The effects of xanthine oxidase inhibitor in patients with chronic heart failure complicated with hyperuricemia: a prospective randomized controlled clinical trial of topiroxostat vs allopurinol —study protocol
ConclusionsThe Excited-UA study would provide novel evidence for the clinical relevancy of xanthine oxidoreductase inhibitor treatment in patients with chronic heart failure and hyperuricemia. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - June 18, 2018 Category: Urology & Nephrology Source Type: research

Effect of essential amino acid кetoanalogues and protein restriction diet on morphogenetic proteins (FGF-23 and Кlotho) in 3b–4 stages chronic кidney disease patients: a randomized pilot study
ConclusionLPD  + KA provides support for nutrition status and contributes to more efficient correction of FGF-23 and Klotho abnormalities that may result in cardiovascular calcification and cardiac remodeling decreasing in CKD. At the same time, a prolonged LPD alone may lead to malnutrition. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - June 11, 2018 Category: Urology & Nephrology Source Type: research

Long-term outcomes in acute kidney injury patients who underwent continuous renal replacement therapy: a single-center experience
AbstractIntroductionAcute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT) is the most severe form of AKI associated with poor short- and long-term patient outcomes. The aim of this study was to evaluate the variables associated with long-term patient survival in our clinic.MethodsThis was a single-center retrospective study with AKI survivors who received CRRT from March 2011 to February 2015. During the study period, all consecutive AKI survivors who underwent CRRT were included. Patients on maintenance dialysis prior to CRRT were excluded. Data were collected by reviewing the patients ’ me...
Source: Clinical and Experimental Nephrology - June 11, 2018 Category: Urology & Nephrology Source Type: research

Effect of peritoneal dialysis vs. haemodialysis on respiratory mechanics in acute kidney injury patients
ConclusionAKI patients undergoing IMV and HD or PD had improvement in the mechanical ventilation and oxygenation, with no difference between the two groups. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - June 11, 2018 Category: Urology & Nephrology Source Type: research

The first year results of mizoribine/tacrolimus-based multitarget treatment for consecutive patients with lupus nephritis
ConclusionsOur results suggest that multitarget therapy using mizoribine opposed to MMF is highly safe and effective through 12  months. The therapy may enable faster dose reduction of concomitant glucocorticoids. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - June 9, 2018 Category: Urology & Nephrology Source Type: research

GFR-estimation by serum creatinine during glucocorticosteroid therapy
ConclusionGCS use had no significant effect on serum creatinine as a marker for kidney function in a mixed population of renal outpatient clinic children. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - June 9, 2018 Category: Urology & Nephrology Source Type: research

Is medium dose of cyclosporine A effective in treatment of children with steroid-dependent nephrotic syndrome with reduction in corticosteroids dose consumption?
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - June 9, 2018 Category: Urology & Nephrology Source Type: research

Impact of high mortality in incident dialysis patients due to hypertensive nephrosclerosis: a multicenter prospective cohort study in Aichi, Japan
ConclusionsThe present study was Japan ’s first large-scale prospective cohort to demonstrate that HTN is the second most common cause of ESRD. In addition, the prognosis of patients with HTN was as poor as that of patients with DN. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - June 7, 2018 Category: Urology & Nephrology Source Type: research

Bevacizumab-induced thrombotic microangiopathy and nephrotic syndrome
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - June 7, 2018 Category: Urology & Nephrology Source Type: research

Dipstick proteinuria and all-cause mortality among the general population
ConclusionDipstick proteinuria is an independent predictor of death among Japanese community-based screening participants. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - June 5, 2018 Category: Urology & Nephrology Source Type: research

Decreased KLHL3 expression is involved in the pathogenesis of pseudohypoaldosteronism type II caused by cullin 3 mutation in vivo
ConclusionKLHL3 expression was decreased in CUL3WT/ Δex9 mice. However, expression levels of other KLHL family proteins were comparable between the wild-type and mutant mice. These findings indicate that the decreased abundance of KLHL3 is a specific phenomenon caused by mutant CUL3 ( Δexon9). Our findings would improve our understanding of the pathogenesis of PHAII caused byCUL3 mutation in vivo. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - June 5, 2018 Category: Urology & Nephrology Source Type: research

Molecular mechanisms underlying uremic toxin-related systemic disorders in chronic kidney disease: focused on β 2 -microglobulin-related amyloidosis and indoxyl sulfate-induced atherosclerosis—Oshima Award Address 2016
AbstractUremic toxins are linked to chronic kidney disease (CKD)-related systemic diseases. β2-Microglobulin ( β2-m), a water-soluble, middle-sized molecule, is associated with mortality and dialysis-related amyloidosis (DRA). DRA occurs in long-term dialysis patients, with β2-m amyloid deposited mainly in osteoarticular tissues. We investigated a model of β2-m amyloid fibril extension at neutral pH in the presence of trifluoroethanol or sodium dodecyl sulfate. Using this model, some biological molecules, including glycosaminoglycans and lysophospholipids, were found to be chaperones for β2-m amylo...
Source: Clinical and Experimental Nephrology - June 5, 2018 Category: Urology & Nephrology Source Type: research

A consensus statement on health-care transition of patients with childhood-onset chronic kidney diseases: providing adequate medical care in adolescence and young adulthood
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - June 4, 2018 Category: Urology & Nephrology Source Type: research

Decrease in toe pinch force in male type 2 diabetic patients with diabetic nephropathy
AbstractBackgroundThe purpose of this cross-sectional study was to investigate the toe pinch force (TPF) of type 2 diabetic patients with diabetic nephropathy by disease stage, and to clarify the factors affecting the TPF.MethodsSeventy-four men with diabetic nephropathy (age: 62.7  ± 8.9 years, duration of diabetes: 14.2 ± 8.6 years) were enrolled. According to the staging of diabetic nephropathy, TPF and knee extension force (KEF) were compared among three groups: normoalbuminuria, microalbuminuria, and overt nephropathy. In addition, we investigated factors influ encing TPF...
Source: Clinical and Experimental Nephrology - May 17, 2018 Category: Urology & Nephrology Source Type: research

Long-term outcome of congenital nephrotic syndrome after kidney transplantation in Japan
ConclusionsLong-term outcome in these 14 CNF patients showed satisfactory graft survival, improved height SD score, and favorable development. Although recurrent proteinuria after transplant was not predictive, it was associated with graft survival rate. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - May 17, 2018 Category: Urology & Nephrology Source Type: research

Safety and Efficacy of Benzbromarone and Febuxostat in Hyperuricemia Patients with Chronic Kidney Disease: A Prospective Pilot Study
This study was a single-centered, parallel-grouped, randomized clinical trial (RCT). We randomly assigned hyperuricemia participants with eGFR 20 –60 mL/min/1.73 m2 into benzbromarone and febuxostat treatment group. Drugs were adjusted by titration from small doses.ResultsSeventy-three eligible participants enrolled, 66 subjects (33 in each group) were included finally for analysis. When compared to baseline, serum uric acid (SUA) decreased significantly after treatment in both groups, but no differences were detected among all the follow-up points. After 12-month treatment, eGFR did not have significant ch...
Source: Clinical and Experimental Nephrology - May 14, 2018 Category: Urology & Nephrology Source Type: research

Glucocorticoids in the treatment of patients with primary focal segmental glomerulosclerosis and moderate proteinuria
AbstractBackgroundTo compare the efficacy of glucocorticoids in primary focal segmental glomerulosclerosis (pFSGS) patients with moderate proteinuria. Registered athttp://www.chictr.org.cn/, study No. ChiCTR-OPN-17012789.MethodspFSGS patients with urine protein between 1.0 and 3.5  g/24 h were recruited from 2006 to 2016. No decline in urine protein >  50% was observed after 2 months of run-in angiotensin-converting enzyme inhibitors/angiotensin-receptor blockers (ACEI/ARB) treatment. Patients were assigned to study group (glucocorticoids with ACEI/ARB) or control group (ACEI/ARB without glucocor...
Source: Clinical and Experimental Nephrology - May 14, 2018 Category: Urology & Nephrology Source Type: research

Effect of combined vitamin D receptor activator and lanthanum carbonate on serum fibroblast growth factor 23 level in predialysis patients (CVD-LAF study): design and method
AbstractBackgroundWhether vitamin D receptor activator (VDRA) use is beneficial in chronic kidney disease (CKD) is unclear, because it is possible that VDRA increases serum fibroblast growth factor 23 (FGF23) levels. We will conduct a randomized controlled trial in predialysis patients to determine the effect of VDRA alone or in combination with lanthanum carbonate (LC) on serum FGF23 levels.MethodsThis is a single-center, open-label, randomized controlled trial. Enrollment will commence February 1, 2018, using the following inclusion criteria: (1) age  ≥ 20 years, (2) CKD with an estimated glomerular filt...
Source: Clinical and Experimental Nephrology - May 10, 2018 Category: Urology & Nephrology Source Type: research

Biomarkers for IgA nephropathy on the basis of multi-hit pathogenesis
AbstractIgA nephropathy (IgAN) is the most prevalent glomerular disease worldwide and is associated with a poor prognosis. Development of curative treatment strategies and approaches for early diagnosis is necessary. Renal biopsy is the gold standard for the diagnosis and assessment of disease activity. However, reliable biomarkers are needed for the noninvasive diagnosis of this disease and to more fully delineate the risk of progression. With regard to the pathogenesis of IgAN, the multi-hit hypothesis, including production of galactose-deficient IgA1 (Gd-IgA1; Hit 1), IgG or IgA autoantibodies that recognize Gd-IgA1 (Hi...
Source: Clinical and Experimental Nephrology - May 8, 2018 Category: Urology & Nephrology Source Type: research

On the nature of toenail opacities in renal insufficiency
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - May 5, 2018 Category: Urology & Nephrology Source Type: research

The impact of serum uric acid reduction on renal function and blood pressure in chronic kidney disease patients with hyperuricemia
AbstractBackgroundFebuxostat is tolerable in chronic kidney disease (CKD) patients with hyperuricemia. However, the long-term effect of lowering uric acid with febuxostat on renal function and blood pressure has not been elucidated.MethodsThis was a 2  years retrospective observational study. 86 CKD patients with hyperuricemia who continued with allopurinol (allopurinol group,n = 30), switched from allopurinol to febuxostat (switched group,n = 25), or were newly prescribed febuxostat (febuxostat group,n = 31) were included in this study. Serum uric acid, estimated glomerular f...
Source: Clinical and Experimental Nephrology - April 26, 2018 Category: Urology & Nephrology Source Type: research

Regional variations in immunosuppressive therapy in patients with primary nephrotic syndrome: the Japan nephrotic syndrome cohort study
ConclusionUse of intravenous methylprednisolone for MCD and MN differed geographically in Japan. Its efficacy should be further evaluated in a well-designed trial. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - April 20, 2018 Category: Urology & Nephrology Source Type: research

Low frequency of cervicocranial artery involvement in Japanese with renal artery fibromuscular dysplasia compared with that of Caucasians
ConclusionThese findings suggest that cervical artery involvement and intracranial artery involvement are not common in renal FMD patients in Japan, which is in contrast to the data reported for Caucasian patients in Western countries. Ethnic differences could influence the occurrence of cervicocranial lesions. A study with a larger sample size should be performed to validate these findings. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - April 20, 2018 Category: Urology & Nephrology Source Type: research

Sodium valproate-induced Fanconi syndrome in two severely disabled patients receiving carnitine supplementation
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - April 20, 2018 Category: Urology & Nephrology Source Type: research

Low serum phosphate is associated with ischemic stroke in hemodialysis patients
AbstractBackgroundHemodialysis patients have a high incidence of ischemic stroke. However, the association between serum phosphate levels and ischemic stroke is controversial among hemodialysis patients. The present study is used to evaluate whether serum phosphate levels are associated with ischemic stroke among patients undergoing hemodialysis.MethodsA total of 84 hemodialysis patients were followed up for 8  years. Data collection included chart reviews and assessments of laboratory records. The ischemic stroke diagnosis was made on the basis of history, physical examination and neuroimaging (computed tomography an...
Source: Clinical and Experimental Nephrology - April 20, 2018 Category: Urology & Nephrology Source Type: research

Oral adsorbent AST-120 ameliorates gut environment and protects against the progression of renal impairment in CKD rats
ConclusionAST ameliorated renal function with the restoration ofLact and tight junction through TLR pathway, which would mitigate systemic inflammation and contributed to their renoprotective effects. Our study provides a novel mechanism of the renoprotective effects by AST. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - April 19, 2018 Category: Urology & Nephrology Source Type: research

Transition from acute kidney injury to chronic kidney disease: a single-centre cohort study
ConclusionsOur study revealed that AKI events can cause a decline in kidney function and, as more AKI events occur, acceleration of this decline. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - April 9, 2018 Category: Urology & Nephrology Source Type: research

Association between renal function and cardiovascular and all-cause mortality in the community-based elderly population: results from the Specific Health Check and Guidance Program in Japan
AbstractBackgroundChronic kidney disease is a significant risk factor for end-stage kidney disease, cardiovascular events, and premature death. However, the prognostic value of low estimated glomerular filtration rate (eGFR) in the elderly is debatable.MethodsWe determined eGFR using the Japanese equation in 132,160 elderly subjects (65 –75 years) who attended the special health checkup (Tokutei-Kenshin) in 2008 and investigated the association between baseline eGFR and 5-year all-cause and cardiovascular mortality.ResultsThe median (SD) eGFR was 70.5  ± 15.3 mL/min/1.73 m2. During fol...
Source: Clinical and Experimental Nephrology - March 5, 2018 Category: Urology & Nephrology Source Type: research

Effects of topiroxostat in hyperuricemic patients with chronic kidney disease
ConclusionsTopiroxostat reduced SUA levels effectively and may exhibit renoprotective effect in hyperuricemic patients with CKD. Further studies are required to clarify whether topiroxostat prevents the progression of renal disease and improves the prognosis of CKD patients. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - March 5, 2018 Category: Urology & Nephrology Source Type: research

The assessment of renal cortex and parenchymal volume using automated CT volumetry for predicting renal function after donor nephrectomy
We examined whether CT volumetry of the kidney can be a new tool for evaluating SRF.MethodsSixty-three patients underwent live donor nephrectomy. Patients without a 1.0  mm slice CT or follow-up for
Source: Clinical and Experimental Nephrology - March 5, 2018 Category: Urology & Nephrology Source Type: research

Risk factors for progression of chronic kidney disease in the EPPIC trials and the effect of AST-120
ConclusionsCKD progression may have an association with baseline UP/UCr and hematuria. Treatment with AST-120 may delay the time to the primary endpoint in patients with progressive CKD receiving standard therapy, thus warranting further investigation. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - March 5, 2018 Category: Urology & Nephrology Source Type: research

Diabetes mellitus as a cause or comorbidity of chronic kidney disease and its outcomes: the Gonryo study
ConclusionsWe found that DN patients have a higher risk for ESKD than DM and NDRD or non-DM patients. In particular, GFR rapidly declined in DN at stage G3b. DM and NDRD patients can accomplish equally beneficial renal outcomes as non-DM CKD, regardless of their similar metabolic profiles as DN. In conclusion, we should prudentially consider the risk stratification of DM whether cause or comorbidity of CKD. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - March 5, 2018 Category: Urology & Nephrology Source Type: research

Abdominal involvement in minimal change nephrotic syndrome
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - March 5, 2018 Category: Urology & Nephrology Source Type: research

Elevation of the serum liver enzyme levels during tolvaptan treatment in patients with autosomal dominant polycystic kidney disease (ADPKD)
ConclusionIn patients with mild elevation of the serum liver enzyme, as is less than three times the upper limit of normal (ULN), resumption of tolvaptan may be considered after the serum liver enzyme levels return to normal range. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - March 5, 2018 Category: Urology & Nephrology Source Type: research

Is low pre-transplant parathyroid hormone a risk marker for cardiovascular disease in long-term follow-up of renal transplant recipients?
ConclusionLow levels of parathyroid hormone before transplantation were associated with increased risk of post-transplant vascular events both in patients with and without pre-transplant parathyroidectomy. Any conclusions on causal or direct effect of PTH on outcome cannot be drawn from this observational study. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - February 24, 2018 Category: Urology & Nephrology Source Type: research

Activation of AQP2 water channels without vasopressin: therapeutic strategies for congenital nephrogenic diabetes insipidus
AbstractCongenital nephrogenic diabetes insipidus (NDI) is characterized by defective urine concentrating ability. Symptomatic polyuria is present from birth, even with normal release of the antidiuretic hormone vasopressin by the pituitary. Over the last two decades, theaquaporin-2 (AQP2) gene has been cloned and the molecular mechanisms of urine concentration have been gradually elucidated. Vasopressin binds to the vasopressin type II receptor (V2R) in the renal collecting ducts and then activates AQP2 phosphorylation and trafficking to increase water reabsorption from urine. Most cases of congenital NDI are caused by lo...
Source: Clinical and Experimental Nephrology - February 24, 2018 Category: Urology & Nephrology Source Type: research

pH after the first session of direct hemoperfusion with polymyxin B-immobilized fibers predicts mortality in patients with sepsis and septic shock
AbstractBackgroundThe definition of sepsis was updated to sepsis-3 in February 2016. Currently, direct hemoperfusion therapy using the polymyxin B-immobilized fiber cartridge (PMX-DHP) is widely performed to treat sepsis and septic shock. However, the prognostic factors of PMX-DHPs in patients with sepsis using the new definition are unclear. We retrospectively assessed prognostic factors in patients who had received PMX-DHP therapy for sepsis and septic shock.MethodsWe included 71 patients with severe infection who underwent PMX-DHP treatment from January 2006 to August 2015 in this study. Participants were re-evaluated a...
Source: Clinical and Experimental Nephrology - February 24, 2018 Category: Urology & Nephrology Source Type: research

Renal hemosiderosis with uncontrolled hypertension
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - February 22, 2018 Category: Urology & Nephrology Source Type: research

Semaphorin 7A in circulating regulatory T cells is increased in autosomal-dominant polycystic kidney disease and decreases with tolvaptan treatment
ConclusionsSEMA7A shows potential as both a therapeutic target in mammalian kidney fibrosis and as a marker of inflammation in ADPKD patients. SEMA7A expression was lower after tolvaptan treatment, which may reflect drug efficacy. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - February 16, 2018 Category: Urology & Nephrology Source Type: research

Effect of topiroxostat in patients with diabetic nephropathy and gout or hyperuricemia: fact or fallacy
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - February 16, 2018 Category: Urology & Nephrology Source Type: research

Significance of early detection of acute kidney function worsening among outpatients having CKD using automatic calculation system for the rate of eGFR decline
AbstractBackgroundTo retard progression of chronic kidney disease (CKD) and reduce end-stage kidney disease, it is important to detect acute kidney function worsening on CKD (AW-CKD) immediately and bring back their kidney functions to baselines by appropriate treatment. However, in general outpatient practice, it is difficult to detect the change in the slope of estimated glomerular filtration rate (eGFR).MethodsWe made automatic calculation system for the rate of eGFR decline ( ΔeGFR), and retrospectively observed the situation of AW-CKD among outpatients, who had visited all clinical departments of Steel Memorial ...
Source: Clinical and Experimental Nephrology - February 14, 2018 Category: Urology & Nephrology Source Type: research

Ensuring safe drug administration to pediatric patients with renal dysfunction: a multicenter study
ConclusionsFor the majority of the investigated drugs, the awareness that we need to reduce dosages for patients with renal dysfunction was insufficient. To ensure safe drug administration, communication between physicians and pharmacists is paramount. There is an urgent need for the creation of a safe drug administration protocol for pediatric patients with renal dysfunction. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - February 6, 2018 Category: Urology & Nephrology Source Type: research

Cinacalcet HCl therapy in East Asian patients and rs1042636 carriers
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - February 6, 2018 Category: Urology & Nephrology Source Type: research

Correction to: Association of adiposity with hemoglobin levels in patients with chronic kidney disease not on dialysis
AbstractThe article Association of adiposity with hemoglobin levels in patients with chronic kidney disease not on dialysis, written by Hirokazu Honda, Kota Ono, Tadao Akizawa, Kosaku Nitta and Akira Hishida, was originally published electronically on the publisher ’s internet portal (currently springerlink) on November 4, 2017 without open access. With the author(s)’ decision to opt for Open Choice, the copyright of the article changed on February 6, 2018 to © The Author(s) [2017] and the article is forthwith distributed under the terms of the Creative C ommons Attribution 4.0 International License (http:...
Source: Clinical and Experimental Nephrology - February 6, 2018 Category: Urology & Nephrology Source Type: research

Progressive kidney disease may not alter the association of hyponatremia with mortality
ConclusionsThe association between community acquired hyponatremia and mortality showed consistent HRs across progressive stages of CKD and AKI suggesting that the contribution of tubular dysfunction to hyponatremia in advanced kidney disease does not alter this association. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - February 2, 2018 Category: Urology & Nephrology Source Type: research

AQP2 in human urine is predominantly localized to exosomes with preserved water channel activities
ConclusionTaken together, AQP2 is localized predominantly to urinary exosomes with preserved water channel activities. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - February 2, 2018 Category: Urology & Nephrology Source Type: research

Essentials from clinical practice guidelines for CKD stage G3b-5 2017
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - February 1, 2018 Category: Urology & Nephrology Source Type: research

Optimal conditions and the advantages of using laser microdissection and liquid chromatography tandem mass spectrometry for diagnosing renal amyloidosis
ConclusionThe use of 10 laser microdissected glomeruli (170,000 –220,000 µm2) with amyloid deposition from FFPE sections digested with trypsin 3  µL (0.1 mg/mL) allowed the accurate detection of amyloid protein in AA and AL amyloidosis. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - January 25, 2018 Category: Urology & Nephrology Source Type: research

Uric acid-lowering and renoprotective effects of topiroxostat, a selective xanthine oxidoreductase inhibitor, in patients with diabetic nephropathy and hyperuricemia: a randomized, double-blind, placebo-controlled, parallel-group study (UPWARD study)
AbstractBackgroundHyperuricemia is supposed to be an independent risk factor for kidney dysfunction in diabetic patients. We attempted to examine the uric acid-lowering effect and the renoprotective effect of topiroxostat, a selective xanthine oxidoreductase inhibitor, in patients with diabetic nephropathy and hyperuricemia in this pilot study.MethodsThe study design was randomized, double-blind, placebo-controlled, parallel-group study. A total of 65 patients with hyperuricemia and diabetic nephropathy with microalbuminuria were enrolled and assigned to either the topiroxostat group or the placebo group. Topiroxostat (ste...
Source: Clinical and Experimental Nephrology - January 25, 2018 Category: Urology & Nephrology Source Type: research

Validation of estimated glomerular filtration rate equations for Japanese children
ConclusionThe bias of each eGFR equation was not large. Therefore, each eGFR equation could be used. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - January 25, 2018 Category: Urology & Nephrology Source Type: research