E-cadherin and periostin in early detection and progression of diabetic nephropathy: epithelial-to-mesenchymal transition
AbstractBackgroundDiabetic nephropathy (DN) is a severe complication of diabetes mellitus (DM). Many mechanisms are involved in its development; one of these mechanisms is epithelial-to-mesenchymal transition (EMT). During EMT, losing of the epithelial biomarkers like E-cadherin and increasing of mesenchymal biomarkers like periostin are very characteristic.MethodsThe study included 19 healthy controls and 71 DN patients categorized according to their urinary albumin-to-creatinine ratio (UACR) into 19 normoalbuminuric (UACR    300 mg/g) patients. Fasting plasma glucose (FPG), glycated hemoglobin (HbA1C%)...
Source: Clinical and Experimental Nephrology - May 18, 2019 Category: Urology & Nephrology Source Type: research

Huge internal iliac artery aneurysm and post-renal AKI
We report a rare case of a huge internal iliac artery aneurysm (IAA) complicated by post-renal acute kidney injury. Huge internal IAA should be considered for one of differential diagnoses for post-renal acute kidney injury. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - May 15, 2019 Category: Urology & Nephrology Source Type: research

Impact of distance between donor and recipient hospitals on cadaveric kidney transplantation outcomes
AbstractBackgroundThe impact of distance between donor and recipient hospitals on outcomes in cadaveric kidney transplantations is unknown. We investigated the association between inter-hospital distance and outcomes in cadaveric kidney transplantations in Japan.MethodsWe retrospectively analyzed 363 cadaveric kidney transplantations between 2002 and 2017 in Japan. Inter-hospital distance, graft transport time, total ischemic time (TIT), and graft survival were compared between our hospital and national transplantation cohort in Japan. Estimated glomerular filtration rate (eGFR) 1  month and 1 year after transpla...
Source: Clinical and Experimental Nephrology - May 11, 2019 Category: Urology & Nephrology Source Type: research

Gap acidosis except lactic acidosis develops and progresses during chronic kidney disease stage G5
AbstractBackgroundGap acidosis, a type of metabolic acidosis caused by titratable acid accumulation, participates in CKD progression. It was found at all the stages of chronic kidney disease (CKD), whereas the kidney was believed to preserve its ability to excrete titratable acid until renal function is impaired severely.MethodsSerum concentrations of lactate (Lac) and the other usually unmeasured anions (OUA) were separately examined using 420 records of blood gas analysis performed simultaneously with serum chemistry at a general hospital.ResultsBetween the records grouped by the CKD stage, Lac was generally higher in th...
Source: Clinical and Experimental Nephrology - May 6, 2019 Category: Urology & Nephrology Source Type: research

Impact of acute kidney injury at the onset of idiopathic nephrotic syndrome in Japanese children
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - May 4, 2019 Category: Urology & Nephrology Source Type: research

A quantitative approach to intravenous fluid therapy in the syndrome of inappropriate antidiuretic hormone secretion
ConclusionThe presented model facilitates rational intravenous fluid therapy in SIADH patients, and provides a valuable addition to existing prediction models. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - May 2, 2019 Category: Urology & Nephrology Source Type: research

A simple risk score model for predicting contrast-induced nephropathy after coronary angiography in patients with diabetes
ConclusionOur data suggest that the new simple risk score might be a good tool for predicting CIN in patients with DM undergoing CAG/PCI. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - May 2, 2019 Category: Urology & Nephrology Source Type: research

The effects of a participatory structured group educational program on the development of CKD: a population-based study
ConclusionsOur SGE program showed the beneficial effects of preventing the development of CKD, independent of classical factors. The type of SGE program that is more effective for preventing development of CKD should be investigated in a long-term analysis. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - April 27, 2019 Category: Urology & Nephrology Source Type: research

The interaction between post-transplant anemia and allograft function in kidney transplantation: The Japan Academic Consortium of Kidney Transplantation-II study
AbstractBackgroundThe interaction between post-transplant anemia (PTA) and allograft function in kidney transplantation has not been evaluated directly. PTA, defined by WHO/AST criteria, was investigated in 1307 adult kidney transplant recipients between 2000 and 2015 (median follow-up, 7  years).MethodsWe investigated the impact of hemoglobin (Hb) on graft failure (non-censored for death) and their interactions, time-dependent Cox model, and subgroup analysis were used.ResultsPTA prevalence was 43.6% at 7  years and varied according to allograft function, recipient sex, and follow-up period. Decreased Hb conside...
Source: Clinical and Experimental Nephrology - April 24, 2019 Category: Urology & Nephrology Source Type: research

Correction to: Clinical characteristics and genetic backgrounds of Japanese patients with atypical hemolytic uremic syndrome
The original article can be found online (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - April 23, 2019 Category: Urology & Nephrology Source Type: research

Instrument errors of an analyzer influence acid –base assessment
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - April 15, 2019 Category: Urology & Nephrology Source Type: research

Mutation analyses by next-generation sequencing and multiplex ligation-dependent probe amplification in Japanese autosomal dominant polycystic kidney disease patients
ConclusionAlthough NGS is useful, we propose the addition of Sanger sequencing for exon 1 ofPKD1 and MLPA as indispensable for identifying mutations not detected by NGS. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - April 15, 2019 Category: Urology & Nephrology Source Type: research

Analysis of 2897 hospitalization events for patients with chronic kidney disease: results from CKD-JAC study
ConclusionsPatients with chronic kidney disease and diabetes are highly vulnerable to hospitalization for a variety of diseases. These descriptive data can be valuable in predicting the prognosis of patients with chronic kidney disease. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - April 9, 2019 Category: Urology & Nephrology Source Type: research

Clinical and histological features and therapeutic strategies for IgA nephropathy
AbstractChronic glomerulonephritis is the second most common reason, after diabetic nephropathy, for initiation of dialysis in Japan and IgA nephropathy (IgAN) is the most prevalent form of chronic glomerulonephritis. In the half century since IgAN was initially reported, our understanding of the long-term prognosis, clinical and histological features, pathogenesis of onset and progression, risk factors for progression, and appropriate treatment under different clinical and histological conditions, has steadily increased. Strong experimental and clinical evidence,the Clinical Practice Guidelines for IgA Nephropathy in Japa...
Source: Clinical and Experimental Nephrology - April 9, 2019 Category: Urology & Nephrology Source Type: research

Detailed clinical manifestations at onset and prognosis of neonatal-onset Denys –Drash syndrome and congenital nephrotic syndrome of the Finnish type
AbstractBackgroundNeonatal-onset Denys–Drash syndrome (NODDS) is a distinctive clinical entity and has a poor renal and life outcome. Early diagnosis of NODDS is important for managing disorders of sexual development and determining assigned gender. Although patients with NODDS and congenital nephrotic syndrome of the Finnish type (CNF) present with nephrotic syndrome in neonatal life or infancy, the clinical course of NODDS and factors distinguishing these diseases at onset is unknown.MethodsWe performed a retrospective cohort study of patients with NODDS and CNF between 1997 and 2017. Patients with nephrotic syndro...
Source: Clinical and Experimental Nephrology - April 8, 2019 Category: Urology & Nephrology Source Type: research

Triglyceride –glucose index is a predictor of incident chronic kidney disease: a population-based longitudinal study
ConclusionThis study revealed that TyG index can be a predictor of incident CKD. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - April 6, 2019 Category: Urology & Nephrology Source Type: research

Efficacy and safety of evocalcet in Japanese peritoneal dialysis patients
ConclusionThis study shows the long-term efficacy and safety of evocalcet when orally administered to PD patients with SHPT once daily.Clinical trial registrationClinicalTrials.gov: NCT02549417,https://clinicaltrials.gov/ct2/show/NCT02549417; JAPIC: JapicCTI-153016,http://www.clinicaltrials.jp/user/showCteDetailE.jsp?japicId=JapicCTI-153016. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - April 6, 2019 Category: Urology & Nephrology Source Type: research

Genetic risk score raises the risk of incidence of chronic kidney disease in Korean general population-based cohort
AbstractBackgroundChronic kidney disease (CKD) is a common disease, affecting about 10% of the general population. The genetic component about CKD incidence in Asian population is not well known. The aim of the study is to find the genetic loci associated with incident CKD and to figure out the effect of genetic variation on the development of CKD.MethodsWe conducted a genome-wide association (GWA) study regarding the development of CKD based on two population-based cohorts of Korean Genome Epidemiology Study. 3617 Koreans from two different cohorts, aged 40 –49 years without CKD at initial visit, were included ...
Source: Clinical and Experimental Nephrology - April 6, 2019 Category: Urology & Nephrology Source Type: research

Urine exosomal ceruloplasmin: a potential early biomarker of underlying kidney disease
ConclusionWe propose that urine exosomal CP, observed to increase prior to proteinuria, makes it a potential urinary biomarker to diagnose early kidney disease. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - April 6, 2019 Category: Urology & Nephrology Source Type: research

N -Acetyl-seryl-aspartyl-lysyl-proline is a potential biomarker of renal function in normoalbuminuric diabetic patients with eGFR  ≥ 30 ml/min/1.73 m 2
AbstractBackgroundA biomarker, by which we can predict alterations of renal function in normoalbuminuric diabetic patients, is not available. Here, we report that endogenous anti-fibrotic peptideN-acetyl-seryl-aspartyl-lysyl-proline (AcSDKP) represents a potential biomarker to predict alterations in eGFR in normoalbuminuric diabetic patients.MethodsWe analyzed 21 normoalbuminuric diabetic patients with eGFR  ≥ 30 ml/min/1.73 m2 and measured AcSDKP levels in first morning void urine. We divided patients into two groups based on the median values: low or high urinary AcSDKP groups (uAcSDKP/Crlow or...
Source: Clinical and Experimental Nephrology - April 4, 2019 Category: Urology & Nephrology Source Type: research

Factors affecting inadequate response to HBV vaccine in hemodialysis patients: northeast anatolia survey with six hemodialysis centers
AbstractBackgroundIn hemodialysis patients Hepatitis B virus (HBV) infection is one of the problems. Because of HBV vaccine response is lower than in the general population, in this study it is aimed to determine the factors that may cause inadequate HBV vaccine response in hemodialysis patients.MethodsIn study, HBsAg, anti-HBs, anti-HBc IgG data belonging to 278 patients were obtained from file and computer records. It was seen that seronegative cases had been given recombinant HBV vaccine. Anti-HBs titers were monitored 1  month after vaccination was completed. According to this, the patients are divided into two gr...
Source: Clinical and Experimental Nephrology - March 26, 2019 Category: Urology & Nephrology Source Type: research

Peritoneal protein clearance predicts mortality in peritoneal dialysis patients
ConclusionsBaseline peritoneal protein clearance is an independent predictor of all-cause mortality in incident PD patients. Routine measurement of peritoneal protein clearance may facilitate patient risk stratification. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - March 26, 2019 Category: Urology & Nephrology Source Type: research

Interleukin-33/ST2 signaling contributes to the severity of hemolytic uremic syndrome induced by enterohemorrhagic Escherichia coli
ConclusionsOur results indicate that IL-33 contributes to the severity of EHEC-induced HUS. Serum sST2 level in HUS patients correlated with disease activity, which suggests its potential role as a marker for disease activity and development of encephalopathy in patients with EHEC-induced HUS. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - March 26, 2019 Category: Urology & Nephrology Source Type: research

Hydrochlorothiazide ameliorates polyuria caused by tolvaptan treatment of polycystic kidney disease in PCK rats
ConclusionHCTZ reduces tolvaptan-induced polyuria without altering its beneficial effects on PKD. This novel therapeutic combination could potentially lead to better PKD treatments and improved quality of life for the affected patients. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - March 26, 2019 Category: Urology & Nephrology Source Type: research

Glomerular basement membrane duplication is a predictor of the prognosis of diabetic nephropathy in patients with type 2 diabetes
ConclusionWe newly identified GBM-DP as a strong prognostic predictor in DN patients. Further study is needed to clarify the pathogenic mechanism of GBM-DP in DN. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - March 26, 2019 Category: Urology & Nephrology Source Type: research

Chronological renal resistive index increases related to atherosclerotic factors, and effect of renin-angiotensin system inhibitors
ConclusionsThis study demonstrated that the elevation of RI was related to DM, eGFR, high LDL, and the use of RAS-Is. In particular, RAS-Is could contribute towards suppressing the elevation of RI in CKD patients and towards preventing the development of renal failure in CKD patients. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - March 26, 2019 Category: Urology & Nephrology Source Type: research

Role of the putative PKC phosphorylation sites of the type IIc sodium-dependent phosphate transporter in parathyroid hormone regulation
ConclusionsThe present study suggests that acute regulation of NaPi-IIc protein by PTH is involved in the inactivation of Na+-dependent Pi cotransporter activity and that phosphorylation of the transporter is involved in the rapid modification. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - March 21, 2019 Category: Urology & Nephrology Source Type: research

A retrospective analysis of children with Henoch –Schonlein purpura and re-evaluation of renal pathologies using Oxford classification
ConclusionThe long-term morbidity of HSP is predominantly attributed to renal involvement. Patients with HSP, who have a high risk to develop nephritis, could be followed for longer periods of time. The Oxford classification is useful in predicting long-term outcomes of HSPN. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - March 20, 2019 Category: Urology & Nephrology Source Type: research

Effects of lactulose on renal function and gut microbiota in adenine-induced chronic kidney disease rats
ConclusionLactulose modifies gut microbiota and ameliorates CKD progression by suppressing uremic toxin production. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - March 20, 2019 Category: Urology & Nephrology Source Type: research

Negative impact of proteinuria on circulating myeloid dendritic cells
AbstractBackgroundA decrease in absolute numbers (abs.) of circulating dendritic cells (DCs) and recruitment into target organs has been reported, but whether the level of proteinuria associates with circulating DC abs. has not been clarified.MethodsWe conducted a cross-sectional study of 210 patients with kidney disease aged 21 –96 years who were admitted to our hospital for kidney biopsy in 2007–2010. For accuracy, the level of proteinuria was thoroughly measured by 24-h urine collection from patients in their admitted condition. The abs. of total DCs (tDCs), myeloid DCs (mDCs) and plasmacytoid DCs (pDCs...
Source: Clinical and Experimental Nephrology - March 16, 2019 Category: Urology & Nephrology Source Type: research

Metabolitic profiling of amino acids in paraquat-induced acute kidney injury
This study examines the changes in serum amino acids (AAs) metabolite profiles as surrogate markers of renal cell metabolism and function after paraquat poisoning.MethodsTo identify the metabolic profiling of free serum AAs and its metabolites, serum from 40 paraquat-poisoned patients with or without AKI is collected. LC-MS/GC-MS is performed to analyze AA molecules. A Cox proportional hazard model was used to assess for incidence of AKI. Receiver operating characteristic (ROC) curve is applied to evaluate AKI occurrence and prognosis.ResultsA total of 102 serum AAs and its metabolites were identified. Compared with non-AK...
Source: Clinical and Experimental Nephrology - March 11, 2019 Category: Urology & Nephrology Source Type: research

Novel tubular –glomerular interplay in diabetic kidney disease mediated by sirtuin 1, nicotinamide mononucleotide, and nicotinamide adenine dinucleotide Oshima Award Address 2017
AbstractTubules interact with glomeruli, which are composed of podocytes, parietal epithelial cells, mesangial cells, and glomerular endothelial cells. Glomerular –tubular balance and tubuloglomerular feedback are the two components of the tubular–glomerular interplay, which has been demonstrated to play roles in physiological renal function and in diabetic kidney disease (DKD), in which proteins leaking from glomeruli arrive at tubular regions, leading t o further tubular injury caused by the accumulation of proteinuria-inducing reactive oxygens species and various cytokines. In the current review, we present ...
Source: Clinical and Experimental Nephrology - March 11, 2019 Category: Urology & Nephrology Source Type: research

Characteristics of membranoproliferative glomerulonephritis based on a new classification at a single center
ConclusionThese results suggested no significant differences in complement activation of the solid phase in local glomeruli and therefore no equivalence in renal prognosis. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - March 11, 2019 Category: Urology & Nephrology Source Type: research

Human MiR-4660 regulates the expression of alanine –glyoxylate aminotransferase and may be a biomarker for idiopathic oxalosis
AbstractBackgroundDysfunction of oxalate synthesis can cause calcium oxalate stone disease and inherited primary hyperoxaluria (PH) disorders. PH type I (PH1) is one of the most severe hyperoxaluria disorders, which results in urolithiasis, nephrocalcinosis, and end-stage renal disease. Here, we sought to determine the role of microRNAs in regulatingAGXT to contribute to the pathogenesis of mutation-negative idiopathic oxalosis.MethodsWe conducted bioinformatics to search for microRNAs binding toAGXT, and examined the expression of the highest hit (miR-4660) in serum samples of patients with oxalosis, liver tissue samples,...
Source: Clinical and Experimental Nephrology - March 9, 2019 Category: Urology & Nephrology Source Type: research

Assessment of treatment efficacy using surface-enhanced Raman spectroscopy analysis of urine in rats with kidney transplantation or kidney disease
The objective of this study was to develop a model to estimate the kidney damage and function by surface-enhanced Raman spectroscopy (SERS).MethodsUrine samples were collected from two previous studies: renal allograft recipient Lewis rats receiving anti-TGF- β antibody or control antibody treatment and obese diabetic ZSF1 rats with kidney disease fed with whole grape powder-containing chow or control chow. Silver nanoparticle-based SERS spectra of urine were measured. SERS spectra were analyzed using principal component analysis (PCA) combined with lin ear discriminant analysis (LDA) and partial least squires (PLS) a...
Source: Clinical and Experimental Nephrology - March 4, 2019 Category: Urology & Nephrology Source Type: research

Characteristics of coronary artery disease in chronic kidney disease
AbstractPatients with chronic kidney disease (CKD) commonly experience cardiovascular disease (CVD), and a major cause of death in these patients is CVD. Therefore, the prevention of CVD progression is very crucial in patients with CKD. Recently, this relationship between CKD and CVD has increasingly been examined, and a concept termed “cardiorenal syndrome” has been advocated. Coronary artery disease (CAD) and myocardial injury are crucial factors that contribute to the occurrence of CVD. The initial step CAD is endothelial dysfunction that can be detected as a decrease in the coronary flow reserve (CFR). The ...
Source: Clinical and Experimental Nephrology - March 4, 2019 Category: Urology & Nephrology Source Type: research

High levels of stromal cell-derived factor-1 α predict short-term progression of renal dysfunction in patients with coronary artery disease
This study examined whether high levels of SDF-1α are as sociated with future declines in renal function in patients with coronary artery disease (CAD).MethodsPlasma levels of SDF-1 α in the peripheral blood were measured by enzyme-linked immunosorbent assay in 344 patients with CAD. All patients were followed for 24 months or until the occurrence of renal dysfunction, defined as ≥ 25% decrease in estimated glomerular filtration rate (eGFR) from baseline.ResultsDuring the follow-up period, 36 patients developed renal dysfunction. Multivariate logistic regression analysis showed that high plasma levels...
Source: Clinical and Experimental Nephrology - March 4, 2019 Category: Urology & Nephrology Source Type: research

Reverse translational research of autophagy and metabolism in kidney disease: Oshima Award Address 2018
AbstractThe management of chronic kidney disease (CKD) has been a great challenge. Focusing on the difficulty to predict the prognosis of CKD, we initially conducted a series of observational studies, and evaluated the prognostic impacts of cardiac, diabetic, kidney, as well as senescent profiles, on CKD. Aiming to protect tubular inflammatory lesions, we studied the roles of autophagy, a process of auto-degradation for cellular homeostasis, in kidney diseases. After having determined its protective role, the proceedings of our autophagy studies are now revealing the mechanisms whereby autophagy protects kidney; autophagy ...
Source: Clinical and Experimental Nephrology - March 2, 2019 Category: Urology & Nephrology Source Type: research

Correction to: Clinical epidemiology of infectious disease among patients with chronic kidney disease
The article “Clinical epidemiology of infectious disease among patients with chronic kidney disease”, written by Junichi Ishigami and Kunihiro Matsushita, was originally published electronically on the publisher’s internet portal (currently SpringerLink) on 3rd September 2018 without open access. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - March 2, 2019 Category: Urology & Nephrology Source Type: research

Regional variance in patterns of prescriptions for chronic kidney disease in Japan
ConclusionSubstantial regional variation in CKD-related drug prescriptions exists even within a uniform health care system. The number of certified nephrologists was associated with the prescribed amount for PBs and ESAs. Further studies are needed to clarify whether geographic distribution of certified nephrologist may affect clinical practice pattern. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - March 1, 2019 Category: Urology & Nephrology Source Type: research

Tubular dysfunction in extremely low birth weight survivors
ConclusionTubular dysfunction is common in ELBW survivors. Some abnormalities resolved with age while some remained persistent or even increased. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - February 27, 2019 Category: Urology & Nephrology Source Type: research

Protection of the kidney with sodium –glucose cotransporter 2 inhibitors: potential mechanisms raised by the large-scaled randomized control trials
AbstractThis communication provides a current overview on the renal protective effects of sodium –glucose cotransporter 2 (SGLT2) inhibitors in diabetics. Following the epoch-making publications, the CANVAS Program and the EMPA-REG OUTCOME trial, numerous literature has discussed the mechanisms by which SGLT2 inhibition exerts its cardio-renal protective effects. Some of them reached agreemen t, while others did not. This review focuses on the hemodynamic aspect and the remaining potential factors relevant to the renal protection which have not been so much taken up by other review papers. Questions unanswered includ...
Source: Clinical and Experimental Nephrology - February 27, 2019 Category: Urology & Nephrology Source Type: research

Clinical outcome of incident peritoneal dialysis patients with diabetic kidney disease
ConclusionsTechnical and patient survivals of diabetic PD patients were not inferior to those of non-diabetic PD patients. These results suggest that no hesitation is warranted in initiating PD for diabetic patients with end-stage renal disease. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - February 27, 2019 Category: Urology & Nephrology Source Type: research

Author ’s reply to the letter to the editor regarding “Use of early postoperative serum creatinine changes to predict acute kidney injury after cardiothoracic surgery”
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - February 27, 2019 Category: Urology & Nephrology Source Type: research

Use of early postoperative serum creatinine changes to predict acute kidney injury after cardiothoracic surgery
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - February 27, 2019 Category: Urology & Nephrology Source Type: research

The beneficial effects of renin –angiotensin system inhibitors (RASI) on IgA nephropathy with tubulointerstitial lesions categorized by Oxford classification
ConclusionRASI has shown a significant beneficial effect on histologically advanced IgAN patients with T lesions. These results are compatible with the previous studies that reported the beneficial effects of RASI on clinically advanced IgAN patients. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - February 22, 2019 Category: Urology & Nephrology Source Type: research

Effects of renal denervation on blood pressure in hypertensive patients with end-stage renal disease: a single centre experience
ConclusionOur single-centre pilot study not only supports current data on renal safety of RDN even in small arteries of patients with ESRD, but also enhances the knowledge towards an effective ABP reduction in this type of hypertensive patients. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - February 19, 2019 Category: Urology & Nephrology Source Type: research

Regional prescription surveillance of phosphate binders in the western Saitama area: the substantial role of ferric citrate hydrate in improving serum phosphorus levels and erythropoiesis
AbstractBackgroundIn April 2015, five types of phosphate binders (PBs) were available by prescription in Japan, namely calcium carbonate, sevelamer hydrochloride, lanthanum carbonate, bixalomer, and ferric citrate hydrate (FeC). FeC reduces serum phosphorus levels and increases the body ’s iron stores. However, it is unclear whether FeC lowers serum phosphorus relative to other agents in a regional practical setting.MethodsWe performed a retrospective observational cohort study of regional hemodialysis surveillance in the western Saitama area of Japan, which included 1374 hemodialysis patients enrolled from 32 satell...
Source: Clinical and Experimental Nephrology - February 19, 2019 Category: Urology & Nephrology Source Type: research

Ultrasound microscopy through a fine fiber for renal tissues
(Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - February 19, 2019 Category: Urology & Nephrology Source Type: research

Predictors of withdrawal from renal replacement therapy among patients with acute kidney injury requiring renal replacement therapy
ConclusionAmong patients with AKI requiring RRT, CKD, ventilator use, hypoalbuminemia, and high MAP were associated with RRT withdrawal. Furthermore, keeping a higher MAP at RRT initiation  can potentially lead to dependence on RRT. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - February 16, 2019 Category: Urology & Nephrology Source Type: research