Path tracking control of a steerable catheter in transcatheter cardiology interventions
ConclusionThe preliminary in vitro studies presented in this paper showed promising accuracy in navigating the catheter within the vessel. The proposed approach enables autonomous control of a steerable catheter for transcatheter cardiology interventions without the request of calibrating the intuitive parameters or acquiring a training dataset. (Source: International Journal of Computer Assisted Radiology and Surgery)
Source: International Journal of Computer Assisted Radiology and Surgery - March 28, 2024 Category: Intensive Care Source Type: research

Evaluation of aconitine cardiotoxicity with a heart-on-a-particle prepared by a microfluidic device
Chem. Commun., 2024, Accepted Manuscript DOI: 10.1039/D4CC00396A, CommunicationTong Xu, Zengnan Wu, hongren yao, Yingrui Zhang, Shiyu Chen, Yuxuan Li, Xianli Meng, Yi Zhang, Jin-Ming Lin A heart-on-a-particle model based on multicompartmental microgel is proposed to simulate the heart microenvironment and study the cardiotoxicity of drugs. The relevant microgel was fabricated by a biocompatible microfluidic-based approach,... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Chem. Commun. latest articles)
Source: RSC - Chem. Commun. latest articles - March 28, 2024 Category: Chemistry Authors: Tong Xu Source Type: research

HINT2 protects against pressure overload-induced cardiac remodelling through mitochondrial pathways
J Cell Mol Med. 2024 Apr;28(8):e18276. doi: 10.1111/jcmm.18276.ABSTRACTHistidine triad nucleotide-binding protein 2 (HINT2) is an enzyme found in mitochondria that functions as a nucleotide hydrolase and transferase. Prior studies have demonstrated that HINT2 plays a crucial role in ischemic heart disease, but its importance in cardiac remodelling remains unknown. Therefore, the current study intends to determine the role of HINT2 in cardiac remodelling. HINT2 expression levels were found to be lower in failing hearts and hypertrophy cardiomyocytes. The mice that overexpressed HINT2 exhibited reduced myocyte hypertrophy an...
Source: J Cell Mol Med - March 28, 2024 Category: Molecular Biology Authors: Nan Zhang Zi-Ying Zhou Yan-Yan Meng Hai-Han Liao Shan-Qi Mou Zheng Lin Han Yan Si Chen Qi-Zhu Tang Source Type: research

Azvudine for the Treatment of COVID-19 in Pre-Existing Cardiovascular Diseases: A Single-Center, Real-World Experience
This study indicated that Azvudine therapy is associated with better outcomes in COVID-19 patients with pre-existing cardiovascular diseases.PMID:38544344 | DOI:10.1002/advs.202306050 (Source: Adv Data)
Source: Adv Data - March 28, 2024 Category: Epidemiology Authors: Liu Wu Zhong-Han He Ling Huang Xin Guo Xu-Yong Li Hong-Da Zhang Man-Hua Chen Source Type: research

Novel copy number variations and phenotypes of infantile epileptic spasms syndrome
In conclusion, CNVs is a prominent etiology of IESS. 1p36 deletion and 15q duplication occurred most frequently. CNV detection should be performed in patients with IESS of unknown causes, especially in children with craniofacial anomalies and microcephaly.PMID:38544467 | DOI:10.1111/cge.14520 (Source: Clinical Genetics)
Source: Clinical Genetics - March 28, 2024 Category: Genetics & Stem Cells Authors: Miaomiao Cheng Ling Bai Ying Yang Wenwei Liu Xueyang Niu Yi Chen Quanzhen Tan Xiaoling Yang Qixi Wu Han-Qing Zhao Yuehua Zhang Source Type: research

Clinical exome sequencing uncovers genetic disorders in neonates with suspected hypoxic-ischemic encephalopathy: A retrospective analysis
Clin Genet. 2024 Mar 28. doi: 10.1111/cge.14522. Online ahead of print.ABSTRACTHypoxic-ischemic encephalopathy (HIE) occurs in up to 7 out of 1000 births and accounts for almost a quarter of neonatal deaths worldwide. Despite the name, many newborns with HIE have little evidence of perinatal hypoxia. We hypothesized that some infants with HIE have genetic disorders that resemble encephalopathy. We reviewed genetic results for newborns with HIE undergoing exome or genome sequencing at a clinical laboratory (2014-2022). Neonates were included if they had a diagnosis of HIE and were delivered ≥35 weeks. Neonates were exclud...
Source: Clinical Genetics - March 28, 2024 Category: Genetics & Stem Cells Authors: Christian M Parobek Roni Zemet Matthew A Shanahan Brian A Burnett Elizabeth Mizerik Jill A Rosenfeld Liesbeth Vossaert Steven L Clark Jill V Hunter Seema R Lalani Source Type: research

Advances and Innovations in Cardiovascular Imaging
RADIOLOGIC CLINICS OF NORTH AMERICA (Source: Radiologic Clinics of North America)
Source: Radiologic Clinics of North America - March 28, 2024 Category: Radiology Authors: Prashant Nagpal, Sandeep Hedgire Source Type: research

More than just a clinical syndrome: Biomarkers and echocardiography should be rapidly advised for anyone with suspected heart failure!
(Source: European Journal of Heart Failure)
Source: European Journal of Heart Failure - March 28, 2024 Category: Cardiology Authors: Erwan Donal, Louis Gegout, K. Charlotte Lee Tags: Invited Editorial Source Type: research

Nonpharmacologic rate control of postoperative atrial fibrillation in the canine sterile pericarditis model
ConclusionDuring sustained POAF, nonpharmacologic rate control by AVN fat pad stimulation effectively and safely controlled rapid ventricular rates throughout the postoperative period. (Source: Journal of Cardiovascular Electrophysiology)
Source: Journal of Cardiovascular Electrophysiology - March 28, 2024 Category: Cardiology Authors: Seungyup Lee, Don Wallick, Celeen Khrestian, Dragan Juzbasich, Daniel Laurita, Gregory Rushing, Jayakumar Sahadevan Tags: ORIGINAL ARTICLE Source Type: research

A 3D heteropolyoxoniobate framework based on heart-shaped {Te2Nb19O60} clusters with proton conduction property
Dalton Trans., 2024, Accepted Manuscript DOI: 10.1039/D4DT00386A, PaperPing-Xin Wu, Yue Han, Yujin Lin, Yan-Qiong Sun, Shou-Tian Zheng A 3D tellurium-substituted heteropolyoxoniobate framework H5K3Na[Cu(en)2]2[Cu(en)0.75(H2O)2.5]{[(Te2Nb19O58)( μ3-OH)2]}·23H2O (1, en= ethylenediamine) with 6-connected pcu topology is built from heart-shaped {Te2Nb19O60} clusters and copper complexes. The {Te2Nb19O60} cluster represents the new tellurniobate structure... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Dalton Trans. latest articles)
Source: RSC - Dalton Trans. latest articles - March 28, 2024 Category: Chemistry Authors: Ping-Xin Wu Source Type: research

Adeno ‐associated virus‐based approach for genetic modification of cardiac fibroblasts in adult rat hearts
AbstractCardiac fibroblasts (CFs) are an attractive target for reducing pathological cardiac remodeling, and understanding the underlying mechanisms of these processes is the key to develop successful therapies for treating the pressure-overloaded heart. CF-specific knockout (KO) mouse lines with a Cre recombinase under the control of human TCF21 (hTCF21) promoter and/or an adeno-associated virus serotype 9 (AAV9)-hTCF21 system provide a powerful tool for understanding CF biology in  vivo. Although a variety of rat disease models are vital for the research of cardiac fibrosis similar to mouse models, there are few rat mod...
Source: Physiological Reports - March 28, 2024 Category: Physiology Authors: Bridget Nieto, Michael W. Cypress, Bong Sook Jhun, Jin O ‐Uchi Tags: SHORT REPORT Source Type: research

Sensors, Vol. 24, Pages 2171: Neurophysiological and Autonomic Correlates of Metacognitive Control of and Resistance to Distractors in Ecological Setting: A Pilot Study
ioletti In organisational contexts, professionals are required to decide dynamically and prioritise unexpected external inputs deriving from multiple sources. In the present study, we applied a multimethodological neuroscientific approach to investigate the ability to resist and control ecological distractors during decision-making and to explore whether a specific behavioural, neurophysiological (i.e., delta, theta, alpha and beta EEG band), or autonomic (i.e., heart rate—HR, and skin conductance response—SCR) pattern is correlated with specific personality profiles, collected with the 10-i...
Source: Sensors - March 28, 2024 Category: Biotechnology Authors: Michela Balconi Carlotta Acconito Roberta A. Allegretta Laura Angioletti Tags: Article Source Type: research

Resting heart rate associations with violence exposure and posttraumatic stress symptoms: sex differences in children
ConclusionIn our sample of primarily Black urban children, we found that violence exposure was associated with slower, more adult-like HR, that girls showed greater PTSS associated with slower HR while boys did not, and that girls with lower than normative HR showed significantly higher PTSS compared to girls with normative HR. Our sample ’s demonstration of psychological consequences in addition to the physiological implications could provide new information about a psychobiological sequelae of violence exposure. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - March 28, 2024 Category: Biology Source Type: research

Standardized production of hPSC-derived cardiomyocyte aggregates in stirred spinner flasks
We present a protocol for achieving efficient generation of hPSC-CM aggregates in suspension culture, emphasizing process simplicity, robustness and GMP compliance. The strategy promotes clinical translation and other applications that require large numbers of CMs. (Source: Nature Protocols)
Source: Nature Protocols - March 28, 2024 Category: Biomedical Science Authors: Nils Kriedemann Wiebke Triebert Jana Teske Mira Mertens Annika Franke Kevin Ullmann Felix Manstein Lika Drakhlis Alexandra Haase Caroline Halloin Ulrich Martin Robert Zweigerdt Source Type: research

Curvilinear association between waist-to-height ratio and cardiorespiratory fitness: a cross-sectional study based on nationwide data from Chinese children and adolescents
ConclusionsThere is a curvilinear association between WHtR and CRF in Chinese children and adolescents. Both lower and higher WHtR led to a decrease in VO2max in children and adolescents. (Source: BMC Sports Science, Medicine and Rehabilitation)
Source: BMC Sports Science, Medicine and Rehabilitation - March 28, 2024 Category: Sports Medicine Source Type: research