Epigenetic-based targeted therapies for well-differentiated pancreatic neuroendocrine tumors: recent advances and future perspectives
Expert Rev Endocrinol Metab. 2021 Sep 23:1-13. doi: 10.1080/17446651.2021.1982382. Online ahead of print.ABSTRACTINTRODUCTION: Well-differentiated pancreatic neuroendocrine tumors (PanNETs) are a heterogeneous group of primary tumors of the endocrine pancreas. Dysregulation of chromatin remodeling, gene expression alteration, global DNA hypomethylation of non-coding regions, DNA hypermethylation and silencing of tumor suppressor gene promoters are frequent epigenetic changes in PanNETs. These changes exert a role in neoplastic transformation and progression. As epigenetic mechanisms, converse to genetic mutations, are pote...
Source: Expert Review of Endocrinology and Metabolism - September 23, 2021 Category: Endocrinology Authors: Francesca Marini Francesca Giusti Maria Luisa Brandi Source Type: research

Does abdominal obesity influence immunological response to SARS-CoV-2 infection?
Expert Rev Endocrinol Metab. 2021 Sep 17:1-2. doi: 10.1080/17446651.2021.1979392. Online ahead of print.NO ABSTRACTPMID:34533093 | PMC:PMC8459928 | DOI:10.1080/17446651.2021.1979392 (Source: Expert Review of Endocrinology and Metabolism)
Source: Expert Review of Endocrinology and Metabolism - September 17, 2021 Category: Endocrinology Authors: Fabian Sanchis-Gomar Carl J Lavie Ian J Neeland Giuseppe Lippi Source Type: research

Does abdominal obesity influence immunological response to SARS-CoV-2 infection?
Expert Rev Endocrinol Metab. 2021 Sep 17:1-2. doi: 10.1080/17446651.2021.1979392. Online ahead of print.NO ABSTRACTPMID:34533093 | DOI:10.1080/17446651.2021.1979392 (Source: Expert Review of Endocrinology and Metabolism)
Source: Expert Review of Endocrinology and Metabolism - September 17, 2021 Category: Endocrinology Authors: Fabian Sanchis-Gomar Carl J Lavie Ian J Neeland Giuseppe Lippi Source Type: research

Nocturnal hypoglycemia in type 1 and type 2 diabetes: an update on prevalence, prevention, pathophysiology and patient awareness
Expert Rev Endocrinol Metab. 2021 Sep 15:1-13. doi: 10.1080/17446651.2021.1979391. Online ahead of print.ABSTRACTINTRODUCTION: Despite considerable progress in diabetes treatment, prevalence of nocturnal hypoglycemia in type 1 diabetes mellitus (T1DM) and advanced insulin treated type 2 diabetes mellitus (T2DM) remains high.AREAS COVERED: The present manuscript describes the prevalence of night-time hypoglycemia as reported in observational and randomized controlled trials. Factors that affect the risk of hypoglycemia are highlighted. The authors also describe impaired awareness of hypoglycemia and available preventive met...
Source: Expert Review of Endocrinology and Metabolism - September 16, 2021 Category: Endocrinology Authors: Maka Siamashvili Hugh A Davis Stephen N Davis Source Type: research

Adrenal insufficiency in HIV/AIDS: a review
Expert Rev Endocrinol Metab. 2021 Sep 14:1-12. doi: 10.1080/17446651.2021.1979393. Online ahead of print.ABSTRACTINTRODUCTION: Adrenal insufficiency (AI) is one of the most common potentially life-threatening endocrine complications in people living with human immunodeficiency virus (PLHIV) infection and acquired immunodeficiency syndrome (AIDS).AREAS COVERED: In this review, the authors explore the definitions of relative AI, primary AI, secondary AI and peripheral glucocorticoid resistance in PLHIV. It also focuses on the pathophysiology, etiology, diagnosis and management of this endocrinopathy in PLHIV. A literature re...
Source: Expert Review of Endocrinology and Metabolism - September 15, 2021 Category: Endocrinology Authors: Simon Mifsud Zachary Gauci Mark Gruppetta Charles Mallia Azzopardi Stephen Fava Source Type: research

GERD and Barrett's esophagus as indications for revisional surgery after sleeve gastrectomy: experience of a bariatric center of excellence IFSO-EC and narrative review
Expert Rev Endocrinol Metab. 2021 Sep;16(5):229-235. doi: 10.1080/17446651.2021.1967742. Epub 2021 Aug 23.ABSTRACTINTRODUCTION: Laparoscopic sleeve gastrectomy is the most commonly performed bariatric procedure worldwide; due to its extensive impact and analysis, multiple procedure-related early and late complications have been described. Gastroesophageal reflux and Barrett's esophagus are highly debated issues related to sleeve gastrectomy in long-term follow-up. This review aims to explore the association between sleeve gastrectomy and gastroesophageal reflux in terms of their occurrence, and to analyze the protective or...
Source: Expert Review of Endocrinology and Metabolism - August 23, 2021 Category: Endocrinology Authors: Gianfranco Silecchia Angelo Iossa Source Type: research

Association of hypothyroidism with acute COVID-19: a systematic review
CONCLUSION: This systematic review reveals a significant proportion of hypothyroidism associated with COVID-19. Therefore, routine assessment of thyroid function is warranted in hospitalized COVID-19 patients.PMID:34424110 | DOI:10.1080/17446651.2021.1968830 (Source: Expert Review of Endocrinology and Metabolism)
Source: Expert Review of Endocrinology and Metabolism - August 23, 2021 Category: Endocrinology Authors: Jahanzeb Malik Syed Muhammad Jawad Zaidi Ali Umer Waqar Hashir Khawaja Asmara Malik Uzma Ishaq Abdul Sattar Rana Ali Haider Awan Source Type: research

GERD and Barrett's esophagus as indications for revisional surgery after sleeve gastrectomy: experience of a bariatric center of excellence IFSO-EC and narrative review
Expert Rev Endocrinol Metab. 2021 Sep;16(5):229-235. doi: 10.1080/17446651.2021.1967742. Epub 2021 Aug 23.ABSTRACTINTRODUCTION: Laparoscopic sleeve gastrectomy is the most commonly performed bariatric procedure worldwide; due to its extensive impact and analysis, multiple procedure-related early and late complications have been described. Gastroesophageal reflux and Barrett's esophagus are highly debated issues related to sleeve gastrectomy in long-term follow-up. This review aims to explore the association between sleeve gastrectomy and gastroesophageal reflux in terms of their occurrence, and to analyze the protective or...
Source: Expert Review of Endocrinology and Metabolism - August 23, 2021 Category: Endocrinology Authors: Gianfranco Silecchia Angelo Iossa Source Type: research

Association of hypothyroidism with acute COVID-19: a systematic review
CONCLUSION: This systematic review reveals a significant proportion of hypothyroidism associated with COVID-19. Therefore, routine assessment of thyroid function is warranted in hospitalized COVID-19 patients.PMID:34424110 | DOI:10.1080/17446651.2021.1968830 (Source: Expert Review of Endocrinology and Metabolism)
Source: Expert Review of Endocrinology and Metabolism - August 23, 2021 Category: Endocrinology Authors: Jahanzeb Malik Syed Muhammad Jawad Zaidi Ali Umer Waqar Hashir Khawaja Asmara Malik Uzma Ishaq Abdul Sattar Rana Ali Haider Awan Source Type: research

GERD and Barrett's esophagus as indications for revisional surgery after sleeve gastrectomy: experience of a bariatric center of excellence IFSO-EC and narrative review
Expert Rev Endocrinol Metab. 2021 Sep;16(5):229-235. doi: 10.1080/17446651.2021.1967742. Epub 2021 Aug 23.ABSTRACTINTRODUCTION: Laparoscopic sleeve gastrectomy is the most commonly performed bariatric procedure worldwide; due to its extensive impact and analysis, multiple procedure-related early and late complications have been described. Gastroesophageal reflux and Barrett's esophagus are highly debated issues related to sleeve gastrectomy in long-term follow-up. This review aims to explore the association between sleeve gastrectomy and gastroesophageal reflux in terms of their occurrence, and to analyze the protective or...
Source: Expert Review of Endocrinology and Metabolism - August 23, 2021 Category: Endocrinology Authors: Gianfranco Silecchia Angelo Iossa Source Type: research

Association of hypothyroidism with acute COVID-19: a systematic review
CONCLUSION: This systematic review reveals a significant proportion of hypothyroidism associated with COVID-19. Therefore, routine assessment of thyroid function is warranted in hospitalized COVID-19 patients.PMID:34424110 | DOI:10.1080/17446651.2021.1968830 (Source: Expert Review of Endocrinology and Metabolism)
Source: Expert Review of Endocrinology and Metabolism - August 23, 2021 Category: Endocrinology Authors: Jahanzeb Malik Syed Muhammad Jawad Zaidi Ali Umer Waqar Hashir Khawaja Asmara Malik Uzma Ishaq Abdul Sattar Rana Ali Haider Awan Source Type: research

GERD and Barrett's esophagus as indications for revisional surgery after sleeve gastrectomy: experience of a bariatric center of excellence IFSO-EC and narrative review
Expert Rev Endocrinol Metab. 2021 Sep;16(5):229-235. doi: 10.1080/17446651.2021.1967742. Epub 2021 Aug 23.ABSTRACTINTRODUCTION: Laparoscopic sleeve gastrectomy is the most commonly performed bariatric procedure worldwide; due to its extensive impact and analysis, multiple procedure-related early and late complications have been described. Gastroesophageal reflux and Barrett's esophagus are highly debated issues related to sleeve gastrectomy in long-term follow-up. This review aims to explore the association between sleeve gastrectomy and gastroesophageal reflux in terms of their occurrence, and to analyze the protective or...
Source: Expert Review of Endocrinology and Metabolism - August 23, 2021 Category: Endocrinology Authors: Gianfranco Silecchia Angelo Iossa Source Type: research

Association of hypothyroidism with acute COVID-19: a systematic review
CONCLUSION: This systematic review reveals a significant proportion of hypothyroidism associated with COVID-19. Therefore, routine assessment of thyroid function is warranted in hospitalized COVID-19 patients.PMID:34424110 | DOI:10.1080/17446651.2021.1968830 (Source: Expert Review of Endocrinology and Metabolism)
Source: Expert Review of Endocrinology and Metabolism - August 23, 2021 Category: Endocrinology Authors: Jahanzeb Malik Syed Muhammad Jawad Zaidi Ali Umer Waqar Hashir Khawaja Asmara Malik Uzma Ishaq Abdul Sattar Rana Ali Haider Awan Source Type: research

GERD and Barrett's esophagus as indications for revisional surgery after sleeve gastrectomy: experience of a bariatric center of excellence IFSO-EC and narrative review
Expert Rev Endocrinol Metab. 2021 Sep;16(5):229-235. doi: 10.1080/17446651.2021.1967742. Epub 2021 Aug 23.ABSTRACTINTRODUCTION: Laparoscopic sleeve gastrectomy is the most commonly performed bariatric procedure worldwide; due to its extensive impact and analysis, multiple procedure-related early and late complications have been described. Gastroesophageal reflux and Barrett's esophagus are highly debated issues related to sleeve gastrectomy in long-term follow-up. This review aims to explore the association between sleeve gastrectomy and gastroesophageal reflux in terms of their occurrence, and to analyze the protective or...
Source: Expert Review of Endocrinology and Metabolism - August 23, 2021 Category: Endocrinology Authors: Gianfranco Silecchia Angelo Iossa Source Type: research

Association of hypothyroidism with acute COVID-19: a systematic review
CONCLUSION: This systematic review reveals a significant proportion of hypothyroidism associated with COVID-19. Therefore, routine assessment of thyroid function is warranted in hospitalized COVID-19 patients.PMID:34424110 | DOI:10.1080/17446651.2021.1968830 (Source: Expert Review of Endocrinology and Metabolism)
Source: Expert Review of Endocrinology and Metabolism - August 23, 2021 Category: Endocrinology Authors: Jahanzeb Malik Syed Muhammad Jawad Zaidi Ali Umer Waqar Hashir Khawaja Asmara Malik Uzma Ishaq Abdul Sattar Rana Ali Haider Awan Source Type: research

GERD and Barrett's esophagus as indications for revisional surgery after sleeve gastrectomy: experience of a bariatric center of excellence IFSO-EC and narrative review
Expert Rev Endocrinol Metab. 2021 Sep;16(5):229-235. doi: 10.1080/17446651.2021.1967742. Epub 2021 Aug 23.ABSTRACTINTRODUCTION: Laparoscopic sleeve gastrectomy is the most commonly performed bariatric procedure worldwide; due to its extensive impact and analysis, multiple procedure-related early and late complications have been described. Gastroesophageal reflux and Barrett's esophagus are highly debated issues related to sleeve gastrectomy in long-term follow-up. This review aims to explore the association between sleeve gastrectomy and gastroesophageal reflux in terms of their occurrence, and to analyze the protective or...
Source: Expert Review of Endocrinology and Metabolism - August 23, 2021 Category: Endocrinology Authors: Gianfranco Silecchia Angelo Iossa Source Type: research

Association of hypothyroidism with acute COVID-19: a systematic review
CONCLUSION: This systematic review reveals a significant proportion of hypothyroidism associated with COVID-19. Therefore, routine assessment of thyroid function is warranted in hospitalized COVID-19 patients.PMID:34424110 | DOI:10.1080/17446651.2021.1968830 (Source: Expert Review of Endocrinology and Metabolism)
Source: Expert Review of Endocrinology and Metabolism - August 23, 2021 Category: Endocrinology Authors: Jahanzeb Malik Syed Muhammad Jawad Zaidi Ali Umer Waqar Hashir Khawaja Asmara Malik Uzma Ishaq Abdul Sattar Rana Ali Haider Awan Source Type: research

GERD and Barrett's esophagus as indications for revisional surgery after sleeve gastrectomy: experience of a bariatric center of excellence IFSO-EC and narrative review
Expert Rev Endocrinol Metab. 2021 Aug 23:1-7. doi: 10.1080/17446651.2021.1967742. Online ahead of print.ABSTRACTINTRODUCTION: Laparoscopic sleeve gastrectomy is the most commonly performed bariatric procedure worldwide; due to its extensive impact and analysis, multiple procedure-related early and late complications have been described. Gastroesophageal reflux and Barrett's esophagus are highly debated issues related to sleeve gastrectomy in long-term follow-up. This review aims to explore the association between sleeve gastrectomy and gastroesophageal reflux in terms of their occurrence, and to analyze the protective or a...
Source: Expert Review of Endocrinology and Metabolism - August 23, 2021 Category: Endocrinology Authors: Gianfranco Silecchia Angelo Iossa Source Type: research

Association of hypothyroidism with acute COVID-19: a systematic review
CONCLUSION: This systematic review reveals a significant proportion of hypothyroidism associated with COVID-19. Therefore, routine assessment of thyroid function is warranted in hospitalized COVID-19 patients.PMID:34424110 | DOI:10.1080/17446651.2021.1968830 (Source: Expert Review of Endocrinology and Metabolism)
Source: Expert Review of Endocrinology and Metabolism - August 23, 2021 Category: Endocrinology Authors: Jahanzeb Malik Syed Muhammad Jawad Zaidi Ali Umer Waqar Hashir Khawaja Asmara Malik Uzma Ishaq Abdul Sattar Rana Ali Haider Awan Source Type: research

GERD and Barrett's esophagus as indications for revisional surgery after sleeve gastrectomy: experience of a bariatric center of excellence IFSO-EC and narrative review
Expert Rev Endocrinol Metab. 2021 Aug 23:1-7. doi: 10.1080/17446651.2021.1967742. Online ahead of print.ABSTRACTINTRODUCTION: Laparoscopic sleeve gastrectomy is the most commonly performed bariatric procedure worldwide; due to its extensive impact and analysis, multiple procedure-related early and late complications have been described. Gastroesophageal reflux and Barrett's esophagus are highly debated issues related to sleeve gastrectomy in long-term follow-up. This review aims to explore the association between sleeve gastrectomy and gastroesophageal reflux in terms of their occurrence, and to analyze the protective or a...
Source: Expert Review of Endocrinology and Metabolism - August 23, 2021 Category: Endocrinology Authors: Gianfranco Silecchia Angelo Iossa Source Type: research

Association of hypothyroidism with acute COVID-19: a systematic review
CONCLUSION: This systematic review reveals a significant proportion of hypothyroidism associated with COVID-19. Therefore, routine assessment of thyroid function is warranted in hospitalized COVID-19 patients.PMID:34424110 | DOI:10.1080/17446651.2021.1968830 (Source: Expert Review of Endocrinology and Metabolism)
Source: Expert Review of Endocrinology and Metabolism - August 23, 2021 Category: Endocrinology Authors: Jahanzeb Malik Syed Muhammad Jawad Zaidi Ali Umer Waqar Hashir Khawaja Asmara Malik Uzma Ishaq Abdul Sattar Rana Ali Haider Awan Source Type: research

GERD and Barrett's esophagus as indications for revisional surgery after sleeve gastrectomy: experience of a bariatric center of excellence IFSO-EC and narrative review
Expert Rev Endocrinol Metab. 2021 Aug 23:1-7. doi: 10.1080/17446651.2021.1967742. Online ahead of print.ABSTRACTINTRODUCTION: Laparoscopic sleeve gastrectomy is the most commonly performed bariatric procedure worldwide; due to its extensive impact and analysis, multiple procedure-related early and late complications have been described. Gastroesophageal reflux and Barrett's esophagus are highly debated issues related to sleeve gastrectomy in long-term follow-up. This review aims to explore the association between sleeve gastrectomy and gastroesophageal reflux in terms of their occurrence, and to analyze the protective or a...
Source: Expert Review of Endocrinology and Metabolism - August 23, 2021 Category: Endocrinology Authors: Gianfranco Silecchia Angelo Iossa Source Type: research

Association of hypothyroidism with acute COVID-19: a systematic review
CONCLUSION: This systematic review reveals a significant proportion of hypothyroidism associated with COVID-19. Therefore, routine assessment of thyroid function is warranted in hospitalized COVID-19 patients.PMID:34424110 | DOI:10.1080/17446651.2021.1968830 (Source: Expert Review of Endocrinology and Metabolism)
Source: Expert Review of Endocrinology and Metabolism - August 23, 2021 Category: Endocrinology Authors: Jahanzeb Malik Syed Muhammad Jawad Zaidi Ali Umer Waqar Hashir Khawaja Asmara Malik Uzma Ishaq Abdul Sattar Rana Ali Haider Awan Source Type: research

GERD and Barrett's esophagus as indications for revisional surgery after sleeve gastrectomy: experience of a bariatric center of excellence IFSO-EC and narrative review
Expert Rev Endocrinol Metab. 2021 Aug 23:1-7. doi: 10.1080/17446651.2021.1967742. Online ahead of print.ABSTRACTINTRODUCTION: Laparoscopic sleeve gastrectomy is the most commonly performed bariatric procedure worldwide; due to its extensive impact and analysis, multiple procedure-related early and late complications have been described. Gastroesophageal reflux and Barrett's esophagus are highly debated issues related to sleeve gastrectomy in long-term follow-up. This review aims to explore the association between sleeve gastrectomy and gastroesophageal reflux in terms of their occurrence, and to analyze the protective or a...
Source: Expert Review of Endocrinology and Metabolism - August 23, 2021 Category: Endocrinology Authors: Gianfranco Silecchia Angelo Iossa Source Type: research

Association of hypothyroidism with acute COVID-19: a systematic review
CONCLUSION: This systematic review reveals a significant proportion of hypothyroidism associated with COVID-19. Therefore, routine assessment of thyroid function is warranted in hospitalized COVID-19 patients.PMID:34424110 | DOI:10.1080/17446651.2021.1968830 (Source: Expert Review of Endocrinology and Metabolism)
Source: Expert Review of Endocrinology and Metabolism - August 23, 2021 Category: Endocrinology Authors: Jahanzeb Malik Syed Muhammad Jawad Zaidi Ali Umer Waqar Hashir Khawaja Asmara Malik Uzma Ishaq Abdul Sattar Rana Ali Haider Awan Source Type: research

GERD and Barrett's esophagus as indications for revisional surgery after sleeve gastrectomy: experience of a bariatric center of excellence IFSO-EC and narrative review
Expert Rev Endocrinol Metab. 2021 Aug 23:1-7. doi: 10.1080/17446651.2021.1967742. Online ahead of print.ABSTRACTINTRODUCTION: Laparoscopic sleeve gastrectomy is the most commonly performed bariatric procedure worldwide; due to its extensive impact and analysis, multiple procedure-related early and late complications have been described. Gastroesophageal reflux and Barrett's esophagus are highly debated issues related to sleeve gastrectomy in long-term follow-up. This review aims to explore the association between sleeve gastrectomy and gastroesophageal reflux in terms of their occurrence, and to analyze the protective or a...
Source: Expert Review of Endocrinology and Metabolism - August 23, 2021 Category: Endocrinology Authors: Gianfranco Silecchia Angelo Iossa Source Type: research

Association of hypothyroidism with acute COVID-19: a systematic review
CONCLUSION: This systematic review reveals a significant proportion of hypothyroidism associated with COVID-19. Therefore, routine assessment of thyroid function is warranted in hospitalized COVID-19 patients.PMID:34424110 | DOI:10.1080/17446651.2021.1968830 (Source: Expert Review of Endocrinology and Metabolism)
Source: Expert Review of Endocrinology and Metabolism - August 23, 2021 Category: Endocrinology Authors: Jahanzeb Malik Syed Muhammad Jawad Zaidi Ali Umer Waqar Hashir Khawaja Asmara Malik Uzma Ishaq Abdul Sattar Rana Ali Haider Awan Source Type: research

Colorectal cancer causes alteration of thyroid hormone profile in newly diagnosed patients
CONCLUSION: The elevation of rT3 in CRC patients can probably be due to the re-expression of deiodinase type 3 in CRC. Further research is needed to study the role of intracellular THs modulation in CRC and its impact on CRC treatment.PMID:34404289 | DOI:10.1080/17446651.2021.1967744 (Source: Expert Review of Endocrinology and Metabolism)
Source: Expert Review of Endocrinology and Metabolism - August 18, 2021 Category: Endocrinology Authors: Ghazaleh Shimi Hamid Zand Katayoun Pourvali Arman Ghorbani Source Type: research

What can hand grip strength tell us about type 2 diabetes?: mortality, morbidities and risk of diabetes
Expert Rev Endocrinol Metab. 2021 Aug 17:1-14. doi: 10.1080/17446651.2021.1967743. Online ahead of print.ABSTRACTINTRODUCTION: Hand grip strength (HGS) has been determined as a simple and cost effective method for evaluating overall skeletal muscle strength and quality. It has been used in numerous clinical studies to examine the association between skeletal muscle and type 2 diabetes (T2D). Previous studies have shown that HGS is significantly associated with mortality and cardiovascular disease (CVD) in patients with T2D. As the prevalence of T2D has seen a steady increase globally, HGS measurement can be useful and esse...
Source: Expert Review of Endocrinology and Metabolism - August 17, 2021 Category: Endocrinology Authors: Hidetaka Hamasaki Source Type: research

Assessment of serum cortisol and thyrotropin correlation in euthyroid and subclinical hypothyroid subjects
Expert Rev Endocrinol Metab. 2021 Aug 17:1-7. doi: 10.1080/17446651.2021.1968829. Online ahead of print.ABSTRACTRESEARCH DESIGN AND METHODS: This cross-sectional study was performed on healthy volunteers and those who had been referred with a diagnosis of subclinical hypothyroidism (TSH
Source: Expert Review of Endocrinology and Metabolism - August 17, 2021 Category: Endocrinology Authors: Zahra Heidari Ashkan Hajbagheri Source Type: research

What can hand grip strength tell us about type 2 diabetes?: mortality, morbidities and risk of diabetes
Expert Rev Endocrinol Metab. 2021 Aug 17:1-14. doi: 10.1080/17446651.2021.1967743. Online ahead of print.ABSTRACTINTRODUCTION: Hand grip strength (HGS) has been determined as a simple and cost effective method for evaluating overall skeletal muscle strength and quality. It has been used in numerous clinical studies to examine the association between skeletal muscle and type 2 diabetes (T2D). Previous studies have shown that HGS is significantly associated with mortality and cardiovascular disease (CVD) in patients with T2D. As the prevalence of T2D has seen a steady increase globally, HGS measurement can be useful and esse...
Source: Expert Review of Endocrinology and Metabolism - August 17, 2021 Category: Endocrinology Authors: Hidetaka Hamasaki Source Type: research

Assessment of serum cortisol and thyrotropin correlation in euthyroid and subclinical hypothyroid subjects
Expert Rev Endocrinol Metab. 2021 Aug 17:1-7. doi: 10.1080/17446651.2021.1968829. Online ahead of print.ABSTRACTRESEARCH DESIGN AND METHODS: This cross-sectional study was performed on healthy volunteers and those who had been referred with a diagnosis of subclinical hypothyroidism (TSH
Source: Expert Review of Endocrinology and Metabolism - August 17, 2021 Category: Endocrinology Authors: Zahra Heidari Ashkan Hajbagheri Source Type: research

Levoketoconazole: a novel treatment for endogenous Cushing's syndrome
Expert Rev Endocrinol Metab. 2021 Aug 12:1-16. doi: 10.1080/17446651.2021.1945440. Online ahead of print.ABSTRACTIntroduction: Endogenous Cushing's syndrome (CS) is a rare, life-threatening endocrine disorder that is caused by chronic exposure to cortisol overproduction. Levoketoconazole (Recorlev), a 2S, 4R stereoisomer of ketoconazole, is a steroidogenesis inhibitor under investigation for the treatment of CS.Areas covered: This review covers the pharmacology, efficacy, and safety of levoketoconazole for the treatment of patients with endogenous CS.Expert opinion: Based on the preclinical and clinical pharmacology findin...
Source: Expert Review of Endocrinology and Metabolism - August 12, 2021 Category: Endocrinology Authors: Maria Fleseriu Richard J Auchus Rosario Pivonello Roberto Salvatori Sabina Zacharieva Beverly M K Biller Source Type: research

Risks vs. benefits of switching therapy in patients with postmenopausal osteoporosis
Expert Rev Endocrinol Metab. 2021 Jul 26:1-12. doi: 10.1080/17446651.2021.1956902. Online ahead of print.ABSTRACTIntroduction: Osteoporosis is characterized by the fragility of bones, leading to fractures and, consequently, the deterioration of functional capacity and quality of life. Postmenopausal women, in particular, are prone to osteoporosis and often require anti-osteoporosis treatment. In the last few decades, various anti-osteoporosis drugs have been approved for clinical use. In an aging society, osteoporosis cannot be treated using a single agent; therefore, switching therapy is an important treatment strategy.Ar...
Source: Expert Review of Endocrinology and Metabolism - July 26, 2021 Category: Endocrinology Authors: Hotaka Ishizu Kosuke Arita Mohamad Alaa Terkawi Tomohiro Shimizu Norimasa Iwasaki Source Type: research