Non-invasive fibrosis assessments of non-alcoholic fatty liver disease associated with low estimated glomerular filtration rate among CKD patients: the Fukuoka Kidney disease Registry Study
We examined the association between FIB-4index or NFS and the odds of having low estimated glomerular filtration rate (eGFR) defined as eGFR  
Source: Clinical and Experimental Nephrology - April 15, 2021 Category: Urology & Nephrology Source Type: research

Nutritional status and risk of contrast-associated acute kidney injury in elderly patients undergoing percutaneous coronary intervention
This study aimed to investigate the connection between malnutrition evaluated by the Controlling Nutritional Status (CONUT) score and the risk of contrast-associated acute kidney injury (CA-AKI) in elderly patients who underwent percutaneous coronary intervention (PCI).MethodsA total of 1308 patients aged over 75  years undergoing PCI was included. Based on the CONUT score, patients were assigned to normal (0–1), mild malnutrition (2–4), moderate-severe malnutrition group (≥ 5). The primary outcome was CA-AKI (an absolute increase in ≥ 0.3 mg/dL or ≥ 50% rel...
Source: Clinical and Experimental Nephrology - April 12, 2021 Category: Urology & Nephrology Source Type: research

Estimating the prevalence of definitive chronic kidney disease in the Japanese general population
AbstractBackgroundMost data on chronic kidney disease (CKD) prevalence has been based on single measurements of renal function and proteinuria. The aim was to determine the prevalence of CKD diagnosed by chronic proteinuria and/or reduced eGFR in a recent year in Japan.MethodsIn the main study, using a population-based cohort in Japan, the overall prevalence of CKD, defined as persistent positive proteinuria and/or eGFR  
Source: Clinical and Experimental Nephrology - April 10, 2021 Category: Urology & Nephrology Source Type: research

Clinical and experimental approaches for imaging of acute kidney injury
AbstractComplex molecular cell dynamics in acute kidney injury and its heterogeneous etiologies in patient populations in clinical settings have revealed the potential advantages and disadvantages of emerging novel damage biomarkers. Imaging techniques have been developed over the past decade to further our understanding about diseased organs, including the kidneys. Understanding the compositional, structural, and functional changes in damaged kidneys via several imaging modalities would enable a more comprehensive analysis of acute kidney injury, including its risks, diagnosis, and prognosis. This review summarizes recent...
Source: Clinical and Experimental Nephrology - April 9, 2021 Category: Urology & Nephrology Source Type: research

Overlapping obesity-related glomerulopathy and immunoglobulin A nephropathy: clinical and pathologic characteristics and prognosis
In this study, we investigated the clinical and pathologic characteristics and prognosis of overlapping obesity-related glomerulopathy (ORG) and immunoglobulin A nephropathy (IgAN) (ORG  + IgAN), which is rare in the clinic.MethodsWe included 62 cases of ORG  + IgAN, 110 cases of ORG without other glomerulopathy (ORG alone) and 124 cases of IgAN without other glomerulopathy (IgAN alone). The clinical, pathologic and prognostic data were collected and compared.ResultsORG  + IgAN patients showed a higher incidence of body mass index (BMI), higher incidence of hyperuricemia, higher in...
Source: Clinical and Experimental Nephrology - April 2, 2021 Category: Urology & Nephrology Source Type: research

Relationship between compensatory hypertrophy of the remnant kidney after donor nephrectomy and albuminuria
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - April 2, 2021 Category: Urology & Nephrology Source Type: research

All-case Japanese post-marketing surveillance of the real-world safety and efficacy of rituximab treatment in patients with refractory nephrotic syndrome
AbstractBackgroundRituximab is conditionally approved in Japan for use in patients with refractory nephrotic syndrome. To meet the conditions of approval, an all-case post-marketing surveillance study was conducted to confirm the real-world safety and efficacy of rituximab in patients of all ages with refractory nephrotic syndrome.MethodsAll patients scheduled to receive rituximab treatment for refractory nephrotic syndrome were eligible to register (registration: August 29, 2014 through April 15, 2016); the planned observation period was 2  years from the initiation of rituximab treatment (intravenous infusion, 375&n...
Source: Clinical and Experimental Nephrology - April 1, 2021 Category: Urology & Nephrology Source Type: research

A randomized double-blinded placebo-controlled clinical trial on protective effects of pentoxifylline on gentamicin nephrotoxicity in infectious patients
AbstractBackground and objectiveRenal toxicity has limited gentamicin use in clinical practice. The aim of the present clinical trial was to assess the possible nephroprotective effects of pentoxifylline (PTX) against gentamicin nephrotoxicity.Materials and methodsA multicenter, randomized, double-blind, placebo-controlled clinical trial was conducted on patients who had the indication for systemic gentamicin for at least 7  days. Sixty people were selected and randomly assigned. For patients in the intervention and control groups, 400 mg PTX sustained release tablet and placebo were given orally three times dail...
Source: Clinical and Experimental Nephrology - April 1, 2021 Category: Urology & Nephrology Source Type: research

Activators of SIRT1 in the kidney and protective effects of SIRT1 during acute kidney injury (AKI) (effect of SIRT1 activators on acute kidney injury)
In this study, we review the mechanisms that mediate the protective effects of SIRT1 on AKI, including SIRT1 activators. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - March 29, 2021 Category: Urology & Nephrology Source Type: research

Correction to: Genome-wide association study identifies new loci for albuminuria in the Japanese population
A correction to this paper has been published: https://doi.org/10.1007/s10157-021-02053-4 (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - March 27, 2021 Category: Urology & Nephrology Source Type: research

Pathology and pathogenic pathways in fabry nephropathy
AbstractBackgroundThe pathophysiology of renal damage in Fabry nephropathy involves a complex biological mechanism. The intracellular deposition globotriaosylceramide (Gb3) is just the first step of the mechanism. The glycolipid deposition occurs in all renal cells (endothelial, epithelial and mesangial cells). It stimulates many biological processes, including cytokine release, epithelial-mesenchymal transdifferentiation, oxidative stress and the remodelling of vascular walls, resulting in subtle initial inflammation and eventually tissue fibrosis. It has been hypothesized that the processes activated by Gb3 deposition ca...
Source: Clinical and Experimental Nephrology - March 26, 2021 Category: Urology & Nephrology Source Type: research

Intra-body dynamics of d -serine reflects the origin of kidney diseases
ConclusionIntra-body dynamics ofd-serine have the potential to predict the origin of kidney diseases. Monitoring ofd-serine may guide specific treatments for the origin of kidney diseases. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - March 25, 2021 Category: Urology & Nephrology Source Type: research

Double hernia in continuous ambulatory peritoneal dialysis patient
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - March 24, 2021 Category: Urology & Nephrology Source Type: research

Segmental membranous nephropathy
AbstractMost cases of membranous nephropathy (MGN) present with global and diffuse distribution of subepithelial deposits. However, segmental MGN, in which there is focal or diffuse segmental subepithelial deposits, are occasionally encountered. The clinical and pathologic significance of segmental MGN is not well understood and thought to be more likely due to either early or resolving phase of the global form of MGN. Several case reports and literature available suggest that it may be a manifestation of secondary causes based on pathologic features such as presence of C1q and mesangial deposits, extra-glomerular deposits...
Source: Clinical and Experimental Nephrology - March 23, 2021 Category: Urology & Nephrology Source Type: research

Anti-pruritic effect of nemolizumab in hemodialysis patients with uremic pruritus: a phase II, randomized, double-blind, placebo-controlled clinical study
ConclusionsIn this phase II study in patients with UP, the primary efficacy parameter was not met. Nemolizumab was generally well tolerated with no clinically significant safety concerns.Clinical trial registrationJAPIC: JapicCTI-152961,https://www.clinicaltrials.jp/cti-user/trial/ShowDirect.jsp?japicId=JapicCTI-152961. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - March 22, 2021 Category: Urology & Nephrology Source Type: research

Reno-protective effects of Phosphodiesterase 5 inhibitors
AbstractThe kidneys are vital organs that play an important role in removing waste materials from the blood, electrolyte balance, blood pressure regulation, and red blood cell genesis. Kidney disease can be caused by various factors, including diabetes, ischemia/reperfusion injury, and nephrotoxic agents. Inflammation and oxidative stress play a key role in the progression and pathogenesis of kidney diseases. Acute kidney injury (AKI) and chronic kidney disease (CKD) are important health problems worldwide, as they are associated with a long-term hospital stay, and increased morbidity and mortality in high-risk patients. C...
Source: Clinical and Experimental Nephrology - March 22, 2021 Category: Urology & Nephrology Source Type: research

Utility of glomerular Gd-IgA1 staining for indistinguishable cases of IgA nephropathy or Alport syndrome
ConclusionGd-IgA1 expression analysis could clearly differentiate these two disorders. This approach can be applied to identify these two diseases showing identical clinical and pathological findings. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - March 20, 2021 Category: Urology & Nephrology Source Type: research

Zinc deficiency: its prevalence and relationship to renal function in Japan
AbstractBackgroundAlthough zinc deficiency is common among dialyzed patients, its prevalence among non-dialyzed subjects and its relationship to renal function remain unclear.MethodsWe selected 816 non-dialyzed subjects (495 males; mean age, 56  ± 18 years) who underwent measurement of serum zinc at Jikei University Hospital between April 2018 and March 2019 using the Standardized Structured Medical Information eXchange2 (SS-MIX2) system, a global standard in Japan that enables collection of structured medical records with automatic data transfer to a registry database system. A serum zinc level o...
Source: Clinical and Experimental Nephrology - March 17, 2021 Category: Urology & Nephrology Source Type: research

Involvement of necroptosis in contrast-induced nephropathy in a rat CKD model
ConclusionThe results suggest that necroptosis of proximal tubular cells contributes to CIN in CKD and that suppression of protective autophagy by pro-necroptotic signaling may also be involved. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - March 16, 2021 Category: Urology & Nephrology Source Type: research

Association of mineral metabolism biomarkers with chronic kidney disease in Chinese adults
ConclusionsOur findings indicate that serum calcium was associated with all-stage CKD risk, whereas the association for inorganic phosphorus and intact parathyroid hormone was significant at advanced stages. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - March 16, 2021 Category: Urology & Nephrology Source Type: research

Living well with kidney disease by patient and care-partner empowerment: kidney health for everyone everywhere
AbstractLiving with chronic kidney disease (CKD) is associated with hardships for patients and their care partners. Empowering patients and their care partners, including family members or friends involved in their care, may help minimize the burden and consequences of CKD-related symptoms to enable life participation. There is a need to broaden the focus on living well with kidney disease and re-engagement in life, including an emphasis on patients being in control. The World Kidney Day (WKD) Joint Steering Committee has declared 2021 the year of “Living Well with Kidney Disease” to increase education and awar...
Source: Clinical and Experimental Nephrology - March 15, 2021 Category: Urology & Nephrology Source Type: research

Correction to: Functional analysis of suspected splicing variants in CLCN5 gene in Dent disease 1
A correction to this paper has been published: https://doi.org/10.1007/s10157-021-02041-8 (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - March 15, 2021 Category: Urology & Nephrology Source Type: research

Efficacy and safety of mycophenolate mofetil in the  treatment for IgA nephropathy: a meta-analysis of randomized controlled trials
ConclusionsMycophenolate mofetil therapy did not differ in reducing proteinuria and Scr in patients with IgAN who had persistent proteinuria, while having fewer Cushing syndrome and diabetes risk and more infection risk. However, larger randomized studies are needed to reveal these results. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - March 12, 2021 Category: Urology & Nephrology Source Type: research

Association between serum uric acid and new onset and progression of chronic kidney disease in a Japanese general population: Iki epidemiological study of atherosclerosis and chronic kidney disease
ConclusionSUA was significantly associated with increased risk for new onset of CKD, but not with progression of CKD among a Japanese general population. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - March 10, 2021 Category: Urology & Nephrology Source Type: research

Do you recommend tonsillectomy for elderly patients with IgA nephropathy?
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - March 5, 2021 Category: Urology & Nephrology Source Type: research

Prediction of microalbuminuria from proteinuria in chronic kidney disease due to non-diabetic lifestyle-related diseases: comparison with diabetes
We examined whether microalbuminuria could be predicted from proteinuria.MethodsThe participants consisted of adults who exhibited a urinary protein-to-creatinine ratio (uPCR) of  
Source: Clinical and Experimental Nephrology - March 3, 2021 Category: Urology & Nephrology Source Type: research

iPSC technology-based regenerative medicine for kidney diseases
AbstractWith few curative treatments for kidney diseases, increasing attention has been paid to regenerative medicine as a new therapeutic option. Recent progress in kidney regeneration using human-induced pluripotent stem cells (hiPSCs) is noteworthy. Based on the knowledge of kidney development, the directed differentiation of hiPSCs into two embryonic kidney progenitors, nephron progenitor cells (NPCs) and ureteric bud (UB), has been established, enabling the generation of nephron and collecting duct organoids. Furthermore, human kidney tissues can be generated from these hiPSC-derived progenitors, in which NPC-derived ...
Source: Clinical and Experimental Nephrology - March 3, 2021 Category: Urology & Nephrology Source Type: research

Correction to: Validation of the diagnostic criteria for IgG4 ‑related kidney disease (IgG4‑RKD) 2011, and proposal of a new 2020 version
A correction to this paper has been published: https://doi.org/10.1007/s10157-021-02040-9 (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - March 3, 2021 Category: Urology & Nephrology Source Type: research

Prevalence and determinants of chronic kidney disease in urban adults ’ populations of northern Cameroon
AbstractBackgroundChronic kidney disease (CKD) is a major health problem with growing prevalence in sub-Saharan Africa.AimAssess the prevalence and determinants of CKD in Garoua and Figuil cities of the North region of Cameroon.MethodsA cross-sectional survey was conducted from January to June 2018 in the two cities, using a multi-level cluster sampling. All adults with low estimated glomerular filtration rate (eGFR) (
Source: Clinical and Experimental Nephrology - March 2, 2021 Category: Urology & Nephrology Source Type: research

PPAR- δ activation reduces cisplatin-induced apoptosis via inhibiting p53/Bax/caspase-3 pathway without modulating autophagy in murine renal proximal tubular cells
ConclusionOur results indicate that GW0742 may serve as a candidate agent to mitigate cisplatin nephrotoxicity via inhibiting the mitochondrial apoptotic pathway considerably depending on PPAR- δ, without modulating autophagy. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - March 1, 2021 Category: Urology & Nephrology Source Type: research

Clinicopathological significance of light chain deposition in IgA nephropathy
ConclusionsThe prevalence of IgA monotypic deposition was extremely low. Clinicopathologically, we could not differentiate patients with monotypic IgA deposition from those with polytypic one and no hematological disorder was documented in patients with monotypic IgA deposition. Whether IgA nephropathy with monotypic IgA deposition and that with polytypic one is the same entity or not, and relation between monotypic IgA deposition and hematological malignancy should be clarified by further investigations. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - March 1, 2021 Category: Urology & Nephrology Source Type: research

Outcome of advanced renal cell carcinoma arising in end-stage renal disease: comparison with sporadic renal cell carcinoma
ConclusionsOutcome of advanced ESRD-RCC was poorer than that of sporadic RCC, but this finding was affected by other prognostic factors. Nevertheless, the study suggested that advanced ESRD-RCC was not an indolent disease. Additionally, patients with a longer duration of dialysis therapy might require careful monitoring. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - February 27, 2021 Category: Urology & Nephrology Source Type: research

Physical activity in patients with pre ‑dialysis chronic kidney disease is associated with decreased renal function
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - February 25, 2021 Category: Urology & Nephrology Source Type: research

Mesangial C3 deposition and serum C3 levels predict renal outcome in IgA nephropathy
AbstractBackgroundComplement activation plays an important role in the pathogenesis of IgA nephropathy (IgAN). We aimed to evaluate the relationship between mesangial C3 deposition and histologic lesions and to investigate the role of mesangial C3 deposition and serum C3 reduction in predicting renal outcome in IgAN children.MethodsWe performed a retrospective cohort study in children with biopsy-proven IgAN. Mesangial C3 deposition (
Source: Clinical and Experimental Nephrology - February 23, 2021 Category: Urology & Nephrology Source Type: research

Renal morphology and function from childhood to adulthood in Turner syndrome
AbstractBackgroundTurner syndrome (TS) is a chromosomal disorder with various complications, including congenital anomaly of the kidney and urinary tract (CAKUT). However, its renal function remains poorly known. Therefore, this study aimed to evaluate renal function in TS of various ages from childhood to adulthood.MethodsWe retrospectively analyzed 63 patients with TS who visited our hospital between 1989 and 2020, examined their renal morphology, and analyzed renal function by calculating the estimated glomerular filtration rate (eGFR) using formulas applicable for Japanese populations.ResultsRenal morphological abnorma...
Source: Clinical and Experimental Nephrology - February 22, 2021 Category: Urology & Nephrology Source Type: research

Kidney biopsy guidebook 2020 in Japan
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - February 19, 2021 Category: Urology & Nephrology Source Type: research

A cross-sectional study in patients with IgA nephropathy of correlations between clinical data and pathological findings at the time of renal biopsy: a Japanese prospective cohort study
ConclusionIn all age cohorts of IgA nephropathy patients, daily proteinuria was correlated with all histological parameters, including both acute and chronic glomerular lesions, and the mesangial score. Independent variables for daily proteinuria were the meangial score, acute histological lesions, and segmental GS on MLRA, whereas the remaining independent variable in the pediatric group was endocapillary hypercellurality. The clinical pathological correlation at the time of biopsy varied depending on the age group. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - February 17, 2021 Category: Urology & Nephrology Source Type: research

Impact of visceral fat area in patients with chronic kidney disease
In this study, we stratified patients with CKD according to VFA category, as well as age, sex, CKD category, hyperglycemia, and diabetes mellitus, and determined the ability of obesity-related indicators (body mass index, waist circumference, subcutaneous fat area, visceral-to-subcutaneous fat ratio) to predict the renal prognosis. Kidney outcomes ( ≥ 50% estimated glomerular filtration rate decline or end-stage kidney disease) were examined in 200 patients with CKD (median follow-up, 12.3 years). On multivariable Cox analysis, an increase in VFA (10-cm2 increase) was significantly associated with kidney out...
Source: Clinical and Experimental Nephrology - February 17, 2021 Category: Urology & Nephrology Source Type: research

Deletion of Alox15 improves kidney dysfunction and inhibits fibrosis by increased PGD 2 in the kidney
ConclusionIncreased PGD2 inAlox15−/− CKD mouse kidneys could inhibit fibrosis, thereby resulting in CKD improvement. Thus,Alox15 inhibition and PGD2 administration may be novel therapeutic targets for CKD. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - February 17, 2021 Category: Urology & Nephrology Source Type: research

Safety and effectiveness of everolimus in maintenance kidney transplant patients in the real-world setting: results from a 2-year post-marketing surveillance study in Japan
AbstractBackgroundData on real-world use of everolimus (EVR) in Japanese maintenance kidney transplant (KTx) patients are limited. This post-marketing surveillance study was conducted to assess the safety and effectiveness of EVR, and identify factors affecting renal impairment.MethodsAdult maintenance KTx patients were enrolled within 14  days of initiating EVR. Patient medical data were collected using electronic data capture case report forms at 6 months, 1, and 2 years after initiating EVR, or at discontinuation.ResultsAll patients receiving EVR in Japan during the surveillance period were enrolled (N&th...
Source: Clinical and Experimental Nephrology - February 11, 2021 Category: Urology & Nephrology Source Type: research

Clinical characteristics of COVID-19 infection in a dialysis center during a nosocomial outbreak
AbstractBackgroundBlood purification therapy is a treatment method, wherein many patients gather in the same space to receive regular treatments, possibly increasing the risk of contracting the coronavirus disease 2019 (COVID-19) through contact, droplet, and aerosol. We experienced a nosocomial outbreak and evaluated the clinical characteristics of COVID-19 infection in patients undergoing blood purification therapy.MethodsWe retrospectively analyzed 28 patients who underwent blood purification therapy at the dialysis center of our hospital from April 2, 2020, to April 29, 2020. Logistic regression analysis was performed ...
Source: Clinical and Experimental Nephrology - February 8, 2021 Category: Urology & Nephrology Source Type: research

Association of serum lncRNA H19 expression with inflammatory and oxidative stress markers and routine biochemical parameters in chronic kidney disease
ConclusionlncRNA H19 expressions were increased in CKD stage 3 –5 and HD patients, and elevated lncRNA H19 expressions were associated with decreased glomerular filtration rate, inflammation, and mineralization markers in these patients. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - February 6, 2021 Category: Urology & Nephrology Source Type: research

Early cardiovascular events and cardiovascular death after renal transplantation: role of pretransplant risk factors
ConclusionThe incidence of CV events and death were predicted by variables associated with myocardial ischemia, a potentially modifiable risk factor. Patients with pretransplantation myocardial ischemia should be considered at a higher risk of developing early CV complications and managed accordingly before, during, and after kidney transplantation. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - January 27, 2021 Category: Urology & Nephrology Source Type: research

Valganciclovir prophylaxis for cytomegalovirus infection in pediatric kidney transplant recipients: a single-center experience
ConclusionsOur preliminary study suggests that the dosage endorsed by The Transplantation Society may be an overdose for Japanese pediatric recipients. Further studies are required to examine the safety and efficacy of VGCV prophylaxis in Japanese pediatric recipients. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - January 27, 2021 Category: Urology & Nephrology Source Type: research

Preservation of kidney function irrelevant of total kidney volume growth rate with tolvaptan treatment in patients with autosomal dominant polycystic kidney disease
AbstractBackgroundTolvaptan slowed the rates of total kidney volume (TKV) growth and renal function decline over a 3-year period in patients with autosomal dominant polycystic kidney disease (ADPKD) enrolled in the Tolvaptan Efficacy and Safety in Management of Autosomal Dominant Polycystic Kidney Disease and Its Outcomes (TEMPO) 3:4 trial (NCT00428948). In this post hoc analysis of Japanese patients from TEMPO 3:4, we evaluated whether the effects of tolvaptan on TKV and on renal function are interrelated.MethodsOne hundred and forty-seven Japanese patients from TEMPO 3:4 were included in this analysis (placebo,n =...
Source: Clinical and Experimental Nephrology - January 20, 2021 Category: Urology & Nephrology Source Type: research

Incidence and risk factors of acute kidney injury, and its effect on mortality among Japanese patients receiving immune check point inhibitors: a single-center observational study
ConclusionsOur finding suggest that pembrolizumab use and liver diseases are associated with a higher risk of ICPi-AKI development, but ICPi-AKI did not affect mortality. Future multi-center studies are needed to develop optimal management and prevention strategies for this complication in patients receiving ICPis. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - January 20, 2021 Category: Urology & Nephrology Source Type: research

Effects of phospholipase A 2 receptor and thrombospondin type-1 domain-containing 7A expression in glomerular basement membranes on treatment response and renal outcome in membranous nephropathy
ConclusionsThe probability of achieving complete remission is high in patients with PLA2R-positive MN for whom the relapse rate was also higher. The overall renal outcome did not differ from PLA2R negative cases. Low incidence of THSD7A-positive MN reduces the possibility of future randomized controlled trials. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - January 18, 2021 Category: Urology & Nephrology Source Type: research

Association between urine pH and risk of contrast-associated acute kidney injury among patients after emergency percutaneous coronary intervention: a V-shape relationship?
AbstractAimWe investigated whether perioperative urine pH was associated with contrast-associated acute kidney injury (CA-AKI) in patients undergoing emergency percutaneous coronary intervention (PCI).MethodsThe study enrolled 1109 consecutive patients undergoing emergency PCI. Patients were divided into three groups based on perioperative urine pH (5.0 –6.0, 6.5– 7.0, 7.5–8.5). The primary endpoint was the development of CA-AKI, defined as an absolute increase ≥ 0.3 mg/dL or a relative increase ≥ 50% from baseline serum creatinine within 48 h after contr...
Source: Clinical and Experimental Nephrology - January 11, 2021 Category: Urology & Nephrology Source Type: research

Correction to: The clinical usage of liposomal amphotericin B in patients receiving renal replacement therapy in Japan: a nationwide observational study
The original article can be found online. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - January 8, 2021 Category: Urology & Nephrology Source Type: research

Hematuria, bone health, and cardiovascular mortality
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - January 7, 2021 Category: Urology & Nephrology Source Type: research