Safety and efficacy of azilsartan in paediatric patients with hypertension: a phase 3, single-arm, open-label, prospective study
AbstractBackgroundAzilsartan is an angiotensin II receptor blocker indicated for the treatment of adult hypertension. A previous single-dose study suggested that azilsartan may also be a promising agent for paediatric hypertension. However, the long-term safety and efficacy of azilsartan in children have not been established.MethodsWe conducted a phase 3, single-arm, open-label, prospective study to evaluate the safety and efficacy of azilsartan in pediatric patients with hypertension. Twenty-seven patients aged 6 –15 years were treated with once-daily azilsartan for 52 weeks. The starting dose was 2.5 ...
Source: Clinical and Experimental Nephrology - November 27, 2021 Category: Urology & Nephrology Source Type: research

Clinicopathological discordance in biopsy-proven nephrosclerosis: a nationwide cross-sectional study of the Japan Renal Biopsy Registry (J-RBR)
ConclusionsPatients with older age, higher eGFR, and lower proteinuria had significantly higher likelihood of being clinically diagnosed with other glomerular disease in patients with biopsy-proven nephrosclerosis. Our findings highlight the heterogeneous clinical phenotypes of nephrosclerosis and suggest the need for continuous improvement of clinical diagnostic accuracy as well as for wider kidney biopsy indications for nephrosclerosis. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - November 23, 2021 Category: Urology & Nephrology Source Type: research

Correction to: Pleiotropic effect of erythropoiesis ‑stimulating agents on circulating endothelial progenitor cells in dialysis patients
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - November 16, 2021 Category: Urology & Nephrology Source Type: research

Gross hematuria after SARS-CoV-2 vaccination: questionnaire survey in Japan
ConclusionThis study clarified the clinical features of gross hematuria after a COVID-19 vaccination. Because there was no obvious progression to severe renal dysfunction, safety of the COVID-19 vaccination is warranted at least in the protocol of inoculation twice. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - November 13, 2021 Category: Urology & Nephrology Source Type: research

Prognostic factors for acute ischemic stroke in patients undergoing hemodialysis
ConclusionsAlong with neurological severity, dialysis vintage, intradialytic hypotension, and diabetic nephropathy could worsen the prognosis of patients with AIS undergoing hemodialysis. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - November 12, 2021 Category: Urology & Nephrology Source Type: research

Calcium channel blocker in patients with chronic kidney disease
ConclusionWe should use different types of CCBs properly depending on their pharmacological effects, such as the strength of antihypertensive effects and the organ protection effects, taking into account the pathophysiology of the patients. In this article, the role and the use of CCBs in CKD patients are reviewed. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - November 8, 2021 Category: Urology & Nephrology Source Type: research

Immune response to SARS-CoV-2 vaccination among renal replacement therapy patients with CKD: a single-center study
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - November 8, 2021 Category: Urology & Nephrology Source Type: research

Calcium channel blocker in patients with chronic kidney disease
ConclusionWe should use different types of CCBs properly depending on their pharmacological effects, such as the strength of antihypertensive effects and the organ protection effects, taking into account the pathophysiology of the patients. In this article, the role and the use of CCBs in CKD patients are reviewed. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - November 8, 2021 Category: Urology & Nephrology Source Type: research

Immune response to SARS-CoV-2 vaccination among renal replacement therapy patients with CKD: a single-center study
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - November 8, 2021 Category: Urology & Nephrology Source Type: research

A digest from evidence-based clinical practice guideline for IgA nephropathy 2020
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - October 21, 2021 Category: Urology & Nephrology Source Type: research

A digest from evidence-based Clinical Practice Guideline for Polycystic Kidney Disease 2020
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - October 21, 2021 Category: Urology & Nephrology Source Type: research

A digest of the evidence-based Clinical Practice Guideline for Rapidly Progressive Glomerulonephritis 2020
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - October 21, 2021 Category: Urology & Nephrology Source Type: research

A digest of the Evidence-Based Clinical Practice Guideline for Nephrotic Syndrome 2020
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - October 21, 2021 Category: Urology & Nephrology Source Type: research

The distribution of eGFR by age in a community-based healthy population: the Japan specific health checkups study (J-SHC study)
This study examined the distribution of estimated glomerular filtration rate (eGFR) values in healthy subjects by age using large-scale cross-sectional data of health check-up participants in Japan.MethodsAmong the 394,180 health check-up participants, 75,217 (19.1%) subjects without hypertension, diabetes, hyperlipidemia, obesity, proteinuria, smoking, past history of cardiovascular diseases, and renal failure/not undergoing dialysis were included in the healthy group. The distribution of eGFR values was determined at each age between 39 and 74  years. Results: in healthy subjects, the mean (± 2 SD rang...
Source: Clinical and Experimental Nephrology - October 20, 2021 Category: Urology & Nephrology Source Type: research

A digest from evidence-based clinical practice guideline for IgA nephropathy 2020
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - October 20, 2021 Category: Urology & Nephrology Source Type: research

Adjuvant heparinization before manipulation of artery reduces early failure in primary arteriovenous fistula for end-stage renal disease patients
ConclusionAdjuvant systemic heparinization therapy just before arterial manipulation reduced early failure of primary AVF without increasing bleeding events. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - October 20, 2021 Category: Urology & Nephrology Source Type: research

Seasonal variation of serum 25-hydroxyvitamin D level in hemodialysis patients in the northernmost island of Japan
ConclusionSerum 25(OH)D has a seasonal variation, being lower in winter than in summer, independent of CKD-MBD treatment including treatment with VDRAs in Japanese hemodialysis patients. The impact of the seasonal variation on risk of vitamin D deficiency and its effect on prognosis remain to be investigated. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - October 20, 2021 Category: Urology & Nephrology Source Type: research

A digest from evidence-based Clinical Practice Guideline for Polycystic Kidney Disease 2020
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - October 20, 2021 Category: Urology & Nephrology Source Type: research

Combined evaluation of plasma B-type natriuretic peptide and urinary liver-type fatty acid-binding protein/creatinine ratio is related to worsening renal function in patients undergoing elective percutaneous coronary intervention
ConclusionsOur results suggest that combined evaluation of plasma BNP and urinary L-FABP/Cr is useful as a predictor of renal dysfunction in CAG/PCI patients. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - October 20, 2021 Category: Urology & Nephrology Source Type: research

Relationship between salt intake and sleep disordered breathing in dialysis patients
AbstractBackgroundThe prevalence of sleep disordered breathing is high in patients with end-stage renal disease. Salt intake is related to the severity of obstructive sleep apnea in patients with resistant hypertension and hyperaldosteronism. We investigated the relationship between salt intake and sleep disordered breathing in patients on maintenance hemodialysis.Patients and methodsWe studied 128 dialysis outpatients (mean age 63  ± 11 years) who were followed at Kokura Daiichi Hospital. We estimated each patient's salt intake using an InBody S10 body composition analyzer and measured the 3% oxy...
Source: Clinical and Experimental Nephrology - October 20, 2021 Category: Urology & Nephrology Source Type: research

The association between frailty and chronic kidney disease; cross-sectional analysis of the Nambu Cohort Study
AbstractBackgroundBoth frailty and chronic kidney disease (CKD) increase with age and share many similarities. Many studies have demonstrated an association between frailty and chronic kidney disease (CKD), but an association with dipstick proteinuria is limited.MethodsThis is the cross-sectional analysis of the Nambu Cohort Study at the beginning of observation. Frailty was diagnosed using Kihon Checklist. Logistic analysis was used to evaluate the association between frailty and CKD or dipstick proteinuria.ResultsAmong a total of 630 outpatients [age, 78 (70 –84) years, men, 50%], the prevalence of patients with pr...
Source: Clinical and Experimental Nephrology - October 20, 2021 Category: Urology & Nephrology Source Type: research

A digest of the evidence-based Clinical Practice Guideline for Rapidly Progressive Glomerulonephritis 2020
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - October 20, 2021 Category: Urology & Nephrology Source Type: research

Post-kidney transplant soluble Klotho levels are determined by pretransplant soluble Klotho levels in both living donors and recipients
ConclusionPretransplant sKl levels in both kidney recipients and living donors are a strong determinant of sKl levels after kidney transplantation. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - October 20, 2021 Category: Urology & Nephrology Source Type: research

A digest of the Evidence-Based Clinical Practice Guideline for Nephrotic Syndrome 2020
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - October 20, 2021 Category: Urology & Nephrology Source Type: research

Cardio-ankle vascular index with renal progression and mortality in high atherosclerosis risk: a prospective cohort study in CORE-Thailand
AbstractBackgroundIncreased arterial stiffness is linked to markers of endothelial dysfunction and vasculopathy such as albuminuria, vascular calcification, left ventricular hypertrophy and cardiovascular (CV) diseases. Studies of arterial stiffness on renal progression are limited.ObjectiveThe study aimed to evaluate the association between high cardio-ankle vascular index (CAVI) and renal endpoint and all-cause mortality in a Thai population with high atherosclerosis risk.MethodsA multicenter prospective cohort study was conducted among subjects with high CV risk or established CV diseases in Thailand. Subjects were divi...
Source: Clinical and Experimental Nephrology - October 13, 2021 Category: Urology & Nephrology Source Type: research

Epidemiology and temporal changes in the prognosis of rapidly progressive glomerulonephritis in Japan: a nationwide 1989 –2015 survey
This study is a continuation of the chronological nationwide survey conducted by the Japan-RPGN working group.MethodsWe examined a total of 2793 RPGN cases registered during four periods (1989 –1998, 1999–2001, 2002–2008, 2009–2011) plus 1386 cases in 2012–2015. As potential prognostic determinants, we investigated the onset period, the clinical severity (CS) grade [classified according to age, serum creatinine (sCr) and C-reactive protein levels, and presence/absence of lung le sions], and causative disease.ResultsThe cumulative overall RPGN patient survival at 24  months kept improving ...
Source: Clinical and Experimental Nephrology - October 13, 2021 Category: Urology & Nephrology Source Type: research

Cardio-ankle vascular index with renal progression and mortality in high atherosclerosis risk: a prospective cohort study in CORE-Thailand
AbstractBackgroundIncreased arterial stiffness is linked to markers of endothelial dysfunction and vasculopathy such as albuminuria, vascular calcification, left ventricular hypertrophy and cardiovascular (CV) diseases. Studies of arterial stiffness on renal progression are limited.ObjectiveThe study aimed to evaluate the association between high cardio-ankle vascular index (CAVI) and renal endpoint and all-cause mortality in a Thai population with high atherosclerosis risk.MethodsA multicenter prospective cohort study was conducted among subjects with high CV risk or established CV diseases in Thailand. Subjects were divi...
Source: Clinical and Experimental Nephrology - October 13, 2021 Category: Urology & Nephrology Source Type: research

Epidemiology and temporal changes in the prognosis of rapidly progressive glomerulonephritis in Japan: a nationwide 1989 –2015 survey
This study is a continuation of the chronological nationwide survey conducted by the Japan-RPGN working group.MethodsWe examined a total of 2793 RPGN cases registered during four periods (1989 –1998, 1999–2001, 2002–2008, 2009–2011) plus 1386 cases in 2012–2015. As potential prognostic determinants, we investigated the onset period, the clinical severity (CS) grade [classified according to age, serum creatinine (sCr) and C-reactive protein levels, and presence/absence of lung le sions], and causative disease.ResultsThe cumulative overall RPGN patient survival at 24  months kept improving ...
Source: Clinical and Experimental Nephrology - October 13, 2021 Category: Urology & Nephrology Source Type: research

Mortality outcomes and clinical background of children on maintenance dialysis without receiving kidney transplantation
ConclusionPatients with severe extrarenal complications or psychomotor retardation tend to be excluded from the indication of transplantation. Their condition becomes fatal because of the complications of long-term dialysis and progression in extrarenal complications. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - October 11, 2021 Category: Urology & Nephrology Source Type: research

List of referees
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - October 6, 2021 Category: Urology & Nephrology Source Type: research

MiR-142-3p ameliorates high glucose-induced renal tubular epithelial cell injury by targeting BOD1
ConclusionMiR-142-3p ameliorates HG-induced renal tubular epithelial cell injury by targeting BOD1. The finding might provide novel insight into the role of miR-142-3p/BOD1 axis in DN treatment. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - September 24, 2021 Category: Urology & Nephrology Source Type: research

VEGF-VEGFR2 inhibitor-associated hyaline occlusive glomerular microangiopathy: a Japanese single-center experience
ConclusionsHistopathological findings in our patients treated with VEGF-VEGFR2 inhibitors were consistent with those observed in the recently described new form of Bmab-associated hyaline occlusive glomerular microangiopathy. This form should be considered in proteinuric cancer patients treated with VEGF-VEGFR2 inhibitors. Discontinuing VEGF-VEGFR2 inhibitors may lead to improvement of glomerular microangiopathy induced by these drugs. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - September 24, 2021 Category: Urology & Nephrology Source Type: research

Natural-derived compounds and their mechanisms in potential autosomal dominant polycystic kidney disease (ADPKD) treatment
ConclusionOverall, this review discusses some of the previously studied and reported natural products and their mechanisms of action which may potentially be redirected into ADPKD. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - September 24, 2021 Category: Urology & Nephrology Source Type: research

Incidence, risk factors and outcome of acute kidney injury  (AKI) in patients with COVID-19
This study aims to evaluate incidence, risk factors and case-fatality rate of AKI in patients with COVID-19.MethodsWe reviewed the health medical records of 307 consecutive patients  with COVID-19 hospitalized at the University Hospital of Modena, Italy.ResultsAKI was diagnosed in 69 out of 307 (22.4%) COVID-19  patients. Stages 1, 2, or 3 AKI accounted for 57.9%, 24.6% and 17.3%, respectively. AKI patients had a mean age of 74.7 ± 9.9 years. These patients showed higher serum levels of the main markers of inflammation and higher rate of severe pneumonia than non-AKI patients. Kidney inj...
Source: Clinical and Experimental Nephrology - September 24, 2021 Category: Urology & Nephrology Source Type: research

COVID-19-induced acute renal tubular injury associated with elevation of serum inflammatory cytokine
ConclusionsLevels of tubular injury markers, especially L-FABP and u β2MG, were significantly associated with IL-6 levels even in patients with no evident AKI. This suggests that L-FABP and uβ2MG could be useful as early detective biomarkers for COVID-19 associated renal injury. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - September 24, 2021 Category: Urology & Nephrology Source Type: research

Impact of polypharmacy on all-cause mortality and hospitalization in incident hemodialysis patients: a cohort study
ConclusionsPP at discharge may be associated with clinical outcomes. However, it remains unclear whether PP is the direct cause of outcomes or is simply a marker for an increased risk of outcomes. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - September 24, 2021 Category: Urology & Nephrology Source Type: research

X-chromosome inactivation patterns in females with Fabry disease examined by both ultra-deep RNA sequencing and methylation-dependent assay
ConclusionWe conclude that skewed XCI could not explain the severity of female Fabry disease and is not the main factor in the onset of various clinical symptoms in females with Fabry disease. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - September 24, 2021 Category: Urology & Nephrology Source Type: research

miR-1968-5p is involved in the pathogenesis of lupus nephritis of NZBWF1 mice by targeting csf1
ConclusionThese results  suggest that miR-1968-5p may be involved in the pathogenesis of lupus nephritis of NZBWF1 mice by targeting csf1. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - September 24, 2021 Category: Urology & Nephrology Source Type: research

Constipation and diabetic kidney disease: The Fukuoka Diabetes Registry
The objective of the present study was to examine the association between constipation and diabetic kidney disease (DKD).MethodsIn total, 4826 Japanese outpatients with type 2 diabetes were classified according to presence or absence of constipation (defecation frequency  
Source: Clinical and Experimental Nephrology - September 24, 2021 Category: Urology & Nephrology Source Type: research

Safety and efficacy of Tolvaptan in real-world patients with autosomal dominant polycystic kidney disease- interim results of SLOW-PKD surveillance
AbstractBackgroundTolvaptan is a vasopressin type 2 receptor antagonist and has been used to treat autosomal dominant polycystic kidney disease (ADPKD) since 2014. There has been limited real-world data on the safety and efficacy of tolvaptan.MethodsThis post-marketing surveillance was conducted to evaluate the long-term safety and the efficacy of tolvaptan in Japanese patients with ADPKD in real-world clinical settings. The baseline characteristics of 1630 patients treated with tolvaptan are reported. Safety analysis comprises evaluation of adverse drug reactions (ADRs). The efficacy evaluation includes percent change in ...
Source: Clinical and Experimental Nephrology - September 24, 2021 Category: Urology & Nephrology Source Type: research

Prevalence of latent tuberculosis infection and its risk factors in Japanese hemodialysis patients
ConclusionsThe prevalence of LTBI is high in Japanese HD patients, especially from the age of 60  years. Older age was a significant risk factor for LTBI, with prediction difficult using other clinical data. Extended HD may mask IGRA results. Therefore, aggressive screening for LTBI is advised in all HD patients regardless of hospital region or type, especially in patients over 60 years of ag e or newly commencing HD. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - September 24, 2021 Category: Urology & Nephrology Source Type: research

Effect on residual kidney function of shared decision-making in selection of dialysis therapy
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - September 24, 2021 Category: Urology & Nephrology Source Type: research

Conversion from intravenous maxacalcitol to oral vitamin D in secondary hyperparathyroidism management
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - September 21, 2021 Category: Urology & Nephrology Source Type: research