Management of diabetes in elderly patients during the COVID-19 pandemic: current and future perspectives
We present some approaches to manage these complicated elderly patients with diabetes during the COVID-19 pandemic. In the inpatient setting, we suggest similar (pre-pandemic) glycemic targets and emphasize the importance of using IV insulin and possible use of continuous glucose monitoring to reduce exposure and PPE utilization. Outside the hospital, we recommend optimal glycemic control within the limits imposed by considerations of safety. We also describe the advantages and challenges of using various technological platforms in clinical care.Expert opinion: The COVID-19 pandemic has lifted the veil off serious deficien...
Source: Expert Review of Endocrinology and Metabolism - June 7, 2021 Category: Endocrinology Authors: Aman Rajpal Laure Sayyed Kassem David C Aron Source Type: research

Heterozygous familial hypercholesterolemia: prevalence and control rates
Expert Rev Endocrinol Metab. 2021 May 17:1-5. doi: 10.1080/17446651.2021.1929175. Online ahead of print.ABSTRACTIntroduction: Heterozygous familial hypercholesterolemia (heFH) is associated with a very high risk for cardiovascular events. Treatment with potent statins substantially reduces cardiovascular morbidity in these patients. Moreover, combination therapy with statins plus ezetimibe and/or proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors facilitates achievement of low-density lipoprotein cholesterol (LDL-C) targets in patients with heFH. However, heFH remains underdiagnosed and undertreated worldwide...
Source: Expert Review of Endocrinology and Metabolism - May 17, 2021 Category: Endocrinology Authors: Georgios Polychronopoulos Marios Tzavelas Konstantinos Tziomalos Source Type: research

Personalized fracture risk assessment: where are we at?
This article reviews recent development and validation results concerning the prognostic performance of the two tools. The main areas of review are the need for personalized fracture risk prediction, purposes of risk prediction, predictive performance in terms of discrimination and calibration, concordance between the Garvan and FRAX tools, genetic profiling for improving predictive performance, and treatment thresholds. In some validation studies, FRAX tended to underestimate fracture by as high as 50%. Studies have shown that the predicted risk from the Garvan tool is highly concordant with clinical decision. Expert opin...
Source: Expert Review of Endocrinology and Metabolism - May 13, 2021 Category: Endocrinology Authors: Tuan V Nguyen Source Type: research

Anabolic steroid misuse and male infertility: management and strategies to improve patient awareness
Expert Rev Endocrinol Metab. 2021 May 11:1-14. doi: 10.1080/17446651.2021.1921574. Online ahead of print.ABSTRACTIntroduction: Anabolic androgenic steroid use is an uncommon but important cause of male infertility. As paternal age and anabolic steroid use increases, providers are more likely than ever to encounter men with infertility and prior or concurrent anabolic steroid use. In this review, we outline the background, epidemiology and pathophysiology of anabolic steroid induced male infertility and provide recommendations regarding the diagnosis, management, and future prevention of this condition.Areas covered: Male r...
Source: Expert Review of Endocrinology and Metabolism - May 11, 2021 Category: Endocrinology Authors: Dustin L Whitaker Gabriella Geyer-Kim Edward D Kim Source Type: research

Endocrine disrupting chemicals: strategies to protect present and future generations
Expert Rev Endocrinol Metab. 2021 May 11:1-12. doi: 10.1080/17446651.2021.1917991. Online ahead of print.ABSTRACTIntroduction: Endocrine-disrupting chemicals (EDCs) are chemicals that alter the actions of hormones. In the 21st Century, numerous expert groups of clinicians, scientists, and environmental activists have called for action to protect present and future generations from the harm induced by EDC exposures. These demands for regulatory responses come because of the strong weight of the evidence from epidemiology, wildlife, and controlled laboratory studies.Areas covered: In this review, we examine the conclusions d...
Source: Expert Review of Endocrinology and Metabolism - May 11, 2021 Category: Endocrinology Authors: Laura N Vandenberg Source Type: research

Anabolic steroid misuse and male infertility: management and strategies to improve patient awareness
Expert Rev Endocrinol Metab. 2021 May 11:1-14. doi: 10.1080/17446651.2021.1921574. Online ahead of print.ABSTRACTIntroduction: Anabolic androgenic steroid use is an uncommon but important cause of male infertility. As paternal age and anabolic steroid use increases, providers are more likely than ever to encounter men with infertility and prior or concurrent anabolic steroid use. In this review, we outline the background, epidemiology and pathophysiology of anabolic steroid induced male infertility and provide recommendations regarding the diagnosis, management, and future prevention of this condition.Areas covered: Male r...
Source: Expert Review of Endocrinology and Metabolism - May 11, 2021 Category: Endocrinology Authors: Dustin L Whitaker Gabriella Geyer-Kim Edward D Kim Source Type: research

Endocrine disrupting chemicals: strategies to protect present and future generations
Expert Rev Endocrinol Metab. 2021 May 11:1-12. doi: 10.1080/17446651.2021.1917991. Online ahead of print.ABSTRACTIntroduction: Endocrine-disrupting chemicals (EDCs) are chemicals that alter the actions of hormones. In the 21st Century, numerous expert groups of clinicians, scientists, and environmental activists have called for action to protect present and future generations from the harm induced by EDC exposures. These demands for regulatory responses come because of the strong weight of the evidence from epidemiology, wildlife, and controlled laboratory studies.Areas covered: In this review, we examine the conclusions d...
Source: Expert Review of Endocrinology and Metabolism - May 11, 2021 Category: Endocrinology Authors: Laura N Vandenberg Source Type: research

Beyond weight loss: current perspectives on the impact of calorie restriction on healthspan and lifespan
Expert Rev Endocrinol Metab. 2021 May 7:1-14. doi: 10.1080/17446651.2021.1922077. Online ahead of print.ABSTRACTIntroduction: Changes to mental, physical, and physiological functions drive the complex processes underlying the variable progression of human aging. Nutritional interventions are one of the most promising non-pharmacological therapeutics to attenuate aging in humans. This narrative review aims to describe the implications of moderate and prolonged calorie restriction (CR) in healthy adults without obesity that occur beyond weight loss.Areas covered: Findings from CR studies, such as the CALERIE (Comprehensive A...
Source: Expert Review of Endocrinology and Metabolism - May 7, 2021 Category: Endocrinology Authors: Maryam Kebbe Joshua R Sparks Emily W Flanagan Leanne M Redman Source Type: research

Bariatric surgery in the treatment of adolescent obesity: current perspectives in the United States
Expert Rev Endocrinol Metab. 2021 Apr 21:1-12. doi: 10.1080/17446651.2021.1914585. Online ahead of print.ABSTRACTIntroduction: Rates of severe obesity in adolescents have increased at an alarming rate. Unfortunately, there are limited successful treatments for severe obesity in adolescents. Metabolic and bariatric surgery (MBS) is the most effective treatment available for adolescents with Class 2 and above severe obesity and has demonstrated variable degrees of sustained long-term weight loss which leads to resolution of multiple associated conditions and an improved quality of life.Areas covered: We discuss the current l...
Source: Expert Review of Endocrinology and Metabolism - April 21, 2021 Category: Endocrinology Authors: Sonali Malhotra Kathryn S Czepiel Eftitan Y Akam Ashley Y Shaw Ramya Sivasubramanian Sujatha Seetharaman Fatima Cody Stanford Source Type: research