertensive medication to manage blood pressure.
CONCLUSIONS: One fifth of US adults met 2017 ACC/AHA BP Guideline criteria for lifestyle modification alone, and many reported attempting behavior change. However, barriers exist such as insurance gaps, limited access to care, and physical impairment. PMID: 33120415 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - October 29, 2020 Category: Cardiology Authors: Jackson SL, Park S, Loustalot F, Thompson-Paul AM, Hong Y, Ritchey M Tags: Am J Hypertens Source Type: research

Rationale and design of the genotype-blinded trial of torasemide for the treatment of hypertension (BHF UMOD).
CONCLUSIONS: If hypothesis confirmed, a targeted strategy will improve BP control and could reduce the burden of uncontrolled hypertension. PMID: 33084880 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - October 21, 2020 Category: Cardiology Authors: McCallum L, Brooksbank K, McConnachie A, Aman A, Lip S, Dawson J, MacIntyre IM, MacDonald TM, Webb DJ, Padmanabhan S Tags: Am J Hypertens Source Type: research

Compendium on Hypertension: The Microbiome, Inflammation and Oxidative Stress, the Sympathetic Nervous System and Treatment of Hypertension.
PMID: 33085955 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - October 21, 2020 Category: Cardiology Authors: Schiffrin EL Tags: Am J Hypertens Source Type: research

Impact of Mineralocorticoid Receptor And Angiotensin Ii Type 1 Receptor Antagonism on Blood Pressure Regulation in Obese Zucker Rats: Role of Sex Differences.
CONCLUSIONS: These results suggest that there are important sex differences in BP responses to chronic AT1R blockade but no major involvement of MR activation in BP regulation in OZR. PMID: 33075125 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - October 19, 2020 Category: Cardiology Authors: do Carmo JM, da Silva AA, Hall JE Tags: Am J Hypertens Source Type: research

Pancreatic microcirculation profiles in the progression of hypertension in spontaneously hypertensive rats.
CONCLUSIONS: Pancreatic microcirculation profiles are abnormal in the progression of hypertension in SHRs, including a disarranged blood distribution pattern, impaired microvascular vasomotion and reduced amplitudes of endothelial oscillators. PMID: 33057586 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - October 15, 2020 Category: Cardiology Authors: Liu M, Song X, Wang B, Li Y, Li A, Zhang J, Zhang H, Xiu R Tags: Am J Hypertens Source Type: research

Renin-angiotensin-aldosterone system inhibitors and COVID-19 infection or hospitalization: a cohort study.
Abstract BACKGROUND: Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) may increase the risk of COVID-19 infection or affect disease severity. Prior studies have not examined the association of medication dose with risks. METHODS: This retrospective cohort study included people aged ≥18 years enrolled in a US integrated healthcare system for at least 4 months as of 2/29/2020. Current ACEI and ARB use was identified from pharmacy data, and the estimated daily dose was calculated and standardized across medications. COVID-19 infections and hospitalizations were identif...
Source: American Journal of Hypertension - October 13, 2020 Category: Cardiology Authors: Dublin S, Walker R, Floyd JS, Shortreed SM, Fuller S, Albertson-Junkans L, Harrington LB, Greenwood-Hickman MA, Green BB, Psaty BM Tags: Am J Hypertens Source Type: research

Actigraphy-derived Sleep Efficiency is Associated with Endothelial Function in Men and Women with Untreated Hypertension.
CONCLUSION: Poor sleep as indicated by low sleep efficiency was associated with impaired FMD. These findings for sleep efficiency are consistent with previous observations of other measures implicating poor sleep as a CVD risk factor. Interventions that improve sleep may also help lower CVD risk. PMID: 33048161 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - October 13, 2020 Category: Cardiology Authors: Hill LK, Wu JQ, Hinderliter AL, Blumenthal JA, Sherwood A Tags: Am J Hypertens Source Type: research

Serum ACE-2, angiotensin II, and aldosterone levels are unchanged in patients with COVID-19.
CONCLUSIONS: In summary, we did not find evidence for altered RAAS activity including angiotensin II, aldosterone, or potassium levels, and blood pressure in patients with COVID-19. PMID: 33043967 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - October 12, 2020 Category: Cardiology Authors: Rieder M, Wirth L, Pollmeier L, Jeserich M, Goller I, Baldus N, Schmid B, Busch HJ, Hofmann M, Kern W, Bode C, Duerschmied D, Lother A Tags: Am J Hypertens Source Type: research

Associations between Arterial Stiffness Indices and Chronic Kidney Disease Categories in Essential Hypertensive Patients.
This study investigated the association between arterial stiffness indices and asymptomatic chronic kidney disease (CKD) risk categories in hypertensive patients. METHODS: Arterial stiffness indices, including 24-hour brachial and aortic systolic blood pressure (SBP) and pulse wave velocity (PWV), were measured by an oscillometric Mobil-O-Graph device, brachial-ankle PWV by a volume-plethysmographic method, and renal resistive index (RI) by ultrasonography, in 184 essential hypertensive patients (66.0±17.1 years, 47.3% male). CKD was categorized into three stages based on the Kidney Disease Improving Global Out...
Source: American Journal of Hypertension - October 8, 2020 Category: Cardiology Authors: Kusunoki H, Iwashima Y, Kawano Y, Ohta Y, Hayashi SI, Horio T, Shinmura K, Ishimitsu T, Yoshihara F Tags: Am J Hypertens Source Type: research