Lifetime and age-conditional risk estimates of end-stage kidney disease requiring maintenance dialysis in Japan
ConclusionsConsiderable sex differences were found in the lifetime risk of ESKD in Japan. This easily understandable information could be used to assist in public health education and planning. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - February 10, 2020 Category: Urology & Nephrology Source Type: research

Clinicopathological features and outcomes of diabetic kidney disease with extracapillary hypercellularity: a Japanese single-center experience
ConclusionsEXHC is related to nodular sclerosis, which is a known risk factor for ESRD. Careful observation is needed during the follow-up of DKD patients with EXHC, although there were no significant differences in renal outcomes between the EXHC and control groups. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - February 10, 2020 Category: Urology & Nephrology Source Type: research

Profound effect of post-rituximab mycophenolate mofetil administration for persistent hypogammaglobulinemia in young children with steroid-dependent nephrotic syndrome
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - February 10, 2020 Category: Urology & Nephrology Source Type: research

Association between anemia and renal prognosis in autosomal dominant polycystic kidney disease: a retrospective study
AbstractBackgroundThough anemia is a sign of poor renal prognosis in chronic kidney disease (CKD), hemoglobin (Hb) levels are typically higher in autosomal dominant polycystic kidney disease (ADPKD) than in other kidney diseases, and anemia has not been examined as a potential prognosticator. Thus, we investigated anemia as a factor for renal prognosis in ADPKD.MethodsIn total, 115 non-dialysis patients, 48 men and 67 women, with ADPKD were evaluated. The renal outcome of a 50% reduction in the estimated glomerular filtration rate or renal replacement therapy was examined using the Cox regression analysis and Kaplan &ndash...
Source: Clinical and Experimental Nephrology - February 8, 2020 Category: Urology & Nephrology Source Type: research

New insight into podocyte slit diaphragm, a therapeutic target of proteinuria
AbstractDysfunction of slit diaphragm, a cell –cell junction of glomerular podocytes, is involved in the development of proteinuria in several glomerular diseases. Slit diaphragm should be a target of a novel therapy for proteinuria. Nephrin, NEPH1, P-cadherin, FAT, and ephrin-B1 were reported to be extracellular components forming a molecula r sieve of the slit diaphragm. Several cytoplasmic proteins such as ZO-1, podocin, CD2AP, MAGI proteins and Par-complex molecules were identified as scaffold proteins linking the slit diaphragm to the cytoskeleton. In this article, new insights into these molecules and the patho...
Source: Clinical and Experimental Nephrology - February 4, 2020 Category: Urology & Nephrology Source Type: research

Identification of children with chronic kidney disease through school urinary screening using urinary protein/creatinine ratio measurement: an observational study
ConclusionSchool urinary screening using the urinary protein/Cr ratio can efficiently refer to a specialist. It detects a few children with high-risk CKD early with spending high cost. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - January 31, 2020 Category: Urology & Nephrology Source Type: research

Anion gap predicts early mortality after starting hemodialysis in the elderly
AbstractBackgroundSerum anion gap (AG) has recently been proven to represent a biomarker for predicting prognosis in patients with end-stage renal disease (ESRD). However, whether change in AG ( ΔAG) at the time of starting hemodialysis predicts mortality after starting hemodialysis in elderly patients with ESRD remains unknown.MethodsThis retrospective cohort investigated the association between ΔAG and mortality after starting hemodialysis in the elderly. The cohort comprised patients ≥ 75 years old who started hemodialysis for ESRD at National Center for Global Health and Medicine betwe...
Source: Clinical and Experimental Nephrology - January 27, 2020 Category: Urology & Nephrology Source Type: research

Hereditary bilateral ureteropelvic junction obstruction
AbstractA 42-year-old woman presented with hypertensive crisis and bilateral hydronephrosis. She has a strong family history of ureteropelvic junction obstruction. Ureteropelvic junction obstruction is usually sporadic, unilateral, but inherited UPJO has also been reported. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - January 27, 2020 Category: Urology & Nephrology Source Type: research

Comparison of measured and calculated osmolality levels
In this study, we compared the Worthley osmolality calculation method which is used most frequently mentioned in literature and the mea surements made with vapor pressure osmometer used in our laboratory. We compared whether there was a difference between the results obtained by measurement and calculation method in different age groups.Methods221 serum samples of patients who were admitted to the Eski şehir Osmangazi University Hospital Biochemistry Laboratory between December 2016 and May 2018 were included in this study. Glucose, blood urea nitrogen and sodium values were recorded to determine the calculated osmolality...
Source: Clinical and Experimental Nephrology - January 25, 2020 Category: Urology & Nephrology Source Type: research

Dotinurad versus benzbromarone in Japanese hyperuricemic patient with or without gout: a randomized, double-blind, parallel-group, phase 3 study
ConclusionDotinurad 2  mg was verified to have a non-inferior serum uric acid lowering effect compared with benzbromarone 50 mg, in Japanese hyperuricemic patients with or without gout.ClinicalTrials.gov IdentifierNCT03100318. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - January 24, 2020 Category: Urology & Nephrology Source Type: research

A non-inferiority study of the novel selective urate reabsorption inhibitor dotinurad versus febuxostat in hyperuricemic patients with or without gout
ConclusionThe non-inferiority of dotinurad to febuxostat in terms of serum uric acid lowering effect was confirmed. No noteworthy safety concerns arose. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - January 22, 2020 Category: Urology & Nephrology Source Type: research

Correction to: Dotinurad: a novel selective urate reabsorption inhibitor as a future therapeutic option for hyperuricemia
In the original publication of the article the presentation of Table 1 was incorrectly published. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - January 22, 2020 Category: Urology & Nephrology Source Type: research

Endoscopic treatment of symptomatic VUR disease after the renal transplantation: analysis of 49 cases
ConclusionsEndoscopic treatment of symptomatic VUR in transplanted kidney is a safe and feasible procedure. The amount of bulking agent or duration between the transplantation and diagnosis of VUR does not have any impact on the success of the treatment. However, the younger age of the patients and the female gender seem to have a positive effect on the outcome of the procedure. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - January 18, 2020 Category: Urology & Nephrology Source Type: research

Lower serum calcium and pre-onset blood pressure elevation in cerebral hemorrhage patients undergoing hemodialysis
AbstractBackgroundAsymptomatic blood pressure (BP) elevation may be associated with cerebral hemorrhage (CH); however, few studies have investigated this association. We aimed to evaluate BP elevation before CH in hemodialysis (HD) patients and elucidate its associated factors.MethodsWe reviewed HD patients treated for CH at our hospital between 2008 and 2019 (CH group). The control group comprised HD patients treated at Nagasaki Renal Center between 2011 and 2012. Data were obtained from medical records and three consecutive HD charts, made immediately before CH. HD1 was the session closest to onset, followed by HD2 and H...
Source: Clinical and Experimental Nephrology - January 14, 2020 Category: Urology & Nephrology Source Type: research

Hexapeptide derived from prothymosin alpha attenuates cisplatin-induced acute kidney injury
ConclusionTaken together, our findings indicate that P6Q can attenuate cisplatin-induced AKI and suppress the mitochondrial apoptotic pathway via Akt phosphorylation. These data suggest that P6Q has potential as a preventative drug for cisplatin-induced AKI. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - January 7, 2020 Category: Urology & Nephrology Source Type: research

Clinical outcomes after percutaneous coronary intervention in non-dialysis patients with acute coronary syndrome and advanced renal dysfunction
AbstractBackgroundData about the clinical outcomes of ACS patients with advanced renal dysfunction (estimated glomerular filtration rate  
Source: Clinical and Experimental Nephrology - January 6, 2020 Category: Urology & Nephrology Source Type: research

Resuming peritoneal dialysis after catheter removal due to complicated peritonitis
ConclusionsResuming PD after severe peritonitis requiring PC removal is feasible but a high proportion of patients do not restart PD for non-medical reasons, usually older patients with higher Charlson index. A properly structured interview would be a useful tool that could improve return to technique in these patients. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - January 4, 2020 Category: Urology & Nephrology Source Type: research

Efficacy and safety of migalastat in a Japanese population: a subgroup analysis of the ATTRACT study
ConclusionMigalastat can be used to treat Japanese patients with Fabry disease withGLA mutations amenable to migalastat according to the dosage and administration approved in other countries.Trial registration numbersClinicalTrials.gov, NCT01218659 and NCT02194985. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - December 30, 2019 Category: Urology & Nephrology Source Type: research

Clinical pharmacological study of dotinurad administered to male and female elderly or young subjects
ConclusionAge and gender had no clinically meaningful effect on the PK, PD, and safety of dotinurad.Clinical trialsClinicalTrials.gov identifier: NCT02344875. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - December 30, 2019 Category: Urology & Nephrology Source Type: research

Deterioration of presarcopenia and its risk factors following kidney transplantation
AbstractBackgroundSarcopenia is prevalent in patients with chronic kidney disease and is associated with increased mortality; however, limited data are available on whether kidney transplantation can improve muscle wasting. Therefore, the present study aimed to assess changes in body composition before and after kidney transplantation.MethodsBetween April 2015 and January 2018, 80 de novo consecutive adult patients with end-stage kidney disease who underwent kidney transplantation were prospectively enrolled. Muscle and fat masses were measured via bioelectrical impedance analysis using InBody 770 at  −&thinsp...
Source: Clinical and Experimental Nephrology - December 26, 2019 Category: Urology & Nephrology Source Type: research

Trajectories of kidney function and associated factors among community-dwelling older Japanese: a 16-year longitudinal study
ConclusionsAbout 5% of community-dwelling older adults had an eGFR  
Source: Clinical and Experimental Nephrology - December 26, 2019 Category: Urology & Nephrology Source Type: research

The effect of lanthanum carbonate on calciprotein particles in hemodialysis patients
ConclusionThe TCPP levels were significantly decreased after switching CC to LC. Non-calcium-containing phosphate binders may be preferable for lowering CPP levels. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - December 26, 2019 Category: Urology & Nephrology Source Type: research

Effect of renin –angiotensin system blockade on graft survival and cardiovascular disease in kidney transplant recipients: retrospective multicenter study in Japan
ConclusionThus, RASBs potentially reduce stroke events in KT recipients. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - December 26, 2019 Category: Urology & Nephrology Source Type: research

Open-label study of long-term administration of dotinurad in Japanese hyperuricemic patients with or without gout
ConclusionDotinurad at doses of 2 –4-mg sufficiently reduced serum uric acid levels in hyperuricemic patients with or without gout, and its efficacy and safety were verified for long-term administration.ClinicalTrials.gov Identifier: NCT03006445 (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - December 26, 2019 Category: Urology & Nephrology Source Type: research

The association between uric acid levels and renal function of CKD patients with hyperlipidemia: a sub-analysis of the ASUCA trial
AbstractBackgroundThe influence of uric acid (UA) on renal function and the significance of UA-lowering therapy are unclear. The purpose of the sub-analysis of the Assessment of Clinical Usefulness in chronic kidney disease patients with Atorvastatin (ASUCA) trial was to evaluate the influence of serum UA levels on renal function in Japanese chronic kidney disease patients with hyperlipidemia.MethodsOf 344 participants in the ASUCA trial, 279 participants whose UA levels at both baseline and 24  months were available were included. Based on UA level at baseline or mean UA level during the trial period, they were divid...
Source: Clinical and Experimental Nephrology - December 26, 2019 Category: Urology & Nephrology Source Type: research

Blood pressure control in chronic kidney disease according to underlying renal disease: the Fukushima CKD cohort
AbstractBackgroundInadequate blood pressure control is one of the important causes of chronic kidney disease (CKD), but only a limited number of reports have examined blood pressure control in Japanese patients with pre-dialysis CKD. Differences in blood pressure control due to underlying renal disease in pre-dialysis patients with CKD were investigated in the present study using the baseline data of the Fukushima CKD cohort study.MethodsThe study involved 1351 CKD patients, classified by underlying disease of primary renal disease, hypertensive nephropathy, diabetic nephropathy, other nephropathies, or unknown. Target blo...
Source: Clinical and Experimental Nephrology - December 26, 2019 Category: Urology & Nephrology Source Type: research

The relationship between liver cyst volume and QOL in Japanese ADPKD patients
ConclusionIn this cross-sectional and prospective longitudinal study, we demonstrate the relationship between liver cyst volume and QOL in ADPKD patients. We hope to establish the long-term influence on QOL in this ongoing prospective longitudinal study. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - December 26, 2019 Category: Urology & Nephrology Source Type: research

Correction to: Preventive effect of early introduction of everolimus and reduced ‑exposure tacrolimus on renal interstitial fibrosis in de novo living‑donor renal transplant recipients
In the Original publication of the article, the co-author name has been misspelled as “Yousuke Nakagawa”. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - December 26, 2019 Category: Urology & Nephrology Source Type: research

Apparent lost renal cortex due to focal pyelonephritis
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - December 26, 2019 Category: Urology & Nephrology Source Type: research

The impact of tonsillectomy combined with steroid pulse therapy in patients with advanced IgA nephropathy and impaired renal function
AbstractBackgroundPreventing progression to end-stage renal disease (ESRD) in advanced IgA nephropathy (IgAN) patients with impaired renal function remains challenging. We analyzed the efficacy of tonsillectomy combined with steroid pulse therapy (TSP).MethodsIn this retrospective analysis, IgAN patients with proteinuria  >  0.5 g/day and estimated glomerular filtration rate (eGFR) 
Source: Clinical and Experimental Nephrology - December 16, 2019 Category: Urology & Nephrology Source Type: research

Efficacy of xanthine oxidase inhibitor for chronic kidney disease patients with hyperuricemia
This study was a multi-center, open-labeled, randomized study conducted in Mie Prefecture in Japan. Patients were included if they were between 20 and 80  years old and had a serum uric acid (sUA) level ≥ 7.0 mg/dl with or without gout, estimated glomerular filtration rate (eGFR) of 15–60 ml/min/1.73 m2, and urinary protein creatinine ratio (uPCR) of 0.15 –3.5 g/gCr. Patients were randomly assigned to a Topiroxostat or Febuxostat group, and the treatment target for the sUA level was 
Source: Clinical and Experimental Nephrology - December 16, 2019 Category: Urology & Nephrology Source Type: research

Effects of mild and moderate renal dysfunction on pharmacokinetics, pharmacodynamics, and safety of dotinurad: a novel selective urate reabsorption inhibitor
AbstractBackgroundDotinurad, a novel selective urate reabsorption inhibitor, exerts a serum uric acid-lowering effect by selectively inhibiting urate transporter 1 (URAT1) in patients with hyperuricemia. It is generally known that the progression of renal dysfunction is associated with a reduction in the serum uric acid-lowering effects of uricosuric drugs. We, therefore, investigated the pharmacokinetics (PK), pharmacodynamics (PD), and safety of dotinurad in subjects with renal dysfunction.MethodsThis was a parallel-group, open-label, single-dose clinical pharmacology study. Dotinurad (1  mg) was administered once, ...
Source: Clinical and Experimental Nephrology - December 10, 2019 Category: Urology & Nephrology Source Type: research

Changes in double-strand DNA breaks predict delayed graft function (DGF) in Japanese renal allograft recipients
ConclusionThe combination of donor sCr and Δγ-H2AX from 0 to 1 h after reperfusion may predict severe DGF and PNF in the early phase. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - December 7, 2019 Category: Urology & Nephrology Source Type: research

Role of A20/TNFAIP3 deficiency in lupus nephritis in MRL/lpr mice
ConclusionThus, the results of the present study suggest that A20 regulates UCH-L1 expression via the NF- κB signaling pathway and A20 deficiency might play an important role in LN pathogenesis. Therefore, the A20 protein may serve as a promising therapeutic target for LN. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - December 7, 2019 Category: Urology & Nephrology Source Type: research

Clinical efficacy and safety of dotinurad, a novel selective urate reabsorption inhibitor, in Japanese hyperuricemic patients with or without gout: randomized, multicenter, double-blind, placebo-controlled, parallel-group, confirmatory phase 2 study
ConclusionThe serum uric acid lowering effect and safety of dotinurad were confirmed in hyperuricemic patients with or without gout.ClinicalTrials.gov IdentifierNCT02416167 (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - December 3, 2019 Category: Urology & Nephrology Source Type: research

Preventive effect of early introduction of everolimus and reduced-exposure tacrolimus on renal interstitial fibrosis in de novo living-donor renal transplant recipients
AbstractBackgroundTo improve the long-term outcomes following renal transplantation, prevention of renal-allograft interstitial fibrosis (IF), mainly due to calcineurin inhibitors, is an important therapeutic target. Everolimus (EVR) was reported to have antifibrotic effects. We aimed to investigate the safety, efficacy, and IF of our modified immunosuppressive regimen, which includes early introduction of EVR and reduced-exposure tacrolimus (Tac) (EVR group), and compare it with the standard-exposure tacrolimus-based regimen (Tac group) in de novo living-donor renal recipients.MethodsIn this retrospective, single-center c...
Source: Clinical and Experimental Nephrology - December 2, 2019 Category: Urology & Nephrology Source Type: research

Vasculitis with nonpalpable purpura resembling purpura fulminans
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - November 27, 2019 Category: Urology & Nephrology Source Type: research

Serum N -glycan profiling can predict biopsy-proven graft rejection after living kidney transplantation
ConclusionEvaluation of serumN-glycosylation profiles can identify recipients who are prone to rejection. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - November 25, 2019 Category: Urology & Nephrology Source Type: research

Utility and safety of early allograft biopsy in adult deceased donor kidney transplant recipients
ConclusionsIn low-immunological risk recipients treated with induction and calcineurin inhibitors maintenance, protocol biopsies obtained within 2  weeks of surgery to rule out rejection during DGF do not necessarily offer a favourable balance between risks and benefits. In these patients, a tailored approach may minimize complications thus optimizing results. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - November 25, 2019 Category: Urology & Nephrology Source Type: research

Urinary podocyte mRNA is a potent biomarker of anti-neutrophil cytoplasmic antibody-associated glomerulonephritis
ConclusionsU-PodCR, U-PNR or a combination of these parameters might serve as a non-invasive potential biomarker in patients with ANCA-GN to predict the percent of crescent formation and renal prognosis. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - November 25, 2019 Category: Urology & Nephrology Source Type: research

Relationship between serum inorganic phosphorus levels and cognitive decline over 2  years in older adults with pre-dialysis chronic kidney disease
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - November 25, 2019 Category: Urology & Nephrology Source Type: research

Dotinurad: a clinical pharmacokinetic study of a novel, selective urate reabsorption inhibitor in subjects with hepatic impairment
ConclusionThe study revealed no clinically meaningful influence of hepatic impairment on the PK, PD, or safety of dotinurad. These findings indicate possibility that dotinurad can be used without dose adjustment in patients with hepatic impairment. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - November 23, 2019 Category: Urology & Nephrology Source Type: research

Clinical efficacy and safety of dotinurad, a novel selective urate reabsorption inhibitor, in Japanese hyperuricemic patients with or without gout: an exploratory, randomized, multicenter, double-blind, placebo-controlled, parallel-group early phase 2 study
ConclusionDotinurad has a substantial serum uric acid lowering effect in patients with hyperuricemia. No serious adverse event was found.ClinicalTrials.gov IdentifierNCT02344862 (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - November 21, 2019 Category: Urology & Nephrology Source Type: research

Dotinurad: a novel selective urate reabsorption inhibitor as a future therapeutic option for hyperuricemia
AbstractGout is a chronic inflammatory disease caused by precipitation of urate crystals in the joints, kidneys, and urinary tract. Independent of urate deposition disorders, recent studies have shown a positive association between circulating uric acid (UA) levels and cardiovascular (CV) diseases. These results indicate that UA is a precipitating factor of both gout and the progression of CV diseases, including hypertension and/or chronic kidney disease (CKD). A large body of evidence has shown that UA-lowering therapies are effective in preventing the progression of hypertension/CKD and that a causal relationship exists ...
Source: Clinical and Experimental Nephrology - November 21, 2019 Category: Urology & Nephrology Source Type: research

Diagnostic accuracy of urine dipstick for proteinuria category in Japanese workers
We examined the dipstick ’s accuracy in assessing the proteinuria levels among Japanese workers.MethodsWe assessed subjects aged  ≥ 18 years who had a health checkup at the University of Tokyo in 2016 or 2017 (n = 5383). Proteinuria was stratified by urine protein-to-creatinine ratio (PCR): A1, 
Source: Clinical and Experimental Nephrology - November 16, 2019 Category: Urology & Nephrology Source Type: research

Predictive performance of lipid accumulation product and visceral adiposity index for renal function decline in non-diabetic adults, an 8.6-year follow-up
AbstractBackgroundLipid accumulation product (LAP) and visceral adiposity index (VAI) are surrogates for visceral adiposity dysfunction. Our aim was to evaluate potential association of these two indices with the incidence of renal function decline.MethodsWe included 6693 non-diabetic adults age  ≥ 18 years, with estimated glomerular filtration rate (eGFR) ≥ 60 ml/min/1.73 m2, from the Tehran Lipid and Glucose Study 2002 –2005 survey. Natural logarithmic transformation (Ln) was applied for LAP and VAI measures. The incidence of renal function decline, defined as eGFR 
Source: Clinical and Experimental Nephrology - November 16, 2019 Category: Urology & Nephrology Source Type: research

The effect for hyperuricemia inpatient of uric acid overproduction type or in combination with topiroxostat on the pharmacokinetics, pharmacodynamics and safety of dotinurad, a selective urate reabsorption inhibitor
ConclusionIn inpatients, differences in hyperuricemic type did not significantly influence the pharmacokinetics, pharmacodynamics, and safety of dotinurad. Moreover, in “overproduction type”, the coadministration of dotinurad and topiroxostat had an add-on serum uric acid lowering effect and suppressed urinary uric acid excretion.Trial registrationClinicalTrials.gov Identifier: NCT02837198. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - November 16, 2019 Category: Urology & Nephrology Source Type: research

Intensive uric acid-lowering therapy in CKD patients: the protocol for a randomized controlled trial
AbstractBackgroundHyperuricemia would be a risk factor for the development/progression of CKD. However, several studies showed U-shape association between serum uric acid level and renal impairment, suggesting that hypouricemia was rather associated with renal dysfunction. Perhaps, there is the optimal target level of serum UA for renal function.MethodsThe Target-UA study is a multicenter randomized controlled trial. Eligible CKD patients (eGFR  ≥ 30, 
Source: Clinical and Experimental Nephrology - November 15, 2019 Category: Urology & Nephrology Source Type: research

Optimal bacterial colony counts for the diagnosis of upper urinary tract infections in infants
AbstractBackgroundThere are no consensus criteria for diagnosing upper urinary tract infections (UTI). Therefore, we conducted a study to assess whether bacterial colony counts of  ≥ 103 CFU/ml are optimal for diagnosing upper UTIs among infants.MethodsThis retrospective observational study included 673 patients (
Source: Clinical and Experimental Nephrology - November 12, 2019 Category: Urology & Nephrology Source Type: research

Guideline on the use of iodinated contrast media in patients with kidney disease 2018
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - November 11, 2019 Category: Urology & Nephrology Source Type: research