New insight into the management of IgA nephropathy
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - November 12, 2018 Category: Urology & Nephrology Source Type: research

Investigation on the benefits of mycophenolate mofetil and therapeutic drug monitoring in the treatment of Japanese patients with lupus nephritis
AbstractBackgroundMycophenolate mofetil (MMF) is recommended as a first-line immunosuppressant to treat lupus nephritis (LN). Prognosis and therapeutic response in LN are known to vary depending on race. We investigated the benefits of MMF and therapeutic drug monitoring (TDM) in the treatment of Japanese LN patients.MethodsIn this retrospective cohort study, a total of 20 patients with LN who started MMF treatment were included. Clinical data were collected regularly after MMF administration. We evaluated complete remission (CR) rate as the primary outcome. Predictors of CR were identified using univariate and multivariat...
Source: Clinical and Experimental Nephrology - November 12, 2018 Category: Urology & Nephrology Source Type: research

Reduced renal functional reserve as the mechanism linking acute kidney injury to proteinuria
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - November 12, 2018 Category: Urology & Nephrology Source Type: research

Giant cell arteritis presenting with ANCA-associated glomerulonephritis
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - November 12, 2018 Category: Urology & Nephrology Source Type: research

Peritoneal dialysis patient having fish bone-induced colon perforation
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - November 12, 2018 Category: Urology & Nephrology Source Type: research

T cells in IgA nephropathy: role in pathogenesis, clinical significance and potential therapeutic target
ConclusionsT cells play an important role in IgAN pathogenesis and are correlated with its clinical severity. Clinical trials with the drugs targeting the reported alterations of the T-cell compartment are highly desirable. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - November 7, 2018 Category: Urology & Nephrology Source Type: research

JAK2/STAT3/BMP-2 axis and NF- κB pathway are involved in erythropoietin-induced calcification in rat vascular smooth muscle cells
ConclusionEPO could promote VSMCs calcificationin vitro andin vivo and this effect may be achieved through the JAK2/STAT3/BMP-2 axis and NF- κB pathway. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - November 7, 2018 Category: Urology & Nephrology Source Type: research

Foreign-body reaction to lanthanum on gastric mucosa
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - November 7, 2018 Category: Urology & Nephrology Source Type: research

Temporal change in life and renal prognosis of rapidly progressive glomerulonephritis in Japan via nationwide questionnaire survey
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - October 31, 2018 Category: Urology & Nephrology Source Type: research

A grading system that predicts the risk of dialysis induction in IgA nephropathy patients based on the combination of the clinical and histological severity
AbstractHistological classification is essential in the clinical management of immunoglobulin A nephropathy (IgAN). However, there are limitations in predicting the prognosis of IgAN based on histological information alone, which suggests the need for better prognostic models. Therefore, we defined a prognostic model by combining the grade of clinical severity with the histological grading system by the following processes. We included 270 patients and explored the clinical variables associated with progression to end-stage renal disease (ESRD). Then, we created a predictive clinical grading system and defined the risk gra...
Source: Clinical and Experimental Nephrology - October 26, 2018 Category: Urology & Nephrology Source Type: research

Enhanced angiotensinogen expression in neonates during kidney development
ConclusionsEnhanced AGT expression and urinary AGT excretion may reflect intrarenal RAS activation associated with kidney development in utero. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - October 23, 2018 Category: Urology & Nephrology Source Type: research

List of referees
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - October 22, 2018 Category: Urology & Nephrology Source Type: research

Chloroquine attenuates TLR3-mediated plasminogen activator inhibitor-1 expression in cultured human glomerular endothelial cells
ConclusionConsidering that TLR3 signaling is implicated in LN pathogenesis, our results suggest that chloroquine exert postulated renoprotective effects by inhibiting PAI-1 expression. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - October 20, 2018 Category: Urology & Nephrology Source Type: research

An inpatient educational program for chronic kidney disease
In this study, we evaluated the effectiveness of a 1-week inpatient education program, delivered during the predialysis stage of CKD, in slowing the deterioration in renal function over the subsequent 2 years, and identified factors influencing the program ’s effectiveness.MethodsWe retrospectively evaluated the estimated glomerular filtration rate (eGFR) of 105 consecutive patients who completed the program, at the following time points: 6 months prior to program initiation, at program initiation and, at 6, 12, 18, and 24 months after the program. To identify factors predictive of program effectiveness, we classifie...
Source: Clinical and Experimental Nephrology - October 19, 2018 Category: Urology & Nephrology Source Type: research

Usefulness of multidisciplinary care to prevent worsening renal function in chronic kidney disease
ConclusionComprehensive multidisciplinary care of outpatients might help prevent worsening renal function among patients with CKD. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - October 19, 2018 Category: Urology & Nephrology Source Type: research

Analysis of opossum kidney NaPi-IIc sodium-dependent phosphate transporter to understand Pi handling in human kidney
ConclusionThese findings suggest that NaPi-IIc is important for the expression of NaPi-IIa (NaPi-4) protein in OK cells. Suppression of Npt2c may downregulate Npt2a function in HHRH patients. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - October 13, 2018 Category: Urology & Nephrology Source Type: research

Histopathological classification of anti-neutrophil cytoplasmic antibody-associated glomerulonephritis in a nationwide Japanese prospective 2-year follow-up cohort study
ConclusionThis histopathological classification was valuable for both the stratification of renal function and the estimation of partial renal survival during 2-year follow-up in ANCA-associated glomerulonephritis. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - October 10, 2018 Category: Urology & Nephrology Source Type: research

Clinical significance of mesangial IgM deposition in patients with IgA nephropathy
AbstractBackgroundGlomerular immunoglobulin G deposition in patients with immunoglobulin A nephropathy (IgAN) has been shown to be associated with adverse renal outcomes. Clinical significance of mesangial immunoglobulin M (IgM) deposition in these patients remains to be proven.MethodsOne hundred patients who had a diagnosis of IgAN between 2001 and 2017 were enrolled. Patients were divided into two groups based on mesangial IgM deposition status. Groups were compared for demographic, clinical, and pathologic variables at baseline and in follow-up. Cox regression analysis was performed to evaluate the effect of mesangial I...
Source: Clinical and Experimental Nephrology - October 6, 2018 Category: Urology & Nephrology Source Type: research

The association between urinary sodium excretion and blood pressure in a community-based population: the Yamagata (Takahata) study
ConclusionsThese results demonstrated that the association between blood pressure and urinary sodium excretion was strengthened by characteristics of subjects such as aging, presence of diabetes, and renal impairment in the community-based population. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - October 6, 2018 Category: Urology & Nephrology Source Type: research

Effect of achieved hemoglobin level on renal outcome in non-dialysis chronic kidney disease (CKD) patients receiving epoetin beta pegol: MIRcerA CLinical Evidence on Renal Survival in CKD patients with renal anemia (MIRACLE-CKD Study)
AbstractBackgroundPrevious randomized-controlled trials have shown that targeting higher hemoglobin (Hb) levels using high dose of ESA in non-dialysis chronic kidney disease (NDCKD) patients resulted in poorer cardiovascular outcome; however, it remains unknown how high Hb levels achieved by ESA in clinical practice dose could affect renal outcome.MethodsIn a multicenter prospective observational study, Japanese NDCKD patients with an estimated glomerular filtration rate (eGFR) of ≥ 6 mL/min/1.73 m2 and renal anemia (Hb  
Source: Clinical and Experimental Nephrology - October 5, 2018 Category: Urology & Nephrology Source Type: research

The urate-lowering efficacy and safety of febuxostat versus allopurinol in Chinese patients with asymptomatic hyperuricemia and with chronic kidney disease stages 3 –5
AbstractBackgroundWhile the dose of allopurinol is limited in patients with chronic kidney disease (CKD), information is lacking concerning the efficacy, safety, and maintenance dose of febuxostat in Chinese patients with hyperuricemia and with CKD stages 3 –5.MethodsA single center, prospective cohort study was conducted in patients with CKD stages 3 –5 and with hyperuricemia who had not yet begun to undergo renal replacement therapy. We enrolled 208 patients who were newly treated with febuxostat (n = 112) or allopurinol (n = 96) in this study. The efficacy of febuxostat was determ...
Source: Clinical and Experimental Nephrology - October 5, 2018 Category: Urology & Nephrology Source Type: research

Manual compression and reflex syncope in native renal biopsy
ConclusionManual compression and abdominal bandage significantly increased the frequency of reflex syncope during native PRB. It is necessary to consider the potential benefit and risk of compression maneuvers for each patient undergoing this procedure. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - October 1, 2018 Category: Urology & Nephrology Source Type: research

Oral adsorbent AST-120 ameliorates gut environment and protects against the progression of renal impairment in CKD rats
ConclusionAST ameliorated renal function with the restoration ofLact and tight junction through TLR pathway, which would mitigate systemic inflammation and contributed to their renoprotective effects. Our study provides a novel mechanism of the renoprotective effects by AST. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - October 1, 2018 Category: Urology & Nephrology Source Type: research

Initial treatment with pulse methylprednisolone followed by short-term prednisolone and tonsillectomy for childhood IgA nephropathy
ConclusionsAs an initial treatment, IVMP followed by short-term PSL and tonsillectomy appears to be effective for treating childhood IgAN. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - October 1, 2018 Category: Urology & Nephrology Source Type: research

Change in the quality of life of caregivers of pediatric department patients undergoing kidney transplantation: a single-center prospective study
ConclusionDialysis of children before KTx was a particularly larger burden for caregivers. The child ’s comorbidities and social adaptation problems might be focused after KTx, we need to evaluate for more long-term QOL of caregivers. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - October 1, 2018 Category: Urology & Nephrology Source Type: research

Hypertension and its severity in children with steroid sensitive nephrotic syndrome during remission
ConclusionThere is high incidence of hypertension in NS children during remission. Though significant positive correlation was found with positive family history of hypertension and deranged lipid profile highlighting possibility of essential hypertension in them, there is need for close active monitoring and management of hypertension in them as untreated cases may have significant target organ damage. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - October 1, 2018 Category: Urology & Nephrology Source Type: research

Practice pattern of physician ’s directions of exercise restriction in patients with chronic kidney disease: results from the Chronic Kidney Disease Japan Cohort study
ConclusionsThe findings from this study suggested the factors related with prescribing exercise restrictions. Further studies examining which patients with CKD need direction of exercise restrictions are needed. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - October 1, 2018 Category: Urology & Nephrology Source Type: research

Pre-operative and post-operative estimated glomerular filtration rate in Japanese patients with urological malignancies
We examined the relationship between creatinine clearance-based measured GFR (mGFR) versus estimated GFR (eGFR) calculated by 3 popular equations, 4-variable Modification of Diet in Renal Disease equation adjusted by Japanese correction coefficient (cmMDRD), 3-variable MDRD equation for Japanese population (eGFRcreat), and Chronic Kidney Disease-Epidemiology Collaboration equation adjusted by Japanese correction coefficient (cmCKD-EPI) in Japanese patients who had undergone RN or RNU due to renal cell carcinoma or upper tract urothelial carcinoma before and after surgery.ResultsAmong the 3 equations examined, eGFRcreat was...
Source: Clinical and Experimental Nephrology - October 1, 2018 Category: Urology & Nephrology Source Type: research

pH after the first session of direct hemoperfusion with polymyxin B-immobilized fibers predicts mortality in patients with sepsis and septic shock
AbstractBackgroundThe definition of sepsis was updated to sepsis-3 in February 2016. Currently, direct hemoperfusion therapy using the polymyxin B-immobilized fiber cartridge (PMX-DHP) is widely performed to treat sepsis and septic shock. However, the prognostic factors of PMX-DHPs in patients with sepsis using the new definition are unclear. We retrospectively assessed prognostic factors in patients who had received PMX-DHP therapy for sepsis and septic shock.MethodsWe included 71 patients with severe infection who underwent PMX-DHP treatment from January 2006 to August 2015 in this study. Participants were re-evaluated a...
Source: Clinical and Experimental Nephrology - October 1, 2018 Category: Urology & Nephrology Source Type: research

Butyrylcholinesterase level as an independent factor of erythropoiesis-stimulating agent resistance in patients on maintenance hemodialysis: a single-center cross-sectional study
AbstractBackgroundErythropoiesis-stimulating agent (ESA) responsiveness is related to the nutritional status of patients on hemodialysis (HD). Serum butyrylcholinesterase (BChE), an alpha-glycoprotein, may decrease in case of malnutrition. We investigated whether BChE was independently related to ESA resistance in patients on HD.MethodsThe laboratory data and ESA resistance index (ERI), defined as ESA dosage per week divided by dry weight and hemoglobin, were investigated in 215 patients on HD between July and September 2017. Malnutrition was defined as Geriatric Nutritional Risk Index (GNRI) of
Source: Clinical and Experimental Nephrology - October 1, 2018 Category: Urology & Nephrology Source Type: research

Elevation of the serum liver enzyme levels during tolvaptan treatment in patients with autosomal dominant polycystic kidney disease (ADPKD)
ConclusionIn patients with mild elevation of the serum liver enzyme, as is less than three times the upper limit of normal (ULN), resumption of tolvaptan may be considered after the serum liver enzyme levels return to normal range. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - October 1, 2018 Category: Urology & Nephrology Source Type: research

Visit-to-visit blood pressure variability in children and adolescents with renal disease
In this study, we examined whether visit-to-visit variability (VVV) could predict WCH and whether VVV correlated with eGFR, eGFR slope, and albuminuria/proteinuria in children and adolescents with renal diseases.MethodsVVV was determined as average real variability of office BP measurements between visits, and 24-h BPV as the standard deviation of 24-h ambulatory BP. In 35 renal patients (25 boys and 10 girls, 7 –18 years of age), divided into normotension (NT), WCH, and hypertension (HTN), the relationships between VVV and 24-h BPV and VVV in each BP category were studied. In separate 48 renal patients (24 boys...
Source: Clinical and Experimental Nephrology - October 1, 2018 Category: Urology & Nephrology Source Type: research

Low serum phosphate is associated with ischemic stroke in hemodialysis patients
AbstractBackgroundHemodialysis patients have a high incidence of ischemic stroke. However, the association between serum phosphate levels and ischemic stroke is controversial among hemodialysis patients. The present study is used to evaluate whether serum phosphate levels are associated with ischemic stroke among patients undergoing hemodialysis.MethodsA total of 84 hemodialysis patients were followed up for 8  years. Data collection included chart reviews and assessments of laboratory records. The ischemic stroke diagnosis was made on the basis of history, physical examination and neuroimaging (computed tomography an...
Source: Clinical and Experimental Nephrology - October 1, 2018 Category: Urology & Nephrology Source Type: research

The size of the renal artery orifice contributes to laterality of acute renal infarction
ConclusionThe size of the renal artery orifice may be a factor that contributes to the laterality of ARI. Assessment of anatomical features is important when considering the laterality of the disease. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - October 1, 2018 Category: Urology & Nephrology Source Type: research

GFR-estimation by serum creatinine during glucocorticosteroid therapy
ConclusionGCS use had no significant effect on serum creatinine as a marker for kidney function in a mixed population of renal outpatient clinic children. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - October 1, 2018 Category: Urology & Nephrology Source Type: research

Association between exercise intensity and renal blood flow evaluated using ultrasound echo
This study examined variations in RBF at different exercise intensities using ultrasound echo.MethodsEight healthy men with normal renal function (eGFRcys 114  ± 19 mL/min/1.73 m2) participated in this study. Using a bicycle ergometer, participants underwent an incremental exercise test using a ramp protocol (20  W/min) until exhaustion in Study 1 and the lactate acid breaking point (LaBP) was calculated. Participants underwent a multi-stage test at exercise intensities of 60, 80, 100, 120, and 140% LaBP in Study 2. RBF was measured by ultrasound echo at rest and 5 min after exercis...
Source: Clinical and Experimental Nephrology - October 1, 2018 Category: Urology & Nephrology Source Type: research

Defective renal autoregulation in the chronic bile duct ligation model of liver failure
ConclusionTubuloglomerular feedback (TGF) responses were significantly attenuated in BDL rats, especially in the subnormal flow range. Impairment of renal blood flow autoregulation, to some extent mediated by reduced TGF-mediated vasodilatation, may contribute to the renal vascular constrictor state in liver cirrhosis by preventing the full dilatory response to the blood pressure reduction. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - October 1, 2018 Category: Urology & Nephrology Source Type: research

Effect of topiroxostat in patients with diabetic nephropathy and gout or hyperuricemia: fact or fallacy
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - October 1, 2018 Category: Urology & Nephrology Source Type: research

Renal hemosiderosis with uncontrolled hypertension
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - October 1, 2018 Category: Urology & Nephrology Source Type: research

Early renoprotection by anemia correction
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - October 1, 2018 Category: Urology & Nephrology Source Type: research

Scanning electron microscopy of polycystic liver disease
AbstractResected specimens of PCLD by laparoscopic fenestration surgery were evaluated by scanning electron microscopy. Epithelium lining the largest cyst (26 cm in size) showed prominent villous proliferation with positivity of Ki-67, while the epithelium of the small cyst (3 cm in size) showed slight proliferation (smooth) with small positivity of Ki-67. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - October 1, 2018 Category: Urology & Nephrology Source Type: research

Manual compression and reflex syncope in native renal biopsy
ConclusionManual compression and abdominal bandage significantly increased the frequency of reflex syncope during native PRB. It is necessary to consider the potential benefit and risk of compression maneuvers for each patient undergoing this procedure. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - September 17, 2018 Category: Urology & Nephrology Source Type: research

Initial treatment with pulse methylprednisolone followed by short-term prednisolone and tonsillectomy for childhood IgA nephropathy
ConclusionsAs an initial treatment, IVMP followed by short-term PSL and tonsillectomy appears to be effective for treating childhood IgAN. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - September 17, 2018 Category: Urology & Nephrology Source Type: research

Hypertension and its severity in children with steroid sensitive nephrotic syndrome during remission
ConclusionThere is high incidence of hypertension in NS children during remission. Though significant positive correlation was found with positive family history of hypertension and deranged lipid profile highlighting possibility of essential hypertension in them, there is need for close active monitoring and management of hypertension in them as untreated cases may have significant target organ damage. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - September 17, 2018 Category: Urology & Nephrology Source Type: research

Practice pattern of physician ’s directions of exercise restriction in patients with chronic kidney disease: results from the Chronic Kidney Disease Japan Cohort study
ConclusionsThe findings from this study suggested the factors related with prescribing exercise restrictions. Further studies examining which patients with CKD need direction of exercise restrictions are needed. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - September 17, 2018 Category: Urology & Nephrology Source Type: research

Pre-operative and post-operative estimated glomerular filtration rate in Japanese patients with urological malignancies
We examined the relationship between creatinine clearance-based measured GFR (mGFR) versus estimated GFR (eGFR) calculated by 3 popular equations, 4-variable Modification of Diet in Renal Disease equation adjusted by Japanese correction coefficient (cmMDRD), 3-variable MDRD equation for Japanese population (eGFRcreat), and Chronic Kidney Disease-Epidemiology Collaboration equation adjusted by Japanese correction coefficient (cmCKD-EPI) in Japanese patients who had undergone RN or RNU due to renal cell carcinoma or upper tract urothelial carcinoma before and after surgery.ResultsAmong the 3 equations examined, eGFRcreat was...
Source: Clinical and Experimental Nephrology - September 17, 2018 Category: Urology & Nephrology Source Type: research

Butyrylcholinesterase level as an independent factor of erythropoiesis-stimulating agent resistance in patients on maintenance hemodialysis: a single-center cross-sectional study
AbstractBackgroundErythropoiesis-stimulating agent (ESA) responsiveness is related to the nutritional status of patients on hemodialysis (HD). Serum butyrylcholinesterase (BChE), an alpha-glycoprotein, may decrease in case of malnutrition. We investigated whether BChE was independently related to ESA resistance in patients on HD.MethodsThe laboratory data and ESA resistance index (ERI), defined as ESA dosage per week divided by dry weight and hemoglobin, were investigated in 215 patients on HD between July and September 2017. Malnutrition was defined as Geriatric Nutritional Risk Index (GNRI) of
Source: Clinical and Experimental Nephrology - September 17, 2018 Category: Urology & Nephrology Source Type: research

Visit-to-visit blood pressure variability in children and adolescents with renal disease
In this study, we examined whether visit-to-visit variability (VVV) could predict WCH and whether VVV correlated with eGFR, eGFR slope, and albuminuria/proteinuria in children and adolescents with renal diseases.MethodsVVV was determined as average real variability of office BP measurements between visits, and 24-h BPV as the standard deviation of 24-h ambulatory BP. In 35 renal patients (25 boys and 10 girls, 7 –18 years of age), divided into normotension (NT), WCH, and hypertension (HTN), the relationships between VVV and 24-h BPV and VVV in each BP category were studied. In separate 48 renal patients (24 boys...
Source: Clinical and Experimental Nephrology - September 17, 2018 Category: Urology & Nephrology Source Type: research

The size of the renal artery orifice contributes to laterality of acute renal infarction
ConclusionThe size of the renal artery orifice may be a factor that contributes to the laterality of ARI. Assessment of anatomical features is important when considering the laterality of the disease. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - September 17, 2018 Category: Urology & Nephrology Source Type: research

Association between exercise intensity and renal blood flow evaluated using ultrasound echo
This study examined variations in RBF at different exercise intensities using ultrasound echo.MethodsEight healthy men with normal renal function (eGFRcys 114  ± 19 mL/min/1.73 m2) participated in this study. Using a bicycle ergometer, participants underwent an incremental exercise test using a ramp protocol (20  W/min) until exhaustion in Study 1 and the lactate acid breaking point (LaBP) was calculated. Participants underwent a multi-stage test at exercise intensities of 60, 80, 100, 120, and 140% LaBP in Study 2. RBF was measured by ultrasound echo at rest and 5 min after exercis...
Source: Clinical and Experimental Nephrology - September 17, 2018 Category: Urology & Nephrology Source Type: research