Inversion recovery and saturation recovery pulmonary vein MR angiography using an image based navigator fluoro trigger and variable-density 3D cartesian sampling with spiral-like order
We describe its use in part during the global iodinated contrast shortage. VD-CASPR/iNAV framework was applied to ECG-gated inversion and saturation recovery gradient recalled echo PV CE-MRA in 65 patients (66 exams) using .15 mmol/kg Gadobutrol. Image quality was assessed by three physician s, and anatomical segmentation quality by two technologists. Left atrial SNR and left atrial/myocardial CNR were measured. 12 patients had CTA within 6 months of MRA. Two readers assessed PV ostial measurements versus CTA for intermodality/interobserver agreement. Inter-rater/intermodality reliabil ity, reproducibility of ostial meas...
Source: The International Journal of Cardiovascular Imaging - April 27, 2024 Category: Radiology Source Type: research
Evolving role of aortic valve calcification scoring – Time for opportunistic screening?
Aortic stenosis (AS) stands as the third most prevalent cardiovascular disease worldwide afflicting over 12% of individuals aged 75 and above, a figure projected to escalate alongside population aging trends. Its ramifications extend significantly to morbidity and mortality rates.1 The most common etiology is the fibrocalcific thickening of the aortic valve leaflets leading to progressive restricted leaflet opening, with less common causes being congenital bicuspid, rheumatic fever, and radiation. (Source: Journal of Cardiovascular Computed Tomography)
Source: Journal of Cardiovascular Computed Tomography - April 27, 2024 Category: Radiology Authors: Leandro Slipczuk, Philippe Pibarot, Piotr J. Slomka, Marc R. Dweck, Damini Dey Tags: Editorial Source Type: research
Echocardiographic assessment of cardiovascular involvements in children with cystic fibrosis
Cystic fibrosis (CF) is a fatal disease in which the cystic fibrosis transmembrane conductance regulator (CTFR) gene is mutated, resulting in defect in CFTR protein dependent sodium and chloride transport activity. It has been proved that Dysfunction of CFTR leads to imbalance in regulating the conduction of sodium and chloride ions in epithelial cell membranes and increased mucosal viscosity, which eventually leads to a variety of abnormalities such as pulmonary infection and gastrointestinal involvement [1,2]. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - April 27, 2024 Category: Respiratory Medicine Authors: Hosseinali Ghaffaripour, Ali Reza Norouzi, Maryam Hassanzad, Fariba Alaei, Mohammad Reza Khalilian, Hojjat Derakhshanfar, Nasrin Elahi Mehr Tags: Original Article Source Type: research
Association of soluble suppression of tumorigenicity 2 with mortality and adverse outcomes in chronic kidney disease: a systematic review and meta-analysis
ConclusionsHigh sST2 values are associated with an increased risk of all-cause mortality in pre-dialysis and dialysis patients, as well as with an elevated risk of cardiovascular mortality in the dialysis population. Further studies are needed to elucidate its potential association with cardiovascular events and kidney disease progression. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - April 27, 2024 Category: Urology & Nephrology Source Type: research
The additive prognostic value of end-systolic pressure-volume relation by stress CMR in patients with known or suspected coronary artery disease
ConclusionΔESPVR index by stress-CMR was independently associated with cardiac outcomes in patients with known/suspected CAD, in addition to replacement myocardial fibrosis and diabetes. Thus, the assessment of ΔESPVR index may be included into the standard stress-CMR exam to further stratify the patients. (Source: The International Journal of Cardiovascular Imaging)
Source: The International Journal of Cardiovascular Imaging - April 27, 2024 Category: Radiology Source Type: research
An integrated view of cisplatin-induced nephrotoxicity, hepatotoxicity, and cardiotoxicity: characteristics, common molecular mechanisms, and current clinical management
AbstractCisplatin (CP) is a chemotherapy drug widely prescribed to treat various neoplasms. Although fundamental for the therapeutic action of the drug, its cytotoxic mechanisms trigger adverse effects in several tissues, such as the kidney, liver, and heart, which limit its clinical use. In this sense, studies point to an essential role of damage to nuclear and mitochondrial DNA associated with oxidative stress, inflammation, and apoptosis in the pathophysiology of tissue injuries. Due to the limitation of effective preventive and therapeutic measures against CP-induced toxicity, new strategies with potential cytoprotecti...
Source: Clinical and Experimental Nephrology - April 27, 2024 Category: Urology & Nephrology Source Type: research
An 11-month-old boy with tuberculous meningitis presenting as progressive limb weakness, fever, developmental retardation, and loss of consciousness: a case report
ConclusionOver half of treated TB meningitis patients die or suffer severe neurological sequelae, mainly due to late diagnosis. Hence, early diagnosis and prompt initiation of TB treatment offer the best chance of a good neurological outcome. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - April 27, 2024 Category: General Medicine Source Type: research
Ketogenic Diets Hold Therapeutic Potential Against Periodontal Inflammation
AbstractPurpose of ReviewPeriodontitis, one of the most prevalent diseases in the world, is caused by the accumulation of dysbiotic microbial biofilm on the teeth leading to chronic inflammation of the tissues surrounding the teeth. Type 2 diabetes mellitus (T2DM), obesity, chronic stress, and smoking are some of the risk factors for the disease. A high-carbohydrate diet also increases the risk of periodontal inflammation. Modifying diet and nutrition could serve as a preventive and therapeutic tool to target multiple risk factors simultaneously.Recent FindingsEmerging evidence shows that the ketogenic diet induces hormeti...
Source: Current Oral Health Reports - April 27, 2024 Category: Dentistry Source Type: research
The relationship between serum manganese concentration with all-cause and cause-specific mortality: a retrospective and population-based cross-sectional study
The study aimed to explore the association between manganese concentration and all-cause, cardiovascular disease (CVD)-related, and cancer-related mortality in the general population of the United States. (Source: BMC Cardiovascular Disorders)
Source: BMC Cardiovascular Disorders - April 27, 2024 Category: Cardiology Authors: Jianyun Ou, Yunfei Sun, Jie Tong, Weihong Tang and Genshan Ma Tags: Research Source Type: research
Bioactive adrenomedullin as a marker of congestion and disease progression in patients with a systemic right ventricle
Adults with a systemic right ventricle (sRV) are at a high risk for heart failure (HF) hospitalisation and mortality. Bioactive adrenomedullin (bio-ADM) has been proposed as a marker of congestion and prognosis in patients with cardiovascular disease. We aimed to evaluate the association between bio-ADM and mortality and HF events in sRV patients. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 27, 2024 Category: Cardiology Authors: Mohammad Mostafa Ansari Ramandi, Paul M. Hendriks, Adriaan A. Voors, Annemien E. van den Bosch, Joost P. van Melle Source Type: research
Diagnostic value of LGE and T1 mapping in multiple myeloma patients ’heart
Unidentified heart failure occurs in patients with multiple myeloma when their heart was involved. CMR with late gadolinium enhancement (LGE) and T1 mapping can identify myocardial amyloid infiltrations. (Source: BMC Cardiovascular Disorders)
Source: BMC Cardiovascular Disorders - April 27, 2024 Category: Cardiology Authors: Qian Cui, Jing Yu, Xihong Ge, Guangfeng Gao, Yang Liu, Qiang He and Wen Shen Tags: Research Source Type: research
Immunological Aspects of Kabuki Syndrome: A Retrospective Multicenter Study of the Italian Primary Immunodeficiency Network (IPINet)
In conclusion, immunological manifestations of KS in our cohort include susceptibility to infections, antibody deficiency, and autoimmunity. Autoimmune cytopenia is correlated with thymectomy and elevated CD3 + TCRαβ + CD4-CD8-T-cells, and benefits from treatment with mycophenolate. (Source: Journal of Clinical Immunology)
Source: Journal of Clinical Immunology - April 27, 2024 Category: Allergy & Immunology Source Type: research
Unlocking the potential: Baicalin's apoptosis-reducing power and activation of NRF2/P62 for alleviating diabetic cardiomyopathy in rats
ConclusionBaicalin may reduce the effects of DCM by activating NRF2 through KEAP1 suppression and regulating autophagy activation. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - April 27, 2024 Category: Cytology Source Type: research
Associations between non-insulin-based insulin resistance indices and heart failure prevalence in overweight/obesity adults without diabetes mellitus: evidence from the NHANES 2001 –2018
The triglyceride glucose (TyG) index and triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio are recognized as simple non-insulin-based insulin resistance indices. Our study aimed to explore ... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - April 27, 2024 Category: Lipidology Authors: Di-yu Cui, Chao Zhang, Yi Chen, Gang-zhen Qian, Wan-xiang Zheng, Zhi-hui Zhang, Yu Zhang and Ping Zhu Tags: Research Source Type: research
Mitral valve surgery in patients with Marfan syndrome
To review the pathology of the mitral valve (MV) and long-term outcomes of surgery in patients with Marfan syndrome (MFS). (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 27, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Tirone E. David, Joy Park, Chun-Po Steve Fan Tags: Adult Source Type: research
