Association between urine pH and risk of contrast-associated acute kidney injury among patients after emergency percutaneous coronary intervention: a V-shape relationship?
AbstractAimWe investigated whether perioperative urine pH was associated with contrast-associated acute kidney injury (CA-AKI) in patients undergoing emergency percutaneous coronary intervention (PCI).MethodsThe study enrolled 1109 consecutive patients undergoing emergency PCI. Patients were divided into three groups based on perioperative urine pH (5.0 –6.0, 6.5– 7.0, 7.5–8.5). The primary endpoint was the development of CA-AKI, defined as an absolute increase ≥ 0.3 mg/dL or a relative increase ≥ 50% from baseline serum creatinine within 48 h after contr...
Source: Clinical and Experimental Nephrology - January 11, 2021 Category: Urology & Nephrology Source Type: research

Correction to: The clinical usage of liposomal amphotericin B in patients receiving renal replacement therapy in Japan: a nationwide observational study
The original article can be found online. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - January 8, 2021 Category: Urology & Nephrology Source Type: research

Hematuria, bone health, and cardiovascular mortality
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - January 7, 2021 Category: Urology & Nephrology Source Type: research

Renal prognoses by different target hemoglobin levels achieved by epoetin beta pegol dosing to chronic kidney disease patients with hyporesponsive anemia to erythropoiesis-stimulating agent: a multicenter open-label randomized controlled study
ConclusionsIn NDD-CKD patients with ESA-hyporesponsive renal anemia, the aggressive administration of ESA did not clearly extend kidney survival or result in a significant difference in the incidence of CV events. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - January 7, 2021 Category: Urology & Nephrology Source Type: research

The importance of kidney volume as a marker in the assessment of living-donor kidney transplantation in Japan
AbstractBackgroundIn living kidney transplantation, predicting the risk of end-stage kidney disease in the organ donors though crucial remains to be resolved. Thus, any useful biomarker to predict kidney outcome would be highly desirable to safeguard donors.MethodsThis retrospective study was conducted at Nagoya Daini Red Cross Hospital to confirm whether an increase in preserved kidney volume (PKV) was a predict marker of proteinuria. A change of PKV before and 1  year after kidney donation was measured, and its association with proteinuria 3 years after the donation was analyzed.ResultsA total of 119 kidney don...
Source: Clinical and Experimental Nephrology - January 7, 2021 Category: Urology & Nephrology Source Type: research

Improving hepatitis B vaccination rates for advanced chronic kidney disease patients: a quality improvement initiative
ConclusionsUtilizing a nurse-led approach to hepatitis B vaccination, coupled with EHR-based tools, along with continuous monitoring of performance, helped to improve hepatitis B vaccination among CKD stage 4 and 5 patients. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - January 7, 2021 Category: Urology & Nephrology Source Type: research

Association between serum potassium levels and adverse outcomes in chronic kidney disease: the Fukushima CKD cohort study
AbstractBackgroundSerum potassium disorders, commonly observed in chronic kidney disease (CKD), are reportedly associated with higher mortality, but their impact on renal outcomes is still controversial.MethodsThe present study used the longitudinal data of the Fukushima CKD cohort study to investigate the relationships between hypokalemia and hyperkalemia and adverse outcomes such as renal outcomes and all-cause mortality in Japanese patients with non-dialysis-dependent CKD. The study involved 1330 CKD patients followed-up for 2.8  years. The primary endpoint of the present study was a kidney event, defined as a comb...
Source: Clinical and Experimental Nephrology - January 7, 2021 Category: Urology & Nephrology Source Type: research

Renoprotective effect of GLP-1 receptor agonist, liraglutide, in early-phase diabetic kidney disease in spontaneously diabetic Torii fatty rats
ConclusionsLiraglutide may exert a renoprotective effect via prevention of glomerular endothelial abnormality and preservation of autophagy in early-phase DKD, independent of blood glucose, and blood pressure levels. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - January 6, 2021 Category: Urology & Nephrology Source Type: research

Clinical characteristics of patients with early relapse during B-cell depletion after rituximab treatment for complicated steroid-dependent nephrotic syndrome
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - January 6, 2021 Category: Urology & Nephrology Source Type: research

Clinical and morphologic spectrum of renal involvement in idiopathic hypereosinophilic syndrome
ConclusionsNephrotic syndrome with or without renal insufficiency is the main clinical manifestation. A wide spectrum of renal lesions can be observed in patients with IHES. Eosinophil infiltration into the renal interstitium was common in these patients. Most patients have a good prognosis after glucocorticoid therapy. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - January 4, 2021 Category: Urology & Nephrology Source Type: research

The roles of histone deacetylases in kidney development and disease
AbstractHistone deacetylases (HDACs) are important epigenetic regulators that mediate deacetylation of both histone and non-histone proteins. HDACs, especially class I HDACs, are highly expressed in developing kidney and subject to developmental control. HDACs play an important role in kidney formation, especial nephron progenitor maintenance and differentiation. Several lines of evidence support the critical role of HDACs in the development and progression of various kidney diseases. HDAC inhibitors (HDACis) are very effective in the prevention and treatment of kidney diseases (including kidney cancer). A better understan...
Source: Clinical and Experimental Nephrology - January 4, 2021 Category: Urology & Nephrology Source Type: research

Impact of water consumption on renal function in the general population: a cross-sectional analysis of KNHANES data (2008 –2017)
AbstractBackgroundThe renoprotective effect of water intake remains unclear. We aimed to investigate the relationship between water intake and renal impairment in the Korean general population, focusing on individual differences in body fluid distribution and risk of chronic dehydration.MethodsWe conducted a cross-sectional analysis of the 2008 –2017 Korea National Health and Nutrition Examination Survey (KNHANES). Adult participants who had body weight and serum creatinine data and had answered 24-h recall nutritional survey were included. Four water intake groups were defined by daily total water intake per body weight: lowest (
Source: Clinical and Experimental Nephrology - January 4, 2021 Category: Urology & Nephrology Source Type: research

Safety and utility of the alpha-replacer for treatment of intraluminal obstruction of peritoneal catheters by fibrin clots
ConclusionOur results suggest that treatment with the alpha-replacer is a safe and effective treatment option for intraluminal obstruction of PD catheters by fibrin clots. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - January 4, 2021 Category: Urology & Nephrology Source Type: research

Role and expression of non-classical human leukocyte antigen-G in renal transplanted allografts
ConclusionUnlike immunosuppressants, acquired HLA-G expression might confer long-term renal preservation effects in renal transplanted allografts. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - January 4, 2021 Category: Urology & Nephrology Source Type: research

Elevation of creatine kinase is associated with acute kidney injury in hospitalized patients infected with seasonal influenza virus
We examined the association between the incidence of AKI and clinical parameters using Spearman ’s correlation analyses, receiver-operating characteristic (ROC) curves, and multivariate logistic regression analyses.ResultsOf 123 patients, AKI developed in 46 patients (37.4%). Patients with AKI showed higher serum creatine kinase (CK,P 
Source: Clinical and Experimental Nephrology - January 4, 2021 Category: Urology & Nephrology Source Type: research

Hypokalemia in Patients with COVID-19
ConclusionsHypokalemia was a frequent disorder in subjects with COVID-19. Female sex and diuretic therapy were identified as risk factors for low serum potassium levels. Hypokalemia was unrelated to ICU transfer and death in this cohort of patients. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - January 4, 2021 Category: Urology & Nephrology Source Type: research

Validation of the diagnostic criteria for IgG4-related kidney disease (IgG4-RKD) 2011, and proposal of a new 2020 version
ConclusionThe revised version has considerably improved test performance after addition of the new extra-renal organ item (imaging and clinical findings). (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - January 4, 2021 Category: Urology & Nephrology Source Type: research

Relationship between serum lipid concentrations and impaired renal function in patients with chronic kidney disease: the Fukuoka Kidney Disease Registry Study
ConclusionPatients with advanced CKD stages are more likely to have hypertriglyceridemia and hypo-HDL-cholesterolemia than those in early stages. This type of lipid profile may represent a risk factor for ASCVD in patients with CKD. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - January 4, 2021 Category: Urology & Nephrology Source Type: research

Renal capsular vein thrombosis
AbstractA 30-year-old pregnant woman developed postpartum HELLP syndrome. Abdominal computed tomography revealed a high-density vessel structure in contact with the right kidney and connected to the right ovarian vein, suggesting thrombosis in the right inferior renal capsular vein (RCV). RCV thrombosis is a rare thrombotic disorder in postpartum women, and hypercoagulability related to the pregnancy complications may be the predisposing factor. The potential risk for pulmonary embolism in the rare pregnancy-related thrombosis should be recognized. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - January 4, 2021 Category: Urology & Nephrology Source Type: research

Clinical and histopathological features of acute kidney injury in adult-onset minimal change nephrotic syndrome
ConclusionThese results indicate that urinary protein, increased body weight, and interstitial edema score are important information for predicting development of AKI in adult-onset MCNS patients. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - November 28, 2020 Category: Urology & Nephrology Source Type: research

The immunohistochemical expression of von Willebrand factor, T-cadherin, and Caveolin-1 is increased in kidney allograft biopsies with antibody-mediated injury
This study analyzed the expression of Caveolin-1 (Cav), von Willebrand factor (Vwf), and T-cadherin (Cad) in kidney biopsies and their association with antibody-mediated injury.MethodsIn this retrospective study, 114 cases with antibody-mediated changes (Banff, 2020) and 72 with interstitial fibrosis/tubular atrophy were selected. IHC for Cav, Vwf and Cad was performed and evaluated according to their qualitative expression in peritubular capillaries. The cases were grouped according to the presence of microvascular inflammation (MVI), donor-specific antibodies (DSA), C4d positivity and antibody-mediated rejection (AMR). A...
Source: Clinical and Experimental Nephrology - November 26, 2020 Category: Urology & Nephrology Source Type: research

Impact of atrial fibrillation on the risk of ischemic stroke in patients on hemodialysis: BOREAS-HD3 Study
This study was designed as a multicenter cohort study. HD patients (n = 1,067) were enrolled from 22 institutes in January 2009 and followed up for 3 years. Patients with missing data (n = 196) or kidney transplantation (n = 4) were excluded, and 867 patients contributed to the analysis of the risk of new-onset of ischemic stroke.ResultsAt baseline, AF was observed in 123 patients (14.2%, AF group) and not in the others (n = 744: 85.8%, non-AF group). During a follow-up period of 31.3 months, the cumulative incidence rate for ischemic stroke was significantl...
Source: Clinical and Experimental Nephrology - November 18, 2020 Category: Urology & Nephrology Source Type: research

Peritoneal dialysis (PD) technique training: what features influence learning time?
ConclusionNumber of PD training sessions depends on the patient ’s age and comorbidities, but is not related to social, educational or employment status. Prolonged training duration was a statistically significant predictor of higher peritonitis risk, but it was not related to shorter permanence in PD in our series. Identifying these patients since the trainin g period would be useful to adapt training schedule as an early prevention strategy to minimize the risk of peritonitis and plan a preemptive retraining. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - November 12, 2020 Category: Urology & Nephrology Source Type: research

The clinical usage of liposomal amphotericin B in patients receiving renal replacement therapy in Japan: a nationwide observational study
ConclusionL-AMB may be used for patients undergoing maintenance HD or CRRT without any dosing, duration, or interval adjustments. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - November 11, 2020 Category: Urology & Nephrology Source Type: research

Effect of tolvaptan on renal involvement in patients with autosomal dominant polycystic kidney disease according to different gene mutations
We examined the decline in renal function and %TKV by computed tomography and analyzed the gene mutation. Patients were classified into the following four groups according to gene mutation type:PKD1-truncated,PKD1-non-truncated,PKD2, and mutation not found. Patients were treated with tolvaptan, and the effects of tolvaptan were analyzed according to the gene mutation type.ResultsPatients (age: 52.3  ± 11.2 years) were administered tolvaptan at a dose of 45 or 60 mg. No variation was observed in the annual changes in eGFR (%eGFR) (before: − 10.5% ± 13.9%, after: &min...
Source: Clinical and Experimental Nephrology - November 3, 2020 Category: Urology & Nephrology Source Type: research

Preoperative CT volumetry of estimated residual kidney for prediction of postoperative chronic kidney disease in patients with renal cell carcinoma
ConclusionUsing these predictive factors, we may determine patients with high risk for CKD who require an early intervention of renal protective treatment. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - October 30, 2020 Category: Urology & Nephrology Source Type: research

InsKid —a new mobile application (app) that measures the infundibulopelvic angle before retrograde intrarenal surgery more reliably than does other approaches: pilot study
ConclusionThis new application reproduces the intraoperative aspects of the PCS more clearly than the other methods and also provides an easy solution for clearly defining the IPA without relying on the central axes. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - October 29, 2020 Category: Urology & Nephrology Source Type: research

A phase 3 multicenter open-label maintenance study to investigate the long-term safety of sodium zirconium cyclosilicate in Japanese subjects with hyperkalemia
ConclusionAfter a year of exposure, SZC treatment was well tolerated by Japanese patients and potassium levels were well controlled. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - October 24, 2020 Category: Urology & Nephrology Source Type: research

Adult-onset minimal change disease: the significance of histological chronic changes for clinical presentation and outcome
ConclusionStandardized grading of chronicity was a predictor of kidney survival and disease relapse and was related to AKI. Older patients with severe nephrotic syndrome and with increased chronicity score could represent a high-risk category. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - October 22, 2020 Category: Urology & Nephrology Source Type: research

Relationships between cystatin C- and creatinine-based eGFR in Japanese rural community- dwelling older adults with sarcopenia
We examined the relationships between cystatin C-based GFR (eGFRcys), creatinine-based GFR (eGFRcre), their ratio (eGFRcys/eGFRcre) and sarcopenia in community-dwelling older adults in Japan. This cross-sectional study included 302 men aged 73.9  ± 6.2 years and 647 women aged 72.9 ± 5.8 years from a rural area in Hyogo Prefecture, Japan. eGFRcys and eGFRcre were simultaneously measured, and sarcopenia based on the Asia Working Group for Sarcopenia (AWGS) 2019 criteria was evaluated.ResultseGFRcys and the eGFRcys/eGFRcre ratio were significantly correlated with grip power...
Source: Clinical and Experimental Nephrology - October 22, 2020 Category: Urology & Nephrology Source Type: research

List of referees
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - October 20, 2020 Category: Urology & Nephrology Source Type: research

Multiple renal abscesses due to Proteus mirabilis
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - October 18, 2020 Category: Urology & Nephrology Source Type: research

Fact-finding survey on health literacy among Japanese predialysis chronic kidney disease patients: a multi-institutional cross-sectional study
AbstractBackgroundLow health literacy (HL) has been associated with poor chronic disease management and adverse outcomes. However, reports on HL in predialysis chronic kidney disease (CKD) patients are limited in Japan.MethodsFrom August 2019 to February 2020, the European Health Literacy Survey (Japanese version) and a patient background survey (highest level of education, income, social activities, and exercise habit) were conducted on adult predialysis CKD patients. We compared clinical parameters in two groups according to the average HL score of a healthy Japanese population. In addition, a median value of 42 items wa...
Source: Clinical and Experimental Nephrology - October 15, 2020 Category: Urology & Nephrology Source Type: research

Inpatient educational program delays the need for dialysis in patients with chronic kidney disease stage G5
ConclusionAn IEP may delay the start of dialysis in patients with end-stage kidney disease, contribute to better preparation of vascular access placement and the smoother start of dialysis. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - October 11, 2020 Category: Urology & Nephrology Source Type: research

Demographic, clinical and laboratory characteristics of rapidly progressive glomerulonephritis in Turkey: Turkish Society of Nephrology-Glomerular Diseases (TSN-GOLD) Working Group
ConclusionsOur data are generally compatible with the literature. Advanced chronic histopathological findings were prominent in the biopsy of 21 patients. Early biopsy should be performed to confirm the diagnosis of RPGN and to avoid unnecessary intensive immunosuppressive therapy. In addition to the treatments applied, detailed data, including patient and renal survival, are needed. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - October 11, 2020 Category: Urology & Nephrology Source Type: research

Predictive factors and management of urinary tract infections after kidney transplantation: a retrospective cohort study
ConclusionsKidney transplant recipients with prolonged postoperative malnutrition, posttransplant voiding dysfunction and/or urinary storage disorder had an increased risk of UTI. Bladder function tests, such as uroflowmetry, postvoid residual urine tests, and urodynamic tests, were needed to predict UTI. For patients with malnutrition, care should be taken to ensure sufficient calorie intake. Kidney transplant recipients who develop UTI should be treated as complicated UTI patients. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - October 8, 2020 Category: Urology & Nephrology Source Type: research

Efficacy of continuous erythropoietin receptor activator for end-stage renal disease patients with renal anemia before and after peritoneal dialysis initiation
ConclusionTreatment with CERA prior to and during the peritoneal dialysis initiation achieved fairly good anemia management in patients with and without diabetes. The CERA dosage could be reduced in patients without diabetes after dialysis initiation. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - October 5, 2020 Category: Urology & Nephrology Source Type: research

Association of neutrophil-to-lymphocyte ratio and risk of cardiovascular or all-cause mortality in chronic kidney disease: a meta-analysis
AbstractBackgroundIt is currently controversial whether neutrophil-to-lymphocyte ratio (NLR) has a prognostic role in patients with chronic kidney disease (CKD). We aimed to investigate whether NLR was an independent predictor of cardiovascular or all-cause mortality in CKD patients with or without hemodialysis by performing a meta-analysis.MethodsPubmed, Embase, and Cochrane Library databases are systematically searched for relevant literature that investigated NLR and subsequent cardiovascular or all-cause mortality risk in CKD with or without dialysis. Pooled hazard risk (HR) with 95% confidence interval (CI) was calcul...
Source: Clinical and Experimental Nephrology - October 5, 2020 Category: Urology & Nephrology Source Type: research

Efficacy of once-daily cyclosporine in Japanese children with steroid-dependent minimal change nephrotic syndrome
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - October 5, 2020 Category: Urology & Nephrology Source Type: research

Screening of renal anomalies in first-degree relatives of children diagnosed with non-syndromic congenital anomalies of kidney and urinary tract
ConclusionSignificant renal anomalies were identified in first-degree relatives of children with non-syndromic CAKUT and hence, attempts must be made to screen the family members of children with non-syndromic CAKUT. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - October 5, 2020 Category: Urology & Nephrology Source Type: research

Apararenone in patients with diabetic nephropathy: results of a randomized, double-blind, placebo-controlled phase 2 dose –response study and open-label extension study
AbstractBackgroundWe investigated the efficacy and safety of apararenone (MT-3995), a non-steroidal compound with mineralocorticoid receptor agonist activity, in patients with stage 2 diabetic nephropathy (DN).MethodsThe study had two parts: a dose –response, parallel-group, randomized, double-blind, placebo-controlled, multicenter, phase 2, 24-week study and an open-label, uncontrolled, 28-week extension study. Primary and secondary endpoints were the 24-week percent change from baseline in urine albumin to creatine ratio (UACR) and 24- and 52-week UACR remission rates. Safety parameters were changes from baseline i...
Source: Clinical and Experimental Nephrology - September 23, 2020 Category: Urology & Nephrology Source Type: research

Higher cardiovascular mortality in men with persistent dipstick hematuria
ConclusionsIn men, persistent dipstick hematuria is a significantly risk factor of all-cause mortality, in particular cardiovascular death among general screening participants. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - September 21, 2020 Category: Urology & Nephrology Source Type: research

Glucocorticoid treatment is associated with ICU-acquired hypernatremia: a nested case –control study
ConclusionIn this nested case –control study, we demonstrated a significant association between IAH and high-dose glucocorticoid with significant duration–response effects. Serum sodium concentrations should be monitored carefully in critically ill patients administered prolonged high-dose glucocorticoid. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - September 21, 2020 Category: Urology & Nephrology Source Type: research

Initial responsiveness to darbepoetin alfa and its contributing factors in non-dialysis chronic kidney disease patients in Japan
This study aimed to investigate the initial responsiveness to darbepoetin alfa (DA) and its contributing factors using the data from the BRIGHTEN.MethodsOf 1980 patients enrolled at 168 facilities, 1695 were included in this analysis [285 patients were excluded mainly due to lack of hemoglobin (Hb) values]. The initial ESA response index (iEResI) was defined as a ratio of Hb changes over 12  weeks after DA administration per weight-adjusted total DA dose and contributing factors to iEResI were analyzed.ResultsThe mean age was 70  ± 12 years (male 58.8%; diabetic nephropathy 27.6%). The median...
Source: Clinical and Experimental Nephrology - September 18, 2020 Category: Urology & Nephrology Source Type: research

Podocyte sphingomyelin phosphodiesterase acid-like 3b decreases among children with idiopathic nephrotic syndrome
ConclusionThe expression of SMPDL-3b on podocytes is specifically decreased in paediatric-onset INS and its urinary excretion level reflects such conditions. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - September 17, 2020 Category: Urology & Nephrology Source Type: research

Serum levels of galactose-deficient IgA1 in Chinese children with IgA nephropathy, IgA vasculitis with nephritis, and IgA vasculitis
AbstractObjectiveIgA nephropathy (IgAN) and IgA vasculitis with nephritis (IgAV-N) are related diseases. Galactose-deficient IgA1 (Gd-IgA1) plays an important role in the pathology of IgAV-N and IgAN, so we aim to compare the serum levels of Gd-IgA1 in Chinese pediatric patients with IgAN, IgAV-N, and IgAV.MethodsWe retrospectively enrolled 52 patients with IgAN, 57 patients with IgAV-N, 26 patients with IgAV, and 40 healthy children. The serum levels of Gd-IgA1 were measured at the time of biopsy using a lectin-based ELISA method.ResultsGd-IgA1 levels in IgAV-N patients and IgAN patients were higher than in healthy contro...
Source: Clinical and Experimental Nephrology - September 14, 2020 Category: Urology & Nephrology Source Type: research

Serum uromodulin is a novel renal function marker in the Japanese population
ConclusionsThe serum uromodulin measurement could be a useful biomarker for identification of patients with early deterioration of kidney function. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - September 10, 2020 Category: Urology & Nephrology Source Type: research

Dental caries status is associated with arteriosclerosis in patients on hemodialysis
ConclusionThese findings suggest that worse dental caries status could be associated with arteriosclerosis among patients on hemodialysis, which may indirectly affect the prognosis of arteriosclerosis in these patients. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - September 10, 2020 Category: Urology & Nephrology Source Type: research

Zebra bodies without Fabry disease or hydroxychloroquine
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - September 10, 2020 Category: Urology & Nephrology Source Type: research

Intravenous administration of Streptococcus mutans induces IgA nephropathy-like lesions
AbstractBackgroundIgA nephropathy (IgAN) is one of the most frequently occurring types of chronic glomerulonephritis. Previous analyses have revealed that a major pathogen of dental caries,Streptococcus mutans [which expresses collagen-binding protein (Cnm) on its surface], is involved in the pathogenesis of IgAN.MethodsCnm-positiveS. mutans isolated from a patient with IgAN was intravenously administered to specific pathogen-free Sprague –Dawley rats to evaluate their kidney conditions.ResultsThe urinary protein level of theS. mutans group reached a plateau at 30  days, with increased numbers of mesangial cells...
Source: Clinical and Experimental Nephrology - September 8, 2020 Category: Urology & Nephrology Source Type: research