Manual compression and reflex syncope in native renal biopsy
ConclusionManual compression and abdominal bandage significantly increased the frequency of reflex syncope during native PRB. It is necessary to consider the potential benefit and risk of compression maneuvers for each patient undergoing this procedure. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - September 17, 2018 Category: Urology & Nephrology Source Type: research

Initial treatment with pulse methylprednisolone followed by short-term prednisolone and tonsillectomy for childhood IgA nephropathy
ConclusionsAs an initial treatment, IVMP followed by short-term PSL and tonsillectomy appears to be effective for treating childhood IgAN. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - September 17, 2018 Category: Urology & Nephrology Source Type: research

Hypertension and its severity in children with steroid sensitive nephrotic syndrome during remission
ConclusionThere is high incidence of hypertension in NS children during remission. Though significant positive correlation was found with positive family history of hypertension and deranged lipid profile highlighting possibility of essential hypertension in them, there is need for close active monitoring and management of hypertension in them as untreated cases may have significant target organ damage. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - September 17, 2018 Category: Urology & Nephrology Source Type: research

Practice pattern of physician ’s directions of exercise restriction in patients with chronic kidney disease: results from the Chronic Kidney Disease Japan Cohort study
ConclusionsThe findings from this study suggested the factors related with prescribing exercise restrictions. Further studies examining which patients with CKD need direction of exercise restrictions are needed. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - September 17, 2018 Category: Urology & Nephrology Source Type: research

Pre-operative and post-operative estimated glomerular filtration rate in Japanese patients with urological malignancies
We examined the relationship between creatinine clearance-based measured GFR (mGFR) versus estimated GFR (eGFR) calculated by 3 popular equations, 4-variable Modification of Diet in Renal Disease equation adjusted by Japanese correction coefficient (cmMDRD), 3-variable MDRD equation for Japanese population (eGFRcreat), and Chronic Kidney Disease-Epidemiology Collaboration equation adjusted by Japanese correction coefficient (cmCKD-EPI) in Japanese patients who had undergone RN or RNU due to renal cell carcinoma or upper tract urothelial carcinoma before and after surgery.ResultsAmong the 3 equations examined, eGFRcreat was...
Source: Clinical and Experimental Nephrology - September 17, 2018 Category: Urology & Nephrology Source Type: research

Butyrylcholinesterase level as an independent factor of erythropoiesis-stimulating agent resistance in patients on maintenance hemodialysis: a single-center cross-sectional study
AbstractBackgroundErythropoiesis-stimulating agent (ESA) responsiveness is related to the nutritional status of patients on hemodialysis (HD). Serum butyrylcholinesterase (BChE), an alpha-glycoprotein, may decrease in case of malnutrition. We investigated whether BChE was independently related to ESA resistance in patients on HD.MethodsThe laboratory data and ESA resistance index (ERI), defined as ESA dosage per week divided by dry weight and hemoglobin, were investigated in 215 patients on HD between July and September 2017. Malnutrition was defined as Geriatric Nutritional Risk Index (GNRI) of
Source: Clinical and Experimental Nephrology - September 17, 2018 Category: Urology & Nephrology Source Type: research

Visit-to-visit blood pressure variability in children and adolescents with renal disease
In this study, we examined whether visit-to-visit variability (VVV) could predict WCH and whether VVV correlated with eGFR, eGFR slope, and albuminuria/proteinuria in children and adolescents with renal diseases.MethodsVVV was determined as average real variability of office BP measurements between visits, and 24-h BPV as the standard deviation of 24-h ambulatory BP. In 35 renal patients (25 boys and 10 girls, 7 –18 years of age), divided into normotension (NT), WCH, and hypertension (HTN), the relationships between VVV and 24-h BPV and VVV in each BP category were studied. In separate 48 renal patients (24 boys...
Source: Clinical and Experimental Nephrology - September 17, 2018 Category: Urology & Nephrology Source Type: research

The size of the renal artery orifice contributes to laterality of acute renal infarction
ConclusionThe size of the renal artery orifice may be a factor that contributes to the laterality of ARI. Assessment of anatomical features is important when considering the laterality of the disease. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - September 17, 2018 Category: Urology & Nephrology Source Type: research

Association between exercise intensity and renal blood flow evaluated using ultrasound echo
This study examined variations in RBF at different exercise intensities using ultrasound echo.MethodsEight healthy men with normal renal function (eGFRcys 114  ± 19 mL/min/1.73 m2) participated in this study. Using a bicycle ergometer, participants underwent an incremental exercise test using a ramp protocol (20  W/min) until exhaustion in Study 1 and the lactate acid breaking point (LaBP) was calculated. Participants underwent a multi-stage test at exercise intensities of 60, 80, 100, 120, and 140% LaBP in Study 2. RBF was measured by ultrasound echo at rest and 5 min after exercis...
Source: Clinical and Experimental Nephrology - September 17, 2018 Category: Urology & Nephrology Source Type: research

Defective renal autoregulation in the chronic bile duct ligation model of liver failure
ConclusionTubuloglomerular feedback (TGF) responses were significantly attenuated in BDL rats, especially in the subnormal flow range. Impairment of renal blood flow autoregulation, to some extent mediated by reduced TGF-mediated vasodilatation, may contribute to the renal vascular constrictor state in liver cirrhosis by preventing the full dilatory response to the blood pressure reduction. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - September 17, 2018 Category: Urology & Nephrology Source Type: research

Early renoprotection by anemia correction
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - September 17, 2018 Category: Urology & Nephrology Source Type: research

Scanning electron microscopy of polycystic liver disease
AbstractResected specimens of PCLD by laparoscopic fenestration surgery were evaluated by scanning electron microscopy. Epithelium lining the largest cyst (26 cm in size) showed prominent villous proliferation with positivity of Ki-67, while the epithelium of the small cyst (3 cm in size) showed slight proliferation (smooth) with small positivity of Ki-67. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - September 17, 2018 Category: Urology & Nephrology Source Type: research

Influence of chronic kidney disease and worsening renal function on clinical outcomes in patients undergoing primary percutaneous coronary intervention
AbstractBackgroundThe combined influence of CKD and worsening renal function (WRF) on clinical outcomes in patients undergoing primary percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI) has not been fully understood.MethodsWe analyzed 443 patients diagnosed with AMI who underwent primary PCI. Based on their estimated glomerular filtration rate (eGFR), they were classified into two groups: a high eGFR group (eGFR  ≥ 45 mL/min/1.73 m2,n = 381) and a low eGFR group (eGFR 
Source: Clinical and Experimental Nephrology - September 14, 2018 Category: Urology & Nephrology Source Type: research

Risk factors for kidney disease among HIV-1 positive persons in the methadone program
AbstractBackgroundKidney injury is a serious comorbidity among HIV-infected patients. Intravenous drug use is listed as one of the risk factors for impaired renal function; however, this group is rarely assessed for specific renal-related risks.MethodsPatients attending methadone program from 1994 to 2015 were included in the study. Data collected included demographic data, laboratory tests, antiretroviral treatment history, methadone dosing and drug abstinence. Patients ’ drug abstinence was checked monthly on personnel demand. We have evaluated two study outcomes: (1) having at least one or (2) three eGFR 
Source: Clinical and Experimental Nephrology - September 14, 2018 Category: Urology & Nephrology Source Type: research

Biological variation of procalcitonin levels in hemodialysis patients
ConclusionsThe PCT level was significantly higher in stable HD patients without manifest bacterial infection. CVb was more variable than CVi in HD patients, which indicates that relative change is more important than absolute PCT levels for diagnosing bacterial infection, and doubling or more of the baseline PCT level may imply the presence of a bacterial infection in HD patients. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - September 8, 2018 Category: Urology & Nephrology Source Type: research

Clinical impact of abdominal fat distribution measured by 3-D computed tomography volumetry on post-transplant renal function in recipients after living kidney transplantation: a retrospective study
AbstractBackgroundExcessive visceral fat may decrease renal function because of metabolic derangements. The aim of this study was to evaluate the impact of abdominal fat distribution on renal function of recipients after kidney transplantation using the visceral adipose tissue (VAT)/subcutaneous adipose tissue (SAT) ratio.MethodsSeventy-nine patients underwent living kidney transplantation from 2009 to 2017. Patients without a correct measurement of VAT and SAT, follow-up of
Source: Clinical and Experimental Nephrology - September 6, 2018 Category: Urology & Nephrology Source Type: research

Safety and effectiveness of long-term use of darbepoetin alfa in non-dialysis patients with chronic kidney disease: a post-marketing surveillance study in Japan
AbstractBackgroundThis post-marketing surveillance (PMS) study evaluated the safety and effectiveness of long-term darbepoetin alfa (darbepoetin) for the treatment of renal anemia in Japanese non-dialysis chronic kidney disease patients.MethodsPatients were treated with darbepoetin and followed up for 3  years. Adverse events (AEs), adverse drug reactions (ADRs), hemoglobin (Hb) levels, and renal function were assessed. Patients were stratified by Hb level at the time of occurrence of cardiovascular-related AEs. Statistical analyses were performed to explore factors affecting the occurrence of AEs , cardiovascular-rel...
Source: Clinical and Experimental Nephrology - September 4, 2018 Category: Urology & Nephrology Source Type: research

Clinical epidemiology of infectious disease among patients with chronic kidney disease
AbstractInfectious disease is recognized as an important complication among patients with end-stage renal disease, contributing to excess morbidity and health care costs. However, recent epidemiological studies have revealed that even mild to moderate stages of chronic kidney disease (CKD) substantially increase risk of infection. Regarding underlying mechanisms, evidence suggests various aspects of altered immune response in patients with CKD including impaired function of T cells, B cells and neutrophil. Multiple conditions surrounding CKD, such as older age, diabetes, and cardiovascular disease are important contributor...
Source: Clinical and Experimental Nephrology - September 3, 2018 Category: Urology & Nephrology Source Type: research

Symmetric nephromegaly
We report a lady with bilateral symmetrical xanthogranulomatous pyelonephritis (XPGN) presented with acute kidney injury and sepsis, in which both CT and MRI mimicked an infiltrative disease, except that the infiltration was not very homogenous. Eventually, the pathological diagnosis turned out to be XPGN. Most XPGN were unilateral, and there have been a few publications of bilateral involvement. Moreover, this case lacked typical manifestations, such as renal calculus, contracted renal pelvis, or obstructive nephropathy. This image reminds us that bilateral renal infiltrative disease could not completely exclude the possi...
Source: Clinical and Experimental Nephrology - September 3, 2018 Category: Urology & Nephrology Source Type: research

Association between renal outcome and the number of steroid pulse therapies after tonsillectomy in patients with IgA nephropathy
ConclusionsFor treatment of IgAN, SP administered three times after tonsillectomy was associated with better renal prognosis compared with SP administered only once or twice. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - September 3, 2018 Category: Urology & Nephrology Source Type: research

Early postoperative change in serum creatinine predicts acute kidney injury after cardiothoracic surgery: a retrospective cohort study
AbstractBackgroundAcute kidney injury (AKI) is one of the most severe complications after cardiothoracic surgery (CTS). However, diagnosis of AKI by elevation of serum creatinine (SCr) misses a critical time period for prevention and treatment of AKI. We have observed that patients who develop AKI show a smaller SCr decrease after CTS than those without AKI. Hence, we hypothesized that the magnitude of the SCr change ( ΔSCr) measured early after CTS can predict subsequent AKI.MethodsWe conducted a retrospective analysis from January 2014 to December 2016 to examine the association of ΔSCr with AKI. ΔSCr w...
Source: Clinical and Experimental Nephrology - August 29, 2018 Category: Urology & Nephrology Source Type: research

Pharmacodynamics of evocalcet for secondary hyperparathyroidism in Japanese hemodialysis patients
ConclusionMultiple doses of evocalcet reduced intact PTH levels with a concomitant decrease in serum calcium levels. Evocalcet was well tolerated in SHPT patients receiving hemodialysis. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - August 29, 2018 Category: Urology & Nephrology Source Type: research

The efficacy of exercise training in kidney transplant recipients: a meta-analysis and systematic review
ConclusionsExercise training for kidney transplant recipients significantly improved exercise tolerability and QOL, but a significant improvement was not obtained with respect to allograft kidney function. Evaluation of patient survival rates and the harm associated with exercise training has not been reported, therefore, future studies are needed to resolve these issues. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - August 24, 2018 Category: Urology & Nephrology Source Type: research

Association between serum Na –Cl level and renal function decline in chronic kidney disease: results from the chronic kidney disease Japan cohort (CKD-JAC) study
This study aimed to evaluate serum Na–Cl level as a risk factor for renal function decline among patients who participated in the chronic kidney disease Japan cohort (CKD-JAC) study.MethodsThe association between low Na –Cl concentration (
Source: Clinical and Experimental Nephrology - August 24, 2018 Category: Urology & Nephrology Source Type: research

Reduction of low molecular weight proteins under continuous renal replacement therapy in acute renal failure
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - August 24, 2018 Category: Urology & Nephrology Source Type: research

Correction to: Validation of estimated glomerular filtration rate equations for Japanese children
In the original publication, the author name was published incorrectly as “Riku Hamda”. The corrected name is given in this Correction. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - August 24, 2018 Category: Urology & Nephrology Source Type: research

Low serum complement 3 level is associated with severe ANCA-associated vasculitis at diagnosis
AbstractObjectivesWe investigated whether low serum C3 level can cross-sectionally estimate severe antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in immunosuppressive drug-na ïve patients at diagnosis.MethodsWe retrospectively reviewed the medical records of 139 patients with AAV, who were first classified as AAV at Severance Hospital. We obtained clinical and laboratory data including serum complement 3 (C3) level and calculated Birmingham vasculitis activity score (BVAS) at diagnosis. We stratified AAV patients into three groups according to the tertile of BVAS and defined the lower limit of ...
Source: Clinical and Experimental Nephrology - August 23, 2018 Category: Urology & Nephrology Source Type: research

Left-sided inferior vena cava with nutcracker syndrome
We report an 11-year-old boy with hematuria and left lower back pain due to compression of the left-sided IVC between the aorta and the superior mesenteric artery. Ultrasonography and magnetic resonance imaging clearly revealed this anatomic anomaly. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - August 23, 2018 Category: Urology & Nephrology Source Type: research

A review of clinical characteristics and genetic backgrounds in Alport syndrome
AbstractAlport syndrome (AS) is a progressive hereditary renal disease that is characterized by sensorineural hearing loss and ocular abnormalities. It is divided into three modes of inheritance, namely, X-linked Alport syndrome (XLAS), autosomal recessive AS (ARAS), and autosomal dominant AS (ADAS). XLAS is caused by pathogenic variants inCOL4A5, while ADAS and ARAS are caused by those inCOL4A3/COL4A4. Diagnosis is conventionally made pathologically, but recent advances in comprehensive genetic analysis have enabled genetic testing to be performed for the diagnosis of AS as first-line diagnosis. Because of these advances,...
Source: Clinical and Experimental Nephrology - August 20, 2018 Category: Urology & Nephrology Source Type: research

GFR estimation in lenalidomide treatment of multiple myeloma patients: a prospective cohort study
ConclusionsIn our multiple myeloma patient cohort, CKD-EPI and MDRD led to similar CKD staging with minor differences in lenalidomide dosage assignment. Consistent with previous studies, eGFR improved under lenalidomide treatment. To standardize GFR estimation in myeloma patients, we suggest using the CKD-EPI equation. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - August 20, 2018 Category: Urology & Nephrology Source Type: research

Positive effects of single-daily high-dose mizoribine therapy after cyclophosphamide in young children with steroid-dependent nephrotic syndrome
AbstractBackgroundMizoribine (MZR) therapy after cyclophosphamide (CPM) therapy may be an attractive option in patients with steroid-dependent nephrotic syndrome (SDNS) for the purpose of maintaining remission. This is because CPM is administered only once due to its severe side effects such as gonadal toxicity. However, the long-term prognosis after the treatment regimen remains unknown.MethodsWe retrospectively analyzed the clinical course (median follow-up, 5.9  years) of 54 young children with SDNS (43 boys; age   12 months for maintaining remission after CPM therapy (N = 36), and ...
Source: Clinical and Experimental Nephrology - August 18, 2018 Category: Urology & Nephrology Source Type: research

Breath analysis as promising indicator of hemodialysis efficiency
AbstractBackgroundThe measurement of trimethylamine and isoprene in exhaled breath collected from dialysed patients indicates the changes in concentration of both compounds during dialysis. The aim of the presented study was to confirm diagnostic usefulness of TMA and isoprene detected in breath, as potential biomarkers of hemodialysis efficiency.MethodsThe samples of exhaled breath were collected from 22 dialyzed patients (9 women, 13 men) before and after hemodialysis (HD). All analyses were carried out using a gas chromatograph equipped with a mass spectrometer. Thermal desorption was used as breath sample enrichment me...
Source: Clinical and Experimental Nephrology - August 18, 2018 Category: Urology & Nephrology Source Type: research

Prevalence and predictors of early hypercalcemia after kidney transplantation: a nested case –control study within a cohort of 100 patients
AbstractBackgroundHypercalcemia (HC) after kidney transplantation (KTx) can deteriorate both graft and patient survival. However, HC as a clinical condition and its clinical significance after KTx remain unknown. We evaluated the prevalence and risk factors of early HC after KTx.MethodsWe performed a nested case –control study using a cohort of 100 KTx patients. KTx patients were divided into the HC and normocalcemia (NC) groups based on the baseline serum-corrected calcium (cCa) levels (≥ 10.5 and
Source: Clinical and Experimental Nephrology - August 18, 2018 Category: Urology & Nephrology Source Type: research

Therapeutic efficacy of rituximab for the management of adult-onset steroid-dependent nephrotic syndrome: a retrospective study
AbstractBackgroundRecent reports have described the efficacy of rituximab in treating steroid-dependent nephrotic syndrome (SDNS) in pediatric patients. However, few reports describe data regarding adult-onset SDNS. We investigated the efficacy of rituximab for the management of adult-onset SDNS.MethodsWe performed a retrospective cohort study investigating eight patients with adult-onset SDNS who were treated with rituximab. Clinical data were obtained at the initiation of rituximab therapy. The primary outcomes evaluated were successful suppression of relapses and CD19+ cells after rituximab treatment. The corticosteroid...
Source: Clinical and Experimental Nephrology - August 18, 2018 Category: Urology & Nephrology Source Type: research

Correction to: Risk factors for increased left ventricular hypertrophy in patients with chronic kidney disease: findings from the CKD-JAC study
In the original publication, there were several errors identified after online publication. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - August 9, 2018 Category: Urology & Nephrology Source Type: research

Effect of ferric citrate hydrate on FGF23 and PTH levels in patients with non-dialysis-dependent chronic kidney disease with normophosphatemia and iron deficiency
AbstractBackgroundIn patients with normophosphatemia with chronic kidney disease (CKD), fibroblast growth factor 23 (FGF23) and parathyroid hormone (PTH) increase urinary phosphate excretion while maintaining serum phosphate within the normal range. Recent reports have shown that, in this stage, phosphate binders do not decrease serum FGF23 and PTH levels. Iron deficiency promotes transcription of FGF23 and iron-supplementation for iron deficiency decreases serum FGF23 levels. We hypothesized that ferric citrate hydrate, an iron-based phosphate binder, will decrease serum FGF23 levels in patients with non-dialysis-dependen...
Source: Clinical and Experimental Nephrology - July 7, 2018 Category: Urology & Nephrology Source Type: research

Rationale, design, and characteristics of a trial to evaluate the new phosphate iron-based binder sucroferric oxyhydroxide in dialysis patients with the goal of advancing the practice of E.B.M. (EPISODE)
AbstractBackgroundIn dialysis patients, mortality risk due to cardiovascular diseases is remarkably high and prognosis is poor; coronary artery calcification is considered one of the major contributing factors. It is known that hyperphosphatemia is associated with coronary artery calcification. Therefore, controlling serum phosphate level and thereby mitigating vascular calcification could improve the poor prognosis of dialysis patients. However, the optimal phosphate level in dialysis patients remains unknown; hence, this study was planned to compare the effects of two types of non-calcium-based phosphate binders, and exa...
Source: Clinical and Experimental Nephrology - July 7, 2018 Category: Urology & Nephrology Source Type: research

Change in the quality of life of caregivers of pediatric department patients undergoing kidney transplantation: a single-center prospective study
ConclusionDialysis of children before KTx was a particularly larger burden for caregivers. The child ’s comorbidities and social adaptation problems might be focused after KTx, we need to evaluate for more long-term QOL of caregivers. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - July 6, 2018 Category: Urology & Nephrology Source Type: research

Differences in peritoneal solute transport rates in peritoneal dialysis
ConclusionsD/Ps of some molecules did not correlate withD/P creatinine. Factors other than molecular weight, such as charge and protein binding rate, are involved in peritoneal transport rates. Metabolomic analysis appears useful to analyze small molecular uremic toxins, which could accumulate in PD patients, and the status of peritoneal membrane transport for each molecule. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - July 2, 2018 Category: Urology & Nephrology Source Type: research

22-oxacalcitriol prevents acute kidney injury via inhibition of apoptosis and enhancement of autophagy
ConclusionThese results demonstrate that treatment with OCT has a renoprotective effect in ischemic AKI, possibly by suppressing cell loss. Changes in the expression of IFN-g and NHE-1 could partially link OCT to the cell survival-promoted effects. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - July 2, 2018 Category: Urology & Nephrology Source Type: research

Characterising skeletal muscle haemoglobin saturation during exercise using near-infrared spectroscopy in chronic kidney disease
ConclusionsUsing NIRS, we have determined for the first time in CKD, that favourable SMO2% kinetics (slower deoxygenation rate, quicker recovery) are associated with greater exercise capacity. These dysfunctional kinetics may indicate reduced mitochondria capacity to perform oxidative phosphorylation —a process essential for carrying out even simple activities of daily living. Accordingly, NIRS may provide a simple, low cost, and non-invasive means to evaluate muscle O2 kinetics in CKD. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - June 30, 2018 Category: Urology & Nephrology Source Type: research

Calcium-sensing receptor (CaSR) modulates vacuolar H + -ATPase activity in a cell model of proximal tubule
ConclusionCaSR stimulation induces an increase in the vacuolar H+-ATPase activity of OKP cells, an effect that involves an increase in [Ca2+]i and require phospholipase C activity. The consequent decrease in intratubular pH could lead to increase ionization of luminal calcium, potentially enhancing its reabsorption in distal tubule segments and reducing the formation of calcium phosphate stones. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - June 30, 2018 Category: Urology & Nephrology Source Type: research

Safety and effectiveness of eculizumab for adult patients with atypical hemolytic –uremic syndrome in Japan: interim analysis of post-marketing surveillance
ConclusionsThis interim analysis confirmed the acceptable safety profile and effectiveness of eculizumab for Japanese adult aHUS patients in real-world settings. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - June 29, 2018 Category: Urology & Nephrology Source Type: research

Risk factors for increased left ventricular hypertrophy in patients with chronic kidney disease: findings from the CKD-JAC study
ConclusionThe cross-sectional baseline data from the CKD-JAC study shed light on the association between LVH and risk factors in patients with decreased renal function. Further longitudinal analyses of the CKD-JAC cohort are needed to evaluate the prognostic value of LVH in CKD patients. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - June 27, 2018 Category: Urology & Nephrology Source Type: research

Relationship between abdominal adiposity and incident chronic kidney disease in young- to middle-aged working men: a retrospective cohort study
AbstractBackgroundObesity is a risk factor for the development of chronic kidney disease (CKD). However, it remains to be fully examined whether fatness is more useful in predicting incident CKD. We aimed this study to determine the association of body fat, body mass index and waist circumference (WC) with subsequent changes in estimated glomerular filtration rate (eGFR) and incident CKD in young- to middle-aged working men.MethodsWe analyzed data from annual health check-up in male workers aged from 20 to 60  years with basal eGFR of 60–90 mL/min/1.73 m2. Cut-off values of parameters and odds ratio (O...
Source: Clinical and Experimental Nephrology - June 27, 2018 Category: Urology & Nephrology Source Type: research

Hyponatremia and mortality among very elderly residents in a geriatric health service facility
This study aimed to examine the prognostic value of hyponatremia among elderly residents in a geriatric facility.MethodsWe retrospectively examined the association between serum sodium levels and mortality among 118 residents (82% female, mean age 85.5  years) in a single geriatric health service facility. We defined hyponatremia as Na 
Source: Clinical and Experimental Nephrology - June 27, 2018 Category: Urology & Nephrology Source Type: research

Acute phosphate nephropathy leading to graft failure
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - June 27, 2018 Category: Urology & Nephrology Source Type: research

Trace proteinuria by dipstick screening is associated with metabolic syndrome, hypertension, and diabetes
ConclusionSubjects with dipstick-determined trace proteinuria showed intermediate risk of having MetS, hypertension, and diabetes between negative and positive proteinuria in any eGFR category in a large general population. Thus, MetS components should be checked for subjects with trace proteinuria even in those with normal eGFR for the early prevention of cardiovascular diseases. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - June 22, 2018 Category: Urology & Nephrology Source Type: research

Comparison of the effects of tolvaptan and furosemide on renal water and sodium excretion in patients with heart failure and advanced chronic kidney disease: a subanalysis of the K-STAR study
ConclusionsAdd-on TLV may increase both renal water and Na excretion in CHF patients with advanced CKD to a greater degree than increased FUR. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - June 22, 2018 Category: Urology & Nephrology Source Type: research

Biocompatibility of a new PD solution for Japan, Reguneal ™, measured as in vitro proliferation of fibroblasts
ConclusionOur study suggests that Reguneal ™ is a biocompatible PDF. The results of our study also highlight that dextrose and GDPs are important for biocompatibility, but alone are not a complete surrogate. The results of our study need to be confirmed in other tissue culture models, and should lead to further research on determinants of biocompatibility and the effect of such PDFs on clinical outcomes. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - June 20, 2018 Category: Urology & Nephrology Source Type: research